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1
Xue, Rui-De. "A NEW LABORATORY COLONIZATION OF AEDES AEGYPTI AFTER REEMERGENCE AND UNSUCCESSFUL ERADICATION IN ST. AUGUSTINE, FLORIDA." Journal of the Florida Mosquito Control Association 67, no. 1 (January 14, 2021): 73–75. http://dx.doi.org/10.32473/jfmca.v67i1.127639.
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After unsuccessful eradication attempts against Aedes aegypti (L.) following a sudden re-emergence in St. Augustine, Florida in early 2016; a new locally acquired colony strain of Ae. aegypti was established at the Anastasia Mosquito Control District (AMCD) in June 2017. Aedes aegypti adults were maintained in cages at the AMCD insectary. Larval and adult mosquitoes were collected from downtown St. Augustine, Florida. Female mosquitoes at 5-7 days old were fed upon the exposed forearm of human volunteers in the 1 st and 2 nd generations. Mating was observed in a large cage and confirmed with eggs deposited on wet filter paper in ovicups. Over 90% egg hatch was observed in the laboratory. The new colony strain of Ae. aegypti has been cataloged at the USDA, Center for Medical, Agricultural, and Veterinary Entomology facility in Gainesville, FL and is being used to further research and control this species across North Florida.
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GUNATHILAKA, NAYANA. "Annotated checklist and review of the mosquito species (Diptera: Culicidae) in Sri Lanka." Journal of Insect Biodiversity 7, no. 3 (October 3, 2018): 38–50. http://dx.doi.org/10.12976/jib/2018.07.3.1.
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Mosquito borne diseases remains as an importance source of morbidity and mortality in Sri Lanka. To better control vectors which transmit the diseases, updated list of the species present in the county is imperative. It is also vital in documenting the diversity of the family Culicidae. Original records were collected from a literature review to compile a list of the species recorded in Sri Lanka. This work illustrates the updated list of mosquito species in Sri Lanka and their current taxonomic status based on previous studies from 1901 to date. A total of 159 species belonging to 19 genera including sibling species, have been included in the revised mosquito checklist in Sri Lanka. The present work includes 13 species, two genera (Lutzia, Verrallina) and 9 subgenera in subfamily Culicinae, tribe Aedini of genus Aedes (Bruceharrisonius, Collessius, Danielsia, Dendroskusea, Downsiomyia, Fredwardsius, Hulecoeteomyia, Neomelaniconion, Phagomyia) in to the checklist which were not included in the previous mosquito checklist published nearly 26 years ago. However, further work is essential to refine this list and to explore the abundance of new species within the country. Improved morphological and molecular identification methods will sanction the refinement of the mosquito catalog in years to come.
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Urban, S. E., and G. L. Wycoff. "Densifying the Optical Reference Frame: The Tycho-2 Catalog of 2.5 Million Stars." International Astronomical Union Colloquium 180 (March 2000): 75–79. http://dx.doi.org/10.1017/s0252921100000130.
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AbstractSince the establishment of the Hipparcos Catalog as the defining source of the optical reference frame, densification beyond its ≈ 120,000 stars has been made possible by the utilization of the Tycho-1 Catalog. The ACT, combining the old Astrographic Catalog (AC) data with the Tycho-1 positions, is the best known example of this. The Tycho-2 consortium, led by E. Høg, has performed new reductions on the Tycho data. This not only has increased the astrometric and photometric accuracies of the original 1 million Tycho-1 stars, but also has added an additional 1.5 million stars. The U.S. Naval Observatory led the effort to compute the proper motions of these 2.5 million stars. They are based not only on the AC data but also include over 140 other ground-based catalogs, all directly reduced to the Hipparcos system. The result of these efforts is the Tycho-2 Catalog, available since February 2000. Positions, proper motions, and BT and VT magnitudes are given for 2.5 million stars. The catalog is 99% complete to V=11.0, and 90% complete to V=11.5. Positional accuracies at the mean epochs vary from < 10 mas for stars V < 9 to just under 100 mas for V > 12. Proper motion accuracies are estimated to be 1.3 mas/year to 3.0 mas/year for the same magnitude ranges. Photometric accuracies range from 0.02 magnitudes for the brightest stars to 0.25 magnitudes for the faintest.
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Ivezić, Ž., D. G. Monet, N. Bond, M. Jurić, B. Sesar, J. A. Munn, R. H. Lupton, et al. "Astrometry with digital sky surveys: from SDSS to LSST." Proceedings of the International Astronomical Union 3, S248 (October 2007): 537–43. http://dx.doi.org/10.1017/s1743921308020103.
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AbstractMajor advances in our understanding of the Universe have historically come from dramatic improvements in our ability to accurately measure astronomical quantities. The astrometric observations obtained by modern digital sky surveys are enabling unprecedentedly massive and robust studies of the kinematics of the Milky Way. For example, the astrometric data from the Sloan Digital Sky Survey (SDSS), together with half a century old astrometry from the Palomar Observatory Sky Survey (POSS), have enabled the construction of a catalog that includes absolute proper motions as accurate as 3 mas/year for about 20 million stars brighter than V=20, and for 80,000 spectroscopically confirmed quasars which provide exquisite error assessment. We discuss here several ongoing studies of Milky Way kinematics based on this catalog. The upcoming next-generation surveys will maintain this revolutionary progress. For example, we show using realistic simulations that the Large Synoptic Survey Telescope (LSST) will measure proper motions accurate to 1 mas/year to a limit 4 magnitude fainter than possible with SDSS and POSS catalogs, or with the Gaia survey. LSST will also obtain geometric parallaxes with accuracy similar to Gaia's at its faint end (0.3 mas at V=20), and extend them to V=24 with an accuracy of 3 mas. We discuss the impact that these LSST measurements will have on studies of the Milky Way kinematics, and potential synergies with the Gaia survey.
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ZACK, RICHARD S., AUBREY MOORE, and ROSS H. MILLER. "First record of a pygmy backswimmer (Hemiptera: Heteroptera: Pleidae) from Micronesia." Zootaxa 1617, no. 1 (October 17, 2007): 67–68. http://dx.doi.org/10.11646/zootaxa.1617.1.4.
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Pygmy backswimmers, pleids, can be common in aquatic habitats with stagnant or slow-moving water that is rich in vegetation. They are small bugs, usually less than 3.5 mm in length and confine themselves to the vegetation in which they hide and where they prey on mosquito larvae and other small arthropods (Schuh and Slater 1995). The family is represented by 37 species in three genera: Plea, confined to the Old World; Neoplea confined to the New World; and Paraplea, the largest and most widely distributed genus (Schuh and Slater 1995).
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Girelli, Giacomo, Micol Bolzonella, and Andrea Cimatti. "Massive and old quiescent galaxies at high redshift." Astronomy & Astrophysics 632 (December 2019): A80. http://dx.doi.org/10.1051/0004-6361/201834547.
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Aims. Questions of how massive quiescent galaxies rapidly assembled and how abundant they are at high redshift are increasingly important in the study of galaxy formation. Looking at these systems can shed light on the processes of galaxy mass assembly and quenching of the star formation at early epochs. In order to address these questions, we aim to identify and characterize massive quiescent galaxies from z ∼ 2.5 out to the highest redshifts at which these systems can be found. The final purpose is to compare the results with the predictions of state-of-the-art semi-analytical models of galaxy formation and evolution. Methods. We defined observer-frame color–color diagrams to optimally select quiescent galaxies at z > 2.5 and applied them to the COSMOS2015 catalog. We refined the spectral energy distribution (SED) fitting analysis for the selected candidates to confirm their quiescent nature, then derived their number density, mass density, and stellar mass functions. Finally, we compared the results with previous observations and some current semi-analytic models. Results. We selected candidates for quiescent galaxies in the redshift range 2.5 ≲ z ≲ 4.5 from the COSMOS2015 catalog by means of two color–color diagrams. The additional SED fitting analysis allowed us to select 128 galaxies, consistent with being massive (log(M*/M⊙)≥10.6), old (ages ≳0.5 Gyr), and quiescent (log(sSFR [yr−1]) ≤ −10.5) objects at high redshift (2.5 < z < 4.5). Their number and mass densities are in fair agreement with previous observations and, if confirmed, show a discrepancy with current semi-analytical models of galaxy formation and evolution, that underpredict the number of massive quiescent systems up to a factor of ∼12 at 2.5 ≤ z < 3.0 and ∼10 at z ∼ 4.0. The evolution of the stellar mass functions (SMFs) of these systems is similar to previous estimates and indicates a disagreement with models, particularly with regard to the shape of the SMF. Conclusions. The present results add further evidence to the possibility that massive and quiescent galaxies can exist out to at least z ∼ 4. If future spectroscopic observations carried out with, for example, the James Webb Space Telecope (JWST), confirm the substantial presence of such a population, further work on modeling the stellar mass assembly, as well as supermassive black hole accretion and feedback processes at early cosmic epochs, is needed to understand how these systems formed, evolved, and quenched their star formation.
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Velasco, Henry, Henry Laniado, Mauricio Toro, Alexandra Catano-López, Víctor Leiva, and Yuhlong Lio. "Modeling the Risk of Infectious Diseases Transmitted by Aedes aegypti Using Survival and Aging Statistical Analysis with a Case Study in Colombia." Mathematics 9, no. 13 (June 24, 2021): 1488. http://dx.doi.org/10.3390/math9131488.
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Many infectious diseases are deadly to humans. The Aedes aegypi mosquito is the principal vector of infectious diseases that include chikungunya, dengue, yellow fever, and zika. Some factors such as survival time and aging are vital in its development and capacity to transmit the pathogens, which in turn are affected by environmental factors such as temperature. In this paper, we consider aging as the biological wear and tear presented in some mosquito populations over time, whereas survival is considered as the maximum time that a mosquito lives. We propose statistical methods that are commonly used in engineering for reliability analysis to compare transmission riskiness among different mosquitoes. We conducted a case study in three Colombian cities: Bello, Riohacha, and Villavicencio. In this study, we detected that the Aedes aegypi female mosquitoes in Bello live longer than in Riohacha and Villavicencio, and the females in Riohacha live longer than those in Villavicencio. Regarding aging, the females from Riohacha age slower than in Villavicencio and the latter age slower than in Bello. Mosquito populations that age slower are considered young and the other ones are old. In addition, we detected that the females from Bello in the temperature range of 27 ∘C–28 ∘C age slower than those in Bello at higher temperatures. In general, a young female has a higher risk of transmitting a disease to humans than an old female, regardless of its survival time. These findings have not been previously reported in studies of this type of infectious diseases and contributed to new knowledge in biomedicine.
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Marti-Soler, Helena, Mara Máquina, Mercy Opiyo, Celso Alafo, Ellie Sherrard-Smith, Arlindo Malheia, Nelson Cuamba, et al. "Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique." PLOS ONE 16, no. 8 (August 5, 2021): e0248604. http://dx.doi.org/10.1371/journal.pone.0248604.
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Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™ 50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018–2019 malaria season. Using a susceptible Anopheles arabiensis strain, residual efficacy was assessed on two different wall surfaces, cement and mud-plastered walls, using standard WHO (World Health Organization) cone bioassay tests at three different heights. Female mosquitoes of two age groups (2–5 and 13–26 day old) were exposed for 30 minutes, after which mortality was observed 24h, 48h, 72h, and 96h and 120h post-exposure to assess (delayed) mortality. Lethal times (LT) 90, LT50 and LT10 were estimated using Bayesian models. Mortality 24h post exposure was consistently below 80%, the current WHO threshold value for effective IRS, in both young and old mosquitoes, regardless of wall surface type. Considering delayed mortality, residual efficacies (mosquito mortality equal or greater than 80%) ranged from 1.5 to ≥12.5 months, with the duration depending on mortality time post exposure, wall type and mosquito age. Looking at mortality 72h after exposure, residual efficacy was between 6.5 and 9.5 months, depending on wall type and mosquito age. The LT50 and LT10 (i.e. 90% of the mosquitoes survive exposure to the insecticides) values were consistently higher for older mosquitoes (except for LT10 values for 48h and 72h post-exposure mortality) and ranged from 0.9 to 5.8 months and 0.2 to 7.8 months for LT50 and LT10, respectively. The present study highlights the need for assessing mosquito mortality beyond the currently recommended 24h post exposure. Failure to do so may lead to underestimation of the residual efficacy of IRS products, as delayed mortality will lead to a further reduction in mosquito vector populations and potentially negatively impact disease transmission. Monitoring residual efficacy on relevant wall surfaces, including old mosquitoes that are ultimately responsible for malaria transmission, and assessing delayed mortalities are critical to provide accurate and actionable data to guide vector control programmes.
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Yuan, Ye, Fan Li, Yanning Fu, and Shulin Ren. "New precise positions in 2013–2019 and a catalog of ground-based astrometric observations of 11 Neptunian satellites (1847–2019) based on Gaia-DR2." Astronomy & Astrophysics 645 (January 2021): A48. http://dx.doi.org/10.1051/0004-6361/202038776.
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Context. Developing high-precision ephemerides for Neptunian satellites requires not only the continuation of observing campaigns but also the collection and improvement of existing observations. So far, no complete catalogs of observations of Neptunian satellites are available. Aims. We aim to provide new, precise positions, and to compile a catalog including all available ground-based astrometric observations of Neptunian satellites. The observations are tabulated in a single and consistent format and given in the same timescale, the Terrestrial Time (TT), and reference system, the International Celestial Reference System (ICRS), including necessary changes and corrections. Methods. New CCD observations of Triton and Nereid were made at Lijiang 2.4-m and Yaoan 0.8-m telescopes in 2013–2019, and then reduced based on Gaia-DR2. Furthermore, a catalog called OCNS2019 (Observational Catalog of Neptunian Satellites (2019 version)) was compiled, after recognizing and correcting errors and omissions. Furthermore, in addition to what was considered for the COSS08 catalog for eight main Saturnian satellites, all observed absolute and relative coordinates were converted to the ICRS with corrections for star catalog biases with respect to Gaia-DR2. New debiasing tables for both the modern and old star catalogs, which were previously not provided based on Gaia-DR2, are developed and applied. Treatment of missing positions of comparison bodies in conversions of observed relative coordinates are proposed. Results. OCNS2019 and the new debiasing tables are publicly available online. OCNS2019 includes 24996 observed coordinates of 11 Neptunian satellites obtained over 3741 nights from 1847 to 2019. All observations are given in TT and ICRS. The star catalog biases are removed, which are significant for Nereid and outer satellites. We obtained 880 (5% of total now available) new coordinates for Triton over 41 nights (1% of total observation nights so far), and 790 (14%) for Nereid over 47 nights (10%). The dispersions of these new positions are about 0.″03 for Triton and 0.″06 for Nereid. Conclusions. OCNS2019 should be useful in improving ephemerides for the above-mentioned objects.
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Yuan, Ye, Fan Li, Yanning Fu, and Shulin Ren. "New precise positions in 2013–2019 and a catalog of ground-based astrometric observations of 11 Neptunian satellites (1847–2019) based on Gaia-DR2." Astronomy & Astrophysics 645 (January 2021): A48. http://dx.doi.org/10.1051/0004-6361/202038776.
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Context. Developing high-precision ephemerides for Neptunian satellites requires not only the continuation of observing campaigns but also the collection and improvement of existing observations. So far, no complete catalogs of observations of Neptunian satellites are available. Aims. We aim to provide new, precise positions, and to compile a catalog including all available ground-based astrometric observations of Neptunian satellites. The observations are tabulated in a single and consistent format and given in the same timescale, the Terrestrial Time (TT), and reference system, the International Celestial Reference System (ICRS), including necessary changes and corrections. Methods. New CCD observations of Triton and Nereid were made at Lijiang 2.4-m and Yaoan 0.8-m telescopes in 2013–2019, and then reduced based on Gaia-DR2. Furthermore, a catalog called OCNS2019 (Observational Catalog of Neptunian Satellites (2019 version)) was compiled, after recognizing and correcting errors and omissions. Furthermore, in addition to what was considered for the COSS08 catalog for eight main Saturnian satellites, all observed absolute and relative coordinates were converted to the ICRS with corrections for star catalog biases with respect to Gaia-DR2. New debiasing tables for both the modern and old star catalogs, which were previously not provided based on Gaia-DR2, are developed and applied. Treatment of missing positions of comparison bodies in conversions of observed relative coordinates are proposed. Results. OCNS2019 and the new debiasing tables are publicly available online. OCNS2019 includes 24996 observed coordinates of 11 Neptunian satellites obtained over 3741 nights from 1847 to 2019. All observations are given in TT and ICRS. The star catalog biases are removed, which are significant for Nereid and outer satellites. We obtained 880 (5% of total now available) new coordinates for Triton over 41 nights (1% of total observation nights so far), and 790 (14%) for Nereid over 47 nights (10%). The dispersions of these new positions are about 0.″03 for Triton and 0.″06 for Nereid. Conclusions. OCNS2019 should be useful in improving ephemerides for the above-mentioned objects.
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Frietsch, Jochen J., Nils Winkelmann, Friederike Hunstig, Ulf Schnetzke, Friedrich J. Hammersen, Torsten Dönicke, Mark Lenz, et al. "A Mosquito Bite with Devastating Complications in an Immunocompromised Patient." Case Reports in Oncology 12, no. 1 (January 4, 2019): 22–28. http://dx.doi.org/10.1159/000495878.
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Infectious complications such as invasive aspergillosis or infection with Stenotrophomonas maltophilia (SM) in immunocompromised patients are associated with a high mortality rate. Our report concerns a 40-year-old male newly diagnosed very severe aplastic anemia (vSAA) who in consequence of a mosquito bite was suffering from skin lesion and consecutive soft tissue phlegmon subsequent to the administration of antithymocyte globulin; a full-thickness autologous meshed skin graft successfully performed to cover skin ulcera after allogeneic stem cell transplantation (SCT). This unusual case illustrates the importance of appropriate diagnosis, anti-infective therapy and close interdisciplinary diagnostic algorithms to minimalize side effects and the selection of resistant strains and to improve patients’ outcome.
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Sarmiento-Senior, Diana, María Inés Matiz, Juan Felipe Jaramillo-Gómez, Víctor Alberto Olano, Sandra Lucía Vargas, Neal Alexander, Audrey Lenhart, Thor Axel Stenström, and Hans Jörgen Overgaard. "Knowledge, attitudes, and practices about dengue among pupils from rural schools in an endemic area in Colombia." Biomédica 39, no. 3 (September 1, 2019): 478–90. http://dx.doi.org/10.7705/biomedica.4255.
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Introduction: Dengue is a public health problem in tropical and subtropical regions of the world. Studies on dengue in rural areas are scarce since the disease is considered mainly urban.Objective: To determine the knowledge (K), attitudes (A) and practices (P) of dengue in an endemic area in Colombia.Materials and methods: We conducted a cross-sectional study with 515 pupils (7-16 years old) in 34 rural schools in Anapoima and La Mesa municipalities during 2011. Each KAP category was evaluated independently by a scoring system and then categorized into high, medium or low.Results: Pupils recognized knowledge variables such as the symptoms (fever, bone pain), transmission route (mosquito bites), and mosquito breeding sites (uncovered water tanks, solid waste). Average scores on attitude were high in both municipalities indicating a well-developed perception of disease severity. Seeking treatment in medical centers and self-medication for fever management and the use of mosquito net and space-spraying of insecticides were the most frequently identified practices.Discussion: This is the first KAP dengue study performed in a rural area in Colombia and as such it contributes to the understanding of dengue perceptions by the inhabitants of these areas. It showed a medium level of knowledge about dengue and a lower level of preventive practices in pupils from rural schools. It also showed that pupils considered space-spraying as crucial for vector control. The presence of the vector in rural areas of the country underlines the need to improve surveillance and education to more effectively control the vector and promote prevention methods including community participation.
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Agbor, Okemena V., Taiwo E. Idowu, Kayode I. Fagbohun, Amos T. Oyeniyi, Romoke T. Jimoh, and Adetoro O. Otubanjo. "Molecular Identification and Insecticide Resistance Status of Culex mosquitoes collected from blocked drainages in Lagos State, Nigeria." Pan African Journal of Life Sciences 4, no. 1 (April 1, 2020): 1–6. http://dx.doi.org/10.36108/pajols/0202/40(0110).
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Background: Culex mosquitoes are important vectors of several human pathogens causing infections such as lymphatic filariasis and several viruses. Poor and blocked drainage system can lead to impediment in water flow, leading to the artificial creation of larval habitats for Culex mosquitoes. Culex mosquitoes has the ability to breed in organically polluted water bodies and exhibit high resistance to insecticides. Therefore, this study assessed the species and insecticides susceptibility status of Culex breeding in blocked drainages in Lagos State. Methods: Culex mosquito larvae were collected from blocked drainages in three Local Government Areas (LGAs) of Lagos State, Nigeria, using standard WHO technique. The physicochemical parameters of the larval habitats were also recorded. Collected mosquito larvae were raised to adult, 2-3 days old. Glucose fed adults female mosquitoes were exposed to permethrin (0.75%) and DDT (4.0%) WHO insecticide test papers. Morphological identification was carried out using standard keys and molecular identification of Culex pipiens sub-species and kdr genotyping was carried out using PCR Results: High level of resistance was recorded with mortality r ate after 24 hour s for DDT ranging from 20% to 32% while permethrin ranges from 14% to 36%. The pH of the all the Culex mosquito larva habitats ranges from 7.38±0.11 to 7.62±0.29, while TDS ranges from 592.6±79.1 to 655±68.1. A total of 1113 Culex pipiens mosquitoes that were identify morphologically, some were selected for molecular identification using PCR assays, out of which 96.2% were identified as Culex p. quinquefasciatus while 3.7% were unidentified. Knockdown mutation (L1014F) was not detected in DDT and pyrethroids resistant Cx. quinquefasciatus in this study. Conclusion: Unplanned ur banization, inadequate w ater su pply and inefficient solid w aste and sewage management practices can result in the creation artificial larval habitats for Culex mosquitoes leading to potential outbreak of Culex mosquito borne diseases. The resistance to DDT and permethrin insecticides in Cx. quinquefasciatus in Lagos State may represent a threat towards the efficacy of ITNs and other forms of vector control such as indoor residual spraying in the future.
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Sallares, Robert, Abigail Bouwman, and Cecilia Anderung. "The Spread of Malaria to Southern Europe in Antiquity: New Approaches to Old Problems." Medical History 48, no. 3 (July 1, 2004): 311–28. http://dx.doi.org/10.1017/s0025727300007651.
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The discoveries in the late nineteenth century that malaria is caused by protozoan parasites, which are transmitted by mosquitoes, quickly led to intense speculation about its history in antiquity. The historiography of malaria has passed through three distinct phases during the last hundred years or so. The first generation of historians to consider the effects of malaria did exaggerate its significance in some respects. The argument by W H S Jones that the Greek doctrine of fevers was based on malaria was generally and rightly accepted. However, it is not surprising that his view that malaria was a major reason for the degeneration of the moral character of the ancient Greeks attracted little sympathy. The eradication of malaria from southern Europe in the 1930s and 1940s contributed to a decline of interest in the subject. Subsequently medical historians and even professional malariologists tended to minimize the historical significance of malaria. The revisionist tendencies of this second phase of research led to attempts to reassess some of the details of the evidence upon which Jones had relied. For example, Leonard Bruce-Chwatt and Julian de Zulueta rejected Jones's belief that Plasmodium falciparum, the most dangerous of the four species of human malaria, was already active in Greece in the fifth century BC. They suggested that it started to spread in southern Europe only during the time of the Roman Empire and attributed all the references to intermittent tertian fevers in Hippocratic texts dating to the fifth and fourth centuries BC to the less virulent P. vivax. Although the literature produced during this second phase of scholarship was in many ways more sophisticated, it still suffered from some of the same weaknesses; in particular, analysis proceeded in a purely qualitative manner, without any consideration of the effects of malaria on historical human populations in quantitative terms. A second weakness was a tendency to make generalizations covering the whole of Mediterranean Europe. Since many types of mosquito are incapable of transmitting malaria to humans, mosquito breeding sites do not occur everywhere, and many mosquitoes do not fly further than a few hundred yards from their breeding sites, malaria can only be really understood by micro-analyses, conducted at a very local level, of geography, hydrology, climate, competition between different species of mosquito for breeding sites, and human activities.
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Labruzzo, Andrea, Charles L. Cantrell, Alessandra Carrubba, Abbas Ali, David E. Wedge, and Stephen O. Duke. "Phytotoxic Lignans from Artemisia arborescens." Natural Product Communications 13, no. 3 (March 2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300302.
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A systematic bioassay-guided fractionation of methylene chloride extracts of the aerial part of Artemisia arborescens was performed in order to identify its phytotoxic compounds Two lignans were isolated, sesamin and ashantin, that inhibited growth of Agrostis stolonifera (bentgrass), a monocot, and Lactuca sativa (lettuce), a dicot, at 1 mg mL–1. In a dose-response screening of these lignans for growth inhibition against Lemna paucicostata (duckweed), ashantin was the most active with an IC50 of ca. 224 μM. The mode of action of these compounds is still unknown. In mosquito larvicidal bioassays the pure compounds sesamin and ashantin did not cause mortality at the highest dose of 125 mg/L against 1-d-old Aedes aegypti larvae. In bioautography bioassays for antifungal activity using Botrytis cinerea, Fusarium oxysporum, Colletotrichum fragariae, Colletotrichum acutatum, and Colletotrichum gloeosporioides, ashantin and sesamin were inactive at 5 μg and were therefore not subjected to additional screening in secondary antifungal assays.
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Greenwalt, Dale, Timothy R. Rose, and Stylianos Chatzimanolis. "Preservation of mandibular zinc in a beetle from the Eocene Kishenehn Formation of Montana, USA." Canadian Journal of Earth Sciences 53, no. 6 (June 2016): 614–21. http://dx.doi.org/10.1139/cjes-2015-0157.
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Fossil insects of the 46 million-year-old Coal Creek Member of the Kishenehn Formation exhibit exceptional preservation as evidenced by the preservation of color and the blood-derived pigment heme in a blood-engorged mosquito. In the present study, analysis of a fossil rove beetle (Coleoptera: Staphylinidae) from the Kishenehn Formation document preservation of zinc, a metal often used to harden the cutting surfaces of mandibles in extant insects, localized to the mandibles of the fossil insect. Scanning electron microscopy and energy-dispersive X-ray spectroscopy demonstrate that the carbonaceous bodies of preserved insects are physically homogeneous, composed primarily of carbon, and are distinct from the adjacent microbial mat within which the insects are thought to have been preserved. The microbial mat that covered the fossil insects is shown to consist of, in part, well-consolidated silicates. This thin layer, while completely transparent when wet, obscures the fossil when dry. The in situ preservation of components such as mandibular zinc and mosquito host blood-derived heme demonstrate that the carbonaceous bodies of Kishenehn Formation fossil insects contain some portion of their original contents. The thin layer of silicate-embedded mat may function to stabilize the fossil and its molecular components and may explain, in part, the exceptional preservation of the Kishenehn Formation fossils.
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Marquis, Kathy. "Peter Devereaux and Carla Diane Hayden. The Card Catalog: Books, Cards, and Literary Treasures." RBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage 19, no. 1 (May 17, 2018): 71. http://dx.doi.org/10.5860/rbm.19.1.71.
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In an early archives job, I typed the name and subject entries at the top of card sets we received from the Library of Congress. It was exacting work and I really enjoyed it, including the filing. At a venerable manuscript repository, the cards ranged from the printed ones I placed on top of the rods (to be double-checked before they slipped into their forever homes) and those written in a spidery handwriting that could easily have been 100 years old. It made me feel part of a long tradition of information mavens.
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Kumkova, Irina I., Vadim V. Bobylev, and Nina M. Bronnikova. "Densification of ICRS in the Optical by use of Old Pulkovo Observation Sets." International Astronomical Union Colloquium 180 (March 2000): 61–67. http://dx.doi.org/10.1017/s0252921100000117.
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AbstractModern tasks of high precision astrometry demand optical coordinate systems including more faint stars than are available now in current conventional systems (Hipparcos). For this purpose it is suggested to use old photographic observations accumulated in the Pulkovo Observatory. Extensive observational data have been obtained at Pulkovo Observatory during the last century in the framework of several programs, e.g. Pulkovo Galaxy plan, etc. Observations have been made with the Normal Astrograph from 1894 to the present. The data are investigated with the aim of extending the Hipparcos catalog to stars fainter than 11th magnitude. All available observations are taken into account. A description of the material considered is given. The distribution of the selected plates over the celestial sphere is shown as well. Coordinates of faint stars in the Hipparcos system are calculated for selected areas. The accuracy of computed star coordinates is analyzed. Results of the investigation are presented.
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KS, Anjana, Raghunath CN, and Arvind C. "Acute Kidney Injury as a Rare Complication of Prallethrin Poisoning (“All-Out”) in a Child." Open Urology & Nephrology Journal 12, no. 1 (July 31, 2019): 53–55. http://dx.doi.org/10.2174/1874303x01912010053.
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Pyrethroids are widely used as commercial and domestic insecticides due to their high effectiveness and low toxicity in humans and in medicine for the topical treatment of scabies and head lice. Prallethrin is a structural derivative of naturally occurring pyrethrin and active ingredient in liquid mosquito repellents. Acute human poisoning from exposure or ingestion of pyrethroids is rare because of poor dermal absorption and rapid metabolism with little tissue accumulation. Here we present a case of accidental Prallethrin poisoning(“ALL –OUT”, a liquid mosquito repellent) in a five year old child who had immediate complication as hypovolemic shock with aspiration pneumonia and delayed complications like acute kidney injury, with elevated liver enzymes, requiring renal replacement therapy and had an uneventful recovery.
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TIAN, JIAHUI, and LIHONG TU. "A new species of the spider genus Solenysa from China (Araneae, Linyphiidae)." Zootaxa 4531, no. 1 (December 11, 2018): 142. http://dx.doi.org/10.11646/zootaxa.4531.1.10.
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The genus Solenysa Simon, 1894 belongs to Linyphiidae Blackwall, 1859, which is a species-rich group, including 608 genera and 4,571 species (World Spider Catalog 2018). Solenysa currently includes 14 species from China, Japan and the Korean Peninsula (Simon 1894; Namkung 1986; Li & Song 1992; Gao, Zhu & Sha 1993; Tu, Ono & Li 2007; Ono 2011; Tu & Hormiga 2011; Wang, Ono & Tu 2015). The linyphiid phylogeny based on molecular data shows that Solenysa species forms one of the seven main clades within Linyphiidae (Wang et al. 2015). According to the phylogenetic analysis based on morphological data, Tu and Hormiga (2011) divided the genus Solenysa into four species groups, each having a unique genital type comprised by series genital characters. As an old branch with a long evolutionary history, Solenysa spiders have accumulated a long list of synapomorphies (Tu & Hormiga 2011), not only having a unique somatic appearance, but also specific genitalic characters that distinguish them from all other linyphiids.
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Buser, Roland, and Jianxiang Rong. "Metallicity Structures of the Milky Way." Symposium - International Astronomical Union 169 (1996): 427–28. http://dx.doi.org/10.1017/s0074180900230040.
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The metallicity-sensitive (U – G) colors from the new homogeneous catalog of photographic RGU data in seven high-latitude fields have been used to determine the larger-scale metallicity distributions of the Galactic population components. For the thick disk, preliminary analysis based on our best structural models provides a mean metallicity 〈[M/H]〉 = −0.6 ± 0.3dex and a marginal vertical metallicity gradient ≈ −0.1dex/kpc. The observed color distributions are further consistent with the (old) thin disk having mean abundance 〈[M/H]〉 = −0.3 ± 0.2dex and abundance gradient ∂[M/H]/∂z = −0.6dex/kpc.
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Healy, Kristen B., Emily Dugas, and Dina M. Fonseca. "Development of a Degree-Day Model to Predict Egg Hatch of Aedes albopictus." Journal of the American Mosquito Control Association 35, no. 4 (December 1, 2019): 249–57. http://dx.doi.org/10.2987/19-6841.1.
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ABSTRACT Aedes albopictus, the Asian tiger mosquito, is an important nuisance mosquito species and known vector of arboviruses such as dengue, chikungunya, and Zika. Despite their cosmopolitan distribution around the world, there is a paucity of accurate predictive models based on rates of development at different temperatures (degree-day models). These types of models can benefit mosquito control districts by predicting when to target early-season larval development, when populations are likely at their lowest levels. In this study, we determined the effect of temperature and nutrient levels on the development rates and male and female adult size of 2 Ae. albopictus populations: one field-collected, the other a 20-year-old lab colony. We found relatively small differences in the effects of temperature and nutrient levels between populations. Data from these studies were used to create a predictive degree-day model, which when tested in New Jersey correlated with field observations of early-season field populations of Ae. albopictus. While other important factors, such as day length and fluctuating temperatures, should be evaluated, data from this study will contribute to the development of operational strategies to effectively time early-season larviciding against this species.
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Khomutov, Sergey Y., and Manjula Lingala. "Some problems with old magnetic data processing." E3S Web of Conferences 196 (2020): 02029. http://dx.doi.org/10.1051/e3sconf/202019602029.
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Continues magnetic measurements at the IKIR FEB RAS obser-vatories Magadan (MGD), Paratunka (PET), Yuzhno-Sakhalinsk (YSS), Cape Schmidt (CPS) and Khabarovsk (KHB) and CSIR-NGRI observatories Hyder-abad (HYB) and Choutuppal (CPL) have been started almost since their formation. A significant part of the results obtained is presented in the WDC and INTERMAGNET databases. However, a large amount of raw data remains un-processed and unavailable for using by scientific community. In the past few years, institutes has been making efforts to process and reprocess old magnetic data. Digital images of analog magnetograms of the Observatory Paratunka since 1967 were obtained and the possibility of their use for calculation hourly and minute values of magnetic field elements was evaluated. Old digital data that was available during the conversion from analog to digital magnetometers is processed. The main problem of processing or re-processing archived data is the lack of information (metadata) about the measurement conditions. First of all, these are the results of absolute observations, which are necessary to obtain the values of the elements of the total field vector. In this paper, some technologies are proposed that allow to use the data obtained during processing of analog magnetograms to adjust the digital magnetometers records. A signif-icant problem is the lack or inaccuracy of information about the temperature conditions in the variation pavilion, about magnetometers or support equipment maintenance or about works in and near the pavilions. As we accumulate the experience during the processing of old magnetic data, a “catalog” of noise and its typical images is formed. This makes it more reliable and efficient to identify and remove this noise from records.
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Touray, Abdoulie O., Victor A. Mobegi, Fred Wamunyokoli, Hellen Butungi, and Jeremy K. Herren. "Prevalence of asymptomatic P. falciparum gametocyte carriage among school children in Mbita, Western Kenya and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence." Wellcome Open Research 5 (April 13, 2021): 259. http://dx.doi.org/10.12688/wellcomeopenres.16299.2.
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Background: Asymptomatic Plasmodium falciparum gametocyte carriers are reservoirs for sustaining transmission in malaria endemic regions. Gametocyte presence in the host peripheral blood is a predictor of capacity to transmit malaria. However, it does not always directly translate to mosquito infectivity. Factors that affect mosquito infectivity include, gametocyte sex-ratio and density, multiplicity of infection (MOI), and host and vector anti-parasite immunity. We assess the prevalence of gametocyte carriage and some of its associated risk factors among asymptomatic schoolchildren in Western Kenya and to further analyse the association between gametocyte density, multiplicity of infection (MOI) and mosquito infection prevalence. Methods: P. falciparum parasite infections were detected by RDT (Rapid Diagnostic Test) and microscopy among schoolchildren (5-15 years old). Blood from 37 microscopy positive gametocyte carriers offered to laboratory reared An. gambiae s.l. mosquitoes. A total of 3395 fully fed mosquitoes were screened for Plasmodium sporozoites by ELISA. P. falciparum was genotyped using 10 polymorphic microsatellite markers. The association between MOI and gametocyte density and mosquito infection prevalence was investigated. Results: A significantly higher prevalence of P. falciparum infection was found in males 31.54% (764/2422) (p-value < 0.001) compared to females 26.72% (657/2459). The microscopic gametocyte prevalence among the study population was 2% (84/4881). Children aged 5-9 years have a higher prevalence of gametocyte carriage (odds ratios = 2.1 [95% CI = 1.3–3.4], P = 0.002) as compared to children aged 10-15 years. After offering gametocyte positive blood to An. gambiae s.l. by membrane feeding assay, our results indicated that 68.1% of the variation in mosquito infection prevalence was accounted for by gametocyte density and MOI (R-SQR. = 0.681, p < 0.001). Conclusions: We observed a higher risk of gametocyte carriage among the younger children (5-9 years). Gametocyte density and MOI significantly predicted mosquito infection prevalence.
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Lewis, B. M. "Miras Without Masers are Symbiotic Stars." International Astronomical Union Colloquium 135 (1992): 241–43. http://dx.doi.org/10.1017/s0252921100006485.
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AbstractAbout 40% of potential OH / IR stars, color selected from the IRAS Point Source Catalog, have no 1612 MHz masers. While these objects are rarely carbon rich, they are usually associated with circumstellar shells. The natural explanation for these “OH / IR star color mimics” is that they are systems with a degenerate companion collecting an accretion disk from a red giant wind. This provides them with an extra source of UV for dissociating their molecules. The persistent absence of the usual complement of masers from an O-rich shell is then a pointer to the presence of a degenerate companion. These occur in association with ~45% of old giant stars.
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Kyaw, Pyae Phyo, Hemant Deepak Shewade, Nang Thu Thu Kyaw, Khaing Hnin Phyo, Htar Htar Lin, Aye Mon Mon Kyaw, Mg Mg Mya, Sein Thaung, and Yan Naung Maung Maung. "High vaccination coverage and inadequate knowledge: Findings from a community-based cross-sectional study on Japanese Encephalitis in Yangon, Myanmar." F1000Research 9 (September 8, 2020): 6. http://dx.doi.org/10.12688/f1000research.21702.3.
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Background: Japanese encephalitis (JE) is a mosquito-borne disease with high case fatality and no specific treatment. Little is known about the community’s (especially parents/guardians of children) awareness regarding JE and its vaccine in Yangon region, which bears the highest JE burden in Myanmar. Methods: We conducted a community-based cross-sectional study in Yangon region (2019) to explore the knowledge and perception of parents/guardians of 1-15 year-old children about JE disease, its vaccination and to describe JE vaccine coverage among 1-15 year-old children. We followed multi-stage random sampling (three stages) to select the 600 households with 1-15 year-old children from 30 clusters in nine townships. Analyses were weighted (inverse probability sampling) for the multi-stage sampling design. Results: Of 600 parents/guardians, 38% exhibited good knowledge of JE, 55% perceived JE as serious in children younger than 15 years and 59% perceived the vaccine to be effective. Among all the children in the 600 households, the vaccination coverage was 97% (831/855). Conclusion: In order to reduce JE incidence in the community, focus on an intensified education program is necessary to sustain the high vaccine coverage in the community.
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Londono-Renteria, Berlin, Papa M. Drame, Jehidys Montiel, Ana M. Vasquez, Alberto Tobón-Castaño, Marissa Taylor, Lucrecia Vizcaino, and Audrey E. Lenhart. "Identification and Pilot Evaluation of Salivary Peptides from Anopheles albimanus as Biomarkers for Bite Exposure and Malaria Infection in Colombia." International Journal of Molecular Sciences 21, no. 3 (January 21, 2020): 691. http://dx.doi.org/10.3390/ijms21030691.
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Insect saliva induces significant antibody responses associated with the intensity of exposure to bites and the risk of disease in humans. Several salivary biomarkers have been characterized to determine exposure intensity to Old World Anopheles mosquito species. However, new tools are needed to quantify the intensity of human exposure to Anopheles bites and understand the risk of malaria in low-transmission areas in the Americas. To address this need, we conducted proteomic and bioinformatic analyses of immunogenic candidate proteins present in the saliva of uninfected Anopheles albimanus from two separate colonies—one originating from Central America (STECLA strain) and one originating from South America (Cartagena strain). A ~65 kDa band was identified by IgG antibodies in serum samples from healthy volunteers living in a malaria endemic area in Colombia, and a total of five peptides were designed from the sequences of two immunogenic candidate proteins that were shared by both strains. ELISA-based testing of human IgG antibody levels against the peptides revealed that the transferrin-derived peptides, TRANS-P1, TRANS-P2 and a salivary peroxidase peptide (PEROX-P3) were able to distinguish between malaria-infected and uninfected groups. Interestingly, IgG antibody levels against PEROX-P3 were significantly lower in people that have never experienced malaria, suggesting that it may be a good marker for mosquito bite exposure in naïve populations such as travelers and deployed military personnel. In addition, the strength of the differences in the IgG levels against the peptides varied according to location, suggesting that the peptides may able to detect differences in intensities of bite exposure according to the mosquito population density. Thus, the An. albimanus salivary peptides TRANS-P1, TRANS-P2, and PEROX-P3 are promising biomarkers that could be exploited in a quantitative immunoassay for determination of human-vector contact and calculation of disease risk.
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Alkan, Cigdem, Sonia Zapata, Laurence Bichaud, Grégory Moureau, Philippe Lemey, Andrew E. Firth, Tamara S. Gritsun, et al. "Ecuador Paraiso Escondido Virus, a New Flavivirus Isolated from New World Sand Flies in Ecuador, Is the First Representative of a Novel Clade in the Genus Flavivirus." Journal of Virology 89, no. 23 (September 9, 2015): 11773–85. http://dx.doi.org/10.1128/jvi.01543-15.
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ABSTRACTA new flavivirus, Ecuador Paraiso Escondido virus (EPEV), named after the village where it was discovered, was isolated from sand flies (Psathyromyia abonnenci, formerlyLutzomyia abonnenci) that are unique to the New World. This represents the first sand fly-borne flavivirus identified in the New World. EPEV exhibited a typical flavivirus genome organization. Nevertheless, the maximum pairwise amino acid sequence identity with currently recognized flaviviruses was 52.8%. Phylogenetic analysis of the complete coding sequence showed that EPEV represents a distinct clade which diverged from a lineage that was ancestral to the nonvectored flaviviruses Entebbe bat virus, Yokose virus, and Sokoluk virus and also theAedes-associated mosquito-borne flaviviruses, which include yellow fever virus, Sepik virus, Saboya virus, and others. EPEV replicated in C6/36 mosquito cells, yielding high infectious titers, but failed to reproduce either in vertebrate cell lines (Vero, BHK, SW13, and XTC cells) or in suckling mouse brains. This surprising result, which appears to eliminate an association with vertebrate hosts in the life cycle of EPEV, is discussed in the context of the evolutionary origins of EPEV in the New World.IMPORTANCEThe flaviviruses are rarely (if ever) vectored by sand fly species, at least in the Old World. We have identified the first representative of a sand fly-associated flavivirus, Ecuador Paraiso Escondido virus (EPEV), in the New World. EPEV constitutes a novel clade according to current knowledge of the flaviviruses. Phylogenetic analysis of the virus genome showed that EPEV roots theAedes-associated mosquito-borne flaviviruses, including yellow fever virus. In light of this new discovery, the New World origin of EPEV is discussed together with that of the other flaviviruses.
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Kyaw, Pyae Phyo, Hemant Deepak Shewade, Nang Thu Thu Kyaw, Khaing Hnin Phyo, Htar Htar Lin, Aye Mon Mon Kyaw, Mg Mg Mya, Sein Thaung, and Yan Naung Maung Maung. "High vaccination coverage, inadequate knowledge and high vector density: Findings from a community-based cross-sectional study on Japanese Encephalitis in Yangon, Myanmar." F1000Research 9 (January 6, 2020): 6. http://dx.doi.org/10.12688/f1000research.21702.1.
Full textAbstract:
Background: Japanese encephalitis (JE) is a mosquito-borne disease with high case fatality and no specific treatment. Little is known about the community’s (especially parents/guardians of children) awareness regarding JE and its vaccine in Yangon region, which bears the highest JE burden in Myanmar. Methods: We conducted a community-based cross-sectional study in Yangon region (2019) to explore the knowledge and perception of parents/guardians of 1-15 year-old children about JE disease, its vaccination and to describe JE vaccine coverage among 1-15 year-old children. We followed multi-stage random sampling (three stages) to select the 600 households with 1-15 year-old children from 30 clusters in nine townships. Analyses were weighted (inverse probability sampling) for the multi-stage sampling design. Results: Of 600 parents/guardians, 38% exhibited good knowledge of JE, 55% perceived JE as serious in children younger than 15 years and 59% perceived the vaccine to be effective. Among all the children in the 600 households, the vaccination coverage was 97% (831/855). Conclusion: In order to reduce JE incidence in the community, focus on an intensified education program is necessary to sustain the high vaccine coverage in the community.
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Kyaw, Pyae Phyo, Hemant Deepak Shewade, Nang Thu Thu Kyaw, Khaing Hnin Phyo, Htar Htar Lin, Aye Mon Mon Kyaw, Mg Mg Mya, Sein Thaung, and Yan Naung Maung Maung. "High vaccination coverage, inadequate knowledge and high vector density: Findings from a community-based cross-sectional study on Japanese Encephalitis in Yangon, Myanmar." F1000Research 9 (June 30, 2020): 6. http://dx.doi.org/10.12688/f1000research.21702.2.
Full textAbstract:
Background: Japanese encephalitis (JE) is a mosquito-borne disease with high case fatality and no specific treatment. Little is known about the community’s (especially parents/guardians of children) awareness regarding JE and its vaccine in Yangon region, which bears the highest JE burden in Myanmar. Methods: We conducted a community-based cross-sectional study in Yangon region (2019) to explore the knowledge and perception of parents/guardians of 1-15 year-old children about JE disease, its vaccination and to describe JE vaccine coverage among 1-15 year-old children. We followed multi-stage random sampling (three stages) to select the 600 households with 1-15 year-old children from 30 clusters in nine townships. Analyses were weighted (inverse probability sampling) for the multi-stage sampling design. Results: Of 600 parents/guardians, 38% exhibited good knowledge of JE, 55% perceived JE as serious in children younger than 15 years and 59% perceived the vaccine to be effective. Among all the children in the 600 households, the vaccination coverage was 97% (831/855). Conclusion: In order to reduce JE incidence in the community, focus on an intensified education program is necessary to sustain the high vaccine coverage in the community.
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Holcomb, Karen, Chilinh Nguyen, Brian D. Foy, and Christopher M. Barker. "4102 Assessment of ivermectin-treated backyard chickens as a novel urban West Nile virus prevention strategy." Journal of Clinical and Translational Science 4, s1 (June 2020): 123–24. http://dx.doi.org/10.1017/cts.2020.370.
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OBJECTIVES/GOALS: We conducted a randomized field trail to evaluate the efficacy and safety of a novel vector control strategy that involves treating urban backyard chickens with ivermectin (IVM), a widely used antiparasitic and mosquitocial drug. The goal was to reduce vector mosquito populations and West Nile virus (WNV) transmission. METHODS/STUDY POPULATION: We placed eight flocks—four treated and four untreated control—of six Lohmann brown chickens (16 month-old) each in backyard coops across Davis, CA and administered IVM in feed daily at treated coops (200 mg IVM/kg feed) for eleven weeks. We monitored entomological indices weekly (i.e. mosquito abundance, WNV infection prevalence, and parity rate) in Culex mosquito populations near (10 m) and far (150 m) from each coop location for the peak WNV transmission season (Jul-Sep 2019). We also monitored serum IVM levels in treated chickens and tested for WNV antibodies in all chickens throughout the study. RESULTS/ANTICIPATED RESULTS: Since IVM impacts only mosquitoes that live long enough to take a bloodmeal from a treated chicken, we do not expect to find a marked difference in adult Culex abundance between the two treatment arms, but we expect to find a reduction in WNV infection prevalence and a shift in female mosquito age structure towards younger, uninfected individuals at treated coops. We also anticipate seroconversions in treated chickens to occur at lower rates versus untreated control chickens indicating a reduction in WNV transmission intensity at treated coops. We observed no negative health outcomes from the long-term ingestion of IVM by study chickens. A pathological investigation is underway to compare histological findings between treated and untreated chickens. DISCUSSION/SIGNIFICANCE OF IMPACT: IVM provides the potential for targeted mosquito control. Reduced WNV transmission dynamics here is a stepping stone to a commercial WNV control strategy; IVM-treated feed for wild birds for homeowners’ use to combat WNV transmission in their neighborhoods.
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Chisthi, Meer M., and Aravind Reghukumar. "Dirofilarial worms inside cutaneous nodules: a report with review of literature." International Journal of Research in Dermatology 1, no. 1 (December 25, 2015): 24. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20160354.
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Dirofilaria is a filarial worm which affects humans as a zoonosis. The infection is carried by mosquito bite. In humans, the worm fails to achieve its full cycle and hence microfilaremia is absent. Apart from subcutaneous and subconjunctival locations, there are visceral and other presentations for the worm. Surgical removal and antihelminthic medications are the best options for treatment. We present a case of subcutaneous dirofilaria infection in a 13 year old boy from rural south India who presented with fever and a painless swelling on the leg. Detailed literature review is also enclosed.
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Westerhout, Gart. "Archiving of Data in Positional Astronomy." Highlights of Astronomy 9 (1992): 711–12. http://dx.doi.org/10.1017/s1539299600010121.
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Astrometry is the oldest of the astronomical endeavors. Indeed, we still have the observing journals of Galileo, the journals of Flamsteed, and those of most of the other old transit-circle astronomers. We have most of the early photographic plates taken for the astrographic catalog project, and almost all the parallax plates. However, as technology progressed, we have become somewhat less precise in recording what we did. It is for this reason that this joint meeting was called: to impress on the modern astronomer that, in general, he only extracts a fraction of the information from his observations, and that these observational data may, in the future, provide an invaluable source needed for the progress of the science.
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Bo, M. Del, M. G. Lattanzi, G. Massone, F. Porcu, F. Salvati, G. L. Deiana, A. Poma, and S. Uras. "The TOCAMM Project." International Astronomical Union Colloquium 178 (2000): 317–20. http://dx.doi.org/10.1017/s0252921100061431.
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AbstractThe TOCAMM (TOrino CAgliari Measuring Machine) project undertaken jointly between Torino and Cagliari Astronomical Observatories aimed to convert the old measuring machine ASCORECORD into an automatic and impersonal one. This program is intended to contribute to the link of the HIPPARCOS Catalogue to the ICRS through the determination of precise position of optical counterparts of 80 extragalactic radiosources taken from the IERS list and to investigate the astrometric accuracy of the Guide Star Catalog (version 1 and 2). The calibration test phase, carried out first at the Astronomical Observatory of Torino and after at Cagliari Observatory, where the machine has been now installed, indicate that the available positional accuracy is about 0.5 microns in both x and y coordinates.
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Githinji, Edward K., Lucy W. Irungu, Paul N. Ndegwa, Maxwell G. Machani, Richard O. Amito, Brigid J. Kemei, Paul N. Murima, et al. "Impact of Insecticide Resistance on P. falciparum Vectors’ Biting, Feeding, and Resting Behaviour in Selected Clusters in Teso North and South Subcounties in Busia County, Western Kenya." Journal of Parasitology Research 2020 (April 8, 2020): 1–11. http://dx.doi.org/10.1155/2020/9423682.
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Introduction. Behavioural resistance to insecticides restrains the efficacy of vector control tools against mosquito-transmitted diseases. The current study is aimed at determining the impact of insecticide resistance on major malaria vectors’ biting, feeding, and resting behaviour in areas with and areas without insecticide resistance in Teso North and Teso South, Busia County, Western Kenya. Methods. Mosquito larvae were sampled using a dipper, reared into 3-5-day-old female mosquitoes [4944] which were exposed to 0.75% permethrin and 0.05% deltamethrin using World Health Organization tube assay method. Blood meal, species identification, and kdr Eastgene PCRs were also performed on adult mosquitoes sampled using mosquito collection methods [3448]. Biting, feeding, resting, and exiting behaviours of field-collected mosquitoes from five selected clusters were analysed. Results. The lowest Kdr genotypic frequency (SS) proportion was found in female Anophelines collected in Kengatunyi at 58% while Rwatama had the highest genotypic frequency at 93%, thus susceptible and resistant clusters, respectively. The peak hour for mosquito seeking a human bite was between 0300 and 0400 hrs in the resistant cluster and 0400-0500 hrs in the susceptible cluster. The heterozygous mosquitoes maintained the known 2100-2200 hrs peak hour. There was a higher proportion of homozygous susceptible vectors (86.4%) seeking humans indoor than outdoor bitters (78.3%). Mosquito blood meals of human origin were 60% and 87% in susceptible Kengatunyi and resistant Rwatama cluster, respectively. There was significant difference between homozygous-resistant vectors feeding on human blood compared to homozygous susceptible mosquitoes (p≤0.05). The proportion of bovine blood was highest in the susceptible cluster. A higher proportion of homozygous-resistant anophelines were feeding and resting indoors. No heterozygous mosquito was found resting indoor while 4.2% of the mosquitoes were caught while exiting the house through the window. Discussion. A shift in resistant Anopheles gambiae sl highest peak hour of aggressiveness from 2100-2200 hrs to 0300-0400 hrs is a key change in its biting pattern. Due to the development of resistance, mosquitoes no longer have to compete against the time the human host enters into the formerly lethal chemical and or physical barrier in the form of long-lasting insecticide-treated net. No heterozygous LS mosquito rested indoors possibly due to disadvantages of heterozygosity which could have increased their fitness costs as well as energy costs in the presence of the insecticidal agents in the treated nets. Conclusions and recommendations. Out of bed biting by female mosquitoes and partial susceptibility may contribute to residual malaria transmission. Insecticide-resistant vectors have become more endophagic and anthropophillic. Hence, insecticidal nets, zooprophylaxis, and novel repellents are still useful chemical, biological, and physical barriers against human blood questing female mosquitoes. Further studies should be done on genetic changes in mosquitoes and their effects on changing mosquito behaviour.
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Zhong, Jing, Li Chen, Di Wu, Lu Li, Leya Bai, and Jinliang Hou. "Exploring open cluster properties with Gaia and LAMOST." Astronomy & Astrophysics 640 (August 2020): A127. http://dx.doi.org/10.1051/0004-6361/201937131.
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Context. In Gaia DR2, an unprecedented high level of precision has been reached at sub-milliarcsecond for astrometry and millimagnitudes for photometry. Using cluster members identified with the astrometry and photometry in Gaia DR2, we can obtain a reliable determination of cluster properties. However, because of the shortcomings of Gaia spectroscopic observations in dealing with densely crowded cluster regions, the RVs and metallicity values for cluster member stars from Gaia DR2 are still lacking. It is necessary to combine the Gaia data with the data from large spectroscopic surveys, such as LAMOST, APOGEE, GALAH, and Gaia-ESO. Aims. In this study our aim is to improve the cluster properties by combining the LAMOST spectra. In particular, we provide the list of cluster members with spectroscopic parameters as an add-value catalog in LAMOST DR5, which can be used to perform a detailed study for a better understanding of the stellar properties, by using their spectra and fundamental properties from the host cluster. Methods. We cross-matched the spectroscopic catalog in LAMOST DR5 with the identified cluster members in Cantat-Gaudin et al. (2018, A&A, 618, A93). We then used members with spectroscopic parameters to derive statistical properties of open clusters. Results. We obtained a list of 8811 members with spectroscopic parameters and a catalog of 295 cluster properties. The provided cluster properties include astrometric parameters, spectroscopic parameters, derived kinematic and orbital parameters, and isochrone fitting results. In addition, we study the radial and vertical metallicity gradient and age-metallicity relation with the compiled open clusters as tracers, finding slopes of −0.053 ± 0.004 dex kpc−1, −0.252 ± 0.039 dex kpc−1, and 0.022 ± 0.008 dex Gyr−1, respectively. The slopes of the metallicity distribution relation for young clusters (0.1 Gyr < Age < 2 Gyr) and the age-metallicity relation for clusters within 6 Gyr are both consistent with the literature results. In order to fully study the chemical evolution history in the disk, more spectroscopic observations for old and distant open clusters are needed for further investigation.
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Veronica, Donie Ajian, Arif Widyanto, and Budi Triyantoro. "STUDI FAKTOR – FAKTOR LINGKUNGAN FISIK RUMAH PENDERITA DBD DI WILAYAH KERJA PUSKESMAS PURWOKERTO SELATAN KABUPATEN BANYUMAS TAHUN 2014." Buletin Keslingmas 34, no. 2 (June 30, 2015): 46–58. http://dx.doi.org/10.31983/keslingmas.v34i2.3028.
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Dengue Hemorrhagic Fever (DHF) disease is an infection disease caused by Dengue virustransmitted primarily through bites of Aedes aegypti. Based on the Purwokerto Selatan Public HealthCenter repotrs the number of dengue cases incedence from January to December 2013 recorded 92cases.The research objective was to describe physical house environment factors of DHF patients atdistrict Purwokerto Selatan Public Health Center like height of place, rainfall, ilumination, air temperatur,air humidity, kind of breeding place, and mosquito larva density (C.I, H.I, B.I, ABJ). The sample caseswere all patients with dengue in the public health center Purwokerto Selatan 2013.The research result shows from 77 patient was observation as subyek of cases DHF with agebetween 11-15 years old are 14 people (18,18%), 66,23 % are man with total 51 people, 46, 75 % arestudents with total 36 people. Height of places average are 74 meters from surface of the sea. Rainfall3.940 mm. Average of ilumination for part in the house 130 lux, part out of the house 443 lux. Average airtemperature for part in the house 31oC, part out of the house 32oC. Average air humidity part in thehouse 66%, part out of the house 62%. Total container was found are 285 container. C.I=2,45%,H.I=9,09%, B.I=9,09%, dan ABJ=90,0%.Kind of breeding place was found are basin for bath, place for clean water, vase, dispenser,refrigerator, pail, aquarium, pond, second objects, and container for drink bird. Mosquito larva density C.Iborder fill from WHO, (≤ 5%), border fill from WHO H.I (≤ 10%), B.I border fill from WHO (≤ 50%), andABJ border fill from WHO (≥ 95%) because of that be needed do restraint for mosquito larva. Give asuggestion to all people for do
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Licon Luna, Rosa M., Eva Lee, Arno Müllbacher, Robert V. Blanden, Rod Langman, and Mario Lobigs. "Lack of both Fas Ligand and Perforin Protects from Flavivirus-Mediated Encephalitis in Mice." Journal of Virology 76, no. 7 (April 1, 2002): 3202–11. http://dx.doi.org/10.1128/jvi.76.7.3202-3211.2002.
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ABSTRACT The mechanism by which encephalitic flaviviruses enter the brain to inflict a life-threatening encephalomyelitis in a small percentage of infected individuals is obscure. We investigated this issue in a mouse model for flavivirus encephalitis in which the virus was administered to 6-week-old animals by the intravenous route, analogous to the portal of entry in natural infections, using a virus dose in the range experienced following the bite of an infectious mosquito. In this model, infection with 0.1 to 105 PFU of virus gave mortality in ∼50% of animals despite low or undetectable virus growth in extraneural tissues. We show that the cytolytic effector functions play a crucial role in invasion of the encephalitic flavivirus into the brain. Mice deficient in either the granule exocytosis- or Fas-mediated pathway of cytotoxicity showed delayed and reduced mortality. Mice deficient in both cytotoxic effector functions were resistant to a low-dose peripheral infection with the neurotropic virus.
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Pascal, A. D. "Cyrillic writing system: from Slavic to Romanian." Proceedings of SPSTL SB RAS, no. 3 (September 17, 2020): 5–10. http://dx.doi.org/10.20913/2618-7515-2020-3-5-10.
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The article is devoted to Cyrillic handwritten books of the XIII–XIX centuries, created in the Romanian principalities, and stored today in the manuscript collections of the Russian State Library. The uniqueness of the writing system, functioning in the principalities (Wallachia, Moldavia, Transylvania) since their political formation, is that it was a Cyrillic script based on the old Slavic language with a predominant Roman-speaking population. In course of the writing system’ development in the principalities, there was a transition from the Slavic font to the Latin one; the intermediate result of this transition was the creation of monuments written in Romanian language with Cyrillic script. The main stages of this process are considered by reference to the specific examples of unique handwritten books and their fragments that have become objects for collecting by scientists, antiquaries, and Old Believers, whose book collections have formed the basis of the handwritten collections of the Russian State Library. They are the oldest Cyrillic manuscripts and their fragments dated to the XII–XIV centuries, found on the territory of Romania, Slavic manuscripts, produced mainly in monasteries of principalities in the XV–XVII centuries, translations of individual words into the Romanian language in the rewritten Slavic texts in the XVI century; the glosses and comments in Romanian on the margins of Slavic manuscripts in the XVI–XVIII centuries; numerous notes in the Romanian language in the manuscripts of the XVI–XVIII centuries, made by owners and readers; translations of literary monuments, including bilingual (Slavic–Romanian) and trilingual (Slavic–Latin–Romanian) versions in the XVI–XVIII centuries; Romanian–Slavic and Slavic–Romanian dictionaries in the XVII–XVIII centuries; letters and their copies in the Romanian language (sureties) in the XVI–XIX centuries. The article is an intermediate outcome of studying and describing Cyrillic Romanian handwritten books in the collections of the Russian State Library, which will result in the publication of a hard–copy catalog.
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Lépine, Sébastien. "Where the Wild Young M Dwarfs Are: the SUPERBLINK Proper Motion Survey and a Search for Low-mass Moving Group Candidates." Proceedings of the International Astronomical Union 10, S314 (November 2015): 69–70. http://dx.doi.org/10.1017/s1743921315006365.
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AbstractThe SUPERBLINK survey catalogs all stars brighter than R = 19 mag and with proper motions larger than 40 mas yr−1, down to a declination of −33○. The catalog inevitably includes a significant fraction of the presumed low-mass members of several nearby young moving groups (Beta Pic, AB Dor, Tuc-Hor, Argus), or low-mass escapees from the Hyades and Pleiades clusters. We discuss opportunities and challenges in identifying the missing M dwarf members of these moving groups. While rounding up the majority of the potential M dwarf members of these groups, such samples are significantly affected by co-moving field stars, both young and old, due to the heavy clumping of the local field population in velocity space.
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Barmby, P., and M. Rafiei Ravandi. "Stellar populations in the outskirts of M31: the mid-infrared view." Proceedings of the International Astronomical Union 11, S321 (March 2016): 19–21. http://dx.doi.org/10.1017/s1743921316011054.
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AbstractThe mid-infrared provides a unique view of galaxy stellar populations, sensitive to both the integrated light of old, low-mass stars and to individual dusty mass-losing stars. We present results from an extended Spitzer/IRAC survey of M31 with total lengths of 6.6 and 4.4 degrees along the major and minor axes, respectively. The integrated surface brightness profile proves to be surprisingly difficult to trace in the outskirts of the galaxy, but we can also investigate the disk/halo transition via a star count profile, with careful correction for foreground and background contamination. Our point-source catalog allows us to report on mid-infrared properties of individual objects in the outskirts of M31, via cross-correlation with PAndAS, WISE, and other catalogs.
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Touray, Abdoulie O., Victor A. Mobegi, Fred Wamunyokoli, Hellen Butungi, and Jeremy K. Herren. "Prevalence of asymptomatic P. falciparum gametocyte carriage in schoolchildren and assessment of the association between gametocyte density, multiplicity of infection and mosquito infection prevalence." Wellcome Open Research 5 (October 29, 2020): 259. http://dx.doi.org/10.12688/wellcomeopenres.16299.1.
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Background: Malaria is a major public health threat in sub-Saharan Africa. Asymptomatic Plasmodium falciparum gametocyte carriers are potential infectious reservoirs for sustaining transmission in many malaria endemic regions. The aim of the study was to assess the prevalence of gametocyte carriage and some of its associated risk factors among asymptomatic schoolchildren in Western Kenya and further analyse the association between gametocyte density, multiplicity of infection (MOI) and mosquito infection prevalence. Methods: Rapid diagnostic tests were used to screen for P. falciparum parasite infection among schoolchildren (5-15 years old) and the results were verified using microscopy. Microscopy positive gametocyte carriers were selected to feed laboratory reared An. gambiae s.l. mosquitoes using membrane feeding method. Genomic DNA was extracted from dry blood spot samples and P. falciparum populations were genotyped using 10 polymorphic microsatellite markers. Assessment of the association between MOI and gametocyte density and mosquito infection prevalence was conducted. Results: A significantly higher prevalence of P. falciparum infection was found in males 31.54% (764/2422) (p-value < 0.001) compared to females 26.72% (657/2459). The microscopy gametocyte prevalence among the study population was 2% (84/4881). Children aged 5-9 years have a higher prevalence of gametocyte carriage (odds ratios = 2.1 [95% CI = 1.3–3.4], P = 0.002) as compared to children aged 10-15 years. After challenging An. gambiae s.l. by membrane feeding assay on gametocyte positive patient blood, our results indicate that 68.1% of the variation in mosquito infection prevalence is accounted for by gametocyte density and MOI (R-SQR. = 0.681, p < 0.001). Conclusions: Age was a significant risk factor for gametocyte carriage, as indicated by the higher risk of gametocyte carriage among the younger children (5-9 years). Gametocyte density and MOI statistically significantly predicted mosquito infection prevalence. Both of the variables added significantly to the prediction (p < 0.05).
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Junnila, Amy. "PERFORMANCE OF THE ATRAKTA™ MOSQUITO LURE IN COMBINATION WITH DYNATRAP® (MODELS DT160 AND DT700) AND A CDC TRAP (MODEL 512)." Journal of the Florida Mosquito Control Association 68, no. 1 (June 10, 2021): 48–55. http://dx.doi.org/10.32473/jfmca.v68i1.129099.
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The performance of the three-part mosquito lure ATRAKTA (1-octen-3-ol, ammonium bicarbonate, and lactic acid) was evaluated in two DynaTrap commercial mosquito traps (models DT160 and DT700) as well as in one model of CDC trap (model 512). Lures were evaluated fresh from the factory, after being aged in functioning traps under field conditions, and after prolonged storage in the packaging (aged for 30 days aged in functioning traps before being tested in the DynaTrap models; and two years stored in the packaging before being tested in CDC traps). The primary study questions were whether the addition of lures would increase efficacy of various trap types and whether lures would retain effectiveness after a lengthy stay on the shelf or in traps. To do this, traps with no lures, new lures and old lures were used to trap three mosquito species (Aedes albopictus, Culex quinquefasciatus, and Anopheles gambiae) in the field in West Africa Mali, the first two species are also common North American nuisance mosquitoes. The addition of ATRAKTA lures aged 30 days to both DynaTrap® models, and ATRAKTA lures aged two years in the packaging to the CDC trap significantly increased catches of female Cx. quinquefasciatus and Ae. albopictus mosquitoes. Aged lures did not significantly lose their attraction in comparison to lures fresh from the factory. The addition of lures to traps resulted in slight increases in catches of An. gambiae, but these were not statistically significant. No effect of any lures on males was observed.
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Hodjati, M. H., and C. F. Curtis. "Evaluation of the effect of mosquito age and prior exposure to insecticide on pyrethroid tolerance in Anopheles mosquitoes (Diptera: Culicidae)." Bulletin of Entomological Research 89, no. 4 (April 1999): 329–37. http://dx.doi.org/10.1017/s0007485399000462.
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AbstractThe times for knockdown of resistant and susceptible strains of both Anopheles stephensi Liston (DUB234 and BEECH) and A. gambiae Giles (RSP and KWA), on exposure to a permethrin impregnated net were determined to evaluate the effect of age on susceptibility to permethrin. The mean knockdown times of pyrethroid resistant strains of A. stephensi and A. gambiae were significantly shorter if they were 10 days old (either fed or unfed), as compared with those of newly emerged mosquitoes. Based on KT50 values, the resistance ratios between resistant and susceptible A. stephensi were 3.5 and 2.2 for the newly emerged and 10-day-old mosquitoes, respectively. After 1 h exposure to paper impregnated with 0.25%permethrin, mortality of newly emerged individuals of the susceptible and resistant strains of A. stephensi was significantly less than when they were 10 days old. Irritability by permethrin was less with the resistant strain of A. stephensi. In the other strains irritability declined significantly with age. Pre-exposure of susceptible mosquitoes of BEECH and IRAQ strains of A. stephensi for a short time to permethrin did not increase tolerance when the mosquitoes were re-exposed 24 h later. Because of the age effect and the possibility of an effect of pre-exposure under some circumstances, confirmatory tests on newly emerged F1 individuals reared from wild collected mosquitoes are recommended in monitoring for resistance in wild populations.
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Benedict, Mark Q., Priscila Bascuñán, Catherine M. Hunt, Erica I. Aviles, Rachel D. Rotenberry, and Ellen M. Dotson. "Trials of the Automated Particle Counter for laboratory rearing of mosquito larvae." PLOS ONE 15, no. 11 (November 10, 2020): e0241492. http://dx.doi.org/10.1371/journal.pone.0241492.
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As a means of obtaining reproducible and accurate numbers of larvae for laboratory rearing, we tested a large-particle flow-cytometer type device called the ‘Automated Particle Counter’ (APC). The APC is a gravity-fed, self-contained unit that detects changes in light intensity caused by larvae passing the detector in a water stream and controls dispensing by stopping the flow when the desired number has been reached. We determined the accuracy (number dispensed compared to the target value) and precision (distribution of number dispensed) of dispensing at a variety of counting sensitivity thresholds and larva throughput rates (larvae per second) using < 1-day old Anopheles gambiae and Aedes aegypti larvae. All measures were made using an APC algorithm called the ‘Smoothed Z-Score’ which allows the user to define how many standard deviations (Z scores) from the baseline light intensity a particle’s absorbance must exceed to register a count. We dispensed a target number of 100 An. gambiae larvae using Z scores from 2.5–8 and observed no difference among them in the numbers dispensed for scores from 2.5–6, however, scores of 7 and 8 under-counted (over-dispensed) larvae. Using a Z score ≤ 6, we determined the effect of throughput rate on the accuracy of the device to dispense An. gambiae larvae. For rates ≤ 98 larvae per second, the accuracy of dispensing a target of 100 larvae was - 2.29% ± 0.72 (95% CI of the mean) with a mode of 99 (49 of 348 samples). When using a Z score of 3.5 and rates ≤ 100 larvae per second, the accuracy of dispensing a target of 100 Ae. aegypti was - 2.43% ± 1.26 (95% CI of the mean) with a mode of 100 (6 of 42 samples). No effect on survival was observed on the number of An. gambiae first stage larvae that reached adulthood as a function of dispensing.
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Ahmed, Qanta A., and Ziad A. Memish. "Yellow fever from Angola and Congo: a storm gathers." Tropical Doctor 47, no. 2 (April 2017): 92–96. http://dx.doi.org/10.1177/0049475517699726.
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In common with Zika, Chikungunya and Dengue, Yellow Fever (YF) is an arthropod-borne flavivirus. It is transmitted between humans and from monkeys by mosquitoes of the Aedes aegypti (its principal vector), haemogogus and albopictus varieties. Three cycles of transmission may occur: urban; sylvatic; and intermediate. Recently, sub-Saharan Africa has seen the resurgence of this neglected disease. The current YF outbreak in Angola began in December 2015 in the capital Luanda and by October 2016 there had been > 4300 suspected cases, with 376 deaths (case fatality rate = 8.8%). A total of 884 were laboratory confirmed but it is likely that case numbers may be seriously underestimated. YF has subsequently quickly spread to neighbouring Congo and further afield to Kenya and also China, this being of grave concern as this was a first introduction of YF to Asia. YF has recently hit Brazil, with 555 suspected cases and 107 deaths reported by the end of January 2017. Extremely rapid unplanned urban migration in Africa by non-immune rural populations to already densely populated cities, where high densities of mosquitoes co-exist with city dwellers in makeshift flimsy accommodation, poses a ready recipe for an epidemic of massive proportion. In such conditions, with enormously strained public services existing among the most needy and vulnerable populations, mosquito control programmes are nearly impossible. YF in Congo is a tempest barely restrained. However, it is one that can be controlled by focused and committed international collaboration, by intense and united political will and by the marriage of old and trusted techniques: a vaccine almost a century old and some of the most modern technologies available to man.
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Xie, Guorui, Huanle Luo, Lan Pang, Bi-hung Peng, Evandro Winkelmann, Brenna McGruder, Joseph Hesse, et al. "Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice." Journal of Virology 90, no. 3 (November 18, 2015): 1333–44. http://dx.doi.org/10.1128/jvi.02488-15.
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ABSTRACTThe elderly are known to have enhanced susceptibility to infections and an impaired capacity to respond to vaccination. West Nile virus (WNV), a mosquito-borne flavivirus, has induced severe neurological symptoms, mostly in the elderly population. No vaccines are available for human use. Recent work showed that an attenuated WNV, a nonstructural (NS) 4B-P38G mutant, induced no lethality but strong immune responses in young (6- to 10-week-old) mice. While studying protective efficacy, we found unexpectedly that old (21- to 22-month) mice were susceptible to WNV NS4B-P38G mutant infection but were protected from subsequent lethal wild-type WNV challenge. Compared to responses in young mice, the NS4B-P38G mutant triggered higher inflammatory cytokine and interleukin-10 (IL-10) production, a delayed γδ T cell expansion, and lower antibody and WNV-specific T cell responses in old mice. Toll-like receptor 7 (TLR7) is expressed on multiple types of cells. Impaired TLR7 signaling in old mice led to dendritic cell (DC) antigen-presenting function compromise and a reduced γδ T cell and regulatory T cell (Treg) expansion during NS4B-P38G mutant infection. R848, a TLR7 agonist, decreased host vulnerability in NS4B-P38G-infected old mice by enhancing γδ T cell and Treg expansion and the antigen-presenting capacity of DCs, thereby promoting T cell responses. In summary, our results suggest that dysregulation of TLR7 partially contributes to impaired innate and adaptive T cell responses and an enhanced vulnerability in old mice during WNV NS4B-P38G mutant infection. R848 increases the safety and efficacy during immunization of old mice with the WNV NS4B-P38G mutant.IMPORTANCEThe elderly are known to have enhanced susceptibility to infections and an impaired capacity to respond to vaccination. West Nile virus (WNV), an emerging mosquito-borne flavivirus, has induced severe neurological symptoms more frequently in the elderly population. No vaccines are available for human use. Here, we used an aged mouse model to investigate the protective efficacy of an attenuated WNV, the nonstructural 4B-P38G mutant, which was previously shown to induce no lethality but strong immune responses in young adult mice. Studies that contribute to a mechanistic understanding of immune defects in the elderly will allow the development of strategies to improve responses to infectious diseases and to increase vaccine efficacy and safety in aging individuals.
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Doum, Dyna, Hans J. Overgaard, Mayfong Mayxay, Sutas Suttiprapa, Prasert Saichua, Tipaya Ekalaksananan, Panwad Tongchai, et al. "Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos." International Journal of Environmental Research and Public Health 17, no. 23 (December 7, 2020): 9134. http://dx.doi.org/10.3390/ijerph17239134.
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Dengue is the most rapidly spreading mosquito-borne viral disease in the world. The detection of clinical cases enables us to measure the incidence of dengue infection, whereas serological surveys give insights into the prevalence of infection. This study aimed to determine dengue seroprevalence and seroconversion rates in northeastern Thailand and southern Laos and to assess any association of mosquito control methods and socioeconomic factors with dengue virus (DENV) infection. Cross-sectional seroprevalence surveys were performed in May and November 2019 on the same individuals. Blood samples were collected from one adult and one child, when possible, in each of 720 randomly selected households from two urban and two rural sites in both northeastern Thailand and southern Laos. IgG antibodies against DENV were detected in serum using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Overall, 1071 individuals participated in the study. The seroprevalence rate was high (91.5%) across all 8 study sites. Only age and province were associated with seroprevalence rates. There were 33 seroconversions during the period from May to November, of which seven reported fever. More than half of the seroconversions occurred in the rural areas and in Laos. Dengue seroconversion was significantly associated with young age (<15 years old), female gender, province, and duration of living in the current residence. No socioeconomic factors or mosquito control methods were found to be associated with seroprevalence or seroconversion. Notably, however, the province with most seroconversions had lower diurnal temperature ranges than elsewhere. In conclusion, our study has highlighted the homogeneity of dengue exposure across a wide range of settings and most notably those from rural and urban areas. Dengue can no longer be considered to be solely an urban disease nor necessarily one linked to poverty.
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van Reijmersdal, Eva A., Esther Rozendaal, and Moniek Buijzen. "Boys’ responses to the integration of advertising and entertaining content." Young Consumers 16, no. 3 (August 17, 2015): 251–63. http://dx.doi.org/10.1108/yc-10-2014-00487.
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Purpose – The purposes of this paper are to investigate the effects of integrated advertising formats on the persuasion of children, children’s awareness of the persuasive intent of these formats and how this awareness mediates the level of persuasion. Design/methodology/approach – An one-factor between-subjects experiment was conducted among 117 boys from 8 to 12 years old. Findings – This study showed that boys were more aware of the persuasive intent of a non-integrated catalog than of a brand-integrated magazine. In addition, higher awareness of the persuasive intent of the catalog enhanced persuasion in boys. Research limitations/implications – This study only focused on boys’ responses and not on girls. Practical implications – Findings imply that advertisers could focus on non-integrated print advertising formats, such as catalogs, to promote positive product attitudes among boys. Catalogs are also a more ethical way of communicating to boys because boys are generally aware of catalogs’ persuasive intent. Social implications – This study implies that even if children have sufficient persuasion knowledge, they do not necessarily use it to critically evaluate advertising. Originality/value – This paper is the first to systematically test the differences in effects of brand-integrated magazines versus catalogs targeted toward children. Importantly, it shows that persuasion knowledge plays a fundamentally different role in the persuasion process of children than of adults: awareness of the persuasive intent of catalogs increases persuasion among boys, whereas previous studies among adults showed opposite results.
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Gerhardt, Reid. "West Nile Virus in the United States (1999–2005)." Journal of the American Animal Hospital Association 42, no. 3 (May 1, 2006): 170–77. http://dx.doi.org/10.5326/0420170.
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The accidental introduction of West Nile Virus into New York City from the Old World in 1999 resulted in an epidemic in humans, horses, and birds that swept to the west coast in just 3 years. The virus is transmitted by infective mosquitoes among susceptible native birds, which serve as amplifying hosts. Clinical disease occurs in humans and horses, but not enough virus is produced in their blood to infect other mosquitoes; therefore, humans and horses are considered dead-end hosts. Humans can best protect themselves by remaining indoors during periods of high mosquito activity and/or by using recommended repellents. Effective vaccines are available for horses.