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Dissertations / Theses on the topic 'MRC5 Cell'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Igor, Đan. "Radiobiološki efekti niskih pre-iradijacionih doza jonizujućeg zračenja na humane ćelijske linije HT29 i MRC5." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=100268&source=NDLTD&language=en.

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Radioterapija (RT) je jedan od najvažnijih modaliteta lečenja solidnih malignih tumora i koristi je vi&scaron;e od 50% pacijenata (52,3%) sa malignim tumorima. Nauka koja proučava efekte elektromagnetnog zračenja na biolo&scaron;ke sisteme naziva se radiobiologija. Radiobiologija se fokusira na odgovor ćelija, tkiva i organizma kao celine na jonizujuće zračenje i proučava mehanizme radiobiolo&scaron;kog odgovora. Izlaganje ćelija niskim dozama JZ koje su nakon određenog vremenskog intervala praćene uobičajenim radioterapijskim dozama naziva se radioadaptivno zračenje. Adaptivni odgovor u sebi

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2

Arigony, Ana Lúcia Vargas. "Avaliação do efeito do micronutriente ferro (Fe) na viabilidade celular e estabilidade genômica de culturas celulares de fibroblasto pulmonar (MRC5) e hepatorcarcinoma (HepG2) humanos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/78152.

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Micronutrientes, vitaminas e minerais, são indispensáveis para as vias de metabolismo do DNA e, além disso, são tão importantes para a manutenção da vida quanto os macronutrientes. Na ausência dos nutrientes adequados, a instabilidade genômica compromete a homeostase, ocasionando doenças crônicas e certos tipos de câncer. Meios de cultura celular tem por finalidade mimetizar o ambiente in vivo, proporcionando aos modelos in vitro condições adequadas para que se avalie a resposta celular aos diferentes estímulos. O artigo de revisão sumariza e discute os micronutrientes usados na suplementação

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3

Yates, Sally A. "The cytotoxic effects of malondialdehyde on human lung fibroblast cells." Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4529/.

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Malondialdehyde (MDA) is a mutagenic and carcinogenic product of lipid peroxidation which has also been found at elevated levels in smokers. MDA reacts with nucleic acid bases to form pyrimidopurinone DNA adducts, of which 3-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimidol[1,2-α]purin-10(3H)-one (M1dG) is the most abundant and has been linked to smoking. Mutations in the TP53 tumour suppressor gene are associated with half of all cancers. This research applied a multidisciplinary approach to investigate the toxic effects of MDA on the human lung fibroblasts MRC5, which have an intact p53 response

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4

Wilkinson, Simon. "Characterisation of human MRCK protein kinase and its signalling role in cancer cells: regulation of cell invasion." Thesis, Institute of Cancer Research (University Of London), 2005. http://publications.icr.ac.uk/9713/.

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This thesis describes the characterisation of human MRCKcc (myotonic dystrophy kinase-related Cdc42-binding kinase) and the signalling role of MRCK in tumour cell invasion. The first results chapter reports the identity and sequence of the human isoform of MRCKa. It is shown that previously reported expression of a sequence known as PK428 in breast tumours with poor prognosis represents MRCKa expression. PK428 is identified as a partial cDNA of the previously uncloned human MRCKa. The cloning of several splice-variants of full-length MRCKa is described. MRCKa expression is also analysed in hum

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5

Braesch-Andersen, Ken. "Temperature dependence in human Rhinovirus infection of human MRC-5." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392331.

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Temperature has been known to be an important factor for in vitro studies where human cell cultures are infected with HRV (human Rhinovirus). The mechanisms behind the temperature effect on the struggle between virulence and cellular defense, are still largely unknown and may be a crucial part in finding a treatment to the common cold. In this study we focused on a few cellular key elements in this struggle and observed behavior changes in regards to the pre-infection growth temperature and the temperature during the viral infection. Past studies have focused mainly on the temperature post ino

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6

Chastonay, José de. "Replication of the hepatitis A virus in MRC-5 cells /." [S.l : s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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7

Allouche, Farouk. "Role of RANKL in the differentiation of B cell associated stroma in secondary lymphoid organs." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ002.

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RANKL (ligand du récepteur activateur de NF-KB) est un membre de la famille des TNF dont la signalisation passe par RANK et qui joue un rôle important dans la régulation immunitaire. Chez l'adulte, RANKL est exprimé constitutivement par des cellules réticulaires marginales (MRC) des ganglions lymphatiques. Comme les MRCs sont physiquement proches des lymphocytes B (LB) et ont été proposé d’être des précurseurs de cellules dendritiques folliculaires (FDC), RANKL pourrait jouer un rôle dans la différenciation du stroma associé aux LB et dans la réponse humorale. Afin de mieux comprendre la fonct

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8

Karki, Surya B. "Non-thermal Miniature Dielectric Barrier Discharge Plasma for Treatment ofLung Carcinoma Cells." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1523017849495564.

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9

Stoner, Terri Dorene. "Indole-3-Carbinol Inhibition of Herpes Simplex Virus Replication." Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1228328838.

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10

Cunha, Luiz Antônio da. "Avaliação da influência do dipeptídeo N-ß-alanil-L-histidina (L- carnosina) sobre a cinética de expansão de culturas de células diplóides humanas, estirpe MRC-5." Instituto de Tecnologia em Imunobiológicos, 2007. https://www.arca.fiocruz.br/handle/icict/5812.

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Submitted by Priscila Nascimento (pnascimento@icict.fiocruz.br) on 2012-11-14T17:52:45Z No. of bitstreams: 1 luiz-antonio-da-cunha.pdf: 2013128 bytes, checksum: 0e5dc52de1e8d6ce612c04c856313ff7 (MD5)<br>Made available in DSpace on 2012-11-14T17:52:45Z (GMT). No. of bitstreams: 1 luiz-antonio-da-cunha.pdf: 2013128 bytes, checksum: 0e5dc52de1e8d6ce612c04c856313ff7 (MD5) Previous issue date: 2007<br>Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.<br>Um acordo internacio

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11

Abrefa, Darlington Osei. "Genetic Study of Checkpoint Defects of the Mus81-1 Mutant in the Fission Yeast Schizosaccharomyces Pombe." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578464554813491.

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12

Saboktakin, Rizi Bahareh. "Monitoring Dielectric Properties of Single MRC5 Cells and Oligomycin Treated Chinese Hamster Ovary Cells Using a Dielectrophoretic Cytometer." 2014. http://hdl.handle.net/1993/24054.

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We have employed a differential detector combined with dielectrophoretic (DEP) translation in a microfluidic channel to monitor dielectric response of single cells and particularly to track phenomenon related to apoptosis. Two different cell lines were studied; Chinese hamster ovary cells (CHO) and MRC5 cells. Dielectric response was quantified by a factor called Force Index. Force Index was studied statistically to identify apoptotic subpopulations. Another direction of this work was to monitor changes in the cytoplasm conductivity following inhibition of mitochondrial ATP production by

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13

Jeng-Sheng, Wu, and 吳瑞昇. "Studies on the Pathway of Cell Death Triggered by Cadmium and Mercury in Human Normal Lung Cell MRC-5." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/97155841996348439824.

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碩士<br>台北醫學院<br>醫學研究所<br>90<br>Epidemiological evidence has suggested that exposure of the human to cadmium (Cd) and mercury (Hg) might cause pulmonary damages. However, the mechanism has remained unclear. A normal human fetal lung fibroblast cell line (MRC-5) was used as a cell model to investigate the mechanism of cell death triggered by Cd or Hg. Several methods were employed to elucidate apoptosis and necrosis of MRC-5 cells after treatment of 100μM Cd or Hg, respectively; including cytohistochemistry analysis with Hoechst staining, flow cytometric assay with propidium iodide (PI) single st

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14

Urena, Ramirez Viridiana. "Development of reduced serum-free media for MRC-5 and Vero cells using definitive screening design." 2017. http://hdl.handle.net/1993/32237.

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The purpose of this study was to rationally design animal component free, chemically defined serum free media (ACF-CD-SFM) for MRC-5 and Vero cells while adhering to the Quality by Design guidelines. This was achieved by using the Modified Vero Serum Free Medium (MVSFM) as the basal formulation and supplementing it with various combinations of growth factors (LONG® EGF, LONG® R3 IGF-I, rTransferrin, bFGF, TGF-3 and PDGF-AA), lipids (linoleic acid, cholesterol, and dexamethasone), lipid precursors (ethanolamine and phosphoethanolamine) and vitamins (all-trans retinoic acid, -tocopherol and asco

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15

Ramos, Carina Isabel Mártires. "Evaluation of Bisphenol A genotoxicity and interference on Doxorubicin effects in HEp-2 and MRC-5 cell lines." Master's thesis, 2017. http://hdl.handle.net/10451/30601.

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Tese de mestrado em Biologia Molecular e Genética, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017<br>Introdução: Atualmente vivemos numa sociedade desenvolvida em diversas áreas do conhecimento. Na base deste desenvolvimento, podemos encontrar a indústria química responsável por várias matérias-primas (químicos) que possibilitam a evolução de outras áreas. Este progresso leva a uma diminuição do controlo sobre a libertação destes químicos para o ambiente e, consequentemente torna inevitável permanente exposição de humanos, animais e plantas a estes agentes. Entre

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16

Lang, Yaw-Dong, and 藍耀東. "The Molecular Mechanism of Paraquat-induced Collagen Production in Human Lung Fibroblast MRC-5 Cells." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/84078775563718198216.

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碩士<br>臺北醫學大學<br>醫學研究所<br>94<br>Paraquat dichloride (1,1-dimethyl-4,4-bipyridilium dichloride; methyl viologen) is an effective and widely used herbicide. According to epidemiological evidence in the National Poison Center in Taiwan, paraquat poisoning has suggested that was the leading cause of poisoning-induced death in Taiwan. In this study, the normal human fetal lung fibroblast cell line (MRC-5) was used to study the mechanism of paraquat-induced pulmonary fibrosis for eliminating the effect of paraquat nephrotoxicity on renin-angiotensin system (RAS). The results showed that paraquat-indu

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17

Wang, Chia-Jen, and 王嘉媜. "Study on the Effects of ROS during Apoptosis Triggered by Cadmium and Mercury in Human Normal Lung Cell MRC-5." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/14507749521979863332.

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碩士<br>台北醫學院<br>醫學研究所<br>88<br>Epidemiological evidence suggested that cadmium (Cd) and mercury (Hg) exposure might cause pulmonary damage. However, the mechanisms were not clear yet. Cd or Hg had been reported to induce apoptosis in some cell lines and might correlate with redox signaling. In our research, a normal human fetal lung fibroblast cell line (MRC-5) was used as a cell model to investigate the effects of reactive oxygen species (ROS) during apoptosis triggered by Cd or Hg. Among numerous antioxidant compounds or enzymes, N- acetylcysteine (NAC)、pyrrolidine dithiocarbamate (PDTC)、asco

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18

Hsiao, Hung-Ju, and 蕭虹如. "Adaptation Mutation Glu345Lys of Infectious cDNA Clone-derived Dengue Type 4 Vaccine Virus in MRC-5 Cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/22384039743579884926.

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碩士<br>國立清華大學<br>生物科技研究所<br>98<br>Passage of virus in different cell lines is possible to produce host-cell specific mutations, which may affect cell tropism and virus virulence. We have previously reported that a dengue type 4 virus vaccine candidate passaged in human fetal lung fibroblast (MRC-5) cells rapidly acquired a Glu345-Lys substitution in the envelope protein domain III (Liu et al., PLoS ONE, 2008;e1810). It was also reported that another Glu327Gly substitution of the same vaccine candidate was selected after three passages in fetal rhesus lung (FRhL) cells with reduced infectivity a

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19

Chang, Kang-Wei, and 張剛瑋. "The Toxicity of Environment Carcinogen-benzo[a]pyrene and Cooking Oil Fume In Lung Cell Lines (CL-3、MRC-5 and A427)." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/81573705335119956888.

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碩士<br>中山醫學院<br>毒理學研究所<br>86<br>This thesis was to study the toxicity of environmental carcinogenbenzo[a]pyrene (B[a]P) and cooking oil fume (COF) in lung cell lines (CL-3, MRC-5 and A427). First we examined effects of 24 hrs treatment with 1 or 10 μM B[a]P on cell growth. Viable CL-3 cell number was reduced to only 42% or 22% of control at 96 hr after removal of B[a]P. However, viable A427 cell number was similar between control and B[a]P treated cells. Second, we utilized the Comet assay to detect DNA single strand break. After 10 μM B[a]P treatment for 24 hrs, the tail moment of CL-3 cell in

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20

Patino, Descovich Carlos. "Characterizing cortical myosin mini-filament regulation, length and its macroscopic implications in cytokinetic dynamics." Thèse, 2013. http://hdl.handle.net/1866/11328.

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21

Wang, HsueChun, та 王雪君. "Mechanisms of gaseous nitric oxide promoting lung cancer(一)Formation of 8-NO2-G in MRC-5 cells(二)The signaling transduction pathway involvement of iNOS activation )". Thesis, 2000. http://ndltd.ncl.edu.tw/handle/77112889960328533969.

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碩士<br>中山醫學院<br>生物化學研究所<br>88<br>Nitric oxide (NO) is a common indoor and outdoor environmental toxic pollutant arising from gas and wood-burning stoves, and emissions from auto-motive and other combustion engines. There is considerable evidence to suggest that NO-induced injury in mammalian lung cells. NO may cause DNA or tissue damage, contributing to the multistage carcinogenesis. We demonstrated that 8-nitroquanine was formed time- and dose- dependently in human lung fibroblast cells (MRC-5) exposed to gaseous NO. These results suggest that 8-nitroquanine could act as a specific marker for

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22

Renaud, Matthew. "Development of an in vitro Method to Determine Nickel Toxicity and Carcinogenicity." Thesis, 2012. http://hdl.handle.net/10214/3632.

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Nickel is a widely used metal in industrial and commercial applications, being both workable and highly resistant to corrosion. Certain nickel compounds are known human carcinogens, but not all nickel compounds are equally hazardous. A robust method of assessing the carcinogenic potential of various nickel compounds is needed in order to determine safe occupational exposure levels. This work attempts to develop an in vitro mammalian cell culture method for assessing the carcinogenic and toxic potential of nickel compounds by metabolic and cell cycle analysis. Two cell lines, C3H/10T1/2 and MRC

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