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Dissertations / Theses on the topic 'Motorneurone'

Author: Grafiati

Published: 16 November 2024

Last updated: 31 July 2025

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1

Esmaeili, Behrooz. "The C.elegans even-skipped homologue vab-7 controls DB motorneurone fate." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621089.

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2

Pinkernelle, Josephine [Verfasser], and Gerburg [Akademischer Betreuer] Keilhoff. "Etablierung eines in vitro-Modells zur Untersuchung der Regeneration spinaler Motorneurone und ihrer Axone nach Axotomie und Neurodegeneration / Josephine Pinkernelle. Betreuer: Gerburg Keilhoff." Magdeburg : Universitätsbibliothek, 2015. http://d-nb.info/1070276979/34.

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3

Draper, Christiana S. I. "ALS-induced Excitability Changes in Individual Motorneurons and the Spinal Motorneuron Network in SOD1-G93A Mice at Symptom Onset." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1621064515386592.

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4

Hancox, Julian C. "Non-linear membrane properties of insect motorneurones." Thesis, University of St Andrews, 1991. http://hdl.handle.net/10023/15029.

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1. Electrical characteristics of the cell body of an identified motoneurone, the 'fast' coxal depressor motoneurone (Df), from the cockroach (Periplaneta americana) have been studied under current- and voltage-clamp. 2. In response to low magnitude, relatively long duration depolarising current pulses, Df could generate plateau potentials, regenerative events which often far outlived the duration of the applied depolarisation. 3. Plateau potentials constitute an inherent property of the neurone because they could be evoked in somata that had been surgically isolated from other parts of the neu

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5

Uhler, Jennifer Pamela. "The development of dendritic arbors in Drosophila motorneurons." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621930.

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6

Blair, Alex B. "Nervous System Remodeling in Drosophila: The fate of larval motorneurons." Miami University Honors Theses / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1272045959.

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7

Mauss, Alex Stefan. "Development and patterning of motorneuron dendrites in the Drosophila embryo." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611196.

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8

Clerc, Zoé. "Identification des mécanismes moléculaires de neuroprotection modulés par l’activité dans deux maladies du motoneurone." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5087.

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La sclérose latérale amyotrophique (SLA) et l'amyotrophie spinale (SMA) sont deux maladies du motoneurone (MN) se caractérisant par une dénervation musculaire progressive, pouvant être fatale par insuffisance respiratoire. Dans la SLA, les MN rapides (MNr) sont principalement affectés, tandis que dans la SMA, les MNr et les MN lents (MNl) dégénèrent. Le laboratoire a montré que soumettre des modèles murins adultes de la SLA (B6SJL-Tg(SOD1-G93A)1Gur/J) et de la SMA de type 3 (FVB/NRj-SmnDelta7/Delta7,huSMN2+/+) à un exercice de nage, activant les MNr, induisait une neuroprotection spécifique de

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9

Zee, Michele Chi-Wai. "Steroid hormones and cell death : analysis of motorneuron and muscle fates during insect metamorphosis /." view abstract or download file of text, 2004. http://wwwlib.umi.com/cr/uoregon/fullcit?p3136456.

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Thesis (Ph. D.)--University of Oregon, 2004.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 99-113). Also available for download via the World Wide Web; free to University of Oregon users.

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10

Sánchez-Alvarez, Leticia. "Planar Cell Polarity Genes prkl-1 and dsh-1 Polarize C. Elegans Motorneurons during Organogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23513.

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The correct polarity of a neuron underlies its ability to integrate precise circuitries in the nervous system. The goal of my thesis was to investigate the pathways that establish and maintain neuron polarity/orientation in vivo. To accomplish this, I used bipolar VC4/5 motor neurons, which innervate the C. elegans egg-laying musculature, as a model system. Vulval proximal VC4/5 neurons extend axons in the left-right (LR) orientation, around the vulva; whereas vulval distal VC1-3,6 neurons extend axons along the anterior-posterior (AP) axis. A previous study showed that vang-1, a core planar c

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11

James, Rebecca E. "Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364994680.

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12

Lebossé, Marie. "Rôle de la signalisation ErbB/Neurégulines dans la propagation de PEA3 dans les motoneurones de la moelle épinière." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22043.

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Les signaux environnementaux ont une grande influence sur le devenir de certaines populations de motoneurones. J'étudie la population qui exprime le facteur de transcription PEA3, située au niveau brachial, caractérisée et spécifiée par ce facteur, et qui innerve les muscles dorsaux des membres (Livet et al., 2002 ; Vrieseling et al., 2006). Cette population représente un des exemples les mieux compris de l'acquisition d'une identité neuronale par des signaux provenant du muscle cible. Au cours du développement, l'expression de PEA3 se met en place de manière séquentielle. PEA3 est d'abord exp

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13

CANZI, LAURA. "Human stem cells for the treatment of motorneuron diseases: regenerative potential, translatability and development of new biotechnologies. Cellule staminali umane per la cura delle malattie degenerative del motoneurone." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/19217.

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Stem cell therapy is considered one of the most promising approaches against different neurodegenerative disorders, including Amyotorophic Lateral Sclerosis (ALS). The evidence that the systemic injection of human cord blood mononuclear cells (HuCB-MNC) was able to reduce the clinical outcomes and increase the lifespan in a murine model of fALS1, the SOD1G93A mouse, even if localized far from affected motor neurons, opens the way for new possible candidates and alternative ways of administration. Here the effect of human skeletal muscle-derived stem cell (SkmSCs) was investigated by single adm

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14

Schizas, Nikos. "Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers." Doctoral thesis, Uppsala universitet, Ortopedi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251477.

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The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. Regulation of these pathways using immunomodulatory and neuroprotective substances potentially protects the injured spinal cord from further damage. We also developed and studied resorbable biomaterials to be used as carriers for potential neuroprotectants to the injured spinal cord. We used transversal spinal cord slice cultures (SCSCs) derived from postnatal mice as a model. S

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15

Kotaich, Farah. "Neurofilaments in health and Charcot-Marie-Tooth Disease." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10352.

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Les neurofilaments (NFs) sont le constituant le plus stable et le plus abondant des neurones matures. S'interconnectant avec les filaments d'actine et les microtubules, ils constituent le cytosquelette neuronal. Causes génétiques de la maladie de Parkinson, de la sclérose latérale amyotrophique (SLA) et des maladies de Charcot-Marie-Tooth (CMT), les NFs s’agrègent de façon anormale et précoce dans de la plupart des maladies neurodégénératives chez l'homme. Présentant une prévalence de 1/2500 personnes, les CMTs sont reconnues comme les maladies neurodégénératives les plus courantes du système

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16

Carina, Engström, Ludvig Fogelström, and Granbom Julia. "ALS-En livsförändring i vardagen : -En litteraturöversikt." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för omvårdnad, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-39580.

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Syfte: Att beskriva närståendes upplevelser av att leva med en person med ALS. Metod: En litteraturöversikt med kvalitativ metod och en induktiv ansats. Resultat: Sjukdomen ALS är ovanlig och de som drabbas av den är i stort behov av omvårdnad. Närstående till en anhörig som har fått diagnosen ALS, upplever att vårdpersonalen har kunskapsbrist angående sjukdomen och vårdandet. De upplever bristande information om sjukdomens förlopp. Egentiden tas ifrån dem, sådant som förr togs förgivet läggs istället åt sidan, då all fokus ligger på den anhöriges omvårdnad. Slutsats: Närstående väljer ofta at

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17

Dachs, i. Cabanas Elisabet. "Caracterització fenotípica i assaig terapèutic en models murins transgènics d'atròfia muscular espinal." Doctoral thesis, Universitat de Lleida, 2012. http://hdl.handle.net/10803/83624.

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L’atròfia muscular espinal (AME) és una malaltia d’origen genètic que afecta, majoritàriament a la població infantil. La malaltia cursa amb una mort de les motoneurones  i atròfia muscular. El gen implicat és el survival motor neuron (SMN) que està delecionat en un 95% dels casos. El nostre estudi està dividit en dues parts: 1- l’aprofundiment de les alteracions musculars en dos models animals murins transgènics que pateixen les formes més greus d’AME (Tipus 1-2) i 2- estudi dels possibles efectes terapèutics del liti en un d’aquests models d’AME. S’ha trobat alteracions greus en les unions n

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18

Wilmet, Baptiste. "Analyses des dysfonctions neuronales d’un modèle murin de Paraplégie Spastique Héréditaire." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEP045.

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Les Paraplégies Spastiques Héréditaires sont un groupe de maladies du motoneurone caractérisées par une dégénérescence de l’axe corticospinal menant à la spasticité et une paralysie progressive des membres parfois associés à des troubles cognitifs. Des mutations dans le gène SPG11 codant pour la Spatacsine sont la majeure cause de ces formes complexes de HSP. Pour mieux comprendre les mécanismes responsables de la pathologie liée à SPG11, notre équipe a généré un modèle de souris Knock-out pour ce gène, mimant les déficits cognitifs et moteurs observés chez les patients, corrélés à des altérat

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19

Nanadoumgar, Blandine. "Etude des altérations du métabolisme induites par le glutamate dans un modèle in vitro de la sclérose latérale amyotrophique (SLA) par une approche métabolomique." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3804/document.

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La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative caractérisée par une perte sélective des motoneurones et impliquant les effets neurotoxiques des astrocytes. Le but de ce travail est d’explorer les altérations du métabolisme dans les astrocytes induites par des conditions associées à la SLA. Nous avons dans un premier temps mis en place une méthodologie d’analyse spectrométrique (résonance magnétique nucléaire et spectrométries de masse) du métabolome cellulaire. Ensuite, nous avons invalidé les cellules NSC-34 comme modèle in vitro d’étude de l’excitotoxicité induite

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20

Fernandes, Ana Miguel. "Dynamic regulation of co-transcriptional processes during neuronal maturation." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21603.

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Koordinierte Phosphorylierung der C-terminale Domäne von RNA Polymerase II (RNAPII) ist essentiell für eine effiziente Kupplung von naszierender RNA Synthese und co-transkriptionalem RNA Prozessierens. Zirkuläre RNAs (circRNAs) sind eine neue Klasse von RNA Molekülen mit hoher Prävalenz in neuronalen Zelltypen. Die Biogenese von circRNAs ist noch ungeklärt, insbesondere die Frage warum das Intron upstream der circRNA während der Transkription des circRNA Exons zurückbehalten wird um Rück-Spleißen zu ermöglichen. Verschiede Belege suggerieren, dass unzulängliche Rekrutierung des Spleiceosoms zu

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21

Herholz, David. "Profiling the inherent vulnerability of motor neuron subtypes." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-AE3F-7.

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22

Chuang, Yen-Ju, and 莊雁茹. "The Study of the Apoptotic Spinal Motorneuron in Type I Spinal Muscular Atrophy Mice." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/17815001989302076870.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>93<br>Childhood spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder, characterized by degeneration of the anterior horn cells of the spinal cord and by symmetrical proximal muscle weakness and atrophy. Three forms of SMA have been recognized, based on varying clinical severity. The survival motor neuron (SMN) gene is present in humans in a telomeric copy, SMN1, and several centromeric copies, SMN2. Homozygous mutation of SMN1 is associated with SMA. We produced mouse lines deficient for mouse Smn and transgenic mouse lines that expressed h

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23

"Reflex motorneuron excitability of the musculocutaneous nerve in the biceps brachii muscle after upper cervical or cervicothoracic spinal manipulative therapy." Thesis, 2009. http://hdl.handle.net/10210/2671.

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24

Larsen, DeLaine D. "The genetic regulation of sex-specific motorneurons by the doublesex gene in Drosophila melanogaster and the genetic characterization of an interaction with the sex determination hierarchy." Thesis, 1998. http://hdl.handle.net/1957/33315.

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The remodeling of the central nervous system (CNS) during metamorphosis in Drosophila melanogaster is a prime model system in which to study the genetic control of the sexual dimorphisms in the abdominal ganglion of the CNS. I have been using a P[tau-lacZ] enhancer trap line, 4.078, to label a segmentally repeated subset of abdominal motorneurons in order to assess the function of the sex determination hierarchy in controlling sex-specific development of the adult nervous system. In both the male and female larva there are 8 sets of these labeled abdominal motorneurons but only six sets in mal

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25

Rogers, Mandy. "The effect of C5 and C6 spinal manipulative therapy on the alpha motorneuron excitability of the musculocutaneous nerve in the biceps brachii muscle measured using EMG." Thesis, 2008. http://hdl.handle.net/10210/1141.

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M. Tech. Chiro.<br>The purpose of this study was to determine the effect that C5 and C6 spinal manipulative therapy had on alpha motorneuron excitability of the musculocutaneous nerve in the biceps brachii muscle. Readings were recorded using Electromyography (EMG). Eighty asymptomatic subjects participated in this study. The subjects selected had to be between 18 and 35 years of age, having experienced no cervical pain, discomfort or pathology. The subjects had to present with a C5 or C6 joint motion restriction based on motion and static palpation. Patients were selected based on their respo

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26

Schramm, Emilien. "Caractérisation de modèles Alzheimer de C. elegans transgéniques, exprimant la protéine Tau humaine dans leurs motoneurones GABAergiques." Thesis, 2020. http://hdl.handle.net/1866/24532.

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La maladie d’Alzheimer est une maladie neurodégénérative déterminée par deux caractéristiques : les plaques extracellulaires composées d’amyloïde-β et l’accumulation intracellulaire de tau hyperphosphorylée, appelée enchevêtrements neurofibrillaires. Malgré le nombre important d’études, la nature de la toxicité des espèces tau hyperphosphorylée et hypophosphorylée reste mal connue. Notre projet de recherche vise à caractériser quel état de phosphorylation de la tau contribue le plus à la toxicité neuronale ainsi que d’identifier les mécanismes sous-jacents. Pour répondre à ces objectifs, nous

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27

Lin, Wen, and 林文. "Part II：Differential Regulation of Fibronectin Fibrillogenesis by Protein Kinase A and C Part II：Modulation of Protein kinase A Activity in Synaptic Transmission by Matrix Proteins at developing Motorneurons." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/24067439028104716529.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>88<br>Part I： 1.The assembly of fibronectin matrix is a key event in regulating cell adhesion, migration, and differentiation. The signal transduction pathway that regulates fibronectin assembly is still unclear. To elucidate the regulatory role of protein kinase in the formation of fibronectin matrix, we quantitatively examined the fibronectin assembly by fibroblast in Xenopus cell cultures using fluorescent immunocytochemistry. 2.Soluble form of bovine fibronectin was bath-applied to the cultures. Fibroblast changed the soluble form of fibronec

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28

Seyed, Asli Naisana. "The role of microRNA miR-196 in HOX dependant maturation of lumbar motor neurons." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-B648-1.

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