Academic literature on the topic 'Mouse Derived Transcription Factors'

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Journal articles on the topic "Mouse Derived Transcription Factors"

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Maeda, K., M. Nakashima, S. Komori, and T. Watanabe. "Trans-acting regulatory factors for T cell antigen receptor alpha- and gamma-chain gene expression." Journal of Immunology 140, no. 8 (1988): 2796–801. http://dx.doi.org/10.4049/jimmunol.140.8.2796.

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Abstract BALB/c mouse thymoma-derived T cell line, CAK4.4 (Thy-1+, L3T4-, Lyt-2-), produced a large amount of TCR-gamma mRNA, a trace amount of TCR-beta mRNA but no detectable level of TCR-alpha mRNA. Another BALB/c mouse thymoma-derived T cell line, CAK1.3 (Thy-1+, L3T4+, Lyt-2+), synthesized a high level of TCR-alpha as well as TCR-beta mRNA but did not produce any amount of TCR-gamma mRNA. HAT-sensitive clones were established from the two T cell lines. Azaguanine-resistant, HPRT- CAK4.4 cells and bromodeoxyuridine-resistant, TK- CAK1.3 cells were fused by electrofusion method and the resul
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Costa, Robert H., Vladimir V. Kalinichenko, and Lorena Lim. "Transcription factors in mouse lung development and function." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 5 (2001): L823—L838. http://dx.doi.org/10.1152/ajplung.2001.280.5.l823.

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Development of the mouse lung initiates on day 9.5postcoitum from the laryngotracheal groove and involves mesenchymal-epithelial interactions, in particular, those between the splanchnic mesoderm and epithelial cells (derived from foregut endoderm) that induce cellular proliferation, migration, and differentiation, resulting in branching morphogenesis. This developmental process mediates formation of the pulmonary bronchiole tree and integrates a terminal alveolar region with an extensive endothelial capillary bed, which facilitates efficient gas exchange with the circulatory system. The major
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Gray, Paul A. "Transcription factors and the genetic organization of brain stem respiratory neurons." Journal of Applied Physiology 104, no. 5 (2008): 1513–21. http://dx.doi.org/10.1152/japplphysiol.01383.2007.

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Breathing is a genetically determined behavior generated by neurons in the brain stem. Transcription factors, in part, determine the basic developmental identity of neurons, but the relationships between these genes and the neural populations generating and modulating respiration are unclear. The diversity of brain stem populations has been proposed to result from a combinatorial code of transcription factor expression corresponding to the anterior-posterior (A-P) and dorsal-ventral (D-V) location of a neuron's birth. I provide a schematic of transcription factor coding identifying at least 15
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Kaarbø, Mari, Denis I. Crane, and Wayne G. Murrell. "RhoA Regulation of Cardiomyocyte Differentiation." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/491546.

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Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promoter region of mouse RhoA identified putative consensus sequence binding sites for several transcription factors involved in heart formation and organogenesis generally. Using luciferase reporter assays,
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Boucher, DM, and RA Pedersen. "Induction and differentiation of extra-embryonic mesoderm in the mouse." Reproduction, Fertility and Development 8, no. 4 (1996): 765. http://dx.doi.org/10.1071/rd9960765.

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Extra-embryonic mesoderm, derived at the time of gastrulation from the primitive streak, gives rise to several tissues that function to provide the embryo with nutrients, a means of waste disposal, and mechanical protection. Little is known about the differentiation of this tissue and about the growth and transcription factors involved. The present review focussed on growth and transcription factors that may be involved in differentiation of extra-embryonic mesoderm, and results from fate-mapping and transplantation studies. Methods in vitro available for assaying the effects of growth and tra
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Maeda, Yutaka, Vrushank Davé, and Jeffrey A. Whitsett. "Transcriptional Control of Lung Morphogenesis." Physiological Reviews 87, no. 1 (2007): 219–44. http://dx.doi.org/10.1152/physrev.00028.2006.

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The vertebrate lung consists of multiple cell types that are derived primarily from endodermal and mesodermal compartments of the early embryo. The process of pulmonary organogenesis requires the generation of precise signaling centers that are linked to transcriptional programs that, in turn, regulate cell numbers, differentiation, and behavior, as branching morphogenesis and alveolarization proceed. This review summarizes knowledge regarding the expression and proposed roles of transcription factors influencing lung formation and function with particular focus on knowledge derived from the s
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Song, Shuang, Chun Cao, Mohamed-Amin Choukrallah, et al. "OBF1 and Oct factors control the germinal center transcriptional program." Blood 137, no. 21 (2021): 2920–34. http://dx.doi.org/10.1182/blood.2020010175.

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Abstract OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell–specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here, we show by chromatin immunoprecipitation-sequencing that OBF1 extensively colocalizes with OCT1 and OCT2. We found that these factors also often colocalize with transcription factors of the ETS family. Furthermore, we showed that OBF1, OCT2, and OCT1 bind widely to the promoters or enhancers of genes involved in GC formation in mouse and human GC B cells. Short hairp
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Woodward, J. G., K. W. Omer, and P. M. Stuart. "MHC class II transcription in different mouse cell types. Differential requirement for protein synthesis between B cells and macrophages." Journal of Immunology 142, no. 11 (1989): 4062–69. http://dx.doi.org/10.4049/jimmunol.142.11.4062.

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Abstract Although the MHC class II genes are known to be regulated transcriptionally, the relative rates of transcription of the four classical class II genes in different cell types have not been investigated. Using nuclear transcriptional analysis, we have investigated the transcriptional rates of the class II genes in the macrophage cell line WEHI-3, normal bone marrow-derived macrophages, L-929 cells, and two different B cell lymphoma lines. Kinetic analysis of class II transcription in IFN-gamma-treated WEHI-3 cells revealed a 4-h delay, followed by a rapid increase in transcription over
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Almendral, J. M., D. Sommer, H. Macdonald-Bravo, J. Burckhardt, J. Perera, and R. Bravo. "Complexity of the early genetic response to growth factors in mouse fibroblasts." Molecular and Cellular Biology 8, no. 5 (1988): 2140–48. http://dx.doi.org/10.1128/mcb.8.5.2140-2148.1988.

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Genes whose expression is growth factor regulated are likely to be important components in the mechanisms controlling cell proliferation and differentiation. With the aim of identifying some of those genes, a lambda cDNA library was prepared with poly(A)+ RNA from quiescent NIH 3T3 cells stimulated with serum for 4 h in the presence of cycloheximide. Differential screening of approximately 200,000 recombinant phage plaques revealed 2,540 clones that cross hybridized preferentially with [32P]cDNA derived from RNA of stimulated cells rather than with cDNA derived from nonstimulated cells. Cross
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Almendral, J. M., D. Sommer, H. Macdonald-Bravo, J. Burckhardt, J. Perera, and R. Bravo. "Complexity of the early genetic response to growth factors in mouse fibroblasts." Molecular and Cellular Biology 8, no. 5 (1988): 2140–48. http://dx.doi.org/10.1128/mcb.8.5.2140.

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Genes whose expression is growth factor regulated are likely to be important components in the mechanisms controlling cell proliferation and differentiation. With the aim of identifying some of those genes, a lambda cDNA library was prepared with poly(A)+ RNA from quiescent NIH 3T3 cells stimulated with serum for 4 h in the presence of cycloheximide. Differential screening of approximately 200,000 recombinant phage plaques revealed 2,540 clones that cross hybridized preferentially with [32P]cDNA derived from RNA of stimulated cells rather than with cDNA derived from nonstimulated cells. Cross
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Dissertations / Theses on the topic "Mouse Derived Transcription Factors"

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Britz, Olivier. "Role of proneural bHLH transcription factors in mouse telencephalic development." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13170.

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Le cerveau des mammifères est constitué de complexes réseaux de neurones associés à deux types de cellules gliales, les astrocytes et les oligodendrocytes. C'est une structure finement organisée dont la formation repose sur la production et le positionnement correct du nombre approprié des divers types cellulaires au cours du développement. Les progéniteurs indifférenciés s'engagent d'abord dans un lignage cellulaire puis se différencient en un sous-type spécifique de cellule. Cette maturation est liée à des changements précis dans l'expression génique, et récemment les facteurs de transcripti
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Yuan, Yuan, and 袁媛. "Transcriptional regulation of mouse secretin receptor in hypothalamic cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47752932.

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 As a neuropeptide, both secretin and secretin receptor are expressed in the central nervous system (CNS). It has been revealed that the activities of secretin on hypothalamic cells of rodents are important for osmoregulation and food intake. In the present study, embryonic mouse hypothalamic cell line N42 was used to study the promoter activity of mouse secretin receptor (mSR). By 5′ deletion analysis, a promoter element was identified within ?282 to ?443, relative to the ATG codon, and it contains a GC-box (-297 to -286), a ras responsive element (RRE) (-289 to -276) and an E-box (-416 to
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Nakaki, Fumio. "Induction of mouse germ-cell fate by transcription factors in vitro." Kyoto University, 2014. http://hdl.handle.net/2433/188684.

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Kotova, Irina. "Purification of general RNA polymerase II transcription factors from mouse for studies of proliferation-specific transcription." Doctoral thesis, Umeå : Department of Medical BIochemistry and Biophysics, Umeå University, 2003. http://publications.uu.se/umu/theses/abstract.xsql?dbid=91.

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Stoddart, Neil Richard. "A possible role for embryo-derived factors during mouse preimplantation development?" Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295921.

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Erickson, Drew Talyn. "Multiple Roles for the Transcription Factors Sox6 and Jumonji in Mouse Hematopoiesis." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195728.

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Sox6, a member of the Sox transcription factor family, is essential for the silencing of epsilon-y-globin gene expression in definitive erythropoiesis of mice and humans. Homozygous Sox6 null mice are neonatal lethal, precluding analysis at later stages. We created adult mice that are deficient in Sox6 specifically in hematopoietic tissues, by transplanting embryonic liver stem cells from Sox6-deficient mice into lethally-irradiated congenic wild-type adult mice. The mice receiving mutant stem cells (mutant-engrafted) showed high expression levels of epsilon-y in bone marrow, spleen and circu
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Hlatshwayo, Nkosikhona Rejoyce. "Comparison of protein binding microarray derived and ChIP-seq derived transcription factor binding DNA motifs." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1017907.

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Transcription factors (TFs) are biologically important proteins that interact with transcription machinery and bind DNA regulatory sequences to regulate gene expression by modulating the synthesis of the messenger RNA. The regulatory sequences comprise of short conserved regions of a specific length called motifs . TFs have very diverse roles in different cells and play a very significant role in development. TFs have been associated with carcinogenesis in various tissue types, as well as developmental and hormone response disorders. They may be responsible for the regulation of oncogenes and
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Chao, Christina Seng. "The roles of Nkx2.2 in determination of mouse islet cell fates /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Cell & Developmental Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 144-158). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Geng, Yuhong, and 耿雨紅. "Functional studies of SOX9 in mouse development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243071.

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Ho, Siu-yin Bryan, and 何兆賢. "Genetic analyses of the roles of Sox2 and Sox18 in mouse hair development and growth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206748.

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The mouse pelage hair consists of three types of hair coined primary (guard), secondary (awls and auchenes) and tertiary (zigzag) hair. They display distinct morphologies and are induced consecutively during hair morphogenesis. Previously two identified regulatory mouse mutants, Yellow submarine (Ysb) and Light coat and circling (Lcc) which the chromosomal rearrangements have disrupted the cis-acting regulatory elements of Sox2; resulting in the loss of Sox2 expression in the inner ear. The mutants displayed lighter hair coat color due to a reduction in the proportion of secondary hair and inc
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Books on the topic "Mouse Derived Transcription Factors"

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Partanen, Maija Elina. Expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse development and their functional interactions with Gli transcription factors. 2001.

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Hamner, Steve. Characterization of growth of mouse mammary cell lines in collagen gel matrix and modulation of growth by cell-derived diffusible factors. 1985.

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Razzoli, Maria, Alessandro Bartolomucci, and Valeria Carola. Gene-by-Environment Mouse Models for Mood Disorders. Edited by Turhan Canli. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.013.

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Much of the impact of genes on mood disorders likely depends on interactions between genes and the environment. Recent studies demonstrating an interaction between specific genes and life stressful events (early and/or adult) in the modulation of several mood disorders (e.g., serotonin transporter and brain-derived neurotrophic factor genes) have compelled researchers to incorporate information about adverse environmental experiences into the study of genetic risk factors; these same gene-by-environment (G×E) interactions have been identified in mouse models. Notably, G×E not yet described in
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Book chapters on the topic "Mouse Derived Transcription Factors"

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Cardozo, Christopher P. "Identification of Transcription Factor-Binding Sites in the Mouse FOXO1 Promoter." In FOXO Transcription Factors. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8900-3_3.

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Deatly, Anne M., Ashley T. Haase, and Melvyn J. Ball. "Herpes Simplex Virus Type 1 Transcription during Latent Infections of Mouse and Man." In Psychiatry and Biological Factors. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-5811-4_25.

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Scarno, Gianluca, Giuseppe Pietropaolo, Chiara Di Censo, Giovanna Peruzzi, and Giuseppe Sciumè. "Assessing Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0338-3_6.

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Schaapveld, Roel, Jan Schepens, Frank Oerlemans, Michel Streuli, Bé Wieringa, and Wiljan Hendriks. "Gene Targeting of the Receptor-Like Protein Tyrosine Phosphatase Lar by Homologous Recombination in Mouse Embryonic Stem Cells." In Signalling Mechanisms — from Transcription Factors to Oxidative Stress. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79675-3_29.

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Schnapp, Andreas, Horst Rosenbauer, and Ingrid Grummt. "Trans-acting factors involved in species- specificity and control of mouse ribosomal gene transcription." In Molecular Mechanisms of Cellular Growth. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3886-8_17.

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Boado, Ruben J. "Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors." In Advances in Dementia Research. Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6781-6_27.

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Kaitsuka, Taku, and Kazuhito Tomizawa. "Generation of Functional Insulin-Producing Cells from Mouse Embryonic Stem Cells Through Protein of Transcription Factors." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0943-9_7.

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Ito, Yoshihisa, Kumiko Ishige, Masahiro Aizawa, and Hideomi Fukuda. "GABAB Antagonists Block γ-Butyrolactone-Induced Absence Seizures and Coordinated Induction of Transcription Factors in Mouse Brain." In GABA: Receptors, Transporters and Metabolism. Birkhäuser Basel, 1996. http://dx.doi.org/10.1007/978-3-0348-8990-2_35.

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Gagliardi, Francesco, and Claudia Angelini. "Discovering Typical Transcription-Factors Patterns in Gene Expression Levels of Mouse Embryonic Stem Cells by Instance-Based Classifiers." In New Trends in Image Analysis and Processing – ICIAP 2013. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-41190-8_41.

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Qiu, Boning, Ruben J. de Vries, and Massimiliano Caiazzo. "Direct Cell Reprogramming of Mouse Fibroblasts into Functional Astrocytes Using Lentiviral Overexpression of the Transcription Factors NFIA, NFIB, and SOX9." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1601-7_3.

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Conference papers on the topic "Mouse Derived Transcription Factors"

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Liu Yang, Jin Bo, Guo Bin, et al. "Expressions of transcription factors Ets1 and Ets2 in mouse testis tissue." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5965935.

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Miyake*, Shinji, Hiroyuki Kuraoka**, and Chikamune Wada**. "Heart Rate Variability as a Mental Workload Index." In Applied Human Factors and Ergonomics Conference. AHFE International, 2021. http://dx.doi.org/10.54941/ahfe100642.

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In this study, we investigated relationship between task characteristics such as sensory intake and cardiovascular responses. Nineteen male participants were asked to perform a mental arithmetic task (MA) and a computerized mirror tracing (MT) task for five minutes each. In the MA task, participants were instructed to respond within five seconds by pressing the left or right mouse button. Therefore, this task includes a high time pressure (temporal restriction). In the MT task, participants were required to trace a zigzag pathway displayed on a PC screen by using a mouse. The horizontal and ve
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Jamal, Mohammad S., Bilal B. Hafeez, and Ajit K. Verma. "Abstract 4204: Chronic ultraviolet radiation exposure of mouse skin activates GATA and PAX families of transcription factors, which regulate expression of cell survival genes." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4204.

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Xie, Jianping, Paul Rivas, Anuradha Soundararajan, et al. "Abstract 851: Interactions among transcription factors as a potential mechanism for inhibiting castrate-resistant prostate cancer (CRPCa) in transgenic adenocarcinoma of mouse prostate (TRAMP) through regulation of FLIP." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-851.

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Balaji, Swathi, Sachin S. Vaikunth, Jignesh K. Parvadia, Timothy M. Crombleholme, and Daria A. Narmoneva. "In Situ Tissue Engineering Using Angiogenic Nanoscaffold Enhances Diabetic Wound Healing in db/db Mouse Model." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192198.

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Tissue engineering offers an attractive alternative for treatment of chronic nonhealing diabetic ulcers, which account for more than 27% of the $10.9 billion total diabetic health care costs in the US annually [1]. The harsh environment of a diabetic ulcer is characterized by reduced expression of angiogenic factors, insufficient vascularization, excess protease activity, matrix degradation and hyperglycemia-induced cell apoptosis [2]. A major factor contributing to insufficient neovascularization in diabetic nonhealing wounds may be deficiency in the recruitment of endothelial cells (ECs) and
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Park, Heesook, Do Young Lim, Minhee Kim, and Jung Han Yoon Park. "Abstract 1823: Chronic consumption of a high-fat diet stimulates tumor growth and metastasis via the activation of key transcription factors in a CT26 mouse colon cancer allograft model." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1823.

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He, Weihong, Hengshu Chen, Kexin Chen, Tiantian Li, Simiao Wu, and Si Wang. "Pharmacological Inhibition of RUNX1 Suppresses Cardiac Cathepsin Expression and Preserves Cardiac Function Following Myocardial Infarction in Rats." In International Medicine and Health Sciences Congress. ECER, 2024. https://doi.org/10.53375/imhsc.2024.52.

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Cardiac cell death following myocardial infarction (MI) leads to irreversible loss of myocardium which in turn leads to adverse structural and functional changes of the heart, referred to as cardiac remodelling. Progression of adverse remodelling causes heart failure which is linked to increased deaths or hospitalizations. Runt-related transcription factor-1 (RUNX1) is a member of the core-binding factor family of transcription factors which regulate gene expression. Recent evidence showed that RUNX1 expression is increased following MI and negatively correlates with cardiac function. Dr He’s
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Shikata, Tetsuo, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita, and Ryohei Takeuchi. "Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Osteoblast-Like Cells." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-41797.

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Bone formation is subject in vivo to mechanical stimulation. Although many researches for bone cells of osteoblastic lineage sensing and responding to mechanical stimulation have been reported mainly in the biochemical field, effects of mechanical stimulation on bone cells are not well understood. In this study, in order to clarify effects of acceleration amplitude and frequency of mechanical stimulation on MC3T3-E1, which is an osteoblast-like cell line derived from mouse calvaria, in the sense of mechanical vibrations, their cell proliferation, cell morphology, bone matrix generation and gen
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Bernhagen, Max, and Angelika C Bullinger. "Towards Reliable Tactile Mid-Air Interfaces: Analysis of Influencing Factors of the Perception of Tactile Mid-Air Feedback." In 8th International Conference on Human Interaction and Emerging Technologies. AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002760.

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Human-machine interfaces require an efficient and reliable interaction under various con-ditions. Especially under conditions with high cognitive workload which require rapid situa-tion assessment, interfaces should reliably support the human perception. Here, research addresses gesture-based interfaces as a possible interface to enable intuitive interactions based on ingrained daily routines. Using spatial commands executed by the bare hand, one can recreate real world interactions like pushing a knob, turning a controller, or using a ges-ture as an input command. In comparison to real input
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Reports on the topic "Mouse Derived Transcription Factors"

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Splitter, Gary A., Menachem Banai, and Jerome S. Harms. Brucella second messenger coordinates stages of infection. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7699864.bard.

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Aim 1: To determine levels of this second messenger in: a) B. melitensiscyclic-dimericguanosinemonophosphate-regulating mutants (BMEI1448, BMEI1453, and BMEI1520), and b) B. melitensis16M (wild type) and mutant infections of macrophages and immune competent mice. (US lab primary) Aim 2: To determine proteomic differences between Brucelladeletion mutants BMEI1453 (high cyclic-dimericguanosinemonophosphate, chronic persistent state) and BMEI1520 (low cyclicdimericguanosinemonophosphate, acute virulent state) compared to wild type B. melitensisto identify the role of this second messenger in esta
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Yu, Mei, Pengyu Wang, Binbin Li, et al. NRSF Negatively Regulates Microglial Pro-Inflammatory Activation. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.20.02.

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Microglial activation contributes to neurological disorders like Parkinson’s disease (PD), and modulating this activation is a potential therapeutic approach. The neuron-restrictive silencer factor (NRSF) functions as a negative regulator of gene transcription through epigenetic modifications. While previous research has primarily examined the role of NRSF in neuronal differentiation and injury, emerging evidence indicates that NRSF also plays a significant role in maintaining the phenotype of glial cells. In this study, we explored the role and underlying mechanisms of NRSF in lipopolysacchar
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Elroy-Stein, Orna, and Dmitry Belostotsky. Mechanism of Internal Initiation of Translation in Plants. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696518.bard.

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Original objectives Elucidation of PABP's role in crTMV148 IRES function in-vitro using wheat germ extract and krebs-2 cells extract. Fully achieved. Elucidation of PABP's role in crTMV148 IRES function in-vivo in Arabidopsis. Characterization of the physical interactions of PABP and other potential ITAFs with crTMV148 IRES. Partly achieved. To conduct search for additional ITAFs using different approaches and evaluate the candidates. Partly achieved. Background of the topic The power of internal translation via the activity of internal ribosomal entry site (IRES) elements allow coordinated sy
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Firon, Nurit, Prem Chourey, Etan Pressman, Allen Hartwell, and Kenneth J. Boote. Molecular Identification and Characterization of Heat-Stress-Responsive Microgametogenesis Genes in Tomato and Sorghum - A Feasibility Study. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7591741.bard.

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Exposure to higher than optimal temperatures - heat-stress (HS) - is becoming increasingly common to all crop plants worldwide. Heat stress coinciding with microgametogenesis, especially during the post-meiotic phase that is marked by starch biosynthesis, is often associated with starch-deficient pollen and male sterility and ultimately, greatly reduced crop yields. The molecular basis for the high sensitivity of developing pollen grains, on one hand, and factors involved in pollen heat-tolerance, on the other, is poorly understood. The long-term goal of this project is to provide a better und
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Fridman, Eyal, and Eran Pichersky. Tomato Natural Insecticides: Elucidation of the Complex Pathway of Methylketone Biosynthesis. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7696543.bard.

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Abstract:
Plant species synthesize a multitude of specialized compounds 10 help ward off pests. and these in turn may well serve as an alternative to synthetic pesticides to reduce environmental damage and health risks to humans. The general goal of this research was to perform a genetic and biochemical dissection of the natural-insecticides methylketone pathway that is specific to the glandular trichomes of the wild species of tomato, Solanumhabrochaites f. glabratum (accession PI126449). Previous study conducted by us have demonstrated that these compounds are synthesized de novo as a derivate pathway
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