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Dissertations / Theses on the topic 'Mouse Derived Transcription Factors'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Britz, Olivier. "Role of proneural bHLH transcription factors in mouse telencephalic development." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13170.

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Le cerveau des mammifères est constitué de complexes réseaux de neurones associés à deux types de cellules gliales, les astrocytes et les oligodendrocytes. C'est une structure finement organisée dont la formation repose sur la production et le positionnement correct du nombre approprié des divers types cellulaires au cours du développement. Les progéniteurs indifférenciés s'engagent d'abord dans un lignage cellulaire puis se différencient en un sous-type spécifique de cellule. Cette maturation est liée à des changements précis dans l'expression génique, et récemment les facteurs de transcripti

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2

Yuan, Yuan, and 袁媛. "Transcriptional regulation of mouse secretin receptor in hypothalamic cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47752932.

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As a neuropeptide, both secretin and secretin receptor are expressed in the central nervous system (CNS). It has been revealed that the activities of secretin on hypothalamic cells of rodents are important for osmoregulation and food intake. In the present study, embryonic mouse hypothalamic cell line N42 was used to study the promoter activity of mouse secretin receptor (mSR). By 5′ deletion analysis, a promoter element was identified within ?282 to ?443, relative to the ATG codon, and it contains a GC-box (-297 to -286), a ras responsive element (RRE) (-289 to -276) and an E-box (-416 to

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3

Nakaki, Fumio. "Induction of mouse germ-cell fate by transcription factors in vitro." Kyoto University, 2014. http://hdl.handle.net/2433/188684.

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4

Kotova, Irina. "Purification of general RNA polymerase II transcription factors from mouse for studies of proliferation-specific transcription." Doctoral thesis, Umeå : Department of Medical BIochemistry and Biophysics, Umeå University, 2003. http://publications.uu.se/umu/theses/abstract.xsql?dbid=91.

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5

Stoddart, Neil Richard. "A possible role for embryo-derived factors during mouse preimplantation development?" Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295921.

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6

Erickson, Drew Talyn. "Multiple Roles for the Transcription Factors Sox6 and Jumonji in Mouse Hematopoiesis." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195728.

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Sox6, a member of the Sox transcription factor family, is essential for the silencing of epsilon-y-globin gene expression in definitive erythropoiesis of mice and humans. Homozygous Sox6 null mice are neonatal lethal, precluding analysis at later stages. We created adult mice that are deficient in Sox6 specifically in hematopoietic tissues, by transplanting embryonic liver stem cells from Sox6-deficient mice into lethally-irradiated congenic wild-type adult mice. The mice receiving mutant stem cells (mutant-engrafted) showed high expression levels of epsilon-y in bone marrow, spleen and circu

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7

Hlatshwayo, Nkosikhona Rejoyce. "Comparison of protein binding microarray derived and ChIP-seq derived transcription factor binding DNA motifs." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1017907.

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Transcription factors (TFs) are biologically important proteins that interact with transcription machinery and bind DNA regulatory sequences to regulate gene expression by modulating the synthesis of the messenger RNA. The regulatory sequences comprise of short conserved regions of a specific length called motifs . TFs have very diverse roles in different cells and play a very significant role in development. TFs have been associated with carcinogenesis in various tissue types, as well as developmental and hormone response disorders. They may be responsible for the regulation of oncogenes and

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8

Chao, Christina Seng. "The roles of Nkx2.2 in determination of mouse islet cell fates /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Cell & Developmental Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 144-158). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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9

Geng, Yuhong, and 耿雨紅. "Functional studies of SOX9 in mouse development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243071.

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10

Ho, Siu-yin Bryan, and 何兆賢. "Genetic analyses of the roles of Sox2 and Sox18 in mouse hair development and growth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206748.

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The mouse pelage hair consists of three types of hair coined primary (guard), secondary (awls and auchenes) and tertiary (zigzag) hair. They display distinct morphologies and are induced consecutively during hair morphogenesis. Previously two identified regulatory mouse mutants, Yellow submarine (Ysb) and Light coat and circling (Lcc) which the chromosomal rearrangements have disrupted the cis-acting regulatory elements of Sox2; resulting in the loss of Sox2 expression in the inner ear. The mutants displayed lighter hair coat color due to a reduction in the proportion of secondary hair and inc

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11

Chia, Gloryn Le Bin. "Investigating the role of Oct4 during lineage specification in the physiological context of mouse embryonic development." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607990.

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12

Law, Man-lee. "Studying enteric nervous system development using the Sox10[delta]5 mouse mutant." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36762106.

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13

Law, Man-lee, and 羅敏莉. "Studying enteric nervous system development using the Sox10[delta]5 mouse mutant." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3762541X.

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14

Tang, Chung Yiu Jonathan. "CIS-regulatory integration of intrinsic transcription factors with target-derived signals in neuronal differentiation." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24210.

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We now know that expression of the appropriate terminal differentiation gènes (TDG), such as neuropeptides, neurotransmitters, ion channels, etcetera, in maturing neurons is controlled by cell-specific combinations of transcription factors and by signals secreted from the neurons' target cells. However, it is unclear how thèse two regulatory inputs are integrated inside neurons. In Drosophila, target-derived Bone Morphogenetic Protein (BMP) signals and a well-characterized combinatorial code of transcription factors activate expression of the FMRFa gene in the Tv neurons. Here, I performed a c

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15

Grote, David. "The role of Pax2/8 and Gata3 transcription factors during mouse urogenital system development." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66844.

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The urogenital system performs essential functions for life and reproduction in all vertebrate species. In humans, congenital malformations of the urogenital system rank among the most common birth defects and can cause life-threatening complications in adults. Therefore, understanding urogenital system pathogenesis is imperative in order to provide more accurate diagnoses and better medical interventions to ultimately improve clinical outcome in patients. In this regard, my thesis research projects focused on the development of the mouse urogenital system with the aim of adv

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16

Parrott, Justine Nicola. "Expression and function of Rel/NF-κB transcription factors in the early mouse embryo". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627394.

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17

Han, Lu. "Functions of Zinc-finger Transcription Factors Gli and Osr during Foregut Development in Mouse." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504871878955264.

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18

Budry, Lionel. "A transcriptome analysis of mouse pituitary development: implication of Etv1 and Pax7 transcription factors in POMC transcription and cell differentiation." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96892.

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As the key organ in the endocrine system, the pituitary has long been the subject of intense scientific questioning. From the characterization of pituitary hormones to the understanding of the mechanisms controlling their release, the study of the pituitary yielded great discoveries, some being awarded a Nobel prize. More recently, the transcriptional control of genes encoding pituitary hormones was the object of much attention. In that context, our laboratory described the function of Tpit and NeuroD1 in the control of POMC-expressing cell differentiation and POMC cell-specific transcription

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19

Laing, Michael A. "Establishing the role of PEA3 : an ETS family transcription factor, during mouse embryonic development /." *McMaster only, 1998.

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20

Sit, Hon-man, and 薛瀚文. "Studying the role of Sox10 in enteric neural crest cell migration with Sox10NGFP mouse mutant." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206425.

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21

Wang, Yang. "Transcriptional regulation of junctional adhesion molecule-B in mouse testicular cells." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39793990.

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22

Wang, Yang, and 王洋. "Transcriptional regulation of junctional adhesion molecule-B in mouse testicular cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793990.

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23

Li, Bin. "Characterization of C/EBP[delta] mRNA stability regulation in mouse mammary epithelial cell." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1167885575.

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24

Zhang, Yalun, and 张亚伦. "Pax6/c-Myb regulates neuronal apoptosis in a mouse model of Alzheimer's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47331148.

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Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder which is characterized by impaired mental functions such as memory, language, perception, behavior and personality, as well as cognitive skills. The molecular mechanisms underlying this disease is still largely unknown, but numerous evidence emerge to support a cell cycle hypothesis which implicates the deregulation of cell cycle proteins as key mediators of neuronal dysfunction and loss in AD brains. One of these signals in Aβ-induced neuronal death model is Cdk/Rb/E2F pathway, where Aβ insult evokes activation o

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25

Simplicio, Nicolas. "Role of the proneural bHLH transcription factors in the development of the mouse mesencephalic dopaminergic neurons." Université Louis Pasteur (Strasbourg) (1971-2008), 2005. http://www.theses.fr/2005STR13082.

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La compréhension des mécanismes impliqués dans la génération des neurones dopaminergiques du mésencéphale ventral est actuellement partielle. Les données disponibles proviennent principalement d'études de facteurs exprimés dans les cellules postmitotiques mais très peu des précurseurs en division. Une meilleure compréhension des mécanismes de cette neurogénèse est une étape importante vers une possible cure des troubles dans lesquels ces neurones sont impliqués (Parkinson, schizophrénie, dépendance aux drogues). Les gênes proneuraux de type bHLH (basic Helix Loop Helix) sont des régulateurs tr

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26

Delfini, Marcello. "Jun regulates monocyte-derived macrophage accumulation and tumour progression." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0076.

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Les macrophages sont des cellules immunitaires innées présentes dans chaque organe. Ils sont des cibles thérapeutiques dans de nombreuses maladies, dont le cancer. En dépit de travaux récents sur l'origine des macrophages, les mécanismes régulant leur différenciation sont mal définis. L'expression de Jun, membre de la famille AP-1, augmente pendant la différenciation des macrophages, mais son rôle dans ce processus n'est pas connu.Au cours de mon doctorat, nous avons caractérisé le rôle de Jun dans le développement et l'homéostasie des macrophages, dans un modèle de souris avec délétion condit

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27

Matereke, Lavious Tapiwa. "Analysis of predictive power of binding affinity of PBM-derived sequences." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1018666.

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A transcription factor (TF) is a protein that binds to specific DNA sequences as part of the initiation stage of transcription. Various methods of finding these transcription factor binding sites (TFBS) have been developed. In vivo technologies analyze DNA binding regions known to have bound to a TF in a living cell. Most widely used in vivo methods at the moment are chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) and DNase I hypersensitive sites sequencing. In vitro methods derive TFBS based on experiments with TFs and DNA usually in artificial settings or computationally

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28

Malampati, Sandeep. "Study of a novel curcumin-derived TFEB activator C1 on experimental alzheimer's disease." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/720.

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Autophagy is the major cellular, conservative, lysosomal catabolic process to eliminate and recycle intracellular waste and organelles through autophagosomes. Enhancing autophagy to promote the clearance of toxic proteins is developing as a promising approach to treat proteinopathy disorders like Alzheimer's disease (AD). AD is the most common aging-associated neurodegenerative disease. It is characterized by the aggregation of aberrantly hyperphosphorylated tau (p-Tau) and excessively produced Amyloid-beta (Aβ) into neurofibrillary tangles (NFTs), and amyloid plaques (AP) respectively. Reprog

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29

Holmqvist, Per-Henrik. "Transcription factor effects on chromatin organisation and gene regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-453-8/.

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30

Lioubinski, Oleg. "Roles of HMG-box transcription factors in the pancreas development of the mouse (mus musculus, Linnaeus, 1758)." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972624473.

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31

Paul, Mandy [Verfasser], and Michael [Akademischer Betreuer] Wegner. "The role of transcription factors Sox4 and Sox11 in mouse heart development / Mandy Paul. Gutachter: Michael Wegner." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1075834171/34.

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32

Alhashem, Yousef N. "REGULATION OF THE MOUSE AND HUMAN β-GLOBIN GENES BY KRÜPPEL LIKE TRANSCRIPTION FACTORS KLF1 AND KLF2". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2927.

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Krüppel-like factors KLF1 and KLF2 are closely related transcription factors with three zinc finger domains in their carboxy-termini. KLF1 (erythroid Krüppel-like factor, or EKLF) plays essential roles in embryonic and adult erythropoiesis. KLF2 is a positive regulator of the mouse and human embryonic β- globin genes. KLF1 and KLF2 have overlapping roles in embryonic erythropoiesis, as demonstrated using single and double knockout (KO) mouse models. Ablation of the KLF1 or KLF2 gene causes embryonic lethality, and double KO embryos are more anemic and die sooner than either single KO. We have

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33

Vinjamur, Divya. "The Roles of Krüppel-like Transcription Factors KLF1 and KLF2 in Mouse Embryonic and Human Fetal Erythropoiesis." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/630.

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Hemoglobinopathies are some of the most common monogenic disorders in the world, affecting millions of people and representing a growing burden on health systems worldwide. Although the pathophysiology of sickle cell anemia and beta-thalassemia, two of the most common hemoglobinopathies, have been the focus of much research over the last century, patients affected by these diseases still lack a widely applicable and easily available cure. Sickle cell anemia and beta-thalassemia are caused by defects in the structure and production of the beta-globin chains that, along with the alpha-globin cha

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34

Alrefai, Hani Gouda Alsaid [Verfasser], and Edgar [Gutachter] Serfling. "Molecular Characterization of NFAT Transcription Factors in Experimental Mouse Models / Hani Gouda Alsaid Alrefai. Gutachter: Edgar Serfling." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1108780784/34.

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35

Gozdecka, Malgorzata. "The role of transcription factors ATF2 and ATF7 in hepatocellular carcinoma : an investigation employing genetic mouse models." Thesis, University of Manchester, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532210.

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36

Zhang, Mei, and 章梅. "A Sox10-GFP mutant mouse model for the study of abnormal enteric nervous system development in Hirschsprung disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45900504.

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37

Williams, Helen. "Investigation of the metabolic functions of Klf3 and Klf8 using mouse models." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/28935.

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Obesity is a disease characterised by an excess of white adipose tissue. It leads to increased risk of several associated disorders including cardiovascular disease and type 2 diabetes mellitus. The number of people who are obese is increasing worldwide and as such much research is conducted on obesity and associated disorders. The use of animal models in the study of obesity allows understanding of involvement of specific genes in fat formation and related processes. This can be used to identify targets for prevention or treatment of obesity. Kriippel—like factors are a family of tra

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38

Zhu, Shun-Wei. "Brain neurotrophin levels and mouse behavior : relationship to environmental influences /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-843-6/.

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39

Lowenstein, Marcia. "Interactions between Endothelin Receptor B and Transcription Factors Sox10 and Pax3 in the Melanocyte Lineage." FIU Digital Commons, 2009. http://digitalcommons.fiu.edu/etd/117.

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Genetic interactions that underlie developmental processes such as cell differentiation and pattern formation are complex and difficult to elucidate. Neural Crest (NC) cells and their derivatives offer an optimal system in which to probe for these complex interactions as they acquire different cell fates and constitute a variety of structures. The transcription factors Sox10 and Pax3 as well as the transmembrane receptor Endothelin receptor b (Ednrb) are temporally and spatially co-expressed early in NC cells and mutations in these genes lead to similar hypopigmentation phenotypes due to a red

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40

Matsuura, Rie, Hiroshi Kogo, Takunori Ogaeri, et al. "Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells." Alpha Med Press, 2006. http://hdl.handle.net/2237/7444.

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41

Iki, Takehiro. "Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres." Kyoto University, 2018. http://hdl.handle.net/2433/232071.

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42

O'Leary, Debra Alison. "Characterisation of gene structure and function of the ETS transcription factor Gabpα in mouse". Monash University, Centre for Functional Genomics and Human Disease, 2003. http://arrow.monash.edu.au/hdl/1959.1/9445.

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43

Yu, Elizabeth A. "Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/544.

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Ectopic calcification can cause pain and limit mobility. Studies suggest that circadian genes may play a role in the calcification process. Core circadian genes Clock, Npas2, and Bmal1 are transcription factors that form CLOCK:BMAL1 or NPAS2:BMAL1 transactivator complexes that drive the rhythmic expression of circadian oscillator genes and output genes. Circadian oscillator genes Period1-3 and Cryptochrome1-2 encode proteins that form transcription repressor complexes that feedback to inhibit CLOCK/NPAS2:BMAL1 activity, thus completing the feedback loop that is the basis of the molecular circa

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44

Massumi, Mohammad. "Directed Differentiation of ES cells by pancreatic transcription factors p48, RBPJL and Mist1." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7231.

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A pesar de la abundancia de estudios realizados sobre el papel de las células acinares en las patologías exocrinas del páncreas (i.e. pancreatitis y cáncer), el estudio de las modificaciones producidas durante la diferenciación acinar en dichas patologías, se ha visto limitado por la escasez de modelos celulares no tumorales. Resultados previos de nuestro laboratorio, muestran que las células mES (células madre embrionarias de ratón )- pluripotentes y con la capacidad para generar tipos celulares especializados- pueden desarrollar un fenotipo acinar in vitro. Los objetivos de esta tesis han si

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45

Fair, Joel Vincent. "Gli2 Accelerates Cardiac Progenitor Gene Expression During Mouse Embryonic Stem Cell Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31579.

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The Hedgehog (HH) signalling pathway and its primary transducer, GLI2, regulate cardiomyogenesis in vivo and in differentiating P19 embryonal carcinoma (EC) cells. To further assess the role of HH signalling during mouse embryonic stem (mES) cell differentiation, we studied the effects of GLI2 overexpression during mES cell differentiation. GLI2 overexpression resulted in temporal enhancement of cardiac progenitor genes, Mef2c and Nkx2-5, along with enhancement of Tbx5, Myhc6, and Myhc7 in day 6 differentiating mES cells. Mass spectrometric analysis of proteins that immunoprecipitate with GLI2

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46

Yang, Cheng-Tao. "Manipulating transcription factors in human induced pluripotent cell-derived cells to enhance the production and the maturation of red blood cells." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28928.

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The most widely transfused blood component is red blood cells (RBCs), and voluntary donation is the main resource for RBC transfusion. In the UK, 7,000 units of RBCs are transfused daily but this life-saving cell therapy is completely dependent on donors and there are persistent problems associated with transfusion transmitted infections and in blood group compatibility. Furthermore, the quality, safety and efficiency of donated RBCs gradually decrease with storage time. A number of novel sources of RBCs are being explored including the production of RBCs from adult haematopoietic progenitor c

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47

Torihashi, Shigeko, Masaki Kuwahara, and Masaaki Kurahashi. "In Vitro Developmental Model of the Gastrointestinal Tract from Mouse Embryonic Stem Cells." Nagoya University School of Medicine, 2007. http://hdl.handle.net/2237/9187.

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48

Préfontaine, Gratien G. "Selective binding of steroid receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter: A molecular mechanism for transcription factor recruitment to promoter DNA." Thesis, University of Ottawa (Canada), 2001. http://hdl.handle.net/10393/9111.

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The glucocorticoid receptor (GR) and octamer transcription factors -1 and -2 (Oct -1/-2) function synergistically to activate gene transcription from the Mouse Mammary Tumor Virus (MMTV) promoter. Mechanisms responsible for the transcriptional synergy have not been characterized. I demonstrated a protein-protein interaction between rat GR and human Oct-1/-2 in vivo, and showed the interaction was sensitive to GR point mutations C500Y and L501P. This interaction correlated with the recruitment of Oct-l/-2 to promoter DNA and appeared to contribute at least in part to the transcriptional synergy

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49

Partanen, Maija Elina. "Expression of the transcriptional cofactors/histone acetyltransferases CBP and P300 during mouse development and their functional interactions with Gli transcription factors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58627.pdf.

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50

Jasinski, Jean Marie. "Simplification of the immunogenetics of type 1A diabetes through transgenic T cell receptor mouse models /." Connect to abstract via ProQuest. Full text is not available online, 2008.

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