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1
Willsky, Lydia. "The (Un)Plain Bible." Nova Religio 17, no. 4 (February 2013): 13–36. http://dx.doi.org/10.1525/nr.2014.17.4.13.
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This article explores the phenomenon of nineteenth-century new religious movements as a reaction to the “plain Bible” religious culture of that era. The plain Bible thesis maintained that the Bible was clear in its meaning, persuasive in its message, and authoritative in all matters of truth. Through the examples of Joseph Smith, Mary Baker Eddy and Henry David Thoreau, this article illustrates how three religious innovators reacted against the plain Bible thesis by creating their own versions of scripture which, in turn, aided in creating or strengthening alternative forms of Christianity. With his Mormon scriptural canon, including The Book of Mormon, Doctrine and Covenants, and Pearl of Great Price, Smith combated the notion that the Bible was clear in meaning; with her sacred text Science and Health Eddy challenged the persuasiveness of the plain Bible; and with his manuscript Wild Fruits, Thoreau undermined the plain Bible’s singular authority. This article shows that many new religious movements were not outliers in nineteenth-century Christian culture but were in fact products of that culture, albeit reactionary ones.
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Forsberg Jr., Clyde. "Esotericism and the “Coded Word” in Mormonism." International Journal for the Study of New Religions 2, no. 1 (August 14, 2011): 29–54. http://dx.doi.org/10.1558/ijsnr.v2i1.29.
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In the history of American popular religion, the Latter-day Saints, or Mormons, have undergone a series of paradigmatic shifts in order to join the Christian mainstream, abandoning such controversial core doctrines and institutions as polygamy and the political kingdom of God. Mormon historians have played an important role in this metamorphosis, employing a version (if not perversion) of the Church-Sect Dichotomy to change the past in order to control the future, arguing, in effect, that founder Joseph Smith Jr’s erstwhile magical beliefs and practices gave way to a more “mature” and bible-based self-understanding which is then said to best describe the religion that he founded in 1830. However, an “esoteric approach” as Faivre and Hanegraaff understand the term has much to offer the study of Mormonism as an old, new religion and the basis for a more even methodological playing field and new interpretation of Mormonism as equally magical (Masonic) and biblical (Evangelical) despite appearances. This article will focus on early Mormonism’s fascination with and employment of ciphers, or “the coded word,” essential to such foundation texts as the Book of Mormon and “Book of Abraham,” as well as the somewhat contradictory, albeit colonial understanding of African character and destiny in these two hermetic works of divine inspiration and social commentary in the Latter-day Saint canonical tradition.
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ZARANDONA, Juan M. "Las distintas ediciones de El libro de Mormón en español o la posibilidad de la retraducción censurada en la búsqueda de la calidad, la precisión y el equilibrio." Hikma 10 (October 1, 2011): 195. http://dx.doi.org/10.21071/hikma.v10i.5260.
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The Book of Mormon (1930) no es solo un libro sagrado que asegura ser una traducción, sino que además es uno de los textos que más veces ha sido traducido y retraducido. El español constituye un muy buen ejemplo entre estas muchas lenguas a las que ha sido traducido. La primera versión española data del año 1875 y desde entonces se han publicado una serie constante de revisiones y retraducciones realizadas por diferentes traductores profesionales y no profesionales en 1886, 1929, 1952, 1988 y 1992. Todos ellos fueron proyectos de traducción promovidos y supervisados por la misma Iglesia Mormona. El presente artículo, en consecuencia, comparará todas estas versiones con el fin de valorar su calidad y las diferencias entre las mismas siguiendo un enfoque empírico. Además, se tendrán en cuenta diversas propuestas consolidadas de traducción bíblica y de textos sagrados, y la posibilidad de argumentar la necesidad de un tipo de censura necesario y responsable, sobre todo cuando se trata de escrituras sagradas, que produzca un proceso constante de retraducción que se encamine hacia una calidad, la precisión y el equilibrio cada vez mayores del texto traducido.
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Miller, Taylor-Grey, and Derek Haderlie. "Sider’s Puzzle and the Mormon Afterlife." Journal of Analytic Theology 8 (September 21, 2020): 131–51. http://dx.doi.org/10.12978/jat.2020-8.120817070004.
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There is a puzzle about divine justice stemming from the fact that God seems required to judge on the basis of criteria that are vague. Justice is proportional, however, it seems God violates proportionality by sending those on the borderline of heaven to an eternity in hell. This is Ted Sider’s problem of Hell and Vagueness. On the face of things, this poses a challenge only to a narrow class of classical Christians, those that hold a retributive theory of divine punishment. We show that this puzzle can be extended to the picture of divine judgement and the afterlife found in Mormon theology. This is significant because at first glance, the Mormon picture of the afterlife looks like it fails to co-operate with Sider’s puzzle. In Mormon theology, there are not two afterlife states, but three: a low, a middle, and a high kingdom. There is no afterlife state quite like Hell, and the states that function similarly to Hell aren’t places of eternal suffering. We argue that appearances are misleading. While it may be true that no place in the Mormon afterlife is bad in the sense that its inhabitants suffer eternal bodily harm, it is true that many of the places in the Mormon afterlife are bad in the sense that their inhabitants lack access to significant goods. This allows Sider’s puzzle to re-engage as a puzzle about distributive Justice. After setting out this alternative version of the puzzle, we argue that Mormon theology has sufficient resources to reject proportionality as a constraint on divine judgment by adopting a nuanced version of universalism called escapism.
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Braun, T., R. J. Schulz, M. Hoffmann, J. Reinke, L. Tofaute, C. Urner, H. Krämer, T. Bock, N. de Morton, and C. Grüneberg. "Deutsche Version des De Morton Mobility Index." Zeitschrift für Gerontologie und Geriatrie 48, no. 2 (November 13, 2014): 154–63. http://dx.doi.org/10.1007/s00391-014-0648-3.
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Liddiard Cárdenas, Stefany, Francisco Alberto Pérez Piñón, and Guillermo Hernández Orozco. "diáspora de los mormones fundamentalistas: Colonia LeBaron, Chihuahua." RECIE. Revista Electrónica Científica de Investigación Educativa 3, no. 2 (January 2, 2017): 839–45. http://dx.doi.org/10.33010/recie.v3i2.385.
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En este texto se explica el recorrido del grupo religioso mormón conocido como LeBaron desde su origen, su éxodo, el arribo al Estado de Chihuahua y cómo es que actualmente se encuentra constituido. Con el razonamiento que cada acontecimiento es resultado y causa de otro, se intenta explicar cómo se desarrolló el transitar de este grupo por diversos países, lo que permite observar las relaciones que se han dado entre sí y en las distintas geografías. El realizar una recuperación de diferentes versiones de historias relatadas por personajes de la misma comunidad brinda una mayor diversidad de puntos de vista, lo que permite lograr una explicación más puntual de los acontecimientos que han repercutido en esta comunidad en particular. Debido a que se tiene como propósito reconstruir, porque la existencia mormona a lo largo de su historia ya está construida, es la reconstrucción histórica, un reacomodo y análisis de los diversos factores que prioritariamente den cuenta de su educación, atendiendo a principios emanados de su recorrido existencial pero centrado en su vida en Chihuahua, a sabiendas de que la interacción con el contexto que le rodea le proporcionan el sentido específico a esta comunidad, en cuanto sus características básicas relativas a creencias, familia, función de la escuela, valor de la economía, la solidaridad, la familia monógama o ampliada, pero que a su vez tiene sus condiciones concretas fraguadas poco a poco en el entorno cultural de los municipios de Nuevo Casas Grandes y Galeana, sobre todo.
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Rokhlin, D. B. "An Extended Version of the Dalang--Morton--Willinger Theorem under Portfolio Constraints." Theory of Probability & Its Applications 49, no. 3 (January 2005): 429–43. http://dx.doi.org/10.1137/s0040585x97981184.
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Tereshchuk, A. A. "Comparative Analysis of Two Versions of A Chapter from the History of Charles V by Baron de los Valles." Bulletin of Kemerovo State University 24, no. 5 (November 7, 2022): 662–68. http://dx.doi.org/10.21603/2078-8975-2022-24-5-662-668.
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This article features two versions of A Chapter from the History of Charles V written by Louis Xavier Auguet de Saint- Sylvain, Baron de los Valles. The original French version was published in 1835, while the Spanish translation appeared 1837. The text describes the background and the start of the First Carlist War in Spain in 1833–1835. The author was a confidant of Don Carlos, and so his book reflected the Carlist perspective. The author believes that the Spanish translation included certain semantic modifications and additions made due to fit the changing political situation. These almost imperceptible modifications were able to change the perception of some military and political figures of the era, e.g., former Minister F. T. Calomarde, Carlist general V. Gonzalez Moreno, Christino general and future Regent B. Espartero, etc. The research objective was to show how Baron de los Valles interpreted the events related to the capture of Villafranca by the Carlists in 1834. This historical episode, later popularized by numerous memoirs and fiction, appeared only in the Spanish version of the book. The account made by the Baron de los Valles differed from the versions of other memoirists, as well as from the official press reports. A Chapter from the History of Charles V by Baron de los Valles has a low value as a historical source, but presents a considerable interest as an example of Carlist propaganda during the war of 1833–1840.
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Ivanov, A. G., and I. N. Pupysheva. "When Heidegger is a producer: being ecological according to version of Timothy Morton." Omsk Scientific Bulletin. Series Society. History. Modernity 4, no. 3 (2019): 129–35. http://dx.doi.org/10.25206/2542-0488-2019-4-3-129-135.
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Davis, Stephen T., and Eric T. Yang. "Social Trinitarianism Unscathed." Journal of Analytic Theology 5 (June 15, 2017): 220–29. http://dx.doi.org/10.12978/jat.v5i1.169.
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Social Trinitarianism (ST) is a family of views that bear some resemblance to each other in a way that distinguishes them from other Trinitarian accounts. In this paper, we address recent objections by Carl Mosser against ST, objections which have not received much attention by defenders of ST. Mosser claims that proponents of ST offer a narrative that is historically inaccurate, employs concepts of personhood and perichoresis that are incompatible, upholds dubious hermeneutical assumptions, and is unable to preclude Mormon theology within its fold. We argue that all four criticisms fail, especially for a specific version of ST: Perichoretic Monotheism.
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SHELLEY, BRAXTON. "‘Play the Rain Down’: Prince, Paul Morton, and the Idea of Black Ecstasy." Twentieth-Century Music 19, no. 1 (February 2022): 93–116. http://dx.doi.org/10.1017/s1478572221000244.
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AbstractThis article grapples with ‘Let It Rain’, the title track of Bishop Paul S. Morton and the Full Gospel Baptist Church Fellowship's 2003 release, which revises Michael Farren's contemporary Christian ballad by braiding it together with Prince's ‘Purple Rain’ and the formal logic of Black gospel tradition. As the Full Gospel version of this song commingles these seemingly discordant components, Morton, choir, and band turn a sung prayer into an assertion of interworldly presence. Building on its received musical materials, this gospel power ballad performs the Black gospel tradition's characteristic inflection – an arresting turn from one level of musicking to a heightened, ecstatic frame. In so doing, this song brings rain near, illuminating the links between performances of musical ecstasy and musical Blackness.
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Gutierrez-Moreno, A., H. Moreno, and G. Cortes. "Diagnostic Diagrams for Planetary Nebulae and Symbiotic Stars." Symposium - International Astronomical Union 155 (1993): 403. http://dx.doi.org/10.1017/s007418090017192x.
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One of us (Gutiérrez-Moreno 1988) presented some time ago a preliminary version of two diagrams for separating planetary nebulae (PN) from symbiotic stars (SS); tnese diagrams are based on the strength of [O III] lines λλ4363, 5007. Now a new version is presented, which includes more objects and uses measured total intensities corrected by reddening.
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HEATH, WILLIAM. "Thomas Morton: From Merry Old England to New England." Journal of American Studies 41, no. 1 (April 2006): 135–68. http://dx.doi.org/10.1017/s0021875806002787.
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Nathaniel Hawthorne claims, in his brief preface to “The May-pole of Merry Mount,” that “the facts, recorded on the grave pages of our New England annalists, have wrought themselves, almost spontaneously,” into a “philosophical romance” and “a sort of allegory.” He later refers to these “true” and “authentic passages from history” as “a poet's tale.” Yet to anyone familiar with the sources available to Hawthorne,1 nothing is more striking than how much authentic history he has left out – most notably Thomas Morton himself, whose version of what transpired at his fur-trading post on Massachusetts Bay (New English Canaan) is indeed a tale told by a poet, albeit a minor one. What do we know about the man who put up the maypole that so outraged his pious neighbors? Who was Thomas Morton and why were the Puritans so offended by him? If his maypole symbolized the festive culture of Merry Old England, Morton epitomized its spirit. No wonder he was a persona non grata among the Puritans of New England, although Falstaff would have welcomed him to the Boar's Head Tavern. Like many a man of the Elizabethan Renaissance, he was enamored of classical learning and the New World; three times he abandoned London's Bankside to seek his fortune in Massachusetts Bay, at the risk of his life.
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Zacarias Maldaner da Silva, Vinicius, Amanda Sanches Lima, Hilana Nadiele, Ruy Pires-Neto, Linda Denehy, and Selina M. Parry. "Brazilian Versions of the Physical Function ICU Test-scored and de Morton Mobility Index: translation, cross-cultural adaptation, and clinimetric properties." Jornal Brasileiro de Pneumologia 46, no. 4 (2020): e20180366-e20180366. http://dx.doi.org/10.36416/1806-3756/e20180366.
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LANGER, ADRIAN. "LOGARITHMIC ORBIFOLD EULER NUMBERS OF SURFACES WITH APPLICATIONS." Proceedings of the London Mathematical Society 86, no. 2 (March 2003): 358–96. http://dx.doi.org/10.1112/s0024611502013874.
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We introduce orbifold Euler numbers for normal surfaces with boundary $\mathbb{Q}$-divisors. These numbers behave multiplicatively under finite maps and in the log canonical case we prove that they satisfy the Bogomolov–Miyaoka–Yau type inequality. Existence of such a generalization was earlier conjectured by G. Megyesi [Proc. London Math. Soc. (3) 78 (1999) 241–282]. Most of the paper is devoted to properties of local orbifold Euler numbers and to their computation.As a first application we show that our results imply a generalized version of R. Holzapfel's ‘proportionality theorem’ [Ball and surface arithmetics, Aspects of Mathematics E29 (Vieweg, Braunschweig, 1998)]. Then we show a simple proof of a necessary condition for the logarithmic comparison theorem which recovers an earlier result by F. Calderón-Moreno, F. Castro-Jiménez, D. Mond and L. Narváez-Macarro [Comment. Math. Helv. 77 (2002) 24–38].Then we prove effective versions of Bogomolov's result on boundedness of rational curves in some surfaces of general type (conjectured by G. Tian [Springer Lecture Notes in Mathematics 1646 (1996) 143–185)]. Finally, we give some applications to singularities of plane curves; for example, we improve F. Hirzebruch's bound on the maximal number of cusps of a plane curve.2000 Mathematical Subject Classification: 14J17, 14J29, 14C17.
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Lanzarote-Fernández, María-Dolores, José-Francisco Lozano-Oyola, Montserrat Gómez-de-Terreros-Guardiola, Isabel Avilés-Carvajal, Rafael Martínez-Cervantes, and Jennette Moreno. "Spanish Version of the Family Health Behavior Scale: Adaptation and Validation." International Journal of Environmental Research and Public Health 16, no. 5 (March 6, 2019): 810. http://dx.doi.org/10.3390/ijerph16050810.
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Different studies around the world indicate that the percentages of overweight and obesity in childhood and adolescence are high. In this context, it would be useful to have a common, valid, and reliable instrument to assess health behaviors of families that allows comparisons of data from different countries. The objective is the adaptation of a Spanish version of the Family Health Behavior Scale (FHBS). The questionnaire originally developed by Moreno group was translated and adapted following the International Test Commission protocol. Its psychometric properties were evaluated through analysis of internal consistency, factor analysis and other evidences of validity. The Spanish version of the FHBS demonstrated adequate reliability coefficients, and its factor structure sufficiently replicated that obtained by the original measurement. The results suggested that the adapted version of the questionnaire was an adequate and valid measure for the evaluation of family health behaviors related to the prevention of overweight and obesity.
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Bhatia, Sugandh, and Jyoteesh Malhotra. "Morton Filter-Based Security Mechanism for Healthcare System in Cloud Computing." Healthcare 9, no. 11 (November 15, 2021): 1551. http://dx.doi.org/10.3390/healthcare9111551.
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Electronic health records contain the patient’s sensitive information. If these data are acquired by a malicious user, it will not only cause the pilferage of the patient’s personal data but also affect the diagnosis and treatment. One of the most challenging tasks in cloud-based healthcare systems is to provide security and privacy to electronic health records. Various probabilistic data structures and watermarking techniques were used in the cloud-based healthcare systems to secure patient’s data. Most of the existing studies focus on cuckoo and bloom filters, without considering their throughputs. In this research, a novel cloud security mechanism is introduced, which supersedes the shortcomings of existing approaches. The proposed solution enhances security with methods such as fragile watermark, least significant bit replacement watermarking, class reliability factor, and Morton filters included in the formation of the security mechanism. A Morton filter is an approximate set membership data structure (ASMDS) that proves many improvements to other data structures, such as cuckoo, bloom, semi-sorting cuckoo, and rank and select quotient filters. The Morton filter improves security; it supports insertions, deletions, and lookups operations and improves their respective throughputs by 0.9× to 15.5×, 1.3× to 1.6×, and 1.3× to 2.5×, when compared to cuckoo filters. We used Hadoop version 0.20.3, and the platform was Red Hat Enterprise Linux 6; we executed five experiments, and the average of the results has been taken. The results of the simulation work show that our proposed security mechanism provides an effective solution for secure data storage in cloud-based healthcare systems, with a load factor of 0.9. Furthermore, to aid cloud security in healthcare systems, we presented the motivation, objectives, related works, major research gaps, and materials and methods; we, thus, presented and implemented a cloud security mechanism, in the form of an algorithm and a set of results and conclusions.
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Pantuck, Allan, and Scott Brown. "Morton Smith as M. Madiotes: Stephen Carlson's Attribution of Secret Mark to a Bald Swindler." Journal for the Study of the Historical Jesus 6, no. 1 (2008): 106–25. http://dx.doi.org/10.1163/174551908x266051.
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AbstractIn 1960, Morton Smith announced that he had discovered in the Mar Saba monastery tower library a fragment of a previously unknown letter of Clement of Alexandria containing excerpts from a longer version of the Gospel of Mark that Smith called the 'Secret Gospel of Mark'. Controversial since its publication in 1973, this discovery has recently been criticized in print as both an academic hoax and a malicious forgery. This paper uses newly discovered manuscript photographs and archived documents to refute a claim found in Stephen C. Carlson's The Gospel Hoax, namely that Smith invented a pseudonymous twentieth-century individual named 'M. Madiotes' as an elaborate and deliberate clue that he himself had forged the letter of Clement.
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Gusti, Ilfira, and Sri Zulfia Novrita. "Perbedaan Hasil Pencelupan Bahan Sutera Menggunakan Ekstrak Kulit Pisang Kepok dengan Mordan Tawas dan Kapur Sirih." JURNAL PENDIDIKAN DAN KELUARGA 11, no. 02 (May 1, 2020): 161. http://dx.doi.org/10.24036/jpk/vol11-iss02/659.
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Abstract
This research is motivated as an effort to reduce the problem of environmental pollution by re-using natural dyes. The natural dyes used are the utilization of waste which is kepok banana peel. The purpose of this study is to describe the name of the color (hue), dark light (value), and evenness of color as well as differences in mordan alum and whiting to the results of dyeing silk material using kapok banana peel extract (MusaParadisiaca L). This type of research is experimental research. Data collection techniques using a questionnaire (questionnaire) from 18 panelists. The data analysis technique was carried out using the Friedman K-related sample test technique and using the SPSS (Statistical Product and Service Solution) version 16.0 application. Dipping silk material with Kepok Banana peel extract (MusaParadisiaca L) without mordan yielding a Wheat Light Brown color with Code # F6E7B0 and value category very bright and evenness of color in the very flat category. In dyeing with mordan alum produces Light Brown color with code # E7BE75 with light category and flatness value in the flat category, while in dyeing with mordan whiting the color name is Golden Sundanese with code # D7A04F with the value of the category light enough and flat for the category flatness. Friedman K-related sample test results obtained for light dark color (value) is 0.001 <0.05, then H0 is rejected, meaning that there are significant color differences. Whereas the color density of the data obtained was 0.154> 0.05, H0 was accepted, meaning that there was no significant difference in color evenness in the dyeing of silk material using Kepok banana peel extract (MusaParadisiaca L) with mordan alum and whiting.
Keywords: mordan alum and betel lime, kepok banana peel (Musa Paradisiaca L), silk material
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Saadah, Saadah, and Agusti Efi. "Pengaruh Perbedaan Mordan Terhadap Hasil Pencelupan Pada Bahan Katun Menggunakan Ekstrak Kulit Buah Kopi (Coffea)." Indonesian Journal of Education Research 1, no. 1 (January 9, 2020): 40–44. http://dx.doi.org/10.24036/edunesia.v1i1.7.
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Abstrak
Perkembangan warna tekstil dengan zat kimia banyak membawa dampak negatif terutama bagi lingkungan dan kesehatan kulit. Oleh sebab itu orang kembali menggunakan zat warna alam, maka dalam penelitian ini meneliti kulit buah kopi untuk zat warna alam.
Jenis penelitian ini merupakan penelitian eksperimen. Data yang digunakan adalah data primer yang bersumber dari 15 orang panelis, kemudian data yang terkumpul diolah dan dianalisis menggunakan Uji Friedman K-Related Sample dan persen dengan SPSS (Statistical Product and Service Solution) Versi 21.0. penulis melakukan eksperimen kulit buah kopi menjadi ekstrak warna dengan perbndingan 1:10 menggunakan mordan asam cuka, soda kue dan kapur sirih.
Pencelupan bahan katun dengan ekstrak kulit buah kopi (Coffea) menggunakan mordan asam cuka Off-White dengan kode warna #1DBCA dan kerataan warna yang rata, pencelupan ekstrak kulit buah kopi (Coffea) menggunakan mordan soda kue menghasilkan warna Wheat Lihgt Brown dengan kode warna #FDB4D4 dan kerataan warna yang cukup rata, pencelupan ekstrak kulit buah kopi (Coffea) menggunakan mordan kapur sirih menghasilkan warna Sepia Brown dengan kode warna #974706 dan dengan kerataan warna yang rata. pada kerataan warna menunjukkan hasil 0,528 > 0,5 yang artinya HO diterima. artinya tidak terdapat pengaruh yang signifikan akibat perbedaan mordan terhadap kerataan warna dalam pencelupan bahan katun.
Kata Kunci: pengaruh, perbedaan mordan, pencelupan, bahan katun, ekstrak kulit buah kopi
Abstract
The development of textile colors with chemicals has many negative impacts, especially on the environment and skin health. Therefore people re-use natural dyes. So in this study, the authors examined the skin of coffee fruit for natural dyes.
This type of research is experimental research. The data used are primary data sourced from 15 panelists, then the collected data is processed and analyzed using the Friedman K-Related Sample Test and percent with SPSS (Statistical Product and Service Solution) Version 21.0. The author conducted a coffee fruit skin experiment into a color extract with a ratio of 1:10 using mordan vinegar, baking soda, and whiting .
Immersion of cotton with coffee fruit skin extract (Coffea) using mordan acid vinegar Off-White with color code # 1DBCA and flat color uniformity, dyeing coffee fruit skin extract (Coffea) using mordan soda cake to produce Wheat Light Brown color with color code # FDB4D4 and fairly flat color evenness, immersion extract of coffee fruit skin (Coffea) using mordan whiting produces Sepia Brown color with color code # 974706 and with flat color evenness. on the flatness of color shows the results 0.528> 0.5, which means that HO is accepted. meaning that there is no significant effect due to differences in mordan on the evenness of color in dyeing cotton.
Keywords: influence, differences in mordan, dyeing, cotton, coffee skin extract
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Fatihaturahmi, Fatihaturahmi, and Sri Zulfia Novrita. "PENGARUH PERBEDAAN MORDAN TAWAS DAN KAPUR SIRIH TERHADAP HASIL PENCELUPAN EKSTRAK DAUN SAWO MENGGUNAKAN BAHAN SUTERA." Gorga : Jurnal Seni Rupa 8, no. 1 (July 2, 2019): 237. http://dx.doi.org/10.24114/gr.v8i1.13606.
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AbstrakPenggunaan ekstrak zat warna alam sebagai pewarnaan tekstil karena menghasilkan warna yang khas dan ramah lingkungan salah satunya adalah daun sawo. Tujuan penelitian ini adalah mendeskripsikan nama warna (Hue), gelap terang (Value) serta kerataan warna serta perbedaan mordan tawas dan kapur sirih terhadap hasil pencelupan ekstrak daun sawo menggunakan bahan sutera. Jenis penelitian ini merupakan eksperimen. Data yang digunakan adalah data primer yang bersumber dari 18 panelis, kemudian data yang terkumpul diolah dan dianalisis menggunakan uji Friedman K-related sample serta menggunakan aplikasi SPSS (Statistical Product and Service Solutions) versi 16.0. Pencelupan bahan sutera dengan ekstrak daun sawo masing-masing tanpa mordan menghasilkan warna Canary Yellow dengan kode #EAF59A serta Value sangat terang dan cukup terang dan kerataan warna yang rata, mordan tawas menghasilkan warna Canary Yellow dengan kode #FFFF53 serta Value terang dan memiliki kerataan warna yang rata, serta mordan kapur sirih menghasilkan warna Dark Golden Rod dengan kode #D3820B serta Value kurang terang dan kerataan warna yang dihasilkan rata. Hasil penelitian data gelap terang warna (Value) yaitu 0,000 < 0,05 yang artinya Ho ditolak. Artinya terdapat pengaruh perbedaan yang signifikan mordan tawas dan kapur sirih terhadap hasil pencelupan. Pada kerataan warna menunjukkan hasil 0,063 > 0,05 yang artinya Ho diterima. Artinya tidak terdapat pengaruh yang signifikan mordan tawas dan kapur sirih terhadap hasil pencelupan ekstrak daun sawo menggunakan bahan sutera. Kata Kunci: daun sawo, tawas, kapur sirih.AbstractThe use of extracts of natural dyes as textile coloring because it produces a distinctive and environmentally friendly color, one of which is brown leaves. The purpose of this study was to describe the name of color (Hue), darkness of light (Value) and evenness of color as well as differences in mordan alum and whiting to the results of dyeing sapodilla leaf extract using silk material. This type of research is an experiment. The data used are primary data sourced from 18 panelists, then the collected data is processed and analyzed using the Friedman K-related sample test and using the SPSS application (Statistical Product and Service Solutions) version 16.0. Dyeing of silk material with sapodilla leaf extract without mordan produced Canary Yellow color with code # EAF59A and Value very bright and quite bright and even color evenness, mordan alum produced Canary Yellow colors with code # FFFF53 and bright values and had evenness the flat, and the betel mordan produces the Dark Golden Rod color with code # D3820B and the Value is less bright and the flatness of the resulting color is even. The results of the study of dark light colors (Value) are 0,000 <0,05 which means that Ho is rejected. This means that there are significant effects of mordan alum and whiting on the results of dyeing. The color flatness shows the results of 0.063> 0.05, which means that Ho is accepted. This means that there is no significant effect of mordan alum and whiting on the results of dyeing sapodilla leaf extract using silk. Keywords: sapodilla leaves, alum, betel lime.
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Prima, Annisa, and Sri Zulfia Novrita. "PENGARUH PERBEDAAN KONSENTRASI TAWAS PADA PENCELUPAN BAHAN KATUN MENGGUNAKAN ZAT WARNA ALAM EKSTRAK BUAH SENDUDUK (MELASTOMA MALABATHRICUM L)." Gorga : Jurnal Seni Rupa 8, no. 1 (July 2, 2019): 260. http://dx.doi.org/10.24114/gr.v8i1.13630.
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AbstrakPenggunaan ekstrak zat warna alam sebagai pewarnaan tekstil karena menghasilkan warna yang khas dan ramah lingkungan salah satunya adalah buah senduduk (Melastoma Malabathricum L). Tujuan penelitian ini adalah mendeskripsikan nama warna (Hue), gelap terang (Value), kerataan warna serta pengaruh perbedaan konsentrasi mordan tawas terhadap kain katun pada hasil pencelupan menggunakan ekstrak buah senduduk (Melastoma Malabathricum L). Jenis penelitian ini merupakan eksperimen. Data yang digunakan adalah data primer yang bersumber dari 18 panelis, lalu diolah dan dianalisis menggunakan uji Friedman K-related sample serta menggunakan aplikasi SPSS (Statistical Product and Service Solutions) versi 18.0. Pencelupan bahan katun dengan ekstrak buah senduduk masing-masing tanpa mordan menghasilkan warna Dark Purple #5A2364 serta Value cukup terang dan kerataan warna yang rata, mordan tawas pada konsentrasi 10 gram menghasilkan warna Pompadour Purple #704664 serta Value kurang terang dan memiliki kerataan warna yang rata, mordan tawas pada konsentrasi 50 gram menghasilkan warna Pompadour Purple #7D415F serta Value cukup terang dan memiliki kerataan warna yang rata, serta mordan tawas pada konsentrasi 100 gram menghasilkan warna Cold Purple #9780B2 serta terang dan kerataan warna yang dihasilkan cukup rata. Hasil penelitian data gelap terang warna (Value) yaitu 0,000 < 0,05 yang artinya Ho ditolak. Artinya terdapat pengaruh perbedaan yang signifikan pada perbedaan mordan pada konsentrasi 10 gram, 50 gram dan 100 gram terhadap hasil pencelupan. Pada kerataan warna menunjukkan hasil 0,045 > 0,05 yang artinya Ho diterima. Artinya tidak terdapat pengaruh yang signifikan mordan tawas pada konsentrasi 10 gram, 50 gram dan 100 gram terhadap hasil pencelupan ekstrak buah senduduk menggunakan bahan katun.Kata Kunci: buah senduduk, tawas.AbstractThe use of extracts of natural dyes as textile coloring because they produce a distinctive and environmentally friendly color, one of which is senduduk (Melastoma Malabathricum L). The purpose of this study was to describe the name of color (Hue), light darkness (Value), color flatness and the effect of differences in the concentration of mordan alum on cotton cloth on the results of dyeing using senduduk fruit extract (Melastoma Malabathricum L). This type of research is an experiment. The data used are primary data sourced from 18 panelists, then the collected data is processed and analyzed using the Friedman K-related sample test and using the SPSS application (Statistical Product and Service Solutions) version 16.0. Dyeing of cotton material with senduduk fruit extract (Melastoma Malabathricum L) without a mordan each produces Dark Purple # 5A2364 and the value is quite bright and evenly colored, the mordan alum at 10 grams produces Pompadour Purple # 704664 and The value is less bright and has a flat evenness, mordan alum at a concentration of 50 grams produces Pompadour Purple # 7D415F and the value is quite bright and has a flat color evenness, and mordan alum at 100 grams produces Cold Purple # 9780B2 and the light and evenness of the resulting color is quite flat. The results of the study of dark light colors (Value) are 0,000 <0,05 which means that Ho is rejected. This means that there are significant differences in the effect of mordan on concentrations of 10 grams, 50 grams and 100 grams on the results of dyeing. The color flatness shows the results of 0.045> 0.05, which means that Ho is accepted. This means that there is no significant effect of mordan alum at concentrations of 10 grams, 50 grams and 100 grams on the results of dyeing the fruit extract of senduduk using cotton. Keywords: senduduk fruit, alum.
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Barro, Susan, Paul Gobster, Herbert Schroeder, and Stephen Bartram. "What Makes a Big Tree Special? Insights from the Chicagoland Treemendous Trees Program." Arboriculture & Urban Forestry 23, no. 6 (November 1, 1997): 239–49. http://dx.doi.org/10.48044/jauf.1997.037.
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In 1995, a local version of the American Forests big trees program (Treemendous Trees) was initiated in the Chicago area by Openlands Project and the Morton Arboretum. In addition to the numerical information about tree sizes required on the nomination form, many participants attached notes and sometimes lengthy letters that detailed various aspects of the nominated trees. A qualitative analysis of these written materials identified a number of recurrent themes that sometimes went far beyond the physical size dimensions to describe aesthetic and functional values, and symbolic and emotional meanings. This information may help urban foresters better understand the breadth and depth of values people have for urban trees—particularly large ones. Results also have implications for obtaining more and better information from big tree programs, and for using these programs as vehicles for developing collaborative partnerships between urban foresters and citizens in knowledge discovery and sharing.
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DOYLE, JOHN R., HOLLY KRIEGER, ANDREW OBUS, RACHEL PRIES, SIMON RUBINSTEIN-SALZEDO, and LLOYD WEST. "Reduction of dynatomic curves." Ergodic Theory and Dynamical Systems 39, no. 10 (January 25, 2018): 2717–68. http://dx.doi.org/10.1017/etds.2017.140.
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In this paper, we make partial progress on a function field version of the dynamical uniform boundedness conjecture for certain one-dimensional families ${\mathcal{F}}$ of polynomial maps, such as the family $f_{c}(x)=x^{m}+c$, where $m\geq 2$. We do this by making use of the dynatomic modular curves $Y_{1}(n)$ (respectively $Y_{0}(n)$) which parametrize maps $f$ in ${\mathcal{F}}$ together with a point (respectively orbit) of period $n$ for $f$. The key point in our strategy is to study the set of primes $p$ for which the reduction of $Y_{1}(n)$ modulo $p$ fails to be smooth or irreducible. Morton gave an algorithm to construct, for each $n$, a discriminant $D_{n}$ whose list of prime factors contains all the primes of bad reduction for $Y_{1}(n)$. In this paper, we refine and strengthen Morton’s results. Specifically, we exhibit two criteria on a prime $p$ dividing $D_{n}$: one guarantees that $p$ is in fact a prime of bad reduction for $Y_{1}(n)$, yet this same criterion implies that $Y_{0}(n)$ is geometrically irreducible. The other guarantees that the reduction of $Y_{1}(n)$ modulo $p$ is actually smooth. As an application of the second criterion, we extend results of Morton, Flynn, Poonen, Schaefer, and Stoll by giving new examples of good reduction of $Y_{1}(n)$ for several primes dividing $D_{n}$ when $n=7,8,11$, and $f_{c}(x)=x^{2}+c$. The proofs involve a blend of arithmetic and complex dynamics, reduction theory for curves, ramification theory, and the combinatorics of the Mandelbrot set.
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Spencer, Joseph M. "A Moderate Millenarianism: Apocalypticism in the Church of Jesus Christ of Latter-Day Saints." Religions 10, no. 5 (May 25, 2019): 339. http://dx.doi.org/10.3390/rel10050339.
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The Church of Jesus Christ of Latter-Day Saints, the largest and arguably best-known branch of the Restoration movement begun by Joseph Smith, sustains a complex but living relationship to nineteenth-century marginal millenarianism and apocalypticism. At the foundations of this relationship is a consistent interest in the biblical Book of Revelation exhibited in the earliest Latter-Day Saint scriptural texts. The Book of Mormon (1830) affirms that apocalyptic visionary experiences like John’s in the New Testament have occurred throughout history and even contains a truncated account of such a vision. It also predicts the emergence in late modernity of a fuller and uncorrupted account of such an apocalyptic vision, with the aim of clarifying the biblical Book of Revelation. In addition, however, Smith received an apocalyptic vision of his own in 1832 and produced a vision report that suggests that he understood The Book of Mormon’s anticipations of apocalyptic clarification to come as much through ecstatic experience as through the emergence of new apocalyptic texts. In 1842, Smith created a ritualized version of his own apocalyptic experience, a temple liturgy that remains authoritative into the present. This lies behind the moderate apocalypticism of twenty-first century Latter-Day Saint religious experience.
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Maxwell, David, Martin Truffer, Sergei Avdonin, and Martin Stuefer. "An iterative scheme for determining glacier velocities and stresses." Journal of Glaciology 54, no. 188 (2008): 888–98. http://dx.doi.org/10.3189/002214308787779889.
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AbstractThere are no direct methods to measure the boundary condition at the base of a glacier. Here, we propose a method that works by iteratively changing boundary conditions until a satisfactory fit to surface observations is obtained. The method is an accelerated version of one known as Kozlov–Maz’ya iteration. We apply it to the problem of ice flow through a transverse cross-section, and show it to be effective by solving the inverse problem for a sequence of synthetic data. We also apply the method to two real glaciers, Athabasca and Perito Moreno, one of which has a known basal velocity distribution.
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Díaz-Leal, Ana Citlalli, Luis Humberto Blanco Ornelas, Zuliana Paola Benitez Hernández, Susana Ivonne Aguirre Vásquez, and Ramón Candia Luján. "Propiedades psicométricas del Behavioral Regulation in Exercise Questionnaire-2 en universitarios mexicanos (Factor composition of the Behavioral Regulation in Exercise Questionnaire-2 in Mexican university students)." Retos, no. 34 (November 7, 2017): 80–84. http://dx.doi.org/10.47197/retos.v0i34.55794.
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El presente estudio pretende validar las propiedades psicométricas propuestas por Moreno, Cervelló y Martínez (2007) para la versión en español del Behavioral Regulation in Exercise Questionnaire-2 en universitarios mexicanos. Participaron un total de 533 universitarios (M = 20.99 y DS = 2.61 años). La estructura factorial del cuestionario se analizó a través de análisis factoriales confirmatorios, mostrando que una estructura de cuatro factores es viable y adecuada. Los cuatro factores (regulación intrínseca, regulación identificada, regulación introyectada y regulación externa), atendiendo a criterios estadísticos y sustantivos, han mostrado adecuados indicadores de ajuste de fiabilidad y validez; sin embargo, el modelo obtenido no coincide totalmente con el planteado por Moreno y colaboradores, aunque continúa avalando el componente multifactorial de la motivación hacia el ejercicio. Además, la estructura factorial, las cargas factoriales y los interceptos se consideran invariantes entre mujeres y hombres, existiendo diferencias en las puntuaciones entre ambas poblaciones en el factor regulación intrínseca. Futuras investigaciones deberían replicar estos hallazgos en muestras más amplias.Abstract: The current study tries to replicate the psychometric results proposed by Moreno et al. (2007) for the Spanish Version of the Behavioral Regulation in Exercise Questionnaire-2 in Mexican university students. A total of 533 Mexican university students participated in this study (M = 20.99 and SD = 2.61 years). The factor structure of the questionnaire was conducted by confirmatory factor analyses, which showed a feasible and adequate four-factor structure. The four factors (intrinsic regulation, identified regulation, introjected regulation, and external regulation), attending to statistical and substantive criteria, have shown fit indices of reliability and validity; despite not fully coinciding with the model propose by Moreno et al., the obtained model continues giving support to the multifactorial component of motivation towards the exercise. Moreover, the factor structure, loads, and the intercepts were considered as invariables between women and men, obtaining differences in the punctuations of factor intrinsic regulation. Future research should replicate these findings in wider samples.
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Mekenkamp, Marloes. "Narrative Strategies of Criminal Legitimacy." Mexican Studies/Estudios Mexicanos 38, no. 1 (2022): 35–59. http://dx.doi.org/10.1525/msem.2022.38.1.35.
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This article looks at how criminal agents aim to gain legitimacy within the context of the War on Drugs in Mexico. More precisely, it explores the narrative of legitimization presented in Me dicen “el más loco”, an autobiography of Nazario Moreno González, the leader of the criminal organization La Familia Michoacana. A cultural-studies approach is used to argue that the book combines a Christian version of the social-bandit myth with the narrative strategies of the picaresque novel to legitimize the activities of the group. This article aims to contribute to the larger debate on the powerful imaginary dimension of organized crime in Mexico.
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Zeuske, Michael. "The ‘Cimarrón’ in the archives: a re-reading of Miguel Barnet’s biography of Esteban Montejo." New West Indian Guide / Nieuwe West-Indische Gids 71, no. 3-4 (January 1, 1997): 265–79. http://dx.doi.org/10.1163/13822373-90002608.
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[First paragraph]"Aunque por supuesto nuestro trabajo no es historico (Miguel Barnet)" Apart from Manuel Moreno Fraginals's El ingenio, there is hardly any other book in Cuban historiography that has met with such wide circulation as Biografia de un cimarron by Miguel Barnet.1 It is, in spite of a series of contradictions, the classic in testimonio literature for contemporary studies on slavery as well as for the genre of historical slave narratives extending far beyond Cuba. In particular the various new editions and translations, such as the English versions that have been published under the titles Autobiography of a Runaway Slave (Barnet 1968), Autobiography of a Runaway Slave (Esteban Montejo & Miguel Barnet 1993) or Biography of a Runaway Slave (Barnet 1994) and the discussion that Barnet's book stimulated bear witness to this position.2
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Puttabasavaiah, Suneetha, Heshan Liu, Rui Qin, Lisa A. Kottschade, Debra L. Barton, Charles L. Loprinzi, Axel Grothey, Gamini S. Soori, and Jeff A. Sloan. "A comparison of simple single-item measures and the NCI Common Toxicity Criteria version 3.0 measure of peripheral neuropathy." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 1557. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1557.
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1557 Background: Peripheral neuropathy (PN), a common and intrusive side effect of chemotherapy in clinical trials, has been assessed via the clinician-rated common terminology criteria for adverse events (CTCAE) and/or patient-reported outcome (PRO) measures (Morton, ASCO, 2005). We assessed the relative sensitivity of CTCAE and PRO measures for evaluating interventions for preventing and ameliorating CIPN. Methods: Data from285 patients in two prevention trials (N05C3, N04C7) and 432 patients from three intervention trials (N00C3, N01C3, N06CA) were analyzed separately. CTCAE version 3.0 item for neuropathy was compared to 2 NCCTG numerical analogue CIPN items, 6 EORTC CIPN20 individual items, 2 McGill Pain Questionnaire items, and one Brief Pain Inventory item. The sample size provided over 80% power to detect a true Spearman rank correlation of 0.15 assessed the relationship between CTCAE and PRO measures. Results: Results from both the prevention and treatment trials were similar in terms of the relationship between the CTCAE and PRO measures. No correlation coefficients between the CTCAE and any of the PRO items at baseline were above 0.35, with the majority around 0.2. Higher scores for the numbness items were observed than for the CTCAE in 47% of the patients at baseline and 39% during treatment in the treatment trials. Many patients had severe numbness PRO scores but mild CTCAE scores (12%) at baseline and (8%) during treatment in the treatment trials. Results for the numbness and tingling PRO measures were redundant. The correlations of the CTCAE with pain were weak, all below 0.35 at baseline with differences as much as 29 points on average on a 0-100 transformed scale. Conclusions: The CTCAE and PRO measures of PN measure different constructs. The CTCAE includes both functional and ADL/motor aspects which may or may not be related to the singular constructs of pain, numbness, tingling, or adjectival characteristics of pain assessed by the PRO measures. The two measures cannot be used in place of each other.
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Wu, Botao, Zhendong Wang, and Huamin Wang. "A GPU-based multilevel additive schwarz preconditioner for cloth and deformable body simulation." ACM Transactions on Graphics 41, no. 4 (July 2022): 1–14. http://dx.doi.org/10.1145/3528223.3530085.
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In this paper, we wish to push the limit of real-time cloth and deformable body simulation to a higher level with 50K to 500K vertices, based on the development of a novel GPU-based multilevel additive Schwarz (MAS) pre-conditioner. Similar to other preconditioners under the MAS framework, our preconditioner naturally adopts multilevel and domain decomposition concepts. But contrary to previous works, we advocate the use of small, non-overlapping domains that can well explore the parallel computing power on a GPU. Based on this idea, we investigate and invent a series of algorithms for our preconditioner, including multilevel domain construction using Morton codes, low-cost matrix precomputation by one-way Gauss-Jordan elimination, and conflict-free symmetric-matrix-vector multiplication in runtime preconditioning. The experiment shows that our preconditioner is effective, fast, cheap to precompute and scalable with respect to stiffness and problem size. It is compatible with many linear and nonlinear solvers used in cloth and deformable body simulation with dynamic contacts, such as PCG, accelerated gradient descent and L-BFGS. On a GPU, our preconditioner speeds up a PCG solver by approximately a factor of four, and its CPU version outperforms a number of competitors, including ILU0 and ILUT.
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Grala, Krzysztof, and Łukasz Baka. "Polish Adaptation of the Occupational Hardiness Questionnaire (OHQ)." Roczniki Psychologiczne 25, no. 4 (January 18, 2023): 327–47. http://dx.doi.org/10.18290/rpsych2022.18.
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Occupational hardiness is a pattern of attitudes and strategies that stimulates an individual to perceive stressful work situations as controllable, worth dealing with, and contributing to professional development. One of the popular tools in the world to measure this construct is the Occupational Hardiness Questionnaire (OHQ) developed by Moreno-Jiménez et al. It has a three-factor structure, proven construct validity, and good internal consistency. The overarching aim of the study was to prepare a Polish adaptation of the OHQ based on a sample of Polish employees working in health care, education and science, and customer service. The questionnaire-based research was conducted in two stages, with two independent samples. The first study was cross-sectional. Their results were used to estimate the factorial validity, construct validity, and internal consistency of the adapted tool. Participants in the first study were 1,212 employees (originally 1,315) of health care (n = 400), education and science (n = 410), and customer service (n = 400) sectors. The second study, which was longitudinal in nature, included two measurements and was used to estimate test–retest reliability. Of the 400 participants (employees of customer service), 205 completed the questionnaire in two measurements. The Polish version of the OHQ has a three-factor structure, confirmed construct validity and good internal consistency. The Polish version of the OHQ is ideal for scientific research, but can also be used in practice: in career counseling, recruitment, selection, or screening.
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Yáñez Navarro, Celestino. "Obras de Domenico Scarlatti, Antonio Soler y Manuel Blasco [¿de Nebra?] en un manuscrito misceláneo de tecla del Archivo de Música de las Catedrales de Zaragoza." Anuario Musical, no. 67 (December 30, 2012): 45. http://dx.doi.org/10.3989/anuariomusical.2012.67.137.
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El Archivo de Música de las Catedrales de Zaragoza custodia una relevante colección de manuscritos de música de tecla del siglo XVIII. El presente artículo trata por vez primera una de dichas fuentes, miscelánea (E-Zac, A-1 Ms.1), en la que aparecen, junto a numerosas obras anónimas y copias de composiciones de autores destacados del ámbito local e internacional, obras de compositores activos en la corte de Madrid durante los dos últimos tercios del siglo XVIII, tales como Domenico Scarlatti, el padre Antonio Soler, Manuel Blasco [¿de Nebra?], acaso José de Nebra, fray Joaquín Asiaín, [¿Juan de? ] Sesé y José Moreno y Polo. El manuscrito es especialmente interesante no sólo porque compila tres adagios inéditos de Manuel Blasco que hoy se editan, sino por incorporar algunas sonatas de Scarlatti y Soler con llamativas variantes con respecto a las versiones consideradas autorizadas o de referencia, lo cual otorga un valor añadido a este tipo de recopilaciones –sólo hasta ahora “secundarias”–, sin duda destinadas al uso por parte de los organistas activos en el ámbito eclesiástico.
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Usán Supervía, Pablo, and Carlos Salavera Bordás. "Orientaciones de logro, burnout académico y satisfacción intrínseca hacia la escuela en estudiantes de Educación Secundaria Obligatoria." Revista Electrónica Interuniversitaria de Formación del Profesorado 21, no. 3 (September 29, 2018): 19–33. http://dx.doi.org/10.6018/reifop.21.3.311371.
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El objetivo del presente trabajo fue analizar la relación entre las orientaciones de logro, el burnout académico y la satisfacción intrínseca hacia la escuela en una muestra de 1756 alumnos (M=14,47; DT=1,63) pertenecientes a 12 centros de Educación Secundaria Obligatoria (ESO). Los instrumentos utilizados fueron las versiones españolas del Perception of Success Questionnaire (POSQ) (Martínez, Alonso y Moreno, 2006), el Maslach Burnout Inventory–Student Survey (MBI-SS) (Schaufeli et al., 2002) y la Intrinsic Satisfaction Classroom Scale (ISC) (Duda y Nicholls, 2002). Los resultados mostraron relaciones significativas entre las orientaciones de logro hacia la tarea, eficacia académica y diversión en la escuela, en una línea de comportamientos más autodeterminados, así como la relación de las orientaciones de logro hacia el ego con el agotamiento físico/emocional, cinismo y aburrimiento, en otra línea de comportamientos menos autodeterminados. Se desprende la importancia de la promoción de comportamientos adaptativos orientados al esfuerzo, autoeficacia y diversión que mejoren el bienestar y vida académica de los estudiantes en sus centros educativos.
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Le Lay, Matthieu, Agnès Brenot, Joël Gailhard, and Pierre Bernard. "Évolution récente et future de la ressource en eau dans les Alpes. Résultats d’une modélisation hydrologique spatialisée sur le bassin de l’Isère à Grenoble." E3S Web of Conferences 346 (2022): 01028. http://dx.doi.org/10.1051/e3sconf/202234601028.
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Comment évoluent les ressources en eau dans les Alpes sous l’effet du changement climatique ? Diminution de l’enneigement, fonte des glaciers, étiages plus sévères : autant de questions aujourd’hui cruciales pour l’ensemble des usages de l’eau dans ces régions, parmi lesquels la production hydro-électrique. Y répondre suppose à la fois de savoir modéliser finement le fonctionnement de ces hydro-systèmes et de savoir quantifier l’évolution du climat à ces échelles. Une nouvelle version spatialement distribuée du modèle hydrologique MORDOR d’EDF [1] a été déployée sur l’ensemble du bassin versant de l’Isère à Grenoble, en valorisant l’ensemble des données hydro-nivologiques disponibles sur ce bassin (mesures de débit, d’enneigement, images satellites de surfaces enneigées, bilans glaciaires…). Elle a pour objectif de répondre aux nombreux enjeux que pose l’exploitation hydro-électrique de la vallée, en simulant la réponse hydrologique en tout point du bassin et dans différents contextes climatiques. Forcée par des scénarios climatiques préalablement dé-biaisés et régionalisés, elle permet de simuler l’évolution des débits en rivière, les changements de régimes saisonniers, ou encore l’évolution des contributions glaciaires. Autant de données d’entrée précieuses pour quantifier finement les changements déjà observés et adapter au mieux la gestion et l’exploitation des aménagements de la vallée.
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Rey Anacona, César Armando, Nazly Sofía Hernández Acosta, Jaime Humberto Moreno Méndez, Jesús Redondo Pacheco, and Lina María Hernández Cortés. "Prevalence of Dating Violence in Adolescents of Five Colombian Cities." Revista Colombiana de Psicología 31, no. 1 (January 20, 2022): 93–107. http://dx.doi.org/10.15446/rcp.v31n1.86780.
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The aim of this study was to examine the prevalence and frequency of perpetration and victimization of different types of dating violence (DV), among adolescents from 13 to 19 years old in five capital cities of Colombia (Bogotá, Bucaramanga, Ibagué, Tunja, and Yopal), making comparisons by sex. The Spanish version of the Conflict in Adolescent Dating Relationships Inventory was used and various statistical analyses, including the one-way MANOVA, were performed. The results show a high prevalence of DV, particularly verbal/emotional and bi-directional (almost 90 % of the participants), pointing out that sex could have a statistically significant effect on the prevalence of the different types of DV, being higher the proportion of men who perpetrated sexual violence and higher the proportion of women who perpetrated verbal/emotional and physical violence. These results indicate the need to continue investigating the phenomenon in Colombia, to carry out different prevention campaigns that are sensitive to differences by sex in prevalence. How to cite this article: Rey-Anacona, C. A., Hernández Acosta, N. S., Moreno Méndez, J. H., Redondo Pacheco, J., & Hernández Cortés, L. M. (2021). Prevalence of dating violence in adolescents of five Colombian cities. Revista Colombiana de Psicología, 31 (1), 93-107. https://doi.org/10.15446/rcp.v31n1.86780
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Garavaglia, Federico, Matthieu Le Lay, Fréderic Gottardi, Rémy Garçon, Joël Gailhard, Emmanuel Paquet, and Thibault Mathevet. "Impact of model structure on flow simulation and hydrological realism: from a lumped to a semi-distributed approach." Hydrology and Earth System Sciences 21, no. 8 (August 1, 2017): 3937–52. http://dx.doi.org/10.5194/hess-21-3937-2017.
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Abstract. Model intercomparison experiments are widely used to investigate and improve hydrological model performance. However, a study based only on runoff simulation is not sufficient to discriminate between different model structures. Hence, there is a need to improve hydrological models for specific streamflow signatures (e.g., low and high flow) and multi-variable predictions (e.g., soil moisture, snow and groundwater). This study assesses the impact of model structure on flow simulation and hydrological realism using three versions of a hydrological model called MORDOR: the historical lumped structure and a revisited formulation available in both lumped and semi-distributed structures. In particular, the main goal of this paper is to investigate the relative impact of model equations and spatial discretization on flow simulation, snowpack representation and evapotranspiration estimation. Comparison of the models is based on an extensive dataset composed of 50 catchments located in French mountainous regions. The evaluation framework is founded on a multi-criterion split-sample strategy. All models were calibrated using an automatic optimization method based on an efficient genetic algorithm. The evaluation framework is enriched by the assessment of snow and evapotranspiration modeling against in situ and satellite data. The results showed that the new model formulations perform significantly better than the initial one in terms of the various streamflow signatures, snow and evapotranspiration predictions. The semi-distributed approach provides better calibration–validation performance for the snow cover area, snow water equivalent and runoff simulation, especially for nival catchments.
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Waxer, Matthew, and J. Bruce Morton. "Multiple Processes Underlying Dimensional Change Card Sort Performance: A Developmental Electrophysiological Investigation." Journal of Cognitive Neuroscience 23, no. 11 (November 2011): 3267–79. http://dx.doi.org/10.1162/jocn_a_00038.
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Cognitive flexibility follows a protracted developmental trajectory [Morton, J. B. Understanding genetic, neurophysiological, and experiential influences on the development of executive functioning: The need for developmental models. Wiley Interdisciplinary Reviews: Cognitive Science, 2010]. For example, performance and patterns of brain activity associated with the dimensional change card sort (DCCS) show continued age-related changes into early adolescence. According to many theoretical accounts, the DCCS places demands on a single underlying executive process. In the present study, we investigated the possibility that multiple processes unfold within the timeframe of a single DCCS trial through the use of ERPs. Children (n = 40), adolescents (n = 20), and adults (n = 20) performed a modified version of the DCCS with distinct instruction cue- and stimulus-related periods. On any particular trial, the sorting rule either changed (i.e., switch trials) or remained the same (i.e., repeat trials), and the imperative stimulus either embodied conflict (i.e., bivalent stimuli) or did not (i.e., univalent stimuli). Findings were consistent with the hypothesis that multiple distinct executive processes unfold within a single trial. First, for all age groups, rule switching and conflict processing made additive contributions to variability in RT. Second, ERPs time-locked to the instruction cue revealed a late frontal negativity whose amplitude was greater for switch trials relative to repeat trials and that was associated with the magnitude of the behavioral switch cost, whereas ERPs time-locked to the imperative stimulus revealed a fronto-central N2 whose amplitude was greater for bivalent than univalent stimuli and that was associated with the magnitude of the behavioral conflict cost. Finally, switch and conflict-related processes showed distinct developmental trajectories. Taken together, the findings suggest that multiple executive processes underlie DCCS performance and its development. Theoretical implications are discussed.
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Piniella Grillet, Isabel J. "SPAM (An)Archive: Performing under Surveillance." INSAM Journal of Contemporary Music, Art and Technology, no. 9 (December 15, 2022): 99–121. http://dx.doi.org/10.51191/issn.2637-1898.2022.5.9.99.
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Inspired by the attempt to disrupt data gathering and asking ourselves about “spam” digital practices as forms of resistance, the project SPAM (An)Archive brought together the work of the (post)composer and media artist Óscar Escudero and the collective SoundTrieb, whose collaboration took place digitally via Zoom and physically in Switzerland in 2021. Escudero’s collaborative work in the last few years with the (post)composer and musicologist Belenish Moreno-Gil has been fruitful at a sociological and cultural level of analysis, beyond music aesthetics, as they both deal with social networks and digital behavior in their music theater compositions. Using Facebook as a digital stage, SoundTrieb’s version of [Custom #2] (a digital melodrama) allowed performers to develop a double personalization of the piece, intervening their own social media profiles. This paper does not intend to discuss a theoretical approach to these artworks, but their subversive capability. Through a cultural analysis approach, this article recognizes the critical potential against the architecture of digital surveillance that they can achieve, while drawing attention to our complacency to ubiquitous technologies. For this purpose, I introduce notions such as DIY music and coded representation, but I also borrow concepts such as Brigitta Muntendorf’s social composing and Escudero’s spam art. This paper explores, through work examples by all the above-mentioned artists, recent models of compositional work that blur the line between the digital and the physical, the virtual and the real, the private and the public.
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Zulikah, Khusnia, and Adriani Adriani. "PERBEDAAN TEKNIK MORDANTING TERHADAP HASIL PENCELUPAN BAHAN KATUN PRIMISIMA MENGGUNAKAN WARNA ALAM EKSTRAK DAUN LAMTORO (Leucaena leucocephala) DENGAN MORDAN KAPUR SIRIH." Gorga : Jurnal Seni Rupa 8, no. 1 (July 2, 2019): 209. http://dx.doi.org/10.24114/gr.v8i1.13179.
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AbstrakPenelitian ini bertujuan untuk mendiskripsikan: 1) nama warna (hue) 2) gelap terang warna (value) 3) kerataan warna dan 4) perbedaan yang dihasilkan pada pencelupan bahan mori primisima menggunakan warna alam ekstrak daun lamtoro (leucaena leucocephala) dengan mordan kapur sirih sirih. Penelitian ini merupakan penelitian Eksperiment. Data yang digunakan adalah data primer yang bersumber dari 15 orang panelis, kemudian data yang terkumpul diolah dan dianalisis dengan bantuan SPSS (Statistikal Product and Service Solution) versi 16.0 dengan memakai rumus uji friedman K-related sample. Warna yang dihasilkan dengan teknik Pra-mordanting adalah Golden Sundance dengan volume terang dan kerataan warna sangat rata, Mordanting simultan (meta) adalah Golden Sundance dengan volume cukup terang dan kerataan warna cukup rata dan dengan teknik post-Mordanting adalah Golden rod dengan volume kurang terang dan kerataan warna sangat rata. Hasil analisis data yang diperoleh dari uji Friedman K-relatif sample untuk gelap terang warna (value) data yang diperoleh signifikansi sebesar 0,000 < 0,05 = Ho ditolak, artinya terdapat pengaruh yang signifikan terhadap gelap terang warna (value) akibat perbedaan teknik mordanting. Pada kerataan warna data yang diperoleh adalah 0,001 < 0,05 =Ho ditolak. Artinya bahwa terdapat pengaruh yang signifikan akibat penggunaan teknik mordanting.Kata Kunci: mordanting, lamtoro, kapur sirih.AbstractThis study aims to describe: 1) the name of color (hue) 2) the darkness of color (value) 3) the uniformity of color and 4) the differences produced in dyeing the material of primisima using natural color leaves extract of lamtoro (leucaena leucocephala) with mordan lime betel betel This research is a Experiment. The data used are primary data sourced from 15 panelists, then the collected data is processed and analyzed with the help of SPSS (Statistikal Product and Service Solution) version 16.0 using the K-related sample friedman test formula. The color produced by the Pre-mordanting technique is the Golden Sundance with bright volume and very flat evenness, Mordanting simultan (meta) is a Golden Sundance with a fairly bright volume and fairly flat evenness and with post-Mordanting technique is a Golden rod with less bright volume and the color evenness is very flat. The results of data analysis obtained from the Friedman K-relative sample for dark colors (value) data obtained significance 0,000 <0.05 = Ho rejected, meaning that there is a significant effect on dark bright color (value) due to differences in mordanting techniques. On the color flatness of the data obtained 0.001 <0.05 = Ho is rejected. This means that there is a significant effect due to the use of mordanting techniques.Keywords: mordanting, lamtoro, betel lim.
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Bognon-Küss, Cécilia, Bohang Chen, and Charles T. Wolfe. "Metaphysics, Function and the Engineering of Life: the Problem of Vitalism." Kairos. Journal of Philosophy & Science 20, no. 1 (June 1, 2018): 113–40. http://dx.doi.org/10.2478/kjps-2018-0006.
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Abstract Vitalism was long viewed as the most grotesque view in biological theory: appeals to a mysterious life-force, Romantic insistence on the autonomy of life, or worse, a metaphysics of an entirely living universe. In the early twentieth century, attempts were made to present a revised, lighter version that was not weighted down by revisionary metaphysics: “organicism”. And mainstream philosophers of science criticized Driesch and Bergson’s “neovitalism” as a too-strong ontological commitment to the existence of certain entities or “forces”, over and above the system of causal relations studied by mechanistic science, rejecting the weaker form, organicism, as well. But there has been some significant scholarly “push-back” against this orthodox attitude, notably pointing to the 18th-century Montpellier vitalists to show that there are different historical forms of vitalism, including how they relate to mainstream scientific practice (Wolfe and Normandin, eds. 2013). Additionally, some trends in recent biology that run counter to genetic reductionism and the informational model of the gene present themselves as organicist (Gilbert and Sarkar 2000, Moreno and Mossio 2015). Here, we examine some cases of vitalism in the twentieth century and today, not just as a historical form but as a significant metaphysical and scientific model. We argue for vitalism’s conceptual originality without either reducing it to mainstream models of science or presenting it as an alternate model of science, by focusing on historical forms of vitalism, logical empiricist critiques thereof and the impact of synthetic biology on current (re-)theorizing of vitalism.
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Zhou, J. N., S. Y. Liu, Y. F. Chen, and L. S. Liao. "First Report of Pantoea anthophila Causing Soft Rot Disease in Clausena lansium (Wampee) in China." Plant Disease 99, no. 3 (March 2015): 416. http://dx.doi.org/10.1094/pdis-10-14-1025-pdn.
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Clausena lansium, also known as wampee (Clausena wampi), is a plant species native to China, Vietnam, the Philippines, Malaysia, and Indonesia, where it is widely cultivated, and also grown in India, Sri Lanka, Queensland, Florida, and Hawaii, but less frequently (3). The fruit can be consumed fresh or made into juice, jam, or succade. In summer to fall 2014, a soft rot disease was found in a wampee planting region in Yunan County, Guangdong Province, China. On Sept. 18, we collected diseased samples from a wampee orchard with about 20% disease incidence. The infected fruit initially showed pinpoint spots on the peel, water-soaked lesions, and light to dark brown discoloration. Spots expanded in 2 days, and tissues collapsed after 5 days. Severely affected fruit showed cracking or nonodorous decay. Five diseased samples were collected, and causal agents were isolated from symptomatic tissues 1 cm under the peel after surface sterilization in 0.3% NaOCl for 10 min and rinsing in sterile water three times. Tissues were placed on a Luria Bertani (LB) plate for culture. Ten representative isolates were selected for further characterization. No colony was isolated from healthy tissues. Colonies were round, smooth, with irregular edges, and produced a yellow pigment in culture. Biolog identification (Version 4.20.05) showed that all strains were gram negative, negative for indole production, and utilized glucose, maltose, trehalose, sucrose, D-lactose, and pectin but not sorbitol or gelatin. The isolates were identified as Pantoea agglomerans (SIM 0.69). Multilocus sequence analysis (MLSA) was conducted for rapid classification of the strains. Sequences of atpD, gyrB, infB, and rpoB were amplified using corresponding primers (2). All sequences of the 10 isolates were identical in each gene. BLASTn was performed, and maximum likelihood trees based on the concatenated nucleotide sequences of the four genes were constructed using MEGA6. Bootstrap values after 1,000 replicates were expressed as percentages. Results showed that the tested strain named CL1 was most homologous to P. anthophila, with 98% identity for atpD (KM521543), 100% for gyrB (KM521544), infB (KM521545), and rpoB (KM521546). The 16S rRNA sequence (KM521542) amplified by primers 27f and 1492r shared 99% identity with that of P. anthophila M19_2C (JN644500). P. anthophila was previously reclassified from P. agglomerans (3); therefore, we suggest naming this wampee pathogen P. anthophila. Subsequently, 10 wampee fruits were injected with 20 μl of bacterial suspension (1 × 108 CFU/ml) of strains CL1 and CL2, respectively, and another 10 were injected with 20 μl of LB medium as controls, all kept at 28°C for 4 days. Symptoms similar to those of natural infections were observed on inoculated fruits but not on the negative controls. Bacteria were isolated from diseased tissues and further identified as P. anthophila by gyrB sequencing. P. anthophila was reported to naturally infect balsam and marigold (1,2). To our knowledge, this is the first report of P. anthophila naturally causing soft rot disease and cracking on C. lansium (wampee). References: (1) C. Brady et al. Syst. Appl. Microbiol. 31:447, 2008. (2) C. Brady et al. Int. J. Syst. Evol. Microbiol. 59:2339, 2009. (3) J. Morton. Fruits of Warm Climates. Echo Point Books & Media, Miami, FL, 1987.
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De Paula Gusmão, Priscilla, Rayssa Ferreira Diniz Fernandes, Rhávila Cristina Rezende, Rodrigo De Souza Bonfim, Yuri Viktor Porto, Luciana Caetano Fernandes, and Léa Resende Moura. "Perfil epidemiológico de uma população de usuários de drogas de Anápolis, Goiás - Epidemiological profile of a population of drug users in the city of Anápolis, Goiás." Revista Educação em Saúde 5, no. 1 (June 26, 2017): 28. http://dx.doi.org/10.29237/2358-9868.2017v5i1.p28-37.
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ResumoObjetivos: Descrever o perfil sociodemográfico e o padrão de uso de drogas de internos de clínicas de reabilitação do município de Anápolis e entorno. Método: Estudo transversal, observacional, descritivo e quantitativo. Participaram os internos de sete clínicas de reabilitação localizadas em Anápolis. Os dados foram coletados por meio de um roteiro semiestruturado elaborado pelos pesquisadores Para verificar a associação entre as variáveis categóricas foi utilizado o Teste Qui-quadrado, com correções de LikelihoodRatio. O nível de significância utilizado foi p< 0,05. Os dados foram analisados no Software StatisticalPackage Social Science (SPSS, versão 21). Resultados: Todos os 144 participantes eram homens, com idade média de 37,4 anos (DP ±11,6), sendo que 79 (54,9%) eram solteiros e goiana, 67 (46,5%) eram pardo/moreno com renda familiar variando entre 1 a 3 salários mínimos. As drogas mais utilizadas foram álcool (79,9%), seguida do tabaco (64,4%) e cocaína/crack (57,6%). 15 (10,4%) já injetaram drogas e a maioria (60%) destes já compartilhou seringa/agulhas. Quatorze participantes (9,7%) fizeram uso de nove tipos diferentes de drogas no ano anterior à internação. Conclusões: Revelou-se a importância em traçar o perfil sóciodemográfico e o padrão de uso de drogas a fim de estabelecer políticas públicas de prevenção e tratamento para este público vigente.Palavras-chave:Comportamento de procura de droga. Perfil de Saúde. Saúde Pública. Transtornos relacionados ao uso de Substâncias. AbstractObjective: To describe the sociodemographic profile and the drug use pattern of rehabilitation centers in Anápolis and surroundings. Method: A cross-sectional, observational, descriptive and quantitative study. The research evaluated 144 drugs addicts in 7 centers from Anápolis and surroundings. The data was collected by objective and structured questionnaires elaborated by the researchers. The Chi-square test was used to verify the association among the categorical variables, and corrections by LikelihoodRatio. The significance level adopted was p<0,05. The software Statistical Package Social Science (SPSS, version 21) analyzed the data. Results: All patients were men, with an age average of 37,4 years old (DP ±11,6), 79 (54.9%) were unmarried from Goiás, and 67 (46.5%) whad brown skin with income Family ranging from 1 to 3 minimum wages. The main drugs used were alcohol (79,9%), followed by tobacco (64,4%) and cocaine/crack (57,6%). Fifteen patients (10,4%) had already injected drugs and most of them (60%) had already shared needles. Fourteen patients (9,7%) used 9 different kinds of drugs in the year before hospitalization. Conclusions: It was revealed the importance of outlining the socio-demographic profile and the pattern of drug use in order to establish public policies of prevention and treatment for this current public.Keyword:Drug-SeekingBehavior. Public Health. Health Profile. Substance-related disorders.
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Garcia Guerrero, Estefania, Jose Antonio Pérez Simon, Luis Ignacio Sánchez Abarca, Irene Diaz Moreno, Miguel Angel De la rosa, and Antonio Diaz Quintana. "Molecular Dynamics As a Computational Tool to Study the Immune Reactivity: Identification of Conformational Changes in the Major Histocompatibility Complex." Blood 124, no. 21 (December 6, 2014): 2735. http://dx.doi.org/10.1182/blood.v124.21.2735.2735.
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Abstract Introduction: The generation of the immune response requires the recognition of peptides presented by the major histocompatibility complex (MHC) through the T cell receptor (TCR). In the hematopoietic transplantation context, T cells (LT) from the donor recognize foreign MHC or own MHC bound to foreign peptides (pMHC), generating an alloimmune response. Currently, the molecular mechanisms of LT alloimmune activation are unknown. In order to analyze the molecular interactions between peptides, MHC and TCR, we have implemented Molecular Dynamics techniques. We have compared immunologically reactive complexes (HLA-A2/TAX/TCR-A6) to non/weakly reactive complexes (HLA-A2/V7R/TCR-A6; HLA-A2/P6A/TCR-A6; HLA-A2/Y8A/TCR-A6). Methods: Starting structure of a reactive complex was downloaded from the PDB database and used to model mutations known to lead to different degrees of immune reactivity. Dynamics simulations were performed and analyzed using the program AMBER version 9. The simulation time was approximately 10 ns. Further analysis was carried out using the script ARO (Díaz-Moreno et al. 2009) in the VMD Tk console. Results: A total of 10 MD trajectories have been reckoned, to simulate the behavior of isolated components of the different pMHC-TCR complexes. Analysis of the fluctuations show that pMHC binding barely restrains TCR motions, affecting mostly to CDR3 loops. Opposite, pMHC displayed substantial changes in its dynamics upon comparing its free versus ternary form (pMHC-TCR). Moreover, we studied the salt-bridges formed between peptide and MHC and we observed a significant loss of salt-bridges in non reactive complexes as compared to reactive ones. Furthermore, the loss of salt-bridges in non reactive complexes affects the electrostatic potential of pMHC complex. According to these results, we next studied the salt-bridges formed between pMHC and TCR. As observed within the binary complex p-MHC, we confirmed a significant loss of salt-bridges in non reactive as compared to reactive complex. Finally, we also analyzed the electrostatic potential of pMHC-TCR complexes and we observed differences between reactive complex and weakly/non reactive complexes. Conclusions: The MHC shows strong changes in its molecular dynamics upon binding to TCR, decreasing its mobility. The “pattern” of salt-bridges between the peptides and the MHC varies depending on the reactivity of the complex, with a loss of salt-bridges in the non-reactive as compared to the reactive ones, which results in change in the electrostatic pattern. In addition, also the number of salt-bridges between pMHC and TCR increases in reactive complexes as compared to non-reactive ones. Disclosures No relevant conflicts of interest to declare.
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Guerrero, Estefania Garcia, Irene Diaz Moreno, Miguel Angel De la rosa, Jose Antonio Pérez Simón, and Antonio Diaz Quintana. "Molecular Dynamics As a Computational Tool To Analyze Lymphocyte Alloreactivity In Hematopoietic Transplant Recipients." Blood 122, no. 21 (November 15, 2013): 1049. http://dx.doi.org/10.1182/blood.v122.21.1049.1049.
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Abstract Introduction The generation of the immune response requires the recognition of peptides presented by the major histocompatibility complex (MHC) through the T cell receptor (TCR). In the hematopoietic transplantation context, T cells (LT) from the donor recognize foreign MHC or own MHC bound to foreign peptides (pMHC), generating an alloimmune response. Currently, the molecular mechanisms of LT alloimmune activation are unknown. In order to analyze the molecular interactions between peptides, MHC and TCR, we have implemented Molecular Dynamics techniques. We have compared immunologically reactive complexes (HLA-A2/TAX/TCR-A6; HLA-A2/HUD/TCR-A6) to non/weakly reactive complexes (HLA-A2/V7R/TCR-A6; HLA-A2/P6A/TCR-A6; HLA-A2/Y8A/TCR-A6). Methods Starting structures of two reactive complexes were downloaded from the PDB database and used to model mutations known to lead to different degrees of immune reactivity. Dynamics simulations were performed and analyzed using the program AMBER version 9. The simulation time was approximately 10 ns. Further analysis was carried out using the script ARO (Díaz-Moreno et al. 2009) in the VMD Tk console. Results A total of 17 MD trajectories have been reckoned, to simulate the behavior of isolated components of the different MHC-TCR complexes. Analysis of the fluctuations shows that pMHC binding barely restrains TCR motions, affecting mostly to CDR3 loops. Opposite, pMHC displayed substantial changes in its dynamics upon comparing its free versus ternary form (pMHC-TCR). Furthermore, taking as reference the positions of the MHC´s helices in free binary structures (MHC-peptide) and comparing them to the positions in ternary structures (pMHC-TCR), we can observe that in reactive complexes MHC exhibits a higher variability than in non-reactive complexes, suggesting that the MHC must tighten and acquire a position further away from its position in free binary form. We also analyzed the position of the peptide in the groove of MHC and we found that at position 5 (aa aromatic) the peptide is diverted although its position in the groove of MHC seems to be unrelated to the reactivity of the interaction TCR-pMHC. Conclusions The MHC shows strong changes in its molecular dynamics upon binding TCR, decreasing its mobility. The structure of MHC is slightly perturbed in reactive complexes, but not in non-reactive ones. Financial support Spanish MINECO (BFU2009-07190/BMC, BFU2012-31670/BMC) the Andalusian Government (BIO198) and Instituto de Salud Carlos III (PFIS - FI12/00189 and FIS PI11/02366) Disclosures: No relevant conflicts of interest to declare.
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Chumsri, Saranya, Pooja P. Advani, Tanmayi S. Pai, Zhou Li, Marites Acampora, Gina A. Reynolds, Alvaro Moreno-Aspitia, Christopher P. Marquez, and Keith L. Knutson. "Abstract P3-23-01: Antibody responses after SARS-CoV-2 mRNA vaccination in breast cancer patients." Cancer Research 82, no. 4_Supplement (February 15, 2022): P3–23–01—P3–23–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-23-01.
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Abstract Background: SARS-CoV-2 mRNA vaccines have been demonstrated to have robust and durable humoral immune response in healthy individuals. However, their effectiveness in immunocompromised patients, particularly cancer patients, remains less known. Newer data suggests that cancer patients may not mount adequate protective immune response after vaccination. Methods: A retrospective study of patients ≥ 18 years old who had SARS-CoV-2 spike antibody (anti-S Ab) testing after 2 doses of SARS-CoV-2 mRNA vaccines between 12-90 days at Mayo Clinic between January 1, 2021 and May 10, 2021 was performed. The Elecsys Anti-SARS-CoV-2 S electrochemiluminescence immunoassay (Roche Diagnostics, Switzerland) was used to measure the antibody response. Patients with prior COVID-19 infection and patients on immunosuppressive therapy for an indication other than cancer were excluded. Categorical variables were summarized as frequencies (percentages) and continuous variables were reported as median with range. Wilcoxon signed rank test was used to compare continuous variables between groups and Chi-squared or Fisher’s exact test was used to compare categorical variables. All tests were two-sided with p value < 0.05 considered statistically significant. The analysis was done using R program version 3.6.2. Results: Among 201 patients, 79 had breast cancer, 91 had a hematologic malignancy, 6 had other solid malignancies, and 25 had no history of cancer. All breast cancer patients on endocrine therapy or trastuzumab ± pertuzumab without chemotherapy (n=35) had anti-S Ab titer ≥ 500 U/mL. Patients on cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) appeared to have low level of anti-S Ab with 28.6% (n=4/14) had anti-S Ab titer ≤ 500 U/mL. Patients on chemotherapy also had low levels of anti-S Ab with 47% (n=14/30) having anti-S Ab titers ≤ 500 U/mL. When combining breast cancer patients on endocrine therapy alone or anti-HER2 therapy with patients without history of cancer as an immunocompetent group, there was significantly greater proportion of immunocompetent patients (97%) who had anti-S Ab titer ≥ 500 U/mL compared with only 8% of patients with hematologic malignancy and 55% of patients with solid malignancy on chemotherapy or CDK4/6i (p < 0.001). Using multivariate logistic regression analysis adjusted for age, gender, and vaccine type, patients with solid malignancies and treatment-related cytopenia, including chemotherapy and CDK4/6i, (OR 35.51 [95%CI 8.38-255.25, p < 0.001]) were more likely than immunocompetent patients to have a suboptimal anti-S Ab results ≤ 500 U/mL.Conclusion: A significant number of breast cancer patients on chemotherapies and CDK4/6i had poor humoral responses after SARS-CoV-2 mRNA vaccination. While CDK4/6i is not commonly considered as immunosuppressive therapy, breast cancer patients on CDK4/6i appeared to have suboptimal response to SARS-CoV-2 mRNA vaccine. Our study also highlights the significance of assessing antibody response after COVID-19 vaccines in these vulnerable patients. Citation Format: Saranya Chumsri, Pooja P. Advani, Tanmayi S Pai, Zhou Li, Marites Acampora, Gina A Reynolds, Alvaro Moreno-Aspitia, Christopher P Marquez, Keith L. Knutson. Antibody responses after SARS-CoV-2 mRNA vaccination in breast cancer patients [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P3-23-01.
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Iakovlieva, L. V., O. G. Berdnik, and A. A. Gurtyakova. "Analysis of assortment and volumes of consumption of antihistamin preparations in Ukraine." Farmatsevtychnyi zhurnal, no. 1-2 (August 14, 2018): 12–21. http://dx.doi.org/10.32352/0367-3057.1-2.18.02.
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Over the past 30 years, the prevalence of allergic diseases has doubled every 10 years. According to WHO, currently about 5% of the world's adult population and 15% of children suffer from allergic diseases.
The purpose of the study is to analyze the assortment of antihistamines in the pharmaceutical market of Ukraine, determine the availability for consumers by the indicator of Ca.s. and their volumes of consumption by ATS/DDD-methodology during 2014‒2017.
Represented in the pharmaceutical market of Ukraine antihistamines were analyzed according to the analytical system of research of the pharmaceutical market «Pharmstandard» of the company «MORION». As an indicator of socio-economic accessibility of antihistamines, an indicator of the adequacy of the solvency of Ca.s. Volumes of consumption of antihistamines were examined using the WHO recommended ATC/DDD methodology. Information on the DDD values is available on the WHO website: www.who.int/countries/ukr.
During the period under study, there was a decrease in the number of TNs against the background of an increase in the number of INNs of all three generations. The quantitative ratio of domestic and foreign producers has not changed significantly.
Based on the results of the Ca.s. found that antihistamines for the population of Ukraine for all four years are mainly high-availability drugs. And only 14.29% of fexofenadine preparations (in 2014) and 3.22% of desloratadine preparations (in 2015) are medium-accessible. The low indicator of the adequacy of solvency (Ca.s.) to 5%, confirms the availability of drugs group R06 and guarantees their consumption in the face of a decline in economic development in Ukraine.
The most consumed during the studied four years were LS of five INNs: Mebrogroline, Cetirizine, Loratadine, Levocetirizine and Desloratadine, related to all three generations of antihistamines. Consumption of this group of the most used drugs during the study period was 89.94%, 90.64%, 90.70% and 90.47%, respectively, over the years of total consumption of antihistamines.
During 2014‒2017 there is a decrease in the number of TN drugs against the background of an increase in the number of INN: from 172 TN on the basis of 16 INN in 2014 to 160 TN on the basis of 17 INNs in 2017. The quantitative ratio of domestic and foreign producers has not changed significantly. The assortment of antihistamine drugs for 2017 is quite wide. On the pharmaceutical market of Ukraine are represented drugs of all three generations. Depending on the manufacturer, the prices varied from low to high, namely the spread of prices from 1.65 UAH to 212.43 UAH in 2014 and from 4.76 UAH to 567.63 UAH in 2017, which made it possible to select individual drugs taking into account the active ingredients, dosage form and price.
According to the results of the Ca.s indices, it is established that antihistamines for the population of Ukraine for the entire four years are represented mainly by high-availability TN. And only 14.29% of fexofenadine preparations (in 2014) and 3.22% of desloratadine preparations (in 2015) are medium-accessible. The low indicator of the adequacy of solvency (Ca.s.) to 5%, confirms the availability of drugs group R06 and guarantees their consumption in the face of a decline in economic development in Ukraine.
According to the analysis of the consumption of antihistamines in DDDs/1000 inhabitants/day, the increase in the consumption of these drugs was observed every year from 9.64 in 2014 to 10.60 in 2017. At the same time, the consumption of the latest generation drugs increased: INN desloratadine (from 0.98 in 2014 to 1.27 in 2017) and INN levocetirizine (from 1.91 in 2014 to 2.53 in 2017), which have profitable pharmacokinetic characteristics and the optimal efficiency / safety ratio. The consumption of second-generation drugs remains stably large: loratadine (2.62 in both 2014 and 2017), cetirizine (from 1.78 in 2014 to 1.94 in 2017). Along with sufficiently high pharmacological activity, they have a relatively low cost, since they are mainly presented in the pharmaceutical market in the form of generic versions.
Against the background of the trend of increasing consumption of antihistamines in Ukraine over the last four years (from 9.64 DDDs/1000 inhabitants/day in 2014 to 10.60 DDDs/1000 inhabitants/day in 2017), it is established that in Ukraine there is a large number patients who do not receive in full, or do not receive quality adequate antihistamine therapy at all.
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Agarwal, Rajat Kumar, Rakesh Dhanya, Stalin Ramprakash, C. P. Raghuram, Pallavi Mehta, Deepa Trivedi, Shruthi Jayapal, Sandeep S, and Lawrence Faulkner. "Peripheral Blood to Marrow Collection White Cell Count Ratio As an Indicator of Harvest Quality and Transplant Outcomes in G-CSF-Primed Marrow Grafts." Blood 134, Supplement_1 (November 13, 2019): 4473. http://dx.doi.org/10.1182/blood-2019-125111.
Full textAbstract:
Background: G-CSF-primed bone marrow (G-BM) is used in some centers as the product of choice in related donor transplants because of lower rates of GVHD and fast engraftment (Morton 2001; Deotare et al. 2015). Marrow collections substantially diluted with peripheral blood may, however, compromise the GVHD-sparing effect of G-BM. Concerns over the variability in the quality of bone marrow harvest have been reported (Spitzer et al. 1994; Prokopishyn et al. 2019). We explored the role of a simple novel quality indicator, i.e peripheral blood to marrow harvest WBC ratio, as a predictor of GVHD risk. Materials and methods: We analysed 156 successive bone marrow harvests for patients suffering from severe thalassemia using G-BM donated by fully matched (10/10 or 12/12) related donors (143 siblings and 13 mothers) at Sankalp-People Tree Centre for Paediatric BMT - Bangalore (80 patients) and Sankalp-CIMS Centre for Paediatric BMT - Ahmedabad (76 patients). G-CSF priming was done for 5 days before the transplant with 10 mcg/kg/day in 2 divided subcutaneous doses and peripheral counts were obtained within 24 hours of collection. G-BM was collected in bags with 20 ml 50 U/ml heparin for the first 200 ml and further 10ml/100ml of marrow. We defined quality of marrow as follows: Quality of Marrow = WBC count of G-CSF primed BM / Peripheral WBC count of donor Quality of Marrow < 0.9 was categorised as poor as it signifies that the concentration of WBCs in bone marrow is same or lesser than the pre-harvest peripheral counts. EBMT criteria was used for grading GVHD. We calculated the odds of aGVHD based upon the quality of marrow. Beside marrow quality, the sex of the recipient seemed to impact GVHD rates and thus regression analysis was used to study the impact of G-BM quality independent of other factors. Statistics were performed on R software (version 3.5.x). Mann Whitney and Fisher's exact tests were used to compare numeric and categorical data respectively. Results: Of the 156 harvests, 18 had poor marrow quality; 33% (6 of 18) of these developed acute GVHD grade II-IV as opposed to 9% (13 of 138) (see Figure 1). Between those who developed GVHD and those who did not, marrow quality (p=0.012), patient sex (p=0.006) and sex mismatch status (p=0.014) were significantly different. Differences in total cell dose (p=0.65), transplant centre (p=0.62), bone marrow cell count (p=0.14) and peripheral cell count before harvest (p=0.72), donor age at BMT (p=0.42), relationship with the donor (p=1.0) and average volume of marrow per draw of syringe (p=0.23) showed no statistical significance. Variables with significant difference (sex mismatch and bone marrow quality) were entered in the Cox's proportional hazards model for acute GVHD II-IV which showed that poor marrow quality is the most significant independent risk associated with a hazard ratio of 3.6 (p=0.009), followed by male to male transplants which were associated with a hazard ratio of 10.6 (p=0.03) See Table 1. Further, poor quality marrow was associated with lower cell count in marrow (p<0.001), higher peripheral counts (p<0.001), higher collection volume (p=0.035) and was seen more in one centre compared to the other (p<0.001). Donor age (p=0.81), donor's relationship (p=1.0), donor sex (0.62), donor's carrier status (p=0.64), donor weight (p=0.85) and average volume of marrow per draw of syringe (p= 0.76) were not statistically significant. Discussion: The role of tolerance induced by mesenchymal stem cells in reduction (Aggarwal 2005) and even the treatment of GVHD (Le Blanc et al. 2004; Baron and Storb 2012) has been reported elsewhere and supports our findings though this is yet to be established (Fisher et al. 2019). Simple quality control of BM could be highly beneficial in all settings in minimising acute GVHD. This is particularly important in low- and middle-income countries where GVHD can be very challenging (Saleem et al. 2018) and is associated with high costs of management and prolonged hospitalisation (Grubb et al. 2016). Our indicator is accurately measurable, inexpensive, precise and timely; further it does not involve any sophisticated equipment (flow cytometry for CD counts), thus may be widely applicable and usable. Conclusion: Quality of BM harvest, as indicated by PB to BM WBC ratio, is a simple, effective and inexpensive informative indicator in the context of G-BM. Poorer quality of marrow collection may be contributing to increased risk of acute GVHD. Disclosures No relevant conflicts of interest to declare.
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Giancane, G., R. Papa, S. Vastert, F. Bagnasco, J. F. Swart, P. Quartier, M. Hofer, et al. "OP0164 LONG-TERM SAFETY OF ANAKINRA IN PATIENTS WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS FROM THE PHARMACHILD REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 98.2–99. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1731.
Full textAbstract:
Background:Systemic juvenile idiopathic arthritis (SJIA) is characterized by extra-articular manifestations, as fever and rash, and rarely associated by a potentially lethal complication as macrophage activation syndrome (MAS). Anakinra is a recombinant human interleukin (IL)-1 receptor antagonist whose efficacy and safety profile has been studied for patients with SJIA.Objectives:To evaluate the long-term safety profile of anakinra in patients with SJIA.Methods:Data from patients with SJIA enrolled in the Pharmachild registry before 30 September 2018 and treated with anakinra were analyzed. The study endpoints were the occurrence of non-serious adverse events (AEs) of at least moderate severity and serious AEs (SAEs), including macrophage activation syndrome (MAS), and the duration of anakinra treatment with reasons for discontinuation. All endpoints were analyzed overall, by 6 month-time windows and in different treatment sets represented by those patients continuously treated with anakinra for at least 12, 18 and 24 months (set-12, -18, -24, respectively).Results:306 patients were enrolled. 46%, 34% and 28% of them had been treated for at least 12, 18 and 24 months, respectively. 201 AEs, mostly represented by infections, were reported for 509.3 patient-years (py) with an overall incidence rate (IR) of 39.5/100 py. Among 56 SAEs (IR 11.0/100 py), (Table 1) 23.2% were infections and 19.6% MAS episodes. The IR of AEs was higher during the first 6 months of anakinra, followed by decreasing IR in the different long-term treatment sets. Treatment discontinuation occurred in 76% of patients, most in the first 6 months, due to inefficacy (43%), remission (31%) or AEs/intolerance (15%). No deaths or malignancies occurred during anakinra treatment.Table 1.Number of SAEs and incidence rates (95% CI) by overall PT decreasing order and time window in the complete set (events with a frequency >1 by overall SOC and >1 by overall PT were reported) Only time windows <13 months were reported in the present table.Time window1-6 months7-12 monthsOverallN306194306Patient-time (years)117.380.2509.3SOCPTnRate (95% CI)nRate (95% CI)nRate(95% CI)AllAll3328.1 (19.1-41.5)45.0 (1.9-13.2)5611.0 (7.9-15.2)Infections and infestationsAll76.0 (2.9- 12.4)11.2 (0.2- 8.8)132.6 (1.4- 4.8)Pneumonia21.7 (0.4- 6.8)11.2 (0.2- 8.8)40.8 (0.3- 2.1)Immune system disordersAll76.0 (2.8- 12.5)11.2 (0.2- 8.8)112.2 (1.1- 4.1)Haemophagocytic lymphohistiocytosis76.0 (2.8- 12.5)11.2 (0.2- 8.8)112.2 (1.1- 4.1)Injury, poisoning and procedural complicationsAll54.3 (1.8- 10.2)--91.8 (0.9- 3.4)Infusion related reaction10.9 (0.1- 6.0)--20.4 (0.1- 1.6)Injection related reaction43.4 (1.3- 9.1)--61.2 (0.5- 2.6)Metabolism and nutrition disordersAll32.6 (0.8- 7.9)--40.8 (0.3- 2.1)Skin and subcutaneous tissue disordersAll32.6 (0.8- 7.9)11.2 (0.2- 8.8)40.8 (0.3- 2.1)Blood and lymphatic system disordersAll10.9 (0.1- 6.1)--20.4 (0.1- 1.6)General disorders and administration site conditionsAll10.9 (0.1- 6.1)11.2 (0.2- 8.8)20.4 (0.1- 1.6)InvestigationsAll21.7 (0.4- 6.8)--20.4 (0.1- 1.6)Nervous system disordersAll10.9 (0.1- 6.0)--20.4 (0.1- 1.6)Surgical and medical proceduresAll10.9 (0.1- 6.0)--20.4 (0.1- 1.5)Abbreviations: SAE, serious adverse event; SOC, system organ class; PT, preferred term, MedDRA version 21.1; N, number of patients ever treated with anakinra during the time window irrespectively of the length of any unexposed periods; 95% CI, 95% Confidence Interval.Conclusion:The results of the present study confirm the long-term safety profile of anakinra in SJIA patients and show a decreasing overall incidence rate of AEs over time.Disclosure of Interests:Gabriella Giancane Grant/research support from: The study was funded by SOBI Swedish, Riccardo Papa Grant/research support from: The study was funded by SOBI Swedish, Sebastian Vastert Grant/research support from: The study was funded by SOBI Swedish, Francesca Bagnasco Grant/research support from: The study was funded by SOBI Swedish, Joost F. Swart Grant/research support from: The study was funded by SOBI Swedish, Pierre Quartier Grant/research support from: The study was funded by SOBI Swedish, michael hofer Grant/research support from: The study was funded by SOBI Swedish, Jordi Anton Grant/research support from: The study was funded by SOBI Swedish, Sylvia Kamphuis Grant/research support from: The study was funded by SOBI Swedish, Helga Sanner Grant/research support from: The study was funded by SOBI Swedish, Mia Glerup Grant/research support from: The study was funded by SOBI Swedish, Fabrizio De Benedetti Grant/research support from: The study was funded by SOBI Swedish, Elena Tsitsami Grant/research support from: The study was funded by SOBI Swedish, Agustin Remesal Grant/research support from: The study was funded by SOBI Swedish, Estefania Moreno Ruzafa Grant/research support from: The study was funded by SOBI Swedish, Jaime de Inocencio Grant/research support from: The study was funded by SOBI Swedish, Charlotte Myrup Grant/research support from: The study was funded by SOBI Swedish, Chiara Pallotti Grant/research support from: The study was funded by SOBI Swedish, Isabelle Koné-Paut Grant/research support from: The study was funded by SOBI Swedish, Karin Franck-Larsson Employee of: I am employee of SOBI pharmaceutical company, Hakan Malmstrom Employee of: I am employee of SOBI pharmaceutical company, Susanna Cederholm Employee of: I am employee of SOBI pharmaceutical company, Angela Pistorio Grant/research support from: The study was funded by SOBI Swedish, Nico Wulffraat Grant/research support from: The study was funded by SOBI Swedish, Nicolino Ruperto Speakers bureau: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers and Squibb, Celgene, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Hoffmann-La Roche,Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB., Consultant of: NR has received honoraria for consultancies or speaker bureaus (< 10.000 USD each) from the following pharmaceutical companies in the past 3 years: Ablynx, Astrazeneca-Medimmune, Bayer, Biogen, Boehringer, Bristol Myers and Squibb, Celgene, Eli-Lilly, EMD Serono, Glaxo Smith and Kline, Hoffmann-La Roche,Janssen, Merck, Novartis, Pfizer, R-Pharma, Sinergie, Sobi and UCB., Grant/research support from: The IRCCS Istituto Giannina Gaslini (IGG), where NR works as full-time public employee has received contributions (> 10.000 USD each) from the following industries in the last 3 years: BMS, Eli-Lilly, GlaxoSmithKline, F Hoffmann-La Roche, Janssen, Novartis, Pfizer, Sobi. This funding has been reinvested for the research activities of the hospital in a fully independent manner, without any commitment with third parties.
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Reynolds, Peter. "Christian Wolff, et al. - ‘PIANIST: PIECES’: CHRISTIAN WOLFF. CD1: For Pianist: For Piano I; Suite (I); For Prepared Piano; For Piano II; For Piano With Preparations; For Pianist. CD2: Long Piano (Peace March 11). CD3: Pianist Pieces; A Piano Piece; Nocturnes 1-6; Small Preludes; Touch. Philip Thomas (pno). Sub Rosa SR389 - ‘TWO PIANOS AND OTHER PIECES, 1953–1969’: MORTON FELDMAN. CD 1: Two Pianos; Four Instruments; Vertical Thoughts 1; Between Categories; Piece for Four Pianos; Piano Four Hands. CD2: Intermission 6; De Kooning; Two Pieces for Three Pianos; Piano Three Hands; False Relationships and the Extended Ending; Two Pianos second version. John Tilbury, Philip Thomas, Catherine Laws & Mark Knoop (pno), Anton Lukoszevieze & Seth Woods (vc), Mira Benjamin & Linda Jankowska (vln), Rodrigo Constanzo & Taneli Clarke (perc.), Barrie Webb (tromb.), Naomi Atherton (hn). Another Timbre at81 × 2 - ‘THE WIND IN HIGH PLACES’: JOHN LUTHER ADAMS. The Wind in High Places1; Canticles of the Sky2; Dream of the Canyon Wren3. 1,3JACK Quartet, 2Northwestern University Cello Ensemble c. Hans Jørgen Jensen. Cold Blue Music CB0041." Tempo 69, no. 273 (July 2015): 41–43. http://dx.doi.org/10.1017/s0040298215000169.
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