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1

Aliotta, Eric, Kévin Moulin, Zhaohuan Zhang, and Daniel B. Ennis. "Simultaneous measurement of T2and apparent diffusion coefficient (T2+ADC) in the heart with motion-compensated spin echo diffusion-weighted imaging." Magnetic Resonance in Medicine 79, no. 2 (2017): 654–62. http://dx.doi.org/10.1002/mrm.26705.

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2

Spinner, Georg R., Deuster Constantin von, Kerem C. Tezcan, Christian T. Stoeck, and Sebastian Kozerke. "Bayesian intravoxel incoherent motion parameter mapping in the human heart." Journal of Cardiovascular Magnetic Resonance 19, no. 1 (2017): 85. https://doi.org/10.1186/s12968-017-0391-1.

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<strong>Background: </strong>Intravoxel incoherent motion (IVIM) imaging of diffusion and perfusion in the heart suffers from high parameter estimation error. The purpose of this work is to improve cardiac IVIM parameter mapping using Bayesian inference.<strong>Methods: </strong>A second-order motion-compensated diffusion weighted spin-echo sequence with navigator-based slice tracking was implemented to collect cardiac IVIM data in early systole in eight healthy subjects on a clinical 1.5 T CMR system. IVIM data were encoded along six gradient optimized directions with b-values of 0–300 s/mm<s
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Aliotta, Eric, Holden H. Wu, and Daniel B. Ennis. "Convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion-compensated diffusion-weighted MRI." Magnetic Resonance in Medicine 77, no. 2 (2016): 717–29. http://dx.doi.org/10.1002/mrm.26166.

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4

Kamimura, K., M. Nakajo, Y. Fukukura, et al. "Intravoxel Incoherent Motion in Normal Pituitary Gland: Initial Study with Turbo Spin-Echo Diffusion-Weighted Imaging." American Journal of Neuroradiology 37, no. 12 (2016): 2328–33. http://dx.doi.org/10.3174/ajnr.a4930.

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5

Liu, Yuan, Liu Hu, Lijuan Qian, et al. "Intravoxel incoherent motion diffusion-weighted imaging in nasopharyngeal carcinoma: comparison of the turbo spin-echo and echo-planar imaging techniques." Quantitative Imaging in Medicine and Surgery 14, no. 12 (2024): 9101–11. https://doi.org/10.21037/qims-24-1021.

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6

Mikayama, Ryoji, Hidetake Yabuuchi, Shinjiro Sonoda, et al. "Comparison of intravoxel incoherent motion diffusion-weighted imaging between turbo spin-echo and echo-planar imaging of the head and neck." European Radiology 28, no. 1 (2017): 316–24. http://dx.doi.org/10.1007/s00330-017-4990-x.

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7

Fournet, Gabrielle, Jing-Rebecca Li, Alex M. Cerjanic, Bradley P. Sutton, Luisa Ciobanu, and Denis Le Bihan. "A two-pool model to describe the IVIM cerebral perfusion." Journal of Cerebral Blood Flow & Metabolism 37, no. 8 (2016): 2987–3000. http://dx.doi.org/10.1177/0271678x16681310.

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IntraVoxel Incoherent Motion (IVIM) is a magnetic resonance imaging (MRI) technique capable of measuring perfusion-related parameters. In this manuscript, we show that the mono-exponential model commonly used to process IVIM data might be challenged, especially at short diffusion times. Eleven rat datasets were acquired at 7T using a diffusion-weighted pulsed gradient spin echo sequence with b-values ranging from 7 to 2500 s/mm2 at three diffusion times. The IVIM signals, obtained by removing the diffusion component from the raw MR signal, were fitted to the standard mono-exponential model, a
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8

Ahmed, Nooradean, Tareq Alrashidi, Sourav Bhaduri, Soham Mukherjee, and Harish Poptani. "Intravoxel Incoherent Motion (IVIM) Diffusion-Weighted Imaging to Assess Treatment Response of Choline Kinase Inhibition on GL261 Mouse Glioblastoma." Neuro-Oncology 24, Supplement_4 (2022): iv5. http://dx.doi.org/10.1093/neuonc/noac200.021.

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Abstract AIMS To monitor changes in IVIM parameters in response to JAS239 treatment in preclinical glioblastoma models. METHOD C57BL/6 mice were injected intracranially with 5x105 GL261 glioblastoma cells and tumours were observed on T2 weighted MRI. Mice were imaged on day 0 (T0, baseline), day 3 (T3), 6 (T6) of treatment and post-treatment day 10 (T10). IVIM DWI was performed using a single-shot spin-echo echo planar sequence and processed using Matlab to acquire IVIM parameters of f, D, and D*. RESULTS Percentage changes in values with respect to baseline from saline treated control mice we
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Sakamoto, Junichiro, Akiko Imaizumi, Yoshinori Sasaki, et al. "Comparison of accuracy of intravoxel incoherent motion and apparent diffusion coefficient techniques for predicting malignancy of head and neck tumors using half-Fourier single-shot turbo spin-echo diffusion-weighted imaging." Magnetic Resonance Imaging 32, no. 7 (2014): 860–66. http://dx.doi.org/10.1016/j.mri.2014.05.002.

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10

Dillman, Jonathan, Joel G. Fletcher, David Bruining, et al. "MRI AND BLOOD-BASED BIOMARKERS ASSOCIATED WITH SURGICAL MANAGEMENT IN CHILDREN AND ADULTS WITH SMALL BOWEL CROHN'S DISEASE." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S14—S15. http://dx.doi.org/10.1093/ibd/izae020.033.

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Abstract BACKGROUND Despite advances in medical therapy, many children and adults with ileal Crohn’s Disease (CD) progress to fibrostenosis requiring surgery. Prior studies have identified circulating and imaging biomarkers associated with strictures, although their associations with need for surgery are not well-established. PURPOSE We aimed to identify MRI and circulating biomarkers associated with the need for surgical management in chidlren and adults with ileal CD. METHODS This prospective, multi-center study included pediatric and adult CD cases undergoing ileal resection (n=50), and CD
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11

Chan, Si-Wa, Chun-An Lin, Yen-Chieh Ouyang, et al. "Characterizing Breast Tumor Heterogeneity Through IVIM-DWI Parameters and Signal Decay Analysis." Diagnostics 15, no. 12 (2025): 1499. https://doi.org/10.3390/diagnostics15121499.

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Background/Objectives: This research presents a novel analytical method for breast tumor characterization and tissue classification by leveraging intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) combined with hyperspectral imaging techniques and deep learning. Traditionally, dynamic contrast-enhanced MRI (DCE-MRI) is employed for breast tumor diagnosis, but it involves gadolinium-based contrast agents, which carry potential health risks. IVIM imaging extends conventional diffusion-weighted imaging (DWI) by explicitly separating the signal decay into components representing tr
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12

Stoeck, Christian T., Constantin von Deuster, Martin Genet, David Atkinson, and Sebastian Kozerke. "Second-order motion-compensated spin echo diffusion tensor imaging of the human heart." Magnetic Resonance in Medicine 75, no. 4 (2015): 1669–76. http://dx.doi.org/10.1002/mrm.25784.

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13

Khalique, Zohya, Andrew D. Scott, Pedro F. Ferreira, Sonia Nielles-Vallespin, David N. Firmin, and Dudley J. Pennell. "Diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy: a comparison of motion-compensated spin echo and stimulated echo techniques." Magnetic Resonance Materials in Physics, Biology and Medicine 33, no. 3 (2019): 331–42. http://dx.doi.org/10.1007/s10334-019-00799-3.

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Abstract Objectives Diffusion tensor cardiovascular magnetic resonance (DT-CMR) interrogates myocardial microstructure. Two frequently used in vivo DT-CMR techniques are motion-compensated spin echo (M2-SE) and stimulated echo acquisition mode (STEAM). Whilst M2-SE is strain-insensitive and signal to noise ratio efficient, STEAM has a longer diffusion time and motion compensation is unnecessary. Here we compare STEAM and M2-SE DT-CMR in patients. Materials and methods Biphasic DT-CMR using STEAM and M2-SE, late gadolinium imaging and pre/post gadolinium T1-mapping were performed in a mid-ventr
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14

Gambella, Massimiliano, Federico Zaottini, Stefania Bregante, et al. "Bone Marrow Multiparametric Magnetic Resonance Imaging with Texture Analysis for Follow-up of Advanced Stage Myelofibrosis after Transplantation." Blood 136, Supplement 1 (2020): 3–4. http://dx.doi.org/10.1182/blood-2020-141099.

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Introduction Hematopoietic cell transplantation (HCT) is a potentially curative treatment in myelofibrosis (MF). Nevertheless, in at least one-third of patients, a reliable parameter for disease response is lacking due to the absence of a molecular marker (in triple-negative MF) or the suboptimal sensitivity for CALR and MPL monitoring with routinely used PCR methods. Trephine biopsy provides a limited histological description, as it does not represent the fibrosis and/or blast eradication status of the entire bone marrow. The aim of this study is to identify magnetic resonance imaging (MRI) b
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15

Wallace, Tess E., Kevin Moulin, Jennifer Rodriguez, et al. "Repeatability and reproducibility of accelerated free breathing motion-compensated spin-echo cardiac diffusion tensor imaging." Journal of Cardiovascular Magnetic Resonance 27 (2025): 101397. https://doi.org/10.1016/j.jocmr.2024.101397.

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16

Afacan, Onur, W. Scott Hoge, Tess E. Wallace, Ali Gholipour, Sila Kurugol, and Simon K. Warfield. "Simultaneous Motion and Distortion Correction Using Dual‐Echo Diffusion‐Weighted MRI." Journal of Neuroimaging 30, no. 3 (2020): 276–85. http://dx.doi.org/10.1111/jon.12708.

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17

Führes, Tobit, Marc Saake, Filip Szczepankiewicz, Sebastian Bickelhaupt, Michael Uder, and Frederik Bernd Laun. "Impact of velocity- and acceleration-compensated encodings on signal dropout and black-blood state in diffusion-weighted magnetic resonance liver imaging at clinical TEs." PLOS ONE 18, no. 10 (2023): e0291273. http://dx.doi.org/10.1371/journal.pone.0291273.

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Purpose The study aims to develop easy-to-implement concomitant field-compensated gradient waveforms with varying velocity-weighting (M1) and acceleration-weighting (M2) levels and to evaluate their efficacy in correcting signal dropouts and preserving the black-blood state in liver diffusion-weighted imaging. Additionally, we seek to determine an optimal degree of compensation that minimizes signal dropouts while maintaining blood signal suppression. Methods Numerically optimized gradient waveforms were adapted using a novel method that allows for the simultaneous tuning of M1- and M2-weighti
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18

Luo, Yaqing, Pedro Ferreira, Dudley Pennell, Guang Yang, Sonia Nielles-Vallespin, and Andrew D. Scott. "Flip-back motion compensated spin echo imaging for reduced field of view multi-slice in vivo diffusion tensor cardiovascular magnetic resonance." Journal of Cardiovascular Magnetic Resonance 27 (2025): 101398. https://doi.org/10.1016/j.jocmr.2024.101398.

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19

BITO, Yoshitaka, Koji HIRATA, Toshihiko EBISU, et al. "Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging." Magnetic Resonance in Medical Sciences 14, no. 1 (2015): 43–50. http://dx.doi.org/10.2463/mrms.2014-0024.

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20

Atkinson, David, David A. Porter, Derek L. G. Hill, Fernando Calamante, and Alan Connelly. "Sampling and reconstruction effects due to motion in diffusion-weighted interleaved echo planar imaging." Magnetic Resonance in Medicine 44, no. 1 (2000): 101–9. http://dx.doi.org/10.1002/1522-2594(200007)44:1<101::aid-mrm15>3.0.co;2-s.

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21

Mori, Susumu, and Peter C. M. van Zijl. "A motion correction scheme by twin-echo navigation for diffusion-weighted magnetic resonance imaging with multiple RF echo acquisition." Magnetic Resonance in Medicine 40, no. 4 (1998): 511–16. http://dx.doi.org/10.1002/mrm.1910400403.

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22

Lin, Yuankai, Jianrui Li, Zhiqiang Zhang, et al. "Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/234245.

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Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D∗), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated
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23

Cao, Jianbo, Hee Kwon Song, Hanwen Yang, et al. "Respiratory Motion Mitigation and Repeatability of Two Diffusion-Weighted MRI Methods Applied to a Murine Model of Spontaneous Pancreatic Cancer." Tomography 7, no. 1 (2021): 66–79. http://dx.doi.org/10.3390/tomography7010007.

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Respiratory motion and increased susceptibility effects at high magnetic fields pose challenges for quantitative diffusion-weighted MRI (DWI) of a mouse abdomen on preclinical MRI systems. We demonstrate the first application of radial k-space-sampled (RAD) DWI of a mouse abdomen using a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) on a 4.7 T preclinical scanner equipped with moderate gradient capability. RAD DWI was compared with the echo-planar imaging (EPI)-based DWI method with similar voxel volumes and acquisition times over a wide range of b-values (0.64,
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24

Haneda, Jun, Akifumi Hagiwara, Masaaki Hori, et al. "A Comparison of Techniques for Correcting Eddy-current and Motion-induced Distortions in Diffusion-weighted Echo-planar Images." Magnetic Resonance in Medical Sciences 18, no. 4 (2019): 272–75. http://dx.doi.org/10.2463/mrms.tn.2018-0095.

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25

Dietrich, O., S. Heiland, T. Benner, and K. Sartor. "Reducing motion artefacts in diffusion-weighted MRI of the brain: efficacy of navigator echo correction and pulse triggering." Neuroradiology 42, no. 2 (2000): 85–91. http://dx.doi.org/10.1007/s002340050020.

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26

Gumus, Kazim, Brian Keating, Benedikt A. Poser, et al. "Prevention of motion-induced signal loss in diffusion-weighted echo-planar imaging by dynamic restoration of gradient moments." Magnetic Resonance in Medicine 71, no. 6 (2013): 2006–13. http://dx.doi.org/10.1002/mrm.24857.

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27

Miyoshi, Fuminori, Yuki Shinohara, Atsushi Kambe, et al. "Utility of intravoxel incoherent motion magnetic resonance imaging and arterial spin labeling for recurrent glioma after bevacizumab treatment." Acta Radiologica 59, no. 11 (2018): 1372–79. http://dx.doi.org/10.1177/0284185118759707.

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Background Detecting recurrence of glioma on magnetic resonance imaging (MRI) is getting more and more important, especially after administration of new anti-tumor agent. However, it is still hard to identify. Purpose To examine the utility of intravoxel incoherent motion (IVIM) MRI and arterial spin labeling-cerebral blood flow (ASL-CBF) for recurrent glioma after initiation of bevacizumab (BEV) treatment. Material and Methods Thirteen patients (7 men, 6 women; age range = 41–82 years) with glioma (high grade, n = 11; low grade, n = 2) were enrolled in the study. IVIM parameters including app
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Munoz, Camila, Eunji Lim, Pedro Ferreira, Dudley Pennell, Sonia Nielles-Vallespin, and Andrew Scott. "In vivo Intravoxel Incoherent Motion Imaging (IVIM) in the Human Heart with Phase-cycled Stimulated-echo Diffusion Weighted Imaging." Journal of Cardiovascular Magnetic Resonance 26 (2024): 100176. http://dx.doi.org/10.1016/j.jocmr.2024.100176.

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Garimella, Narayana. "Abstract 479: The role of diffusion in molecular networks: Diffusion coefficients in describing the development of cancer." Cancer Research 82, no. 12_Supplement (2022): 479. http://dx.doi.org/10.1158/1538-7445.am2022-479.

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Abstract To study and forecast the developments of cancers, the molecular networks, compositional fluctuations, diffusion in networks and altogether the biological processes resulting at cellular and intracellular levels, are highly important. Focusing on diffusion coefficients as the translational biomarkers to quantify the nucleation and growth of tumors and cancers has potential advantages. Because, diffusion coefficients act as guiding tools in preventing or treating the cancers and associated adversities. Collectively the biological, pharmacological and toxicological indicators during and
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Wochner, Pamela, Torben Schneider, Jason Stockmann, Jack Lee, and Ralph Sinkus. "Diffusion phase-imaging in anisotropic media using non-linear gradients for diffusion encoding." PLOS ONE 18, no. 3 (2023): e0281332. http://dx.doi.org/10.1371/journal.pone.0281332.

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Diffusion MRI classically uses gradient fields that vary linearly in space to encode the diffusion of water molecules in the signal magnitude by tempering its intensity. In spin ensembles, a presumably equal number of particles move in positive and negative direction, resulting in approximately zero change in net phase. Hence, in classical diffusion weighted MRI with a linear gradient field, the phase does not carry any information as the incoherent motion of the spins only impacts the magnitude of the signal. Conversely, when the linear gradient field is replaced with one that varies quadrati
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Chevallier, Olivier, Nan Zhou, Jian He, Romaric Loffroy, and Yì Xiáng J. Wáng. "Removal of evidential motion-contaminated and poorly fitted image data improves IVIM diffusion MRI parameter scan–rescan reproducibility." Acta Radiologica 59, no. 10 (2018): 1157–67. http://dx.doi.org/10.1177/0284185118756949.

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Background It has been reported that intravoxel incoherent motion (IVIM) diffusion magnetic resonance imaging (MRI) scan–rescan reproducibility is unsatisfactory. Purpose To study IVIM MRI parameter reproducibility for liver parenchyma after the removal of motion-contaminated and/or poorly fitted image data. Material and Methods Eighteen healthy volunteers had liver scans twice in the same session to assess scan–rescan repeatability, and again in another session after an average interval of 13 days to assess reproducibility. Diffusion-weighted images were acquired with a 3-T scanner using resp
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Shen, Nanxi, Lingyun Zhao, Jingjing Jiang, et al. "Intravoxel incoherent motion diffusion-weighted imaging analysis of diffusion and microperfusion in grading gliomas and comparison with arterial spin labeling for evaluation of tumor perfusion." Journal of Magnetic Resonance Imaging 44, no. 3 (2016): 620–32. http://dx.doi.org/10.1002/jmri.25191.

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33

Wáng, Yì Xiáng J., Min Deng, Yáo T. Li, et al. "A Combined Use of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early-Stage Hepatitis-b Fibrotic Livers from Healthy Livers." SLAS TECHNOLOGY: Translating Life Sciences Innovation 23, no. 3 (2017): 259–68. http://dx.doi.org/10.1177/2472630317717049.

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This study investigated a combined use of intravoxel incoherent motion (IVIM) parameters, Dslow ( D), PF ( f), and Dfast ( D*), for liver fibrosis evaluation. Sixteen healthy volunteers (F0) and 33 hepatitis-b patients (stage F1 = 15, stage F2–4 = 18) were included. With a 1.5 T MR scanner and respiration gating, IVIM diffusion-weighted imaging was acquired using a single-shot echo-planar imaging sequence with 10 b values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm2. Signal measurement was performed on right liver parenchyma. With a three-dimensional tool, Dslow, PF, and Dfast valu
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Wang, Chaochao, and Haibo Dong. "Ki-67 labeling index and the grading of cerebral gliomas by using intravoxel incoherent motion diffusion-weighted imaging and three-dimensional arterial spin labeling magnetic resonance imaging." Acta Radiologica 61, no. 8 (2019): 1057–63. http://dx.doi.org/10.1177/0284185119891694.

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Background Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and three-dimensional arterial spin labeling (3D-ASL) have been applied to brain tumors; however, the relationship between their parameters and the Ki-67 labeling index (Ki-67 LI) for the grading of gliomas have yet to be investigated. Purpose The aim of this study is to compare multiple parameters obtained from IVIM-DWI and 3D-ASL with the Ki-67 LI when grading gliomas. Material and Methods Fifty-two patients with pathologically confirmed gliomas had undergone magnetic resonance imaging (MRI), including IVIM-DWI and
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Hales, Patrick W., and Chris A. Clark. "Combined Arterial Spin Labeling and Diffusion-Weighted Imaging for Noninvasive Estimation of Capillary Volume Fraction and Permeability-Surface Product in the Human Brain." Journal of Cerebral Blood Flow & Metabolism 33, no. 1 (2012): 67–75. http://dx.doi.org/10.1038/jcbfm.2012.125.

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A number of two-compartment models have been developed for the analysis of arterial spin labeling (ASL) data, from which both cerebral blood flow ( CBF) and capillary permeability-surface product ( PS) can be estimated. To derive values of PS, the volume fraction of the ASL signal arising from the intravascular space ( vbw) must be known a priori. We examined the use of diffusion-weighted imaging (DWI) and subsequent analysis using the intravoxel incoherent motion model to determine vbw in the human brain. These data were then used in a two-compartment ASL model to estimate PS. Imaging was per
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Lu, Ping, Yan Sha, Hailin Wan, Feng Wang, Guohong Tian, and Wenlin Tang. "Assessment of nonarteritic anterior ischemic optic neuropathy with intravoxel incoherent motion diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging, and 2D navigator-based reacquisition." Journal of Magnetic Resonance Imaging 46, no. 6 (2017): 1760–66. http://dx.doi.org/10.1002/jmri.25760.

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Wang, Kang, Matthew J. Middione, Andreas M. Loening, et al. "Motion-Compensated Multishot Pancreatic Diffusion-Weighted Imaging With Deep Learning–Based Denoising." Investigative Radiology, January 20, 2025. https://doi.org/10.1097/rli.0000000000001148.

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Objectives Pancreatic diffusion-weighted imaging (DWI) has numerous clinical applications, but conventional single-shot methods suffer from off resonance-induced artifacts like distortion and blurring while cardiovascular motion-induced phase inconsistency leads to quantitative errors and signal loss, limiting its utility. Multishot DWI (msDWI) offers reduced image distortion and blurring relative to single-shot methods but increases sensitivity to motion artifacts. Motion-compensated diffusion-encoding gradients (MCGs) reduce motion artifacts and could improve motion robustness of msDWI but c
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Aliotta, Eric, Holden H. Wu, and Daniel B. Ennis. "High-resolution spin-echo Cardiac Diffusion-Weighted MRI with motion compensated Convex Optimized Diffusion Encoding (CODE)." Journal of Cardiovascular Magnetic Resonance 18, S1 (2016). http://dx.doi.org/10.1186/1532-429x-18-s1-p26.

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Lee, Philip K., Xuetong Zhou, and Brian A. Hargreaves. "Diffusion‐prepared imaging with amplitude navigation for correction of motion‐induced signal loss." Magnetic Resonance in Medicine, March 4, 2025. https://doi.org/10.1002/mrm.30484.

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AbstractPurposeDiffusion‐prepared imaging is a flexible alternative to conventional spin‐echo diffusion‐weighted EPI that allows selection of different imaging readouts and k‐space traversals, and permits control of image contrast or image artifacts. We investigate a new signal model and reconstruction for diffusion‐prepared imaging that addresses signal variations caused by motion‐sensitizing diffusion gradients.MethodsA signal model, sampling theory, and reconstruction framework were developed assuming that motion‐induced phases and the measured signals are random variables. The reconstructi
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Chen, Rui, Ruohong Luo, Yongzhou Xu, et al. "Second‐Order Motion‐Compensated Echo‐Planar Cardiac Diffusion‐Weighted MRI: Usefulness of Compressed Sensitivity Encoding." Journal of Magnetic Resonance Imaging, April 8, 2024. http://dx.doi.org/10.1002/jmri.29383.

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BackgroundCardiac diffusion‐weighted imaging (DWI) using second‐order motion‐compensated spin echo (M2C) can provide noninvasive in‐vivo microstructural assessment, but limited by relatively low signal‐to‐noise ratio (SNR). Echo‐planar imaging (EPI) with compressed sensitivity encoding (EPICS) could address these issues.PurposeTo combine M2C DWI and EPCIS (M2C EPICS DWI), and compare image quality for M2C DWI.Study TypeProspective.PopulationTen ex‐vivo hearts, 10 healthy volunteers (females, 5 [50%]; mean ± SD of age, 25 ± 4 years), and 12 patients with diseased hearts (female, 1 [8.3%]; mean
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Dan, Guangyu, Kaibao Sun, Qingfei Luo, and Xiaohong Joe Zhou. "Single‐shot multi‐b‐value (SSMb) diffusion‐weighted MRI using spin echo and stimulated echoes with variable flip angles." NMR in Biomedicine, September 22, 2024. http://dx.doi.org/10.1002/nbm.5261.

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AbstractConventional diffusion‐weighted imaging (DWI) sequences employing a spin echo or stimulated echo sensitize diffusion with a specific b‐value at a fixed diffusion direction and diffusion time (Δ). To compute apparent diffusion coefficient (ADC) and other diffusion parameters, the sequence needs to be repeated multiple times by varying the b‐value and/or gradient direction. In this study, we developed a single‐shot multi‐b‐value (SSMb) diffusion MRI technique, which combines a spin echo and a train of stimulated echoes produced with variable flip angles. The method involves a pair of 90°
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Lee, Philip K., Xuetong Zhou, and Brian A. Hargreaves. "Robust multishot diffusion‐weighted imaging of the abdomen with region‐based shot rejection." Magnetic Resonance in Medicine, April 16, 2024. http://dx.doi.org/10.1002/mrm.30102.

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AbstractPurposeDiffusion‐weighted (DW) imaging provides a useful clinical contrast, but is susceptible to motion‐induced dephasing caused by the application of strong diffusion gradients. Phase navigators are commonly used to resolve shot‐to‐shot motion‐induced phase in multishot reconstructions, but poor phase estimates result in signal dropout and Apparent Diffusion Coefficient (ADC) overestimation. These artifacts are prominent in the abdomen, a region prone to involuntary cardiac and respiratory motion. To improve the robustness of DW imaging in the abdomen, region‐based shot rejection sch
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Afzali, Maryam, Lars Mueller, Sam Coveney, et al. "In vivo diffusion MRI of the human heart using a 300 mT/m gradient system." Magnetic Resonance in Medicine, April 22, 2024. http://dx.doi.org/10.1002/mrm.30118.

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AbstractPurposeThis work reports for the first time on the implementation and application of cardiac diffusion‐weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure.MethodsCardiac diffusion‐weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin‐echo sequence with up to second‐ and third‐order motion compensation ( and ) and , and 1000 (twice the commonly used on clinical scanners). Mean diffusivity (MD), fractiona
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Zhou, Xuetong, Bruce L. Daniel, Brian A. Hargreaves, and Philip K. Lee. "Distortion‐free water‐fat separated diffusion‐weighted imaging using spatiotemporal joint reconstruction." Magnetic Resonance in Medicine, July 25, 2024. http://dx.doi.org/10.1002/mrm.30221.

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AbstractPurposeDiffusion‐weighted imaging (DWI) suffers from geometric distortion and chemical shift artifacts due to the commonly used Echo Planar Imaging (EPI) trajectory. Even with fat suppression in DWI, severe B0 and B1 variations can result in residual fat, which becomes both a source of image artifacts and a confounding factor in diffusion‐weighted contrast in distinguishing benign and malignant tissues. This work presents a method for acquiring distortion‐free diffusion‐weighted images using spatiotemporal acquisition and joint reconstruction. Water‐fat separation is performed by chemi
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Utkur, Mustafa, Liam Timms, Sila Kurugol, and Onur Afacan. "Ultrafast and robust T2 mapping using optimized single‐shot multi‐echo planar imaging with alternating blips." Magnetic Resonance in Medicine, April 28, 2025. https://doi.org/10.1002/mrm.30516.

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AbstractPurposeTo develop a rapid, motion‐robust mapping technique suitable for clinical use across the body, including traditionally challenging, motion‐prone patient populations or body parts.MethodsA novel single‐shot multi‐echo spin‐echo EPI sequence with alternating phase encoding direction on each echo was implemented. This sequence acquires multiple echoes to measure from a single RF excitation. The alternating phase encoding gradient polarity enables the correction of geometric distortions in EPI using post‐processing software. Stimulated echoes were removed by optimizing spoiler gradi
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Zhang, Hongbo, Xiaohai Ma, and Lei Zhao. "Editorial for “Second‐Order Motion‐Compensated Echo‐Planar Cardiac Diffusion‐Weighted MRI: Usefulness of Compressed Sensitivity Encoding”." Journal of Magnetic Resonance Imaging, April 25, 2024. http://dx.doi.org/10.1002/jmri.29410.

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Cao, Xiaozhi, Congyu Liao, Zihan Zhou, et al. "DTI‐MR fingerprinting for rapid high‐resolution whole‐brain T1, T2, proton density, ADC, and fractional anisotropy mapping." Magnetic Resonance in Medicine, November 7, 2023. http://dx.doi.org/10.1002/mrm.29916.

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AbstractPurposeThis study aims to develop a high‐efficiency and high‐resolution 3D imaging approach for simultaneous mapping of multiple key tissue parameters for routine brain imaging, including T1, T2, proton density (PD), ADC, and fractional anisotropy (FA). The proposed method is intended for pushing routine clinical brain imaging from weighted imaging to quantitative imaging and can also be particularly useful for diffusion‐relaxometry studies, which typically suffer from lengthy acquisition time.MethodsTo address challenges associated with diffusion weighting, such as shot‐to‐shot phase
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Sadighi, Mehdi, Danielle Kara, Dingheng Mai, et al. "Cardiac DTI using short‐axis PROPELLER: A feasibility study." Magnetic Resonance in Medicine, February 20, 2024. http://dx.doi.org/10.1002/mrm.30020.

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AbstractPurposeWe aimed to develop a free‐breathing (FB) cardiac DTI (cDTI) method based on short‐axis PROPELLER (SAP) and M2 motion compensated spin‐echo EPI (SAP‐M2‐EPI) to mitigate geometric distortion and eliminate aliasing in acquired diffusion‐weighted (DW) images, particularly in patients with a higher body mass index (BMI).Theory and MethodsThe study involved 10 healthy volunteers whose BMI values fell into specific categories: BMI &lt;25 (4 volunteers), 25&lt; BMI &lt;28 (5 volunteers), and BMI &gt;30 (1 volunteer). We compared DTI parameters, including fractional anisotropy (FA), mea
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Cui, Ying, Yufei Zhao, Xiaohui Chen, et al. "Value of Non‐Contrast‐Enhanced Vessel Wall MR Imaging in Assessing Vascular Invasion of Retroperitoneal Tumors." Journal of Magnetic Resonance Imaging, November 6, 2023. http://dx.doi.org/10.1002/jmri.29120.

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BackgroundDue to their location and growth patterns, retroperitoneal tumors often involve the surrounding blood vessels. Clinical decisions on a proper treatment depend on the information on this condition. Evaluation of blood vessels using non‐contrast‐enhanced vessel wall MRI may provide noninvasive assessment of the extent of tumor invasion to assist clinical decision‐making.PurposeTo investigate the performance and potential of non‐contrast‐enhanced vessel wall MRI in evaluating the degree of vessel wall invasion of retroperitoneal tumors.Study TypeProspective.PopulationThirty‐seven partic
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Basukala, Dibash, Artem Mikheev, Varadan Sevilimedu, et al. "Multisite MRI Intravoxel Incoherent Motion Repeatability and Reproducibility across 3 T Scanners in a Breast Diffusion Phantom: A BReast Intravoxel Incoherent Motion Multisite (BRIMM) Study." Journal of Magnetic Resonance Imaging, September 13, 2023. http://dx.doi.org/10.1002/jmri.29008.

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BackgroundMonoexponential apparent diffusion coefficient (ADC) and biexponential intravoxel incoherent motion (IVIM) analysis of diffusion‐weighted imaging is helpful in the characterization of breast tumors. However, repeatability/reproducibility studies across scanners and across sites are scarce.PurposeTo evaluate the repeatability and reproducibility of ADC and IVIM parameters (tissue diffusivity (Dt), perfusion fraction (Fp) and pseudo‐diffusion (Dp)) within and across sites employing MRI scanners from different vendors utilizing 16‐channel breast array coils in a breast diffusion phantom
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