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1
Knoefel, Mark-Ulrich. "Age-related morphological changes in fifth cervical vertebrae." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0018/MQ47050.pdf.
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2
Hula, V. I. "Morphological changes of stomach influenced by general dehydration." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45950.
Full textAbstract:
It is well known that the digestive system is very sensitive to a large number of different negative factors. In particular, frequent lesions in the stomach is exposed as its organ and the main reservoir of mechanical and chemical processing of food. It is necessary to say that the effect of dehydration of the stomach has not been adequately studied. The significant amount of water and electrolytes is deposited in the gastrointestinal tract and is involved in the exchange, circulating between blood and content of the digestive tract. That is why the aim of this thesis was to discover structural and morphological changes in stomach due to the total dehydration.
3
Savant, Gaurav. "Prediction of estuarine morphological evolution." Diss., Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-06202008-102016.
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4
au, 30365216@student murdoch edu, and Mee-Hua Wong. "Phosphite induces morphological and molecular changes in Phytophthora species." Murdoch University, 2006. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20070717.155119.
Full textAbstract:
The influence of the chemical phosphite on Phytophthora species was investigated by
studying the morphological and molecular changes induced by phosphite.
In vitro experiments were conducted to study the effects of phosphite on five isolates of
each of five species of Phytophthora grown in low phosphate defined medium. Sensitivity
to phosphite varied greatly among the five isolates of each species and resulted in a
significant interaction between isolate and phosphite effect. The EC50 values ranged from
less than 5 to 10 ìg/ml for P. cinnamomi, to 13 ìg/ml for P. nicotianae, to 27 ìg/ml for P.
citricola, to 24 ìg/ml for P. palmivora and to 49 ìg/ml for P. capsici.
Phosphite concentrations from 5 to 100 ìg/ml caused different degrees of morphological
changes. Mycelial growth of all species was significantly suppressed by phosphite at 5
ìg/ml while at 100 ìg/ml there was hyphal lysis. Swelling of hyphae with stunted sidebranches
and shrinking of cytoplasm from hyphal tips and hyphal walls were characteristic
changes observed. Phosphite also retarded the development and caused distortion and lysis
of chlamydospores, sporangia and zoospores. Zoosporogenesis was also adversely
affected.
Differential display reverse transcription-PCR was used to study changes in gene
expression in P. cinnamomi induced in response to phosphite stress. The differential
conditions were simulated by growth on a defined medium with and without phosphite
amendment. This technique resulted in the isolation of 34 putative differentially expressed
cDNA fragments which were cloned and sequenced. Nucleotide sequences of 26 of these
cDNA clones were generated. BLASTX analysis of these nucleotide sequences against the
NCBI database revealed that 18 exhibited homology to gene sequences encoding known
proteins involved in various biological processes. The remaining eight showed homology to
either hypothetical or unknown or unnamed proteins.
The expression level of four of these cDNA clones were further analysed by real-time
quantitative RT-PCR using SYBR Green 1 assay. Three candidate endogenous reference
genes namely, tubulin, cyclophilin and actin were evaluated to determine their expression
level under the influence of phosphite. None of these genes were significantly regulated by
phosphite. As tubulin had the highest expression among the three, it was chosen as the
endogenous reference gene. Amplification efficiencies between the reference gene and
each of the target genes were validated and found to be approximately equal or within 5%
of each other. The relative gene expression between the phosphite-treated and untreated
samples can thus be determined using the comparative CT (ÄÄCT) method. One of the
cDNA clones, CP6 which showed differential expression of three-fold was up-regulated.
The remaining three were constitutively expressed. CP6 which encodes 1564 nucleotides
showed sequence homology, at the amino acid level with proteophosphoglycans from
Leishmania major.
This study demonstrated the growth inhibition and morphological deformities caused by
phosphite in Phytophthora species. It also illustrated the use of a modified DDRT-PCR
method to study genes expressed in phosphite stress regulation. The application of real-time
quantitative RT-PCR with SYBR Green I assay facilitated the quantification of the
expression level of some of these genes.
5
Brismar, Harald. "Morphological and molecular changes in developing guinea pig osteoarthritis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-456-9/.
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6
Semianiv, I. O. "Morphological changes in hepatocytes in patients with pulmonary tuberculosis." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18225.
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7
Yusupova, A. F. "Morphological changes of myocardium in conditions of simulated osteoporosis." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/53918.
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Relevance. Various forms and stages of osteoporosis are characterized by changes in the concentration of Calcium in blood. Calcium is one of the foundational elements which influences myocardial contractile function. Aim. The aim of the study is to investigate pathological changes of myocardium in conditions of modelled osteoporosis.
8
Russell, Gregor. "Cognition and morphological brain changes in Charles Bonnet syndrome." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/cognition-and-morphological-brain-changes-in-charles-bonnet-syndrome(d3e47e4d-4030-42c0-a78a-24f1c8dd5ff6).html.
Full textAbstract:
Charles Bonnet syndrome (CBS) is defined as complex persistent visual hallucinations in the absence of mental disorder. It is associated with advanced age and poor vision. It is common, with prevalence estimates of up to 63% among older people with significant visual impairment. CBS would not be diagnosed in the presence of dementia, but its relationship to milder cognitive impairment is unclear. The few studies that have examined this are underpowered and provide contradictory results. There are 16 case reports of dementia emerging in people with a diagnosis of CBS. These cases raise the possibility of an association between impaired insight at diagnosis of CBS and the subsequent development of dementia. This thesis reports the findings of a prospective cohort study which describes changes in cognitive functioning over one year in patients with CBS and age-matched controls. Participants were recruited from low vision and glaucoma assessment clinics. A clinical assessment was carried out by an old age psychiatrist, and participants had a detailed assessment of visual functioning. This thesis also describes the findings of the first study to use voxel-based morphometry (VBM) to investigate changes in volume of grey and white matter in CBS. Participants were recruited from the same clinics as the cohort study, and underwent MRI scanning on a 1.5T scanner, to a protocol designed to produce 1mm3 voxels. Twelve participants with CBS and ten controls were followed up. Two people in the CBS group developed dementia, while none did in the control group. The CBS group showed a mean change in the score on the Addenbrooke’s cognitive examination (ACE-R) of -3.7 points, compared to a change of +1.4 in the control group. This difference was not statistically significant. The CBS participants performed worse on the verbal fluency item of the ACE-R, a difference which was statistically significant. The VBM analysis was conducted on 11 CBS participants and 11 controls. The CBS group showed an increase in grey matter volume in the right cerebellar hemisphere. This difference retained significance after family-wise error correction, non-stationary correction, and ANCOVA to control for the effects of possible confounders. As far as the author is aware, these are the most methodologically robust studies to date to have investigated cognition and morphological brain changes in CBS. The findings of the cohort study were inconclusive. However, the two cases of dementia in CBS patients add weight to the suspicion that this is a clinically important outcome in the condition, and the finding of abnormalities in frontal lobe testing in participants with CBS fits with a theoretical model of visual hallucination generation. Moreover, this type of research appears to be acceptable to a frail and visually disabled population, and studies powered to investigate this issue more fully would be feasible. The VBM findings report the presence of underlying structural brain abnormalities in CBS, in a region not usually associated with visual hallucinations. Possible links with Lewy body dementia, and implications for theories of visual hallucinations, are discussed.
9
Wong, Mee-Hua. "Phosphite induces morphological and molecular changes in Phytophthora species." Thesis, Wong, Mee-Hua (2006) Phosphite induces morphological and molecular changes in Phytophthora species. Masters by Research thesis, Murdoch University, 2006. https://researchrepository.murdoch.edu.au/id/eprint/413/.
Full textAbstract:
The influence of the chemical phosphite on Phytophthora species was investigated by studying the morphological and molecular changes induced by phosphite.
In vitro experiments were conducted to study the effects of phosphite on five isolates of each of five species of Phytophthora grown in low phosphate defined medium. Sensitivity to phosphite varied greatly among the five isolates of each species and resulted in a significant interaction between isolate and phosphite effect. The EC50 values ranged from less than 5 to 10 mcg/ml for P. cinnamomi, to 13 mcg/ml for P. nicotianae, to 27 mcg/ml for P. citricola, to 24 mcg/ml for P. palmivora and to 49 mcg/ml for P. capsici.
Phosphite concentrations from 5 to 100 mcg/ml caused different degrees of morphological changes. Mycelial growth of all species was significantly suppressed by phosphite at 5 mcg/ml while at 100 mcg/ml there was hyphal lysis. Swelling of hyphae with stunted sidebranches and shrinking of cytoplasm from hyphal tips and hyphal walls were characteristic changes observed. Phosphite also retarded the development and caused distortion and lysis of chlamydospores, sporangia and zoospores. Zoosporogenesis was also adversely affected.
Differential display reverse transcription-PCR was used to study changes in gene expression in P. cinnamomi induced in response to phosphite stress. The differential conditions were simulated by growth on a defined medium with and without phosphite amendment. This technique resulted in the isolation of 34 putative differentially expressed cDNA fragments which were cloned and sequenced. Nucleotide sequences of 26 of these cDNA clones were generated. BLASTX analysis of these nucleotide sequences against the NCBI database revealed that 18 exhibited homology to gene sequences encoding known proteins involved in various biological processes. The remaining eight showed homology to either hypothetical or unknown or unnamed proteins.
The expression level of four of these cDNA clones were further analysed by real-time quantitative RT-PCR using SYBR Green 1 assay. Three candidate endogenous reference genes namely, tubulin, cyclophilin and actin were evaluated to determine their expression level under the influence of phosphite. None of these genes were significantly regulated by phosphite. As tubulin had the highest expression among the three, it was chosen as the endogenous reference gene. Amplification efficiencies between the reference gene and each of the target genes were validated and found to be approximately equal or within 5% of each other. The relative gene expression between the phosphite-treated and untreated samples can thus be determined using the comparative CT ([Delta][Delta]CT) method. One of the cDNA clones, CP6 which showed differential expression of three-fold was up-regulated. The remaining three were constitutively expressed. CP6 which encodes 1564 nucleotides showed sequence homology, at the amino acid level with proteophosphoglycans from Leishmania major.
This study demonstrated the growth inhibition and morphological deformities caused by phosphite in Phytophthora species. It also illustrated the use of a modified DDRT-PCR method to study genes expressed in phosphite stress regulation. The application of real-time quantitative RT-PCR with SYBR Green I assay facilitated the quantification of the expression level of some of these genes.
10
Wong, Mee-Hua. "Phosphite induces morphological and molecular changes in Phytophthora species." Wong, Mee-Hua (2006) Phosphite induces morphological and molecular changes in Phytophthora species. Masters by Research thesis, Murdoch University, 2006. http://researchrepository.murdoch.edu.au/413/.
Full textAbstract:
The influence of the chemical phosphite on Phytophthora species was investigated by studying the morphological and molecular changes induced by phosphite.
In vitro experiments were conducted to study the effects of phosphite on five isolates of each of five species of Phytophthora grown in low phosphate defined medium. Sensitivity to phosphite varied greatly among the five isolates of each species and resulted in a significant interaction between isolate and phosphite effect. The EC50 values ranged from less than 5 to 10 mcg/ml for P. cinnamomi, to 13 mcg/ml for P. nicotianae, to 27 mcg/ml for P. citricola, to 24 mcg/ml for P. palmivora and to 49 mcg/ml for P. capsici.
Phosphite concentrations from 5 to 100 mcg/ml caused different degrees of morphological changes. Mycelial growth of all species was significantly suppressed by phosphite at 5 mcg/ml while at 100 mcg/ml there was hyphal lysis. Swelling of hyphae with stunted sidebranches and shrinking of cytoplasm from hyphal tips and hyphal walls were characteristic changes observed. Phosphite also retarded the development and caused distortion and lysis of chlamydospores, sporangia and zoospores. Zoosporogenesis was also adversely affected.
Differential display reverse transcription-PCR was used to study changes in gene expression in P. cinnamomi induced in response to phosphite stress. The differential conditions were simulated by growth on a defined medium with and without phosphite amendment. This technique resulted in the isolation of 34 putative differentially expressed cDNA fragments which were cloned and sequenced. Nucleotide sequences of 26 of these cDNA clones were generated. BLASTX analysis of these nucleotide sequences against the NCBI database revealed that 18 exhibited homology to gene sequences encoding known proteins involved in various biological processes. The remaining eight showed homology to either hypothetical or unknown or unnamed proteins.
The expression level of four of these cDNA clones were further analysed by real-time quantitative RT-PCR using SYBR Green 1 assay. Three candidate endogenous reference genes namely, tubulin, cyclophilin and actin were evaluated to determine their expression level under the influence of phosphite. None of these genes were significantly regulated by phosphite. As tubulin had the highest expression among the three, it was chosen as the endogenous reference gene. Amplification efficiencies between the reference gene and each of the target genes were validated and found to be approximately equal or within 5% of each other. The relative gene expression between the phosphite-treated and untreated samples can thus be determined using the comparative CT ([Delta][Delta]CT) method. One of the cDNA clones, CP6 which showed differential expression of three-fold was up-regulated. The remaining three were constitutively expressed. CP6 which encodes 1564 nucleotides showed sequence homology, at the amino acid level with proteophosphoglycans from Leishmania major.
This study demonstrated the growth inhibition and morphological deformities caused by phosphite in Phytophthora species. It also illustrated the use of a modified DDRT-PCR method to study genes expressed in phosphite stress regulation. The application of real-time quantitative RT-PCR with SYBR Green I assay facilitated the quantification of the expression level of some of these genes.
11
Atladottir, Audur. "Experimental investigation of wave-induced morphological changes of gravel beaches." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27665.
Full textAbstract:
Gravel beaches are widespread around the North-Atlantic Ocean shorelines and can also be found along the coastlines of New Zealand, Russia and the Pacific shore of USA. Over the past decades, researchers in coastal morphodynamics have placed their emphasis on studying sand beaches but gravel material is being used more frequently to nourish eroding sand beaches.
The present thesis aims to advance the understanding of the behaviour of gravel beaches under wave attack. A two-dimensional physical model was developed for gravel beach applications. Regular and irregular waves were considered as well as two different initial beach slopes.
An extensive analysis was performed on the time history of the waves, beach morphology, wave reflection and energy dissipation. Additional geotechnical analysis was also performed in order to identify the characteristics of the beach material. Wave height, wave period, wave duration and initial beach slope were all found to influence beach deformation and wave reflection pattern.
12
Siddig, Rasha Siddig Ahmed. "Diet dependent morphological changes of the rumen ephithelium in sheep /." Berlin : Köster, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016483818&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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13
Walla, Therese [Verfasser]. "Morphological changes and outcome in CMV anterior uveitis / Therese Walla." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042953/34.
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14
Blott, Simon James. "Morphological and sedimentological changes on artificially nourished beaches, Lincolnshire, U.K." Thesis, Royal Holloway, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396149.
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15
Sheppard, Amy L. "IN VIVO analysis of ocular morphological changes during phakic accommodation." Thesis, Aston University, 2010. http://publications.aston.ac.uk/12628/.
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The principal theme of this thesis is the in vivo examination of ocular morphological changes during phakic accommodation, with particular attention paid to the ciliary muscle and crystalline lens. The investigations detailed involved the application of high-resolution imaging techniques to facilitate the acquisition of new data to assist in the clarification of aspects of the accommodative system that were poorly understood. A clinical evaluation of the newly available Grand Seiko Auto Ref/ Keratometer WAM-5500 optometer was undertaken to assess its value in the field of accommodation research. The device was found to be accurate and repeatable compared to subjective refraction, and has the added advantage of allowing dynamic data collection at a frequency of around 5 Hz. All of the subsequent investigations applied the WAM-5500 for determination of refractive error and objective accommodative responses. Anterior segment optical coherence tomography (AS-OCT) based studies examined the morphology and contractile response of youthful and ageing ciliary muscle. Nasal versus temporal asymmetry was identified, with the temporal aspect being both thicker and demonstrating a greater contractile response. The ciliary muscle was longer in terms of both its anterior (r = 0.49, P <0.001) and overall length (r = 0.45, P = 0.02) characteristics, in myopes. The myopic ciliary muscle does not appear to be merely stretched during axial elongation, as no significant relationship between thickness and refractive error was identified. The main contractile responses observed were a thickening of the anterior region and a shortening of the muscle, particularly anteriorly. Similar patterns of response were observed in subjects aged up to 70 years, supporting a lensocentric theory of presbyopia development. Following the discovery of nasal/ temporal asymmetry in ciliary muscle morphology and response, an investigation was conducted to explore whether the regional variations in muscle contractility impacted on lens stability during accommodation. A bespoke programme was developed to analyse AS-OCT images and determine whether lens tilt and decentration varied between the relaxed and accommodated states. No significant accommodative difference in these parameters was identified, implying that any changes in lens stability with accommodation are very slight, as a possible consequence of vitreous support. Novel three-dimensional magnetic resonance imaging (MRI) and analysis techniques were used to investigate changes in lens morphology and ocular conformation during accommodation. An accommodative reduction in lens equatorial diameter provides further evidence to support the Helmholtzian mechanism of accommodation, whilst the observed increase in lens volume challenges the widespread assertion that this structure is incompressible due to its high water content. Wholeeye MRI indicated that the volume of the vitreous chamber remains constant during accommodation. No significant changes in ocular conformation were detected using MRI. The investigations detailed provide further insight into the mechanisms of accommodation and presbyopia, and represent a platform for future work in this field.
16
Raylyanu, S. I. "Morphological changes of tissues in patients with chronic inguinal hernias." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19681.
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Vinichenko, I. "Morphological changes in pancreas after induce diabetes in young rats." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/65516.
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Diabetes mellitus is chronic endocrine metabolic disease which is caused by the action of endogenous factors, with relative or absolute insufficiency of insulin, leading to disorders of metabolism. Diabetes mellitus induce by using alloxan which related to hyperglycemias' chemicals due to increase hepatic glucose.
18
Shinde, Suhas, Jedaidah Chilufya, Shivakumar Devaiah, Ruth Welti, and Aruna Kilaru. "Anandamide-Mediated Growth, Morphological and Cellular Changes in Physcomitrella Patens." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/4785.
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Chilufya, Jedaidah, S. Khurana, L. Vidali, and Aruna Kilaru. "Anandamide-Mediated Growth, Morphological And Cellular Changes In Physcomitrella Patens." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/4792.
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Sancho, García Amanda. "Beach inundation and morphological changes during storms using video monitoring techniques." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/113376.
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The predictability of beach inundation is mainly related to wave runup and most of the formulations that have been developed focus on the hydrodynamics, disregarding the morphological changes caused during storms. For these reasons, the aim of this thesis is to provide more insight into beach inundation processes at embayed and open beaches and to determine how morphological changes can interfere with these processes. To this end, video measurements of beach inundation and the characteristic morphological changes were carried out at two stretches of coast with different wave climates: the stretch comprising La Barceloneta, Somorrostro and Nova Icaria, which are three artificial, tideless embayed beaches located in Barcelona, Spain (NW Mediterranean); and Noordwijk beach, which is an open, microtidal multibarred beach located in Noordwijk, the Netherlands (North Sea). The effects of a submerged and a detached breakwaters on the morphological and hydrodynamic changes occurring at La Barceloneta during storms is examined in chapter 2. The shoreline response before and after the beach nourishment and the construction of the protective structures was compared using a ten-year video-recorded dataset and hydrodynamics modelled using the SMC model. As a result of the protection works, La Barceloneta was divided into two beaches separated by a salient. A new methodological approach to analyzing beach rotation which eliminates the morphological effect is presented. Results indicate that the beach rotation process has been modified caused by a change in the wave-induced current system from a single dominant alongshore current to one composed of two dominant alongshore currents with opposite directions. In chapter 3, beach inundation affecting the three embayed beaches of Barcelona during the 17 strongest storm events of the period 2001-2008 is analyzed using daily time-exposure images. The shoreline variability due to storms was split into beach planform and morphological features in order to determine its influence on beach inundation measurements. The characterization of the inundation depended on the orientation with respect to the wave direction approach and the morphological features. Beach planform changes are the foremost influence on the inundation of Barcelona beaches. The inundation at the multibarred beach of Noordwijk during the seven strongest storms in the period between 1998 and 2005 is estimated, also using video monitoring techniques in chapter 4. Additionally, the influence of subtidal sandbars on the inundation is analyzed using the XBeach model. To this end, six simulations were carried out using barred profiles measured at Noordwijk but differing in sandbar height and location, and one simulation using a synthetic barless profile. Inundation values ranged from 22 to 105 m, with considerable alongshore variation before the peak of each storm because of the presence of the intertidal bars. The mean inundation values along the beach are well estimated using a simple inundation parameter. The XBeach model shows that the inundation is only affected by the morphology close to the shoreline (i.e. by the intertidal bars or the inner bar if it is wide and closer to shoreline). The outer bar does not seem to influence Beach inundation prediction at Somorrostro beach is evaluated in chapter 5. To this end, inundation measurements using video observations are compared with estimations including the tidal variations and the wave runup formulation of Stockdon et. al (2006) introducing deep water and local wave measurements and computations. The inundation is overestimated if any of the wave heights in the formulation are used. Estimations improved if a local wave height is used, in particular for waves approaching the shore obliquely. Finally, the alongshore variability of the inundation is better captured if the wave runup is assumed proportional to the breaking wave heightBARCELONA07Las costas están expuestas a la erosión y la inundación producida por los temporales, los cuales son muy frecuentes y pueden producir grandes daños y pérdidas económicas. La inundación producida por los temporales es debida a la marea astronómica y meteorológica y al remonte del oleaje. La predicción de la inundación de la playa está principalmente relacionada con el remonte y la mayoría de las formulaciones propuestas se centran en parámetros hidrodinámicos sin tener en cuenta los cambios morfológicos causados durante los temporales. Por todo ello, el principal objetivo de esta tesis es proporcionar un mayor conocimiento de los procesos de inundación en playas encajadas y abiertas y determinar cómo los cambios morfológicos pueden interferir con estos procesos. Para ello, se han llevado a cabo medidas de la inundación y de los cambios morfológicos característicos utilizando imágenes de video en dos tramos de costa con climas de oleaje diferente: el tramo que comprende las playas de La Barceloneta, Somorrostro and Nova Icaria, las cuales son tres playas artificiales, encajadas y sin marea localizadas en Barcelona, España (NO Mediterráneo); y la playa de Noordwijk, la cual es una playa abierta, multibarrada y micromareal localizada en Noordwijk, Holanda (Mar del Norte). Los efectos de un dique sumergido y un dique exento en los cambios morfológicos e hidrodinámicos ocurridos en la playa de La Barceloneta durante temporales se examinan en el capítulo 2. La respuesta de la línea de orilla antes y después de la regeneración de la playa y de la construcción de las estructuras de protección se compara utilizando 10 años de video imágenes y la hidrodinámica modelada utilizando el Sistema de Modelado Costero (SMC). Como resultado de estas obras de protección, La Barceloneta quedó dividida en dos playas independientes separadas por un saliente. Una nueva metodología para analizar la rotación de la playa que elimina los cambios morfológicos es propuesta. Los resultados indican que la tendencia erosiva previamente observada en la zona noreste de la playa sigue estando presente en la actual playa noreste y está relacionada con el nuevo dique sumergido. Además, el proceso de rotación de la playa se ha modificado, produciéndose solamente en sentido contrario a las agujas del reloj en la playa noreste y en sentido horario en la playa suroeste. Este nuevo comportamiento es debido al cambio en el patrón de corrientes previamente formado por una corriente longitudinal dominante, a un sistema de corrientes compuesto por dos corrientes longitudinales en direcciones opuestas. En el capítulo 3, la inundación producida en las tres playas encajadas de Barcelona durante los 17 temporales más energéticos del periodo 2001-2008 es analizada utilizando imágenes diarias promediadas. La variabilidad de la línea de orilla debida a los temporales es discriminada en cambios en la forma en planta y morfologías (cúspides de playa, megacúspides, ondulaciones y saliente) para determinar su influencia en las medidas de inundación de la playa. La caracterización de la inundación dependió de la orientación respecto de la dirección de aproximación del oleaje y de las morfologías. Los cambios en la forma en planta de la playa son la máxima influencia en la inundación de las playas de Barcelona. Los cambios en la forma en planta hacia tierra y los cambios en el saliente suponen casi un 50% de la máxima inundación medida, mientras que las megacúspides y la ondulación suponen aproximadamente el 25%. El efecto de las cúspides de playa en la inundación es despreciable. Consecuentemente, la variación en la línea de orilla durante temporales influye significativamente los valores de inundación, especialmente en playas con pendientes fuertes. Pequeñas variaciones en la pendiente de la playa pueden sin embargo afectar sustancialmente la inundación en playas con pendientes suaves. La inundación de la playa multibarrada de Noordwijk durante los 7 temporales más fuertes ocurridos en el periodo comprendido entre 1998 y 2005 es también estimada utilizando medidas de video monitorización en el capítulo 4. Además, la influencia de las barras submareales en la inundación es analizada utilizando el modelo XBeach. Para ello, se realizaron siete simulaciones 1-D sin considerar los cambios morfológicos; seis simulaciones utilizando perfiles barrados medidos en la playa de Noordwijk pero que difieren en altura y localización de las barras, y una simulación utilizando un perfil ideal sin barras. Los valores de inundación oscilaron entre 22 y 105 m, con variaciones considerables a lo largo de la playa antes del pico del temporal debido a la presencia de barras intermareales. La inundación promedio a lo largo de la playa es estimada considerablemente bien utilizando un parámetro de inundación sencillo que incluye la pendiente intermareal y supramareal, la altura de ola y la longitud de onda en aguas profundas y la marea meteorológica. El modelo XBeach muestra que la inundación está solamente afectada por la morfología próxima a la línea de orilla, esto es, por las barras intermareales o por la barra interna si es ancha y próxima a la orilla. La barra externa no parece tener influencia en el comportamiento de la inundación. La predicción de la inundación en la playa de Somorrostro es evaluada en el capítulo 5. Para ello, medidas de la inundación utilizando observaciones de imágenes de video se comparan con estimaciones de la inundación incluyendo las variaciones de la marea y el fórmula del remonte de Stockdon et al. (2006), introduciendo medidas locales y en aguas profundas del oleaje así como oleaje modelado. Debido a que las observaciones corresponden a un remonte medio y las estimaciones usan el remonte excedido un 2% (R2%), la inundación es sobreestimada para cualquier altura de ola utilizada en la fórmula. Sin embargo, las estimaciones mejoran si una altura de ola medida a 10 m es utilizada en la fórmula en particular para oleajes con una aproximación oblicua a la línea de orilla. Finalmente, las diferencias entre las observaciones y las estimaciones varían a lo largo de la playa, siendo mayores en la zona de curvatura de la playa. La variabilidad de la inundación a lo largo de la playa es mejor caracterizada si el remonte se asume igual que la altura de ola en rotura.
21
Rutkowski, Paul, and Christian Albrecht May. "The peripheral and Central Humphrey visual field – morphological changes during aging." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230161.
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Background: To define age-related changes in the visual field by comparing "standard" central and unique peripheral visual field measurements in healthy volunteers.
Methods:
In a single center, retrospective, Cross-sectional, observational study, 20 volunteers with no retinal diseases or risk factors, ranging in age between 30 and 94 years (four age groups: 30’s, 50’s, 70’s, 90’s) were measured in one eye (preferentially the right one) using a Humphrey visual field 24–2 and 60–4.
Results:
While the central visual field remained relatively well preserved during aging showing only a mild reduction in sensitivity, a profound loss of the peripheral visual field was observed beginning in the fifth decade of life and decreasing continuously up to the 90ies.
Conclusions:
The peripheral visual field declined substantially from the 4th decade onward while the central visual field remained quite stable.
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Steans, Pippa Helen. "Morphological changes during the growth and etching of 111-V semiconductors." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325364.
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Приходько, Ольга Олексіївна, Ольга Алексеевна Приходько, Olha Oleksiivna Prykhodko, and M. Salifu. "Morphological changes in the spleen of a rat caused by dehydration." Thesis, Сумський державний університет, 2014. http://essuir.sumdu.edu.ua/handle/123456789/35796.
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The spleen of the rat is invariably inseparable with that of the human. The study investigates the various morphological changes that will occur in the spleen of the rat when it is subjected to dehydration for a variable period. The study was conducted and its objectives are stated below;
To understand the basic anatomy of the spleen of the rat and its relationship with that of human.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35796
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Scherbakoff, Natalia. "Rheological, interfacial and morphological changes produced by fillers in immiscible blends." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060353014.
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Davis, Colin M. "Imaging analysis of morphological changes to vertebrae in adolescent idiopathic scoliosis." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/105133/1/Colin_Davis_Thesis.pdf.
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This thesis employs imaging analysis using CT and MRI scans to comprehensively document the changing three-dimensional pedicle anatomy that occurs in the growing spine of adolescent idiopathic scoliosis patients and compare this to healthy control subjects. This study aims to not only provide information regarding the pathophysiology of adolescent idiopathic scoliosis but also to provide critical information to spinal surgeons operating on these spines to reduce the risk of serious complications.
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Leaman, Jason. "Morphological changes of native rat achilles tendons following augmented soft tissue mobilization." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1117857.
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Augmented Soft Tissue Mobilization, a massage therapy which uses a solid instrument rather than human fingers to treat musculoskeletal injuries, has been successful in treating tendinitis. Davidson et al. studied the functional and morphological affects of ASTM on collagenase induced Achilles tendinitis in Sprague-Dawley rats. Morphological observations showed a significant increase in the number and activation of fibroblasts in the ASTM treated Groups. The authors suggested that the physical force of ASTM may promote tendon healing via increased fibroblast recruitment. An important, but unexplained, question is how ASTM would affect the fibroblasts of native, noncollagenase injured, tendons. Studies have shown that mechanical forces can alter cellular functions. The purpose of this study was to examine the morphological changes in native Sprague-Dawley rat Achilles tendons after ASTM therapy using different application pressures.Three animal Groups were randomly established: A) control Group with no ASTM; B) light ASTM with 1 Newton of pressure; and C) heavy ASTM with 3 Newtons of pressure. Upon completion of the therapy, the Achilles tendons of each Group were examined with light and electron microscopy techniques to assess fibroblast number, tendon morphology, and the presence of type I and type III collagen. Fibroblast counts from each Group were compared using a two-way ANOVA, multiple regression, and curvilinear regression analysis. Morphological differences were shown between the three Groups, especially between the non force Group and the two force Groups. The ASTM Group treated with one Newton demonstrated the greatest mean fibroblast count (165.1+/-55.8&160.7+/-49.8). Electron microscopy revealed the presence of activated fibroblasts in the tendons of the two force Groups, ASTM Groups. Polarizing microscopy showed a dramatic increase in the amount of Type III collagen in the two force Groups compared to the non force Group.Ball State UniversityMuncie, IN 47306
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Frerichs, Dhana. "Computer graphics simulation of organic and inorganic optical and morphological appearance changes." Thesis, Bournemouth University, 2017. http://eprints.bournemouth.ac.uk/30016/.
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Organic bodies are subject to internal biological, chemical and physical processes as well as environmental interactions after death, which cause significant structural and optical changes. Simulating corpse decomposition and the environmental effects on its surface can help improve the realism of computer generated scenes and provide the impression of a living, dynamic environment. The aim of this doctorate thesis is to simulate post mortem processes of the human body and their visual effects on its appearance. The proposed method is divided into three processes; surface weathering due to environmental activities, livor mortis and natural mummification by desiccation. The decomposing body is modelled by a layered model consisting of a tetrahedral mesh representing the volume and a high resolution triangle surface mesh representing the skin. A particle-based surface weathering approach is employed to add environmental effects. The particles transport substances that are deposited on the object’s surface. A novel, biologically-inspired blood pooling simulation is used to recreate the physical processes of livor mortis and its visual effects on the corpse’s appearance. For the mummification, a physically-based approach is used to simulate the moisture diffusion process inside the object and the resulting de- formations of the volume and skin. In order to simulate the colouration changes associated with livor mortis and mummification, a chemically-based layered skin shader that considers time and spatially varying haemoglobin, oxygen and moisture contents is proposed. The suggested approach is able to model changes in the internal structure and the surface appearance of the body that resemble the post mortem processes livor mortis, natural mummification by desiccation and surface weathering. The surface weathering approach is able to add blemishes, such as rust and moss, to an object’s surface while avoiding inconsistencies in deposit sizes and dis- continuities on texture seams. The livor mortis approach is able to model the pink colouration changes caused by blood pooling, pressure induced blanching effects, fixation of hypostasis and the purple discolouration due to oxygen loss in blood. The mummification method is able to reproduce volume shrinkage effects caused by moisture loss, skin wrinkling and skin darkening that are comparable to real mummies.
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Nyale, Sammy Mwasaha. "Chemical, physical and morphological changes in weathered brine slurried coal fly ash." University of the Western Cape, 2011. http://hdl.handle.net/11394/5427.
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>Magister Scientiae - MScEnergy production from coal comes with an environmental cost because of the toxic waste produced during coal combustion such as coal ash and brine which are potential water and soil pollutants. Coal ash and brine contain toxic elements which can leach and contaminate soils and ground water if not properly disposed. This study investigated the mobility of species in coal fly ash co-disposed with brine at Sasol Secunda power station in order to establish if the ash dam could act as a salt sink. The ash was dumped as a slurry with 5:1 brine/ash ratio and the dam was in operation for 20 years. It was hypothesized that the disposed Secunda fly ash was capable of leaching toxic metal elements into the surrounding soils and ground water and therefore could not be used as a long term sustainable salt sink. Weathered fly ash samples were collected along a 51 m depth core at the Secunda ash dam by drilling and sampling the ash at 1.5 m depth intervals. A fresh fly ash sample was collected from the hoppers in the ash collection system at the power station. Characterization of both Secunda fresh ash and Secunda weathered ash core samples was done using X-ray diffraction (XRD) for mineralogy, X-ray fluorescence (XRF) for chemical composition and scanning electron microscopy (SEM) for morphology. Analysis of extracted pore water and moisture content determination of Secunda fresh ash and Secunda weathered ash core samples was done in order to evaluate the physico-chemical properties of the fly ash. The chemical partitioning and mobility of metal species in the ash dam was evaluated using the sequential extraction procedure. The XRD spectra revealed quartz, mullite and calcite as the dominant mineral phases in the weathered Secunda ash core samples while Secunda fresh ash contained quartz, mullite and lime. The major oxides identified by XRF analysis for both Secunda fresh ash and Secunda weathered ash include: SiO₂, Al₂O₃, CaO, Fe₂O₃, MgO, Na₂O, TiO₂ and K₂O. The minor oxides identified for both Secunda fresh ash and Secunda weathered ash were P₂O₅, SO₃ and MnO. The trace elements identified for both Secunda fresh ash and Secunda weathered ash were As, Ba, Ce, Co, Nb, Ni, Pb, Rb, Sr, V, Y, Zr and Th. However, U was detected in some of the Secunda weathered ash samples but not in Secunda fresh ash. Both Secunda fresh ash and Secunda weathered ash was classified as class F based on the sum of the oxides of silicon, aluminium and iron by mass and the CaO content as reported by XRF analysis, and further classified as sialic and ferrocalsialic type highlighting the significant levels of Si, Al, Ca and Fe in the fly ash based on XRF analysis. The XRF analysis further showed that brine codisposal on the ash may have been responsible for the slight enrichment of some species such as Na, SO₄²⁻, Mg, K and V in the disposed Secunda weathered fly ash. However, there was no significant accumulation of these species in the disposed fly ash despite continuous addition of an estimated 117.65 billion litres of brine over the 20 year period that the dam existed. Furthermore, Secunda ash dam showed an overall total salt capture capacity of only -0.01 weight %, a strong indication that the ash dam was incapable of holding salts and would release elements to the environment over time. The scanning electron microscopy (SEM) analysis revealed spherical particles with smooth outer surfaces for Secunda fresh ash while Secunda ash core samples consisted of agglomerated, irregular particles appearing to be encrusted, etched and corroded showing that weathering and leaching had occurred in the ash dam. A decrease in pH, electrical conductivity (EC) and total dissolved solids (TDS) was observed in Secunda ash core samples compared to Secunda fresh ash. While Secunda fresh ash (n = 3) had a pH of 12.38 ± 0.15, EC value of 4.98 ± 0.03 mS/cm and TDS value of 2.68 ± 0.03 g/L, the pH of Secunda ash core (n = 35) was 10.04 ± 0.50, the EC value was 1.08 ± 0.14 mS/cm and the TDS value was 0.64 ± 0.08 g/L. The lower pH in the ash dam created an environment conducive to the release of species through leaching, while the lower EC and TDS in the ash dam implied the loss of ionic species from the ash which resulted from leaching. The moisture content (MC) analysis indicated that Secunda ash dam was very damp with an average MC of 54.2 ± 12.66 % for Secunda ash core creating favourable conditions for leaching of species in the ash dam while Secunda fresh ash had MC of 1.8 ± 0.11 %. The bottom of Secunda ash dam appeared water logged which could cause slumping of the dam. The sequential extraction procedure revealed that the major and trace elements contained in both Secunda fresh fly ash and Secunda weathered fly ash could leach upon exposure to different environmental conditions. The elements showed partitioning between five geochemical phases i.e. water soluble fraction, exchangeable fraction, carbonate fraction, Fe & Mn fraction and residual fraction. The labile phases consisted of the water soluble fraction, exchangeable fraction and carbonate fraction. The % leached out in the labile phases was expressed as a fraction of each element‟s total content e.g. Si (6.15 %) meant that 6.15 % of the total amount of Si in the ash was released in the labile phases. Na was the most labile among the major elements in the ash dam while Si and Al which form the major aluminosilicate ash matrix also showed significant lability. The % leached out in the labile phases for these major elements was as follows: for Secunda fresh ash: Si (6.15 %), Al (7.84 %), Na (11.31 %); for weathered Secunda ash core samples (n = 35): Si (7.53 %), Al (8.12 %), Na (11.63 %). This study showed that the fly ash generated at Sasol Secunda power station could not be used as a long term sustainable salt sink. The wet disposal method used at Sasol Secunda power station poses a high risk of groundwater contamination due to the high liquid to solid ratio used to transport the ash for disposal, which may lead to rapid dissolution of all the soluble components in the fly ash. The large volumes of brine that pass through Secunda ash dam in the wet ash handling system present a greater environmental concern than the dry ash handling system which involves small amounts of brine entering the ash dump.
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Ogbodo, Amobi, and A. Yusupova. "Morphological changes of thyroid gland in conditions of extracellular dehydration of organism." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/44928.
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A thyroid gland has a high ability to morphofunctional reformation under the impact of exo- and endogenous factors. Presently, the most studied are: the influence on the thyroid of ionizing radiation, temperature rate, physical activity, traumatic stress, tobacco smoke, various hormones, xenobiotics, drugs. However, in the modern scientific literature, the morphological changes in conditions of water-salt metabolism dysfunction is highlighted insufficiently.
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Poole, Catherine Ann. "Ontogenesis of Peptide Transport and Morphological Changes in the Ovine Gastrointestinal Tract." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/35458.
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Nutrient absorption is important in all stages of life. As the diet of an animal changes from birth on, morphological and biochemical adaptation can be anticipated in order to accommodate changing demands. The main focus of the present study was to examine the relationship between age and diet on the potential for peptide transport via PepT1 in the gastrointestinal tract of lambs and to relate changes of peptide transport capability to morphological changes. A 2x4 factorial arrangement of treatments was used with 32 crossbred lambs. Four blocks were created based upon gender, birth type (single or twin), birth weight, and birth date. Lambs were randomly allotted at birth to receive or not to receive a creep diet. All lambs were allowed to nurse. Sampling times of 2, 4, 6, or 8 wk were randomly allotted to lambs. Samples for RNA extraction and histological evaluation were taken from the dorsal rumen, ventral rumen, omasum, duodenum, jejunum, and ileum. Villi were about 7% shorter (P < 0.09) in lambs receiving creep feed. Papillary height and width increased linearly (P < 0.001 and P < 0.0001, respectively) with age. Total and keratinized epithelial cells in the stomach decreased (P < 0.03 and P < 0.004, respectively) with age and were fewer (P < 0.0002 and P < 0.0001, respectively) in lambs receiving creep feed. Creep feeding appears to have slightly altered the mucosal structure of the small intestine and it was advantageous in that it stimulated papillary growth and thus predisposed the rumen for the introduction of feed into the diet. A 2.8 kb oPepT1 mRNA was present in all tissues studied by 2 wk, and age did not significantly influence the abundance of oPepT1 mRNA in the small intestine or stomach. In the small intestine, abundance of oPepT1 mRNA was greatest (P < 0.0007) in the jejunum. In the stomach, abundance of oPepT1 mRNA was greatest (P < 0.01) in the dorsal rumen. In the stomach, particularly in the rumen, a greater abundance of oPepT1 mRNA was observed in lambs not receiving the creep diet. It seems likely that a stimulus for development is coming from the non-luminal direction, possibly blood-borne, and may be involved in the ontogenesis of oPepT1. Peptide transport appears to be a physiologically important process in the young lamb and the rumen appears to be involved in the transport of peptides, particularly in nursing lambs.Master of Science
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Green, Kathryn Margaret. "Morphological changes during normal and pertubed metamorphosis of the ascidian herdmania curvata /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16468.pdf.
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Myers, Kimberly S. "Rat tendon morphological changes due to augmented soft tissue mobilization at various pressures." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1041917.
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Augmented soft tissue mobilization therapy (ASTM) is a newly developed massage technique. ASTM is applied with the aid of specifically designed, solid instruments and has been successfully used in the treatment of chronic tendinitis patients. In a study on collage nase -injure d rat Achilles tendons treated with ASTM, Davidson et. al (1997) reported gait improvement as well as fibroblasts proliferation and suggested ASTM may augment healing by the recruitment of fibroblast. The present study examined the morphological response of enzyme-induced rat Achilles tendons to 3 different ASTM pressure application: 1 newton; 2 newtons and 3 newtons. Collagenase-injured tendons exhibited disrupted and randomly arranged collagen fibers. Treatment applications were performed for 4 days for a total of 4 treatments. Morphological differences were demonstrated between groups in proportion to the ASTM treatment pressure application. The ASTM group treated with 3 newtons demonstrated the greatest mean fibroblast count (370.3 +/- 51.6). Further, electron microscopy revealed the presence of activated fibroblasts in the tendons of the 3 newtons, ASTM group. However, immunochemical staining comparisons of Type I and III collagen, fibroblast growth factor receptor, and insulin-like growth factor between groups were not remarkable.Department of Physiology and Health Science
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Janse, van Rensburg Lindie. "A morphological analysis of weevils from sub-Antarctic Prince Edward Islands an assessment of ecological influences /." Pretoria : Db [s.n.], 2005. http://upetd.up.ac.za/thesis/available/etd-08242006-125130.
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Chu, Chun-hung. "Surface morphological changes and marginal adaptation of glass cermet cement restorations in primary molars." Click to view the E-thesis via HKUTO, 1992. http://sunzi.lib.hku.hk/HKUTO/record/B38628223.
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Mathur, Aastha [Verfasser], and Francois [Akademischer Betreuer] Nedelec. "Role of cytoskeleton in morphological changes of blood platelets / Aastha Mathur ; Betreuer: Francois Nedelec." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177688425/34.
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Chu, Chun-hung, and 朱振雄. "Surface morphological changes and marginal adaptation of glass cermet cement restorations in primary molars." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B38628223.
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Dikal, M. V. "Morphological changes in the cortex of the kidneys under the development of aseptic fever." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19537.
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Marsh, Donald. "Changes in Psychological, Morphological, and Performance Characteristics in Preparation for a National Weightlifting Competition." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etd/3642.
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The primary aim of this study was to examine the time course of change in muscle morphology and vertical jump performance in weightlifters preparing for a national competition. The secondary aim of this study is to examine how perceived recovery and stress state corresponds with alterations in training load leading up to competition. Eleven Olympic Training Site weightlifters completed a 4-week peaking phase for a national competition. Body mass, stress and recovery psychometric measures, and unloaded/loaded (20kg) squat jump height (SJH) were measured weekly and at the competition site. Vastus lateralis cross-sectional area (CSA), muscle thickness (MT) and pennation angle (PA) ultrasound measurements were taken prior to and following the training protocol. In competition, 6 athletes set a personal best in snatch, clean and jerk and/or total. These results suggest that improvements in the loaded SJ and psychometric measures correspond to successful competition performance in some weightlifters. Notably, most weightlifters appeared to be peaked within 3 days of competition.
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Sugimoto, Shinichi. "Morphological changes induced by extracellular matrix are correlated with maturation of rat small hapatocytes." Kyoto University, 2003. http://hdl.handle.net/2433/148690.
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Geekiyanage, Nadeeshani Maheshika. "Numerical investigation of recoverability of morphological and deformability changes of stored red blood cells." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/137216/1/Nadeeshani%20Maheshika_Geekiyanage_Thesis.pdf.
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This thesis developed a numerical model based on the coarse-graining method to accurately and efficiently represent the changes in shape and deformability of ageing red blood cells during in vitro storage. The quality of the red blood cells declines during storage affecting the effectiveness of transfusion treatments, and this study discusses the recoverability of these changes in shape and deformability for achieving potential improvements to current storage practices for better transfusion outcomes. Further, this study is extensible to investigate the shape and deformability characteristics of healthy and diseased red blood cells for better diagnostics and treatments.↲
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McDonald, Ann Laster. "Morphological and physiological changes in laying hens in various stages of non-feed withdrawal molt." Diss., Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-11072008-124615.
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Tran, Amy V. "Do BHA and BHT Induce Morphological Changes and DNA Double-Strand Breaks in Schizosaccharomyces pombe?" Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/152.
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Butylated Hydroxyanisole, BHA, and Butylated Hydroxytoluene, BHT, are commonly used as preservatives for our food as well as additives in many products such as cosmetics, petroleum, and medicine. Although their use has been approved by the Food and Drug Administration (FDA), there have been controversies and debates on whether these phenol derivatives or antioxidants are safe to use. Their accumulative toxicology and side effects need to be thoroughly investigated as we continue to consume them on a daily basis. Data obtained by genomic analysis in Tang lab suggested the involvement of DNA damage checkpoint/repair pathways in the response network to these phenol stress factors. The aims of this thesis are to examine the morphological changes and potential DNA damage induced by exposing cells to BHA and BHT using fission yeast Schizosaccharomyces pombe as a model organism. Fluorescence microscopy was used to assess DNA double-strain breaks (DSBs) by monitoring the nuclear foci formation of Rad22, a DNA repair protein, in the presence of BHA and BHT. Changes in cell morphology were also studied under microscope. Preliminary data showed that cells treated with BHA and BHT exhibited morphological changes. In addition, for the first time in S. pombe cells, Rad22 foci in the nucleus of BHA and BHT treated cells were observed. Further investigation is needed to optimal the experimental condition to continue the study. These results will not only help us to better understand the effect of these phenol derivatives in the cells, but can also establish an experimental system for future studies on the interaction of the cells with stress factors and therapeutic drugs for human-related diseases such as cancer.
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Kelly, Patricia J. "Morphological changes of collagenase induced tendinitis of achilles rat tendons utilizing augmented soft tissue mobilization." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1129629.
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Augmented Soft Tissue Mobilization (ASTM) is a new noninvasive technique utilized to treat chronic musculoskeletal injuries. The purpose of this study was to trace the morphological events in collagenase injured rat Achilles tendons during ASTM treatment and to observe passive occurrence of post treatment remodeling in tendons. Twelve groups of rats were divided into the following categories, A) control, B) sham surgery, C) ASTM only, D) ASTM/sham , E) tendinitis, F) ASTM/tendinitis 1 week, G) ASTM/tendinits 2 weeks H) ASTM/tendinits 3 weeks I) ASTM/tendinits 4 weeks, J) Post ASTM 5 weeks, K) Post ASTM 10 weeks, L) Post ASTM 15 weeks. One week after the last designated treatment, the Achilles tendons were harvested and then prepared for light microscopy, electron microscopy, and bifringence polarizing microscopy. An increase in fibroblast activation and proliferation was noted with the tendinitis, ASTM/tendinitis, and post groups. Ossification occurred in the core of the Achilles tendon in all of the ASTM groups. The presence of inflammatory cells was observed in the tendons and longitudinal remodeling of the collagen fibers did not occur.Department of Biology
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Yalamanchili, Anurag. "Insights into the morphological changes undergone by the anode in the lithium sulphur battery system." Thesis, Uppsala universitet, Strukturkemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-236378.
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In this thesis, the morphological changes of the anode surface in lithium sulphur cell, during early cycling, were simulated using symmetrical lithium electrode cells with dissolved polysulphides (PS) in the electrolyte. Electron microscopy (SEM) was used as the principal investigation technique to study and record the morphological changes. The resulting images from the SEM were analysed and discussed. The initial surface structure of the lithium anode largely influenced the ensuing morphological changes taking place through lithium dissolution (pits) and lithium deposition (dendrites) during discharge and charge respectively. The rate of lithium dissolution and deposition was found to be linearly proportional to the current density applied to the cell and the effect of cycling on the anode was proportional to the total charge of the cell in general in agreement with the expected reaction. The effect of self-discharge on the anode was also studied using photoelectron spectroscopy (XPS) in tandem with SEM. The results indicated that self-discharge, occurring in the form of corrosion of the anode SEI by PS reduction, was influenced by the altered morphology of the cell after cycling. The findings presented in this project can be understood as a preliminary description for the morphological changes in the anode and their influence in the performance of lithium sulphur battery, which can be further investigated by more advanced methods.Joint collaboration project between Scania CV AB and Uppsala University.
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Davis, Ahriea. "M1 macrophages promote morphological changes and NF-KAPPA B nuclear translocation in prostate epithelial cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2016. http://digitalcommons.auctr.edu/dissertations/3190.
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In this study, we sought to define an underlying molecular mechanism of how inflammation induces cancer initiation. Cancer-associated inflammation is marked by the presence of inflammatory cells and mediators including cytokines, chemokines, and reactive oxygen species. There is a growing body of evidence establishing the link between chronic inflammation and cancer. Twenty percent of cancers have been linked to chronic infections. For instance, bacterial and viral infections induce inflammation which is a known risk factor for cancer. During inflammation, Ml macrophages' production of pro-inflammatory cytokines and reactive oxygen species (ROS) drives their function as anti-microbial. Likewise, the transcription factor nuclear factor kappa B (NF-KB) is known to induce a variety of stimulators, including ROS, to contribute to the inflammatory process. Therefore, we sought to explore the relationship between Ml macrophages and NF-KB, suggesting that Ml macrophage mediates cancer initiation via a NF-KB-dependent pathway, which collectively contributes to a metastatic phenotype.
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MacKenzie, Stenton. "FTM faces : morphological and morphometric changes in facial pattern in female-to-male transsexual people." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/917ef15b-75b2-4e63-aa30-6bc040102493.
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This research documents for the first time changes in the facial appearance that occur in female-to-male transsexuals (FTMs) with exogenous testosterone therapy and oophorectomy. Method: 25 FTM transsexual faces were assessed morphologically using comparative facial analysis, and morphometrically using 2D pre-transition photographs and 3D post-transition facial models (FASTSCAN Scorpion laser scanner & Geomagic Freeform - a 3D modeling software with Phantom haptic feedback device). Subjects: The average age of the post-transition subjects was 39 years; all subjects had been taking testosterone for a minimum of 3 years (range 3.3 � 21.1 years), with an average duration of 8.6 years. Objectives: To describe the qualitative and quantitative transformation from a female-appearing to a male-appearing face, and to identify predictable patterns of change due to testosterone treatment. Results: 24% of subjects were classified as male-appearing pre-transition, and 96% post-transition; 96% had beard shadow/facial hair and 52% demonstrated male pattern balding. The majority of subjects (44%) became wider in the face overall, and facial width increases were the most frequently recorded change. 18 subjects demonstrated a narrower nasal width; 55.6% of those by between 7 - 17% of their original dimensions. Conclusions: Testosterone virilises natal female adult faces. One new consistent pattern of change was shown to be predictable: the nose will narrow at the alae. It is hypothesised that this is a result of facial fat re-deposition.
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Sun, Xiao-Ming. "Mechanism of cell death : early morphological changes and DNA degradation of apoptosis in rat thymocytes." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34241.
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Apoptosis is an active process of gene-directed cellular self-destruction. It serves a biological meaningful and homeostatic function in diverse circumstances, including embryonic development, physiological involution or pathological atrophy of adult organs, normal tissue turnover, immune cell ontogeny and immune killing. A new flow cytometric method using Hoechst 33342/ propidium iodide staining has been established in this study. The basis of this method is the change of apoptotic thymocytes both in cell size and membrane permeability. This method has been used to study glucocorticoids or DNA topoisomerase inhibitor-induced apoptosis in immature rat thymocytes both in vitro (dexamethasone, etoposide, m-AMSA and camptothecin) and in vivo (etoposide). During establishment of the flow cytometric method, it was found that induction of apoptosis by dexamethasone was not inhibited by zinc as assessed by flow cytometry. Further studies indicated that apoptotic thymocytes induced by dexamethasone in the presence of zinc showed distinct morphology and other cellular changes characteristic of apoptosis but no DNA laddering. Thus, internucleosomal cleavage of DNA was, for the first time, dissociated experimentally from early nuclear morphological changes, as well as other cytoplasmic changes. Identification of a transitional preapoptotic population of thymocytes further confirmed this observation. In this population of cells, early nuclear morphological changes and other cytoplasmic changes were observed in the absence of DNA laddering. By using field inversion gel electrophoresis, it was found that formation of kilobase pair fragments of DNA preceded internucleosomal cleavage of DNA. Formation of large fragments of DNA was particularly visualised when thymocytes were treated with dexamethasone in the presence of zinc, due to an inhibitory effect of zinc on the internucleosomal cleavage of DNA. These large fragments of DNA were also present in the transitional preapoptotic population of thymocytes in the absence of oligonucleosomal fragments. Further studies with isolated thymocyte nuclei showed that formation of these large fragments of DNA was a Mg2+-dependent process that can be facilitated by Ca2+. The nature of these large fragments, the mechanism involved in their formation and their relevance to apoptosis reqire further investigation.
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Knut, R. P., and R. I. Sydorchuk. "Morphological changes of hernia sac and hernia-surrounding tissues in elderly patients suffering inguinal hernias." Thesis, БДМУ, 2017. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/16905.
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Сікора, Володимир Віталійович, Владимир Витальевич Сикора, Volodymyr Vitaliiovych Sikora, Анатолій Миколайович Романюк, Анатолий Николаевич Романюк, Anatolii Mykolaiovych Romaniuk, Юлія Миколаївна Линдіна, et al. "Morphological changes in collagen fibers of urinary bladder caused by influence of heavy metal salts." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55021.
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Introduction. Today the environmental pollution with heavy metal salts (HMS) is an important issue, because of their toxic effects and prevalence in different layers of the biosphere. Once getting in the body, they circulate with blood and partly accumulated in the organs causing harmful effects on tissues and cells. Urinary bladder(UB) refers to bodies that are subject to double impact of heavy metals. Thus, urine together with its components (including HMS)accumulate and definite time contact with mucous membranes of UB and also the pollutants get into the organhematogenously.
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DOAN, VAN BINH. "IMPACTS OF UPSTREAM DAM DEVELOPMENT ON FLOW, SEDIMENT AND MORPHOLOGICAL CHANGES IN VIETNAMESE MEKONG DELTA." Kyoto University, 2019. http://hdl.handle.net/2433/244533.
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