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Journal articles on the topic 'Mouse early embryo development'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Duan, Xing, Kun-Lin Chen, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim, and Shao-Chen Sun. "ROCK inhibition prevents early mouse embryo development." Histochemistry and Cell Biology 142, no. 2 (2014): 227–33. http://dx.doi.org/10.1007/s00418-014-1201-6.

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2

Jefferson, Wendy N., and Carmen J. Williams. "Early mouse embryo asymmetry." Molecular Reproduction and Development 79, no. 7 (2012): 433. http://dx.doi.org/10.1002/mrd.22050.

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3

Pauerova, Tereza, Lenka Radonova, Kristina Kovacovicova, Lucia Novakova, Michal Skultety, and Martin Anger. "Aneuploidy during the onset of mouse embryo development." Reproduction 160, no. 5 (2020): 773–82. http://dx.doi.org/10.1530/rep-20-0086.

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Aneuploidy is the most frequent single cause leading into the termination of early development in human and animal reproduction. Although the mouse is frequently used as a model organism for studying the aneuploidy, we have only incomplete information about the frequency of numerical chromosomal aberrations throughout development, usually limited to a particular stage or assumed from the occurrence of micronuclei. In our study, we systematically scored aneuploidy in in vivo mouse embryos, from zygotes up to 16-cell stage, using kinetochore counting assay. We show here that the frequency of ane

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4

Ibánez, Elena, Francesca Vidal, and Juan Hidalgo. "Early mouse preimplantation development is unaffected by microinjection of metallothionein antibodies." Zygote 3, no. 1 (1995): 81–84. http://dx.doi.org/10.1017/s0967199400002410.

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SummaryPolyclonal antibodies that cross-react with rodent metallothionein I (MT I) and metallothionein II (MT II) were microinjected in 1-cell and 2-cell mouse embryos, into either the cytoplasm or the nucleus. Regardless of the experimental treatment, mouse embryo development in vitro was not affected and most of the embryos cleaved normally until the morula stage. The results suggest that metallothionein is not essential for normal mouse early preimplantational development, in agreement with recent studies in mice with inactivated MT I and MT II genes.

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5

Han, Zhiming, Rita Vassena, Maggie M. Y. Chi, et al. "Role of glucose in cloned mouse embryo development." American Journal of Physiology-Endocrinology and Metabolism 295, no. 4 (2008): E798—E809. http://dx.doi.org/10.1152/ajpendo.00683.2007.

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Cloned mouse embryos display a marked preference for glucose-containing culture medium, with enhanced development to the blastocyst stage in glucose-containing medium attributable mainly to an early beneficial effect during the first cell cycle. This early beneficial effect of glucose is not displayed by parthenogenetic, fertilized, or tetraploid nuclear transfer control embryos, indicating that it is specific to diploid clones. Precocious localization of the glucose transporter SLC2A1 to the cell surface, as well as increased expression of glucose transporters and increased uptake of glucose

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6

Savatier, P., J. Morgenstern, and R. S. Beddington. "Permissiveness to murine leukemia, virus expression during preimplantation and early postimplantation mouse development." Development 109, no. 3 (1990): 655–65. http://dx.doi.org/10.1242/dev.109.3.655.

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Permissiveness to Moloney Murine Leukemia Virus (MoMuLV) expression was examined during preimplantation and early postimplantation development of the mouse embryo. Blastocysts and 8th, 9th and 10th day postimplantation embryos were infected in vitro with a MoMuLV-based retroviral vector expressing the lacZ gene driven off an internal rat beta-actin promoter. Beta-galactosidase-positive cells were identified in all embryonic tissues including inner cell mass, epiblast, mesoderm, endoderm and definitive ectoderm. In contrast, embryos infected with a MoMuLV-based vector expressing the lacZ gene d

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7

Wiebold, Janet L., and Gary B. Anderson. "Lethality of a tritiated amino acid in early mouse embryos." Development 88, no. 1 (1985): 209–17. http://dx.doi.org/10.1242/dev.88.1.209.

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2- to 4-cell and morula- to blastocyst-stage mouse embryos were cultured for 1 h in tritiated leucine at two specific activities and their subsequent development followed in vitro and in vivo (after transfer to recipients), respectively. 2- to 4-cell embryos that incorporated an average of 42 d.p.m. per embryo were impaired in their ability to develop to the morula and blastocyst stage. Recipients receiving morulae and blastocysts that had incorporated an average of 384 d.p.m. per embryo failed to produce young. Reduction of the specific activity improved the viability of embryos both in vitro

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8

Iwamori, Naoki, Kunihiko Naito, Koji Sugiura, et al. "Phosphorylation of mitogen-activated protein kinase cascade during early embryo development in the mouse." Reproduction, Fertility and Development 12, no. 4 (2000): 209. http://dx.doi.org/10.1071/rd00064.

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The mitogen-activated protein kinase (MAPK) cascade is one of the most important signal transduction pathways that regulate the cell cycle in somatic cells. The present study examined the phosphorylation states of components in the MAPK cascade, Raf-1, MEK-1, and extracellular signal regulated kinases (ERKs), which are activated by mitogens, throughout early mouse embryo development and in cultured somatic cells generally. In somatic cells, Raf-1 and MEK-1 were phosphorylated at M-phase and dephosphorylated during interphase. ERKs were not phosphorylated at any stage during the cell cycle. The

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9

Beebe, LF, and PL Kaye. "Preimplantation development in the streptozotocin-induced diabetic mouse." Reproduction, Fertility and Development 2, no. 4 (1990): 407. http://dx.doi.org/10.1071/rd9900407.

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Streptozotocin (STZ) was used to develop a diabetic mouse model in which to study the development of the preimplantation embryo. STZ doses of 0, 160, 190, 210 and 240 mg kg-1 were given; 190 mg kg-1 was found to be the most suitable as the standard diabetogenic dose, providing about 60% mice with plasma glucose greater than 20 mM. The STZ-diabetic mice responded to superovulation with 10 i.u. of gonadotrophin in the same manner as control mice, producing similar embryo numbers at 48 h, 72 h and 96 h post-hCG. Furthermore, the proportion of 2-cell embryos collected from STZ-diabetic mice which

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10

Haouzi, D., I. Boumela, K. Chebli, and S. Hamamah. "Global, Survival, and Apoptotic Transcriptome during Mouse and Human Early Embryonic Development." BioMed Research International 2018 (November 1, 2018): 1–16. http://dx.doi.org/10.1155/2018/5895628.

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Survival and cell death signals are crucial for mammalian embryo preimplantation development. However, the knowledge on the molecular mechanisms underlying their regulation is still limited. Mouse studies are widely used to understand preimplantation embryo development, but extrapolation of these results to humans is questionable. Therefore, we wanted to analyse the global expression profiles during early mouse and human development with a special focus on genes involved in the regulation of the apoptotic and survival pathways. We used DNA microarray technology to analyse the global gene expre

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11

Kaufman, M. H., and S. Webb. "Postimplantation development of tetraploid mouse embryos produced by electrofusion." Development 110, no. 4 (1990): 1121–32. http://dx.doi.org/10.1242/dev.110.4.1121.

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Despite the fact that a variety of experimental techniques have been devised over the years to induce tetraploid mammalian embryonic development, success rates to date have been limited. Apart from the early study by Snow, who obtained development to term of a limited number of cytochalasin B-induced tetraploid mouse embryos, no other researchers have achieved development of tetraploid embryos beyond the early postimplantation period. We now report advanced postimplantation development of tetraploid mouse embryos following electrofusion of blastomeres at the 2-cell stage, and subsequent transf

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12

Huang, Xian-Ju, Xuguang Wang, Xueshan Ma, et al. "EZH2 is essential for development of mouse preimplantation embryos." Reproduction, Fertility and Development 26, no. 8 (2014): 1166. http://dx.doi.org/10.1071/rd13169.

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Enhancer of zeste homologue 2 (Ezh2) is essential for the development of the early mouse preimplantation embryo. Loss of Ezh2 results in embryonic lethality in mice. Ezh2-deficient embryos display impaired outgrowth potential, defective establishment of Ezh2-null embryonic stem (ES) cells and adherence and differentiation of the trophoblast layer into giant cells. We investigated if Ezh2 controls the fate of embryos at an earlier stage by treating with cycloheximide (CHX) or microinjecting short interfering RNA (siRNA) to restrict embryonic Ezh2 expression during preimplantation. CHX inhibited

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13

Sakkas, D., AO Trounson, and I. Kola. "In vivo cleavage rates and viability obtained for early cleavage mouse embryos in co-culture with oviduct cells." Reproduction, Fertility and Development 1, no. 2 (1989): 127. http://dx.doi.org/10.1071/rd9890127.

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The cleavage rate and development of two-cell mouse embryos to the morulae stage in co-culture with mouse oviduct cells was studied in vitro and compared with those achieved in vivo. Embryos were cultured in Whittingham's T6 (T6), T6 supplemented with fetal calf serum (FCS) and in co-culture with either Dulbecco's Modified Eagles Medium supplemented with sodium lactate (DMEM + 1a) or a modification of T6 medium containing vitamins and amino acids (T6 + v + aa). Co-culture of oviductal cells with DMEM + la medium supported two-cell mouse embryo development to eight cells at a rate significantly

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14

Hiruma, Tamiko, Yuji Nakajima, and Hiroaki Nakamura. "Development of pharyngeal arch arteries in early mouse embryo." Journal of Anatomy 201, no. 1 (2002): 15–29. http://dx.doi.org/10.1046/j.1469-7580.2002.00071.x.

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15

Kolahi, Kevin S., Annemarie Donjacour, Xiaowei Liu, et al. "Effect of Substrate Stiffness on Early Mouse Embryo Development." PLoS ONE 7, no. 7 (2012): e41717. http://dx.doi.org/10.1371/journal.pone.0041717.

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16

Ali, J., W. K. Whitten, and J. N. Shelton. "Effect of culture systems on mouse early embryo development." Human Reproduction 8, no. 7 (1993): 1110–14. http://dx.doi.org/10.1093/oxfordjournals.humrep.a138202.

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17

Imai, Hiroyuki, Wataru Fujii, Ken Takeshi Kusakabe, Yasuo Kiso, and Kiyoshi Kano. "Aggregation recovers developmental plasticity in mouse polyploid embryos." Reproduction, Fertility and Development 31, no. 2 (2019): 404. http://dx.doi.org/10.1071/rd18093.

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Tetraploid embryos normally develop into blastocysts and embryonic stem cells can be established from tetraploid blastocysts in mice. Thus, polyploidisation does not seem to be so harmful during preimplantation development. However, the mechanisms by which early mammalian development accepts polyploidisation are poorly understood. In this study, we aimed to elucidate the effect of polyploidisation on early mammalian development and to further comprehend its tolerance using hyperpolyploid embryos produced by repetitive whole genome duplication. We successfully established several types of polyp

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18

Hsu, Yu-Chin. "Heterogenous Macromolecular Contributions to Early Mouse Embryo Development. (in vitro culture/mouse embryos/abnormal development/growth factors/inductors)." Development, Growth and Differentiation 32, no. 2 (1990): 131–37. http://dx.doi.org/10.1111/j.1440-169x.1990.00131.x.

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19

Lallemand, Yvan, and Philippe Brûlet. "Cell lineages in early mouse embryo." Cell Differentiation and Development 27 (August 1989): 214. http://dx.doi.org/10.1016/0922-3371(89)90647-3.

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20

Ying, Ying, Xi Guo, Yiping Zhong, and Canquan Zhou. "An Exploration of the Impact of Anticentromere Antibody on Early-Stage Embryo." Journal of Immunology Research 2017 (2017): 1–4. http://dx.doi.org/10.1155/2017/4809294.

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Background. Previously, we found women with positive anticentromere antibody showed impaired potential of oocyte maturation and embryo cleavage; the possible mechanism behind this phenomenon was still unknown. Objective. Thus, the present study aimed to preliminarily explore whether ACA could penetrate into the living embryos and impair their developmental potential via in vitro coculture with mouse embryos. Methods. Mouse embryos were collected and used for in vitro culture with polyclonal anticentromere protein A (CENP-A) antibody; then, immunofluorescence assay was performed to determine th

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21

Croteau, S., and Y. Menezo. "Methylation in fertilised and parthenogenetic preimplantation mouse embryos." Zygote 2, no. 1 (1994): 47–52. http://dx.doi.org/10.1017/s0967199400001751.

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SummaryDNA methylation is one of the proposed biochemical mechanisms involved in cell differentiation and in genomic imprinting, and DNA methyltransferase (DMT) is a key enzyme in the embryo since mutation of its gene is lethal early in development. In order to verify that non-viability of uniparental embryos was not due to a defect in the regulation of DMT activity, we compared the metabolism of methylation in parthenogenetic embryos (maternal genome) and in fertilised embryos (maternal and paternal genomes). As regards total methylation, estimated by a measure of S-adenosyl methionine (SAM)

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22

Govindasamy, Niraimathi, Binyamin Duethorn, Hatice O. Oezgueldez, Yung S. Kim, and Ivan Bedzhov. "Test-tube embryos - mouse and human development in vitro to blastocyst stage and beyond." International Journal of Developmental Biology 63, no. 3-4-5 (2019): 203–15. http://dx.doi.org/10.1387/ijdb.180379ib.

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Mammalian embryogenesis is intrauterine and depends on support from the maternal environment. Therefore, in order to directly study and manipulate early mouse and human embryos, fine-tuned culture conditions have to be provided to maintain embryo growth in vitro. Over time, the establishment and implementation of embryo culture methods have come a long way, initially enabling the development of few pre-implantation stages, expanding later to support in vitro embryogenesis from fertilization until blastocyst and even ex utero development beyond the implantation stages. Designing culture conditi

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23

Dai, Xiangpeng, Jie Hao, and Qi Zhou. "A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos." REPRODUCTION 138, no. 2 (2009): 301–8. http://dx.doi.org/10.1530/rep-09-0069.

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Many strategies have been established to improve the efficiency of somatic cell nuclear transfer (SCNT), but relatively few focused on improving culture conditions. The effect of different culture media on preimplantation development of mouse nuclear transfer embryos was investigated. A modified sequential media method, named D media (M16/KSOM and CZB-EG/KSOM), was successfully established that significantly improves SCNT embryo development. Our result demonstrated that while lacking any adverse effect on in vivo fertilized embryos, the D media dramatically improves the blastocyst development

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24

Wang, Qiao-Chu, Jun Liu, Fei Wang, et al. "Role of Nucleation-Promoting Factors in Mouse Early Embryo Development." Microscopy and Microanalysis 19, no. 3 (2013): 559–64. http://dx.doi.org/10.1017/s1431927613000032.

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AbstractDuring mitosis nucleation-promoting factors (NPFs) bind to the Arp2/3 complex and activate actin assembly. JMY and WAVE2 are two critical members of the NPFs. Previous studies have demonstrated that NPFs promote multiple processes such as cell migration and cytokinesis. However, the role of NPFs in development of mammalian embryos is still unknown. Results of the present study show that the NPFs JMY and WAVE2 are critical for cytokinesis during development of mouse embryos. Both JMY and WAVE2 are expressed in mouse embryos. After injection of JMY or WAVE2 siRNA, all embryos failed to d

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25

Juneja, Subhash C., and Melvin G. Dodson. "Effect of RU486 on different stages of mouse preimplantation embryos in vitro." Canadian Journal of Physiology and Pharmacology 68, no. 11 (1990): 1457–60. http://dx.doi.org/10.1139/y90-220.

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17β-Hydroxy-11β-(4-dimethylaminophenyl)-17α-(1-propynyl)estra-4,9-dien-3-one (RU486) inhibited the in vitro development of different stages of mouse preimplantation embryos under study. Two-celled embryos, morulae, and early blastocysts were obtained from B6D2F1 mice. The embryos were grown in Ham F-10 nutrient mixture (with glutamine) supplemented with sodium bicarbonate (2.1 g/L), calcium lactate (282 mg/L), and bovine serum albumin (fraction V, 3 mg/mL) at 37 °C in a humidified incubator supplied with 5% CO2 in air. RU486 was added to the culture medium at concentrations of 1, 5, 10, and 20

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26

Saiz, Néstor, and Berenika Plusa. "Early cell fate decisions in the mouse embryo." REPRODUCTION 145, no. 3 (2013): R65—R80. http://dx.doi.org/10.1530/rep-12-0381.

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During mammalian preimplantation development, the fertilised egg gives rise to a group of pluripotent embryonic cells, the epiblast, and to the extraembryonic lineages that support the development of the foetus during subsequent phases of development. This preimplantation period not only accommodates the first cell fate decisions in a mammal's life but also the transition from a totipotent cell, the zygote, capable of producing any cell type in the animal, to cells with a restricted developmental potential. The cellular and molecular mechanisms governing the balance between developmental poten

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27

Takagi, N., and K. Abe. "Detrimental effects of two active X chromosomes on early mouse development." Development 109, no. 1 (1990): 189–201. http://dx.doi.org/10.1242/dev.109.1.189.

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Matings between female mice carrying Searle's translocation, T(X;16)16H, and normal males give rise to chromosomally unbalanced zygotes with two complete sets of autosomes, one normal X chromosome and one X16 translocation chromosome (XnX16 embryos). Since X chromosome inactivation does not occur in these embryos, probably due to the lack of the inactivation center on X16, XnX16 embryos are functionally disomic for the proximal 63% of the X chromosome and trisomic for the distal segment of chromosome 16. Developmental abnormalities found in XnX16 embryos include: (1) growth retardation detecte

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Zhang, Junqiang, Ying Wang, Xiaoguang Liu, et al. "Expression and Potential Role of microRNA-29b in Mouse Early Embryo Development." Cellular Physiology and Biochemistry 35, no. 3 (2015): 1178–87. http://dx.doi.org/10.1159/000373942.

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Background/Aims: MicroRNA-29b (miR29b) has been previously identified in early mouse embryos through miRNA microarray analysis. Recent research has indicated that miR29b participates in DNA methylation by regulating DNA methyltransferase 3a/3b (Dnmt3a/3b) expression. However, the expression pattern and biological function of miR29b in mouse preimplantation embryonic development remain unknown. Methods: In this study, we examined the expression patterns of miR29b and Dnmt3a/3b in mouse early embryos at different developmental stages. Subsequently, expression and localization of DNMT3A/3B protei

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Peng, Hui, Haijun Liu, Fang Liu, et al. "NLRP2 and FAF1 deficiency blocks early embryogenesis in the mouse." Reproduction 154, no. 3 (2017): 245–51. http://dx.doi.org/10.1530/rep-16-0629.

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Nlrp2 is a maternal effect gene specifically expressed by mouse ovaries; deletion of this gene from zygotes is known to result in early embryonic arrest. In the present study, we identified FAF1 protein as a specific binding partner of the NLRP2 protein in both mouse oocytes and preimplantation embryos. In addition to early embryos, both Faf1 mRNA and protein were detected in multiple tissues. NLRP2 and FAF1 proteins were co-localized to both the cytoplasm and nucleus during the development of oocytes and preimplantation embryos. Co-immunoprecipitation assays were used to confirm the specific

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30

López-Casas, Pedro P., Luis A. López-Fernández, Dora B. Krimer, and Jesús del Mazo. "Ran GTPase expression during early development of the mouse embryo." Mechanisms of Development 113, no. 1 (2002): 103–6. http://dx.doi.org/10.1016/s0925-4773(02)00007-2.

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31

Yu, Bo, Thomas H. Smith, Stephanie L. Battle, Shannon Ferrell, and R. David Hawkins. "Superovulation alters global DNA methylation in early mouse embryo development." Epigenetics 14, no. 8 (2019): 780–90. http://dx.doi.org/10.1080/15592294.2019.1615353.

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32

Huang, J. C., W. S. A. Wun, J. S. Goldsby, K. Egan, G. A. FitzGerald, and K. K. Wu. "Prostacyclin receptor signaling and early embryo development in the mouse." Human Reproduction 22, no. 11 (2007): 2851–56. http://dx.doi.org/10.1093/humrep/dem304.

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33

Henckel, Amandine, Szabolcs Tóth, and Philippe Arnaud. "Early mouse embryo development: could epigenetics influence cell fate determination?" BioEssays 29, no. 6 (2007): 520–24. http://dx.doi.org/10.1002/bies.20591.

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34

Kustova, Maria E., Vasilina A. Sokolova, Oksana V. Kidgotko, Mikhail G. Bass, Faina M. Zakharova, and Vadim B. Vasilyev. "Distribution of introduced human mitochondrial DNA in early stage mouse embryos." Medical academic journal 20, no. 2 (2020): 69–78. http://dx.doi.org/10.17816/maj34657.

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Objective. The aim of study was the analysis of human mitochondrial DNA (mtDNA) distribution among murine blastomeres in the embryos developing after an injection of human mitochondria suspension at the stage of one or two cells is presented. Material and methods. Mice CBA/C57Black from Rappolovo aged three weeks were used. Zygotes were obtained upon hormonal stimulation of animals and mated with males. 310 pL of mitochondrial suspension from HepG2 cells was injected into a zygote or one blastomere of a two-cell embryo. Zygotes or two-cell embryos cultured in M3 medium drops covered with

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35

Nagy, A., A. Paldi, L. Dezso, L. Varga, and A. Magyar. "Prenatal fate of parthenogenetic cells in mouse aggregation chimaeras." Development 101, no. 1 (1987): 67–71. http://dx.doi.org/10.1242/dev.101.1.67.

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Parthenogenetically activated BCF1 and fertilized BALB/c embryos were aggregated to form chimaeras. The fate of the parthenogenetic component was followed in the conceptus during the second half of gestation. The results indicate an early strong selection against parthenogenetic cells in the extra-embryonal part, which is presumably complete by term, and a weaker selective process in the embryo. During early development, parthenogenetic cells have nearly normal developmental potency in the embryo, which allows their balanced contribution in the chimaeras on day 12. Later, this contribution dec

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Hisaki, Tomoka, Ikuma Kawai, Koji Sugiura, Kunihiko Naito, and Kiyoshi Kano. "Regulation of embryonic size in early mouse development in vitro culture system." Zygote 22, no. 3 (2013): 340–47. http://dx.doi.org/10.1017/s0967199412000652.

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SummaryMammals self-regulate their body size throughout development. In the uterus, embryos are properly regulated to be a specific size at birth. Previously, size and cell number in aggregated embryos, which were made from two or more morulae, and half embryos, which were halved at the 2-cell stage, have been analysed in vivo in preimplantation and post-implantation development in mice. Here, we examined whether or not the mouse embryo has the capacity to self-regulate growth using an in vitro culture system. To elucidate embryonic histology, cells were counted in aggregated or half embryos i

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Batista, Mariana R., Patrícia Diniz, Daniel Murta, Ana Torres, Luís Lopes-da-Costa, and Elisabete Silva. "Balanced Notch-Wnt signaling interplay is required for mouse embryo and fetal development." Reproduction 161, no. 4 (2021): 385–98. http://dx.doi.org/10.1530/rep-20-0435.

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This study investigated the role of Notch and Wnt cell signaling interplay in the mouse early embryo, and its effects on fetal development. Developmental kinetics was evaluated in embryos in vitro cultured from the 8-16-cell to the hatched blastocyst stage in the presence of signaling inhibitors of Notch (DAPT) and/or Wnt (DKK1). An embryo subset was evaluated for differential cell count and gene transcription of Notch (receptors Notch1-4, ligands Dll1, Dll4, Jagged1-2, effectors Hes1-2) and Wnt (Wnt3a, Lrp6, Gsk3β, C-myc, Tcf4, β-catenin) components, E-cadherin and pluripotency and differenti

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38

Fleming, T. P., D. R. Garrod, and A. J. Elsmore. "Desmosome biogenesis in the mouse preimplantation embryo." Development 112, no. 2 (1991): 527–39. http://dx.doi.org/10.1242/dev.112.2.527.

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The molecular processes underlying the formation of the first desmosomes in the mouse early embryo have been examined by immunocytochemical and biochemical techniques using antibody probes recognising desmosomal proteins 1 and 2 (dp1 + 2, desmoplakins), dp3 (plakoglobin), desmosomal glycoprotein 1 (dg1, desmoglein) and dg2 + 3 (desmocollins). Immunofluorescence labelling of staged intact embryos and synchronised cell clusters indicates that dp1 + 2, dg1 and dg2 + 3 are first detectable on the lateral membrane contact sites between trophectoderm cells in early cavitating blastocysts, coincident

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Vinijsanun, A., and L. Martin. "Effects of progesterone antagonists RU486 and ZK98734 on embryo transport, development and implantation in laboratory mice." Reproduction, Fertility and Development 2, no. 6 (1990): 713. http://dx.doi.org/10.1071/rd9900713.

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Two progesterone antagonists blocked the actions of progesterone on uterine mitosis and epithelial morphology, but had no oestrogenic, anti-oestrogenic, cytotoxic or gestagenic activities in the mouse uterus. They interrupted early pregnancy and were luteolytic. These actions were reversed by treatment with exogenous progestins, but not dexamethasone. Doses of antagonists which blocked pregnancy and were luteolytic induced premature entry of embryos into the uterus on Day 3 and loss from the tract by Day 4. With the more potent RU486, most embryos remaining in the tract on Day 4 were in the ov

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40

Sutherland, Ann E. "Tissue morphodynamics shaping the early mouse embryo." Seminars in Cell & Developmental Biology 55 (July 2016): 89–98. http://dx.doi.org/10.1016/j.semcdb.2016.01.033.

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41

Hess, A. P., J. Hirchenhain, A. Schanz, et al. "Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation." Reproduction, Fertility and Development 18, no. 5 (2006): 509. http://dx.doi.org/10.1071/rd05110.

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After attachment and migration through the endometrial epithelium, the embryo must induce angiogenesis within the endometrial stroma to successfully complete the implantation process. Growth factors have been shown to play an important role in embryo implantation and placentation. The aim of the study was to investigate the expression of angiopoietin-1 and -2 (Ang-1 and -2) mRNA and protein expression during the development of single preimplantation mouse embryos and of possible complementary expression in mouse uteri. Angiopoietin-1 mRNA was expressed throughout development in 78% of zygotes,

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42

Plachta, N. "209 Imaging the Molecular and Cell Dynamics that Form the Early Mouse Embryo." Reproduction, Fertility and Development 30, no. 1 (2018): 245. http://dx.doi.org/10.1071/rdv30n1ab209.

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Our goal is to reveal how mammalian cells resolve their fate, shape, and position in the body in real time. Understanding how these decisions are made is critical to realise how embryos form and what problems compromise human fertility. Yet, their real-time control in vivo remains unknown. Because fixed specimens cannot capture cell dynamics, we established imaging technologies to study cells directly in live mouse embryos. We recently showed how transcription factors search and bind to the DNA to determine the first cell fates of the embryo. We found that differences in the binding of the tra

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Niswander, L., D. Yee, E. M. Rinchik, L. B. Russell, and T. Magnuson. "The albino deletion complex and early postimplantation survival in the mouse." Development 102, no. 1 (1988): 45–53. http://dx.doi.org/10.1242/dev.102.1.45.

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The albino deletion complex in the mouse represents 37 overlapping chromosomal deficiencies that have been arranged into at least twelve complementation groups. Many of the deletions cover regions of chromosome 7 that contain genes necessary for early embryonic development. The work reported here concentrates on two of these deletions (c6H, c11DSD), both of which were known to be lethal around the time of gastrulation when homozygous. A detailed embryological analysis has revealed distinct differences in the lethal phenotype associated with the c6H and c11DSD deletions. c6H homozygous embryos

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Lee, Kai-Fai, Jia-Sen Xu, Yin-Lau Lee, and William S. B. Yeung. "Demilune Cell and Parotid Protein from Murine Oviductal Epithelium Stimulates Preimplantation Embryo Development." Endocrinology 147, no. 1 (2006): 79–87. http://dx.doi.org/10.1210/en.2005-0596.

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In mammals, fertilization and early preimplantation embryo development occur in the oviduct. We hypothesized that interaction exists between the developing embryos and the maternal genital tract, such that the embryos modulate the physiology and gene expression of the oviduct so that it is conducive to their development. By comparing the gene expression patterns in mouse oviducts containing transferred preimplantation embryos with those of oviducts containing oocytes, we report here the characterization of demilune cell and parotid protein (Dcpp), which was up-regulated in the embryo-containin

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Sun, Shao-Chen, Qing-Ling Wang, Wei-Wei Gao, et al. "Actin nucleator Arp2/3 complex is essential for mouse preimplantation embryo development." Reproduction, Fertility and Development 25, no. 4 (2013): 617. http://dx.doi.org/10.1071/rd12011.

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The Arp2/3 complex is a critical actin nucleator, which promotes actin assembly and is widely involved in a diverse range of actin-related processes such as cell locomotion, phagocytosis and the establishment of cell polarity. Previous studies showed that the Arp2/3 complex regulates spindle migration and asymmetric division during mouse oocyte maturation; however, the role of the Arp2/3 complex in early mouse embryo development is still unknown. The results of the present study show that the Arp2/3 complex is critical for cytokinesis during mouse embryo development. The Arp2/3 complex was con

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Zhu, Yan, Ya-Hong Jiang, Ya-Ping He, et al. "Knockdown of regulator of G-protein signalling 2 (Rgs2) leads to abnormal early mouse embryo development in vitro." Reproduction, Fertility and Development 27, no. 3 (2015): 557. http://dx.doi.org/10.1071/rd13269.

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Regulator of G-protein signalling 2 (Rgs2) is involved in G-protein-mediated signalling by negatively regulating the activity of the G-protein α-subunit. In the present study, the expression patterns of Rgs2 in mouse ovarian tissues and early embryos were determined by semiquantitative reverse transcription–polymerase chain reaction, immunohistochemistry and immunofluorescent analyses. Rgs2 expression was observed in the ovarian tissues of adult female mice, with an almost equal expression levels during different stages of the oestrous cycle. Rgs2 was abundant in the cytoplasm, membrane, nucle

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McCue, K., M. Pantaleon, and P. L. Kaye. "228. Proteasomal activity during mouse preimplantation development." Reproduction, Fertility and Development 20, no. 9 (2008): 28. http://dx.doi.org/10.1071/srb08abs228.

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Function of the 26S proteasome, a proteolytic organelle directed at proteins targeted for turnover by polyubiquitination, in preimplantation embryos is unclear. But it is well known to play a role in regulating meiosis. This paper reports the distribution of the proteasome and assessment of its functional importance in preimplantation development. Embryos from superovulated mice were either paraformaldehyde fixed for immunolabelling with a rabbit polyclonal antibody against the 20S proteasome core or cultured in KSOM medium with and without reversible (MG132) or irreversible (β-lactone) protea

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West, J. D., and J. H. Flockhart. "Genetic differences in glucose phosphate isomerase activity among mouse embryos." Development 107, no. 3 (1989): 465–72. http://dx.doi.org/10.1242/dev.107.3.465.

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We have compared mouse embryos of three heterozygous, congenic genotypes (with high, medium and low levels of oocyte-coded glucose phosphate isomerase (GPI-1) activity respectively) to test whether 1) the survival time of oocyte-coded GPI-1 activity in the early embryo is affected by its activity level in the oocyte and 2) whether embryo-coded GPI-1 is detected earlier in embryos that inherit low levels of oocyte-coded GPI-1. The oocyte-coded GPI-1 was entirely GPI-1A allozyme in the high and medium groups but was the less stable GPI-1C allozyme in the low group. We determined total GPI-1 acti

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Kovarikova, Veronika, Jan Burkus, Pavol Rehak, Adela Brzakova, Petr Solc, and Vladimir Baran. "Aurora kinase A is essential for correct chromosome segregation in mouse zygote." Zygote 24, no. 3 (2015): 326–37. http://dx.doi.org/10.1017/s0967199415000222.

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SummaryAurora-A kinase (AURKA), a member of the serine/threonine protein kinase family, is involved in multiple steps of mitotic progression. It regulates centrosome maturation, mitotic spindle formation, and cytokinesis. While studied extensively in somatic cells, little information is known about AURKA in the early cleavage mouse embryo with respect to acentrosomal spindle assembly. In vitro experiments in which AURKA was inactivated with specific inhibitor MLN8237 during the early stages of embryogenesis documented gradual arrest in the cleavage ability of the mouse embryo. In the AURKA-inh

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Bedzhov, Ivan, Sarah J. L. Graham, Chuen Yan Leung, and Magdalena Zernicka-Goetz. "Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo." Philosophical Transactions of the Royal Society B: Biological Sciences 369, no. 1657 (2014): 20130538. http://dx.doi.org/10.1098/rstb.2013.0538.

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A critical point in mammalian development is when the early embryo implants into its mother's uterus. This event has historically been difficult to study due to the fact that it occurs within the maternal tissue and therefore is hidden from view. In this review, we discuss how the mouse embryo is prepared for implantation and the molecular mechanisms involved in directing and coordinating this crucial event. Prior to implantation, the cells of the embryo are specified as precursors of future embryonic and extra-embryonic lineages. These preimplantation cell fate decisions rely on a combination

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