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Relevant bibliographies by topics / Mouse early embryo development / Dissertations / Theses

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Dissertations / Theses on the topic 'Mouse early embryo development'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Chisholm, J. C. "Cell diversification in the mouse early embryo." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384438.

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2

Sharif, Bedra Usam Ismail. "M-Phase kinases in mouse oocyte maturation and early embryo development." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609472.

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3

Kyprianou, Christos. "Morphogenesis of the early post-implantation mouse embryo." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290301.

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The morphogenetic events that give rise to the early post-implantation mouse embryo (egg cylinder) have not been thoroughly studied and our knowledge is restricted to "snap-shot" descriptions of embryos recovered at different stages of implantation from the mother. A central feature of the egg cylinder is the pro-amniotic cavity, which spans the embryo and participates in formation of the extraembryonic membranes. The major aims of my PhD studies have been to reveal how this cavity is formed (Aim 1) and then how the egg cylinder grows (Aim 2). In order to address how the pro-amniotic cavity fo

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4

Alexandrova, Stoyana. "In vivo behaviour of embryonic stem cells in early mouse embryo development." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708686.

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5

Corujo, Simon Elena. "Wnt/β-catenin signalling facilitates cell fate decision making in the early mouse embryo". Thesis, University of Bath, 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761022.

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At embryonic day 3.5 (E3.5), inner cell mass (ICM) cells co-express the transcription factors NANOG and GATA6. Between E3.5 and E4.5, cells of the ICM differentiate into epiblast (Epi) and primitive endoderm (PrE). These two lineages are distinguished by the differential expression of the previously coexpressed transcription factors; Epi cells express NANOG while PrE cells express GATA6. FGF/ERK signalling is responsible for Epi and PrE differentiation but it does not explain the initial co-expression of both factors and how the mutually exclusive expression arises. β-catenin is the downstream

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6

Harrison, Sarah Ellys. "Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275424.

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Successful mammalian development to term requires that embryonic and extra-embryonic tissues communicate and grow in coordination, to form the body. After implanting into the uterus, the mouse embryo is comprised of three cell lineages: first, the embryonic epiblast (EPI) that forms the embryo proper, second, the extra-embryonic ectoderm (ExE) which contributes to the foetal portion of the placenta, and third, the visceral endoderm (VE) that contributes to the yolk sac. These three tissues form a characteristic ‘egg-cylinder’ structure, which allows signals to be exchanged between them and set

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7

Huang, Tingting. "Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/694.

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Early post-implantation vertebrate embryos are shaped by complex cellular and molecular mechanisms. In mice, the visceral endoderm, an extraembryonic cell lineage that appears before gastrulation, provides several important functions such as nutrition and mechanical protection. My thesis research focused on the role of the visceral endoderm in embryo patterning, a newly discovered function for this tissue. My results showed that an interplay between two subpopulations of visceral endoderm the anterior and posterior visceral endoderm, located on the opposite sides of the developing conceptus, a

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8

Huang, Tingting. "Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/694.

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Early post-implantation vertebrate embryos are shaped by complex cellular and molecular mechanisms. In mice, the visceral endoderm, an extraembryonic cell lineage that appears before gastrulation, provides several important functions such as nutrition and mechanical protection. My thesis research focused on the role of the visceral endoderm in embryo patterning, a newly discovered function for this tissue. My results showed that an interplay between two subpopulations of visceral endoderm the anterior and posterior visceral endoderm, located on the opposite sides of the developing conceptus, a

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9

Ganeva, Veronika Veskova. "Acquisition of renogenic competence in the early mouse embryo and embryonic stem cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5907.

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The acquisition of renogenic competence (the ability to give rise to kidney) during embryonic development is not yet fully understood. Clarifying the temporal and molecular aspects of this process is equally essential for understanding excretory system development and for devising methods for successful differentiation of embryonic stem cells (ESCs) to renal cells for disease modeling, toxicology screening and potential cell replacement therapies. In embryo development, the metanephric (permanent) kidney arises as a result of inductive interactions between two embryonic structures that arise i

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10

Saiz, Nestor. "Regulation of cell fate and cell behaviour during primitive endoderm formation in the early mouse embryo." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/regulation-of-cell-fate-and-cell-behaviour-during-primitive-endoderm-formation-in-the-early-mouse-embryo(d40bb786-85ed-4efd-af64-aab331df98e8).html.

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The preimplantation stages of mammalian development are dedicated to the differentiation of two extraembryonic epithelia, the trophectoderm (TE) and the primitive endoderm (PrE), and their segregation from the pluripotent embryonic lineage, the epiblast. The TE and PrE are responsible for implantation into the uterus and for producing the tissues that will support and pattern the epiblast as it develops into the foetus. PrE and epiblast are formed in a two step process that involves random cell fate specification, mediated by fibroblast growth factor (FGF) signalling, and cell sorting through

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11

Senft, Anna Dorothea. "Investigating TGFβ signals in cell fate specification in the early mouse embryo". Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:d9365934-8a34-4f4f-8a38-8aa221b94977.

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TGFβ signalling via Smad transcription factors is essential for axis patterning and subsequent cell fate specification during mammalian embryogenesis. However, the cellular and molecular mechanisms have been difficult to characterise in vivo due to early embryonic lethality of mouse mutants and redundant functional activities. Here I show that combined deletion of closely related Smad2 and Smad3 in mouse embryonic stem cells impairs induction of lineage specific gene expression during differentiation, while extra-embryonic gene expression is up-regulated. Preliminary data suggest that the unde

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12

Cortés, Albarracín Paola Andrea 1990. "Investigating the role of transcription factor Nkx1-2 in mouse embryonic stem cell pluripotency, self-renewal and differentiation." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668122.

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Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been shown to be important for controlling the expression of transcription factors that orchestrate the characteristic ESC gene expression programme. It remains unclear, however, the exact mechanisms by which the Wnt pathway (via tcf3) contributes to enhance the maintenance of ESCs in a naïve state. Furthermore, little is known of the identity of Wnt-dependent downstream targ

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13

Glaser, Juliane. "Functional characterization of the imprinted Liz/Zdbf2 locus in mice : from the early embryo to adult physiology." Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS243.

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L’empreinte parentale est un mécanisme de régulation épigénétique qui réduit l’expression d’environ 120 gènes à une seule dose parentale. L’expression monoallélique dépend de marques différentielles de méthylation de l’ADN, établies dans l’ovocyte et le spermatozoïde et maintenues après fécondation dans l’individu en développement. Chez les mammifères, les gènes soumis à empreinte sont essentiels au développement embryonnaire et à certaines fonctions comportementales et physiologiques après la naissance. Définir les mécanismes de régulation et la fonction des gènes soumis à empreinte est une q

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14

Gurchenkov, Vasily. "The functional study of the asymmetric specific element of the Nodal gene during the early mouse development." Paris 6, 2009. http://www.theses.fr/2009PA066056.

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Le travail décrit dans ce manuscrit est une étude du fonctionnement de la voie de signalisation du facteur de type TGF-beta Nodal pendant l’embryogenèse précoce de la souris. Ce travail est centré sur l’analyse de l’activité de l’ASE, une séquence régulatrice du gène Nodal. Cette séquence est une cible de la voie de signalisation Smad2,3, qui transduit le signal Nodal, et permet donc au gène Nodal d’amplifier sa propre expression. Des lignées transgéniques où l’expression de protéines fluorescentes est placée sous le contrôle de l’ASE avaient été générées au laboratoire. La caractérisation de

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15

Abelló, Sumpsi Gina. "The early development of the inner ear: the role of notch and fgf pathways in aerly otic neural versus non-neural patterning." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7121.

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Otic neuronal precursors are specified in the otic placode but interestingly do so only in the anterior domain of the otic placode, the proneural domain. In the present study, we have explored why only this territory has the competence to undergo neurogenesis, this means the early events of otic proneural regionalization and neural commitment. The proneural and non-neural domains presented complementary gene expression patterns of transcription factors and members of the Notch pathway. Overall, we propose that proneural character is acquired in the anterior territory by the action of localized

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16

Houghton, Franchesca Dawn. "Energy metabolism of the early mouse embryo." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337151.

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17

Houliston, Evelyn. "Microtubule organisation in the early mouse embryo." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254432.

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18

Lamb, Victoria Kay. "Determinants of growth in the early mouse embryo." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336574.

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19

Murray, Patricia Ann. "Early mouse development." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366681.

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The five manuscripts presented here concern events that occur during the early stages of mouse development, beginning with differentiation of primitive endoderm and ending with formation of the proamniotic cavity. The main focus of the work has been the role of the basement membrane in early development, with particular reference to its role in the regulation of epiblast and extraembryonic endodermal cell differentiation, parietal endodermal cell migration and programmed cell death (manuscripts 1, 3 and 4). HOW"9ver,the critical role played by the basement membrane in these processes prompted

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20

Bloom, Theodora Leah. "Protein phosphorylation and cell diversification in the mouse early embryo." Thesis, University of Cambridge, 1990. https://www.repository.cam.ac.uk/handle/1810/250962.

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This dissertation reports the results of studies into the control of compaction of the mouse preimplantation embryo. Compaction is a post-translationally controlled rearrangement of cell contacts and the cytoskeleton that occurs at the 8-cell stage of development. This re-arrangement seems to be necessary for the differentiation of the two cell types present in the blastocyst. Protein phosphorylation is a post-translational modification believed to be important in the modulation of cell shape and cytoskeletal assembly. It is therefore feasible to propose a role for protein phosphorylation in c

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21

McKeegan, Paul J. "Metabolic regulation during early embryo development." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/8954/.

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The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consumption rate (OCR), representing overall oxidative metabolism, has been reported in several species but few studies have examined the bioenergetics of embryo development. Several methods were optimised to measure components of OCR by individual embryos. On average, 66% of blastocyst OCR was coupled to ATP synthesis, the majority being complex I-depe

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22

Stokes, Paula Jane. "Evaluation of porcine early embryo development." Thesis, University of York, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428418.

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23

McKeegan, Paul Joseph. "Metabolic regulation during early embryo development." Thesis, University of Hull, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646839.

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The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consumption rate (OCR), representing overall oxidative metabolism, has been reported in several species but few studies have examined the bioenergetics of embryo development. Several methods were optimised to measure components of OCR by individual embryos. On average, 66% of blastocyst OCR was coupled to ATP synthesis, the majority being complex I-depe

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24

Legge, M. "Determinants in preimplantation mouse development." Thesis, University of Essex, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235442.

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25

Green, Mark Philip. "Progesterone and early embryo development in cattle." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272358.

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26

Graham, Sarah Jane Lehar. "Novel molecular mechanisms in pre-implantation mouse embryo development." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708487.

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27

Jędrusik, Agnieszka Józefa. "Dissecting origins and consequences of cell heterogeneity in the early mouse embryo." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609543.

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28

Xie, Sancai. "Oocyte maturation and early embryo development in swine /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487676261011605.

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29

Shum, Alisa Sau Wun. "The development of neural tube defects in the mouse embryo." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306186.

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30

李燕柳 and Yin-lau Lee. "Embryotrophic effects of Vero cell on preimplantation mouse embryo development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223023.

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31

Lee, Yin-lau. "Embryotrophic effects of Vero cell on preimplantation mouse embryo development /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2168747X.

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32

Porchet, Nicolas. "Role of signaling pathays in cell-fate specification in the early mouse embryo." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7096.

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Lors du développement précoce de l’embryon de souris, divers évènements de spécification des destins cellulaires induisent la formation du blastocyste pré-implantatoire. Ces évènements sont majoritairement contrôlés par l’action de voies de signalisation activées via la fixation de molécules signal à la membrane de la cellule. L’activité de ces voies de signalisation permet la régulation de la transcription de gènes cible responsable de l’acquisition d’une identité cellulaire et de son arrangement sous forme de tissu. Ici je m’intéresse aux rôles des voies ACTIVINE/NODAL et βCATENIN dans la sp

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33

Shih, Yu-Huan. "The role of Sox3 in early Zebrafish embryo development." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537792.

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34

Winston, Nicola Jane. "Approaches to the study of early human embryo development." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316818.

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35

Torpey, Nicholas. "Intermediate filament proteins in early Xenopu development." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239192.

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36

Fleming, Angeleen Louise. "Development and prevention of neural tube defects in the mouse embryo." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287550.

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37

Stoddart, Neil Richard. "A possible role for embryo-derived factors during mouse preimplantation development?" Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295921.

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38

Lima, Christine A. "Endogenous Localization and Expression Patterns of Aurora Kinases B and C in Mouse Oocytes and Early Embryos." Digital WPI, 2010. https://digitalcommons.wpi.edu/etd-theses/851.

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"The Aurora Kinase proteins are a family of serine/threonine kinases that have been shown to play fundamental roles in controlling M phase progression in somatic cells. Aurora Kinase A protein is known to be vital for proper spindle assembly and therefore, chromosome segregation. Previous reports have shown that Aurora Kinase B is vital for proper completion of karyokinesis and cytokinesis in somatic cells. The role of Aurora Kinase C in somatic cells has been found to be less clear; however it appears to play an important role in spermatogenesis. Little is known about the role of these Aurora

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39

Parrott, Justine Nicola. "Expression and function of Rel/NF-κB transcription factors in the early mouse embryo". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627394.

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40

Hiraoka, Lea Ritsu. "Mutations affecting early development in the mouse." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1059753530.

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41

Labrousse, Claire A. "Investigation of patterning in early mouse development." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487279.

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Re-patterning is visible and well understood in some species. However, controversy remains as to whether there is pre-patterning in the mouse and if so when and how it is established. In this thesis I looked in detail at the first c1~avage division. FirstIy, the role of the sperm was studied. Marking the position of the anterior end of ft~e sperm tail with oil drops in the zona pellllcida provided evidence against a relation i~tween the sperm and the first cleavage. Embedding the zygotes in alginate with a .fertilisation cone present concurred with the oil marking result in rejecting a role fo

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42

Sedano, Rodolfo Canseco. "Effect of immunoglobulins on early bovine embryo development in vitro." Thesis, Virginia Tech, 1985. http://hdl.handle.net/10919/41575.

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Bovine morulae (day 6: n=257) were obtained to evaluate the [effect of immunoglobulins (Ig) on early bovine embryo development in vitro. Fifty-four cows superovulations were conducted in 36 cows with follicle stimulating hormone. Embryos were collected by non-surgical procedures and morphologically evaluated and randomly assigned to culture. Embryos were cultured in Ham's F-10 containing 10% (6.4 mg/ml) steer serum (SS), 1% (.64 mg/ml) bovine gamma . globulins (GG), 1% (.64 mg/ml) bovine IgG, 1% (.64 mg/ml) bovine 1gM, 10% SS plus 1% GG, 10% SS plus 1% 1gG, or 10% SS plus 1% 1gM. Emb

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43

Manning, Elizabeth. "Development of the hypothalamic infundibulum in the early chick embryo." Thesis, University of Sheffield, 2004. http://etheses.whiterose.ac.uk/15096/.

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In the posterior neural tube of vertebrate embryos, the secreted signalling molecules Sonic hedgehog (Shh) and bone morphogenetic proteins (BMPs) are expressed at opposite poles of the neural tube, and act antagonistically to pattern the dorso-ventral axis of the neural tube. In contrast, in the ventral diencephalon, in regions that will give rise to the hypothalamus, BMPs and Shh are initially co-expressed. Subsequently, Shh shows a dynamic pattern of expression, first undergoing a medio-Iateral expansion and then disappearing from ventro-medial cells that will form the infundibulum. In this

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44

Wongtawan, Tuempong. "Epigenetic and chromatin reprogramming in mouse development and embryonic stem cells." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/8048.

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It is well established that epigenetics and chromatin modifications are important factors that can govern gene activity and nuclear architecture. They are also proven to be essential for normal embryonic development and cell differentiation. One important event during mouse development is the establishment of epigenetic reprogramming which is believed to be essential for normal growth and development, however; the mechanism is still poorly understood. The general objective of this PhD study was to investigate the profiles and mechanisms of epigenetic and chromatin modifications during normal m

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45

Kwan, Chun-kit Peter, and 關駿傑. "Development and application of a single mouse embryo DNA methylation-detection assay." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197532.

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During preimplantation embryonic development, imprinting genes are susceptible to methylation changes by artificial manipulation, which may lead to developmental abnormalities. In addition, environmental endocrine disruptors (EDs) in everyday household products are also found to perturb fertility development and cause epigenetic aberrations. While embryo supply is scarce and conventional epigenetic studies require embryos in vast amount, an assay was developed in this study to examine the methylation statuses of imprinting genes using DNA from single mouse blastocysts cultured in-vitro or expo

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46

Panton, Rose. "Maternal diet and programming of embryo and fetal development in the mouse." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/66255/.

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Plasticity is a prominent feature of early development, and is necessary to allow the fetus in utero to adapt to the continual variation in nutrient and oxygen supply it receives from the mother. In contrast to adaptations made in adult life, those made during fetal life tend to become permanent and irreversible (i.e. programmed). This is due to the existence of sensitive periods which are brief windows of growth and development in early life during which there is an increased susceptibility to programming influences (Barker, 1999). Under-nutrition (or other adverse influences) occurring durin

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47

Kelly, Sara M. "Paternal cyclophosphamide exposure exerts deleterious effects on early rat embryo development." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41634.

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Cyclophosphamide is an alkylating agent which has deleterious effects on reproduction in both males and females. When administered to male rats in chronic low doses (6 mg/kg/day), cyclophosphamide caused a dose-dependent increase in post-implantation death of the offspring. On day 7 of gestation, two days after implantation, the inner cell mass-derived embryonic tissues were retarded or absent while trophectoderm-derived extraembryonic tissues appeared normal. The preimplantation growth of embryos sired by cyclophosphamide-treated males was affected; as early as day 3 there was a significant d

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48

Whitear, Sarah-Louise. "The Bovine oviduct and early embryo development : Role of amino acids." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516545.

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49

Batista, Mariana Raposo. "Notch and Wnt signaling interplay on regulation of early embryo development." Doctoral thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2020. http://hdl.handle.net/10400.5/20972.

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Tese de Doutoramento em Ciências Veterinárias, na especialidade de Ciências Biológicas e Biomédicas<br>Mammalian early embryo development requires action of a complex network of cell signaling pathways that coordinates cellular proliferation and differentiation events. Notch is a major regulator in embryonic and adult scenarios, also interplaying with other signaling pathways, such as Wnt. The objective of this work was to determine Notch signaling status in early embryo development and its influence on cellular differentiation and pluripotency maintenance, and on embryo competence to im

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50

SONG, NI. "GENETIC ANALYSIS OF EARLY LENS DEVELOPMENT IN MOUSE." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1195488045.

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