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Relevant bibliographies by topics / Mouse brain development / Dissertations / Theses

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Dissertations / Theses on the topic 'Mouse brain development'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Smith, Maria Civita. "MAPPING ASTROCYTE DEVELOPMENT IN THE DORSAL CORTEX OF THE MOUSE BRAIN." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1373039738.

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2

Espeso, Gil Sergio 1985. "The mouse cortex regulome. Effects of environmental enrichment on postnatal brain development." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/552941.

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El reguloma està constituït per un sistema complex de factors que controlen el fenotip molecular de la cèl·lula, que al seu torn està influenciada pel medi ambient. Qualsevol pertorbació pot desencadenar canvis que poden implicar una regulació disfuncional. El cervell integra constantment una quantitat considerable d’informació motora, sensorial i cognitiva. Aquesta integració és particularment important en el desenvolupament postnatal, en què el cervell ha d'establir els compromisos moleculars necessaris per adaptar-se a un entorn canviant. L'objectiu d'aquest estudi és investigar com els fac

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3

Phillips, Marnie A. (Marnie Ann). "Eye-opening and control of visual synapse development in the mouse superior colliculus." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39005.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 2007.<br>"June 2007."<br>Includes bibliographical references.<br>The mammalian superior colliculus (SC) coordinates visual, somatosensory, and auditory stimuli to guide animal behavior. The superficial layers (sSC) receive visual information via two major afferent projections: 1) A direct retinal projection and 2) an indirect projection from Layer V visual cortex. The retinal projection reaches the rat sSC by embryonic day 16, is topographic, and refines to form a high resolution map of visual space

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4

曾昭雪 and Chiu-suet Margaret Tsang. "The regulation of Endothelin-1 during mouse brain development and perinatal cerebral ischemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221749.

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5

Tsang, Chiu-suet Margaret. "The regulation of Endothelin-1 during mouse brain development and perinatal cerebral ischemia /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20622399.

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6

Fuchs, Claudia <1983&gt. "Effect of loss of CDKL5 on brain development in a new Cdkl5 knockout mouse model." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6190/.

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Rett's Syndrome (RTT) is a severe neurodevelopmental disorder, characterized by cognitive disability that appears in the first months/years of life. Recently, mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been detected in RTT patients characterized by early-onset seizures. CDKL5 is highly expressed in the brain starting from early postnatal stages to adulthood, suggesting the importance of this kinase for proper brain maturation and function. However, the role/s of CDKL5 in brain development and the molecular mechanisms whereby CDKL5 exerts its effects are still

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7

Kaeser, Franz Joseph. "The effect of temporary hypoxia on prostaglandin synthesis in mouse brain cell cultures during development /." [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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8

Mouzon, Benoit Christian. "Development and characterization of a novel mouse model of single and repetitive mild traumatic brain injury." Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590805.

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Mild traumatic brain injury (mTBI) or concussion is the most common form of TBI, and although a single concussion rarely results in long-term neurological dysfunction, repeated mild traumatic brain injury (r-mTBI) is a recognized risk factor for later development of neurodegenerative disease. However, the mechanisms contributing to neurodegeneration following TBI remain obscure. Animal models provide a means to examine the factors and mechanisms involved in TBI in experiments that cannot be conducted using human participants. The purpose of this thesis was to develop and fully characterize a r

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9

Edgar, Julia M. "An in vivo and in vitro investigation of development of the cerebral neocortex in the mouse brain." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22179.

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I used 5-bromo-2-deoxyuridine (BrdU) to label proliferating neuronal and glial precursors <I>in vivo</I> and used immunohistochemical techniques to investigate their distribution within the developing mouse neocortex at embryonic and early postnatal stages. I developed a double labelling protocol to study the antigenic characteristics to the glial cells. I showed how neuronal and glial precursors invade the developing neocortex, characterised the glial cells in terms of their antigenic properties and investigated their proliferative behaviour. To investigate the factors that regulate the forma

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10

Marfull, Oromí Pau. "Analysis of mouse embryonic brains deficient for Rnd3: implications in axonal, subpallial and cortical development." Doctoral thesis, Universitat de Lleida, 2019. http://hdl.handle.net/10803/668951.

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Rnd3 és una RhoGTPasa amb activitat constitutiva que promou el creixement de neurites in vitro i promou la migració radial en l'escorça. Malgrat la seva clara participació en el desenvolupament neuronal, l'efecte de la depleció de Rnd3 en cervell d'embrions encara no s'havia analitzat. En aquesta tesi, primer hem aportat un patró detallat d'expressió de Rnd3 i el fenotip de cervells embrionaris del knockout de Rnd3. Hem determinat que Rnd3 és essencial per a la correcta formació del globus pàl·lid, el corridor i, indirectament, les vies axonals talamocorticals (TCAs) i estriatals (SAs). Respec

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11

Allen, Zegary J. "Transcription Factor Regulation of Olfactory Bulb Interneuron Heterogeneity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1273166739.

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12

Hu, Ling. "A mouse line for inducible and reversible silencing of specific neurons (Part I) ; The roles of Ulk4 on cerebral cortex development (Part II)." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231373.

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Part I abstract: Genetic methods for inducibly and reversibly inhibiting neuronal activity of specific neurons are critical for exploring the functions of neuronal circuits. The engineered human glycine receptor, called ivermectin (IVM)-gated silencing receptor (IVMR), has been shown to possess this ability in vitro, which abolish the binding with endogenous glycine and improve the sensitivity to ivermectin. Based on that, we constructed the knock-in plasmid which put IVMR in the downstream of a loxP-flanked STOP cassette. The Rosa26-IVMR mouse line was generated by inserting the plasmid into

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13

Alvarez-Saavedra, Matias A. "The Snf2h and Snf2l Nucleosome Remodeling Proteins Co-modulate Gene Expression and Chromatin Organization to Control Brain Development, Neural Circuitry Assembly and Cognitive Functions." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30304.

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Chromatin remodeling enzymes are instrumental for neural development as evidenced by their identification as disease genes underlying human disorders characterized by intellectual-disability. In this regard, the murine Snf2h and Snf2l genes show differential expression patterns during embryonic development, with a unique pattern in the brain where Snf2h is predominant in neural progenitors, while Snf2l expression peaks at the onset of differentiation. These observations led me to investigate the role of Snf2h and Snf2l in brain development by using conditionally targeted Snf2h and Snf2l mice.

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14

Schmouth, Jean-François. "The use of novel humanized mouse models and transcriptome characterization to study the neurogenesis factor, NR2E1, in brain and eye development." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43530.

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15

Weiß, Stefan Johann Andreas Verfasser], Angelika [Gutachter] [Schnieke, and Wolfgang [Akademischer Betreuer] [Gutachter] Wurst. "The role of Glypican 4 during mouse brain development / Stefan Johann Andreas Weiß ; Gutachter: Wolfgang Wurst, Angelika Schnieke ; Betreuer: Wolfgang Wurst." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1137323485/34.

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16

Hammelrath, Luam Kidane [Verfasser]. "Imaging a life span : In vivo Magnetic Resonance Imaging of Development and Ageing in Rat and Mouse Brain / Luam Kidane Hammelrath." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1096330067/34.

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17

Jarrar, Wassan [Verfasser], and Hans-Henning [Akademischer Betreuer] Arnold. "Genetic analysis of Nkx2.2 and Nkx2.9 transcription factors in mouse brain development: specific functions in the hindbrain / Wassan Jarrar ; Betreuer: Hans-Henning Arnold." Braunschweig : Technische Universität Braunschweig, 2014. http://d-nb.info/1175821233/34.

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18

Freund, Julia. "Emergence of individual behavioural traits and associated hippocampal plasticity in genetically identical mice." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-165013.

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Die Erforschung der Zusammenhänge zwischen Gehirnplastizität und individuellem Verhalten gestaltet sich aufgrund ihrer Komplexität im Tiermodell schwierig. Die vorliegende Studie wurde im mit dem Ziel konzipiert, die Individualitätsentwicklung bei Mäusen mit den gleichen physiologischen und genetischen Voraussetzungen in einer komplexen räumlichen und sozialen Umgebung zu beschreiben. Ich untersuchte die Korrelation dieser Entwicklung mit der Neurogenese im adulten Hippokampus als Maß für Gehirnplastizität. Zu diesem Zweck wurden zwei je mit einem automatisierten RFID-Tracking-System ausgestat

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19

Biesemann, Christoph [Verfasser], Etienne [Akademischer Betreuer] Herzog, Nils [Akademischer Betreuer] Brose, Dieter [Akademischer Betreuer] Klopfenstein, and Reinhard [Akademischer Betreuer] Jahn. "Development of Fluorescence Activated Synaptosome Sorting (FASS) and analysis of VGLUT1 synapses from mouse brain / Christoph Biesemann. Gutachter: Nils Brose ; Dieter Klopfenstein ; Reinhard Jahn. Betreuer: Etienne Herzog." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1042305609/34.

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20

Klink, Axel [Verfasser], Bodo [Akademischer Betreuer] Laube, and Ralf [Akademischer Betreuer] Galuske. "Impact of Low-Dose Ionizing Radiation on Cognitive Abilities in the Mouse : Assessment of Radiation Sensitivity during Pre- and Postnatal Brain Development / Axel Klink ; Bodo Laube, Ralf Galuske." Darmstadt : Universitäts- und Landesbibliothek, 2021. http://d-nb.info/1230554572/34.

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21

Kolmogorova, Daria. "Sex Differences In the Enduring Neuroinflammatory and Behavioural Sequelae of Systemic Immune Challenge During Puberty." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42155.

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Puberty is a critical period for sexual maturation during which the sex-specific reorganization and remodelling of the pubertal brain facilitate sex biases in stress sensitivity. Pubertal (i.e., six-week-old) CD-1 mice treated with the bacterial endotoxin lipopolysaccharide (LPS; 1.5 mg/kg body weight, ip) show several sex-specific changes to the neuroendocrine and behavioural systems of several reproductive and non-reproductive functions. One promising explanation for the elusive mechanisms driving the sex-specific outcomes of pubertal immune challenge may lie in the cascade of neuroimmune ev

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22

Ward, Brittney M. "Analyzing consequences to astrocytes in a mouse model of brain arteriovenous malformation." Ohio University Honors Tutorial College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1619298440206905.

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23

Kandalai, Shruthi M. "Exploring causes of pericyte expansion in postnatal brain of Rbpj-mediated mouse model of arteriovenous malformation." Ohio University Honors Tutorial College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1619194591764377.

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24

Kultima, Kim. "Transcriptomics and Proteomics Applied to Developmental Toxicology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7921.

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25

Mokrani, Sofiane. "Maintenance de la stabilité chromosomique des cellules souches neurales murines au cours du développement et après un stress génotoxique aiguë ou chronique Impaired brain development and behavior of Xlf null mice linked to chromosome instability-induced premature neurogenesis Higher Chromosome Stability in Mouse Embryonic Neural Stem and Progenitor Cells than in Fibroblasts in Response to Acute or Chronic Genotoxic Stress." Thesis, Institut polytechnique de Paris, 2019. http://www.theses.fr/2019IPPAX010.

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Une exposition prénatale aux radiations ionisantes est associée au développement de pathologies neurodéveloppementales liées à l’induction de dommages à l’ADN dans les cellules souches et progéniteurs neuraux (CSPN). Ainsi, la stabilité génétique des CSPN est cruciale pour le développement et l’homéostasie du cerveau. Cependant, des altérations génomiques au niveau des CSPN au cours du développement pourraient promouvoir la diversité neuronale. XLF est un composant de la voie de réparation d’ADN par NHEJ (pour Non-Homologous End-Joining). Nous avons montré une augmentation de l’instabilité des

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26

Mariani, Jean. "Elimination de synapses fonctionnelles au cours du developpement du systeme nerveux central : etude electrophysiologique dans le systeme olivo-cerebelleux des rongeurs." Paris 6, 1987. http://www.theses.fr/1987PA066510.

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27

Chauhan, Disha. "Analysis of the Expression Pattern of Transmembrane proteins with extracellular leucine rich repeats (eLRRs) in the developing nervous system." Doctoral thesis, Universitat de Lleida, 2014. http://hdl.handle.net/10803/145645.

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Repeticions riques en leucina (RRL ) és uns seqüència conservada d'11 aminoàcids alifàtics incloent leucina implicada en la interacció proteïna-proteïna Proteïnes transmembrana (TM) amb RRLs extracel.lular (eRRLs) han sorgit recentment com a reguladors clau de diversos processos durant el desenvolupament dels circuits neuronals: en l'extensió axonal, en la funció sinàptica i en la migració neuronal. No obstant això, per a la majoria de les eRRL-TMs, el seu paper en el desenvolupament del sistema nerviós i la funció és desconeguda. Amb l'objectiu d'avaluar la seva funció, es va realitzar un es

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28

Hajeri-Germond, Michèle. "Etude comparative concernant l'incorporation de l'alpha-foetoproteine au cours de la differenciation ontogenique et cancerogenique du systeme nerveux central et peripherique." Paris 7, 1988. http://www.theses.fr/1988PA077185.

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29

Shojaeian-Zanjani, Mohammad-Hadi. "Etude en cytologie quantitative de l'olive bulbaire des rongeurs : relation entre mort neuronale et elimination synaptique au cours du developpement et role des cellules cibles dans la regulation du nombre des neurones olivaires." Paris 6, 1987. http://www.theses.fr/1987PA066211.

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30

Leonard, James W. Jr. "Replacing indirect manual assistive solutions with hands-free, direct selection." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1309282777.

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31

Drozd, Malgorzata. "Caractérisation fonctionnelle des nouveaux gènes et des voies moléculaires impliquées dans les troubles du développement du cerveau." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://theses.univ-cotedazur.fr/2020COAZ6021.

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Les troubles du développement du cerveau (DBD) englobent un groupe très hétérogène de troubles provenant du dysfonctionnement cérébral du développement. Les DBD comprennent, entre autres, la déficience intellectuelle, certaines formes d’épilepsie, le trouble du spectre autistique (TSA), le trouble d’hyperactivité avec déficit de l’attention, les troubles de l’apprentissage et du langage et la schizophrénie. Au cours de ma thèse, j’ai participé à deux projets de recherche distincts. Le premier projet visait la caractérisation fonctionnelle de nouveaux gènes impliqués dans la schizophrénie à déb

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32

Lu, Li-Chen, and 盧俐蓁. "Functional characterization of Zfp568 during mouse brain development." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/06787090052783674179.

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碩士<br>國立陽明大學<br>生命科學暨基因體科學研究所<br>98<br>M003-A06 is a novel gene which was identified from our macaque brain sequencing project. Its mouse homologue was Zfp568, a Krüppel-associated box (KRAB) domain zinc-finger protein. The development of the Zfp568 mutant mouse line, named Chato, arrests at midgestation and the convergent extension is defected. To validate the function of Zfp568 during mouse brain development, mouse neuroblastoma Neuro-2a cell line was utilized as a model for neuronal differentiation. As a result, Western blot and RT-PCR showed that the Zfp586 expression was decreased during

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33

LIU, HSIN-YU, and 劉欣瑜. "The Role of TLR7 in Neuronal Morphogenesis During Mouse Brain Development." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/49075034736570046830.

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博士<br>國防醫學院<br>生命科學研究所<br>102<br>Toll-like receptor (TLR) family has been known as a critical danger sensor in innate immune system through recognition of both pathogen- and damage-associated molecular patterns to against invading pathogens. In addition to immune cells, some of TLRs are expressed in neurons and involved in the regulation of neurogenesis, neurite growth and neurodegeneration. However, the downstream signal pathways and effectors for TLRs in neurons are still controversial. In this thesis, it is evidenced that TLR7 negatively regulates dendritic growth through the canonical myel

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34

Shaw, Patricia Rein. "Identifying phenotypic change across time in mouse models of Down syndrome." Thesis, 2021. https://hdl.handle.net/2144/42320.

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Advances in Down syndrome (DS) research depend on the availability of mouse models that replicate the genetic landscape and resulting phenotypes of DS which allow for experimental manipulation to correlate cellular and molecular changes with behavior, in a way that is not possible with human studies alone. These models have been a critical component in understanding the underlying mechanism of the intellectual disability in people with Down syndrome. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulates many of the phenotypes seen in individuals with Down

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35

"Specific Functions of ERK/MAPK Signaling in Brain Development and Neurocognition." Doctoral diss., 2019. http://hdl.handle.net/2286/R.I.55550.

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abstract: Development of the cerebral cortex requires the complex integration of extracellular stimuli to affect changes in gene expression. Trophic stimulation activates specialized intracellular signaling cascades to instruct processes necessary for the elaborate cellular diversity, architecture, and function of the cortex. The canonical RAS/RAF/MEK/ERK (ERK/MAPK) cascade is a ubiquitously expressed kinase pathway that regulates crucial aspects of neurodevelopment. Mutations in the ERK/MAPK pathway or its regulators give rise to neurodevelopmental syndromes termed the “RASopathies.” RASopath

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Zhou, ZhiCheng. "Patterns of expression of oligodendrocyte specific proteins during development of the mouse brain." 2009. http://hdl.handle.net/1993/21559.

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Pires, Joana Filipa Mariano. "Characterization of amisyn expression and localization in the brain over mouse lifespan." Master's thesis, 2020. http://hdl.handle.net/10773/29008.

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Functionally, the nervous system is responsible for regulating behaviour and maintaining the organism homeostasis. The learning and memory processes are complex and occur in several brain areas, but mainly in the hippocampus region. Selective genes modulate these processes by coding and producing several proteins that regulate the processes of exocytosis and synaptic transmission. Guided by clues, the vesicles approach the contact points of nerve cells (synapses) and use the SNARE proteins to fuse with the plasma membrane and release neurotransmitters that stabilize the synapse and init

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(8755629), Laura E. Hawley. "Quantifying DYRK1A during perinatal development in the hippocampus, cerebral cortex, and cerebellum of the Ts65Dn mouse model." Thesis, 2020.

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<p>The relationship between gene copy number and protein expression levels has not thoroughly been examined in humans or mouse models of Down syndrome (DS) in relationship to developmental changes in the trisomic brain. Found on human chromosome 21 (Hsa21) and triplicated in DS, Dual-specificity tyrosine-phosphorylated regulated kinase 1A (<i>DYRK1A)</i> has been linked in DS to neurological deficits by restricting cell growth and proliferation. Little information exists regarding DYRK1A during perinatal development and how its expression may lead to cognitive deficits, and none exists that

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WU, PEI-JUNG, and 吳佩蓉. "The Role of AIM2 Inflammasome in Neuronal Morphogenesis and Behaviors During Mouse Brain Development." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/5q3t4w.

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博士<br>國防醫學院<br>生命科學研究所<br>105<br>Inflammasomes are the protein assemblies that consist of inflammasome sensors, adaptor apoptosis associated speck-like proteins containing a CARD (ASC) and inflammasome caspase. Inflammasomes sense various danger signals to trigger proteolytic processing and secretion of IL-1 cytokines. Recent studies have suggested that neurons use their own innate immune system to detect danger signals and regulate neuronal morphology. Here, we investigate whether inflammasomes, the critical components of innate immunity, participate in regulation of neuronal morphology and

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Biesemann, Christoph. "Development of Fluorescence Activated Synaptosome Sorting (FASS) and analysis of VGLUT1 synapses from mouse brain." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-000D-F0C0-C.

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Chen, Chien-Chang, та 陳建彰. "HIF2α promotes Glioblastoma Multiforme tumor development in mouse brain via direct regulation of Bmi1 expression". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/26805243430526433071.

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博士<br>國立中興大學<br>生物化學研究所<br>102<br>Glioblastoma multiforme (GBM) is the most malignancy in brain tumors with the GBM characteristic of intratumoral hypoxia. The hypoxia condition can stabilize hypoxia inducible factors (HIFs) to activate hypoxic responsive genes expression to induce epithelial-mesenchymal transition (EMT) and maintain tumor cells stemness.Previous studies indicated that HIF1α was stable in GBM samples and regulate tumor metastasis. HIF2α and multiple hypoxia responsive genes were found to be expressed in glioma stem cells (GCGs). Role of HIF2α may be also important in GBM tumor

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Onvani, Sara. "Effects of Aberrant HGF/MET Signalling on Cerebellar Development and Medulloblastoma Pathogenesis." Thesis, 2012. http://hdl.handle.net/1807/33766.

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Medulloblastoma is the most common malignant paediatric brain tumour. Similar to other tumours, medulloblastoma pathogenesis involves abnormal regulation of several developmental growth pathways. As my thesis project, I studied the effects of aberrant HGF/MET signalling on medulloblastoma formation in two ways. In my first objective, I investigated the role that mutations play in activated HGF/MET signalling in medulloblastoma by searching for mutations in HGF/MET pathway genes, SPINT1, SPINT2, and MET, within primary medulloblastoma specimens. This screen identified several single nucleotide

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Petropoulos, Sophie. "Developmental Expression, Function, and Regulation of Multidrug Resistance in the Mouse Placenta and Fetal Brain." Thesis, 2011. http://hdl.handle.net/1807/32189.

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During pregnancy, 64-96% of women take at least one prescription drug. The placenta is the primary barrier between substrates in maternal and fetal circulation. The blood-brain barrier (BBB) acts as an additional barrier for the fetal brain, which is particularly susceptible to the effects of xenobiotics. Multidrug resistance phosphoglycoprotein (P-gp; encoded by Abcb1 mRNA) and breast cancer resistance protein (Bcrp1; encoded by Abcg2 mRNA) are efflux transporters localized on placental syncytiotrophoblast and capillary endothelial cells of the BBB. Placental Abcb1/P-gp and Abcg2/Bcrp1 li

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Thiessen, Jonathan. "Development and application of quantitative MRI methods for assessing white matter integrity in the mouse brain." 2012. http://hdl.handle.net/1993/9221.

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Healthy white matter in the brain and spinal cord is composed primarily of myelinated axons and glial cells. Myelinated axons transfer information between the peripheral nervous system and the central nervous system (CNS) as well as between centres within the CNS. Demyelination, a hallmark of neurodegenerative autoimmune diseases such as multiple sclerosis (MS), can cause nerve damage and degrade signal propagation. Magnetic resonance imaging (MRI) methods thought to assess myelin integrity and the structural integrity of axons are improving both the diagnosis and understanding of white matter

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Joshi, Parth Devesh. "Molecular characterization and functional analysis of a novel long noncoding RNA in the mouse." Doctoral thesis, 2019. http://hdl.handle.net/11858/00-1735-0000-002E-E64A-D.

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Bhuiyan, Manzerul. "Modulation of Multidrug Resistance Phosphoglycoprotein in the Mouse Placenta and Fetal Brain by the Selective Serotonin Reuptake Inhibitor Sertraline and Maternal Bacterial Infection." Thesis, 2012. http://hdl.handle.net/1807/42894.

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Multidrug resistance phosphoglycoprotein (P-gp) is expressed in the placenta and fetal blood-brain barrier (BBB) and plays a critical role in reducing fetal accumulation of xenobiotics. In other tissues, P-gp activity is inhibited by selective serotonin reuptake inhibitors (SSRIs) and by lethal doses of LPS modeling a bacterial infection. However, nothing is known with respect to the effects of SSRIs or nonlethal infection on P-gp activity in the placenta or fetal tissues. In the studies presented in this thesis, we hypothesized that (1) the SSRI sertraline and (2) a nonlethal maternal bacteri

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Anderson, Miranda. "Analysis of the role of Reelin in mouse brain development: Reelin positive non-gabaergic populations and impact of haploinsufficience on neuronal morpology." Thesis, 2015. https://hdl.handle.net/2144/16032.

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Reelin, a large extracellular matrix protein responsible for migration and laminar positioning of neurons during brain development, has been implicated in the pathogenesis of schizophrenia and autism. There are extensive populations that have been identified in the adult mouse brain which contain cells secreting Reelin; previously these neurons were believed to be almost exclusively GABAergic. We used immunohistochemistry to reveal multiple groups of Reelin positive neurons that are not GABAergic. Specifically, we used Reelin and GABA antibodies or Vgat cre::Ai9 tdTomato to analyze whether R

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Klink, Axel. "Impact of Low-Dose Ionizing Radiation on Cognitive Abilities in the Mouse : Assessment of Radiation Sensitivity during Pre- and Postnatal Brain Development." Phd thesis, 2021. https://tuprints.ulb.tu-darmstadt.de/17535/13/20210127_Dissertation_Axel_Klink_Ver%C3%B6ffentlichung.pdf.

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In our modern society various sources of radiation are omnipresent. Sectors like nuclear power generation, long distance air travel and medical radiation diagnostics rank among the most prominent. Especially, the amount of medically necessary radiation is increasing and represents a major source of exposure in the general population. Therefore, radiation protection and the epidemiology of radiation have gained in importance. The risk possibly arising from exposure to low-dose radiation is still part of intensive and ongoing debates, demonstrating that current results are still controversial. C

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Majaess, Namat-Maria. "A Loss of the Fragile X mental retardation protein alters the spatial and temporal expression of glutamate receptors in the mouse brain." Thesis, 2012. http://hdl.handle.net/1828/4372.

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Fragile X Syndrome (FXS) is the leading cause of inherited intellectual disability. The disorder is caused by a trinucleotide expansion that silences the Fragile X Mental Retardation 1 (Fmr1) gene resulting in the loss of its protein product, the Fragile X Mental Retardation Protein (FMRP). FXS patients show broad clinical phenotypes including intellectual disability, as well as a number of cognitive and behavioral problems. The lack of FMRP is believed to be the direct cause of the deficits seen in FXS patients. FMRP is an RNA-binding protein that is expressed in the brain and testes. This p

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Miquelajauregui, Amaya. "Role of Smad-interacting Protein 1 (Sip1/Zfhx1b) in the development of the cerebral cortex." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B5EC-C.

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