Journal articles: 'Mortaline'

1

Wadhwa, Renu, Sunil C. Kaul, and Youji Mitsui. "Cellular Mortality to Immortalization: Mortalin." Cell Structure and Function 19, no. 1 (1994): 1–10. http://dx.doi.org/10.1247/csf.19.1.

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2

Ferrarelli, Leslie K. "Inducing mortality by targeting mortalin." Science 367, no. 6483 (March 12, 2020): 1207.17–1209. http://dx.doi.org/10.1126/science.367.6483.1207-q.

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3

Fioritti, Angelo, Daniela Lipparini, and Vittorio Melega. "Mortality of long-term psychiatric inpatients. Retrospective study on a cohort of long-term patients in the psychiatric hospital of Bologna, Italy." Epidemiologia e Psichiatria Sociale 3, no. 2 (August 1994): 107–14. http://dx.doi.org/10.1017/s1121189x00003559.

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RiassuntoScopo - Il presente studio è stato condotto per determinare il rischio di mortalità nei pazienti psichiatrici lungo-degenti. Setting - Ex ospedale psichiatrico provinciale «F. Roncati» di Bologna. Disegno - Studio di coorte retrospettivo con un follow-up di dieci anni in cui si è calcolato il tasso di mortalità complessivo e disaggregato per diagnosi psichiatrica, durata del ricovero e condizione «ricoverato al termine del follow-up/dimesso», dei 264 pazienti degenti presso l'istituto l'1.1.1981. Misure utilizzate - I tassi di mortalità sono stati calcolati e successivamente confrontati utilizzando il Rapporto Standardizzato di Mortalità (Standardized Mortality Ratio - SMR). La standardizzazione per sesso e classi di età è avvenuta prendendo come riferimento la mortalita della popolazione residente a Bologna nel decennio 1981-1991. La presenza nella coorte dei singoli soggetti è stata misurata in anni-persona. Risultati - La condizione di de- gente comporta un eccesso di mortalità di 2.89 per gli uomini (IC 95%: 2.12-3.86) e di 2.38 (IC: 1.66-3.31) per le donne. Si è registrato inoltre un forte eccesso di mortalità per la classe di eta dai 15 ai 44 anni sia per gli uomini (18.33; IC: 9.14-32.81) che per le donne (60; IC: 21.91-130.6) e nei soggetti con diagnosi di caratteropatia/alcolismo (uomini, 11.25; IC: 5.13-21.36; donne, 5; IC: 1.35-12.8). Si è registrata infine una diminuzione dell'eccesso di mortalita al crescere della durata del ricovero e della eta dei pazienti. Conclusioni - Lo studio conferma l'esistenza di un forte rischio di mortalita associato alia condizione di paziente psichiatrico istituzionalizzato, concentrato soprattutto nelle classi d'età piu giovani, nei primi anni di ricovero e nei soggetti con diagnosi di caratteropatia/alcolismo.

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Kumazaki, T. "Expression of endothelin, fibronectin, and mortalin as aging and mortality markers." Experimental Gerontology 32, no. 1-2 (April 1997): 95–103. http://dx.doi.org/10.1016/s0531-5565(96)00080-0.

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HÜSEYİN, Serhat, Volkan YÜKSEL, Ümit HALICI, Gönül SAĞIROĞLU, Selami GÜRKAN, Özcan GÜR, Ahmet OKYAY, Suat CANBAZ, Turan EGE, and Hasan SUNAR. "Mortality After Elective Vascular Surgery: Reality We Dont Talk About." Damar Cerrahi Dergisi 23, no. 1 (2014): 19–23. http://dx.doi.org/10.9739/uvcd.2014-39526.

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6

Bostan, Cem. "Long-Term Mortality of Nonvalvular Atrial Fibrillation." Kosuyolu Heart Journal 18, no. 3 (December 7, 2015): 135–38. http://dx.doi.org/10.5578/khj.10086.

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7

Timotić, Branovoje, Mirjana Timotić, and Biljana Anđelski-Radičević. "Morbidity and, mortality of the parents." Zdravstvena zastita 39, no. 6 (2010): 67–71. http://dx.doi.org/10.5937/zz1002067t.

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COŞKUN, Ramazan, Kürşat GÜNDOĞAN, Elif ATAĞ, İsmail Hakkı AKBUDAK, Ahmet ÖZTÜRK, Muhammet GÜVEN, and Murat SUNGUR. "Predictors of Mortality in Critically Ill Patients with Poisoning: A Single Center Experience." Turkiye Klinikleri Journal of Medical Sciences 33, no. 5 (2013): 1274–82. http://dx.doi.org/10.5336/medsci.2012-33098.

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Niksarlioglu, Elif Yelda, Begüm Ergan Arsava, Ahmet Ugur Demir, Arzu Topeli Iskit, and Lutfi Coplu. "Risk Factors Associated with Mortality of COPD Patients Hospitalised for Exacerbation." Turkish Thoracic Journal/Türk Toraks Dergisi 14, no. 4 (October 19, 2013): 134–40. http://dx.doi.org/10.5152/ttd.2013.26.

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10

Nath, Jyan Dip. "Maternal mortality reduction in Assam." New Indian Journal of OBGYN 5, no. 1 (July 2018): 3–7. http://dx.doi.org/10.21276/obgyn.2018.5.1.2.

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11

Bonnet, Fabrice, Christine Burty, Charlotte Lewden, Dominique Costagliola, Thierry May, Vincent Bouteloup, Eric Rosenthal, et al. "Changes in Cancer Mortality among HIV‐Infected Patients: The Mortalité 2005 Survey." Clinical Infectious Diseases 48, no. 5 (March 2009): 633–39. http://dx.doi.org/10.1086/596766.

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12

Currie, Janet, Hannes Schwandt, and Josselin Thuilliez. "Pauvreté, Egalité, Mortalité: mortality (in)equality in France and the United States." Journal of Population Economics 33, no. 1 (June 24, 2019): 197–231. http://dx.doi.org/10.1007/s00148-019-00736-7.

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13

GÖKÇİMEN, Mecit, Emrah UĞUZ, Murat ÇİÇEK, Mete HIDIROĞLU, and Erol ŞENER. "Expected and Observed Mortality in Patients Undergoing Coronary Artery Bypass Surgery." Turkiye Klinikleri Journal of Medical Sciences 35, no. 3 (2015): 191–200. http://dx.doi.org/10.5336/medsci.2015-46294.

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14

GÖZEL, M. Gökhan, Ayşe ERBAY, Hürrem BODUR, Selim Sırrı EREN, and Neriman BALABAN. "Risk Factors for Mortality in Patients with Nosocomial Gram-Negative Bacteremia." Turkiye Klinikleri Journal of Medical Sciences 32, no. 6 (2012): 1641–47. http://dx.doi.org/10.5336/medsci.2011-27342.

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15

VISHWAKARMA, Gajendra K., Atanu BHATTACHARJEE, and Sharvari SHUKLA. "COVID-19 Mortality Prediction: An Algorithm by Bayesian Autoregressive Model." Turkiye Klinikleri Journal of Biostatistics 13, no. 2 (2021): 178–84. http://dx.doi.org/10.5336/biostatic.2020-80264.

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16

Holmquist, Iva, and Vanda Bostik. "PREGNANCY RELATED MATERNAL MORTALITY - CONTEMPORARY PERSPECTIVES." Military Medical Science Letters 88, no. 1 (March 8, 2019): 19–25. http://dx.doi.org/10.31482/mmsl.2018.033.

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17

Jutur, Srinivasa, and Krishna Kumar Naik T. "Mortality in Swine Flu: Descriptive Study." Asian Journal of Medical Research 8, no. 1 (March 2019): ME14—ME16. http://dx.doi.org/10.21276/ajmr.2019.8.1.me5.

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18

N.A., Kiryanov, Terehov V.Z., Chernov A.N., and Bochkarev A.N. "КЛИНИКО-АНАТОМИЧЕСКИЙ АНАЛИЗ МАТЕРИНСКОЙ СМЕРТНОСТИ." Bulletin "Biomedicine and sociology" 4, no. 2 (June 30, 2019): 3–9. http://dx.doi.org/10.26787/nydha-2618-8783-2019-4-2-3-9.

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19

Ghali, Abdullah. "Paclitaxel Mortality in Peripheral Artery Disease." Journal of Thoracic Disease and Cardiothoracic Surgery 2, no. 1 (April 28, 2021): 01–03. http://dx.doi.org/10.31579/2693-2156/019.

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Peripheral artery disease is a matter of global concern that affects 200 million people and is associated with decreased arterial perfusion in the extremities. The most plausible pathomechanism involves the formation of atheromas which subsequently cause occlusive atherosclerosis that impinge blood supply. Atheroma formation involves endothelial dysfunction with an accumulation of LDL (Low-density lipoprotein) that subsequently become oxidized and consumed by macrophages to form foam cells. The foam cells will release factors such as MMPs (Matrix metalloproteinases) and PDGF (platelet derived growth factor) that induce the proliferation and migration of smooth muscle cells, forming atheroma. Furthermore, endothelial cell damage can cause a loss of protective mechanisms, such as a reduction in the release of protective vasodilatory prostaglandins and Nitric Oxide. Atherosclerosis formation also decreases oxygen diffusion to the arterial media, resulting in atrophy in the vessel wall and ischemia. Additionally, chronic transmural inflammation cyclically releases increased MMPs and elastases that expand the arterial wall while degrading the protective collagen.

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20

KARADAYI, Kürşat, Mustafa TURAN, Şule KARADAYI, Hakan ALAGÖZLÜ, Saadettin KILIÇKAP, Abdullah BÜYÜKÇELİK, Cihat ŞARKIŞ, et al. "Cytoreductive Surgery Followed by Hyperthermic Intraperitoneal Chemotherapy: Morbidity and Mortality Analysis of Our Patients." Turkiye Klinikleri Journal of Medical Sciences 32, no. 1 (2012): 162–70. http://dx.doi.org/10.5336/medsci.2011-23538.

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21

ARSLAN, Zehra İpek, Ersan ÖZBUDAK, Neşe TÜRKYILMAZ, Sevim CESUR, Volkan ALPARSLAN, Ali Fuat MİRHANOĞULLARI, Zehra Nur BAYKARA, Kamil TOKER, and Mine SOLAK. "Evaluation of the Use of Colistin on Nephrotoxicity and Mortality in the Intensive Care Unit." Turkiye Klinikleri Journal of Anesthesiology Reanimation 13, no. 1 (2015): 21–24. http://dx.doi.org/10.5336/anesthe.2014-42738.

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22

PATMANO, Gülçin, Tuğba BİNGÖL, Mehmet TERCAN, and Ahmet KAYA. "The Effect of Serum Lactate and Lactate Clearence on Mortality in Cardiac Surgery Patients." Turkiye Klinikleri Cardiovascular Sciences 31, no. 3 (2019): 155–61. http://dx.doi.org/10.5336/cardiosci.2019-70462.

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23

Tarladaçalışır, Taner. "Factors affecting mortality in traumatic diaphragmatic ruptures." Turkish Journal of Thoracic and Cardiovascular Surgery 22, no. 1 (January 21, 2014): 118–25. http://dx.doi.org/10.5606/tgkdc.dergisi.2014.8700.

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24

Singh, Mahatab, S. S. Rathore, and Prameshwar . "Dysnatremia and Mortality in Surgical ICU Patients." New Indian Journal of Surgery 7, no. 3 (2016): 307–9. http://dx.doi.org/10.21088/nijs.0976.4747.7316.17.

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25

Micheloud, Juan, Leandro Olmos, Juan Garcia, Guillermo Mattioli, and Francisco Uzal. "Perinatal mortality in cattle associated with goitre." Brazilian Journal of Veterinary Pathology 12, no. 2 (July 29, 2019): 48–52. http://dx.doi.org/10.24070/bjvp.1983-0246.v12i2p48-52.

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26

Gorbunov, L. V. "COMPUTER MODELING OF EMBRYONIC MORTALITY AT CRIOCONSERVATION." Biotechnologia Acta 9, no. 4 (August 2016): 67–76. http://dx.doi.org/10.15407/biotech9.04.067.

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27

Berková, Marie, and Zdeněk Berka. "Falls: a significant cause of morbidity and mortality in elderly people." Vnitřní lékařství 64, no. 11 (November 1, 2018): 1076–83. http://dx.doi.org/10.36290/vnl.2018.154.

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28

Politi, Pierluigi, Cristina Montomoli, and Cesare Fratti. "Mortalità di una coorte di pazienti ricoverati in un Servizio Psichiatrico di Diagnosi e Cura (SPDC)." Epidemiologia e Psichiatria Sociale 2, no. 3 (December 1993): 199–204. http://dx.doi.org/10.1017/s1121189x00007028.

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RiassuntoScopo e Setting - Nel lavoro vengono presentati i risultati di uno studio di mortalità relativo ai pazienti ricoverati presso il Servizio Psichiatrico di Diagnosi è Cura di Pavia nel periodo 1.1.1986-31.12.1991. Principali misure utilizzate - La mortalita della coorte è stata stimata utilizzando il rapporto standardizzato di mortalità. Il numero di morti osservato per sesso, età e causa specifica è stato confrontato con il numero di morti attese utilizzando come popolazione di riferimento quella dello stesso bacino di utenza del Servizio (USSL di Pavia), specifica per sesso ed eta. Risultati - La mortalità della coorte in studio e risultata circa tre volte quella della popolazione generale. L'eccesso di mortalita si verifica sia per quanto riguarda le cause di morte naturale, sia per quelle di morte violenta. In particolare, si verifica un eccesso di mortalità in entrambi i sessi per quanto riguarda le cause legate alle malattie del sistema circolatorio, ai disturbi psichici e ai traumatismi ed avvelenamenti.

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29

BALCAN, Baran, Şehnaz OLGUN, Türkay AKBAŞ, Emel ERYÜKSEL, and Sait KARAKURT. "Level of adrenomedullin in cases with adrenal defficiency and its relation to mortality in patients with sepsis." Tuberkuloz ve Toraks 64, no. 3 (September 30, 2016): 191–97. http://dx.doi.org/10.5578/tt.10568.

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30

Şen, Onur, and Okan Yıldız. "Relation Between Cerebral Perfusion Changes and Mortality Scores During Cardiopulmonary Bypass at Adult Cardiac Surgery." Kosuyolu Heart Journal 22, no. 2 (August 1, 2019): 79–84. http://dx.doi.org/10.5578/khj.68121.

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31

Aygün, Fatih, and Mehmet Özülkü. "The Effect of Pump on Early Postoperative Mortality and Cerebrovascular Accident in Coronary Bypass Surgery Patients." Kosuyolu Heart Journal 21, no. 1 (April 18, 2018): 9–15. http://dx.doi.org/10.5578/khj.54094.

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32

Eggerickx, Thierry, Jean-Paul Sanderson, and Christophe Vandeschrick. "Mortality in Belgium from nineteenth century to today." Quetelet Journal 8, no. 2 (May 25, 2020): 7–59. http://dx.doi.org/10.14428/rqj2020.08.02.01.

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Résumé Cet article dresse une synthèse de l’évolution de la mortalité en Belgique du 19ème siècle à nos jours en mettant l’accent sur les inégalités socio-démographiques et spatiales. Il se base sur une revue de la littérature et exploite les données de la Human Mortality Database (HMD) pour les analyses consacrées à l’évolution de la mortalité selon l’âge et le sexe depuis le début du 19ème siècle. L’appariement des données du Registre national, des recensements de la population et des bulletins de décès de l’état-civil est mobilisé pour les analyses plus récentes (1991-2015). En Belgique, la durée moyenne de vie dépasse aujourd’hui 80 ans, soit deux fois plus qu’il y a 170 ans. Mais, comme dans d’autres pays occidentaux, des inégalités subsistent et parfois même se renforcent. Ainsi, les inégalités entre groupes sociaux face à la mort sont importantes et elles se sont accentuées depuis le début des années 1990, au moins. Ces différences sociales s’observent pour toutes les causes de décès et à tous les âges, chez les femmes comme chez les hommes. Les disparités spatiales de mortalité, à l’échelle des régions, des arrondissements et des milieux de résidence se sont également accrues depuis au moins un quart de siècle. De plus, à même groupe social, les disparités spatiales de mortalité persistent. Cela signifie que des facteurs environnementaux, culturels, comportementaux agissent de la même manière sur la mortalité pour chacun des groupes sociaux. Abstract This article offers an overview of shifts in mortality in Belgium from the nineteenth century to the present, particularly in terms of sociodemographic and spatial disparities. It analyzes these shifts in mortality according to age and sex since the early nineteenth century, drawing from a review of the literature and using data from the Human Mortality Database (HMD). For the more recent analyses (1991-2015), data from the National Register, population censuses and official death records were matched up. In Belgium, the average life expectancy is now 80 years, twice as long as 170 years ago. As in other Western countries, however, disparities persist and sometimes even widen. There are thus major inequalities between social groups in regards to death, and these have been worsening since at least the early 1990s. These inequalities are apparent for each cause of death and ages at death, for women and for men. Spatial inequalities in mortality by region, district and residential area have also widened over at least the past quarter century. Even within similar social groups there are spatial disparities in mortality, indicating that environmental, cultural and behavioural factors affect mortality in the same way for each social group.

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33

Aldama Negrete, Arnaldo Fabián, Dora Montiel-Jarolín, and Raúl Real. "Mortalidad en pacientes con dengue en la epidemia 2012-2013." DEL NACIONAL 7, no. 1 (June 1, 2015): 17–23. http://dx.doi.org/10.18004/rdn2015.0007.01.017-023.

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34

Milind, Dr Chakane, and Dr Kshirsagar Vinayak. "Necrotising Fasciitis :- Determinants of Mortality and Management Strategy." Indian Journal of Applied Research 2, no. 2 (October 1, 2011): 127–29. http://dx.doi.org/10.15373/2249555x/nov2012/48.

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35

Thengal, Dhuldev, Preeti Umate, and Mangala Shinde. "Determinants of Perinatal Mortality: A Hospital Based Study." Indian Journal of Obstetrics and Gynecology 5, no. 4 (2017): 490–95. http://dx.doi.org/10.21088/ijog.2321.1636.5417.8.

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36

Agarwal, Dr Dipti, Dr Abnish Kumar, Dr Nirmal Chandra Prajapati, and Dr saroj Singh. "Mortality in HIV Exposed Infants and It’s Determinants." Global Journal For Research Analysis 3, no. 5 (June 15, 2012): 105–6. http://dx.doi.org/10.15373/22778160/may2014/39.

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37

Merchán, Xavier, Belén Salamea, Marcelo Ochoa, and Fray Martínez. "Niveles de Lactato Sérico y Mortalidad en Pacientes Críticos." Revista Médica del Hospital José Carrasco Arteaga 6, no. 2 (September 15, 2014): 121–24. http://dx.doi.org/10.14410/2014.6.2.001.

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38

Kusumaadhi, Zaki Mita, Nur Farhanah, and Muchlis Achsan Udji Sofro. "Risk Factors for Mortality among HIV/AIDS Patients." Diponegoro International Medical Journal 2, no. 1 (March 10, 2021): 20–19. http://dx.doi.org/10.14710/dimj.v2i1.9667.

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Background: Morbidity and mortality of HIV/AIDS infections is still high and as a global health problem particularly in Low-Middle Income Countries (LMICs). Indonesia ranks third in Asia Pacific in increasing HIV infection. A Study on risk factors for mortality in HIV/AIDS patients in Dr. Kariadi General Hospital has never been conducted. This study analyzed the risk factors for mortality among HIV/AIDS patients.Methods: Case control study, data from medical records of inpatients and outpatients in Dr. Kariadi General Hospital from January 2015 to December 2017.Results: Study subject: Two hundred and ten HIV/AIDS patients, were included; 105 (56.75%) as cases and 105 (9.65%) control patients. The significant risk factors for mortality were as follow: male sex (p = 0.030); age ≥ 45 years (p = 0.035); non compliance to treatment (p = 0,000); WHO clinical stage III and IV (p = 0,000); co-infection of pulmonary tuberculosis (p = 0,000); CD4 cell count < 200 cells/mm3 (p = 0,000); eGFR < 60 mL/minute/1.72 m2 (p = 0.001) and Haemoglobin level < 10 g/dL (p = 0.008). The non-significant risk factors for mortality were as follow: level of education (p = 0.650); Hepatitis B co-infection (p = 0.153) and Hepatitis C co-infection (p = 0.506). The most important risk factors for mortality in this study in were non compliance to treatment (p = 0.003; OR = 3.285) and CD4 count < 200 cells/mm3 (p = 0.014; OR = 5.480).Conclusion: In this study, the risk factors for mortality in HIV/AIDS patients were male sex; age ≥ 45 years; non compliance to treatment; WHO clinical stage III and IV; co-infection of pulmonary tuberculosis, CD4 count < 200 cells/mm3; eGFR < 60 mL/minute/1.72 m2 and Hb level < 10 g/dL. The most important risk factors for mortality were non compliance to treatment and CD4 count < 200 cells / mm3.

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39

Rodrigues, Helena. "Impacto da Pandemia COVID-19 na Mortalidade em Serviço de Urgência." Medicina Interna 28, no. 3 (September 21, 2021): 257–63. http://dx.doi.org/10.24950/o/135/21/3/2021.

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Resumo: Introdução: Dados oficiais revelam que a mortalidade por todas as causas, em Portugal, em 2020 é superior à de 2019. O receio dos doentes de contágio por SARS-CoV-2 condicionou o protelar de avaliações médicas por opção ou imposição e o recurso aos Serviços de Urgência (SU) não foi exceção. O objetivo foi comparar as características demográficas, clínicas e analíticas dos doentes falecidos num SU dedicado à COVID-19, com igual período do ano pregresso. Material e Métodos: Estudo retrospetivo, no qual foram analisadas as notas de alta dos doentes que faleceram durante a permanência no SU entre os dias 18 de março e 22 de junho de 2019 e 2020. A análise estatística foi realizada com recurso ao programa IBM SPSS. Resultados: Durante o período analisado faleceram no SU 33 doentes no ano de 2019 e 99 doentes em 2020, o que equivale a uma taxa de mortalidade de 0,34% e 1,89%, respetivamente. Destaca-se que, em 2020, apenas 4,04% (n = 4) dos óbitos eram de doentes com zaragatoas SARS- -CoV-2 positivas ainda que todos os falecidos apresentassem infeções respiratórias graves. Houve uma diferença estatisticamente significativa no que concerne ao tempo de permanência no SU (p < 0,01), alectuamento (p = 0,04), demência (p = 0,03) e presença de insuficiência respiratória à admissão (p = 0,001). Não se verificaram diferenças no que diz respeito aos dados demográficos, maioria das comorbilidades e parâmetros analíticos. Conclusão: Em relação a 2019, os óbitos verificados em 2020 no SU ocorreram em doentes mais vulneráveis e com doença mais grave. Foi a procura mais tardia dos cuidados hospitalares, particularmente na agudização de doenças crónicas, que condicionou, de forma irreversível, este desfecho. O número de mortes passível de ser atribuído à COVID-19 é ínfimo, merecendo reflexão e readaptação de boas práticas que assegurem que os doentes sejam admitidos nos SU dentro das janelas temporais preconizadas e de acordo com as patologias suspeitas

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40

Cernigliaro, Achille, Addario Sebastiano Pollina, Gabriella Dardanoni, and Salvatore Scondotto. "L'esperienza della Sicilia nella costruzione e nell'uso di un indice sintetico di posizione socioeconomica per la stima della salute nella popolazione." SALUTE E SOCIETÀ, no. 1 (March 2009): 151–61. http://dx.doi.org/10.3280/ses2009-001013.

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- A regional socioeconomic index by municipality was build for the fist time. From last census (2001) was considerated education, employment, family, house condition ad immigration. Socioeconomic index was used to describe mortality in general people, highlighting that the social and economic disadvantage is a mortality predictor factor, different in both gender. Moreover it was used to adjust the estimates of mortality and morbidity in residents near the risk areas of Sicily. Key words: socioeconomic position, deprivation, mortality, risk area, petrochemical, epidemiology, Sicily. Parole chiave: posizione socioeconomica, deprivazione, mortalitÀ, area a rischio, petrolchimico, epidemiologia, Sicilia.

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41

Ando, Koji, Eiji Oki, Zhao Yan, Hiroyuki Kitao, Hiroshi Saeki, Takefumi Ohga, Yoshihiro Kakeji, Shunichi Tsujitani, Shunji Kohnoe, and Yoshihiko Maehara. "Significance of mortalin expression in gastric cancer with normal p53." Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 25. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.25.

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25 Background: Gastric cancer still has the highest morbidity rate and the second highest mortality rate. As chemotherapy confers only a minimal survival advantage, the prognosis of patients with advanced or recurrent gastric cancer remains poor. Studying the mechanisms and underlying molecules that drives gastric cancer malignant, could contribute to finding a remedy for gastric cancer. Mortalin is a heat non-inducible member of the heat shock protein 70 family. Mortalin binds to p53 and prevents p53 from entering the nucleus, as well as cell stress. To understand the significance of mortalin in gastric cancer, we investigated the expression of mortalin and p53. Methods: The expression of mortalin and p53 were examined by immunohistochemical staining of 182 clinical samples of gastric cancer. Results: Mortalin-positive and aberrant-p53-positive samples were found in 75.2% and 62.6% of cases, respectively. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases compared with mortalin-negative tumors (p < 0.01, p < 0.05, respectively). Mortalin-positive tumors had worse prognosis compared with mortalin-negative tumors (p = 0.035). Moreover, in tumors with normal p53 expression, mortalin-positive tumors had especially worse prognosis compared with mortalin-negative tumors (p = 0.013). With multivariate analysis, mortalin expression appeared to be an independent prognostic factor in gastric cancer with expression of normal p53 (p = 0.0174). Conclusions: Mortalin has a great impact on gastric cancer with normal p53. Therefore, mortalin is a target molecule for treatment of gastric cancer, as well as a promising prognostic factor, especially in tumors with normal p53.

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TOSUN TAŞAR, Pınar, Ömer KARAŞAHİN, Özge TİMUR, and Can SEVİNÇ. "Factors Associated with Mortality in Patients with Decubitus Ulcers Treated with Negative Pressure Wound Therapy." Flora the Journal of Infectious Diseases and Clinical Microbiology 24, no. 4 (December 2019): 377–83. http://dx.doi.org/10.5578/flora.68955.

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Mert, Kadir Uğur, Gurbet Özge Mert, and Muhammet Dural. "The Association Between Health Related Quality of Life and Five Year Mortality in Patients with ST-Elevated Myocardial Infarction." Kosuyolu Heart Journal 21, no. 1 (April 18, 2018): 26–31. http://dx.doi.org/10.5578/khj.57474.

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Ayöz, Sümeyye, Serhat Erol, Melahat Kul, Aslıhan Gürün Kaya, Ayşegül Gürsoy Çoruh, İsmail Savaş, Ömür Aydın, and Akın Kaya. "Using RV/LV ratio and cardiac biomarkers to define the risk of mortality from pulmonary embolism." Tuberk Toraks 69, no. 3 (September 22, 2021): 297–306. http://dx.doi.org/10.5578/tt.20219701.

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Vuk Pisk, Sandra, Igor Filipcic, Anamarija Bogovic, Zeljko Milovac, Ivana Todoric Laidlaw, and Sandra Caratan. "Malignant Diseases and Mental Disorders - Prevalence, Mortality, Therapeutic Challenge." Socijalna psihijatrija 45, no. 3 (September 12, 2017): 187–201. http://dx.doi.org/10.24869/spsih.2017.187.

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Stejskal, David, Bořek Lačňák, Pavlína Solichová, Libor Jedelský, František Všianský, Božena Hausnerová, and Michal Karpíšek. "Serum cystatin C as a long-term predictor of overall mortality." Cor et Vasa 48, no. 10 (October 1, 2006): 340–44. http://dx.doi.org/10.33678/cor.2006.111.

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Núñez Medina, Gerardo, Jorge Alberto López Arévalo, and César Raúl Pérez Marcial. "Mortalidad infantil y pobreza en los municipios de Chiapas." Revista Espacio I+D Innovación más Desarrollo 4, no. 9 (October 23, 2015): 35–61. http://dx.doi.org/10.31644/imasd.9.2015.a02.

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Kolo, Mustapha Adam, Muhammad Chutiyami, and Isyaku Ibrahim. "Trends Of Maternal Mortality In Damaturu, Yobe State, Nigeria." International Journal of Trend in Scientific Research and Development Volume-1, Issue-4 (June 30, 2017): 272–77. http://dx.doi.org/10.31142/ijtsrd122.

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Rajkumar, R. Vinodh. "RESISTING MORBIDITY AND MORTALITY (RMM): AN EQUITABLE PUBLIC HEALTH." International Journal of Physiotherapy and Research 8, no. 6 (December 11, 2020): 3693–705. http://dx.doi.org/10.16965/ijpr.2020.177.

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Abstract:

Every citizen deserves a lengthy, healthy and successful life. Survival competence and successful ageing basically require (i) ability to counteract gravitational force through adequate muscle strength, flexibility and postural control (ii) healthy nutrition (iii) optimal respiratory efficiency at rest and during physical activity (iv) mental health and (v) supportive family. Lifespan of people is basically under the control of both individual and community participation. The burden for the individual after acquiring either communicable or non-communicable diseases is always unique, based on numerous variables like age, gender, socioeconomic status, occupation, lifestyle, severity of the disease, co-morbidities and access to legitimate health services. If the burden of the morbidity is not alleviated effectively, various crippling effects interweave and lead to irreversible loss of structures and functions, eventually deteriorating or destroying the competence to sustain an occupation or the level of independence. Mishaps, calamities and wars are also capable of exerting immediate effect to cause irreparable damages in the body (burns, spinal cord injuries, head injuries, fractures) forcing the sufferer to endure a troublesome life. Though harms to the body are unpredictable events, the extent at which every individual and the community as a whole are prepared with skills and technology to encounter them, controls the outcomes. Some disease states demand prolonged or lifelong health care that relies on affordability and family structure. On the other hand, completely costless health services are unrealistic and unsustainable to private sectors or private practitioners in the medical field, excluding sporadic exceptions where the health care is rendered on humanitarian basis. To certain extent, volunteers could provide different types of support using limited resources (few examples are walking aids, medicine supply, water supply, food supply, housing, blood donations, medical camps) to save or sustain life. But very often, many diseases require extensive interdisciplinary approach where multiple specialties are involved, so the total cost of the medical procedures (diagnosis and treatment) get elevated, due to which the deprived will be forced to limit or avoid or procrastinate treatments facilitating chances for the disease to mature incurably. The rehabilitation of patients is explicitly complicated but prevention of diseases looks less complicated if the public health model accentuates its focus on exercise, nutrition and health education to powerfully resist morbidities and premature mortalities through integrated efforts of health care professionals and all other overlapping domains. Based on substantial literature support, this article proposes a framework ‘SHARE’ to encourage necessary refinements to flourish the civilization as scrupulous as possible. It is also need of the hour for professionals of various disciplines to examine how their expertise could support this framework. KEY WORDS: Public Health, Life Expectancy, Salutogenesis, Mortality, Morbidity, Exercise, Nutrition, Epidemiology, Spiritual Intelligence, Population ageing.

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Vera, Francisco, Mario Solorzano, Gina Ochoa, Sandra García Bustos, and Solange Cevallos. "Tablas de mortalidad de Ecuador continental mediante un análisis de supervivencia." Papeles de Población 24, no. 97 (July 31, 2018): 63–83. http://dx.doi.org/10.22185/24487147.2018.97.25.

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Journal articles on the topic 'Mortaline'

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