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Journal articles on the topic 'Mouse Derived Transcription Factors'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Maeda, K., M. Nakashima, S. Komori, and T. Watanabe. "Trans-acting regulatory factors for T cell antigen receptor alpha- and gamma-chain gene expression." Journal of Immunology 140, no. 8 (1988): 2796–801. http://dx.doi.org/10.4049/jimmunol.140.8.2796.

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Abstract BALB/c mouse thymoma-derived T cell line, CAK4.4 (Thy-1+, L3T4-, Lyt-2-), produced a large amount of TCR-gamma mRNA, a trace amount of TCR-beta mRNA but no detectable level of TCR-alpha mRNA. Another BALB/c mouse thymoma-derived T cell line, CAK1.3 (Thy-1+, L3T4+, Lyt-2+), synthesized a high level of TCR-alpha as well as TCR-beta mRNA but did not produce any amount of TCR-gamma mRNA. HAT-sensitive clones were established from the two T cell lines. Azaguanine-resistant, HPRT- CAK4.4 cells and bromodeoxyuridine-resistant, TK- CAK1.3 cells were fused by electrofusion method and the resul

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2

Costa, Robert H., Vladimir V. Kalinichenko, and Lorena Lim. "Transcription factors in mouse lung development and function." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 5 (2001): L823—L838. http://dx.doi.org/10.1152/ajplung.2001.280.5.l823.

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Development of the mouse lung initiates on day 9.5postcoitum from the laryngotracheal groove and involves mesenchymal-epithelial interactions, in particular, those between the splanchnic mesoderm and epithelial cells (derived from foregut endoderm) that induce cellular proliferation, migration, and differentiation, resulting in branching morphogenesis. This developmental process mediates formation of the pulmonary bronchiole tree and integrates a terminal alveolar region with an extensive endothelial capillary bed, which facilitates efficient gas exchange with the circulatory system. The major

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3

Gray, Paul A. "Transcription factors and the genetic organization of brain stem respiratory neurons." Journal of Applied Physiology 104, no. 5 (2008): 1513–21. http://dx.doi.org/10.1152/japplphysiol.01383.2007.

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Breathing is a genetically determined behavior generated by neurons in the brain stem. Transcription factors, in part, determine the basic developmental identity of neurons, but the relationships between these genes and the neural populations generating and modulating respiration are unclear. The diversity of brain stem populations has been proposed to result from a combinatorial code of transcription factor expression corresponding to the anterior-posterior (A-P) and dorsal-ventral (D-V) location of a neuron's birth. I provide a schematic of transcription factor coding identifying at least 15

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4

Kaarbø, Mari, Denis I. Crane, and Wayne G. Murrell. "RhoA Regulation of Cardiomyocyte Differentiation." Scientific World Journal 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/491546.

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Earlier findings from our laboratory implicated RhoA in heart developmental processes. To investigate factors that potentially regulate RhoA expression, RhoA gene organisation and promoter activity were analysed. Comparative analysis indicated strict conservation of both gene organisation and coding sequence of the chick, mouse, and human RhoA genes. Bioinformatics analysis of the derived promoter region of mouse RhoA identified putative consensus sequence binding sites for several transcription factors involved in heart formation and organogenesis generally. Using luciferase reporter assays,

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5

Boucher, DM, and RA Pedersen. "Induction and differentiation of extra-embryonic mesoderm in the mouse." Reproduction, Fertility and Development 8, no. 4 (1996): 765. http://dx.doi.org/10.1071/rd9960765.

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Extra-embryonic mesoderm, derived at the time of gastrulation from the primitive streak, gives rise to several tissues that function to provide the embryo with nutrients, a means of waste disposal, and mechanical protection. Little is known about the differentiation of this tissue and about the growth and transcription factors involved. The present review focussed on growth and transcription factors that may be involved in differentiation of extra-embryonic mesoderm, and results from fate-mapping and transplantation studies. Methods in vitro available for assaying the effects of growth and tra

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6

Maeda, Yutaka, Vrushank Davé, and Jeffrey A. Whitsett. "Transcriptional Control of Lung Morphogenesis." Physiological Reviews 87, no. 1 (2007): 219–44. http://dx.doi.org/10.1152/physrev.00028.2006.

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The vertebrate lung consists of multiple cell types that are derived primarily from endodermal and mesodermal compartments of the early embryo. The process of pulmonary organogenesis requires the generation of precise signaling centers that are linked to transcriptional programs that, in turn, regulate cell numbers, differentiation, and behavior, as branching morphogenesis and alveolarization proceed. This review summarizes knowledge regarding the expression and proposed roles of transcription factors influencing lung formation and function with particular focus on knowledge derived from the s

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7

Song, Shuang, Chun Cao, Mohamed-Amin Choukrallah, et al. "OBF1 and Oct factors control the germinal center transcriptional program." Blood 137, no. 21 (2021): 2920–34. http://dx.doi.org/10.1182/blood.2020010175.

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Abstract OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell–specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here, we show by chromatin immunoprecipitation-sequencing that OBF1 extensively colocalizes with OCT1 and OCT2. We found that these factors also often colocalize with transcription factors of the ETS family. Furthermore, we showed that OBF1, OCT2, and OCT1 bind widely to the promoters or enhancers of genes involved in GC formation in mouse and human GC B cells. Short hairp

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8

Woodward, J. G., K. W. Omer, and P. M. Stuart. "MHC class II transcription in different mouse cell types. Differential requirement for protein synthesis between B cells and macrophages." Journal of Immunology 142, no. 11 (1989): 4062–69. http://dx.doi.org/10.4049/jimmunol.142.11.4062.

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Abstract Although the MHC class II genes are known to be regulated transcriptionally, the relative rates of transcription of the four classical class II genes in different cell types have not been investigated. Using nuclear transcriptional analysis, we have investigated the transcriptional rates of the class II genes in the macrophage cell line WEHI-3, normal bone marrow-derived macrophages, L-929 cells, and two different B cell lymphoma lines. Kinetic analysis of class II transcription in IFN-gamma-treated WEHI-3 cells revealed a 4-h delay, followed by a rapid increase in transcription over

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Almendral, J. M., D. Sommer, H. Macdonald-Bravo, J. Burckhardt, J. Perera, and R. Bravo. "Complexity of the early genetic response to growth factors in mouse fibroblasts." Molecular and Cellular Biology 8, no. 5 (1988): 2140–48. http://dx.doi.org/10.1128/mcb.8.5.2140-2148.1988.

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Genes whose expression is growth factor regulated are likely to be important components in the mechanisms controlling cell proliferation and differentiation. With the aim of identifying some of those genes, a lambda cDNA library was prepared with poly(A)+ RNA from quiescent NIH 3T3 cells stimulated with serum for 4 h in the presence of cycloheximide. Differential screening of approximately 200,000 recombinant phage plaques revealed 2,540 clones that cross hybridized preferentially with [32P]cDNA derived from RNA of stimulated cells rather than with cDNA derived from nonstimulated cells. Cross

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Almendral, J. M., D. Sommer, H. Macdonald-Bravo, J. Burckhardt, J. Perera, and R. Bravo. "Complexity of the early genetic response to growth factors in mouse fibroblasts." Molecular and Cellular Biology 8, no. 5 (1988): 2140–48. http://dx.doi.org/10.1128/mcb.8.5.2140.

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Genes whose expression is growth factor regulated are likely to be important components in the mechanisms controlling cell proliferation and differentiation. With the aim of identifying some of those genes, a lambda cDNA library was prepared with poly(A)+ RNA from quiescent NIH 3T3 cells stimulated with serum for 4 h in the presence of cycloheximide. Differential screening of approximately 200,000 recombinant phage plaques revealed 2,540 clones that cross hybridized preferentially with [32P]cDNA derived from RNA of stimulated cells rather than with cDNA derived from nonstimulated cells. Cross

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11

Chen, Rui, and Thomas Skutella. "Tendon-Specific Activation of Tenogenic Transcription Factors Enables Keeping Tenocytes’ Identity In Vitro." International Journal of Molecular Sciences 23, no. 22 (2022): 14078. http://dx.doi.org/10.3390/ijms232214078.

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We generated a novel tetracycline-inducible transgenic mouse line with the tendon-specific expression of a series of tendon-critical transcription factors. Primary tenocytes derived from this mouse line consistently expressed green fluorescent protein reporter transcription factors in response to doxycycline. The tenocytes maintained their tendon cell properties for a longer time after the transient induction in the absence of growth factors and mechanical stress. Four key transcription factors for tendon development and the green fluorescent protein reporter were linked with different viral 2

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Knoedler, Joseph R., José Ávila-Mendoza, Arasakumar Subramani, and Robert J. Denver. "The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp." Journal of Biological Rhythms 35, no. 3 (2020): 257–74. http://dx.doi.org/10.1177/0748730420913205.

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An intricate transcription-translation feedback loop (TTFL) governs cellular circadian rhythms in mammals. Here, we report that the zinc finger transcription factor Krüppel-like factor 9 (KLF9) is regulated by this TTFL, it associates in chromatin at the core circadian clock and clock-output genes, and it acts to modulate transcription of the clock-output gene Dbp. Our earlier genome-wide analysis of the mouse hippocampus-derived cell line HT22 showed that KLF9 associates in chromatin with Per1, Per3, Dbp, Tef, Bhlhe40, Bhlhe41, Nr1d1, and Nr1d2. Of the 3514 KLF9 peaks identified in HT22 cells

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Zhao, Minglian, Vandana Gupta, Lakshmi Raj, Martine Roussel, and Marianna Bei. "A Network of Transcription Factors Operates during Early Tooth Morphogenesis." Molecular and Cellular Biology 33, no. 16 (2013): 3099–112. http://dx.doi.org/10.1128/mcb.00524-13.

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Improving the knowledge of disease-causing genes is a unique challenge in human health. Although it is known that genes causing similar diseases tend to lie close to one another in a network of protein-protein or functional interactions, the identification of these protein-protein networks is difficult to unravel. Here, we show that Msx1, Snail, Lhx6, Lhx8, Sp3, and Lef1 interactin vitroandin vivo, revealing the existence of a novel context-specific protein network. These proteins are all expressed in the neural crest-derived dental mesenchyme and cause tooth agenesis disorder when mutated in

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Oh, Kyu Seon, Jisu Ha, Songjoon Baek, and Myong-Hee Sung. "XL-DNase-seq: Improved footprinting of dynamic transcription factors." Journal of Immunology 202, no. 1_Supplement (2019): 125.17. http://dx.doi.org/10.4049/jimmunol.202.supp.125.17.

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Abstract As the cost of high-throughput sequencing technologies decreases, genome-wide chromatin accessibility profiling methods such as the assay of transposase-accessible chromatin using sequencing (ATAC-seq) are employed widely, with data accumulating at an unprecedented rate. However, accurate inference of protein occupancy requires higher resolution footprinting analysis where major hurdles exist, including the sequence bias of nucleases and the short-lived chromatin binding of many transcription factors (TFs) with consequent lack of footprints. Here we introduce an assay termed crosslink

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15

Mouzaki, A., R. H. Zubler, A. Doucet, and D. Rungger. "Trans-active factors controlling the IL-2 gene in adult human T-cell subsets." Mediators of Inflammation 1, no. 1 (1992): 33–37. http://dx.doi.org/10.1155/s0962935192000073.

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IL-2 secretion in total or subsets of PHA/PMA-stimulated PBMC-derived human T-lymphocytes was monitored and found to be largely due to CD4+CD8−cells. The presence and functional state of transcription factors (TF) was assessed by protein-DNA interaction assays and functional transactivation experiments in the Xenopts oocyte system, modulating IL-2 transcription by injection of proteins. The results reveal that CD4+CD8−cells contain both, functional silencer in their resting, and positive TF in their activated states while the CD4+CD8−group contains only non-functional positive TF. This demonst

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Cox, Luke S., Marisol Alvarez-Martinez, Xuemei Wu, et al. "Blimp-1 and c-Maf regulate Il10 and negatively regulate common and unique proinflammatory gene networks in IL-12 plus IL-27-driven T helper-1 cells." Wellcome Open Research 8 (December 1, 2023): 403. http://dx.doi.org/10.12688/wellcomeopenres.19680.2.

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Background CD4+ Th1 cells producing IFN-γ are required to eradicate intracellular pathogens, however if uncontrolled these cells can cause immunopathology. The cytokine IL-10 is produced by multiple immune cells including Th1 cells during infection and regulates the immune response to minimise collateral host damage. In this study we aimed to elucidate the transcriptional network of genes controlling the expression of Il10 and proinflammatory cytokines, including Ifng in Th1 cells differentiated from mouse naive CD4+ T cells. Methods We applied computational analysis of gene regulation derived

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Fernandez, Natalie, Heather Renna, Lauren McHugh, Katie Mazolkova, William Crugnola, and Jodi F. Evans. "Mouse Mesenchymal Progenitor Cells Expressing Adipogenic and Osteogenic Transcription Factors Suppress the Macrophage Inflammatory Response." Stem Cells International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5846257.

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Mesenchymal progenitor cell characteristics that can identify progenitor populations with specific functions in immunity are actively being investigated. Progenitors from bone marrow and adipose tissue regulate the macrophage (MΦ) inflammatory response by promoting the switch from an inflammatory to an anti-inflammatory phenotype. Conversely, mesenchymal progenitors from the mouse aorta (mAo) support and contribute to the MΦ response under inflammatory conditions. We used cell lines with purported opposing immune-regulatory function, a bone marrow derived mesenchymal progenitor cell line (D1)

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18

Ng, Y. K., K. M. George, J. D. Engel, and D. I. Linzer. "GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene." Development 120, no. 11 (1994): 3257–66. http://dx.doi.org/10.1242/dev.120.11.3257.

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The molecular determinants governing tissue-specific gene expression in the placenta are at present only poorly defined, particularly with respect to the regulation of specific hormone genes whose products are vital to embryonic development and the maintenance of a nurturing maternal environment. In continuing our analysis of the trophoblast-specific expression of the mouse placental lactogen I gene, we now demonstrate that the transcription factors GATA-2 and GATA-3 regulate the activity of this gene promoter. These factors are expressed in placental trophoblast cells, with peak levels of the

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19

Pan, Li, Yanping Wang, Craig A. Jones, Sean T. Glenn, Heinz Baumann, and Kenneth W. Gross. "Enhancer-dependent inhibition of mouse renin transcription by inflammatory cytokines." American Journal of Physiology-Renal Physiology 288, no. 1 (2005): F117—F124. http://dx.doi.org/10.1152/ajprenal.00333.2003.

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Inflammatory cytokines have been shown to inhibit renin gene expression in the kidney in vivo and the kidney tumor-derived As4.1 cell line. In this report, we show that cytokines oncostatin M (OSM), IL-6, and IL-1β inhibit transcriptional activity associated with 4.1 kb of the mouse renin 5′-flanking sequence in As4.1 cells. The 242-bp enhancer (−2866 to −2625 bp) is sufficient to mediate the observed inhibitory effects. Sequences within the enhancer required for inhibition by each of these cytokines have been determined by deletional and mutational analysis. Results indicate that a 39-bp regi

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Remenyi, Judit, Christopher J. Hunter, Christian Cole, et al. "Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins." Biochemical Journal 428, no. 2 (2010): 281–91. http://dx.doi.org/10.1042/bj20100024.

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Neurotrophins are growth factors that are important in neuronal development and survival as well as synapse formation and plasticity. Many of the effects of neurotrophins are mediated by changes in protein expression as a result of altered transcription or translation. To determine whether neurotrophins regulate the production of microRNAs (miRNAs), small RNA species that modulate protein translation or mRNA stability, we used deep sequencing to identify BDNF (brain-derived neurotrophic factor)-induced miRNAs in cultured primary cortical mouse neurons. This revealed that the miR-212/132 cluste

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Barthet, Valentin J. A., Martina Brucoli, Marcus J. G. W. Ladds, et al. "Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver." Science Advances 7, no. 23 (2021): eabf9141. http://dx.doi.org/10.1126/sciadv.abf9141.

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Hepatocellular carcinoma (HCC) is driven by repeated rounds of inflammation, leading to fibrosis, cirrhosis, and, ultimately, cancer. A critical step in HCC formation is the transition from fibrosis to cirrhosis, which is associated with a change in the liver parenchyma called ductular reaction. Here, we report a genetically engineered mouse model of HCC driven by loss of macroautophagy and hemizygosity of phosphatase and tensin homolog, which develops HCC involving ductular reaction. We show through lineage tracing that, following loss of autophagy, mature hepatocytes dedifferentiate into bil

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Ohneda, Ohmori, and Yamamoto. "Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells." International Journal of Molecular Sciences 20, no. 18 (2019): 4603. http://dx.doi.org/10.3390/ijms20184603.

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Mast cell tryptases have crucial roles in allergic and inflammatory diseases. The mouse tryptase genes represent a cluster of loci on chromosome 16p3.3. While their functional studies have been extensively performed, transcriptional regulation of tryptase genes is poorly understood. In this study, we examined the molecular basis of the tryptase gene expression in bone marrow-derived mast cells (BMMCs) of C57BL/6 mice and in MEDMC-BRC6 mast cells. The expression of the Tpsb2 and Tpsg1 genes, which reside at the 3′-end of the tryptase locus, is significantly decreased by the reduction of the GAT

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Schiffmacher, A. T., and C. L. Keefer. "113 CHARACTERIZATION OF THE BOVINE EMBRYO-DERIVED CT-1 CELL LINE FOR STUDYING REGULATION OF TRANSCRIPTION FACTORS EXPRESSED WITHIN THE BOVINE TROPHECTODERM." Reproduction, Fertility and Development 20, no. 1 (2008): 136. http://dx.doi.org/10.1071/rdv20n1ab113.

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Cloned bovine embryos have been shown to display deviations in gene expression of trophectodermal (TE) lineage-specific transcription factors, including Cdx2, Errβ, Eomes, Mash2, and Hand1. Misregulation of these genes in the early TE has been implicated to play a causal role in abnormal placental formation and fetal loss. Because suboptimal in vitro culture conditions fail to support development beyond hatching, very little is known about regulation of peri-attachment bovine embryo development. Trophectodermal-derived bovine cell lines, such as the CT-1 cell line produced by Talbot and collea

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Park, Junseong, Jin-Kyoung Shim, Jae Eun Lee, et al. "ANGI-01. IDENTIFICATION OF INVASION-DETERMINISTIC TRANSCRIPTION FACTORS IN GLIOBLASTOMA USING INTEGRATIVE TRANSCRIPTOME ANALYSIS." Neuro-Oncology 21, Supplement_6 (2019): vi30. http://dx.doi.org/10.1093/neuonc/noz175.112.

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Abstract Glioblastoma (GBM) is one of the most lethal human tumors with a highly infiltrative phenotype. Although invasiveness is related to poor prognosis, no therapeutic intervention targeting invasion is available for treatment of GBM patient, partially due to the diversity and redundancy of invasion machinery genes. In this regard, additional identification of deterministic and causative targets for invasion is required. Invasiveness of GBM patients and matched tumorspheres (TSs) was quantified using MR images and collagen-based 3D invasion assays, respectively. Transcriptome of GBM sample

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ZELKO, Igor N., and Rodney J. FOLZ. "Myeloid zinc finger (MZF)-like, Kruppel-like and Ets families of transcription factors determine the cell-specific expression of mouse extracellular superoxide dismutase." Biochemical Journal 369, no. 2 (2003): 375–86. http://dx.doi.org/10.1042/bj20021431.

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Extracellular superoxide dismutase (EC-SOD or SOD3) is an important protective enzyme against the toxicity of superoxide radicals that are produced under both physiological and pathophysiological conditions. We have isolated and characterized over 11kb of the mouse EC-SOD gene and its 5′- and 3′-flanking regions. The gene consists of two exons, with the entire coding region located within exon 2. In order to study the mechanism of cell-specific gene regulation for mouse EC-SOD, we characterized 2500bp of its 5′-flanking region using cultured cells derived from mouse lung fibroblasts (MLg), kid

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Katz, A., and C. Kahana. "Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth." Molecular and Cellular Biology 7, no. 7 (1987): 2641–43. http://dx.doi.org/10.1128/mcb.7.7.2641-2643.1987.

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Cloned ornithine decarboxylase (ODC) (EC 4.1.1.17) cDNA was used to investigate the mechanisms which mediate the mitogenic induction of mammalian ODC. Stimulation of quiescent BALB/c 3T3 mouse fibroblasts with purified fibroblast and platelet-derived growth factors and with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate results in a rapid and dramatic increase in ODC mRNA, similar to the increase caused by serum stimulation. Using nuclear runoff transcriptional analysis, we demonstrate that an increase in ODC transcription accounts for the mitogenic induction of ODC mRNA, and using cy

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Katz, A., and C. Kahana. "Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth." Molecular and Cellular Biology 7, no. 7 (1987): 2641–43. http://dx.doi.org/10.1128/mcb.7.7.2641.

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Cloned ornithine decarboxylase (ODC) (EC 4.1.1.17) cDNA was used to investigate the mechanisms which mediate the mitogenic induction of mammalian ODC. Stimulation of quiescent BALB/c 3T3 mouse fibroblasts with purified fibroblast and platelet-derived growth factors and with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate results in a rapid and dramatic increase in ODC mRNA, similar to the increase caused by serum stimulation. Using nuclear runoff transcriptional analysis, we demonstrate that an increase in ODC transcription accounts for the mitogenic induction of ODC mRNA, and using cy

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Arceci, R. J., A. A. King, M. C. Simon, S. H. Orkin, and D. B. Wilson. "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart." Molecular and Cellular Biology 13, no. 4 (1993): 2235–46. http://dx.doi.org/10.1128/mcb.13.4.2235-2246.1993.

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We report the cDNA cloning and characterization of mouse GATA-4, a new member of the family of zinc finger transcription factors that bind a core GATA motif. GATA-4 cDNA was identified by screening a 6.5-day mouse embryo library with oligonucleotide probes corresponding to a highly conserved region of the finger domains. Like other proteins of the family, GATA-4 is approximately 50 kDa in size and contains two zinc finger domains of the form C-X-N-C-(X17)-C-N-X-C. Cotransfection assays in heterologous cells demonstrate that GATA-4 trans activates reporter constructs containing GATA promoter el

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Arceci, R. J., A. A. King, M. C. Simon, S. H. Orkin, and D. B. Wilson. "Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart." Molecular and Cellular Biology 13, no. 4 (1993): 2235–46. http://dx.doi.org/10.1128/mcb.13.4.2235.

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We report the cDNA cloning and characterization of mouse GATA-4, a new member of the family of zinc finger transcription factors that bind a core GATA motif. GATA-4 cDNA was identified by screening a 6.5-day mouse embryo library with oligonucleotide probes corresponding to a highly conserved region of the finger domains. Like other proteins of the family, GATA-4 is approximately 50 kDa in size and contains two zinc finger domains of the form C-X-N-C-(X17)-C-N-X-C. Cotransfection assays in heterologous cells demonstrate that GATA-4 trans activates reporter constructs containing GATA promoter el

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Thomas, Graham D., Dominik Rückerl, Benjamin H. Maskrey, Phillip D. Whitfield, Mark L. Blaxter та Judith E. Allen. "The biology of nematode- and IL4Rα-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics". Blood 120, № 25 (2012): e93-e104. http://dx.doi.org/10.1182/blood-2012-07-442640.

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Abstract Alternatively activated macrophages (AAMφ) are a major component of the response to helminth infection; however, their functions remain poorly defined. To better understand the helminth-induced AAMφ phenotype, we performed a systems-level analysis of in vivo derived AAMφ using an established mouse model. With next-generation RNA sequencing, we characterized the transcriptomes of peritoneal macrophages from BALB/c and IL4Rα−/− mice elicited by the nematode Brugia malayi, or via intraperitoneal thioglycollate injection. We defined expression profiles of AAMφ-associated cytokines, chemok

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Kaplan, Barbara L. F., and Norbert E. Kaminski. "Nuclear Factor of Activated T Cells (NFAT) is Suppressed by the Plant-Derived Cannabinoid, Cannabidiol. (94.23)." Journal of Immunology 178, no. 1_Supplement (2007): S175. http://dx.doi.org/10.4049/jimmunol.178.supp.94.23.

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Abstract Marijuana is derived from the Cannabis Sativa plant. Although there are over 60 cannabinoid compounds in the plant, Δ9-tetrahydrocannabinol (THC) is the primary psychoactive congener of marijuana and binds to the two known cannabinoid receptors, CB1 and CB2. THC has exhibited immunosuppressive actions both in vivo and in vitro. Interestingly, another predominant cannabinoid from the plant, cannabidiol (CBD), possesses low affinity for both cannabinoid receptors, yet also exhibits immunosuppressive actions. A major target of immune suppression by CBD is interleukin-2 (IL-2) as demonstr

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Chopra, Ria, and Franky Leung Chan. "Abstract 1456: An expression study of circadian clock-associated transcription factors and nuclear receptors in mouse prostate gland and tumor." Cancer Research 83, no. 7_Supplement (2023): 1456. http://dx.doi.org/10.1158/1538-7445.am2023-1456.

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Abstract The circadian clock lies in the suprachiasmatic nucleus of the hypothalamus and is regulated directly by the daily light/dark cycles, generating rhythmic expression of core circadian-controlled genes (CCCG) some belonging to the nuclear receptors (NR) superfamily. Recent advances show that the disruption of the circadian clock is identified as a risk factor for endocrine cancers, such as prostate cancer which is the most common hormone-related male cancer globally. Whether the prostate gland has its own circadian expression of CCCG and NR, and how the dysregulated circadian clock woul

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Diaw, Sokhna Haissatou, Fabian Ott, Alexander Münchau, Katja Lohmann, and Hauke Busch. "Emerging role of a systems biology approach to elucidate factors of reduced penetrance: transcriptional changes in THAP1-linked dystonia as an example." Medizinische Genetik 34, no. 2 (2022): 131–41. http://dx.doi.org/10.1515/medgen-2022-2126.

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Abstract Pathogenic variants in THAP1 can cause dystonia with a penetrance of about 50 %. The underlying mechanisms are unknown and can be considered as means of endogenous disease protection. Since THAP1 encodes a transcription factor, drivers of this variability putatively act at the transcriptome level. Several transcriptome studies tried to elucidate THAP1 function in diverse cellular and mouse models, including mutation carrier-derived cells and iPSC-derived neurons, unveiling various differentially expressed genes and affected pathways. These include nervous system development, dopamine

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Cheng, Alan, Mei Zhang, Sean M. Crosson, Zhao Q. Bao, and Alan R. Saltiel. "Regulation of the Mouse Protein Targeting to Glycogen (PTG) Promoter by the FoxA2 Forkhead Protein and by 3′,5′-Cyclic Adenosine 5′-Monophosphate in H4IIE Hepatoma Cells." Endocrinology 147, no. 7 (2006): 3606–12. http://dx.doi.org/10.1210/en.2005-1513.

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The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2 binding sites within this region. FoxA2 is a member of the forkhead family of transcription factors that has recently been implicated in the cAMP-dependent regulation of several genes involved in liver metabolism. Using luciferase reporter constructs, we demonstrate that FoxA2 tr

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Robek, Michael D., and Lee Ratner. "Immortalization of CD4+ and CD8+ T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone." Journal of Virology 73, no. 6 (1999): 4856–65. http://dx.doi.org/10.1128/jvi.73.6.4856-4865.1999.

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ABSTRACT The human T-cell leukemia virus type 1 (HTLV-1) transcriptionaltrans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models. In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors, Tax activates the expression of multiple cellular promoters through the NF-κB pathway of transcriptional activation. The Tax mutants M22 and M47 have previously been demonstrated to select

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Ma, Haiting, Katherine J. Wert, Dmitry Shvartsman, Douglas A. Melton та Rudolf Jaenisch. "Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas". Proceedings of the National Academy of Sciences 115, № 15 (2018): 3924–29. http://dx.doi.org/10.1073/pnas.1702059115.

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Type 1 diabetes is characterized by autoimmune destruction of β cells located in pancreatic islets. However, tractable in vivo models of human pancreatic β cells have been limited. Here, we generated xenogeneic human pancreatic β-like cells in the mouse pancreas by orthotopic transplantation of stem cell-derived β (SC-β) cells into the pancreas of neonatal mice. The engrafted β-like cells expressed β cell transcription factors and markers associated with functional maturity. Engrafted human cells recruited mouse endothelial cells, suggesting functional integration. Human insulin was detected i

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Crowe, Alison J., Julie L. Piechan, Ling Sang, and Michelle C. Barton. "S-Phase Progression Mediates Activation of a Silenced Gene in Synthetic Nuclei." Molecular and Cellular Biology 20, no. 11 (2000): 4169–80. http://dx.doi.org/10.1128/mcb.20.11.4169-4180.2000.

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ABSTRACT Aberrant expression of developmentally silenced genes, characteristic of tumor cells and regenerating tissue, is highly correlated with increased cell proliferation. By modeling this process in vitro in synthetic nuclei, we find that DNA replication leads to deregulation of established developmental expression patterns. Chromatin assembly in the presence of adult mouse liver nuclear extract mediates developmental stage-specific silencing of the tumor marker gene alpha-fetoprotein (AFP). Replication of silenced AFP chromatin in synthetic nuclei depletes sequence-specific transcription

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Petkov, Stoyan, Zoltan Ivics, and Heiner Niemann. "PROGRESS TOWARDS THE DERIVATION OF PORCINE INDUCED PLURIPOTENT STEM CELLS." Reproduction, Fertility and Development 24, no. 1 (2012): 284. http://dx.doi.org/10.1071/rdv24n1ab243.

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Porcine induced pluripotent cells (iPSC) are considered an important large animal model for developing personalized stem cell therapies. Since the derivation of the first mouse and human iPSC, there have been relatively few reports regarding the reprogramming of pig somatic cells into pluripotency, exclusively with the use of transcription factors from human and mouse origin. To investigate whether using species-specific transcription factors would allow for an efficient reprogramming of porcine somatic cells, we have developed a Sleeping Beauty (SB) transposon system based on the porcine OCT4

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Penttinen, Pauliina, Jan Jaehrling, Anastasios E. Damdimopoulos, et al. "Diet-Derived Polyphenol Metabolite Enterolactone Is a Tissue-Specific Estrogen Receptor Activator." Endocrinology 148, no. 10 (2007): 4875–86. http://dx.doi.org/10.1210/en.2007-0289.

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Numerous dietary compounds can modify gene expression by binding to the members of the nuclear receptor superfamily of transcription factors. For example, dietary polyphenols, such as soy isoflavones genistein and daidzein, modulate the activity of the estrogen receptors (ERs)-α and ERβ. An additional class of dietary polyphenols that modulate cellular signaling pathways are lignans, compounds that are common constituents of Western diets. In this study, we show that a metabolite of dietary lignans, enterolactone, at physiological concentrations, activates ER-mediated transcription in vitro wi

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Nagar, Saumya, Sarah M. Noveral, Dorit Trudler, et al. "MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress." Proceedings of the National Academy of Sciences 114, no. 20 (2017): E4048—E4056. http://dx.doi.org/10.1073/pnas.1613067114.

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Gaining mechanistic insight into interaction between causative factors of complex multifactorial diseases involving photoreceptor damage might aid in devising effective therapies. Oxidative stress is one of the potential unifying mechanisms for interplay between genetic and environmental factors that contribute to photoreceptor pathology. Interestingly, the transcription factor myocyte enhancer factor 2d (MEF2D) is known to be important in photoreceptor survival, as knockout of this transcription factor results in loss of photoreceptors in mice. Here, using a mild light-induced retinal degener

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Park, Yu-Seong, Hyun-Woo Kim, Jin-Hyeon Hwang, et al. "Plum-Derived Exosome-like Nanovesicles Induce Differentiation of Osteoblasts and Reduction of Osteoclast Activation." Nutrients 15, no. 9 (2023): 2107. http://dx.doi.org/10.3390/nu15092107.

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Osteoblasts and osteoclasts play crucial roles in bone formation and bone resorption. We found that plum-derived exosome-like nanovesicles (PENVs) suppressed osteoclast activation and modulated osteoblast differentiation. PENVs increased the proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells and osteoblasts from mouse bone marrow cultures. Notably, PENVs elevated the expression of osteoblastic transcription factors and osteoblast differentiation marker proteins in MC3T3-E1 cells. Higher levels of phosphorylated BMP-2, p38, JNK, and smad1 proteins were detected in

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Liu, Ming, Shuangyun Zhao, Qingjie Lin, and Xiu-Ping Wang. "YAP Regulates the Expression ofHoxa1andHoxc13in Mouse and Human Oral and Skin Epithelial Tissues." Molecular and Cellular Biology 35, no. 8 (2015): 1449–61. http://dx.doi.org/10.1128/mcb.00765-14.

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Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal roles in stem cell proliferation, organ size control, and tumor development. The downstream targets of YAP have been shown to be highly context dependent. In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream targets of YAP in ectoderm-derived tissues.Yapdeficiency in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation. We compared the gene expression profiles of embryonic day 14.5 (E14.5)Yapconditional knockout andY

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Kawaida, Reimi, Toshiaki Ohtsuka, Junichi Okutsu, et al. "Jun Dimerization Protein 2 (JDP2), a Member of the AP-1 Family of Transcription Factor, Mediates Osteoclast Differentiation Induced by RANKL." Journal of Experimental Medicine 197, no. 8 (2003): 1029–35. http://dx.doi.org/10.1084/jem.20021321.

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Osteoclasts are multinucleated cells that resorb bones, and are derived from hematopoietic cells of the monocyte/macrophage lineage. The receptor activator of NF-κB ligand (RANKL, also called ODF/TRANCE/OPGL) stimulates both osteoclast differentiation from osteoclast progenitors and activation of mature osteoclasts. To identify genes responsible for osteoclast differentiation, we used a molecular indexing technique. Here, we report a clone of one of these genes whose transcription is induced by soluble RANKL (sRANKL) in both the RAW264.7 cells of the mouse macrophage cell line and the mouse pr

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Kukita, Akiko, Toshio Kukita, Mamoru Ouchida, Hidefumi Maeda, Hitomi Yatsuki, and Osamu Kohashi. "Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis." Blood 94, no. 6 (1999): 1987–97. http://dx.doi.org/10.1182/blood.v94.6.1987.

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Abstract The differentiation of osteoclasts is regulated by transcription factors expressed in cells of osteoclast lineage. We isolated here a potential transcription factor from a cDNA library of an enriched population of preosteoclasts and osteoclasts. The cDNA encodes a protein with N-terminal POZ domain and C-terminalKrüppel-like zinc fingers. We designate this protein as osteoclast-derived zinc finger (OCZF). OCZF was found to be rat homologue of mouse leukemia/lymphoma-related factor (LRF). Northern blot and in situ hybridization analysis showed OCZF mRNA at a high level in osteoclasts

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Kukita, Akiko, Toshio Kukita, Mamoru Ouchida, Hidefumi Maeda, Hitomi Yatsuki, and Osamu Kohashi. "Osteoclast-Derived Zinc Finger (OCZF) Protein With POZ Domain, a Possible Transcriptional Repressor, Is Involved in Osteoclastogenesis." Blood 94, no. 6 (1999): 1987–97. http://dx.doi.org/10.1182/blood.v94.6.1987.418k26_1987_1997.

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The differentiation of osteoclasts is regulated by transcription factors expressed in cells of osteoclast lineage. We isolated here a potential transcription factor from a cDNA library of an enriched population of preosteoclasts and osteoclasts. The cDNA encodes a protein with N-terminal POZ domain and C-terminalKrüppel-like zinc fingers. We designate this protein as osteoclast-derived zinc finger (OCZF). OCZF was found to be rat homologue of mouse leukemia/lymphoma-related factor (LRF). Northern blot and in situ hybridization analysis showed OCZF mRNA at a high level in osteoclasts and kidne

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Seewald, Michael J., Peter Ellinghaus, Astrid Kassner, et al. "Genomic profiling of developing cardiomyocytes from recombinant murine embryonic stem cells reveals regulation of transcription factor clusters." Physiological Genomics 38, no. 1 (2009): 7–15. http://dx.doi.org/10.1152/physiolgenomics.90287.2008.

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Cardiomyocytes derived from pluripotent embryonic stem cells (ESC) have the advantage of providing a source for standardized cell cultures. However, little is known on the regulation of the genome during differentiation of ESC to cardiomyocytes. Here, we characterize the transcriptome of the mouse ESC line CM7/1 during differentiation into beating cardiomyocytes and compare the gene expression profiles with those from primary adult murine cardiomyocytes and left ventricular myocardium. We observe that the cardiac gene expression pattern of fully differentiated CM7/1-ESC is highly similar to ad

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Maronde, Erik. "Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line." International Journal of Molecular Sciences 21, no. 22 (2020): 8658. http://dx.doi.org/10.3390/ijms21228658.

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Signaling pathways, depending on the second messenger molecule cAMP, modulate hippocampal cell signaling via influencing transcription factors like cAMP-regulated element-binding protein (CREB) or early growth response 1 EGR1/Krox24/zif268/ZENK (EGR1). Here, we investigated two reporter cell lines derived from an immortalized hippocampal neuronal cell line stably expressing a CRE- or EGR1-luciferase reporter gene (HT22CREluc and HT22EGR1luc, respectively). The cells were subjected to phosphodiesterase inhibitors and other cAMP-modulating agents to investigate dose- and time-dependent phosphodi

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Tsakiridis, Anestis, and Valerie Wilson. "Assessing the bipotency of in vitro-derived neuromesodermal progenitors." F1000Research 4 (April 28, 2015): 100. http://dx.doi.org/10.12688/f1000research.6345.1.

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Retrospective clonal analysis in the mouse has demonstrated that the posterior spinal cord neurectoderm and paraxial mesoderm share a common bipotent progenitor. These neuromesodermal progenitors (NMPs) are the source of new axial structures during embryonic rostrocaudal axis elongation and are marked by the simultaneous co-expression of the transcription factors T(Brachyury) (T(Bra)) and Sox2. NMP-like cells have recently been derived from pluripotent stem cells in vitro following combined stimulation of Wnt and fibroblast growth factor (FGF) signaling. Under these conditions the majority of

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Tsakiridis, Anestis, and Valerie Wilson. "Assessing the bipotency of in vitro-derived neuromesodermal progenitors." F1000Research 4 (July 31, 2015): 100. http://dx.doi.org/10.12688/f1000research.6345.2.

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Retrospective clonal analysis in the mouse has demonstrated that the posterior spinal cord neurectoderm and paraxial mesoderm share a common bipotent progenitor. These neuromesodermal progenitors (NMPs) are the source of new axial structures during embryonic rostrocaudal axis elongation and are marked by the simultaneous co-expression of the transcription factors T(Brachyury) (T(Bra)) and Sox2. NMP-like cells have recently been derived from pluripotent stem cells in vitro following combined stimulation of Wnt and fibroblast growth factor (FGF) signaling. Under these conditions the majority of

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Kirak, Oktay, Eugene Ke, Kevin Y. Yang, et al. "Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts." International Journal of Molecular Sciences 21, no. 16 (2020): 5743. http://dx.doi.org/10.3390/ijms21165743.

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Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear. Here, we derived embryonic stem (ES) cell lines from diabetes-prone non-obese diabetic (NOD) and healthy C57BL/6 (B6) mice. While overall pluripotency markers were indistinguishable between newly derived NOD and B6 ES cells, we discovered several differentially expressed genes that normally are not

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