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Relevant bibliographies by topics / Motor Neuron differentiation / Dissertations / Theses

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Dissertations / Theses on the topic 'Motor Neuron differentiation'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Toli, Diana Eleni. "Directed differentiation and purification of motor neurons from human induced pluripotent stem cells to model Amyotrophic Lateral Sclerosis." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T044/document.

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La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative incurable de l’adulte qui affecte principalement les motoneurones. Les mécanismes conduisant à la mort des motoneurones restent mal connus, notamment du fait de l'hétérogénéité de la maladie et du manque d'accès aux neurones humains affectés. La technologie des cellules souches pluripotentes induites humaines (iPSc) est un outil prometteur pour la modélisation de la SLA, car elle offre la possibilité unique d'obtenir et d’étudier des motoneurones humains.Des clones d’iPSc de deux sujets témoins ont été générés et nous a

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2

Hallgren, Henrik. "Characterization of NeuN expression in the mouse neuronal NSC-34 cell line using RT-qPCR, immunological staining and siRNA-mediated gene suppression." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-389757.

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Background: Acute spinal trauma is followed by a secondary injury that causes additional damage to the tissue. The mouse neuronal hybrid cell line NSC-34 is planned for studies regarding this process, wherefore the cell line needed to be established in the laboratory and a proof-of-concept study needed to be performed. A suitable target gene for this study was Neuronal Nucleus (NeuN), a neuronal marker expressed in nearly all neuronal cells although not yet studied in NSC-34. Aim: The aim of this project was to characterize the expression of NeuN in differentiated and undifferentiated NSC-34 c

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3

Dai, Xizi. "Fiber Scaffolds of Poly (glycerol-dodecanedioate) and its Derivative via Electrospinning for Neural Tissue Engineering." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1852.

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Peripheral nerves have demonstrated the ability to bridge gaps of up to 6 mm. Peripheral Nerve System injury sites beyond this range need autograft or allograft surgery. Central Nerve System cells do not allow spontaneous regeneration due to the intrinsic environmental inhibition. Although stem cell therapy seems to be a promising approach towards nerve repair, it is essential to use the distinct three-dimensional architecture of a cell scaffold with proper biomolecule embedding in order to ensure that the local environment can be controlled well enough for growth and survival. Many approaches

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4

Martinou, Jean-Claude. "Purification de motoneurones embryonnaires : caracterisation de facteurs de survie et de differenciation in vitro." Toulouse 3, 1988. http://www.theses.fr/1988TOU30140.

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Des motoneurons d'embryons de rat (14 jours) ont ete marques de maniere retrograde, apres injection dans les pattes d'un compose liposoluble fluorescents, puis enrichies sur gradient de densite ou purifies a homogeneite avec un tri de cellules. Les motoneurones purifies sont maintenus en survie a long terme sur des monocouches d'astrocytes. Le substratum joue un role important dans leur differenciation, ainsi cultives, les motoneurones lyses presentent une activite choline acetylcholinesterase. Deux facteurs de differenciation qui stimulent l'activite choline-acetylstransferase, sous effet sur

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5

O'Brien, Laura. "Mitochondrial biogenesis and electrical properties of hPSC-derived motor neurons." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3804.

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Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) hold great promise in the fields of drug development and regenerative medicine. If iPSCs reprogrammed from patient cells replicate what is seen in vivo they may be used as a model of disease. A process that is disrupted in many neurodegenerative diseases is mitochondrial biogenesis. One of these diseases is amyotrophic lateral sclerosis (ALS), which is characterized by loss of motor neurons in the brain and spinal cord. Differentiation of hPSCs into motor neurons offers

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6

Lee, Hyojin. "Directed differentiation and functional characterization of embryonic stem cell-derived motoneurons /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1296098331&sid=4&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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7

Sadegh, Cameron. "Directed differentiation of mouse embryonic stem cells into neocortical output neurons." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11064.

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During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons (CFuPN), is the primary output neuron population of the neocortex. CFuPN axons innervate sub-cortical targets including thalamus, striatum, brainstem, and spinal cord.

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8

Podrygajlo, Grzegorz. "Differentiation of human teratocarcinoma cell line into motor neurons: investigation of cellular phenotype in vitro and in transplantation studies." Hannover Bibliothek der Tierärztlichen Hochschule Hannover, 2009. http://d-nb.info/1000125572/34.

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9

Podrygajlo, Grzegorz [Verfasser]. "Differentiation of human teratocarcinoma cell line into motor neurons : investigation of cellular phenotype in vitro and in transplantation studies / Grzegorz Podrygajlo." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2009. http://d-nb.info/1000125572/34.

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10

Chen, J. A. "Cyclin Dx, a novel cell-type specific cyclin identified from an enhanced functional screen, regulates the differentiation of motor neurons in Xenopus." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597520.

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The formation of mesoderm is an important development process of vertebrate embryos, which can be broken down into several steps; mesoderm induction, patterning, morphogenesis and differentiation. Although mesoderm formation in <i>Xenopus</i> has been intensively studied, much remains to be learned about the molecular events responsible for each of these steps. Furthermore, the interplay between mesoderm induction, patterning and morphogenesis remains obscure. Here, I describe an enhanced functional screen in <i>Xenopus</i> designed for large-scale identification of genes controlling mesoderm

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11

Mouilleau, Vincent. "Etude des mécanismes du développement de la moelle épinière humaine par la mise en place de modèles in vitro dérivés de cellules souches pluripotentes humaines." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS407.

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La mise en place des circuits moteurs dépend, au cours du développement, de la spécification de plusieurs milliers de types de motoneurones (MNs) distincts générés à différentes positions le long de l’axe rostro-caudal (R-C) de la moelle épinière. En fonction de leur localisation, ces MNs acquièrent des propriétés particulières telles que la position des corps cellulaires ou encore la spécificité de leurs projections axonales vers leur muscles cible. La diversification des MNs est en correspondance avec différents segments de la moelle épinière : cervical, brachial, thoracique, lombaire et sac

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12

Mazaleyrat, Kilian. "Modélisation de pathologies neuromusculaires par la co-différenciation dirigée de cellules souches pluripotentes induites, en fibres musculaires innervées par des motoneurones." Thesis, Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0127.

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Les cellules souches pluripotentes induites obtenues par reprogrammation des cellules somatiques primaires ont révolutionné les domaines de la biologie cellulaire et de la modélisation des maladies. Cependant, la modélisation des maladies musculaires squelettiques et neuromusculaires humaines a été entravée par un nombre limité de protocoles pour la génération de fibres musculaires matures avec une organisation sarcolemmale. Par co-différenciation simultanée de hiPSC dans les cellules musculaires et les motoneurones, nous avons développé une nouvelle procédure pour générer des fibres musculair

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13

Zanghieri, Marcello. "sEMG-based hand gesture recognition with deep learning." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18112/.

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Hand gesture recognition based on surface electromyographic (sEMG) signals is a promising approach for the development of Human-Machine Interfaces (HMIs) with a natural control, such as intuitive robot interfaces or poly-articulated prostheses. However, real-world applications are limited by reliability problems due to motion artifacts, postural and temporal variability, and sensor re-positioning. This master thesis is the first application of deep learning on the Unibo-INAIL dataset, the first public sEMG dataset exploring the variability between subjects, sessions and arm postures, by colle

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14

Tan, Glenn Christopher. "The Dual Role of Notch Signaling During Motor Neuron Differentiation." Thesis, 2012. https://doi.org/10.7916/D8N01DMB.

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Throughout the developing spinal cord, Olig2+ progenitors in the motor neuron progenitor domain give rise to an impressive array of motor neurons, oligodendrocytes and astrocytes. Motor neurons are further diversified into motor columns and pools based on cell body settling position, general axonal trajectories, and the individual muscles they innervate. Elegant studies have demonstrated that motor neuron columnar and pool diversity, along the rostral-caudal axis of spinal cord, is programmed by extrinsic signals that confer a combinatorial Hox code at each rostral-caudal coordinate. However,

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15

Chiou, Hung-Shiang, and 邱鴻祥. "Stimulation of Purinergic Signaling Pathway Induces SMN Protein Expression and Neuronal Differentiation in Motor-Neuron-Like NSC-34 Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/mtaqpv.

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碩士<br>高雄醫學大學<br>醫學系生理學科碩士班<br>103<br>Abstract Spinal muscular atrophy (SMA) is a genetic neurodegenerative disease. survival of motor neuron (SMN) protein has been found in cell nucleus as well as the neurite and growth cone of developing motor neurons. Nonetheless, it is still not clarified that why SMN deficiency causes neurodegeneration. In addition, accumulating evidence have shown that extracellular purines such as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) act as neurotransmitters to modulate nerve synapse. Purines binds to the purinergic receptor (P2 receptor) such as

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16

Reimer, Michell Mario [Verfasser]. "Motor neuron differentiation in the developing and the regenerating adult spinal cord of zebrafish Danio rerio (Hamilton, 1822) / vorgelegt von Michell Mario Reimer." 2008. http://d-nb.info/992012635/34.

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17

Shin, Soojung. "Induced differentiation of human embryonic stem cells toward motor neurons." 2004. http://purl.galileo.usg.edu/uga%5Fetd/shin%5Fsoojung%5F200412%5Fphd.

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18

Fox, Rebecca M. "Expression profiling reveals key regulators of synaptic specificity and function in the C. elegans motor circuit." Diss., 2006. http://etd.library.vanderbilt.edu/ETD-db/available/etd-11272006-151039/.

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19

Campbell, Richard F. "TRANSCRIPTIONAL REGULATION OF FACTORS REQUIRED FOR THE DIFFERENTIATION OF GABAERGIC MOTOR NEURONS IN THE DEVELOPING VENTRAL NERVE CORD OF CAENORHABDITIS ELEGANS." 2017. http://scholarworks.gsu.edu/biology_diss/173.

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Development of the nervous system is a highly organized process that utilizes genetic mechanisms conserved across the animal kingdom. Components of the nervous system such as inhibitory GABAergic neural networks are common among most multicellular animals. The nematode Caenorhabditis elegans, utilizes similar genetic pathways to that of mice and humans to develop its GABAergic neural networks. These GABAergic neural networks are composed of two types of GABAergic motor neurons: the VD and DD sub-classes. The GABAergic differentiation of both these sub-classes requires the conserved transcripti

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20

Korff, Thomas Jensen Jody L. "Age-related differences in muscular force application differentiating between the influences of growth and maturation of the neuro-motor system /." 2005. http://repositories.lib.utexas.edu/bitstream/handle/2152/1784/korfft99513.pdf.

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21

Korff, Thomas. "Age-related differences in muscular force application: differentiating between the influences of growth and maturation of the neuro-motor system." Thesis, 2005. http://hdl.handle.net/2152/1784.

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