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1

Herschkowitz, Jason I. Perou Charles M. "Breast cancer subtypes, mouse models, and microarrays." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1728.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
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2

Lesurf, Robert. "Molecular pathway analysis of mouse models for breast cancer." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32499.

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Human breast cancer is an extremely heterogeneous disease, consisting of a number of different subtypes with varying levels of aggressiveness reflected by distinct, but largely undefined, molecular profiles. Here we have analyzed several novel mouse models for breast cancer in the context of the human subtypes, and have shown parallels between the mice and humans at numerous biologically relevant levels. In addition, we have developed a statistical framework to help elucidate the individual molecular comp
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3

Simpson, Peter Thomas. "Differential gene expression analysis in a transgenic mouse model of metastatic breast cancer." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343681.

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4

Alhazmi, Aiman. "Role of Nucleosome Remodeling Factor (NURF) in Tumorigenesis Using a Breast Cancer Mouse Model." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/379.

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Understanding the impact of epigenetic mechanisms on tumorigenesis is essential, as epigenetic alterations are associated with tumor initiation and progression. Because epigenetic changes are reversible, they are potential targets for cancer therapy. Nucleosome Remodeling Factor (NURF) is a chromatin-remodeling complex that regulates gene expression by changing nucleosome positioning along the DNA sequence. Previous studies have shown a role for NURF in embryonic development as well as regulating genes involved in tumor progression. In this work we investigated the impact of eliminating NU
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5

Robey, Ian, and Natasha Martin. "Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer." BioMed Central, 2011. http://hdl.handle.net/10150/610344.

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BACKGROUND:The glycolytic nature of malignant tumors contributes to high levels of extracellular acidity in the tumor microenvironment. Tumor acidity is a driving force in invasion and metastases. Recently, it has been shown that buffering of extracellular acidity through systemic administration of oral bicarbonate can inhibit the spread of metastases in a mouse model for metastatic breast cancer. While these findings are compelling, recent assessments into the use of oral bicarbonate as a cancer intervention reveal limitations.METHODS:We posited that safety and efficacy of bicarbonate could b
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Pochampalli, Mamata Rani. "Characterization of Effects of Muc1 Expression on Epidermal Growth Factor Receptor Signaling in Breast Cancer." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194355.

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EGF receptors are key regulators of cell survival and growth in normal and transformed tissues. Ligand binding results in formation of homo/hetero dimers of these receptors, followed by activation of the kinase activity and subsequent tyrosine phosphorylation of many downstream molecules. The activation of these receptors is not only mediated by the binding of their cognate ligands, but by transactivaton by other molecules as well. Recent studies have identified an oncogenic glycoprotein MUC1 as a binding partner for EGFR and that MUC1 expression can potentiate EGFR-dependent signal transducti
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Ke, Jia-Yu. "Bioactivity of Naringenin in Metabolic Dysregulation and Obesity-Associated Breast Cancer in a Mouse Model of Postmenopause." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437479457.

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8

Heilmann, Katharina [Verfasser], and Karin [Akademischer Betreuer] Müller-Decker. "Epigenetic characterization of the C3(1) SV40T mouse model of human breast cancer / Katharina Heilmann ; Betreuer: Karin Müller-Decker." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178008134/34.

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9

Balderstone, Lucy Anne. "Use of fluorescent imaging to monitor drug responses in mouse models of tumourigenesis." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17859.

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As our understanding of the complexities of cancer biology has increased, the ability to exploit unique features of tumour cells with molecularly targeted therapies has become a reality. However, despite unprecedented volumes of new molecules in clinical trials, the number of highly effective drugs approved by the regulatory authorities remains disappointingly low. Moreover, oncology drug development is plagued by high levels of attrition in late phase clinical development. Failure due to poor efficacy and toxicity issues are not believed to be a result of the development of molecules with ina
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10

Milliken, Erin L. "USE OF A TRANSGENIC MOUSE MODEL OF OVARIAN HYPERSTIUMLUATION TO IDENTIFY THERAPEUTIC TARGETS AND MECHANISMS IN HORMONE-INDUCED MAMMARY CANCER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1121273034.

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11

Mitterer, Chantal. "The role of inflammation induced by radiation or lipopolysaccharides in the metastatic process in a mouse model of breast cancer." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6343.

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Mortality from breast cancer is primarily due to metastatic disease, which often appears years after treatment of the primary tumor. Radiation as well as bacterial infection induces inflammation, which by releasing cytokines can be implicated in metastatic processes. Using in vitro and in vivo models, the ability of radiation to awaken dormant lung metastases was assessed as well as the capacity of a bacterial infection to enhance metastatic progression in already proliferating lung metastases. As models, we used the D2.0R (dormant) and D2A1 (proliferative) cell lines, which are derived from s
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12

Knostman, Katherine A. B. "Sodium/iodide symporter regulation by oncogenes in the mammary gland and thyroid gland using mouse models." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1181659993.

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13

PIETRELLA, LUCIA. "Establishment and characterization of new breast cancer cell lines from A∆16HER2 transgenic mouse: A promising model to test innovative therapies". Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401818.

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The human epidermal growth factor receptor 2 (HER2) is a validated therapeutic target in breast cancer therapy. However, increasing evidence points to a major role for the Δ16HER2 splice variant, which has been identified as a clinically important and tumor-specific HER2 molecular alteration promoting aggressive metastatic breast cancer and conferring resistance to anti-HER2 therapies. Δ16HER2 has an increased transforming potency compared to wild type HER2 receptor, since it promotes constitutive dimerization of the receptor and activation of Src-mediated oncogenic signaling pathways. Consi
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Alkhatib, Suehyb. "Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/376.

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Increasingly the role of epigenetic machinery as a bridge between underlying DNA sequence and cellular phenotype is being discovered. The establishment of a myriad of unique cellular types sharing identical gene sequences in a multicellular organism gives a broad sense for the inherent role of epigenetic influence on cell differentiation. Importantly, the epigenetic mechanisms involved in establishing cell identity unsurprisingly contribute to diseased states, including cancer. Recent research continues to elucidate contributory roles of epigenetic mechanisms, such as DNA methylation, histone
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15

Ordonez, Liliana. "Investigation of response and resistance to PARP inhibition in mouse models of human BRCA2-mutant breast cancer." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/68611/.

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Breast cancer is the most common cancer in the UK, but despite recent encouraging increases in survival rates, is still the second most common cause of cancer death in women in the UK. To try to reduce systemic toxicity during treatment of cancer patients, a plethora of targeted therapies are in various stages of development. PARP inhibitors have been shown to be particularly effective in BRCA-deficient cells, making them a contender as a personalised therapy. One of the challenges for targeted therapies is that of resistance, which limits the extent of benefit to the patient. The work describ
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Bolin, Celeste, Caleb Sutherland, Ken Tawara, Jim Moselhy, and Cheryl Jorcyk. "Novel mouse mammary cell lines for in vivo bioluminescence imaging (BLI) of bone metastasis." BioMed Central, 2012. http://hdl.handle.net/10150/610032.

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BACKGROUND:Tumor cell lines that can be tracked in vivo during tumorigenesis and metastasis provide vital tools for studying the specific cellular mechanisms that mediate these processes as well as investigating therapeutic targets to inhibit them. The goal of this study was to engineer imageable mouse mammary tumor cell lines with discrete propensities to metastasize to bone in vivo. Two novel luciferase expressing cell lines were developed and characterized for use in the study of breast cancer metastasis to bone in a syngeneic mouse model.RESULTS:The 4 T1.2 luc3 and 66c14 luc2 cell lines we
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Walker, Kelcey Manae Becker. "Inhibitory actions of Ah receptor agonists and indole-containing compounds in breast cancer cell lines and mouse models." Texas A&M University, 2002. http://hdl.handle.net/1969.1/2433.

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The aryl hydrocarbon receptor (AhR) binds synthetic and chemoprotective phytochemicals, and research in this laboratory has developed selective AhR modulators (SAhRMs) for treatment of breast cancer. Activation of the AhR through agonists such as TCDD inhibits hormone activation of several E2-responsive genes in breast cancer cell lines. In this study, inhibition of E2-induced proliferation and gene expression by TCDD has been investigated in the uterus of wildtype, ERKO and AhRKO mice. Cyclin D1, DNA polymerase ?, and VEGF mRNA levels are induced by E2 through ER? in the uterus as determine
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18

Collier, Jenna Lynn. "Investigation into the role of eosinophils in pulmonary metastasis and primary tumours in mouse models of breast cancer." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62442.

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Eosinophils are multifunctional granulocytes with potent immune modulatory and cytotoxic capabilities. Despite the presence of eosinophils in various solid tumours and eosinophilia being a prognosistic indicator in some cancers, the role of this innate immune cell has been largely overlooked in the context of cancer. Specifically, the role of eosinophils in pulmonary metastasis is poorly described despite their prevalence in the lung and association with various pulmonary diseases. I sought to delineate the role of eosinophils in murine models of metastatic breast cancer using novel mouse mode
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19

Creedon, Helen. "Use of genetically engineered mouse models in preclinical drug development." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15911.

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The paucity of well validated preclinical models is frequently cited as a contributing factor to the high attrition rates seen in clinical oncological trials. There remains a critical need to develop models which are accurately able to recapitulate the features of human disease. The aims of this study were to use genetically engineered mouse models (GEMMs) to explore the efficacy of novel treatment strategies in HER2 positive breast cancer and to further develop the model to facilitate the study of mechanisms underpinning drug resistance. Using the BLG--HER2KI-PTEN+/- model, we demonstrated th
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20

Chahrour, Ghada. "Estrogen-related receptor [alpha] (ERR[alpha]), estrogen receptor [alpha] (ERA[alpha]) and erbB-E (Neu) crosstalk in a mouse model of human breast cancer." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80237.

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Estrogen (17-beta estradiol) and its receptor (ERalpha) have important physiological roles and are well implicated in human breast cancer, but less is known about the function of estrogen-related orphan nuclear receptor alpha (ERRalpha). The close kinship between ERalpha and ERRalpha and the existing, but yet to be fully characterized, interplay between ERalpha and erbB2 (Neu) protooncogene signaling pathways, suggest that ERRalpha may also play a significant role in breast cancer. Thus, the focus of the current study was to determine the extent of ERRalpha cross talk with ERalpha, its
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21

Rossdeutscher, Lionel Philip David. "The role of tumoral 1,25 dihydroxyvitamin D3 in inhibition of tumor growth and progression in the PyVMT MMTV#634 transgenic breast cancer model /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112354.

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Vitamin D3 must be metabolically activated by the liver to 25-hydroxyvitamin D3 (25OHD3) and then by the kidney 1alphahydroxylase (1alphaOHase) to become 1,25dihydroxyvitamin D 3 (1,25(OH)2D3). 1,25(OH)2 D3 is a potent inhibitor of tumor growth in vitro and in vivo. Recent studies indicate that metabolic activation of 1,25(OH) 2D3 also occurs in cancer cells such as breast cancer. Consequently, the major objective of this project was to determine if tumoral 25OHD 3-1alphahydroxylase modulates any or all of the stages of breast tumor progression without inducing the hypercalcemic side effects o
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22

Ahmad, Fahmida. "Modelling heterogeneity of triple-negative breast cancer in mice to uncover and target signaling essentiality." Thesis, Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0225.

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Le cancer du sein triple négatif (TNBC) est un sous-type de cancer du sein très agressif et hétérogénène qui ne bénéficie actuellement d'aucun traitement efficace. Le but de mon projet de Thèse était d'explorer les mécanismes qui conduisent au TNBC pour concevoir de nouvelles approches thérapeutiques.Dans notre équipe, nous avons généré un modèle de souris unique (souris MMTV-R26Met) dans lesquelles le récepteur tyrosine kinase MET est faiblement augmenté. Elles développent spontanément et exclusivement des TNBC. Ce modèle récapitule la formation de métastases pulmonaires, la résistance aux ag
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Nanduri, Siva Lahiri Kanth [Verfasser], Ralph [Akademischer Betreuer] Witzgal, Christoph [Akademischer Betreuer] Klein, and Stephan [Akademischer Betreuer] Schneuwly. "Isolation and in vitro expansion of disseminated cancer cells from bone marrow of a transgenic mouse model of breast cancer / Siva Lahiri Kanth Nanduri. Betreuer: Ralph Witzgal ; Christoph Klein ; Stephan Schneuwly." Regensburg : Universitätsbibliothek Regensburg, 2014. http://d-nb.info/1068055642/34.

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24

FOY, KEVIN CHU. "COMBINATION IMMUNOTHERAPY WITH HER-2/NEU AND VEGF PEPTIDE MIMICS IN BOTH TRANSGENIC AND TRANSPLANTABLE MOUSE MODELS OF HUMAN BREAST CANCER." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299532419.

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GIANGRECO, GIOVANNI. "CHARACTERIZATION OF EPSIN3 FUNCTION IN THE ACQUISITION OF A PARTIAL EMT STATE IN BREAST CANCER THROUGH E-CADHERIN ENDOCYTOSIS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/605638.

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Epsin3 (EPN3) belongs to the Epsin family of endocytic adaptors, which in humans comprises 3 members: Epsin1 (EPN1), Epsin2 (EPN2) and EPN3. Differently from the other members, EPN3 is expressed at very low levels in almost all tissues and its function is unknown. Previous data have shown that EPN3 is overexpressed in about 47% of breast cancers, correlating with an aggressive tumor phenotype and increased risk of distant metastasis. At the cellular level, in vitro studies performed on MCF10A, a non-tumoral immortalized breast epithelial cell line, showed that overexpression of EPN
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Pérez, lanzón María. "Modeling Hormone Receptor Positive Breast Cancer in Immunocompetent Mice Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression Organoids for Modeling Genetic Diseases. In: International Review of Cell and Molecular Biology A preclinical mouse model of osteosarcoma to define the extracellular vesicle-mediated communication between tumor and mesenchymal stem cells Failure of immunosurveillance accelerates aging The metabolomic signature of extreme longevity: Naked mole rats versus mice Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL019.

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Les progrès de la recherche sur le cancer du sein dépendent de la disponibilité d’outils appropriés, comme les lignées cellulaires qui peuvent être implantées chez des souris immunocompétentes. La souche de souris C57Bl/6 est la plus étudiée et c’est la seule pour laquelle certaines variantes génétiques sont disponibles. Étant donné qu'aucune lignée cellulaire de carcinome mammaire à récepteurs hormonaux positifs de souche C57Bl/6 n'est disponible, nous avons décidé d'établir des lignées cellulaires de ce type. Nous avons induit des cancers du sein chez des souris C57BL/6 femelles en utilisant
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Vallerand, David. "Etude du stroma de tumeurs mammaires humaines xénogreffées et de modèles transgéniques murins." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T001.

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La progression tumorale est un processus multi-étapes dépendant notamment des interactions entre les cellules cancéreuses et le stroma environnant. Le développement du cancer du sein implique une communication étroite entre les cellules épithéliales mammaires, les cellules inflammatoires, les myofibroblastes et les cellules endothéliales. Ainsi, le microenvironnement tumoral apparaît comme une cible de choix dans le traitement anti-tumoral. L’utilisation de modèles précliniques est une étape clé dans le développement et la validation de nouvelles thérapies. Néanmoins, peu d’études sont disponi
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Scully, Jaqueline Susan. "Insertion of oncogenes into mouse mammary epithelium." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315287.

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Chambers, Julie Anne. "Analysis of the BRCA1 region in human and mouse." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298465.

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Abram, Clare L. "Expression of oncogenes in mouse mammary epithelium by transplantation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307957.

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31

Worrall, Lisa Kirsty. "A 3D in vitro breast cancer model." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436812.

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32

Kishi, Masae. "Strategies of Cancer Immunotherapy : Model of Triple Negative Breast Cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS070.

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Les cellules souches cancéreuses (CSC) sont à l’origine de la progression tumorale, des métastases et rechutes tardives. Elles ont été identifiées dans de nombreux cancers, comme le cancer du sein triple négatif (TNBC) et cancers de grade III-IV. Elles sont résistantes aux chimiothérapies et radiothérapie et résident dans une niche immuno-répressive. Cette étude vise à évaluer une stratégie d’immunothérapie qui cible sélectivement les CSC dans le modèle murin 4T1-GFP-Luc mimant le TNBC. Le phénotype/ génotype des mamosphères a été initialement caractérisé. Basée sur l’analyse génomique des CSC
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Kishi, Masae. "Strategies of Cancer Immunotherapy : Model of Triple Negative Breast Cancer." Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS070.

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Les cellules souches cancéreuses (CSC) sont à l’origine de la progression tumorale, des métastases et rechutes tardives. Elles ont été identifiées dans de nombreux cancers, comme le cancer du sein triple négatif (TNBC) et cancers de grade III-IV. Elles sont résistantes aux chimiothérapies et radiothérapie et résident dans une niche immuno-répressive. Cette étude vise à évaluer une stratégie d’immunothérapie qui cible sélectivement les CSC dans le modèle murin 4T1-GFP-Luc mimant le TNBC. Le phénotype/ génotype des mamosphères a été initialement caractérisé. Basée sur l’analyse génomique des CSC
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34

Meaney, Mary Patricia. "The growth of murine breast cancer cells in dystrophic mice." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/40177.

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The American Cancer Society predicted that 230,480 women would be diagnosed with, and 39,520 women would die from breast cancer (BC) in the United States in 2011. While the incidence of female BC has been decreasing, BC remains the second leading cause of cancer death among women in the United States. Cancer cachexia, the cancer-related loss of muscle, affects up to 25% of BC patients and is associated with poor prognosis and decreased quality of life. Alterations to the dystrophin glycoprotein complex (DGC), a transmembrane, multi-subunit protein complex with structural and signaling roles, h
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Jones, Christina Michele. "Applications and challenges in mass spectrometry-based untargeted metabolomics." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54830.

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Metabolomics is the methodical scientific study of biochemical processes associated with the metabolome—which comprises the entire collection of metabolites in any biological entity. Metabolome changes occur as a result of modifications in the genome and proteome, and are, therefore, directly related to cellular phenotype. Thus, metabolomic analysis is capable of providing a snapshot of cellular physiology. Untargeted metabolomics is an impartial, all-inclusive approach for detecting as many metabolites as possible without a priori knowledge of their identity. Hence, it is a valuable explorato
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Bobick, Todd M. "Transtheoretical model and exercise in breast cancer survivors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0020/MQ47009.pdf.

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Fazeli, Amin. "Construction of a mouse model of colon cancer." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43348.

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Cong, Chunling. "Statistical Analysis and Modeling of Breast Cancer and Lung Cancer." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3563.

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The objective of the present study is to investigate various problems associate with breast cancer and lung cancer patients. In this study, we compare the effectiveness of breast cancer treatments using decision tree analysis and come to the conclusion that although certain treatment shows overall effectiveness over the others, physicians or doctors should discretionally give different treatment to breast cancer patients based on their characteristics. Reoccurrence time of breast caner patients who receive different treatments are compared in an overall sense, histology type is also taken into
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Patino, Patricia. "Breast cancer: Relationship between acculturation and barriers to breast cancer screening in Southwest Florida Latinas." Scholar Commons, 2006. http://scholarcommons.usf.edu/etd/2656.

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Despite multiple campaigns by the American Cancer Society, reports indicate that Latinas living in the United States who contract breast cancer are more likely than Anglos to die. These findings correlate with low participation in breast cancer screenings among Latinas. The objective of this study was to identify key obstacles that influence Latinas' low participation in breast cancer screenings, based on their health beliefs, knowledge of screenings, acculturation, and socio-economic factors.The study was a face-to-face informal interview, combined with a survey questionnaire conducted at chu
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Želvienė, Aušra. "Women beliefs towards breast cancer, breast self-examination and mammography in connection with participation in breast cancer screening." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2008. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20080129_121108-78281.

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The aim of the study is to assess the connection between women’s participation in breast cancer screening and beliefs towards breast cancer, breast self-examination and mammography. The objectives of the study: 1. To assess validity and reliability of Champion Health Belief Model Scale for beliefs towards breast cancer, breast self-examination and mammography screening for Lithuanian women. 2. To estimate perceived susceptibility, perceived severity, perceived benefits, perceived barriers, confidence and health motivation. 3. To compare beliefs towards breast cancer, breast self-examination an
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Wang, Ying. "Mouse Models of Menopause and Ovarian Cancer Risks." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/681.

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Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in Western countries. A better understanding of the etiology and risk factors associated with this disease is crucial for the development of early detection protocols as well as more effective therapies. Epidemiological data has shown that the risks of EOC are highest among peri- or post- menopause women, while increased parity or the use of oral contraceptives is preventive. These data suggest that alterations in reproductive factors are associated with ovarian cancer risks; however, the molecular mec
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Kim, Jong Bin. "Development of a fully "humanized" xenograft model of breast cancer." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444826/.

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Until now there has been a distinct lack of a truly representative breast cancer model. The development of a complex heterologous multi-compartment xenograft model incorporating the relevant stromal elements will provide a realistic alternative to currently available chimeric xenograft models. The recent ability to immortalize primary human mammary endothelial cells and fibroblasts by the insertion of the hTERT and a temperature sensitive mutant variant of SV40 LT has made this possible. We have commenced the development of an organotypic, 3-compartment xenograft model of human breast cancer.
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Clifford, Adrianne Brown. "Tumor Associated Macrophages in a MaFIA Mouse Model." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1427.pdf.

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Lawson, Jessica Clair. "Analysis of the anti-cancer activity of novel indigenous algal compounds in breast cancer: towards the development of a model for screening anti-cancer stem cell activity." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003984.

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Breast cancer, the most common malignancy diagnosed in women, is one of the leading causes of death in women worldwide. In South Africa only 32% of women diagnosed with advanced breast cancer survive more than five years. The search for new chemotherapeutic agents capable of effectively treating breast cancer is therefore essential. Recent evidence supporting the cancer stem cell theory of cancer development for breast cancer challenges the current theories of cancer development and hence treatment. Cancer stem cells are a small subpopulation of tumour cells that possess properties of both can
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Moyo, Buhle. "The screening and characterisation of compounds for modulators of heat shock protein (Hsp90) in a breast cancer cell model." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1004129.

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Breast cancer is a leading cause of cancer death in Africa. Hsp90 has been identified as a target for anti-cancer treatments as its inhibition results in the disruption and ubiquitin–proteasome degradation of activated oncoproteins. Currently, there are no US Food and Drug Administration approved Hsp90 inhibitor drugs and existing Hsp90 inhibitors such as geldanamycin and novobiocin are hepatotoxic and display a low affinity for Hsp90, respectively. Therefore, there is a need for the development of Hsp90 inhibitors with improved inhibitory properties. In this study twelve natural compounds bea
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46

An, Wenxin, and 安文欣. "Validation studies of the Gail Model for breast cancer : a systematic review." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206924.

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Background: The Gail Model is a statistical and risk assessment tool for women with given age and risk factors to estimate their probability that will develop invasive breast cancer. An accurate assessment of individual risk for developing breast cancer would be useful for health care providers to facilitate their risk communication with women at average risk and to make decision on taking chemoprevention for high-risk women in clinical practice. Currently, there are several validation studies of the Gail Model in western populations, however, model validity on Chinese people has not yet to be
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47

Antoniou, A. C. "Developing a comprehensive risk model for familial breast and ovarian cancer." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596129.

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The specific aim of this thesis was to combine data on mutation prevalence and risk from both high risk families and population based series, in order to develop a model for familial breast and ovarian cancer which incorporates both the effects of BRCA1, BRCA2 and other genes. The principal methodology used was segregation analysis and the genetic models were constructed using the computer program MENDEL. The first dataset consisted of 112 families containing two or more relatives with epithelial ovarian cancer. BRCA1 and BRCA2 germline mutations were detected in 50% of these families. When th
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48

Titova, A. Yu. "Fuzzy Model Thermal Image Analysis for Detection Breast Cancer in Women." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47075.

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Fuzzy model thermal image analysis diagnostic information system was described. Input and output linguistic variables of fuzzy model of information system diagnostic of breast cancer in women were characterized. Selection of membership functions was realized. Fuzzy knowledge base was created on the basis of expert statements.
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49

RITELLI, Rossana. "Generating a pancreatic cancer mouse model: from Cancer Stem Cells to in vivo imaging strategies." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/344615.

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Presupposti: nonostante gli enormi sforzi della ricerca per lo studio del carcinoma del pancreas, a tutt’oggi questo tumore aggressivo rimane incurabile e necessita di terapie mirate che garantiscano un miglioramento concreto della qualità della vita dei pazienti. Pertanto, è forte il bisogno di creare un sistema efficace e mirato all’identificazione di nuovi composti per la cura del cancro del pancreas. Scopo: lo scopo di questo lavoro è quello di contribuire alla generazione di un sistema che porti selezione di nuovi composti per il trattamento del carcinoma pancreatico. Questo sistema
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Bagshaw, Rachel Jane. "Expression and inhibition of subclass I receptor tyrosine kinases in a rat mammary model." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260352.

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