Relevant bibliographies by topics / Motor neurons

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Motor neurons'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Motor neurons"

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Tamarkin, D. A., and R. B. Levine. "Synaptic interactions between a muscle-associated proprioceptor and body wall muscle motor neurons in larval and Adult manduca sexta." Journal of Neurophysiology 76, no. 3 (1996): 1597–610. http://dx.doi.org/10.1152/jn.1996.76.3.1597.

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1. Synaptic remodeling of a proprioceptive circuit during metamorphosis of the insect, Manduca sexta, is described. The stretch receptor organ is a muscle-associated proprioceptor that is innervated by a single sensory neuron. It inserts dorsolaterally in the abdomen in parallel with the intersegmental muscles of each abdominal segment. The synaptic input from the stretch receptor sensory neuron to select abdominal internal (intersegmental) and external muscle motor neurons was characterized in both the larva and adult. 2. In the larva, the sensory neuron provides excitatory synaptic input to
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Liu, Wenshu, J. Franklin Bailey, Visaka Limwongse, and Mark DeSantis. "Scanning Electron Microscopy of neuronal cell bodies isolated from the adult mammalian central nervous system." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 426–27. http://dx.doi.org/10.1017/s0424820100159679.

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Action potentials generated in a motor neuron reflect the summation of synaptic inputs it receives from other neurons. Those synapses occur at points of contiguity between the presynaptic boutons and the surface of the motor neuron. Evidence that the density of axosomalic boutons on motor neurons varies directly with the size of the motor neuronal soma is indirect. Counts of the number of boutons per unit area at the surface of the motor neuron’s cell body using scanning electron microscopy (SEM) would allow an independent, direct assessment of that inference. We describe here procedures for c
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Liu, Zhiping, and Lee J. Martin. "Isolation of Mature Spinal Motor Neurons and Single-cell Analysis Using the Comet Assay of Early Low-level DNA Damage Induced In Vitro and In Vivo." Journal of Histochemistry & Cytochemistry 49, no. 8 (2001): 957–72. http://dx.doi.org/10.1177/002215540104900804.

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We developed an isolation technique for motor neurons from adult rat spinal cord. Spinal cord enlargements were discretely microdissected into ventral horn tissue columns that were trypsin-digested and subjected to differential low-speed centrifugation to fractionate ventral horn cell types. A fraction enriched in α-motor neurons was isolated. Motor neuron enrichment was verified by immunofluorescence for choline acetyltransferase and prelabeling axon projections to skeletal muscle. Adult motor neurons were isolated from naïve rats and were exposed to oxidative agents or were isolated from rat
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Genc, Baris, Oge Gozutok, Nuran Kocak, and P. Hande Ozdinler. "The Timing and Extent of Motor Neuron Vulnerability in ALS Correlates with Accumulation of Misfolded SOD1 Protein in the Cortex and in the Spinal Cord." Cells 9, no. 2 (2020): 502. http://dx.doi.org/10.3390/cells9020502.

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Understanding the cellular and molecular basis of selective vulnerability has been challenging, especially for motor neuron diseases. Developing drugs that improve the health of neurons that display selective vulnerability relies on in vivo cell-based models and quantitative readout measures that translate to patient outcome. We initially developed and characterized UCHL1-eGFP mice, in which motor neurons are labeled with eGFP that is stable and long-lasting. By crossing UCHL1-eGFP to amyotrophic lateral sclerosis (ALS) disease models, we generated ALS mouse models with fluorescently labeled m
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Church, P. J., and P. E. Lloyd. "Activity of multiple identified motor neurons recorded intracellularly during evoked feedinglike motor programs in Aplysia." Journal of Neurophysiology 72, no. 4 (1994): 1794–809. http://dx.doi.org/10.1152/jn.1994.72.4.1794.

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1. The firing patterns of 22 motor neurons were determined by simultaneously recording intracellularly from up to 7 neurons during evoked feedinglike buccal motor programs (BMPs). Intracellular stimulation of cerebral-buccal interneuron 2 (CBI-2) or tactile stimulation of the odontophore were used to elicit BMPs in a reduced preparation. 2. Evoked BMPs were identified as either ingestive-like (iBMP) or egestive-like (eBMP) on the basis of their similarity to those previously recorded in select neurons in freely behaving animals. Neurons were divided into the p-group, r-group, or c-group, on th
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Page, Keri L., Jure Zakotnik, Volker Dürr, and Thomas Matheson. "Motor Control of Aimed Limb Movements in an Insect." Journal of Neurophysiology 99, no. 2 (2008): 484–99. http://dx.doi.org/10.1152/jn.00922.2007.

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Limb movements that are aimed toward tactile stimuli of the body provide a powerful paradigm with which to study the transformation of motor activity into context-dependent action. We relate the activity of excitatory motor neurons of the locust femoro-tibial joint to the consequent kinematics of hind leg movements made during aimed scratching. There is posture-dependence of motor neuron activity, which is stronger in large amplitude (putative fast) than in small (putative slow and intermediate) motor neurons. We relate this posture dependency to biomechanical aspects of the musculo-skeletal s
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Khan, Mudassar N., Pitchaiah Cherukuri, Francesco Negro, et al. "ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control." PLOS Biology 20, no. 12 (2022): e3001923. http://dx.doi.org/10.1371/journal.pbio.3001923.

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The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in mammals is chiefly mediated by gamma motor neurons. The diversification of motor neurons into alpha and gamma types and their respective contributions to movement control have been firmly established in the past 7 decades, while recent studies identified gene expression signatures linked to both motor neuron types. However, the mechanisms that prom
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Quinlan, E. M., K. Gregory, and A. D. Murphy. "An identified glutamatergic interneuron patterns feeding motor activity via both excitation and inhibition." Journal of Neurophysiology 73, no. 3 (1995): 945–56. http://dx.doi.org/10.1152/jn.1995.73.3.945.

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1. Previously we demonstrated that glutamate is an important neurotransmitter in the CNS of Helisoma. Exogenous glutamate applied to the buccal ganglia mimicked both the excitatory and inhibitory effects of subunit 2 (S2) of the tripartite central pattern generator (CPG) on S2 postsynaptic motor neurons. Here we identify buccal interneuron B2 as an S2 interneuron by utilizing a combination of electrophysiology, pharmacology, and intracellular staining. In addition, neurons that were electrophysiologically and morphologically characterized as neuron B2 demonstrated antiglutamate immunoreactivit
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Seki, Soju, Yoshihiro Kitaoka, Sou Kawata, et al. "Characteristics of Sensory Neuron Dysfunction in Amyotrophic Lateral Sclerosis (ALS): Potential for ALS Therapy." Biomedicines 11, no. 11 (2023): 2967. http://dx.doi.org/10.3390/biomedicines11112967.

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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterised by the progressive degeneration of motor neurons, resulting in muscle weakness, paralysis, and, ultimately, death. Presently, no effective treatment for ALS has been established. Although motor neuron dysfunction is a hallmark of ALS, emerging evidence suggests that sensory neurons are also involved in the disease. In clinical research, 30% of patients with ALS had sensory symptoms and abnormal sensory nerve conduction studies in the lower extremities. Peroneal nerve biopsies show histological abnorma
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Bax, Monique, Jessie McKenna, Dzung Do-Ha, et al. "The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation." Cells 8, no. 6 (2019): 581. http://dx.doi.org/10.3390/cells8060581.

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The ubiquitin proteasome system (UPS) plays an important role in regulating numerous cellular processes, and a dysfunctional UPS is thought to contribute to motor neuron disease. Consequently, we sought to map the changing ubiquitome in human iPSCs during their pluripotent stage and following differentiation to motor neurons. Ubiquitinomics analysis identified that spliceosomal and ribosomal proteins were more ubiquitylated in pluripotent stem cells, whilst proteins involved in fatty acid metabolism and the cytoskeleton were specifically ubiquitylated in the motor neurons. The UPS regulator, u
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Dissertations / Theses on the topic "Motor neurons"

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PLETTO, Daniela Rita. "CHARACTERIZATION OF MOLECULAR ISOFORMS AND ROLE OF THE SURVIVAL MOTOR NEURON (SMN) IN MOTOR NEURONS DISEASES." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91238.

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La sclerosi Laterale Amiotrofica (SLA) e l'Atrofia Muscolare Spinale (SMA) sono malattie neurodegenerative caratterizzate dalla perdita progressiva dei motoneuroni. La SMA è generalmente causata da delezione in omozigosi o mutazione del gene SMN, che codifica per una proteina ubiquitaria e multifunzionale, altamente espressa nel midollo spinale. La SLA è una malattia che può essere familiare o sporadica.Il 20% dei casi familiari è causato da una mutazione dominante nel gene SOD1. Inoltre ci sono altri geni coinvolti in questa malattia, tra cui FUS e TDP43. Lo scopo principale della tesi è
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Christou, Yiota Apostolou. "Generation of motor neurons from embryonic stem cells : application in studies of the motor neuron disease mechanism." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505426.

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Embryonic stem cells are pluripotent cells with the potential to differentiate into any cell type in the presence of appropriate stimulatory factors and environmental cues. Their broad developmental potential has led to the proposal that in the future, the use of human embryonic stem cells or their differentiated progeny may be beneficial in regenerative medicine. In particular, a current goal in the field of clinical neurology is to use stem cells in cell-based therapies for motor neuron disease (MND) or amyotrophic lateral ~clerosis. MND is a progressive neurodegenerative disease that specif
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Shaw, Ivan Ting-kun. "Cell death in motor neurons, two complementary models." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0028/NQ50259.pdf.

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Shaw, Ivan Ting-kun 1966. "Cell death in motor neurons : two complementary models." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35486.

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Target-dependent cell death is an important embryogenic mechanism for regulating and sculpting the developing motor system. Efficient characterization of apoptosis has been more difficult in the nervous system than in other systems due to the use of several different primary culture systems as well as with heterogeneity of neuronal cell populations. We have developed a simple in vitro model of apoptosis with the motor neuron hybrid NSC34, a cell line which expresses much of the motor neuron phenotype (Cashman et al. 1992). Serum-deprived NSC 34 cells in bulk culture undergo cell death, likely
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Stephens, Benjamin. "Pathology of spinal interneurons in motor neuron disease." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251759.

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Taylor, David M. 1977 Nov 23. "Understanding the regulation of molecular chaperones in motor neurons." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111857.

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Cells are constantly challenged by acute and chronic stresses that must be counteracted by upregulation of protective pathways. The premise of this thesis is that motor neurons have an impaired ability to trigger these protective mechanisms, which may contribute to their preferential vulnerability in the neurodegenerative disease, amyotrophic lateral sclerosis (ALS). The first objective was to study the involvement of metallochaperones in motor neuronal stress response, including their potential for rescuing motor neurons from toxicity conferred by a mutant Cu/Zn-superoxide dismutase (SOD1G93A
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Deinhardt, Katrin. "The endocytic pathway of tetanus neurotoxin in motor neurons." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428573.

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Murtha, Matthew J. III. "Transcriptional Programming of Spinal Motor Neurons from Stem Cells." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1261416295.

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Wertz, Mary Helene. "Aberrant microRNA Expression in Spinal Muscular Atrophy Motor Neurons." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17464519.

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Spinal Muscular Atrophy (SMA) is a devastating autosomal-recessive pediatric neurodegenerative disease characterized by loss of spinal motor neurons. It is caused by mutation in the survival of motor neuron 1, SMN1, gene and leads to loss of function of the full-length SMN protein. SMN has a number of functions related to RNA processing in neurons, including RNA trafficking in neurites, and RNA splicing and snRNP biogenesis in the nucleus. While previous work has focused on the alternative splicing and expression of traditional mRNAs, our lab has focused on the contribution of another RNA spec
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Nakamizo, Tomoki. "Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons." Kyoto University, 2003. http://hdl.handle.net/2433/148692.

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Books on the topic "Motor neurons"

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G, Stein Paul S., ed. Neurons, networks, and motor behavior. MIT Press, 1997.

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Anthony, Taylor, Gladden M. H. 1940-, and Durbaba Rade, eds. Alpha and gamma motor systems. Plenum Press, 1995.

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D, Binder Marc, and Mendell Lorne M, eds. The Segmental motor system. Oxford University Press, 1990.

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M, Cochrane George, ed. The Management of motor neurone disease. Churchill Livingstone, 1987.

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Roger, Lemon, ed. Corticospinal function and voluntary movement. Clarendon Press, 1993.

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Roger, Lemon, ed. Corticospinal function and voluntary movement. Oxford University Press, 1995.

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Jean, Requin, Stelmach George E, North Atlantic Treaty Organization. Scientific Affairs Division., and NATO Advanced Study Institute on Tutorials in Motor Neuroscience (1990 : Calcatoggio, France), eds. Tutorials in motor neuroscience. Kluwer Academic Publishers, 1991.

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Mendelsohn, Alana Irene. Specifying neurons and circuits for limb motor control. [publisher not identified], 2016.

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Baek, Myungin. Development of leg motor neurons in drosophila melanogaster. [publisher not identified], 2011.

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Talbot, Kevin. Motor neuron disease. Oxford University Press, 2008.

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Book chapters on the topic "Motor neurons"

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Hangay, George, Susan V. Gruner, F. W. Howard, et al. "Motor Neurons." In Encyclopedia of Entomology. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_4707.

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Guiloff, R. J. "Clinical Pharmacology of Motor Neurons." In Motor Neuron Disease. Springer London, 1995. http://dx.doi.org/10.1007/978-1-4471-1871-8_15.

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Roberts, P. A. "Motor Systems — Lower Motor Neurons and Pyramidal System." In Oklahoma Notes. Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2902-5_5.

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Roberts, P. A. "Motor Systems — Lower Motor Neurons and Pyramidal System." In Oklahoma Notes. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-0395-4_5.

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Yarom, Y. "Oscillatory Behavior of Olivary Neurons." In The Olivocerebellar System in Motor Control. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73920-0_20.

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Pfaff, S. L., T. Yamada, T. Edlund, and T. M. Jessell. "Induction and Differentiation of Motor Neurons." In Neural Cell Specification. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1929-4_9.

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Conradi, S. "Functional Implications of Structure and Synaptology of Motor Neurons in Motor Neuron Disease." In Advances in Applied Neurological Sciences. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71540-2_10.

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Barman, S. M. "Descending Projections of Hypothalamic Sympathoexcitatory Neurons in the Cat." In Cardiorespiratory and Motor Coordination. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-75507-1_12.

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Cleland, C. L., and J. A. Hoffer. "Activity of Ventral Spinocerebellar Tract Neurons Chronically Recorded in the Spinal Cord of Awake, Freely Moving Cats." In Motor Control. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4615-7508-5_27.

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Lamontagne, Angélique, and Florence Gaunet. "Social Functions of Mirror Neurons, Motor Resonance and Motor Contagion." In Revealing Behavioural Synchronization in Humans and Other Animals. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-48449-0_5.

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Conference papers on the topic "Motor neurons"

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Yanguas, Javier, Pablo Laguna, and Jaime Ibanez. "Motor Neuron synchronization reduces extraction capacity of common synaptic input." In 2024 13th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO). IEEE, 2024. http://dx.doi.org/10.1109/esgco63003.2024.10766982.

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Ball, John M., Clarence C. Franklin, David J. Schulz, and Satish S. Nair. "Co-Regulation of Calcium and Delayed Rectifier Currents Maintains Neuronal Output in a Model of a Crustacean Cardiac Motor Neuron." In ASME 2008 Dynamic Systems and Control Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/dscc2008-2299.

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Homeostatic processes are widespread throughout all living systems, and the nervous system is no exception. Individual neurons as well as neuronal networks must maintain levels of excitability and connectivity to ensure that consistent functional output is achieved. Possible mechanisms for maintaining functional output using co-regulation of channel conductances is studied for a motor neuron, using a computational model. The results are both consistent with and extend the biological observations.
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Pitta, Marina Galdino da Rocha, Jordy Silva de Carvalho, Luzilene Pereira de Lima, and Ivan da Rocha Pitta. "iPSC therapies applied to rehabilitation in parkinson’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.022.

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Background: Parkinson’s disease (PD) is a neurological disorder that affects movement, mainly due to damage and degeneration of the nigrostriatal dopaminergic pathway. The diagnosis is made through a clinical neurological analysis where motor characteristics are considered. There is still no cure, and treatment strategies are focused on symptoms control. Cell replacement therapies emerge as an alternative. Objective: This review focused on current techniques of induced pluripotent stem cells (iPSCs). Methods: The search terms used were: “Parkinson’s Disease”, “Stem cells” and “iPSC”. Open arti
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Nicoletti, Martina, Alessandro Loppini, Letizia Chiodo, Viola Folli, Giancarlo Ruocco, and Simonetta Filippi. "Mathematical modeling of the Caenorhabditis elegans RMD motor neurons." In 2020 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO). IEEE, 2020. http://dx.doi.org/10.1109/esgco49734.2020.9158182.

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Vieira, Marina Duarte Gama, Anna Letícia Siqueira de Medeiros, Narayna Suellen Santos da Silva, and Edlene Lima Ribeiro. "Dysphagia in patients with amyotrophic lateral sclerosis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.398.

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Background: Amyotrophic lateral sclerosis is a rare neurodegenerative disease that acts on the upper and lower motor neurons, causing muscle weakness.¹²³Dysphagia occurs due to malfunction of the swallowing mechanisms and generates functional problems.⁴⁵⁶ Objectives: Describe the pathophysiology of dysphagia and discuss strategies for symptom relief. Design and setting: Systematic review, Faculdade Integrada Tiradentes, Jaboatão dos Guararapes - PE. Methods: Systematic review of 10 articles from the last years. Results: Dysarthria and dysphagia are common signs of upper motor neuron involvemen
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Elói, Daniel Vinicius, Daniel Lopes Marques de Araújo, Gabriela Fonseca Marçal, Luana Soares Vargas, Matheus Garcia Ribeiro, and Nicollas Nunes Rabelo. "Canabinoids as a therapeutic alternative in refractory epilepsy." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.554.

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Introduction: Epilepsy is characterized by abnormal electrical discharges in the brain that generate neuronal hyperexcitability and hypersynchrony. In the last years, pharmacological strategies have been efficient in the control of epileptic seizures of approximately 80% of patients, however, there are still refractory cases. Objective: To elucidate new forms of epilepsy treatment with cannabinoids. Design: Systematic Review performed at Centro Universitário Atenas – Paracatu – Minas Gerais. Methods: Literature review performed in the SciELO and PubMed databases, with the following terms: epil
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Gonçalo, Ana Clara Mota, and Kaline dos Santos Kishishita Castro. "Treatment and main complications of Amyotrophic Lateral Sclerosis: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.520.

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Background: Greek, the word sklerosis means hardening. In medicine, the term sclerosis refers to the stiffening of body tissues - scars. These scars (sclerosis), when located in motor neurons, are signs of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that affects neurons located in the primary motor cortex, brain stem, spinal cord and pyramidal tract. ALS has no cure and its treatment options are currently limited. Objectives: Review on the major complications of ALS, as well as the therapeutic methods for its treatment. Methods: Study conducted trough articles found on The
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Wang, Ruixue, Jiawei Han, Wang Xi, et al. "Calcium Activation of Parvalbumin Neurons Induced by Electrical Motor Cortex Stimulation." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871749.

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Chae, Soyoung, Taehyung Kim, Sung-Phil Kim, Seong-Min Kim, and Jeong-Woo Sohn. "Sensory and Motor Information in Primary Motor Cortical Neurons During Arm Reaching To a Moving Target." In 2020 8th International Winter Conference on Brain-Computer Interface (BCI). IEEE, 2020. http://dx.doi.org/10.1109/bci48061.2020.9061640.

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Sanggyun Kim, K. Takahashi, N. G. Hatsopoulos, and T. P. Coleman. "Information transfer between neurons in the motor cortex triggered by visual cues." In 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011. http://dx.doi.org/10.1109/iembs.2011.6091697.

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Reports on the topic "Motor neurons"

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Andrades, Oscar, David Ulloa, Dario Martinez, et al. Effect of the manipulation of the variables that configure the stimulus of strength training on motor symptoms in people with Parkinson's disease: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.11.0079.

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Review question / Objective: To analyze the evidence on studies that have manipulated the variables that make up the strength training stimulus and its effects on motor symptoms in people with Parkinson's disease. Condition being studied: Parkinson's is a multisystemic neurodegenerative disease that affects the central nervous system and is caused by a loss of dopaminergic neurons in the compact part of the substantia nigra of the basal ganglia of the midbrain. People with Parkinson's disease (PEP) have non-motor and motor clinical symptoms. Classic motor symptoms are rest tremor, joint stiffn
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Wang, Xiao, Hong Shen, Yujie Liang, Yixin Wang, Meiqi Zhang, and Hongtao Ma. Effectiveness of Tango Intervention on Motor Symptoms in Patients with Parkinson's Disease: A Protocol for Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0009.

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Review question / Objective: Parkinson's disease (PD) is a degenerative neurological disease caused by the loss of dopaminergic neurons in the pars compacta of the substantia nigra of the brain, resulting in lesions in the basal ganglia. The main motor symptoms of PD include resting tremor, rigidity, akinesia or bradykinesia and postural instability. As an exercise intervention based on musical accompaniment, tango dance has shown positive effects on the rehabilitation of motor symptoms in PD patients in recently. In this study, we systematically reviewed the efficacy of tango intervention in
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Zhu, Qiaochu, Jin Zhou, Hai Huang, et al. Risk factors associated with amyotrophic lateral sclerosis: a protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.9.0118.

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Review question / Objective: To identify and list the risk factors associated with the onset and progression of ALS. Condition being studied: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting the upper and lower motor neurons in the spinal bulb, cerebral cortex, and spinal cord. The clinical processing symptoms accompany muscle atrophy, fasciculation, and fatigue of limbs, which can lead to general paralysis and death from respiratory failure within 3-5 years after the onset of this disease. Though the pathogenesis of ALS is still unclear, exploring the associations
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Singh, Ruchi, Akhiya Nail, and Nirendra Kumar Rai. Effectiveness of Vitamin B12 Supplementation on cognitive, motor & mood instability of Parkinson’s disease patients on levodopa treatment :A Systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.2.0066.

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Review question / Objective: The treatment of choice for patients of Parkinson's disease is levodopa. However, levodopa has been suggested to decrease Vit B12 level in these patients. Thus, the research question for this systematic review is whether vit B 12 supplementation in Parkinson's disease(PD) patients on treatment with levodopa improves vit B12 level effecting the Cognition, Motor functions and Mood instability among them in comparison to PD patients on levodopa treatment who are not supplemented with Vit B12. Condition being studied: Parkinson disease is the progressive degeneration o
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Zhang, Yu, Chaoliang Sun, Hengxi Xu, et al. Connectivity-Based Subtyping of De Novo Parkinson Disease: Biomarkers, Medication Effects and Longitudinal Progression. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.10.04.

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Parkinson's disease (PD) is characterized by divergent clinical symptoms and prognosis, suggesting the presence of distinct subtypes. Identifying these subtypes is crucial for understanding the underlying pathophysiology, predicting disease progression, and developing personalized treatments. In this study, we propose a connectivity-based subtyping approach, which measures each patient's deviation from the reference structural covariance networks established in healthy controls. Using data from the Parkinson's Progression Markers Initiative, we identified two distinct subtypes of de novo PD pa
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Santos, Ana Lúcia Yaeko da Silva, Deyse Mayara Rodrigues Caron, Livia Shirahige, and Abrahão Fontes Baptista. Alterations in Corticomotor Excitability in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.5.0078.

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Review question / Objective: To systematically evaluate the utility of TMS to follow up on ALS patients using neurophysiological metrics and to quantify corticomotor excitability compared to sham controls or other neuromuscular diseases. Condition being studied: Amyotrophic Lateral Sclerosis (ALS) is the third most common neurodegenerative disease (BRUNET et al., 2020). The condition is characterized by progressive muscle atrophy due to upper and lower motor neuron death (GOETZ, 2000).
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Svendsen, Clive, and Genevieve Gowing. Muscle-Derived GDNF: A Gene Therapeutic Approach for Preserving Motor Neuron Function in ALS. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada621394.

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ji, yuqin, hao tian, qiang ye, zhuoyan ye, and zeyu zheng. Effectiveness of exercise intervention on improving fundamental motor skills in children with autism spectrum disorder: A systematic review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.12.0013.

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Review question / Objective: This systematic review and meta-analysis aimed to synthesize available randomized controlled trial studies concerning the effects of exercise interventions on fundamental motor skills in children with autism spectrum disorder. Condition being studied: Autism Spectrum Disorder (ASD) is a complicated and highly prevalent neuro-developmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors. The CDC reported that the prevalence of ASD was estimated to be 1 in 59 in the United States by 2020. Along with typical s
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Rothstein, Jeffrey D. Anti-Excitotoxic and Antioxidant TGF-Beta Family Neurotrophic Factors: In Vitro Screening Models of Motor Neuron Degeneration. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada405360.

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Performing motor and sensory neuronal conduction studies in adult humans. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1990. http://dx.doi.org/10.26616/nioshpub90113.

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