Relevant bibliographies by topics / (MPTP) 1-methyl-4-phenyl-1

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic '(MPTP) 1-methyl-4-phenyl-1'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '(MPTP) 1-methyl-4-phenyl-1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "(MPTP) 1-methyl-4-phenyl-1"

1

Singer, T. P., J. I. Salach, N. Castagnoli, and A. Trevor. "Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases." Biochemical Journal 235, no. 3 (1986): 785–89. http://dx.doi.org/10.1042/bj2350785.

Full text
Abstract:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a thermal breakdown product of a meperidine-like narcotic used by drug abusers as a heroin substitute, produces Parkinsonian symptoms in humans and primates. The nigrostriatal toxicity is not due to MPTP itself but to one or more oxidation products resulting from the action of monoamine oxidase (MAO) on this tertiary allylamine. Both MAO A and B catalyse the oxidation of MPTP to the 1-methyl-4-phenyl-2,3-dihydropyridinium species (MPDP+), which undergoes further oxidation to the fully aromatic 1-methyl-4-phenylpyridinium species (MPP+). Thes
APA, Harvard, Vancouver, ISO, and other styles
2

Herraiz, Tomás, Hugo Guillén та Juan Galisteo. "Metabolite Profile Resulting from the Activation/Inactivation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-Methyltetrahydro-β-carboline by Oxidative Enzymes". BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/248608.

Full text
Abstract:
Metabolic enzymes are involved in the activation/deactivation of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyiridine (MPTP) neurotoxin and its naturally occurring analogs 2-methyltetrahydro-β-carbolines. The metabolic profile and biotransformation of these protoxins by three enzymes, monoamine oxidase (MAO), cytochrome P450, and heme peroxidases (myeloperoxidase and lactoperoxidase), were investigated and compared. The metabolite profile differed among the enzymes investigated. MAO and heme peroxidases activated these substances to toxic pyridinium andβ-carbolinium species. MAO catalyzed the oxi
APA, Harvard, Vancouver, ISO, and other styles
3

Sasahara, Tais H. C., and Marcia R. F. Machado. "The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology." Pesquisa Veterinária Brasileira 39, no. 5 (2019): 364–70. http://dx.doi.org/10.1590/1678-5150-pvb-5808.

Full text
Abstract:
ABSTRACT: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mou
APA, Harvard, Vancouver, ISO, and other styles
4

Krueger, M. J., K. McKeown, R. R. Ramsay, S. K. Youngster, and T. P. Singer. "Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines." Biochemical Journal 268, no. 1 (1990): 219–24. http://dx.doi.org/10.1042/bj2680219.

Full text
Abstract:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its primary oxidation product, 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+), are mechanism-based inhibitors of monoamine oxidases A and B. The pseudo-first-order rate constants for inactivation were determined for various analogues of MPTP and MPDP+ and the concentrations in all redox states were measured throughout the reaction. Disproportionation was observed for all the dihydropyridiniums, but non-enzymic oxidation was insignificant. The dihydropyridiniums were poor substrates for monoamine oxidase A and, consequently, inactivated t
APA, Harvard, Vancouver, ISO, and other styles
5

Lv, Chuanfeng, Tie Hong, Zhen Yang, et al. "Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/928643.

Full text
Abstract:
In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated. Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days. The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na+, K+-ATPase, AchE
APA, Harvard, Vancouver, ISO, and other styles
6

Jarvis, M. F., and G. C. Wagner. "Age-dependent effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)." Neuropharmacology 24, no. 6 (1985): 581–83. http://dx.doi.org/10.1016/0028-3908(85)90068-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Cataldi, Samuela, Michela Codini, Stéphane Hunot, et al. "e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease." Mediators of Inflammation 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/3937057.

Full text
Abstract:
Today a large number of studies are focused on clarifying the complexity and diversity of the pathogenetic mechanisms inducing Parkinson disease. We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that induces Parkinson disease, to evaluate the change of midbrain structure and the behavior of the anti-inflammatory factor e-cadherin, interleukin-6, tyrosine hydroxylase, phosphatase and tensin homolog, and caveolin-1. The results showed a strong expression of e-cadherin, variation of length and thickness of the heavy neurofilaments, increase of interleukin-6, and reduction
APA, Harvard, Vancouver, ISO, and other styles
8

Bandaru, Nagaraju, Namanda Shamim, Siripalli Bhagaya Nagalakshmi, et al. "Preparation of Platinum Nanoparticles of Biophytum reinwardtii and Evaluation of Neuroprotective Activity of MPTP-induced Parkinson’s Disease in Zebra Fish." Biomedical and Pharmacology Journal 17, no. 3 (2024): 1635–45. http://dx.doi.org/10.13005/bpj/2971.

Full text
Abstract:
Aim: To evaluate the Neuroprotective activity of Biophytum reinwardtii Platinum nanoparticles Methods: Biophytum reinwerdtii platinum nanoparticles were subjected to evaluation of the neuroprotection activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced zebra fishes. Experimental fishes are divided into 5 groups, each containing 8 fishes. Group I is considered a normal group; Group II is a toxic group means treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 225 mg/kg, i.p. for 5 days; Group III, IV, and V are treatment groups means treated with 1-methyl-4-phenyl-1,2,3,6-tetra
APA, Harvard, Vancouver, ISO, and other styles
9

Venables, Maddie J., Lei Xing, Connor C. Edington, and Vance L. Trudeau. "Neuronal regeneration in the goldfish telencephalon following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) insult." FACETS 3, no. 1 (2018): 358–74. http://dx.doi.org/10.1139/facets-2017-0119.

Full text
Abstract:
The constitutive regenerative ability of the goldfish central nervous system makes them an excellent model organism to study neurogenesis. Intraperitoneal injection of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was used to deplete tyrosine hydroxylase-positive neurons in the adult goldfish telencephalon. We report novel information on the ability of the goldfish to regenerate (∼3–4 d post-MPTP insult) damaged neurons in telencephalic tissue by observing the rapid incorporation of bromodeoxyuridine into newly generated cells, which precedes the recovery of motor function in
APA, Harvard, Vancouver, ISO, and other styles
10

Yokoyama, Hironori, Hayato Kuroiwa, Jiro Kasahara, and Tsutomu Araki. "Neuropharmacological approach against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine)-induced mouse model of Parkinson’s disease." Acta Neurobiologiae Experimentalis 71, no. 2 (2011): 269–80. http://dx.doi.org/10.55782/ane-2011-1847.

Full text
Abstract:
Parkinson’s disease (PD) is a common neurodegenerative disease that appears essentially as a sporadic condition. PD is well known to be a chronic and progressive neurodegenerative disease produced by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main clinical features of PD include tremor, bradykinesia, rigidity and postural instability. Most insights into pathogenesis of PD come from investigations performed in experimental models of PD, especially those produced by neurotoxins. The biochemical and cellular alterations that occur after 1-methyl-4-
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "(MPTP) 1-methyl-4-phenyl-1"

1

Bucy, Teresa B. "Studies on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and analogs." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-09052009-040222/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Santoro, Matteo. "The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models of Parkinson's disease characterising behaviour and inflammation." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=236467.

Full text
Abstract:
Parkinson's disease (PD) is a progressive neurodegenerative disorder with evolving layers of complexity. In the present thesis we replicated the PD neurodegenerative pattern using a mouse model characterized by systemic injections of the neurotoxin 1-methyl-4-phenyl1,2,3,6-tethrahydropyridine (MPTP). Firstly, we investigated the role of a pro-inflammatory mediator called high mobility group box 1 (HMGB1), in-vivo and in post-mortem human tissue of PD patients. Our study shows increased protein levels of HMGB1 in substantia nigra of PD patients and MPTP treated mice. Inhibition of HMGB1, using
APA, Harvard, Vancouver, ISO, and other styles
3

Mounsey, Ross B. "Pharmacological and genetic modifications in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196259.

Full text
Abstract:
Parkinson’s disease (PD) is a common chronic neurodegenerative disorder, usually of idiopathic origin. Symptoms including tremor, bradykinesia, rigidity and postural instability are caused by the progressive loss of dopaminergic neurons in the nigrostriatal region of the brain. Symptomatic therapies are available but no treatment slows or prevents the loss of neurons. To this end, the present study utilises the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to reproduce the pattern of cell death evident in PD patients. Several processes have been implicated in its pathogenesis
APA, Harvard, Vancouver, ISO, and other styles
4

Harris, Dana N. "Quantitative structure activity relationships of monamine oxidase catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs." Thesis, Virginia Tech, 1996. http://hdl.handle.net/10919/44451.

Full text
Abstract:
Studies into the quantitative structure act! Vlty relationships of rate s of I-methyl-4-phenyl-l,2,3,6-tetrahydropyridine oxidation catalyzed by monoamine oxidases A and B were performed to elucidate active site substrate conformation and oxidation mechanisms. Plotting experimental kinetic activity against molecular properties obtained by experiment and by computational chemistry methods demonstrated correlations with lipophilic, steric, and electronic factors. Compounds studied were 4-aryloxy analogs, 4- aromatic heterocycle analogs, and 4-phenyl analogs. The conformer with phenyl ring to tet
APA, Harvard, Vancouver, ISO, and other styles
5

Song, Xiaoou. "A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-08082007-120224/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Chan, Wing-yan Veronica, and 陳詠恩. "An examination of neuroprotective effects of 17B-estradiol and extracts from Panax Quinquefolius L., Ginkgo Biloba and HypericumPerforatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)induced nigral-striatal neuronal degeneration." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122720X.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Thota, Anil K. "Biomechanical Assessment of Normal and Parkinsonian Gait in the Non-human Primate During Treadmill Locomotion." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1338821968.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

"In vivo and in vitro studies on the role of metallothionein in MPTP/MPP⁺-induced neurotoxicity." 2000. http://library.cuhk.edu.hk/record=b5890436.

Full text
Abstract:
by Wai Yuen.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 123-157).<br>Abstracts in English and Chinese.<br>Acknowledegment --- p.iv<br>Abstract --- p.v<br>List of Abbreviations --- p.ix<br>Chapter CHAPTER ONE: --- INTRODUCTION<br>Chapter 1.1 --- Parkinson's Disease (PD) --- p.1<br>Chapter 1.1.1 --- Epidemiology --- p.1<br>Chapter 1.1.2 --- Neuropathology --- p.2<br>Chapter 1.1.3 --- Clinical Symptoms --- p.3<br>Chapter 1.1.4 --- Treatment --- p.6<br>Chapter 1.2 --- Proposed Mechanisms of Neurodegeneration in PD --- p.11<br
APA, Harvard, Vancouver, ISO, and other styles
9

Hsu, Yi-Ling, and 許怡玲. "1.The effect of chronic treatment of 1-methyl-4-phenyl-1,2,3,6- tetrahdro-pyridine (MPTP) on the plasma concentration of adrenocoricotrophic hormone (ACTH) and corticotropin- releasing factor (CRF) in C57BL/6J mice. 2.The effect of chronic treatm." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/90088002127290819345.

Full text
Abstract:
碩士<br>台北醫學院<br>細胞及分子生物研究所<br>88<br>We have determined the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the releasing corticotropin releasing factor (CRF) and adrenocoricotrophic hormone (ACTH) by quantifying the plasma level CRF and ACTH using radioimmuno-assay (RIA) and enzyme-linked-immuno sorbent assay (ELISA) in the C57BL/6J mice with 7 days treatment of MPTP. We found that MPTP treatment did not affect the plasma level of CRF, but transiently increase in the plasma level of ACTH at 1st day after continuation MPTP treatment. This result suggested that chronic MPTP treat
APA, Harvard, Vancouver, ISO, and other styles
10

Caria, Inês de Sousa. "Unanswered Role of Cholesterol Homeostasis in Parkinson’s Disease." Master's thesis, 2020. http://hdl.handle.net/10362/96664.

Full text
Abstract:
Cholesterol has a key role in neuronal function and alterations in brain cholesterol homeostasis correlate with neurodegeneration. While disruptions in cholesterol homeostasis have been clearly associated with neurodegenerative disorders such as Alzheimer’s and Huntington’s disease, the role of cholesterol in Parkinson’s disease (PD) remains controversial. To address this question, we characterized changes in cholesterol intracellular localization and levels using N2a mouse neuroblastoma cells treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxic metabolite, 1-methyl-4-p
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "(MPTP) 1-methyl-4-phenyl-1"

1

D, Parkes J., ed. MPTP and the aetiology of Parkinson's disease: Clinical implications. Springer-Verlag, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Bhatti, Akmal Riaz. Synthesis and investigation of analogues of N-methyl-4- phenyl-1, 2, 3, 6-tetrahydropyridine, (MPTP), a specific dopaminergic neurotoxin. University of Birmingham, 1988.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

München, Universität, ed. Wirkungen von 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridin (MPTP) und seinen Metaboliten auf Säugetierneurone in vitro. 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Onaivi, Emmanuel Shan. Behavioural and biochemical consequences of bilateral and unilateral infusion of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) into the caudate putamen and substantia nigra of the rat brain. 1985.

Find full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "(MPTP) 1-methyl-4-phenyl-1"

1

Kinemuchi, Hiroyasu, Yuichiro Arai, Yoshie Toyoshima, Takeshi Tadano, and Kensuke Kisara. "Relations between MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine), the Neurotoxin MPP+ (1-Methyl-4-Phenylpyridinium Ion), and MAO in Rat Brain." In Neuropsychopharmacology of the Trace Amines. Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-5010-4_14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lange, Klaus W. "Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4684-5844-2_119.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Nakayama, H., T. Ito, Y. Shibui, T. Sai, K. Uchida, and X. J. He. "Neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a Parkinson’s Disease Model." In Handbook of Neurotoxicity. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-5836-4_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Jenner, P., and C. D. Marsden. "Parkinsonian Syndrome Caused by 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Man and Animals." In Selectivity and Molecular Mechanisms of Toxicity. Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-08759-4_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Sandy, Martha S., Donato Di Monte, Phyllis Cohen, and Martyn T. Smith. "Role of Active Oxygen in Paraquat and 1-Methyl-4-phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Cytotoxicity." In Oxygen Radicals in Biology and Medicine. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5568-7_127.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Imai, Hisamasa, Toshiki Nakamura, Kiyonori Endo, and Hirotaro Narabayashi. "Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4684-5844-2_56.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Sullivan, J. P., and K. F. Tipton. "The interactions of monoamine oxidase with some derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)." In Neurotransmitter Actions and Interactions. Springer Vienna, 1990. http://dx.doi.org/10.1007/978-3-7091-9050-0_26.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Tadano, Takeshi, Nobunori Satoh, Katsuyuki Oyama, Kensuke Kisara, Yuichiro Arai, and Hiroyasu Kinemuchi. "Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice." In Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Springer New York, 1990. http://dx.doi.org/10.1007/978-1-4684-5844-2_59.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Goto, Keigo, Hideki Mochizuki, Hisamasa Imai, Haruhiko Akiyama, and Yoshikuni Mizuno. "A Histochemical Study of Iron and Ferritin in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Hemiparkinsonian Monkeys." In Advances in Behavioral Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0194-1_45.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Pihan, German, and Sandor Szabo. "The Dopaminergic Neurotoxin 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyrine (MPTP) is a New Duodenal Ulcerogen in the Rat." In Ulcer Disease. CRC Press, 2024. https://doi.org/10.1201/9781003574712-31.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic '(MPTP) 1-methyl-4-phenyl-1' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography