Academic literature on the topic 'Mouse Brain Organoids'

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Journal articles on the topic "Mouse Brain Organoids"

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Roosen, Mieke, Chris Meulenbroeks, Phylicia Stathi, et al. "BIOL-11. PRECLINICAL MODELLING OF PEDIATRIC BRAIN TUMORS USING ORGANOID TECHNOLOGY." Neuro-Oncology 25, Supplement_1 (2023): i8. http://dx.doi.org/10.1093/neuonc/noad073.030.

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Abstract Molecular characterization has resulted in improved classification of pediatric brain tumors, leading to many novel (sub)types with distinct oncodriving events. To study tumor biology and to perform translational research on each of these tumors, preclinical models are essential. However, we are currently lacking sufficient models, especially in vitro, to represent each (sub)type and their heterogeneity. To generate large series of preclinical in vitro models for pediatric brain tumors, we are using organoid technology. Cells from patient samples and patient-derived xenograft samples
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Simsa, Robin, Theresa Rothenbücher, Hakan Gürbüz, et al. "Brain organoid formation on decellularized porcine brain ECM hydrogels." PLOS ONE 16, no. 1 (2021): e0245685. http://dx.doi.org/10.1371/journal.pone.0245685.

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Human brain tissue models such as cerebral organoids are essential tools for developmental and biomedical research. Current methods to generate cerebral organoids often utilize Matrigel as an external scaffold to provide structure and biologically relevant signals. Matrigel however is a nonspecific hydrogel of mouse tumor origin and does not represent the complexity of the brain protein environment. In this study, we investigated the application of a decellularized adult porcine brain extracellular matrix (B-ECM) which could be processed into a hydrogel (B-ECM hydrogel) to be used as a scaffol
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Zhai, Xin (Alice), Milagros Suarez Palacios, Zilu Huang, et al. "Abstract 3845: A matching panel of tumor organoids and patient derived orthotopic xenograft mouse models (PDOX) of high-grade gliomas in EGFP-based SCID mice." Cancer Research 85, no. 8_Supplement_1 (2025): 3845. https://doi.org/10.1158/1538-7445.am2025-3845.

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Background: High grade glioma, also known as glioblastoma multiform (GBM) a highly aggressive brain tumor, requires advanced systems to study tumor-stroma interactions. Paired in vitro and in vivo model systems such as 3D organoids and PDOX models derived from EGFP-SCID mice offered a unique opportunity to precisely and rapidly differentiation of mouse (EGFP positive) from human tumor cells, thereby facilitating the visualization and analysis of tumor/normal cell interactions in vitro and in vivo. Methods: EGFP-SCID mice received intra-cranial implantation of pediatric (n=6) and adult (n=6) GB
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Sukhinich, K. K., K. M. Shakirova, E. B. Dashinimaev, and M. A. Aleksandrova. "Development of 3D Cerebral Aggregates in the Brain Ventricles of Adult Mice." Russian Journal of Developmental Biology 52, no. 3 (2021): 164–75. http://dx.doi.org/10.1134/s1062360421030061.

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Abstract The cerebral organoids are three-dimensional cell cultures formed from brain-specific cell types arising from embryonic or pluripotent stem cells. Organoids provide an opportunity to study the early stages of brain development and diseases of the central nervous system. However, the modeling of organoids is associated with a number of unsolved problems. Organoid production techniques involve a complex cell culture process that requires special media, growth factors, and often the use of a bioreactor. Even under standardized conditions, structures of different morphology are formed: fr
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Bao, Zhongyuan, Kaiheng Fang, Zong Miao, et al. "Human Cerebral Organoid Implantation Alleviated the Neurological Deficits of Traumatic Brain Injury in Mice." Oxidative Medicine and Cellular Longevity 2021 (November 22, 2021): 1–16. http://dx.doi.org/10.1155/2021/6338722.

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Traumatic brain injury (TBI) causes a high rate of mortality and disability, and its treatment is still limited. Loss of neurons in damaged area is hardly rescued by relative molecular therapies. Based on its disease characteristics, we transplanted human embryonic stem cell- (hESC-) derived cerebral organoids in the brain lesions of controlled cortical impact- (CCI-) modeled severe combined immunodeficient (SCID) mice. Grafted organoids survived and differentiated in CCI-induced lesion pools in mouse cortical tissue. Implanted cerebral organoids differentiated into various types of neuronal c
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Ferdaos, Nurfarhana, Sally Lowell, and John O. Mason. "Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains." PLOS ONE 17, no. 11 (2022): e0278147. http://dx.doi.org/10.1371/journal.pone.0278147.

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Cerebral organoids show great promise as tools to unravel the complex mechanisms by which the mammalian brain develops during embryogenesis. We generated mouse cerebral organoids harbouring constitutive or conditional mutations in Pax6, which encodes a transcription factor with multiple important roles in brain development. By comparing the phenotypes of mutant organoids with the well-described phenotypes of Pax6 mutant mouse embryos, we evaluated the extent to which cerebral organoids reproduce phenotypes previously described in vivo. Organoids lacking Pax6 showed multiple phenotypes associat
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García-Delgado, Ana Belén, Rafael Campos-Cuerva, Cristina Rosell-Valle, et al. "Brain Organoids to Evaluate Cellular Therapies." Animals 12, no. 22 (2022): 3150. http://dx.doi.org/10.3390/ani12223150.

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Animal models currently used to test the efficacy and safety of cell therapies, mainly murine models, have limitations as molecular, cellular, and physiological mechanisms are often inherently different between species, especially in the brain. Therefore, for clinical translation of cell-based medicinal products, the development of alternative models based on human neural cells may be crucial. We have developed an in vitro model of transplantation into human brain organoids to study the potential of neural stem cells as cell therapeutics and compared these data with standard xenograft studies
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Yakoub, Abraam M., and Mark Sadek. "Analysis of Synapses in Cerebral Organoids." Cell Transplantation 28, no. 9-10 (2019): 1173–82. http://dx.doi.org/10.1177/0963689718822811.

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Cerebral organoids are an emerging cutting-edge technology to model human brain development and neurodevelopmental disorders, for which mouse models exhibit significant limitations. In the human brain, synaptic connections define neural circuits, and synaptic deficits account for various neurodevelopmental disorders. Thus, harnessing the full power of cerebral organoids for human brain modeling requires the ability to visualize and analyze synapses in cerebral organoids. Previously, we devised an optimized method to generate human cerebral organoids, and showed that optimal organoids express m
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Estridge, R. Chris, Jennifer E. O’Neill, and Albert J. Keung. "Matrigel Tunes H9 Stem Cell-Derived Human Cerebral Organoid Development." Organoids 2, no. 4 (2023): 165–76. http://dx.doi.org/10.3390/organoids2040013.

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Human cerebral organoids are readily generated from human embryonic stem cells and human induced pluripotent stem cells and are useful in studying human neurodevelopment. Recent work with human cerebral organoids have explored the creation of different brain regions and the impacts of soluble and mechanical cues. Matrigel is a gelatinous, heterogenous mixture of extracellular matrix proteins, morphogens, and growth factors secreted by Engelbreth-Holm-Swarm mouse sarcoma cells. It is a core component of almost all cerebral organoid protocols, generally supporting neuroepithelial budding and tis
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Antonica, Francesco, Lucia Santomaso, Davide Pernici, et al. "MODL-22. Establishment of a novel system to specifically trace and ablate quiescent/slow cycling cells in high-grade glioma." Neuro-Oncology 24, Supplement_1 (2022): i173. http://dx.doi.org/10.1093/neuonc/noac079.645.

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Abstract Pediatric and adult high-grade gliomas are the most common malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after surgical removal and chemotherapy. Quiescent/slow cycling stem cells have been proposed to be one of the main players of tumor relapse but their involvement in in the infiltration remain unclear. Despite they have been described in mouse models or after transcriptional profiling of human tumor samples, their direct visualization, targeting and ablation remains a challenge. Here, we identified a population of malignant cells expressing Pr
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Dissertations / Theses on the topic "Mouse Brain Organoids"

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Koshy, Aysis. "Characterization of Neural Development : Linking Retinoic Acid Receptors to Cell Fate and Modelling Tumorigenesis in Brain Organoids." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL119.

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Le développement du système nerveux central dans l'embryon dépend d'une signalisation opportune et précise des molécules. L'acide rétinoïque est l'une de ces molécules bien caractérisées par son impact sur le développement du cerveau et des yeux. Sous sa forme métaboliquement active, l'ATRA (acide All Trans Retinoïque) se lie aux récepteurs de l'acide rétinoïque (RAR) et contrôle l'expression d'une panoplie de gènes participant à des évènements impliqués dans la maturation cellulaire ainsi qu'à l'apoptose. Le RAR existe sous trois isotypes - RARα, RARβ et RARγ. Au cours du développement embryo
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Conference papers on the topic "Mouse Brain Organoids"

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Chen, Xi, Mikhail Kandel, Shitong Zhao, et al. "Computationally enhanced quantitative phase imaging for label-free organoids and in vivo mouse brains." In Quantitative Phase Imaging XI, edited by YongKeun Park and Yang Liu. SPIE, 2025. https://doi.org/10.1117/12.3040959.

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