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Journal articles on the topic 'Morpholines – chemical synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Reddy, B. Jayachandra, and M. C. Somasekhara Reddy. "Ultrasonicated Synthesis ofN-Benzyl-2,3-substituted Morpholines, via the Mitsunobu Diol Cyclisation." E-Journal of Chemistry 7, no. 4 (2010): 1184–89. http://dx.doi.org/10.1155/2010/931015.

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A facile five step synthesis ofN-benzyl-2,3-substituted morpholines (i-iii) was performed. The key steps were microwave assisted Friedel-crafts acylation and diol cyclization carried out via an ultra sonication of Mitsunobu reaction using DEAD (diethylazodicarboxylate), TPP in THF for 1 h. The morpholine products were generated as diasteriomers (iiandiii) which has been separated by the column chromatography to good yield. The structure of compounds (i-iii) has been characterized by the spectral and chemical studies.

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2

Magerramov, A. M., M. N. Magerramov, Kh A. Makhmudova, and G. I. Alizade. "Synthesis of N-Substituted Oxazolidines and Morpholines." Russian Journal of Applied Chemistry 78, no. 8 (2005): 1301–5. http://dx.doi.org/10.1007/s11167-005-0502-x.

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3

Beng, Timothy K., Abdikani Omar Farah, and Victoria Shearer. "Modular synthesis and transition metal-free alkynylation/alkenylation of Castagnoli–Cushman-derived N,O- and N,S-heterocyclic vinyl chlorides." RSC Advances 10, no. 61 (2020): 37153–60. http://dx.doi.org/10.1039/d0ra06619b.

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A functional group-tolerant and transition metal-free coupling of novel N,O- and N,S-heterocyclic vinyl chlorides, which affords fully carbosubstituted dihydro-1,4-oxazines/thiazines as well as bicyclic morpholines, is described.

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4

Cera, Gianpiero, Michel Chiarucci, and Marco Bandini. "Accessing chemical diversity by stereoselective gold-catalyzed manipulation of allylic and propargylic alcohols." Pure and Applied Chemistry 84, no. 8 (2012): 1673–84. http://dx.doi.org/10.1351/pac-con-11-09-05.

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The combined use of asymmetric Au(I) catalysis with allylic as well as propargylic alcohols proved to be a competent synthetic tool, toward the realization of complex molecular organic architectures in a stereochemically defined manner. In particular, allylic alcohols have been utilized as alkylating agents in the synthesis of tetrahydrocarbazoles/carbolines and morpholines by means of new C–C and C–X bond-forming processes. Analogously, the direct activation of indole-propargylic alcohols with cationic Au complexes opened a direct access to tetracyclic fused indolines in a highly stereoselect

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5

Rasulov, Ch K., A. G. Azizov, F. A. Nabiev, S. T. Rustamov, and A. S. Askerova. "Synthesis of N-[2-hydroxy-4(5)-methyl- and -5-(methylcyclohexyl)benzyl]morpholines as antioxidants for transformer oils." Russian Journal of Applied Chemistry 83, no. 12 (2010): 2140–43. http://dx.doi.org/10.1134/s107042721012013x.

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6

Journal, Baghdad Science. "Synthesis, Characterization and Study the Biological Activity of New Morpholine Derivative." Baghdad Science Journal 12, no. 4 (2015): 761–73. http://dx.doi.org/10.21123/bsj.12.4.761-773.

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A new series of morpholine derivative were prepared by reacting the morpholine with ethyl chloro acetate in the presence triethylamine as an catalyst and benzene as a solvent gave the ethyl morpholin-4-ylacetate reaction with hydrazine hydrate and ethanol as a solvent gave the 2-(morpholin-4-yl)acetohydrazide gave series of Schiff base were prepared by reacting 2-(morpholin-4- yl)acetohydrazide with different aromatic aldehydes and ketons . The new series of (3-9 )were synthesis by reaction of Schiff base (10-14) with chloroacetyl chloride, triethyl amine as an catalyst and 1,4dioxane as a sol

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7

D’hooghe, Matthias, Stijn Dekeukeleire, Erika Leemans та Norbert De Kimpe. "Use of functionalized β-lactams as building blocks in heterocyclic chemistry". Pure and Applied Chemistry 82, № 9 (2010): 1749–59. http://dx.doi.org/10.1351/pac-con-09-09-39.

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β-Lactams represent flexible building blocks suitable for the preparation of a large variety of nitrogen-containing target compounds. In the present study, the formerly neglected synthetic potential of 4-haloalkyl-β-lactams has been elaborated in detail with a focus on the preparation of different mono- and bicyclic heterocycles. A first approach involved ring transformations of these halogenated building blocks toward stereodefined aziridines, azetidines, pyrrolidines, and piperidines via intermediate aziridinium or azetidinium ions. In a second part, novel and stereoselective entries into 1,

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8

Hermecz, István, Andrea Sánta-Csutor, Csaba Gönczi, et al. "Chemical development of the vasopressin receptor 2 antagonist SR-121463." Pure and Applied Chemistry 73, no. 9 (2001): 1401–9. http://dx.doi.org/10.1351/pac200173091401.

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A facile convergent total synthesis of the selective, potent, and orally active V2 non-peptide antagonist, SR-121463, was developed by modification of the discovery route. One of the late intermediates, the sulfonyl chloride 1, was synthesized from 3-hydroxybenzoic acid (19) by regioselective sulfonation, O-methylation and amidation in four steps. Another late intermediate, indolin-2-one 2, was prepared from p-phenetidine (8) through the indolin-2-one 16, where the cyclohexanone moiety of 27 was introduced into the active 3-methylene group of 16 by sequential transformation using methyl acryla

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9

Kumar, Praveen, Jai Prakash Kumar, Juhi Barnwal, and Ritu Singh. "Design, Synthesis and Molecular Docking Studies of 4-{3-[2-(2-Morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol-1-yl}-benzenesulfonamide as Anti-Breast Cancer Agent." Asian Journal of Organic & Medicinal Chemistry 5, no. 4 (2020): 301–6. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p271.

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Novel 4-{3-[2-(2-morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol- 1-yl}benzenesulfonamide (7) was synthesized and evaluated for its anti-breast cancer activity. It was prepared by cyclocondensation reaction of morpholine-substituted β-diketone, 1-[2-(2-morpholin-4-yl-ethoxy)- phenyl]-3-phenyl-propane-1,3-dione (3) with 4-hydrazinobenzenesulfonamide hydrochloride (6). Chemical structure of titled compound (7) was confirmed by FTIR, 1H & 13C NMR and HRMS spectroscoic analyses. The anticancer activity of titled compound 7 was evaluated against MCF-7 breast cancer cell line by MTT assay. Molecu

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10

Barker, David, Benjamin Dickson, Nora Dittrich, and Claire E. Rye. "An acyl-Claisen approach to the synthesis of lignans and substituted pyrroles." Pure and Applied Chemistry 84, no. 7 (2012): 1557–65. http://dx.doi.org/10.1351/pac-con-11-09-27.

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The acyl-Claisen rearrangement, also called a zwitterionic aza-Claisen rearrangement, allows for the synthesis of 2,3-syn-substituted morpholine pent-4-eneamides with high levels of diastereoselectivity. A wide variety of alkyl and aryl substituents can be introduced with yields highly dependent on the stoichiometry of the Lewis acid catalyst. The use of these morpholine amides in the synthesis of the tetrasubstituted tetrahydrofuran lignans fragransin A2, talaumidin, and galbelgin is summarized. The conversion of the Claisen-derived amides into aryl tetraline and 1,1-diarylbutanol lignans via

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11

Wang, Dan, Yifu Wang, Heting Wan, Jilin Wang, and Lulu Wang. "Synthesis of gemini basic ionic liquids and their application in anion exchange membranes." RSC Advances 8, no. 19 (2018): 10185–96. http://dx.doi.org/10.1039/c8ra00594j.

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A gemini-type basic morpholine ionic liquid ([Nbmd][OH]) was synthesizedviaa two-step method with morpholine, bromododecane and 1,4-dibromobutane as raw materials, and its structure was characterized by<sup>1</sup>H NMR and FT-IR spectroscopy.

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12

Shi, Qian-Ping, Zhi-Hao Shi, Nian-Guang Li, et al. "Efficient Chemical Synthesis of a Scutellarein Derivative Containing Morpholine Ring." Letters in Organic Chemistry 11, no. 8 (2014): 590–95. http://dx.doi.org/10.2174/1570178611666140421230118.

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13

Nikitin, Evgeny, Georgy Shumatbaev, Dmitriy Terenzhev, Kirill Sinyashin, and Egor Rastergaev. "New Sintanyl Phosphonates for Protection of Oil and Gas Pipelines from Steel Corrosion." Civil Engineering Journal 5, no. 4 (2019): 789–95. http://dx.doi.org/10.28991/cej-2019-03091288.

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Many corrosion inhibitors are economically disadvantageous or toxic to the environment. Additionally, there are certain requirements for corrosion inhibitors. Therefore, the development of new corrosion inhibitors is one of the important problems in the oil-producing and oil-refining industry. The purpose of this work is the synthesis of new corrosion inhibitors with high inhibitory activity, the establishment of the structure of the compounds obtained and the determination of the anti-corrosion effect with respect to aggressive media. This paper presents the results of research on the develop

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14

Liu, Chunjing, Benyi Li, and Lester Mitscher. "Synthesis of New TGX-221 Analogs." Zeitschrift für Naturforschung B 69, no. 7 (2014): 817–22. http://dx.doi.org/10.5560/znb.2014-4081.

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TGX-221 is a potent phosphoinositide 3-kinase (PI3K)β inhibitor that has great therapeutic potential to treat prostate cancer. Chemical modification of TGX-221 at positions 2 and 9 was made. Five new TGX-221 analogs with different heterocyclic substituents of morpholine, 1-methylpiperazine, aniline, and thiazole-2-amine at positions 2 and 9 were synthesized. Parallel synthetic methods were employed in SN2 replacement reactions at positions 2 and 9 of TGX-221.

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15

Al-Wasidi, Asma S., Nawal M. Al-Jafshar, Amal M. Al-Anazi та ін. "Electron-transfer complexation of morpholine donor molecule with some π – acceptors: Synthesis and spectroscopic characterizations". Polish Journal of Chemical Technology 21, № 4 (2019): 82–88. http://dx.doi.org/10.2478/pjct-2019-0043.

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Abstract Morpholine is an interesting moiety that used widely in several organic syntheses. The intermolecular charge-transfer (CT) complexity associated between morpholine (Morp) donor with (monoiodobromide “IBr”, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone “DDQ”, 2,6-dichloroquinone-4-chloroimide “DCQ” and 2,6-dibromoquinone-4-chloroimide “DBQ”) π–acceptors have been spectrophotometrically investigated in CHCl3 and/or MeOH solvents. The structures of the intermolecular charge-transfer (CT) were elucidated by spectroscopic methods like, infrared spectroscopy. Also, different analyses techniques

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16

Ahmadi, Abbas, Mohsen Khalili, Ramin Hajikhani, and Moslem Naserbakht. "New morpholine analogues of phencyclidine: Chemical synthesis and pain perception in rats." Pharmacology Biochemistry and Behavior 98, no. 2 (2011): 227–33. http://dx.doi.org/10.1016/j.pbb.2010.12.019.

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17

Cámara, Fernando, Linda Pastero, Rossella Arletti, and Monica Cagnoni. "A novel layered aluminophosphate with corner-sharing AlO6chains." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C993. http://dx.doi.org/10.1107/s2053273314090068.

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The synthesis, Raman spectroscopy and crystal structure of a novel layered aluminophosphate is described. The new phase was derived by the sol-gel method starting from a modified low hydrothermal ALPO4-34 zeolite synthesis procedure[1].The structure was solved by direct methods using single-crystal X-ray diffraction. The synthesized layered material, with composition [AlPO3(OH)F(H2O)]-(H9C4ON), crystallizes in the monoclinic space group P21/a with a = 9.2282(5) Å, b = 6.9152(4) Å, c = 14.4615(9) Å, β = 101.57(1)0. Layered aluminophosphates with AlO6polyhedra have been previously described [2],

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18

Yien, Yvette Y., Caiyong Chen, Jiahai Shi, et al. "Fam210b Is Required for Optimal Cellular and Mitochondrial Iron Uptake during Erythroid Differentiation." Blood 126, no. 23 (2015): 405. http://dx.doi.org/10.1182/blood.v126.23.405.405.

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Abstract Red cells synthesize large quantities of heme during terminal differentiation. Central to erythropoiesis is the transport and trafficking of iron within the cell. Despite the importance of iron transport during erythroid heme synthesis, the molecules involved in intracellular trafficking of iron are largely unknown. In a screen for genes that are up-regulated during erythroid terminal differentiation, we identified FAM210B, a predicted multi-pass transmembrane mitochondrial protein as an essential component of mitochondrial iron transport during erythroid differentiation. In zebrafish

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19

Kravchenko, Dmitri V., Volodymyr M. Kysil, Alexey P. Ilyn, et al. "Synthesis and Chemical Transformations of 6‐(Morpholine‐4‐sulfonyl)‐quinoline‐2,3,4‐tricarboxylic Acid." Synthetic Communications 36, no. 7 (2006): 911–17. http://dx.doi.org/10.1080/00397910500466165.

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20

Trabocchi, Andrea, Duccio Cavalieri, and Antonio Guarna. "Chemical genetics approach to drug discovery by diversity-oriented synthesis (DOS) of peptidomimetics." Pure and Applied Chemistry 83, no. 3 (2011): 687–98. http://dx.doi.org/10.1351/pac-con-10-09-30.

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Chemical genetics, which relies on selecting small molecules for their ability to induce a biological phenotype or to interact with a particular gene product, is a new powerful tool for lead generation in drug discovery. Accordingly, diversity-oriented synthesis (DOS) of small-molecule peptidomimetics gives access to collections of new chemotypes bearing high structural diversity. Biological evaluation using cell growth as a phenotypic screening on Saccharomyces cerevisiae deletant strains is a powerful tool to identify new chemotypes as hit compounds in the discovery of new antifungal and ant

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21

Kanagarajan, V., J. Thanusu, and M. Gopalakrishnan. "A Green Chemical Approach towards the 'One-Pot' Synthesis, Spectral Characterization and in Vitro Antibacterial and Antifungal Activities of Morpholino Pyrimidines." Journal of the Korean Chemical Society 53, no. 6 (2009): 731–41. http://dx.doi.org/10.5012/jkcs.2009.53.6.731.

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22

Kanagarajan, Vijayakumar, Jayaraman Thanusu, and Mannathusamy Gopalakrishnan. "Design, Synthesis and Spectral Characterization of Novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides." Journal of the Korean Chemical Society 54, no. 1 (2010): 49–54. http://dx.doi.org/10.5012/jkcs.2010.54.01.049.

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23

Fonseca, Renilma S. P., Fernando C. Silva, Francisco S. M. Sinfrônio, Caritas de J. S. Mendonça, and Inocêncio S. dos S. Neto. "SYNTHESIS OF MORPHOLINE-BASED IONIC LIQUIDS FOR EXTRACTIVE DESULFURIZATION OF DIESEL FUEL." Brazilian Journal of Chemical Engineering 36, no. 2 (2019): 1019–27. http://dx.doi.org/10.1590/0104-6632.20190362s20180107.

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24

Sperlich, Jörg, Joachim Becht, Mathias Mühleisen, Stephan A. Wagner, Günter Mattern, and Reinhold Tacke. "Zwitterionische Bis[vic-arendiolato(2 –)] [(morpholinio)alkyl]silicate: Synthese sowie strukturelle Charakterisierung in Lösung und im Kristall / Zwitterionic Bis[vic-arenediolato(2 –)] [(morpholinio)alkyl]silicates: Synthesis and Structural Characterization in Solution and in the Crystal." Zeitschrift für Naturforschung B 48, no. 12 (1993): 1693–706. http://dx.doi.org/10.1515/znb-1993-1201.

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The zwitterionic A5-spirosilicates bis[1,2-benzenediolato(2–)][(morpholinio)methyl]silicate (1), bis[2,3-naphthalenediolato(2–)][(morpholinio)methyl]silicate (2; isolated as 2 • CH3CN), bis[1,2-benzenediolato(2–)][3-(morpholinio)propyl]silicate (3) and bis[2,3-naphthalenediolato(2 –)][3-(morpholinio)propyl]silicate (4; isolated as 4·1/2CH3CN) have been synthesized by various methods including Si – C bond cleavage reactions. The crystal structures of 2 • CH3CN and 4 · 1/2 CH3CN have been determined. 1,2 • CH3CN, 3 and 4 · 1/2 CH3CN have also been characterized by solution-state (1H, 13C, 29Si)

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25

Tiwari, Shailee V., Julio A. Seijas, M. Pilar Vazquez-Tato, and Anna Pratima G. Nikalje. "Ultrasound Assisted Synthesis of Diethyl (2-(1-(morpholinomethyl)-2-Oxoindolin-3-ylidene)hydrazinyl) (Substituted Phenyl/heteryl) MethylphosphonateDerivatives." Proceedings 9, no. 1 (2018): 3. http://dx.doi.org/10.3390/ecsoc-22-05790.

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This work reports ultrasound assisted synthesis diethyl (2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazinyl) (substituted phenyl/heteryl) methylphosphonate 9(a–j) derivatives. The derivatives are synthesized using a green protocol. In the first step, 3-hydrazonoindolin-2-one is synthesized using ultrasound. In the second step, diethyl (substituted phenyl/heteryl)(2-(2-oxoindolin-3-ylidene)hydrazinyl) methylphosphonate 6(a–j) derivatives are synthesized using cerric ammonium nitrate as catalyst. In the third step, diethyl (2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazinyl) (subst

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26

Buron, Frédéric, Nuno Rodrigues, Thibault Saurat, et al. "Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors." Molecules 26, no. 17 (2021): 5349. http://dx.doi.org/10.3390/molecules26175349.

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This work describes the synthesis, enzymatic activities on PI3K and mTOR, in silico docking and cellular activities of various uncommon 2,4,7 trisubstituted pyrido[3,2-d]pyrimidines. The series synthesized offers a chemical diversity in C-7 whereas C-2 (3-hydroxyphenyl) and C-4 groups (morpholine) remain unchanged, in order to provide a better understanding of the molecular determinants of PI3K selectivity or dual activity on PI3K and mTOR. Some C-7 substituents were shown to improve the efficiency on kinases compared to the 2,4-di-substituted pyrimidopyrimidine derivatives used as references.

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27

Sánchez García, Jessica J., Marcos Flores-Alamo, Mark E. Martínez Klimov, and Elena I. Klimova. "N-alkyl-2-(1,2-diferrocenylvinyl)-4,5-dihydrooxazolinium salts, multi-component synthesis and breaking of their heterocyclic systems." Pure and Applied Chemistry 88, no. 12 (2016): 1129–42. http://dx.doi.org/10.1515/pac-2016-0812.

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AbstractA new multicomponent method for the synthesis of N-alkyl-2-(Z-1,2-diferrocenylvinyl)-4,5-dihydrooxazolinium salts 3a–f, 5-(N-alkyl-2′,3′-diferrocenyl-acryloylamido)-3-aza-3-alkylpentanols 4a–d, (E)-N-alkyl-N-(2-morpholinoethyl)-2,3-diferrocenylacrylamides 9a,b,e,f and (E)-N-alkyl-N-(2-piperidinoethyl)-2,3-diferrocenylacrylamides 10a,c from reactions of 2,3-diferrocenylcyclopropenone 1 with bis-1,4-N,O-nucleophiles in the presence of triethyloxonium tetrafluoroborate, alkyl iodides, morpholine, piperidine and Et3N is described. The characterization of the new compounds was done by IR, 1

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28

Grbović, Ljubica, Bojana Radovan Vasiljević, Ksenija Pavlović, et al. "Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions." Macedonian Journal of Chemistry and Chemical Engineering 37, no. 1 (2018): 13. http://dx.doi.org/10.20450/mjcce.2018.1371.

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Within the field of green chemistry, a noticeable results were obtained in the solvent-free synthesis of amide derivatives of naphthenic acids under microwave irradiation. Naphthenic acid amides, anilides, and morpholides were synthesized directly from free carboxylic acids and amines in the absence of solvent and catalyst under high-temperature heating in a closed-vessel system of microwave reactor. With this new and efficient method, different primary, secondary, and tertiary amide derivatives of naphthenic acids were obtained in good to excellent yields. Synthesized derivatives were assayed

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29

Kanagarajan, V., and M. Gopalakrishnan. "Morpholino pyrimidinyl acetamides: design, green chemical one-pot synthesis, and in vitro microbiological evaluation." Pharmaceutical Chemistry Journal 45, no. 3 (2011): 170–77. http://dx.doi.org/10.1007/s11094-011-0586-y.

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30

Patel, K. C., S. N. Kaula, and P. S. Patel. "Synthesis and Physico-Chemical Properties of 2-Morpholino-4,6-Dichloro-S-Triazine with Various Aromatic Diols." High Performance Polymers 8, no. 2 (1996): 265–73. http://dx.doi.org/10.1088/0954-0083/8/2/007.

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Several homopolycyanurates were synthesized by stirred interfacial polycondensation of 2-morpholino-4,6-dichloro- s-triazine with various aromatic diols such as 1,5- dihydroxynaphthalene,(DHN-1,5),1,7-dihydroxynapthalene(DHN-1,7),2,7-dihydroxynapthalene resorcinol (R), catechol (C), hydroquinone (H) and phenolphthalein (Ph). They were characterized by density, viscosity measurements, IR spectra, solubility tests and thermogravimetric analysis. The polymer had reduced viscosities in the range 0.468 to 0.829 dl g−1 in chromoform at 30 °C. All the polymers were amorphous and soluble in chlorinate

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31

Hassanain, Hawazen, E. Stephen Davies, William Lewis, Deborah L. Kays, and Neil R. Champness. "Morpholino-Substituted BODIPY Species: Synthesis, Structure and Electrochemical Studies." Crystals 10, no. 1 (2020): 36. http://dx.doi.org/10.3390/cryst10010036.

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Functionalization of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) chromophores at the 2,6-positions with iodo substituents and morpholino-substituted α-methyl groups affords molecules with strong absorbance in the visible spectrum. The effect of such substitution on the solid-state arrangements, absorption, fluorescence and electronic properties of these dye molecules is reported. The spectroscopic and spectroelectrochemical measurements display intense absorptions in the UV-visible spectrum with bathochromic shifts, in comparison to unfunctionalized BODIPY, and a positive shift in redo

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32

Parra, Marilyn, Xiuli An, Narla Mohandas, and John G. Conboy. "In Vivo Analysis of Erythroid Protein 4.1 Pre-mRNA Splicing Mechanisms: Use of Antisense Morpholinos to Assay Function of Deep Intron Regulatory Elements." Blood 116, no. 21 (2010): 815. http://dx.doi.org/10.1182/blood.v116.21.815.815.

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Abstract Abstract 815 Erythroid stage-specific alternative splicing plays an essential role in the expression of protein 4.1R isoforms that interact with other skeletal proteins to strengthen the membrane. In late erythroblasts, 4.1R mRNA is processed from pre-mRNA that initiates transcription at alternative first exon 1A (E1A) and splices exclusively to the more distal of two alternative 3' splice sites at exon 2 (E2dis), ~100kb downstream. This splicing event is important because it is required to generate the shorter N-terminal domain characteristic of 80kDa isoforms of 4.1R protein in red

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33

El-Samahy, Fatma A., Hayam A. Abd El Salam, Naglaa F. El-Sayed, Elsayed M. Shalaby, and Mahmoud F. Dondeti. "Synthesis of unexpected novel bis-coumarin derivatives via three component reactions of 4-hydroxycoumarin, aldehydes and cyclic secondary amines. Conformation in the solid state and pharmacological evaluation." Zeitschrift für Naturforschung B 72, no. 10 (2017): 705–16. http://dx.doi.org/10.1515/znb-2017-0066.

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AbstractA series of unexpected bis-coumarins have been synthesized by multicomponent reactions of 4-hydroxycoumarin, aldehydes, and cyclic secondary amines in ethanol at room temperature. The chemical structures of new compounds were identified by 1H, 13C NMR, and mass spectrometry. Furthermore, the molecular structure of the solid-state adduct of 3,3′-[(4-methoxyphenyl)-methylene]bis(4-hydroxy-2H-chromen-2-one) with morpholine (1:1) has been confirmed by single-crystal X-ray diffraction. The cytotoxicity of the new coumarin derivatives against MCF7 breast cancer cells was evaluated. A docking

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34

García, L., J. Palazón, J. Gálvez, and G. López. "Synthesis and thermal behaviour of morpholine complexes with cobalt (II) and manganese (II) thiocyanates." Journal of Thermal Analysis 35, no. 1 (1989): 113–20. http://dx.doi.org/10.1007/bf01914270.

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35

Enchev, D. D. "Synthesis and Chemical Behavior of the N-Morpholino- O-Alkyl-3-Methyl-1,2-Butadienephosphonic Acid Esters." Phosphorus, Sulfur, and Silicon and the Related Elements 180, no. 9 (2005): 2131–35. http://dx.doi.org/10.1080/104265090917637.

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36

Enchev, D. D. "SYNTHESIS AND CHEMICAL BEHAVIOR OF THE N-MORPHOLINO-O-ALKYL-3-METHYL- 1,2-BUTADIENEPHOSPHONIC ACID ESTERS." Phosphorus, Sulfur, and Silicon and the Related Elements 134, no. 1 (1998): 431–36. http://dx.doi.org/10.1080/10426509808043620.

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37

Enchev, D. D. "Synthesis and Chemical Behavior of the N-Morpholino-O-Alkyl-3-Methyl-1,2-Butadienephosphonic Acid Esters." Phosphorus, Sulfur, and Silicon and the Related Elements 134, no. 1 (1998): 431–36. http://dx.doi.org/10.1080/10426509808545484.

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38

Biçak, Niyazi, A. Bahattin Soydan, and Sedat Çakaloğlu. "Synthesis of N-allyl morpholine and its copolymers with sulfur dioxide and styrene." Designed Monomers and Polymers 1, no. 3 (1998): 305–13. http://dx.doi.org/10.1163/156855598x00035.

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39

Djigoue, Guy Bertrand, and Donald Poirier. "Introducing Molecular Diversity at the C20-position of Pregnenolone by the Formation of Spiro-2-morpholinones." Current Organic Synthesis 15, no. 4 (2018): 541–51. http://dx.doi.org/10.2174/1570179414666171107161304.

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Aim and Objective: The development of small molecules that can interact with key therapeutic target represents an active field of research. Therefore, new approaches for increasing the molecular diversity of a starting material, such as a natural product, are needed. Herein, the carbonyl group present on a pregnane scaffold, or easily obtained from the oxidation of the corresponding alcohol, was used to obtain a series of diversified steroidal morpholinone derivatives. Materials and Methods: Using chemical synthesis, two levels of molecular diversity were introduced at position 20 of a C21-ste

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40

Khanra, Tapan Kumar, Basudam Adhikari, and Sukumar Maiti. "Multifunctional Activities of Benzazole Derivatives in Rubber Vulcanization." Rubber Chemistry and Technology 66, no. 1 (1993): 30–37. http://dx.doi.org/10.5254/1.3538297.

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Abstract Benzazole thiol (e.g. 2-Mercaptobenzothiazole and 2-Mercaptobenzimidazole) and sulfenamide (e.g. 2-Morpholino thiobenzothiazole) are used as rubber chemicals. The nature and the extent of their performances in rubber depend on the nature of the key heteroatom present in the azole ring. It has been found that the presence of X (S or N) as the key heteroatom in the grouping —X—‖—SH of the azole ring is responsible for either accelerator or antioxidant action. Although some scattered informations on accelerator and antioxidant functions are available for some of the benzazole derivatives

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41

Meenarathi, B., P. Siva, M. Jeyapriya, R. Baskaran та R. Anbarasan. "Synthesis, Characterization, Catalytic Reduction, and Splinting Activity of Poly(ε-caprolactone-co -morpholine)/Ag Nanocomposite". Advances in Polymer Technology 37, № 2 (2016): 390–98. http://dx.doi.org/10.1002/adv.21678.

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42

Soliman, Saied M., Hessa H. Al-Rasheed, and Ayman El-Faham. "Synthesis, X-ray Structure, Hirshfeld Analysis of Biologically Active Mn(II) Pincer Complexes Based on s-Triazine Ligands." Crystals 10, no. 10 (2020): 931. http://dx.doi.org/10.3390/cryst10100931.

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Herein, the synthesis and antimicrobial activities of [Mn(MorphBPT)(H2O)2NO3]NO3; (1) and [Mn(PipBPT)(H2O)2NO3]NO3; (2) complexes of the pincer-type tridentate ligands MorphBPT; 4-(4,6-di(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine and PipBPT; 2-(piperidin-1-yl)-4,6-di(1H-pyrazol-1-yl)-1,3,5-triazine are presented. Both complexes have slightly distorted octahedral coordination geometry. Their molecular packing depends on O–H···O, C–H···O hydrogen bonds and anion–π stacking contacts. Hirshfeld analysis was used to quantify the different contacts. Both complexes exhibited better anti-fungal a

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43

Abu-Hashem, Ameen Ali, Sami A. Al-Hussain, and Magdi E. A. Zaki. "Synthesis of Novel Benzodifuranyl; 1,3,5-Triazines; 1,3,5-Oxadiazepines; and Thiazolopyrimidines Derived from Visnaginone and Khellinone as Anti-Inflammatory and Analgesic Agents." Molecules 25, no. 1 (2020): 220. http://dx.doi.org/10.3390/molecules25010220.

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Novel (4-methoxy or 4,8-dimethoxy)-3-methyl-N-(6-oxo-2-thioxo-1,2,3, 6-tetrahydro- pyrimidin-4-yl) benzo [1,2-b: 5, 4-b’] difuran-2-carboxamide (5a–b) has been synthesized by the reaction of visnagenone–ethylacetate (2a) or khellinone–ethylacetate (2b) with 6-aminothiouracil in dimethylformamide or refluxing of benzofuran-oxy-N-(2-thioxopyrimidine) acetamide (4a–b) in sodium ethoxide to give the same products (5a,b) in good yields. Thus, compounds 5a–b are used as an initiative to prepare many new heterocyclic compounds such as 2-(4-(3-methylbenzodifuran- 2-carbox-amido) pyrimidine) acetic aci

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44

Khezami, Khaoula, Kevser Harmandar, Esra Bağda, et al. "The new water soluble zinc(II) phthalocyanines substituted with morpholine groups- synthesis and optical properties." Journal of Photochemistry and Photobiology A: Chemistry 401 (October 2020): 112736. http://dx.doi.org/10.1016/j.jphotochem.2020.112736.

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45

Agarwal, R., M. H. Ansari, M. W. Y. Khan, M. Ahmad, and K. D. Sharma. "Synthesis and antimicrobial activity of fatty 2-morpholinones prepared from epoxy fatty acid methyl esters." Journal of the American Oil Chemists' Society 66, no. 6 (1989): 825–27. http://dx.doi.org/10.1007/bf02653677.

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46

Palazón, J., J. Gálvez, G. García, and G. López. "Synthesis and thermal study of some adducts of morpholine with nickel(II) nitrite, sulphate and perchlorate." Journal of Thermal Analysis 32, no. 2 (1987): 645–52. http://dx.doi.org/10.1007/bf01912717.

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47

Ma, Da-You, Li-Chao Zhang, Kun-Jian Peng, et al. "7-O-aminoalkyl-2,3-dehydrosilibinins: Synthesis and in vitro Anti-cancer Efficacy." Anti-Cancer Agents in Medicinal Chemistry 18, no. 8 (2018): 1156–62. http://dx.doi.org/10.2174/1871520618666180402122713.

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Background: The heptaprotective flavonolignan silibinin and dehydrosilibinin have exhibited moderate antiproliferative activities toward many cancer cell lines. Considering of the nontoxic profile of these natural products, chemical modification to enhance the anticancer potentials is promising. Method: A series of 7-O-aminoalkyl-2,3-dehydrosilibinin derivatives were synthesized and evaluated for their antiproliferative activities against several cancer cell lines. Results: A number of the synthesized dehydrosilibinin derivatives exhibited greatly enhanced potency with 50% growth inhibition at

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Barakat, Assem, Saied M. Soliman, Matti Haukka та ін. "One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone". Crystals 10, № 4 (2020): 282. http://dx.doi.org/10.3390/cryst10040282.

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One-pot synthesis of three enaminones, (E)-1-(4-chlorophenyl)-3-morpholinoprop-2-en-1-one 1, (E)-1-(4-chlorophenyl)-3-(4-methylpiperazin-1-yl)prop-2-en-1-one 2, and (E)-1-(4-chlorophenyl)-3-(pyrrolidin-1-yl)prop-2-en-1-one 3 were achieved. The synthetic protocol via three components reaction of p-chloroacetophenone with DMFDMA (N,N-dimethylformamid-dimethylacetal) and the corresponding secondary amines (morpholine/N-methylpiperazine/pyrrolidine) in dioxane under heating for 2.5–4 h at 102 °C yielded the requisite enaminones. This protocol has the advantage of no separation of intermediate, no

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49

Zhou, Chuanzheng, Wimal Pathmasiri, Dmytro Honcharenko, Subhrangsu Chatterjee, Jharna Barman, and Jyoti Chattopadhyaya. "High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions." Canadian Journal of Chemistry 85, no. 4 (2007): 293–301. http://dx.doi.org/10.1139/v07-025.

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During the F–-promoted deprotection of the oligo–RNA, synthesized using our 2′-O-(4-tolylsulfonyl)ethoxymethyl (2′-O-TEM) group [Org. Biomol. Chem. 5, 333 (2007)], p-tolyl vinyl sulphone (TVS) is formed as a by-product. The TVS formed has been shown to react with the exocyclic amino functions of adenosine (A), guanosine (G), and cytidine (C) of the fully deprotected oligo–RNA to give undesirable adducts, which are then purified by HPLC and unambiguously characterized by 1H, 13C Heteronuclear Multiple Bond Correlation (HMBC) NMR and mass spectroscopic analysis. The relative nucleophilic reactiv

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50

Suhak, O. A., О. I. Panasenko, and Ye G. Knysh. "Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 48–54. http://dx.doi.org/10.32352/0367-3057.2.17.06.

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Derivatives of 1,2,4-triazole are inherent in various types of biological activity. They can be used as pesticide and medicinal drugs (anticonvulsants, analgetics, antitumor and antibacterial). In this regard the search of new methods of synthesis and investigation of biological activity of 2-(4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-ylthio)acetate acids and their salts is relevant nowadays. With the aim of finding the new biologically active compounds 2-(4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-ylthio)acetate acids and their salts are synthesized, where R is methyl, ethy

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