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Sornalingam, Krishanthy, Ahmed Javed, Tariq Aslam, et al. "Variability in the ocular phenotype in mucopolysaccharidosis." British Journal of Ophthalmology 103, no. 4 (2018): 504–10. http://dx.doi.org/10.1136/bjophthalmol-2017-311749.
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PurposeMucopolysaccharidoses (MPSs) are a heterogeneous group of lysosomal storage disorders. Ocular complications (such as corneal clouding, retinopathy and optic neuropathy) are common. Notably, there is a paucity of data on the effect of genotype and systemic treatments (enzyme replacement therapy or haematopoietic stem cell transplantation) on the ocular phenotype in MPS. We prospectively studied the ocular features of patients with MPSI (Hurler/Hurler-Scheie/Scheie), MPSIV (Morquio) and MPSVI (Maroteaux-Lamy), to evaluate the effect of different therapeutic interventions and to correlate the findings with genetic and biomarker data.MethodsProspective observational cohort study. Study participants underwent detailed ocular examination including visual acuity; assessment of corneal clouding (Iris camera Corneal Opacification Measure score and Pentacam densitometry) and retinal and optic nerve imaging (optical coherence tomography and wide-field fundus imaging). Data on genotype, biomarkers and delivered therapies (type and length of treatment) were also collected for each patient where available.ResultsOverall, 21 patients with MPSI, 4 patients with MPSIV and 3 patients with MPSVI were recruited. Corneal clouding scores were higher in MPSI compared with MPSIV and MPSVI. Retinopathy was evident in patients with MPSI only. Association was observed between corneal clouding and biomarkers in MPSI, MPSIV and MPSVI. However, no clear association was seen between genotype or treatment type and ocular phenotype.ConclusionsThe ocular phenotype in MPS is variable, with corneal clouding occurring in MPSI, MPSIV and MPSVI, and retinopathy in MPSI only. There was an association between corneal clouding and efficacy of systemic treatment as measured by biomarkers.
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Eremina, A. S., A. Yu Kharin, Yu V. Kargina, and V. Yu Timoshenko. "Stabilization of porous silicon nanoparticles by PEGalization in water." Journal of Physics: Conference Series 2058, no. 1 (2021): 012013. http://dx.doi.org/10.1088/1742-6596/2058/1/012013.
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Abstract Mesoporous silicon (mPSi) nanoparticles (NPs) are stabilized by polyethylene glycol (PEG) chains during mechanical grinding in a ball mill that is used to form mPSi-PEG-NPs. The structure, composition, and properties of the obtained samples are studied by means of the dynamic light scattering, scanning electron microscopy and Fourier-transform infrared spectroscopy. The proposed PEGalization procedure is an effective way of regulating the dissolution of mPSi-NPs in water and it is promising for potential application of mPSi-NPs in drug delivery.
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De Ponti, Giada, Samantha Donsante, Marta Frigeni, et al. "MPSI Manifestations and Treatment Outcome: Skeletal Focus." International Journal of Molecular Sciences 23, no. 19 (2022): 11168. http://dx.doi.org/10.3390/ijms231911168.
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Mucopolysaccharidosis type I (MPSI) (OMIM #252800) is an autosomal recessive disorder caused by pathogenic variants in the IDUA gene encoding for the lysosomal alpha-L-iduronidase enzyme. The deficiency of this enzyme causes systemic accumulation of glycosaminoglycans (GAGs). Although disease manifestations are typically not apparent at birth, they can present early in life, are progressive, and include a wide spectrum of phenotypic findings. Among these, the storage of GAGs within the lysosomes disrupts cell function and metabolism in the cartilage, thus impairing normal bone development and ossification. Skeletal manifestations of MPSI are often refractory to treatment and severely affect patients’ quality of life. This review discusses the pathological and molecular processes leading to impaired endochondral ossification in MPSI patients and the limitations of current therapeutic approaches. Understanding the underlying mechanisms responsible for the skeletal phenotype in MPSI patients is crucial, as it could lead to the development of new therapeutic strategies targeting the skeletal abnormalities of MPSI in the early stages of the disease.
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Şahin Macit, Nazife. "AVRUPA VE ORTA ASYA ÜLKELERİNDE BİT GELİŞMİŞLİK DÜZEYİNİN ENTEGRE MPSI-RAPS YÖNTEMİ İLE ÖLÇÜLMESİ." Kafkas Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi 15, no. 29 (2024): 24–53. http://dx.doi.org/10.36543/kauiibfd.2024.002.
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Bu çalışma, 2023 BİT gelişim endeksi raporunda yer alan 10 göstergeye dayanarak Avrupa ve Orta Asya için seçilmiş 14 ülkenin Bilgi ve İletişim Teknolojileri (BİT) gelişmişlik düzeylerini MPSI- RAPS entegre yöntemiyle objektif bir şekilde ele alarak gelecekteki politika ve stratejiler için temel bilgiler sunmak amacıyla gerçekleştirilmiştir. Kriter olarak dikkate alınan göstergelerin ağırlık değerleri MPSI yöntemi ile tespit edilmiş; ülkelerin kriterlere göre gelişmişlik düzeylerinin belirlenip karşılaştırılması ise RAPS yöntemi yapılmıştır. Yapılan analiz sonucunda en önemli kriterin sabit geniş bant internet sepet fiyatı (% GSMH/k.) olduğu; en önemsiz kriterin ise en az 3G mobil ağının kapsadığı nüfus (%) olduğu ortaya çıkmıştır. Avusturya BİT gelişmişlik düzeyinde en üst sırayı alırken, Azerbaycan en düşük düzeyde olan ülke olarak belirlenmiştir. Ayrıca, MPSI-RAPS entegre yöntemi analiziyle elde edilen sıralamalar ile BİT (Bilgi Teknolojileri) gelişmişlik indeksi raporundaki sıralamalar arasında anlamlı ve güçlü bir pozitif ilişki olduğu, Spearman Rho Korelasyon testi sonucunda ortaya çıkmıştır. Bu bulgu, MPSI-RAPS entegre yönteminin ülkelerin BİT gelişmişlik düzeylerini değerlendirmede kullanılabileceğini göstermiştir.
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Woloszynek, Josh C., Trey Coleman, Clay F. Semenkovich, and Mark S. Sands. "Lysosomal Dysfunction Results in Altered Energy Balance." Journal of Biological Chemistry 282, no. 49 (2007): 35765–71. http://dx.doi.org/10.1074/jbc.m705124200.
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The mucopolysaccharidosis (MPS) type VII mouse was originally described as the adipose storage deficiency mouse because of its extreme lean phenotype of unknown etiology. Here, we show that adipose storage deficiency and lower leptin levels are common to five different lysosomal storage diseases (LSDs): MPSI, MPSIIIB, MPSVII, Niemann-Pick type A/B, and infantile neuronal ceroid lipofuscinosis. Elevated circulating pro-inflammatory proteins (VCAM1 and MCP1) were found in multiple LSDs. Multiple anti-inflammatory strategies (dexamethasone, MCP1 deficiency, M3 expression) failed to alter adiposity in LSD animals. All of the models had normal or greater caloric intake and lower to normal metabolic rate, fasting plasma glucose, non-esterified fatty acids, cholesterol, and triglycerides. Triglycerides were lower in the livers of MPSI mice, and the trend was lower in the muscle. Lipid absorption and processing in MPSI mice were indistinguishable from those in normal mice following oral gavage of olive oil. The increased lean mass of MPSI and MPSIIIB mice suggests a shift in adipose triglycerides to lysosomal storage. In agreement, MPSI livers had a similar total caloric content but reduced caloric density, indicating a shift in energy from lipids to proteins/carbohydrates (lysosomal storage). Enzyme replacement therapy normalized the caloric density within 48 h without reducing total caloric content. This was due to an increase in lipids. Recycling of stored material is likely reduced or nonexistent. Therefore, to maintain homeostasis, energy is likely diverted to synthesis at the expense of typical energy storage depots. Thus, these diseases will serve as important tools in studying the role of lysosome function in metabolism and obesity.
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Lahr, Ashley, Lee Williams, Nadene Henderson, Georgianne Arnold, and Damara Ortiz. "Overview of Newborn Screening of Lysosomal Storage Diseases for Pediatric Care Providers." OBM Genetics 07, no. 03 (2023): 1–12. http://dx.doi.org/10.21926/obm.genet.2303194.
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Lysosomal storage disorders (LSD) are caused by enzymatic failure to degrade specific cellular byproducts of metabolism within the lysosome. They have a wide range of presentations involving multiple body systems and can manifest from infancy through adulthood. As treatments have become available for many of these disorders, newborn screening has been adapted for early identification and pre-symptomatic treatment. This article will review some of the LSD that are now being added to newborn screening panels, including globoid cell leukodystrophy (Krabbe), Gaucher disease, Fabry disease, Mucopolysaccharidosis Type I (Hurler; MPSI), Mucopolysaccharidosis Type II (Hunter; MPSII), Acid Sphingomyelinase deficiency (ASMD), and Pompe disease.
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Abdullahi, M. "Pebble Morphometric Studies of Part of Bida Formation, Northern Bida Basin, North Central Nigeria." Pebble Morphometric Studies of Part of Bida Formation, Northern Bida Basin, North Central Nigeria 6, no. 2 (2020): 25–31. https://doi.org/10.31695/IJASRE.2020.33688.
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<em>The Bida formation exposed in Doko locality, Bida town appeared Massive, poorly sorted with localized sedimentary structures. The formation shows three lithofacies: mf, ssf and sf respectively. The formation grades into more matured upward, the pebbles are found within the sf unit as lenses and as scattered pebbles. Vernier caliper was used to measure the Longest, intermediate and shortest axes that are mutually perpendicular for each pebble. These values were used to compute different morphometric parameters as a single variable including MPSI, OPI, FR, ER, R and CF. These parameters were also used as dependent variables in bivariate plots to characterize the depositional process. The average values of MPSI, OPI, FR, ER, and CF are: 0.64, 3.01,0.41, 0.63, 44.5 and 40.73 respectively. The ternary plot of the ratios of the three-axis showed that most samples fall within Bladed(B) field while some other few on Elongate(E) Field, the plot of MPSI versus OPI, FI versus MPSI and R versus ER. Both independent and dependent parameters showed that the Bida formation was deposited by both river and beach processes. Its therefore deduced that the fluvial deposits were later modified by marine activities, possibly during the transgression period. </em>
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Sunardi, Bambang, Sulastri, Dwikorita Karnawati, et al. "Acceleration Response Spectra for M 7.4 Donggala Earthquake and Comparison with Design Spectra." Journal of Sustainable Engineering: Proceedings Series 1, no. 1 (2019): 20–26. http://dx.doi.org/10.35793/joseps.v1i1.3.
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A 7.4 magnitude earthquake have strucked Donggala on September 28th 2018, followed by tsunami and liquefaction which hit Palu, Central Sulawesi, a few minutes later. This event had resulted in damage to buildings, and caused more than 2,000 people were killed and injured. Indonesia already have a building code in form of SNI 1726:2002 which had been updated to SNI 1726:2012. This paper analyses the hazard level caused by the 2018 Donggala earthquake compared to the existing design spectra, as mentioned in SNI 1726:2002 and SNI 1726:2012. A simple analysis was carried out by comparing Donggala earthquake’s acceleration response spectra with the existing design spectra, at the MPSI accelerograph station. The site class at MPSI station is hard soil (SC). The seismic hazard in Palu and Donggala refers to SNI 1726:2002 is included in the earthquake area 4. The maximum earthquake response factor for earthquake area 4 is about 0.6 for hard soil type (SC). The MPSI station recorded peak ground acceleration of Donggala earthquake around 0.14 g. The acceleration response spectra recorded at the MPSI station showed a peak value of around 0.71 g for the N component. This value is actually still below the design spectra referring to SNI 1726:2012, which the peak value is 0.88 g for SC, but, it exceeded the design spectra of SNI 1726:2002.
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Ruan, Ou, Changwang Yan, Jing Zhou, and Chaohao Ai. "A Practical Multiparty Private Set Intersection Protocol Based on Bloom Filters for Unbalanced Scenarios." Applied Sciences 13, no. 24 (2023): 13215. http://dx.doi.org/10.3390/app132413215.
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Multiparty Private Set Intersection (MPSI) is dedicated to finding the intersection of datasets of multiple participants without disclosing any other information. Although many MPSI protocols have been presented, there are still some important practical scenarios that require in-depth consideration such as an unbalanced scenario, where the server’s dataset is much larger than the clients’ datasets, and in cases where the number of participants is large. This paper proposes a practical MPSI protocol for unbalanced scenarios. The protocol uses the Bloom filter, an efficient data structure, and the ElGamal encryption algorithm to reduce the computation of clients and the server; adopts randomization technology to solve the encryption problem of the 0s in the Bloom filter; and introduces the idea of the Shamir threshold secret-sharing scheme to adapt to multiple environments. A formal security proof and three detailed experiments are given. The results of the experiments showed that the new protocol is very suitable for unbalanced scenarios with a large number of participants, and it has a significant improvement in efficiency compared with the typical related protocol (TIFS 2022).
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Pei, Song, Xingyao Yin, and Kun Li. "Full-time domain matching pursuit and empirical mode decomposition based sparse fixed-point seismic inversion." Journal of Geophysics and Engineering 19, no. 2 (2022): 255–68. http://dx.doi.org/10.1093/jge/gxac014.
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Abstract Sparse seismic inversion is wildly utilized for reservoir prediction and resolution improvement. Matching pursuit (MP) is an effective algorithm for solving L0-norm and obtaining sparse inversion results. Sparse seismic inversion based on MP (MPSI) can estimate the sparse parameters of subsurface from observations by controlling the iterations and threshold. However, the low convergence and stability limit the application of MPSI. To accelerate the convergence of MP, the full-time domain matching pursuit (FTMP) algorithm is first proposed. The seismic inversion based on FTMP can realize the multi-point inversion simultaneously instead of searching the inversion results one by one, which is the process of MPSI. Also, the prior model constraint is then involved in the objective function to improve the stability and the layer-boundary fidelity of the inversion results. Furthermore, the empirical mode decomposition (EMD) algorithm is introduced into inversion framework to recover the features of the seismic signal from the noisy seismic signal. The fixed-point (FP) algorithm is adopted to solve the objective function in this study. The optimal inversion results can be estimated after finite iterations by the FP algorithm. Combining the FTMP sparse seismic inversion framework, prior model constraint, EMD and FP algorithms, a complete sparse seismic inversion method named the full-time domain matching pursuit-based sparse fixed-point seismic inversion is ultimately proposed. The synthetic and field examples are utilized to demonstrate the stability and practicality of this approach. Compared with MPSI, the inversion results of the proposed method have higher resolution and fidelity of the layer-boundary.
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Hudson, Walter W., and Steven L. McMurtry. "Comprehensive Assessment in Social Work Practice: The Multi-Problem Screening Inventory." Research on Social Work Practice 7, no. 1 (1997): 79–98. http://dx.doi.org/10.1177/104973159700700105.
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Findings are reported from an initial evaluation of a new multidimensional assessment tool, the Multi-Problem Screening Inventory (MPSI). The inventory gathers information on 27 different areas of personal and social functioning and is designed for use by human service practitioners in a variety of settings. Basic guidelines for using the instrument are detailed, with emphasis given to the preparation and interpretation of graphic profiles for rapid but comprehensive client assessments. Reliabilities and validities obtained for each of the subscales are then reviewed, along with suggestions for further development and use of the MPSI in clinical trials and research applications.
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Ersoy, Nazlı, Mehmet Özçalıcı, and Do Duc Trung. "A Hybrid MCDM Approach for SDGs Assessment of EU Countries." Spectrum of Decision Making and Applications 3, no. 1 (2025): 164–86. https://doi.org/10.31181/sdmap31202637.
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This study assesses the progress of EU countries in achieving the Sustainable Development Goals (SDGs) using Multi-Criteria Decision-Making (MCDM) methods. The evaluation covers 27 countries and is based on 15 indicators for the 2019–2021 period. The MPSI-RAPS model was employed to determine indicator weights and rank the alternatives. To ensure robustness, a comprehensive sensitivity analysis was conducted across 16 scenarios. The final rankings from the MPSI-RAPS model identified Sweden, the Netherlands, and Germany as the top-performing countries in sustainable development progress. Notably, rankings varied significantly across scenarios, underscoring the impact of methodological choices on outcomes.
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Vashakmadze, Nato, Natalya Zhurkova, Ekaterina Zakharova, Marina Babaikina, Anastasia Rykunova, and Leyla Namazova-Baranova. "Mild forms of mucopolysaccharidosis type I (MPSI)." Molecular Genetics and Metabolism 132, no. 2 (2021): S108. http://dx.doi.org/10.1016/j.ymgme.2020.12.265.
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Ames, Elizabeth G., Rachel Fisher, Mary Kleyn, and Ayesha Ahmad. "Current Practices for U.S. Newborn Screening of Pompe Disease and MPSI." International Journal of Neonatal Screening 6, no. 3 (2020): 72. http://dx.doi.org/10.3390/ijns6030072.
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Two lysosomal storage disorders (LSDs), Pompe disease and Mucopolysaccharidosis type I (MPSI) were added to the Recommended Uniform Screening Panel (RUSP) for newborn screening (NBS) in 2015 and 2016, respectively. These conditions are being screened with variable practice in terms of primary and reflex analytes (either biochemical or molecular testing) as well as collection of short- and long-term follow-up elements. The goal of this study is to evaluate practices of state health departments in regards to screening methods and follow-up data collected. We conducted online surveys and phone questionnaires to determine each U.S. state’s practices for screening and follow-up of positive newborn screens. We report the first snapshot of practices for NBS for the LSDs included on the RUSP. All 50 U.S. states responded to our survey. The majority of U.S. states are not currently screening for Pompe disease and MPSI as of March 2020, but this number will increase to 38 states in the coming 1–3 years based on survey results. Our survey identifies data elements used by state health departments for short-and long-term follow-up that could serve as the basis of common elements for larger, public health-based analyses of the benefits and efficacy of screening for Pompe disease and MPSI.
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Kassisse, Elias, Joanna Jimenez, Nelly Mayo, and Jorge Kassisse Limongi. "Sulfato de magnesio vs aminofilina como segunda línea de manejo en niños con asma aguda severa. Ensayo clínico aleatorizado." Andes Pediatrica 92, no. 3 (2021): 367. http://dx.doi.org/10.32641/andespediatr.v92i3.2969.
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Los medicamentos de segunda línea en el asma aguda generalmente son de administración endovenosa: salbutamol, sulfato de magnesio y aminofilina.Objetivo: comparar la eficacia y seguridad del uso de sulfato de magnesio vs aminofilina en niños que no respondieron al tratamiento inicial.Pacientes y Método: Ensayo clínico aleatorizado. Los niños que no mejoraron el Score de Índice Pulmonar Modificado (mPSI) fueron aleatorizados a recibir sulfato de magnesio (50 mg/Kg/dosis única) o aminofilina (5 mg/Kg/dosis seguida de infusión continua a 1 mg/kg/hora por 3 h). Resultados primarios: cambios en el mPSI y la saturación de oxígeno; resultados secundarios: tasa de hospitalización, necesidad de traslado a unidad de cuidados intensivos, uso de una tercera intervención y efectos adversos.Resultados: Se estudiaron 131 pacientes (66 pacientes en el grupo de la aminofilina y 65 MgSO4). La edad promedio fue de 5 ± 2,3 años, los parámetros demográficos y clínicos no difirieron entre los grupos. En el grupo que recibió sulfato el mPSI y la saturación de oxigeno se modificaron favorablemente de forma significativa desde 13,1 ± 1,3 hasta 4,9 ± 2,5 (p < 0,001) y de 3,3 ± 2,5; (p 0,021), respectivamente. De igual forma en el grupo que recibió el sulfato se redujo el riesgo de admisión (RR 0,68 95% IC [0,56; 0,82]) y el de fallas secundaria (0,16 95% IC 95% [0,07; 0,38]). Solo se registró un evento adverso (taquicardia).Conclusión: La administración de una dosis única de sulfato de magnesio demostró ser más eficaz y segura que el uso de la aminofilina como agente de segunda línea.
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Zheng, Yun, Sigfrid D. Soli, Kai Wang, et al. "Development of the Mandarin pediatric speech intelligibility (MPSI) test." International Journal of Audiology 48, no. 10 (2009): 718–28. http://dx.doi.org/10.1080/14992020902902658.
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Nugent, William R. "A Psychometric Study of the MPSI Suicidal Thoughts Subscale." Stress, Trauma, and Crisis 9, no. 1 (2006): 1–15. http://dx.doi.org/10.1080/15434610500506209.
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Belaoui, Meymoun, Malika Berouaken, Chafiaa Yaddaden, et al. "Preparation of high specific surface mPSi/Al2O3/ZnO microcapacitors." Nano-Structures & Nano-Objects 34 (April 2023): 100972. http://dx.doi.org/10.1016/j.nanoso.2023.100972.
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Adams, W. W., and S. J. Krause. "Morphology of High-Performance Rigid-Rod Polymer Fibers and Molecular Composites." Proceedings, annual meeting, Electron Microscopy Society of America 47 (August 6, 1989): 338–39. http://dx.doi.org/10.1017/s042482010015366x.
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Rigid-rod polymers such as PBO, poly(paraphenylene benzobisoxazole), Figure 1a, are now in commercial development for use as high-performance fibers and for reinforcement at the molecular level in molecular composites. Spinning of liquid crystalline polyphosphoric acid solutions of PBO, followed by washing, drying, and tension heat treatment produces fibers which have the following properties: density of 1.59 g/cm3; tensile strength of 820 kpsi; tensile modulus of 52 Mpsi; compressive strength of 50 kpsi; they are electrically insulating; they do not absorb moisture; and they are insensitive to radiation, including ultraviolet. Since the chain modulus of PBO is estimated to be 730 GPa, the high stiffness also affords the opportunity to reinforce a flexible coil polymer at the molecular level, in analogy to a chopped fiber reinforced composite. The objectives of the molecular composite concept are to eliminate the thermal expansion coefficient mismatch between the fiber and the matrix, as occurs in conventional composites, to eliminate the interface between the fiber and the matrix, and, hopefully, to obtain synergistic effects from the exceptional stiffness of the rigid-rod molecule. These expectations have been confirmed in the case of blending rigid-rod PBZT, poly(paraphenylene benzobisthiazole), Figure 1b, with stiff-chain ABPBI, poly 2,5(6) benzimidazole, Fig. 1c A film with 30% PBZT/70% ABPBI had tensile strength 190 kpsi and tensile modulus of 13 Mpsi when solution spun from a 3% methane sulfonic acid solution into a film. The modulus, as predicted by rule of mixtures, for a film with this composition and with planar isotropic orientation, should be 16 Mpsi. The experimental value is 80% of the theoretical value indicating that the concept of a molecular composite is valid.
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Kara, Karahan, Hamide Özyürek, and Galip Cihan Yalçın. "Evaluating ESG-Based Sustainability in Software Companies: A Performance Analysis Using MPSI-OPLO-POCOD Framework." Computer and Decision Making: An International Journal 2 (April 13, 2025): 570–98. https://doi.org/10.59543/comdem.v2i.13855.
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In today's world, companies are restructuring their operations with a focus on Environmental, Social, and Governance (ESG) criteria to build a sustainable economy. In this context, efforts to meet the requirements of sustainability are increasingly on the rise. By establishing a sustainable financial performance structure, companies are enhancing their efforts to gain both short-term and long-term competitive advantages. This research explores ESG-based sustainable performance analysis, supported by practical applications. Additionally, a model based on Multi-Criteria Decision-Making (MCDM) is proposed, and an approach for sustainable performance analysis is implemented in this study. The Modified Preference Selection Index-Opportunity Losses‐Based Polar Coordinate Distance (MPSI-OPLO-POCOD) method is used for performance analysis in this research. In this method, the MPSI approach applies objective criteria weighting to determine the importance of different factors, while the OPLO-POCOD method is used to derive the performance values and rankings of companies. The performance levels for 17 software companies listed in the S&P 500 index for the years 2021, 2020, 2019, and 2018 are determined using the MPSI-OPLO-POCOD method. Four applications are conducted within this scope. The decision model for the research includes ESG scores and financial ratios as the criteria. In the application results, the most important criteria for the years 2021, 2020, 2019, and 2018 are identified as Return on Equity (ROE), ROE, Tobin Q Ratio, and Earnings Before Interest, Taxes, Depreciation, and Amortization (EBITDA), respectively. In the performance rankings of software companies, the companies with the highest performance levels for the years 2021, 2020, 2019, and 2018 are identified as PTC Inc (PTC.OQ), Autodesk Inc (ADSK.OQ), Cadence Design Systems Inc (CDNS.OQ), and Autodesk Inc (ADSK.OQ), respectively. Furthermore, the research includes assessments of performance changes before and after the Covid-19 period. The application results are also validated through sensitivity analyses.
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Zhang, Jing, Li Yang, Yongli Tang, Minglu Jin, and Shujing Wang. "A Novel Edge Cache-Based Private Set Intersection Protocol via Lightweight Oblivious PRF." Entropy 25, no. 9 (2023): 1347. http://dx.doi.org/10.3390/e25091347.
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With the rapid development of edge computing and the Internet of Things, the problem of information resource sharing can be effectively solved through multi-party collaboration, but the risk of data leakage is also increasing. To address the above issues, we propose an efficient multi-party private set intersection (MPSI) protocol via a multi-point oblivious pseudorandom function (OPRF). Then, we apply it to work on a specific commercial application: edge caching. The proposed MPSI uses oblivious transfer (OT) together with a probe-and-XOR of strings (PaXoS) as the main building blocks. It not only provides one-sided malicious security, but also achieves a better balance between communication and computational overhead. From the communication pattern perspective, the client only needs to perform OT with the leader and send a data structure PaXoS to the designated party, making the protocol extremely efficient. Moreover, in the setting of edge caching, many parties hold a set of items containing an identity and its associated value. All parties can identify a set of the most frequently accessed common items without revealing the underlying data.
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A Ojong, Romeo, Samuel I Ugar, Peter O Odong, et al. "Pebble morphometry and sieve analysis: tools in determining the depositional environments of sediments in oron and environs." Global Journal of Geological Sciences 21, no. 2 (2023): 201–13. http://dx.doi.org/10.4314/gjgs.v21i2.4.
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Pebble morphometry and grain size analysis were carried out in parts of Benin Formation exposed along Oron and environs to determine the depositional environment of the sediments. Quartz pebbles (900 pebbles) collected from 60 different locations around stream channels and quarries were subjected to axial measurement of long (L), short (S) and intermediate (I) axis. Fifteen (15) sediments were further subjected to sieve analysis. Results from morphometric studies shows that the pebbles are dominantly compact-bladed (CB) and elongate (E) with mean values for flatness ratio (FR), elongation ratio (ER), maximum projection sphericity index (MPSI), oblate-prolate index (OPI) and braided ratio (BR) as 0.48, 0.61, 0.67, 3.54 and 0.63 respectively with mean roundness value of 32%. Sieve analysis revealed that the sediments are dominantly medium-grained, well sorted, skewed to near symmetrical and leptokurtic to mesokurtic. Bivariate Plots of roundness versus elongation ratio, sphericity versus OP index, FI versus MPSI, and skewness versus sorting indicates deposition of the sediments predominantly in the fluvial environment. Thus, this study showed that the sediments in Benin Formation were deposited by fluvial depositional processes.
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Gligorić, Miloš, Zoran Gligorić, Suzana Lutovac, Milanka Negovanović, and Zlatko Langović. "Novel Hybrid MPSI–MARA Decision-Making Model for Support System Selection in an Underground Mine." Systems 10, no. 6 (2022): 248. http://dx.doi.org/10.3390/systems10060248.
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An underground mine is a very complex production system within the mining industry. Building up the underground mine development system is closely related to the installation of support needed to provide the stability of mine openings. The selection of the type of support system is recognized as a very hard problem and multi-criteria decision making can be a very useful tool to solve it. In this paper we developed a methodology that helps mining engineers to select the appropriate support system with respect to geological conditions and technological requirements. Accordingly, we present a novel hybrid model that integrates the two following decision-making components. First, this study suggests a new approach for calculating the weights of criteria in an objective way named the Modified Preference Selection Index (MPSI) method. Second, the Magnitude of the Area for the Ranking of Alternatives (MARA) method is proposed as a novel multi-criteria decision-making technique for establishing the final rank of alternatives. The model is tested on a hypothetical example. Comparative analysis confirms that the new proposed MPSI–MARA model is a very useful and effective tool for solving different MCDM problems.
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Biswas, Sanjib, Biplab Biswas, and Kaushik Mitra. "A Novel Group Decision Making Model to Compare Online Shopping Platforms." Spectrum of Decision Making and Applications 2, no. 1 (2024): 1–27. http://dx.doi.org/10.31181/sdmap2120259.
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Over the years, E-commerce industry has been witnessing a phenomenal growth, thanks to rapid technological advancement in Industry 4.0. There has been a standout surge in the use of various online shopping platforms (OSP) for daily use. The recent pandemic has accelerated the growth trajectory and made a transformational change in the digital commerce landscape. As a result, there has been a proliferation of OSPs in the competitive domain. It is therefore pertinent to address the questions: How do the customers select their favorite OSP? To what extent the OSPs differ based on consumers’ preferences? The present work addresses these questions by proposing a novel group decision making framework. The ongoing study provides several innovative extensions of multi criteria decision making models like Borda count, criteria importance assessment (CIMAS), modified preference selection index (MPSI), and root assessment method (RAM). In this paper, the researchers provide a novel use of the Borda count method, integrated with CIMAS for determining criteria weights utilizing ranking of the criteria. Further, a novel extension of MPSI and RAM has been made with multiple normalizations. In this paper, the authors demonstrate a rare combination of vector and non-linear normalization using the Heron mean. The present paper derives the final criteria weights by combining Borda count, CIMAS and multi-normalization based MPSI (MNMPSI) using Bayesian logic. The criteria are selected based on Uses and Gratification theory (UGT). The findings reveal that interactive app interface and features (C16), user-friendly interface and search (C13), convenience in shopping (C14), product availability and variety (C12) and discounts and offers (C8) exert significant influence in selecting the OSP. Further, it is observed that Flipkart (A2) and Amazon (A1) are the top performers in the eyes of the users. The stability and reliability of the proposed methodology are examined by conducting a sensitivity analysis and comparing with several other models. The robustness of the proposed methodology and practical relevance of the findings of the present work shall provide notable impetus to the analysts and strategic decision-makers.
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Rodríguez-Arteche, Iñigo, and M. Mercedes Martínez-Aznar. "Chemistry open-ended problem solving during initial secondary education teacher training." International Journal of Learning and Teaching 8, no. 3 (2016): 174. http://dx.doi.org/10.18844/ijlt.v8i3.895.
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We present a case study of the work with the Methodology of Problem-Solving as an Investigation (MPSI) in the context of the Spanish Master’s in Secondary Education. Here, future physics and chemistry secondary teachers had to solve some sequences of school open-ended problems, in order to promote reflection on its characteristics and favour its later use. The objectives of this research consist of describing how the problem “What might happen when a substance is heated up?” was introduced, and analysing preservice teachers’ achievement levels in the competence dimensions of the MPSI. In addition, the article justifies the suitability of the abovementioned problem to work on most of the curricular requirements about physical and chemical changes in a single problem. The results from the future teachers’ written reports can be considered as positive, and appear to be best for the “formulation of hypotheses” and worst for the “design of resolution strategies”. Moreover, these results do not seem to very much depend on the preservice teachers’ previous studies. Finally, we call for providing more inquiry-based learning opportunities to future teachers, in order to promote improvement in these scientific competencies and favour a later inclusion of the Inquiry-Based Science Education at school levels.
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Dreyfus, JC. "La maladie de Hurler (mucopolysaccharidose type I MPSI). Mutations et polymorphismes." médecine/sciences 9, no. 11 (1993): 1289. http://dx.doi.org/10.4267/10608/2855.
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Boado, Ruben J. "IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport." Pharmaceutics 14, no. 7 (2022): 1476. http://dx.doi.org/10.3390/pharmaceutics14071476.
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The treatment of neurological disorders with large-molecule biotherapeutics requires that the therapeutic drug be transported across the blood–brain barrier (BBB). However, recombinant biotherapeutics, such as neurotrophins, enzymes, decoy receptors, and monoclonal antibodies (MAb), do not cross the BBB. These biotherapeutics can be re-engineered as brain-penetrating bifunctional IgG fusion proteins. These recombinant proteins comprise two domains, the transport domain and the therapeutic domain, respectively. The transport domain is an MAb that acts as a molecular Trojan horse by targeting a BBB-specific endogenous receptor that induces receptor-mediated transcytosis into the brain, such as the human insulin receptor (HIR) or the transferrin receptor (TfR). The therapeutic domain of the IgG fusion protein exerts its pharmacological effect in the brain once across the BBB. A generation of bifunctional IgG fusion proteins has been engineered using genetically engineered MAbs directed to either the BBB HIR or TfR as the transport domain. These IgG fusion proteins were validated in animal models of lysosomal storage disorders; acute brain conditions, such as stroke; or chronic neurodegeneration, such as Parkinson’s disease and Alzheimer’s disease. Human phase I–III clinical trials were also completed for Hurler MPSI and Hunter MPSII using brain-penetrating IgG-iduronidase and -iduronate-2-sulfatase fusion protein, respectively.
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Abude, Francis Mawuli, Jones Odei-Mensah, and Eric Schaling. "Developing Artificial Intelligence-Powered Monetary Policy Communication Indicators for Macroeconomic Inquiries in Ghana." Communicare: Journal for Communication Studies in Africa 43, no. 1 (2024): 14–35. http://dx.doi.org/10.36615/jcsa.v43i1.2779.
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Central bank communication is a valuable source of information designed to shape the expectations of economic agents within and outside an economy. In particular, the content of Monetary Policy Committees’ press releases and statements reflect the central banks’ view of current and future macroeconomic developments, making them useful for creating high-frequency indicators as alternatives to traditional but slower-to-publish macroeconomic indicators. In this study, Artificial Intelligence (AI)-powered text-mining techniques were employed to create monetary policy communication-based indicators, namely the Monetary Policy Readability Index (MPRI), the Monetary Policy Sentiment Index (MPSI), and the Monetary Policy Uncertainty Index (MPUI), using press releases from the Bank of Ghana's monetary policy committee spanning January 2003 to December 2022. The findings suggest that while readability and sentiments generally declined over the sample period, uncertainty increased, indicating persistent macroeconomic imbalances and vulnerabilities in the domestic economy. The newly developed time series-based indicators demonstrate Granger causal relationships with key macroeconomic variables, affirming their relevance to the central bank, the Ministry of Finance, researchers, investors, and development partners. Notably, the indicators can serve as an early warning system for monitoring and predicting the country's macroeconomic risks, forecasting lagging indicators, assessing the effectiveness of the Bank’s monetary policy communication, and addressing monetary policy inquiries.
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Ahn, Chiyoung, Mikyoeng Kim, Soojin Lee, et al. "Molecular Analysis of mps Operon Involved in Monapterin Syntliesis in Escherichia Coli." Pteridines 17, no. 1 (2006): 16–19. http://dx.doi.org/10.1515/pteridines.2006.17.1.16.
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Abstract Two genes, mpsA and mpsB, constitute an operon in the synthesis of monapterin in E. coli. Expression of mpsA, the structural gene for dihydroneopterin triphosphate 2'-epimerase, from its native promoter, required mpsB. Cotransfonnation of mpsB excludes the possibility that the MpsB is a transactivator protein for mpsA expression.
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Кожанов, А. И., and О. С. Зикиров. "BOUNDARY VALUE PROBLEMS FOR TWICE DEGENERATE DIFFERENTIAL EQUATIONS WITH MULTIPLE CHARACTERISTICS." Журнал «Математические заметки СВФУ», no. 4(100) (December 1, 2018): 35–46. http://dx.doi.org/10.25587/svfu.2018.100.20552.
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Работа посвящена исследованию разрешимости краевых задач для вырождающихся дифференциальных уравнений вида $$varphi(t)u_t-(-1)^mpsi(t)D^{2m+1}_{x}u+c(x,t)u=f(x,t)$$ ($D^k_x=frac{partial^k}{partialx^k,,mgeq 1}$ целое, $xin(0,1),, tin(0,T),,0<T<+infty,$ называемых уравнениями с кратными характеристиками. В этих уравнениях функция $varphi(t)$ может менять знак на отрезке $[0, T]$ произвольным образом, функция $psi(t)$ предполагается неотрицательной. Для изучаемых уравнений предлагаются постановки краевых задач, существенным образом определяющиеся числами $varphi(0)$ и $varphi(T)$, и для предложенных задач доказываются теоремы существования и единственности регулярных (имеющих все обобщенные по С. Л. Соболеву производные, входящие в уравнение) решений. We study the solvability of boundary value problems for degenerate differential equations of the form $$varphi(t)u_t-(-1)^mpsi(t)D^{2m+1}_{x}u+c(x,t)u=f(x,t)$$ ($D^k_x=frac{partial^k}{partialx^k,,mgeq 1}$ is an integer, $xin(0,1),, tin(0,T),,0<T<+infty,$ called equations with multiple characteristics. In these equations, the function $varphi(t)$ can change the sign on the interval $[0, T]$ arbitrarily, while the function $psi(t)$ is assumed nonnegative. For the equations under consideration, we propose the formulation of boundary value problems which are essentially determined by numbers $varphi(0)$ and $psi(T)$. Existence and uniqueness theorems are proved for the regular solutions that have all Sobolev generalized derivatives entering into the equation.
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Ishak, Ruhaizad, Azah Mohamed, Ahmed N. Abdalla, and Mohd Zamri Che Wanik. "Optimal placement and sizing of distributed generators based on a novel MPSI index." International Journal of Electrical Power & Energy Systems 60 (September 2014): 389–98. http://dx.doi.org/10.1016/j.ijepes.2014.03.044.
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Fan, Jinbo, Hui Jin, Bailey A. Koch, and Hong-Guo Yu. "Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast." Life Science Alliance 3, no. 12 (2020): e202000824. http://dx.doi.org/10.26508/lsa.202000824.
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The linker of the nucleoskeleton and cytoskeleton (LINC) complex is composed of two transmembrane proteins: the KASH domain protein localized to the outer nuclear membrane and the SUN domain protein to the inner nuclear membrane. In budding yeast, the sole SUN domain protein, Mps3, is thought to pair with either Csm4 or Mps2, two KASH-like proteins, to form two separate LINC complexes. Here, we show that Mps2 mediates the interaction between Csm4 and Mps3 to form a heterotrimeric telomere-associated LINC (t-LINC) complex in budding yeast meiosis. Mps2 binds to Csm4 and Mps3, and all three are localized to the telomere. Telomeric localization of Csm4 depends on both Mps2 and Mps3; in contrast, Mps2’s localization depends on Mps3 but not Csm4. Mps2-mediated t-LINC complex regulates telomere movement and meiotic recombination. By ectopically expressing CSM4 in vegetative yeast cells, we reconstitute the heterotrimeric t-LINC complex and demonstrate its ability to tether telomeres. Our findings therefore reveal the heterotrimeric composition of the t-LINC complex in budding yeast and have implications for understanding variant LINC complex formation.
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-, Riswan. "EVALUASI MODUL KULIAH DALAM PROSES PERKULIAH DI STMIK NURDIN HAMZAH." JURNAL AKADEMIKA 11, no. 1 (2018): 37–40. https://doi.org/10.53564/akademika.v11i1.301.
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This research was conducted to evaluate student lecture modules made by lecturers. It is hoped that with this module the general objectives and specific instructional objectives of the course will be achieved well. The preparation of the lecture module is done by the lecturers themselves. In general, the module material is adjusted to the weight of the course. This module is a guide for students in the lecture process for one semester. Lecturers explain the material in the form of power points sourced from the module. To determine the quality of the module, a study was conducted on one of the Information Systems Project Management (MPSI) modules which researchers fostered in the fifth semester of the information system study program. Module assessment data is obtained through questionnaire online form with seven variables and several indicators. The evaluation results of the MPSI module on content accuracy variables, with valid indicators that answered "Yes", 15 people, "No", 7 People, harmony, answered "Yes", 22 people, and late, answered "Yes", 21 people, "No", 1 person. Variable accuracy of content coverage, with indicators of freedom in accordance with instructional objectives in general answered "Yes" 22 people, depth indicators according to instructional answers "Yes", 21 people, "No", 1 person, indicator of integrity concept 21 people answered "Yes" , 1 person "No". Variables Digestion, with logical indicators, answer "Yes", 20 people, 2 people "No", coherent indicators, answer "Yes", 12, "No", 10 people, indicators of sufficient control and illustrations, answer "Yes", 14 people, and "No" 8 people, format indicators are consistent, answer "Yes", 20 people, "No", 2 people. Other variables and indicators are seen in the results and discussion.
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Khimji, I., C. Lepage, L. Zalesky, et al. "Combined home enzyme replacement therapy and unrelated cord blood transplant for Hurler’s syndrome (MPSI)." Biology of Blood and Marrow Transplantation 12, no. 2 (2006): 129. http://dx.doi.org/10.1016/j.bbmt.2005.11.395.
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Zaldivar, Rafael J., Gerald S. Rellick, and J. M. Yang. "Fiber strength utilization in carbon/carbon composites." Journal of Materials Research 8, no. 3 (1993): 501–11. http://dx.doi.org/10.1557/jmr.1993.0501.
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The utilization of tensile strength of carbon fibers in unidirectional carbon/carbon (C/C) composites was studied for a series of four mesophase-pitch-based carbon fibers in a carbon matrix derived from a polyarylacetylene (PAA) resin. The fibers had moduli of 35, 75, 105, and 130 Mpsi. Composite processing conditions ranged from the cured-resin state to various heat-treatment temperatures (HTT's) from 1100 to 2750 °C for the C/C's. Room-temperature tensile strength and modulus were measured for the various processing conditions, and were correlated with SEM observations of fracture surfaces, fiber and matrix microstructures, and fiber/matrix interphase structures. Fiber tensile strength utilization (FSU) is defined as the ratio of apparent fiber strength in the C/C to the fiber strength in an epoxy-resin-matrix composite. Carbonization heat treatment to 1100 °C results in a brittle carbon matrix that bonds strongly with the three lower modulus fibers, resulting in matrix-dominated failure at FSU values of 24 to 35%. However, the composite with the 130-Mpsi-modulus filament had an FSU of 79%. It is attributed to a combination of tough fracture within the filament itself and a weaker fiber/matrix interface. Both factors lead to crack deflection and blunting rather than to crack propagation. The presence of a weakened interface is inferred from observations of fiber pullout. Much of the FSU of the three lower modulus fibers is recovered by HTT to 2100 or 2400 °C, principally as a result of interface weakening, which works to prevent matrix-dominated fracture. With HTT to 2750 °C, there is a drop in FSU for all the composites; it is apparently the result of a combination of fiber degradation and reduced matrix stress-transfer capability.
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Yu, Seok-Ho, Laura Pollard, Tim Wood, Heather Flanagan-Steet, and Richard Steet. "A Biochemical Platform to Define the Relative Specific Activity of IDUA Variants Identified by Newborn Screening." International Journal of Neonatal Screening 6, no. 4 (2020): 88. http://dx.doi.org/10.3390/ijns6040088.
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The lysosomal storage disorder, mucopolysaccharidosis I (MPSI), results from mutations in IDUA, the gene that encodes the glycosaminoglycan-degrading enzyme α-L-iduronidase. Newborn screening efforts for MPSI have greatly increased the number of novel IDUA variants identified, but with insufficient experimental evidence regarding their pathogenicity, many of these variants remain classified as variants of uncertain significance (VUS). Defining pathogenicity for novel IDUA variants is critical for decisions regarding medical management and early intervention. Here, we describe a biochemical platform for the characterization of IDUA variants that relies on viral delivery of IDUA DNA into IDUA-deficient HAP1 cells and isolation of single cell expression clones. The relative specific activity of wild-type and variant α-iduronidase was determined using a combination of Western blot analysis and α-iduronidase activity assays. The specific activity of each variant enzyme was consistent across different single cell clones despite variable IDUA expression and could be accurately determined down to 0.05–0.01% of WT α-iduronidase activity. With this strategy we compared the specific activities of known pseudodeficiency variants (p.His82Gln, p.Ala79Thr, p.Val322Glu, p.Asp223Asn) or pathogenic variants (p.Ser633Leu, p.His240Arg) with variants of uncertain significance (p.Ser586Phe, p.Ile272Leu). The p.Ser633Leu and p.His240Arg variants both show very low activities consistent with their association with Scheie syndrome. In our experiments, however, p.His240Arg exhibited a specific activity five times higher than p.Ser633Leu in contrast to other reports showing equivalent activity. Cell clones expressing the p.Ser586Phe and p.Ile272Leu variants had specific activities in the range of other pseudodeficiency variants tested. Our findings show that pseudodeficiency and pathogenic variants can be distinguished from each other with regard to specific activity, and confirms that all the pseudodeficiency variants variably reduce α-iduronidase activity. We envision this platform will be a valuable resource for the rigorous assessment of the novel IDUA variants emerging from the expansion of newborn screening efforts.
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S., K. Singh, Dutta Sujay, and Dharaiya Nishith. "MAPPING OF COTTON MEALYBUG (HEMIPTERA: PSEUDOCOCCIDAE) DAMAGE IN SIRSA DISTRICT, HARYANA USING GEOSPATIAL TECHNIQUE." International Journal of Engineering Sciences & Research Technology 5, no. 3 (2016): 138–46. https://doi.org/10.5281/zenodo.47007.
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Detection of crop stress is one of the major applications of remote sensing in agriculture. Many researchers have confirmed the ability of remote sensing techniques for detection of pest/disease on cotton. Hence, this research was designed to investigate, (1) to study the spectral properties of noninfested and mealybug infested cotton crop (ii) damage assessment using remote sensing derived index. Mealybug-infested cotton crop showed significantly lower reflectance in the near infrared region and higher in the visible region of the spectrum when compared with the non-infested cotton crop. Mealybug Pest Stress Index-8 (MPSI-8), a remote sensing index derived in this study shows a significant negative relationship with mealybug severity (r<sup>2</sup>=0.6319) and shows the potential to assessment the pest and disease damage because of its characteristic that include pigment, leaf structure, and water sensitive band. MPSI-8 depicts the change in pigment concentration and water stress and shows a negative relationship with mealybug severity. The high negative value of the index shows the high severity of mealybug. Land Surface Temperature (LST) also shows a positive and significant relationship with mealybug severity (r<sup>2</sup>=0.5921).Multiple linear regression analysis showed a strong relationships (r<sup>2</sup>=0.752) between mealybug severity and remotely derive index. Model developed in this study for the mealybug damage assessment in cotton crop yielded significant relationship (r<sup>2</sup>=0.752) and was applied on satellite data of 21<sup>st</sup> September 2009 which reveals high severity of mealybug and it was low on 24<sup>th</sup> September 2010 which confirms the significance of the model and can be used in the identification of mealybug infested cotton zones. These results indicate that remote sensing data have the potential to distinguish damage by mealybug and quantify its abundance in cotton.
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Jaspersen, Sue L., Adriana E. Martin, Galina Glazko, et al. "The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope." Journal of Cell Biology 174, no. 5 (2006): 665–75. http://dx.doi.org/10.1083/jcb.200601062.
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The spindle pole body (SPB) is the sole site of microtubule nucleation in Saccharomyces cerevisiae; yet, details of its assembly are poorly understood. Integral membrane proteins including Mps2 anchor the soluble core SPB in the nuclear envelope. Adjacent to the core SPB is a membrane-associated SPB substructure known as the half-bridge, where SPB duplication and microtubule nucleation during G1 occurs. We found that the half-bridge component Mps3 is the budding yeast member of the SUN protein family (Sad1-UNC-84 homology) and provide evidence that it interacts with the Mps2 C terminus to tether the half-bridge to the core SPB. Mutants in the Mps3 SUN domain or Mps2 C terminus have SPB duplication and karyogamy defects that are consistent with the aberrant half-bridge structures we observe cytologically. The interaction between the Mps3 SUN domain and Mps2 C terminus is the first biochemical link known to connect the half-bridge with the core SPB. Association with Mps3 also defines a novel function for Mps2 during SPB duplication.
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Messina, C., A. Rampazzo, S. Cesaro, et al. "Eighteen-year follow-up of the first Italian MPSI patient treated with bone marrow transplantation." Bone Marrow Transplantation 41, no. 10 (2008): 905–6. http://dx.doi.org/10.1038/sj.bmt.1705988.
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Wu, Gang, Long Chen, Chun Ling Deng, and Kun Wei. "Fabrication of Ofloxacin/PLGA Microsphere for Bone Tuberculosis Therapy." Advanced Materials Research 647 (January 2013): 176–80. http://dx.doi.org/10.4028/www.scientific.net/amr.647.176.
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The purpose of this research was to use mesoporous silicon (mpSi) as internal phase additive to improve the hydrophilic ofloxacin loaded by the hydrophobic PLGA materials through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Laser distribution analysis displayed low impact of MS additive on the final particles size. When compared to particle loading efficiency of none internal phase additives, MS internal phase group showed higher loading efficiency, and it increased with MS amounts inside the microparticles. All the burst releases of MS internal phase groups were severe than none MS group and was directly related the MS amount inside the microsphere. The release rate was increasing with the MS amounts added into the internal phase.
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Koirala, Nirajan, Jonathan Takeshita, Jeremy Stevens, and Taeho Jung. "Summation-based Private Segmented Membership Test from Threshold-Fully Homomorphic Encryption." Proceedings on Privacy Enhancing Technologies 2024, no. 4 (2024): 209–25. http://dx.doi.org/10.56553/popets-2024-0114.
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In many real-world scenarios, there are cases where a client wishes to check if a data element they hold is included in a set segmented across a large number of data holders. To protect user privacy, the client's query and the data holders' sets should remain encrypted throughout the whole process. Prior work on Private Set Intersection (PSI), Multi-Party PSI (MPSI), Private Membership Test (PMT), and Oblivious RAM (ORAM) falls short in this scenario in many ways. They either require data holders to possess the sets in plaintext, incur prohibitively high latency for aggregating results from a large number of data holders, leak the information about the party holding the intersection element, or induce a high false positive. This paper introduces the primitive of a Private Segmented Membership Test (PSMT). We give a basic construction of a protocol to solve PSMT using a threshold variant of approximate-arithmetic homomorphic encryption and show how to overcome existing challenges to construct a PSMT protocol without leaking information about the party holding the intersection element or false positives for a large number of data holders ensuring IND-CPA^D security. Our novel approach is superior to existing state-of-the-art approaches in scalability with regard to the number of supported data holders. This is enabled by a novel summation-based homomorphic membership check rather than a product-based one, as well as various novel ideas addressing technical challenges. Our PSMT protocol supports many more parties (up to 4096 in experiments) compared to prior related work that supports only around 100 parties efficiently. Our experimental evaluation shows that our method's aggregation of results from data holders can run in 92.5s for 1024 data holders and a set size of 2^25, and our method's overhead increases very slowly with the increasing number of senders. We also compare our PSMT protocol to other state-of-the-art PSI and MPSI protocols and discuss our improvements in usability with a better privacy model and a larger number of parties.
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Alvelo, Jaime, Andres A. Collazo, and David Rosario. "Comprehensive Assessment Tools for Hispanics: Validation of the Multi-Problem Screening Inventory (MPSI) for Puerto Ricans." Research on Social Work Practice 11, no. 6 (2001): 699–724. http://dx.doi.org/10.1177/104973150101100604.
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Ghbari, Thaer A. "How Does the Regulatory Focus Affect Problem-Solving Among Undergraduate Students?" New Educational Review 71, no. 1 (2023): 180–92. http://dx.doi.org/10.15804/tner.23.71.1.14.
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The current study aimed to explore the effect of regulatory Focus – Promotion vs. Prevention – in problem-solving among undergraduate students at The Hashemite University. The hypotheses were that promotion focus students outperform prevention focus students in ill-structured problems but underperform them in well-structured problems, and prevention focus students outperform promotion focus students in well-structured problems but underperform them in ill-structured problems. The participants (n=170) were allocated into four groups according to their mindsets and the problems assigned to them (promotion with ill-structured problems, promotion with well-structured problems, prevention with ill-structured problems, prevention with well-structured problems). After the groups solved all the assigned problems, their work was scored according to Measuring Problem Solving Instrument MPSI. The findings confirmed the hypothesis that the regulatory focus affects how problems are solved.
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Kaci, Anna, Emilie Adiceam, Melanie Dupont, et al. "Preclinical Activity of the MPS1 Inhibitor S81694 in Acute Lymphoblastic Leukemia (ALL)." Blood 134, Supplement_1 (2019): 2631. http://dx.doi.org/10.1182/blood-2019-125641.
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Introduction: The dual-specificity protein kinase, monopolar spindle 1 (Mps1) is one the main kinases of the spindle assembly checkpoint (SAC) critical for accurate segregation of sister chromatids during mitosis. A hallmark of cancer cells is chromosomal instability caused by deregulated cell cycle checkpoints and SAC dysfunction. Mps1 is known to be overexpressed in several solid tumors including triple negative breast cancer. Thus, Mps1 seems to be a promising target and small molecules targeting Mps1 entered clinical trials in solid tumors. ALL originates from malignant transformation of B-and T-lineage lymphoid precursors with a variety of genetic aberrations including chromosome translocations, mutations, and aneuploidies in genes responsible for cell cycle regulation and lymphoid cell development. While outcome is excellent for pediatric patients and younger adults, relapsed and refractory disease still remain a clinical challenge for elder patients. Here, we demonstrate for the first time preclinical efficacy of the small molecule Mps1 inhibitor (Mps1i) S81694 in T- and B- ALL cells including BCR-ABL1+-driven B-ALL. Materials and Methods: Expression of Mps1 was determined by RT-qPCR and WB in JURKAT, RS4-11 and BCR-ABL1+ cells (BV-173 and TOM-1). A small molecule Mps1i (S81694) was tested alone (0 to 1000nM) or in combination with imatinib, dasatinib, nilotinib and ponatinib in BCR-ABL1+ ALL cell lines. Cell viability and IC50 was assessed by MTS assays after exposure to Mps1i for 72h. In combination experiments, compounds were added simultaneously and relative cell numbers were determined at 72h with MTS assays and combination index (CI) values were calculated according to the Bliss model. Induction of apoptosis was evaluated by annexin-V exposure and PI incorporation at 72h with increasing doses of Mps1i. Cell-cycle distribution was determined by cytofluorometric analysis detecting nuclear propidium iodide (PI) intercalation at 48h. Phosphorylation of Mps1 was detected in synchronized (by nocodazole and MG-132) cells by immunofluorescence using an anti phospho-Mps1 antibody detecting Thr33/Ser37 residues. Time-lapse microscopy was used in cell lines in presence or absence of S81694 to determine mitosis duration. Bone marrow (BM) nucleated patient cells were obtained after informed consent and incubated in methylcellulose with cytokines with or without Mps1i for 2 weeks to determine colony growth. Results: Expression of Mps1 could be detected by RT-qPCR and at the protein level by WB in all cell lines (Figure 1A and B ). IC50 after Mps1i exposure alone was 126nM in JURKAT cells, 51nM in RS4-11 cells, 75nM in BV-173 cells and 83nM in TOM-1. Significant apoptosis as detected by phosphatidylserine exposure and PI incorporation in all cell lines with BCR-ABL1+ cell lines BV-173 and TOM-1 cells being the most sensitive (80% and 60% apoptotic cells respectively)(Figure 1C). Upon Mps1i exposure we observed targeted inhibition of Mps1 phosphorylation at Thr33/Ser37 residues indicating the specific on target effect of S81694 by inhibiting Mps1 autophosphorylation (Figure 1D and E). Cell cycle profile was generally lost after treatment with S81694 in all cell lines indicating aberrant 2n/4n distribution due to SAC abrogation (Figure 1F). Furthermore, we demonstrated that S81694 exposure accelerated significantly mitosis in BV-173 cell line from 36 minutes to 19 minutes indicating effective inhibition of SAC function (Figure 1G). Interestingly, S81694 induced significant apoptosis (70%) in the imatinib resistant BV173 cell line bearing the E255K-BCR-ABL1-mutation. Combination of S81694 with TKI imatinib, dasatinib and nilotinib (but not ponatinib) was strongly synergistic in BCR-ABL1+ cells (Figure 1H). Finally, we observed inhibition of colony formation in a patient with BCR-ABL1+ B-ALL after exposure to 100nM and 250nM S81694 (reduction of 85% and 100% respectively)(Figure 1I). Conclusion: Mps1i S81694 yields significant preclinical activity in T-and B-cell ALL including BCR-ABL1+ models. Interestingly S81694 was efficacious in a TKI resistant cell line. Disclosures Kaci: Institut de Recherches Internationales Servier (IRIS): Employment. Garrido:Institut de Recherches Internationales Servier (IRIS): Employment. Burbridge:Institut de Recherches Internationales Servier (IRIS): Employment. Dombret:AGIOS: Honoraria; CELGENE: Consultancy, Honoraria; Institut de Recherches Internationales Servier (IRIS): Research Funding. Braun:Institut de Recherches Internationales Servier (IRIS): Research Funding.
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Winey, M., L. Goetsch, P. Baum, and B. Byers. "MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication." Journal of Cell Biology 114, no. 4 (1991): 745–54. http://dx.doi.org/10.1083/jcb.114.4.745.
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It is crucial to the eucaryotic cell cycle that the centrosome undergo precise duplication to generate the two poles of the mitotic spindle. In the budding yeast Saccharomyces cerevisiae, centrosomal functions are provided by the spindle pole body (SPB), which is duplicated at the time of bud emergence in G1 of the cell cycle. Genetic control of this process has previously been revealed by the characterization of mutants in CDC31 and KAR1, which prevent SPB duplication and lead to formation of a monopolar spindle. Newly isolated mutations described here (mps1 and mps2, for monopolar spindle) similarly cause monopolar mitosis but their underlying effects on SPB duplication are unique. The MPS1 gene is found by electron microscopy to be essential for proper formation of the site at which the new SPB normally arises adjacent to the existing one. By contrast, a mutation in MPS2 permits duplication to proceed, but the newly formed SPB is structurally defective and unable to serve as a functional spindle pole. Distinct temporal requirements for the CDC31, MPS1, and MPS2 gene functions during the SPB duplication cycle further demonstrate the individual roles of these genes in the morphogenetic pathway.
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King, Kelly, Kyle Rudser, Victor Kovac, Igor Nestrasil, Kathleen Delaney, and Elsa Shapiro. "Visual memory and working memory as assessed by a computerized measure in individuals with mucopolysaccharidosis, Type I (MPSI)." Molecular Genetics and Metabolism 108, no. 2 (2013): S53. http://dx.doi.org/10.1016/j.ymgme.2012.11.128.
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Wang, Shao Hui, Zhong Yi Cai, Ming Zhe Li, and Ying Wu Lan. "Numerical Analysis of the Multi-Point Stretch Forming Process of Aircraft Outer Skin Part." Advanced Materials Research 154-155 (October 2010): 1068–72. http://dx.doi.org/10.4028/www.scientific.net/amr.154-155.1068.
Full textAbstract:
As a flexible manufacturing technique, Multi-point stretch forming (MPSF) is a suitable method for forming aircraft outer skin part. The traditional solid stretching die is replaced by the discrete multi-point die (MPSD), and the sheet metal is stretch-formed over the MPSD generated by serial adjusting mode or parallel adjusting mode. The MPSF can be used to form the parts of different shape and reduce the cost and leading time of stretching die fabrication for aircraft outer skin part. A series of numerical simulations on typical MPSF processes of aircraft outer skin part were carried out. The thickness of elastic cushion and free length are important factors to influence on the stretch forming results of stretch-formed parts. The numerical simulation results show that the thicker the elastic cushion is, the more valid the dimple will be suppressed .The longer the free length is, the easier the wrinkle will be brought.
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da Silva, Flávia, Vanessa Pereira, Eduardo G. Yasumura, et al. "Treatment of adult MPSI mouse brains with IDUA-expressing mesenchymal stem cells decreases GAG deposition and improves exploratory behavior." Genetic Vaccines and Therapy 10, no. 1 (2012): 2. http://dx.doi.org/10.1186/1479-0556-10-2.
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Rodriguez, M., I. Khimji, S. Rhodd, et al. "Combined home enzyme replacement therapy and unrelated cord blood transplantation for Hurler’s syndrome (MPSI) in a pediatric HSCT center." Biology of Blood and Marrow Transplantation 11, no. 2 (2005): 97. http://dx.doi.org/10.1016/j.bbmt.2004.12.286.
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Özekenci, Emre Kadir. "A Hybrid MPSI-Extended AROMAN Decision-making Model for Assessing Green Logistics Performance: The Case of Asia-Pacific Countries." Logforum 21, no. 1 (2025): 84–105. https://doi.org/10.17270/j.log.001154.
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