Relevant bibliographies by topics / Mouse fibroblast cell lines

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Mouse fibroblast cell lines'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Mouse fibroblast cell lines"

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Onoue, H., Y. Ebi, H. Nakayama, XM Ru, Y. Kitamura, and J. Fujita. "Suppressive effect of Sl/Sld mouse embryo-derived fibroblast cell lines on diffusible factor-dependent proliferation of mast cells." Blood 74, no. 5 (1989): 1557–62. http://dx.doi.org/10.1182/blood.v74.5.1557.1557.

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Abstract Two modes of mast cell growth are present, one dependent on diffusible growth factors (interleukins [IL] 3 and 4) and another dependent on contact with fibroblasts. The 3T3 fibroblast cell lines derived from WCB6F1-+/+ mouse embryos supported the proliferation of cultured mast cells (CMC), whereas the 3T3 fibroblast cell lines from WCB6F1-Sl/Sld mouse embryos did not. To investigate the relationship between growth factor-dependent and fibroblast-dependent growths of mast cells, we cocultured CMC and 3T3 fibroblasts in the presence of diffusible growth factors. WCB6F1-+/+ mouse embryo-
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Onoue, H., Y. Ebi, H. Nakayama, XM Ru, Y. Kitamura, and J. Fujita. "Suppressive effect of Sl/Sld mouse embryo-derived fibroblast cell lines on diffusible factor-dependent proliferation of mast cells." Blood 74, no. 5 (1989): 1557–62. http://dx.doi.org/10.1182/blood.v74.5.1557.bloodjournal7451557.

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Two modes of mast cell growth are present, one dependent on diffusible growth factors (interleukins [IL] 3 and 4) and another dependent on contact with fibroblasts. The 3T3 fibroblast cell lines derived from WCB6F1-+/+ mouse embryos supported the proliferation of cultured mast cells (CMC), whereas the 3T3 fibroblast cell lines from WCB6F1-Sl/Sld mouse embryos did not. To investigate the relationship between growth factor-dependent and fibroblast-dependent growths of mast cells, we cocultured CMC and 3T3 fibroblasts in the presence of diffusible growth factors. WCB6F1-+/+ mouse embryo-derived 3
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Plaisancié, Pascale, Charline Buisson, Edwin Fouché, et al. "Study of the colonic epithelial-mesenchymal dialogue through establishment of two activated or not mesenchymal cell lines: Activated and resting ones differentially modulate colonocytes in co-culture." PLOS ONE 17, no. 8 (2022): e0273858. http://dx.doi.org/10.1371/journal.pone.0273858.

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Continuous and rapid renewal of the colonic epithelium is crucial to resist the plethora of luminal deleterious agents. Subepithelial fibroblasts contribute to this turnover by regulating epithelial proliferation and differentiation. However, when intestinal homeostasis is disturbed, fibroblasts can acquire an activated phenotype and play a major role in the progression of intestinal pathologies. To evaluate the involvement of fibroblasts in the regulation of colonocytes under homeostatic or pathological conditions, we established resting and activated conditionally immortalized fibroblast cel
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Ahmed, Manhal F. "Cytotoxic effect of green tea leaf extract on tumor cell line." Iraqi Journal of Veterinary Medicine 41, no. 1 (2017): 71–75. http://dx.doi.org/10.30539/iraqijvm.v41i1.83.

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The study was conducted to evaluate antitumor effects of green tea (Camellia sinensis) extracts (aqueous and methanolic) on Rhabdomyosarcoma; cell line and a normal cell line; mouse embryo fibroblast; Chemical detections of green tea extracts revealed that the aqueous and methanolic extracts were positive for flavonoids, alkaloids, phenol and glycosides. The percentage growth inhibition of five plant concentrations (50, 100, 250, 500 and 1000 µg/ml) were assessed in vitro using tumor cell lines Rhabdomyosarcoma and normal cell line mouse embryonic fibroblasts. The results revealed that the fiv
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Baumann, Jörg G., Derya Unutmaz, Michael D. Miller, et al. "Murine T Cells Potently Restrict Human Immunodeficiency Virus Infection." Journal of Virology 78, no. 22 (2004): 12537–47. http://dx.doi.org/10.1128/jvi.78.22.12537-12547.2004.

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ABSTRACT Development of a mouse model for human immunodeficiency virus type 1 (HIV-1) infection has advanced through the progressive identification of host cell factors required for HIV-1 replication. Murine cells lack HIV-1 receptor molecules, do not support efficient viral gene expression, and lack factors necessary for the assembly and release of virions. Many of these blocks have been described using mouse fibroblast cell lines. Here we identify a postentry block to HIV-1 infection in mouse T-cell lines that has not been detected in mouse fibroblasts. While murine fibroblastic lines are co
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Janusz, M. J., and M. Hare. "Cartilage degradation by cocultures of transformed macrophage and fibroblast cell lines. A model of metalloproteinase-mediated connective tissue degradation." Journal of Immunology 150, no. 5 (1993): 1922–31. http://dx.doi.org/10.4049/jimmunol.150.5.1922.

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Abstract A number of human and mouse macrophage and fibroblast cell lines were examined for their ability to degrade cartilage proteoglycan in an attempt to establish a cell culture model of cartilage degradation. The mouse transformed macrophage cell line J774A.1 alone or in combination with the mouse transformed fibroblast cell line 10ME HD A.5R.1 were the only cell lines capable of extensively degradating cartilage proteoglycan. Incubation of the macrophage cell line J774A.1 on heat-killed cartilage disks resulted in the release of 36% +/- 8 (mean +/- SEM, n = 5) of the radiolabeled cartila
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Rahimi, Amir Mohammad, Mingfang Cai, and Sigrid Hoyer-Fender. "Heterogeneity of the NIH3T3 Fibroblast Cell Line." Cells 11, no. 17 (2022): 2677. http://dx.doi.org/10.3390/cells11172677.

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The embryonic mouse fibroblast cell line NIH3T3 is widely used in life science research, including the study of cell cycle control and primary cilia. Fibroblasts are the most important cell type in connective tissue, as they produce components of the extracellular matrix and determine tissue architecture. However, they are very heterogeneous and consist of subtypes specific to their organ of residence, among others. The NIH3T3 cell line was derived from whole mouse embryos that developed to pre-birth and is therefore most likely composed of different fibroblast subtypes. Furthermore, prolonged
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Höhne, Kerstin, Annett Wagenknecht, Corinna Maier, et al. "Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6." Cells 13, no. 3 (2024): 238. http://dx.doi.org/10.3390/cells13030238.

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Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown origin, with a median patient survival time of ~3 years after diagnosis without anti-fibrotic therapy. It is characterized by progressive fibrosis indicated by increased collagen deposition and high numbers of fibroblasts in the lung. It has been demonstrated that CCL18 induces collagen and αSMA synthesis in fibroblasts. We aimed to identify the CCL18 receptor responsible for its pro-fibrotic activities. Methods: We used a random phage display library to screen for potential CCL18-binding peptides, demonstrated
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Ma, Yihe, Yumiao Lin, Wenting Huang, and Xusheng Wang. "Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules." International Journal of Molecular Sciences 23, no. 8 (2022): 4213. http://dx.doi.org/10.3390/ijms23084213.

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The reprogramming of somatic fibroblasts into alternative cell linages could provide a promising source of cells for regenerative medicine and cell therapy. However, the direct conversion of fibroblasts into other functional cell types is still challenging. In this study, we show that dermal-papilla-cell-like cells (DPC-LCs) can be generated by treating fibroblasts, including L929 mouse fibroblast cell lines and somatic mouse fibroblasts, with small molecules. Based on alkaline phosphatase activity and other molecular markers, different compounds or their combinations are needed for converting
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Levina, Elina M., Margarita A. Kharitonova, Yuri A. Rovensky, and Jury M. Vasiliev. "Cytoskeletal control of fibroblast length: experiments with linear strips of substrate." Journal of Cell Science 114, no. 23 (2001): 4335–41. http://dx.doi.org/10.1242/jcs.114.23.4335.

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In order to understand the factors determining the length of fibroblasts, three cell lines (mouse embryonic fibroblasts plus human fibroblast lines AGO 1523 and M19) were cultivated on the usual planar substrate (glass) and on specially prepared narrow linear strips of the same substrate, where the cells could spread only linearly. Morphometric measurements showed that the average length of cells of each type on the ‘unidimensional’ strips was no different from that on the usual ‘bidimensional’ substrate. The addition of colcemid significantly decreased cell length on both substrates, whereas
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Dissertations / Theses on the topic "Mouse fibroblast cell lines"

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Lundblad, Dan. "Studies on the antiproliferative action of interferon : effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 1991. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100575.

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Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. IFNs exert multiple effects on cells exemplified by the establishment of an antiviral state, inhibition of cell proliferation and alteration of different immune reactions. In the present thesis the inhibition of cellular growth concentrated on effects in the early cell cycle have been studied. The human glioma cell line 251 MG was found to be blocked in the S phase of the cell cycle upon addition of IFN both to expon
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Cabuy, Erik. "Investigations of telomere maintenance in DNA damage response defective cells and telomerase in brain tumours." Thesis, Brunel University, 2005. http://bura.brunel.ac.uk/handle/2438/5157.

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Telomeres are nucleoprotein complexes located at the end of chromosomes. They have an essential role in protecting chromosome ends. Telomerase or ALT (alternative lengthening of telomeres) mechanisms maintain telomeres by compensating natural telomeric loss. We have set up a flow-FISH method and using mouse lymphoma cell lines we identified unexpectedly the presence of subpopulations of cells with different telomere lengths. Subpopulations of cells with different telomere lengths were also observed in a human ALT and non-ALT cell line. Differences in telomere length between subpopulations of c
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Orfanoudakis, Georges. "Diadenosine tetraphosphate : implication dans l'activite mitotique, la replication et la reparation du dna." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13121.

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Le diadenosine tetraphosphate (ap**(4)a) est le principal produit de la reaction d'aminoacylation catalysee par certaines aminoacyl-trna synthetases. L'ap**(4)a est une molecule "signal" s'accumulant a l'interphase g1/5 du cycle cellulaire des cellules eucarydes declenchant ainsi la synthese du dna precedant la division cellulaire. Quantification du contenu cellulaire en ap**(4)a et en atp apres synchronisation des cellules (hepertome de rat, fibroblaste de souris) en culture par l'aphidicoline agent bloquant les cellules en phase s et par privation de serum qui arrete la croissance en mi-phas
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Morris, Tracy. "Molecular analysis of mutations at the hprt locus in primary human fibroblast lines." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314815.

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Montenegro, Raquel Carvalho. "Response to EGFR inhibitors in fibroblast cell lines and its association with germline polymorphisms." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1259.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Only a small number of cancer patients benefit from therapy with EGFR inhibitors. It is therefore important to understand the mechanism of action of these drugs and to find predictive markers for drug response to guide the selection of patients who can benefits from these drugs. Although somatic mutations and gene amplification have been correlated with the efficacy of EGFR-targeting therapy, cancer cells and/or patients with normal EGFR expression are also sensitive to these drugs. We then aim to further understand the mechanism u
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Ruddy, Suzanne. "Mutation of the thymidine kinase gene in two mouse tumour cell lines." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336001.

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Rode, Christina. "Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:49b91ea8-36a3-4bcd-8842-baa1ee31c7b9.

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Hematopoietic stem cells emerge from a specialized subset of endothelial cells in the midgestation mouse aorta. This subset, the so-called hemogenic endothelium (HE), undergoes a morphological and molecular change to a hematopoietic cell type, as part of the endothelial-to- hematopoietic transition (EHT). Previously, lack of specific markers prevented mechanistic studies of HE, as well as studies into its developmental origin. Runx1 is a critical regulator of developmental hematopoiesis and is expressed in all cell intermediates of EHT. Identification of the Runx1 +23 enhancer led to the devel
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Burkard, Michael. "Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367059.

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Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. Thi
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Fukuyama, Keita. "Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265181.

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Saucier, Caroline. "Identification, signaling, and agonist-induced down-regulation of endogenous serotonin-2 receptors in fibroblast cell lines : implication for cell growth." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ37019.pdf.

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Books on the topic "Mouse fibroblast cell lines"

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Al-Hakim, Abdallah. A role for the type 4 adenylyl cyclase isoform in forskolin-response pathway of Y1 mouse adrencortical tumor cell lines. National Library of Canada, 2003.

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Kunath, Tilo. Characterization of two distinct extraembryonic cell lines from the mouse blastocyst. 2003.

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Hamner, Steve. Characterization of growth of mouse mammary cell lines in collagen gel matrix and modulation of growth by cell-derived diffusible factors. 1985.

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Ward, Susan B. Analysis of Ig heavy chain transcripts from mouse myeloma cell lines: I. Sequence of the γ2b membrane 3' untranslated region and determination of poly(A) addition sites : II. Analysis of the heavy chain transcripts in the G403.4.7 cell line : A. The productive γ2b transcript : cis-alterations influence splice site selection : B. JH³ containing [mu] transcript : recent transcriptional activation of a different VH rearrangement. 1991.

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Joyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.

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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first
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Book chapters on the topic "Mouse fibroblast cell lines"

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Spielmann, H., I. Pohl, B. Döring, M. Liebsch, and F. Moldenhauer. "The embryonic stem cell test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embryonic stem cells." In Ersatz- und Ergänzungsmethoden zu Tierversuchen. Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-7500-2_69.

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Falciatori, Ilaria, Kate Lillard-Wetherell, Zhuoru Wu, F. Kent Hamra, and David L. Garbers. "Deriving Mouse Spermatogonial Stem Cell Lines." In Methods in Molecular Biology™. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-214-8_13.

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Medina, Daniel, and Frances Kittrell. "Establishment of Mouse Mammary Cell Lines." In Methods in Mammary Gland Biology and Breast Cancer Research. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-4295-7_13.

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Pfeiffer, Martin J., Martin Stehling, Anna Jauch, and Michele Boiani. "ES Cell Lines from Tetraploid Mouse Blastocysts." In Advances in Stem Cell Research. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-940-2_1.

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Choe, Tae-Boo, Jung-Keug Park, Jae-Ho Lee, and Eun-Kyoung Yang. "Development of Mouse Fibroblast Dermal Equivalent Using Tissue Culture Technique." In Animal Cell Technology: Basic & Applied Aspects. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2844-5_75.

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Tai, Guanping, Peter Hohenstein, and Jamie A. Davies. "Making Immortalized Cell Lines from Embryonic Mouse Kidney." In Kidney Development. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-851-1_15.

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Shi, Meng-Jiao, Kimberly Stencel, and Maria Borowski. "Passaging of Human Embryonic Stem Cells on Inactivated Mouse Embryonic Fibroblast Plates." In Human Stem Cell Technology and Biology. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470889909.ch9.

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Lee, Y. K., and P. K. Yap. "Isolation of Autocrine Growth Factors Producing Mouse Hybridoma Cell Lines." In Animal Cell Technology: Basic & Applied Aspects. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-2044-9_70.

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Froud, Stephen J., John Birch, Carol McLean, Alasdair J. Shepherd, and Kenneth T. Smith. "Viral Contaminants Found in Mouse Cell Lines Used in the Production of Biological Products." In Animal Cell Technology. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5404-8_107.

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Savan, Ram, Tim Chan, and Howard A. Young. "Lentiviral Gene Transduction in Human and Mouse NK Cell Lines." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-362-6_14.

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Conference papers on the topic "Mouse fibroblast cell lines"

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Hashimoto, Shigehiro, Kiyoshi Yoshinaka, and Hiroki Yonezawa. "Behavior of Cell Under Wall Shear Stress in Flow Field: Comparison Among Cell Types." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65205.

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Abstract Does the hysteresis effect remain in each cell after division? In the present study, the cell activity has been investigated after division under a shear stress field. To apply the constant shear stress field on cells, a Couette type flow device has been manufactured: between parallel walls (a lower stationary culture disk, and an upper rotating disk) with a constant gap. The wall shear stress was controlled by the rotating speed of the upper disk. Four types of cells were used in the test: C2C12 (mouse myoblast cell line), HUVEC (Human Umbilical Vein Endothelial Cells), 3T3-L1 (mouse
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Schiele, Nathan R., Douglas B. Chrisey, and David T. Corr. "Proliferation and Fiber Formation of Human Dermal Fibroblasts on Patterned Differentially Adherent Substrates." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192910.

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Fibroblast cells are crucial in the human body for maintenance of the extracellular matrix, including synthesizing macromolecules like collagen, and they play a critical role in wound healing of soft tissues such as skin [1]. Directing fibroblast growth is an important step in tissue engineering where the focus has gone from a top-down approach of homogeneously introducing cells into a pre-formed scaffold to a bottom-up approach in which the tissue construct is built on a cell-by-cell basis with ability to manipulate specific cell environments through location, proximity, and geometry. The abi
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Wha Lin, Shu, J. Ware, H. Roberts, N. McGraw, W. McAllister, and D. Stafford. "EXPRESSION OF HUMAN FACTOR IX IN MAMMALIAN CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643567.

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Human factor IX has been expressed in mammalian cells. A cloned factor IX cDNA missing the first 15 nucleotides of the 5’ end was modified by in vitro mutagenesis to restore the missing codons and add the translation consensus sequence, CCACC, proposed by Kozak to be optimal for translational initiation. Additionally, Bgl II and BamHI sites were added immediately upstream of the CCACC sequence for ease of portability of the fragment. This modified cDNA was inserted into a bovine papillomavirus (BPV) vector under the control of a mouse met alio thionein promoter. The constructed plasmid pBPV-IX
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Keyes, Joseph T., Stacy Borowicz, Urs Utzinger, Mohamad Azhar, and Jonathan P. Vande Geest. "Quantification of the Biomechanical Differences in Wild-Type and Heterozygous TGF Beta2 Knockout Mice." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19482.

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The use of transgenic mice is an incredibly powerful tool in understanding the underlying etiology of disease. To understand the usefulness of specific transgenic mice, the systems of interest should be characterized. We have created TGFβ2-deficient mouse fetuses that develop widespread aortic and coronary artery aneurysms [1]. Several studies have pointed to a strong connection between elevated TGFβ signaling and aortic aneurysm [2]. In situ hybridization has shown that Tgfb2 and Tgfb3 are major ligands expressed in the aortic medial wall. Further reduction of TGFβ signaling by combining TGFβ
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Varon, D., S. Linder, E. Gembom, L. Guedj, A. Berrebi, and Z. Eshhar. "MONOCLONAL ANTI-CYTOSKELETON ANTIBODY DERIVED FROM AN ITP PATIENT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644581.

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A monoclonal anti-platelet IcpI antibody was established by the fusion of splenocytes from Immune Thrombocytopenic purpura (ITP) patient with a human-mouse-hetercmyelcma cell line. The splenic lynphocytes were cultured with platelets and lipopoly saccharide for 9 days prior to fusion. Anti-platelet activity in the hybridcma supernatant was tested by the ELISA technique using plastic adherent platelets as antigen. Out of three hybridomas that demonstrated anti-platelets activity, one (4G9) appeared to be stable producer of IgM, was cloned and served for further characterizations. In immunofluor
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Su, Chih-Yuan, and Gou-Jen Wang. "Development of a Three-Dimensional Printer for Water-Soluble Biomaterial Printing." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85057.

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In this study, a three-dimensional bioscaffold printer was developed to fabricate biocompatible scaffolds from water-soluble materials for application in cell studies. A gelatin/sodium alginate solution was used to produce the scaffolds via a fused deposition modelling (FDM) printing method using the modified 3D printer. Modifications and improvements to the material feeding system, printing head, and printing platform were made, with additional optimization of the printing parameters, such as the feed rate, printing rate, and printing head size to investigate the precision and accuracy of two
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Nachman, R. L., R. L. Silverstein, and A. S. Asch. "THROMBOSPONDIN: CELL BIOLOGY OF AN ADHESIVE GLYCOPROTEIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644653.

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Thrombospondin (TSP), a multifunctional 450 KD glycoprotein is a secretory product of thrombin stimulated platelets. It is a major component of the platelets alpha granule constituting approximately 3% of total platelet protein. Thrombospondin does not circulate in appreciable concentrations ∽0 100 ng/ml); however, the tissue distribution is broad. In addition to its expression on the membrane of activated platelets, the protein is synthesized by fibroblasts endothelial cells, glial cell smooth muscle cells alveolar pneumocytes mononuclear phagocytes and various tumor cells. TSP is a major con
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Sewell-Loftin, M. K., and W. David Merryman. "The Role of SRC in Strain- and Ligand- Dependent Phenotypic Modulation of Mouse Embryonic Fibroblasts." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53604.

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Connective tissue fibrosis represents a significant portion of mortality and morbidity in our society. These diseases include many illnesses such as heart valve disease, atherosclerosis, macular degeneration, and cirrhosis, meaning that millions of lives are affected by these conditions each year. Fibrotic tissues form when quiescent fibroblasts activate becoming myofibroblasts, the phenotype of active tissue construction and fibrosis. During this process, the cells produce smooth muscle α-actin (αSMA), a contractile element considered to be the hallmark of cellular activation [1]. Following t
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Kacar, Sedat. "Effect of acrylamide on mitochondrial potential and cell cycle of fibroblast cell lines." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-45.

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Kanellakis, Nikolaos I., Theodora Agalioti, Dimitra Zazara, et al. "Mouse lung adenocarcinoma cell lines revealPrl2c2as a novel lung tumor promoter." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa4979.

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Reports on the topic "Mouse fibroblast cell lines"

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Rudolph, Michael C. Functional Characteristics of Tumor-Associated Protein Spot14 and Interacting Proteins in Mouse Mammary Epithelial and Breast Cancer Cell Lines. Defense Technical Information Center, 2010. http://dx.doi.org/10.21236/ada535489.

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Abstract:
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture indu
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Funkenstein, Bruria, and Shaojun (Jim) Du. Interactions Between the GH-IGF axis and Myostatin in Regulating Muscle Growth in Sparus aurata. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7696530.bard.

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Growth rate of cultured fish from hatching to commercial size is a major factor in the success of aquaculture. The normal stimulus for muscle growth in growing fish is not well understood and understanding the regulation of muscle growth in fish is of particular importance for aquaculture. Fish meat constitutes mostly of skeletal muscles and provides high value proteins in most people's diet. Unlike mammals, fish continue to grow throughout their lives, although the size fish attain, as adults, is species specific. Evidence indicates that muscle growth is regulated positively and negatively by
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