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Journal articles on the topic 'Mouth Dissolving Tablets And Bioavailability'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Santosh Kumar, Rada, and Annu Kumari. "Superdisintegrant: crucial elements for mouth dissolving tablets." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 461–68. http://dx.doi.org/10.22270/jddt.v9i2.2480.

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Mouth dissolving tablets have gained more popularity among solid oral dosage forms. They perform better than conventional tablets because of its ease of administration and patient’s compliance. It facilitates water less administration and rapid onset of action. It also helps in improving oral bioavailability. The fast disintegration followed by dissolution leads to quick therapeutic activity makes these tablets superior over available tablets and capsules. Disintegration is an important key step for any solid dosage forms to show its pharmacologic effect as any solid dosage forms should disper

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2

R., Santosh Kumar and Sahithi Mudili. "A REVIEW ON TECHNOLOGIES EMPLOYED IN FORMULATION OF MOUTH DISSOLVING TABLETS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 890–902. https://doi.org/10.5281/zenodo.1181454.

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Oral route is the most preferred route for administration of various drugs because it is regarded as safest, most convenient and economical route. Recently researcher developed the mouth dissolving tablets with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. Mouth dissolving tablets overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in paediatric and geriatric patie

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3

Ansari, K. Kareemuddin, and Neeraj Sharma. "Formulation and evaluation of orodispersible tablets of lornoxicam." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 225–28. http://dx.doi.org/10.22270/jddt.v8i6.2058.

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Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Lornoxicam using KYRON T-314 (Polacrillin Potassium) as a novel superdisintegrant. Mouth dissolving tablets of lornoxicam were prepared by wet granulation technique using KYRON T-314 as superdisintegrant and menthol as subliming agent. The present study demonstrated potentials for rapid absorption, improved bioavailability, ef

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4

A V, Misal, G. R. Godage, and S. A. Belge. "Current Progress in the Formulation and Taste-Masking Technologies for Mouth Dissolving Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 9, no. 5 (2016): 3452–57. http://dx.doi.org/10.37285/ijpsn.2016.9.5.2.

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Within the past one decade, mouth dissolving or fast disintegrating tablet technology has received ever-increasing demand. Mouth dissolving or fast disintegrating tablet can be defined as a solid dosage form that can disintegrate or dissolved within half-minute in the oral cavity resulting in a solution or suspension without administration of water. Mouth dissolving tablet have been formulated for pediatric, geriatric, bedridden patient or mentally ill patient and may not have access to water. Patient incompliance occurs due to bitterness of formulation. So masking the bitterness become in dis

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Sahasrabuddhe, Vishakha, M. Alagusundaram, Vijeta Bhattacharya, Namrata Mishra, and Priyanka Keshri. "Formulation and Evaluation of Ascorbic Acid Mouth Dissolving Tablets." Asian Journal of Basic Science & Research 06, no. 02 (2024): 167–82. http://dx.doi.org/10.38177/ajbsr.2024.6213.

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Mouth dissolving tablet have better accessibility and tolerability for patients, mouth dissolving tablet is the most essential and recommended way of drug delivery. One more difficulty can be solved by administering the new drug with the mouth dissolving tablet formulation so that the drug quickly dissolves and breaks in the mouth in fewer minute due to the effect of super disintegrating agents that maximize the pore structure of the formulation. The purpose of this research work was to develop mouth-dissolving tablet of Ascorbic Acid. Tablet containing drug and excipients were prepared by dir

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Venkateswara, Rao. S* Rodhay. G. &. Padmalatha. K. "DESIGN AND EVALUATION OF MOUTH DISSOLVING TABLETS OF TELMISARTAN BY USING DIFFERENT SUPER DISINTEGRANTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 09 (2017): 707–23. https://doi.org/10.5281/zenodo.1036331.

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The present research was carried out to develop mouth dissolving tablets using superdisintegrants and improve the solubility ultimately bioavailability of Telmisartan by encapsulating it inside the cavity of β-cyclodextrin. Mouth dissolving tablets improve the oral bioavailability by enhancing the drug disintegration and release of drug particles from the dosage form, which enable quick and direct delivery into the circulatory system by avoiding first pass metabolism. Total nine batches of mouth dissolving tablets were prepared using superdisintegrants like Crosscarmellose sodium (CCS), Sodium

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Aniket, G. Karodade, P. Wable Aniket, kharbal Gopal, S. Bhagat Sunil, and P. Deshmukh Swati. "Fast dissolving tablet." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 001–7. https://doi.org/10.5281/zenodo.11951879.

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Fast dissolving tablets have emerged as a popular dosage form, particularly beneficial for pediatric and geriatric patients facing challenges such as dysphagia or hand tremors. These tablets dissolve quickly in saliva without needing water, enhancing compliance and effectiveness of therapy. They offer advantages like easy portability, accurate dosing, and improved bioavailability. Various technologies, including spray drying and melt granulation, have been developed for their manufacturing. This review provides comprehensive information on fast dissolving tablets, covering their definition, ad

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*Ramachandra, M. Koli Ritesh S. Bathe Rupali V. Hirave Santosh S. Ghutukade Gosavi Rohit S. Bharat B.Garande. "FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ALBENDAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6572–85. https://doi.org/10.5281/zenodo.1318585.

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<em>Albendazole is an oral broad spectrum anthelmintic, antiparasitic agent generally prescribed for the treatment of tissue infections caused by a variety of namatodes, Threadworm, Hookworm, and Tapeworm. It has low bioavailability due to its first pass metabolism. It is water insoluble drug. The purpose of the present research work was to formulate and evaluate the mouth dissolving tablets of Albendazole by direct compression method using different superdisintegrants like sodium starch glycolate, croscarmellose sodium, and crospovidone in different concentrations. FT-IR spectroscopy was used

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Aniket G. Karodade, Aniket P. Wable, Gopal kharbal, Sunil S. Bhagat, and Swati P. Deshmukh. "Fast dissolving tablet." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 001–7. http://dx.doi.org/10.30574/gscbps.2024.27.1.0096.

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Fast dissolving tablets have emerged as a popular dosage form, particularly beneficial for pediatric and geriatric patients facing challenges such as dysphagia or hand tremors. These tablets dissolve quickly in saliva without needing water, enhancing compliance and effectiveness of therapy. They offer advantages like easy portability, accurate dosing, and improved bioavailability. Various technologies, including spray drying and melt granulation, have been developed for their manufacturing. This review provides comprehensive information on fast dissolving tablets, covering their definition, ad

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10

Singh, Swati, Rajat Pawar, and Sunita Patidar. "A REVIEW ON MOUTH DISSOLVING FILM- A NOVEL APPROACH." International Journal of Pharmaceutical Sciences and Medicine 9, no. 2 (2024): 36–51. http://dx.doi.org/10.47760/ijpsm.2024.v09i02.006.

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The oral route is one of the most important routes for local and systemic drug delivery due to its large surface area, high permeability and blood flow. Mouth dissolving films are the most advanced oral forms as they are simpler and easier to use than other dosage forms such as Oro-soluble tablets, sublingual tablets. Fast dissolving drug delivery system were rapidly developed in the 1970s as an alternative to capsules, syrups, and tablets for adults and adolescents who have difficulty swallowing conventional oral solid dosage form. The Oro- soluble film dissolves and disintegrates in less tha

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Sharma, Shanu, Vivek Chauhan, Neha, and M. Khalid Khan. "Formulation optimization of mouth dissolving tablets of Meloxicam using mixed hydrotropic solublization technique." Journal of Scientific and Innovative Research 4, no. 2 (2015): 76–82. http://dx.doi.org/10.31254/jsir.2015.4206.

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The objective of the present study was to develop mouth dissolving tablets of meloxicam in order to achieve rapid release in saliva which may result in enhanced absorption and thereby improved bioavailability. Six batches of mixed hydrotropic solid dispersions and physical mixtures were prepared using different ratios (1:2, 1:4 and 1:6) of hydrotropic blends (urea, Nicotinamide & sodium citrate). The best batch was selected to prepare mouth dissolving tablets comprising solid dispersion of Meloxicam in six preliminary batches using croscarmellose sodium & crospovidone as superdisintegr

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Shahul, Hameed K. M* Arun Kumar M. and Dhanapal C. K. "SELECTION OF A SUITABLE METHOD FOR THE PREPARATION OF TADALAFIL MOUTH DISSOLVING TABLETS: MULTI-CRITERIA DECISION MAKING APPROACH." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3220–27. https://doi.org/10.5281/zenodo.1256039.

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Recent advances in Novel Drug Delivery Systems (NDDS) aim for designing dosage forms, convenent to be manufactured and administered, free of side effects, offering immediate release and enhanced bio availability, so as to achieve better patient compliance. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop mouth dissolving tablets with improved patient compliance and convenience. Yet, dysphagia is the most common disadvantage of conventional tablets. Advantages of this drug delivery syste

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Pommala, Nagaveni* A. Sreevalli G. Syam Sundar. "Fast Dissolving Tablets: An Overview." Int. J. in Pharm. Sci. 1, no. 7 (2023): 235–45. https://doi.org/10.5281/zenodo.8155035.

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The oral route is now the industry standard for drug delivery as it is recognized as the safest, least expensive, and most convenient method of achieving patient compliance. Rapidly dissolving tablets, a new idea for oral administration, is widely used and now accepted. These are solid dosage forms that dissolve and release the active ingredient when placed in the mouth without water for a short period of time. Geriatric, paediatric and bedridden patients are particularly favoured for the use of these FDTs because of dysphagia. Rapid absorption, quick onset of action and less drug loss propert

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14

Sagar, T. Malsane, S. Aher Smita, and B. Saudagar R. "A Review on Fast Dissolving Tablet." International Journal of Current Pharmaceutical Review and Research 9, no. 3 (2017): 284–92. https://doi.org/10.5281/zenodo.12674645.

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Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economicaland most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orallydisintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly peopleexperience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions becauseof tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack orc

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Sagar, T. Malsane, S. Aher Smita, and B. Saudagar R. "A Review on Fast Dissolving Tablet." International Journal of Current Pharmaceutical Review and Research 8, no. 3 (2017): 284–92. https://doi.org/10.5281/zenodo.12677626.

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Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economicaland most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orallydisintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly peopleexperience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions becauseof tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack orc

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16

Singh, Sudarshan, S. S. Shyale, and G. Bhosale. "Formulation and Evaluation of Mouth Dissolving Tablets of Piroxicam." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 3 (2015): 2941–46. http://dx.doi.org/10.37285/ijpsn.2015.8.3.8.

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Piroxicam, a non-steroidal anti-inflammatory agent, is widely used in rheumatoid arthritis, osteoarthritis, musculo-skeletal disorders, dysmenorrhoeal and post-operative pain. It has poor bioavailability due to its inherent properties. The objective of present study is to enhance water solubility of Piroxicam by solid dispersion technique and to develop novel method of preparing compressed tablets for Piroxicam with high porosity which dissolves rapidly in mouth, using camphor as sublimating agent and super disintegrants such as Crosscarmellose sodium and sodium starch glycollate. The tablets

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17

Sakshi, D. Patil* Shubhangi S. Ambekar Sandip A. Tadavi Sunil P. Pawar. "Review On Mouth Dissolving Film: The Advancement In Oral Drug Delivery." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 559–68. https://doi.org/10.5281/zenodo.10824195.

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Mouth dissolving films are the kind of drug delivery system which is gaining interest from a wide range of pharmaceutical industries. This is due to there  convenience and it’s easy to use than other dosage forms like buccal tablets and sublingual tablets. By studying transdermal patch technology, mouth dissolving film was formulated. Thin, solid dosage forms called mouth dissolving films dissolves in the mouth within seconds to a minute without chewing or water intake. Because of the oral buccal mucosa's high vascularization, medications can be absorbed immediately and reach the bl

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18

Hitendra, S. Mahajan. "Development and Evaluation of Rutin-HPβCD Inclusion Complex Based Mouth Dissolving Tablets". International Journal of Pharmaceutical Sciences and Developmental Research 3, № 1 (2018): 001–6. https://doi.org/10.17352/ijpsdr.000009.

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The objective of the present study was to explore inclusion complex of Rutin to improve the aqueous solubility and dissolution rate along with rapid mouth dissolving tablets for oral drug delivery. Rutin is a BCS class II drug having low aqueous solubility and therefore low oral bioavailability. In the present study, inclusion complex of rutin with hydroxypropyl-b-cyclodextrin were prepared by kneading method. Inclusion complex were characterized by 1H NMR, X-ray diffractometry (XRD), differential scanning calorimetry (DSC) studies, and Fourier transform infrared spectroscopy and evaluated for

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Jovanovic, Dusan, Vesna Kilibarda, Veljko Todorovic, and Olivera Potrebic. "A pharmacokinetic comparison of three pharmaceutical formulations of nimesulide in healthy volunteers." Vojnosanitetski pregled 62, no. 12 (2005): 887–93. http://dx.doi.org/10.2298/vsp0512887j.

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Background/Aim. Switching the patient from one pharmaceutical formulation of the same drug to another, may lead to therapeutic inadequancy in some cases. To minimize the risk, careful pharmacokinetic studies are desired in the pre-registration period and afterwards. Methods. A randomized, crossover design with one-week wash-out period between each dose was applied. Serum samples, obtained before dosing and at various appropriate time points up to 15 hours, were analyzed for nimesulide content by a high-performance liquid chromatographic method with ultraviolet (UV) detection. The pharmacokinet

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20

Sengar, Ashutosh. "Chewable Tablets and Mouth-Dissolving Films Revolutionizing Drug Administration." International Journal of Biomedical and Clinical Analysis 5, no. 1 (2025): 29–34. https://doi.org/10.61797/ijbca.v5i1.452.

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Oral drug delivery has evolved a lot in terms of patient compliance, bioavailability, and therapeutic action. The present review integrates advancements in chew tablets and mouth-dissolving films according to their formulation strategy, merits and application in pediatric and geriatric patients. They improve patient compliance due to good solubility and quick action. Nanotechnology has been a central force in drug delivery system transformation. Liposomal drug carriers, polymer therapeutic carriers and nanoparticle formulations have enabled the increase in solubility, controlled release and si

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Singh, Gajendra, Gyan Singh, and Jitender K. Malik. "Design and Development of Terbutaline Sulphate Fast Mouth Dissolving Tablet." South Asian Research Journal of Pharmaceutical Sciences 4, no. 5 (2022): 96–104. http://dx.doi.org/10.36346/sarjps.2022.v04i05.002.

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Asthma is a chronic inflammatory disease that causes an associated increase in airway hyperreactivity leading to recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, especially at night and early in the morning. Terbutaline sulfate is a selective beta2 adrenergic agonist. It is highly selective for β2 adrenergic receptors and has a long-lasting effect. It is given for symptomatic relief of bronchospasm and obstructive airway disease. Terbutaline sulfate is effective when taken orally, subcutaneously, or by inhalation. Although effects are rapidly observed after i

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Agarwal, Shivendra, and Raghvendra Misra. "A REVIEW ON: FORMULATION, TECHNOLOGICAL AND BENEFICIAL ASPECTS OF ORAL DISPERSIBLE TABLETS." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 1 (2023): 92–99. http://dx.doi.org/10.48165/ijppronline.2023.14108.

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This review is about oral dispersible tablets a novel approach in drug delivery systems that are now a day’s more focused in formulation world, and laid a new path that, helped the patients to build their compliance level with the therapy, also reduced the cost and ease the administration especially in case of pediatrics and geriatrics. Oral dispersible tablets are advantageous for pediatric, geriatric mentally ill, nausea patients who have difficulty in swallowing conventional tablets and capsules. Using various excipients, evaluation tests marketed formulation and drugs used in the research

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Birajdar, Shivprasad M., Omprakash G. Bhusnure, and Suraj S. Mulaje. "FORMULATION AND EVALUATION OF FAST DISINTEGRATING LOSARTAN POTASSIUM TABLETS BY FORMAL EXPERIMENTAL DESIGN." International Journal of Drug Regulatory Affairs 2, no. 2 (2018): 61–77. http://dx.doi.org/10.22270/ijdra.v2i2.132.

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In the treatment of hypertension fast onset of action is the major concern. The problem of slow onset of action of drugs can be overcome by development of appropriate dosage forms. Fast disintegrating tablets in mouth are best suited and have gained popularity in the oral antihypertensive drug therapy. These are advantageous over other conventional systems in terms of patient compliance, rapid onset of action, accurate dosing, good chemical stability, convenience of self-administration and compactness. Losartan potassium is widely used as an antihypertensive drug, which is a potent drug candid

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Khan, MD Abdul Aali, M. S. Sudheesh, and Rajesh Singh Pawar. "Formulation Development and Evaluation of Oro-Dispersible Tablets Based On Solid Dispersion of Cimetidine." Journal of Drug Delivery and Therapeutics 12, no. 6-S (2022): 42–46. http://dx.doi.org/10.22270/jddt.v12i6-s.5696.

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The most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained. The objective of present study was to f

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Abid, Md Ather Ahmed, and Saritha Chukka. "Formulation And Evaluation Of Rizatriptan Benzoate Mouth Dissolving Tablets Using Natural Superdisintegrants." Journal of Neonatal Surgery 14, no. 32S (2025): 3405–11. https://doi.org/10.63682/jns.v14i32s.7940.

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Introduction: Rizatriptan benzoate is a new generation anti-migraine drug, potent and selective 5-hydroxy tryptamine 1B/1D receptor agonist used for the treatment of acute migraine attack. The bioavailability of Rizatriptan benzoate is about 45%. The half-life is 2 to 3 hours. The aim of the study was to formulate Rizatriptan benzoate mouth dissolving tablets (MDT) to enhance the dissolution rate to facilitate quick onset of action. Methods: Total nine formulations were developed by direct compression method using three natural super-disintegrants. DSC was conducted to study the drug-excipient

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Prajapati, Vinitbhai*1 Himanshu Sharma2 Sagar Patra3 Sahilahmad Makarani3 Mahendrakumar Dubey1. "A Contemporary Approach to The Medicate Conveyane Through Orodispersible Tablets." International Journal of Scientific Research and Technology 1, no. 12 (2024): 29–40. https://doi.org/10.5281/zenodo.14285188.

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The development of dosage forms that are easy to manufacture and administer, as well as rapid release and increased bioavailability, have led to new drug delivery systems. To achieve the desired result, drugs must be delivered to the site of action at a speed and concentration that maximizes therapeutic benefits and minimizes side effects. The most popular and efficient way of drug administration is oral. Recently, many medicinal products have been released in the market. The use of lyophilizers and oral tablets or films have expanded treatment options. Both children and adults can benefit fro

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Naji, Ghada Hamid, Worood Hameed Al-Zheery, and Noor Yousif Fareed. "DESIGN AND IN VITRO EVALUATION OF ACRIVASTINE AS ORODISPERSIBLE TABLET USING DIRECT COMPRESSION METHOD." Wiadomości Lekarskie 76, no. 1 (2023): 170–74. http://dx.doi.org/10.36740/wlek202301123.

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The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability. Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made

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Disha, Wankhede* Damini Mundhare. "Formulation And Evaluation Of Oral Dispersible Tablet Containing Giloy." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 342–50. https://doi.org/10.5281/zenodo.14045993.

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Tablets, the most common drug delivery system, provide the opportunity to incorporate new technologies to produce more dosage forms. Orally dispersible drug delivery systems are widely used to improve bioavailability and patient compliance. Orally dispersible tablets (ODT) have been developed for children, the elderly, bedridden patients, and patients without access to water. In fact, swallowing problems develop in young people due to weakening of muscles and nerves. In some cases, such as cold, cough and inability to drink, tablets may be difficult or uncomfortable to swallow. ODT creates a s

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Mishra, Soumya, Nidhi Bais, and Sachin Kumar Jain. "Formulation and Evaluation of Mouth Dissolving Film of Imipramine HCL." Journal of Biomedical and Pharmaceutical Research 12, no. 4 (2023): 22–29. http://dx.doi.org/10.32553/jbpr.v12i4.1015.

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The main objective of the present study outlines a systematic approach for Design and Evaluation of Fast Dissolving Oral Films of Imipramine HCl to enhance the therapeutic efficacy and provide rapid onset of action in patients suffering from depression Because of patient may have trouble in swallowing a tablet or capsules. Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage for

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R, Karthik D., H. S. Keerthy, and Rajkumar Prasad Yadav. "A Review on Fast Dissolving Oral Films." Asian Journal of Pharmaceutical Research and Development 9, no. 3 (2021): 122–28. http://dx.doi.org/10.22270/ajprd.v9i3.969.

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Oral route are the most convenient and common route of administration of drug because of the low cost of therapy and ease of administration lead to high levels of patient compliance as in the form of tablets and capsules. Generally In some cases, the oral solid dosage form may become difficult especially in swallowing. So to overcome these problems, fast dissolving drug delivery systems have been developed which disintegrate or dissolve within one minute when placed in the mouth without water or chewing. These are the formulations administered without water. These thin sized oral film stripes

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Senthil, S. P. "FORMULATION AND INVITRO EVALUATION OF MOUTH MELTING TABLETS OF TELMISARTAN USING NATURAL SUPERDISINTEGRANT." YMER Digital 21, no. 03 (2022): 300–312. http://dx.doi.org/10.37896/ymer21.03/33.

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This tablet is formulated by direct compression method by using natural superdisintegrant such as Hibiscus and Fenugreek for the benefits of agents which make the drug disintegrate rapidly in water by wicking or swelling or by any other mechanisms This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In recent years, several newer agents have been developed known as superdisintegrants. Diverse categories of superdisintegrants such as synthetic, semisynthetic, natural and co-processed blends etc. have been employed

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Vaishali, Mukhmale* Aijaz Sheikh Kailash Biyani. "Formulation and Evaluation of Mouth Dissolving Film (MDFs) Containing Active Pharmaceutical Ingredient (API)." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2121–26. https://doi.org/10.5281/zenodo.15397518.

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As an empiric therapy for nausea and vomiting, ondansetron is among the most often prescribed drugs.  The antiemetic properties of ondansetron make it a useful medicine for treating nausea and vomiting caused by a wide range of conditions.  Ondansetron is commonly used to reduce nausea and vomiting caused by chemotherapy and radiation, and it is also used off-label to prevent nausea and vomiting during pregnancy. It is also used to prevent nausea and vomiting after surgery.  Having said that, it won't help with nausea caused by motion sickness.   Eligible patient demog

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Ansari, Mohd Razi, Sumer Singh, Majaz Quazi, YAASIR AHMED ANSARI, and Abbas Jameel. "Formulation, Evaluation and Optimization of Orodispersible Tablets of Naproxen Sodium 250 Mg." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 544–49. http://dx.doi.org/10.22270/jddt.v9i4.3197.

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Among the different type of route of administration oral route for drug administration is most common route in which Orodispersible tablet is preferred for the patient which are unconscious, week or for immediate control. The tablet gets dispersed in mouth cavity without water, present study deals with formulation of Naproxen sodium mouth dissolving tablets using super disintegrants. Naproxen sodium is analgesic and NSAID, used for the treatment of pain and inflammation caused by different condition such as osteoarthritis, rheumatoid arthritis and menstrual cramps. However gastric discomfort c

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Bhattacharya, Suhasis, Tanmay Mohanta, Sujit Das, and Rumpa Basak. "Orodispersible Tablet in Treatment of Migraine: Opportunities, Challenges and Recent Advancements." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 149–56. http://dx.doi.org/10.22270/jddt.v11i4.4878.

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The most comfortable and choicely path of drug administration is oral route. Orodispersible tablets bring a revolution among all routes of drug administration as well as oral route of drug administration also. Orodispersible tablets are unit dosage form but it has unique characteristics. It disintegrates in the mouth within a minute for the presence of saliva where the presence of super disintegrates in the preparation. Especially, old and child have no chance to swallow as a result it is very acceptable for them. Migraine is a very well-known irritating condition for adult and female. Migrain

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Shivani, Honmode* Prakash katakam Jadhav S. B. "Comprehensive Review on Fast Mouth Dissolving Film As Novel Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 1 (2024): 124–41. https://doi.org/10.5281/zenodo.10477153.

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Fast mouth dissolving films are solid dosage types that, when placed in the mouth, dissolve or disintegrate over the course of a few seconds. They are not manufactured or palatable. Fast-dissolving films are becoming more popular as an alternative to quick-dissolving tablets in order to reduce patients' concerns about choking and to overcome patients' obstacles. A complex alternative to the traditional pills, capsules, and liquids often associated with prescription and over-the-counter drugs is the quickly disintegrating thin film. Thin film strips are often intended for oral administration, w

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Prachi, Katvate* Dr. Avinash M. Bhagwat Mansi Mane Avantika Bhandugare. "Titrimetric Analysis of Bulk Drug Salicylic Acid Using Hydrotropic Solubilization Method." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2903–6. https://doi.org/10.5281/zenodo.15450243.

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One of the enhancement techniques is hydrotropic solubilization, which uses hydrotropes like sodium citrate, sodium benzoate, urea, etc., to greatly increase solubility. This method has several advantages, such as not requiring organic solvents, chemically modifying hydrophobic drugs, or preparing emulsion systems.This study aims to use hydrotropy to a specific problem: how to make the medicine ibuprofen more soluble in 0.1 M ammonium acetate.Ionic organic salts considered as hydrotropic agent.These days, hydrotropic agents are being utilized to increase the therapeutic efficiency and bioavail

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Ansari, Mohd Razi, Sumer Singh, M. A. Quazi, Yaasir Ahmed Ansari, and Jameel Abbas. "Formulation, Evaluation and Optimization of Orodispersible Tablets of Naproxen sodium by using Superdisintegrant." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 462–68. http://dx.doi.org/10.22270/jddt.v9i4-s.3361.

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Among the different type of route of administration oral route for drug administration is most common route in which Orodispersible tablet is preferred for the patient which are unconscious, week or for immediate control. The tablet gets dispersed in mouth cavity without water, present study deals with formulation of Naproxen sodium mouth dissolving tablets using super disintegrants. Naproxen sodium is analgesic and NSAID, used for the treatment of pain and inflammation caused by different condition such as osteoarthritis, rheumatoid arthritis and menstrual cramps. However gastric discomfort c

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Pande, V. V., A. A. Patel, V. P. Patel, and P. V. Khedkar. "FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF FOSINOPRIL." INDIAN DRUGS 55, no. 12 (2018): 34–40. http://dx.doi.org/10.53879/id.55.12.11461.

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The mouth dissolving film overcomes the shortfalls of conventional quick dispersing/dissolving intraoral tablets. Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.It undergoes extensive hepatic first pass metabolism, with bioavailability being only 36%. In the present investigation, an attempt was made to formulate fast dissolving film of fosinopril sodium by Solvent casting method using various film forming polymers such as HPMC 5cps, HPMC E-3, HPMC E-15 each being varied at three different concentrat

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Rani, Nisha, Dhruv Dev, and D. N. Prasad. "Recent Trends in developments of Superdisintegrants: An Overview." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 163–69. http://dx.doi.org/10.22270/jddt.v12i1.5148.

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Fast dissolving tablets are solid unit dosage forms that dissolve or disintegrate quickly in the mouth without using water. To provide this type of character in a dosage form, different excipients are required. Superdisintegrants are a class of novel agents that have emerged in recent years. Improving drug bioavailability in the pharmaceutical field is a challenge. The inclusion of superdisintegrants in the formulation enhances the formulation's efficacy. The main goal of this review article is to highlight current development in the superdisintegrants. Novel medication delivery techniques hav

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Attar, S. M., S. M. Ghurghure, and Sumit. "Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 2 (2024): 164–70. http://dx.doi.org/10.18231/j.ijpca.2024.023.

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Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to d

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Sharma, Pravin Kumar, Pankaj Kumar Sharma, Gajanan N. Darwhekar, and Birendra Shrivastava. "AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS." International Journal of Drug Regulatory Affairs 6, no. 1 (2018): 1–7. http://dx.doi.org/10.22270/journal.v6i1.220.

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Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of act

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Sharma, Pravin Kumar, Pankaj Kumar Sharma, Gajanan N. Darwhekar, and Birendra Shrivastava. "AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS." International Journal of Drug Regulatory Affairs 6, no. 1 (2018): 1–7. http://dx.doi.org/10.22270/ijdra.v6i1.220.

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Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of act

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Abou-Taleb, Heba A., Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem, and Hamdy Abdelkader. "Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability." Pharmaceutics 14, no. 3 (2022): 517. http://dx.doi.org/10.3390/pharmaceutics14030517.

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Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water

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S, Morris, Badola A, Nainwal N, Ghalwan PK, and Soni P. "Oral Transmucosal Drug Delivery: A Potential Route To Treat Migraine." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 978–83. https://doi.org/10.25258/ijddt.14.4.73.

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Migraine is a complex neurological disease. Migraine headaches described as vascular headaches cause a throbbing and pulsating pain around the head. A migraine attack involves stimulating the sympathetic nerve system, and increased sympathetic activity leads to nausea, vomiting, and diarrhea. Therefore, treatment of migraine requires immediate onset of action of the drug to give fast relief from the pain. Absorption of drugs directly through the oral cavity is one of the efficient ways of treating various diseases. The oral cavity has low enzymatic activity, ease of access for patients to rece

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Karade, Preeti Gajendra, Sonal Jadhav (Mali), and Rohit Ramesh Shah. "Formulation Development of Medicated Chewing Gum by Direct Compression utilizing the SeDeM Diagram Expert System." Journal of Drug Delivery and Therapeutics 14, no. 4 (2024): 59–68. http://dx.doi.org/10.22270/jddt.v14i4.6545.

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The main objective of this study was to prepare and characterize the MCG of Ondan HCl which helps to improve the effectivity of the drug and to investigate the applicability of the SeDeM system for the formulation of MCG. The Ondan HCl was formulated into directly compressed MCG utilizing the SeDeM Diagram Expert System. The MCG was optimized using 32 factorial design. Performance evaluation was carried out by evaluating different parameters. Statistical analysis showed that micromeritic properties were improved after inclusion of appropriate excipient in optimum amount. In-vitro drug release

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Mansoori, Ruksar, Deepti Jain, and Ram Singh Bishnoi. "FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF EGCG (EPIGALLOCATECHIN GALLATE) ENRICHED EXTRACT OF CAMELLIA SINENSIS (GREEN TEA) FOR PERIODONTAL DISEASE." Journal of Advanced Scientific Research 13, no. 08 (2022): 79–86. http://dx.doi.org/10.55218/jasr.202213812.

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The aim of this study was the formulation and evaluation of medicated chewing gum of EGCG (epigallocatechin gallate) enriched extract of camellia sinensis. The extraction of marketed lipton green tea was done by infusion method and antibacterial activities of extract were done against P. gingivalis and S. mutan by well diffusion method. Chewing gum was prepared by softening of gum bases and then mixing with other formulation ingredients and optimization of the formulation by screening of different excipients. Performance evaluation was carried out by evaluating hardness, fracturability, adhesi

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Masih, Daljit, and Rajesh Gupta. "Mouth Dissolving Tablets–A Review." UK Journal of Pharmaceutical Biosciences 1, no. 1 (2013): 18. http://dx.doi.org/10.20510/ukjpb/1/i1/91107.

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Sumit S. Mohite, Amarnath B. Munde, Jai A. Lagad, and Trupti Shaha. "A Review on Mouth Dissolving Tablets." International Journal of Scientific Research in Science and Technology 11, no. 2 (2024): 427–35. http://dx.doi.org/10.32628/ijsrst52411276.

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Traditional dosage forms, such as pills and capsules, are now used to treat conditions like dysphagia, which increases the risk of non-compliance and makes therapy ineffective. Mouth dissolving tablets were created to solve the problems associated with traditional dosage forms. They offer good hardness, dose uniformity, and convenience of administration. For pediatric, geriatric, and travel patients, they are the preferred dose form. Providing the MDTs with enough hardness, integrity, and disintegration speed without the requirement for water was the aim of their development. For fast-dissolvi

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Singh, Gurpreet, Jayesh Dwivedi, Jeyabalan Govindasamy, Naresh Kalra, and Rajesh Sharma. "Formulation of Mouth Dissolving Tablets Using Solid Dispersion Technique: A Review." Indian Journal of Pharmaceutical and Biological Research 6, no. 03 (2018): 66–72. http://dx.doi.org/10.30750/ijpbr.6.3.11.

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Mouth-dissolving tablets are also called as fast disintegrating tablets, melt-in mouth tablets, orodispersible tablets, quick dissolving etc. Mouth dissolving tablets are those when put on tongue disintegrate rapidly thereby releasing the drug, which dissolve or disperses in the saliva. The faster the drug dissolved into solution, quick will be the absorption and onset of clinical effect. Mouth dissolving tablet containing solid dispersion was developed to improve the solubility of drug and stability of solid dispersion. Such tablets are disintegrate and/or dissolve rapidly in the saliva witho

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Bindal, Rishabh, and Arpna Indurkhya. "Formulation and Evaluation of Ketorolac Tromethamine Mouth Dissolving Tablets." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 60–64. http://dx.doi.org/10.22270/jddt.v11i1.4502.

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Due to more versatility and comfort, mouth dissolving tablets are the most advanced type of oral solid dosage forms. Compared to conventional tablets, it increases the effectiveness of APIs by dissolving within a minute in the oral cavity after contact with less saliva, without chewing and without the need for water for administration. Mouth Dissolving Tablets of Ketorolac tromethamine were prepared by direct compression method using various superdisintegrants like crospovidone, Croscarmellose sodium, and Sodium starch glycolate in different concentrations. Prepared tablets were evaluated for

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