Relevant bibliographies by topics / MRKH syndrom

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'MRKH syndrom'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "MRKH syndrom"

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Anant, Monika, Nutan Raj, Neelu Yadav, Arun Prasad, Subhash Kumar, and Ajit K. Saxena. "Two Distinctively Rare Syndromes in a Case of Primary Amenorrhea: 18p Deletion and Mayer–Rokitansky–Kuster–Hauser Syndromes." Journal of Pediatric Genetics 09, no. 03 (October 30, 2019): 193–97. http://dx.doi.org/10.1055/s-0039-1700577.

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AbstractMayer–Rokitansky–Kuster–Hauser (MRKH) syndrome and 18p deletion syndrome, two genetic disorders having distinct genetic etiologies, have an exceedingly rare likelihood of coexistence. Vaginal agenesis or MRKH syndrome, the developmental failure of Mullerian ductal system-derived structures in a genotypic female fetus (46, XX), leads to congenital absence of uterus and vagina in variable degree. The 18p deletion syndrome is a rare chromosomal disorder, characterized by dysmorphic features, stunted growth, and mental retardation, which is caused by deletion of a part or all of the short arm of chromosome 18. A detailed evaluation of primary amenorrhea in a 16-year-old girl yielded both MRKH syndrome and 18p deletion syndrome. Extensive literature search could not identify any reported case bearing this combination of syndromes. This case presentation and review emphasizes on the importance of karyotyping in MRKH patients having atypical features.
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Meng, Tian, Ming Bai, and Ru Zhao. "Congenital Malformations of the Reproductive Tract in a Patient with Poland Syndrome: Is There a Connection." Breast Care 12, no. 5 (2017): 340–43. http://dx.doi.org/10.1159/000478086.

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Background: Poland syndrome and Müllerian duct agenesis (Mayer-Rokitansky-Küster-Hauser(MRKH)-like syndrome) are two rare congenital anomalies with unclear etiology. Case Report: An 18-year-old female presented with hypoplasia of the left pectoralis muscles and subcutaneous tissue, hypoplasia of the left breast and nipple, and dextrocardia, typical in those with a severe form of Poland syndrome. She also showed aplasia of the vagina and uterus, bilateral ovarian agenesis, and hyperandrogenism, presenting as MRKH-like syndrome. Conclusion: It is plausible to assume that these two congenital anomalies which arose from distant sites may be interrelated. More cases and further studies will certainly help delineate the pathogenesis of these syndromes.
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Petric, Aleksandra, Milan Stefanovic, Predrag Vukomanovic, Radomir Zivadinovic, Aleksandra Tubic, and Zoran Janjic. "Acute abdomen in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome." Vojnosanitetski pregled 65, no. 9 (2008): 706–9. http://dx.doi.org/10.2298/vsp0809706p.

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Background. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a malformation of female genital tract (incidence 1 in 4000 female newborn children). It appears as a result of a disorder in the development of Millerian cannals. Etiology is unknown. Syndrome MRKH is the most frequent cause of primary amenorrhoea (90%). Patients with MRKH have a normal female phenotype, with normal pubic hairness and thelarche, and female karyotype (46XX) followed by primary amenorrhoea. Hormonal status corresponds to healthy women, where the appearance of ovarian tumors and tumors on rudiment parts of uterus is possible. Case report. We presented a case of acute abdomen in a patient with previously not diagnosed MRKH. The diagnosis was done during the operation. Small pelvis and an abdominal part were filled with torquated tumor lump, where ovaries, oviducts, uterus or something resembling rudiment of uterus were not recognized through careful examination. Furthemore, the patient had a short, dead-end vagina. Tumorectomy was done and hystopathological finding showed the presence of vascular leiomyoma. Conclusion. The diagnosis of complex syndromes, such as MRKH, can, despite modern diagnostics, be absent for non-medical and psycho-social reasons. We can expect ovarian and uterine pathology on hypoplastic structures in these patients, as well as in healthy women. Vascular leiomyoma in the patients with MRKH was not found in the available literature.
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Daniel, Guerrier, and Morcel Karine. "Partial SHOX duplications associated with various cases of congenital uterovaginal aplasia (MRKH syndrome): A tangible evidence but a puzzling mechanism." Journal of Genetic Medicine and Gene Therapy 4, no. 1 (March 24, 2021): 001–8. http://dx.doi.org/10.29328/journal.jgmgt.1001006.

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The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most severe form of congenital malformation of the inner female reproductive tract. It is diagnosed as such when the uterus, the upper vagina and optionally the Fallopian tubes are absent. It accounts for approximately 1 in 5000 live-born females and has been classified in two subtypes: type 1 in the presence of isolated uterovaginal aplasia and type 2 when associated in various combinations with extragenital malformations of the kidneys, skeleton, heart and auditory system. Most cases of MRKH syndrome are sporadic, although a significant number of many familial cases have been reported to date. Despite numerous studies, the genetics of the syndrome remains largely unknown and appears to be heterogeneous: chromosomal abnormalities and some candidate gene variants appear to be associated with a few cases; others have been suggested but not yet confirmed. To date, mainly the GREB1L gene appears to be a serious candidate. Among the remaining hypotheses, the controversial contribution of partial duplications of the SHOX gene is still puzzling, as the deficiency of this gene is a major cause of skeletal adysplasia syndromes. We have attempted to resolve this controversy in a study of 60 MRKH cases. Our results tend to show that SHOX duplications can be the origin of a genetic mechanism responsible for MRKH syndrome.
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Khan, Washim F., Yashwant S. Rathore, Manjunath M. Pol, and Gurpremjit Singh. "Inguinal hernia with ovary as content- laparoscopic repair in a Mayer–Rokitansky–Küster–Hauser syndrome patient: case report." International Surgery Journal 6, no. 4 (March 26, 2019): 1421. http://dx.doi.org/10.18203/2349-2902.isj20191293.

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Inguinal hernia is a common surgical disease. Ovary and fallopian tube are not frequently found as content of the hernia. A 18 year old female, diagnosed case of Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome, presented with left sided reducible inguinal hernia for six months. Ultrasonography revealed absence of intra-abdominal left ovary and presence of ovary in the sac. She was planned for laparoscopic repair and total extra-peritoneal repair (TEP) was done. Ovary and adnexa may be content in groin hernia in females. Association of syndromes especially MRKH syndrome should be kept in mind in this group of patients. Laparoscopic total extra-peritoneal repair may be successfully attempted in this group of patients.
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Akhter, Nasreen, and Badrunnesa Begum. "Evaluation and management of cases of primary amenorrhoea with MRKH syndrome." Bangladesh Medical Journal Khulna 45, no. 1-2 (February 3, 2013): 24–29. http://dx.doi.org/10.3329/bmjk.v45i1-2.13626.

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The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, the second most common cause of primary amenorrhoea usually remains undetected until puberty and is characterized by congenital aplasia or hypoplasia of the uterus and most of the vagina in women showing normal secondary sexual characteristics. MRKH syndrome may be isolated (type I) but is more frequently associated with renal, vertebral, and, to a lesser extent, auditory and cardiac defects (MRKH type II or MURCS association). Complete evaluation of MRKH patient includes genital, urinary tract, cardiac, spinal and auditory assessment which need multidisciplinary approach. This review is an attempt to discuss the subtypes, associated anomalies, diagnostic consideration and treatment recommendations of patients with MRKH syndrome and aimed to make the specialists of other discipline, general physicians and the gynaecologists well aware about the entity. DOI: http://dx.doi.org/10.3329/bmjk.v45i1-2.13626 Bang Med J (Khulna) 2012; 45 : 24-29
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Krisna, Ratih, and Rizky Agustria. "Laparoscopic Davydov Procedure for Creation of Neovagina in MRKH Syndrome." Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, no. 3 (May 18, 2021): 809–13. http://dx.doi.org/10.32539/bsm.v5i3.348.

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Introduction: The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a condition in which there is an absence of the uterus and the upper part (2/3) of the vagina. Women with MRKH syndrome show normal development of secondary sexual characteristics and a normal 46, XX karyotype. MRKH syndrome is a common cause of primary amenorrhea. Ultrasonography examination confirms kidneys, presence of the ovaries, and absence of uterus. Treatment should include a multidisciplinary approach to create a functional vagina. One of the procedures is laparoscopic Davydov vaginoplasty. Aim: To report MRKH syndrome case treated with laparoscopic Davydov vaginoplasty. Method: Ms. A, 21 years old, P0A0, came to FER clinic Moh. Hoesin Hospital Palembang with complaint, never had menstruation, the patient admitted her breast, and her pubic had growth. She wants to get married in the next six months. From the US result, there was non visualized uterus, genital band (+), and both ovaries within normal limit ~ MRKH Syndrome. Karyotype Examination: 46, XX. Patient was diagnosed with primary amenorrhea caused by MRKH syndrome and was planned for neovagina (Davydov Procedure). Result: A woman 21-year-old, P0A0, was diagnosed with primary amenorrhea caused by MRKH syndrome. The Davydov procedure was done to create a neovagina. Intraoperative, after protrusion of the wood mold as a marker shown, an incision is made to the left and right side so that the mold penetrates the abdominal cavity, then the mold is pulled into the vaginal canal slowly. The anterior and posterior peritoneal layers are drawn into the vaginal canal. The anterior and posterior peritoneal layers were withdrawn with an ovum clamp and then interrupted suture. The anterior and posterior peritoneal layers were sutured in a circular method to form a vaginal cuff. The vaginal wall is sutured (interrupted) to hold mold fixed. Conclusion: MRKH syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and the uterus to be underdeveloped or even absent at birth. Patients with diagnosed MRKH syndrome require interdisciplinary care. Davydov procedure is a laparoscopically-assisted technique, which has an advantage over traditional approaches. It has shorter operating time, lower intraoperative complications, shorter hospital stay, and no external scars. Postoperatively, sexual function is similar to women without gynecological disorders.
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Oppelt, Patricia G., Andreas Müller, Liana Stephan, Ralf Dittrich, Johannes Lermann, Christian Büttner, Arif B. Ekici, et al. "Hyperandrogenemia and high prolactin in congenital utero–vaginal aplasia patients." Reproduction 153, no. 5 (May 2017): 555–63. http://dx.doi.org/10.1530/rep-16-0408.

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Patients with the Mayer–Rokitansky–Küster–Hauser syndrome (MRKH) have a congenital utero–vaginal cervical aplasia, but normal or hypoplastic adnexa and develop with normal female phenotype. Some reports mostly demonstrated regular steroid hormone levels in small MRKH cohorts including single MRKH patients with hyperandrogenemia and a clinical presentationof hirsutism and acne has also been shown. Genetically a correlation of WNT4 mutations with singular MRKH patients and hyperandrogenemia was noted. This study analyzed the hormone status of 215 MRKH patients by determining the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, 17-OH progesterone, testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone–binding globulin (SHBG) and prolactin to determine the incidence of hyperandrogenemia and hyperprolactinemia in MRKH patients. Additional calculations and a ratio of free androgen index and biologically active testosterone revealed a hyperandrogenemia rate of 48.3%, hyperprolactinemia of 9.8% and combined hyperandrogenemia and hyperprolactinemia of 4.2% in MRKH patients. The rates of hirsutism, acne and especially polycystic ovary syndrome (PCOS) were in the normal range of the population and showed no correlation with hyperandrogenemia. A weekly hormone assessment over 30 days comparing 5 controls and 7 MRKH patients revealed high androgen and prolactin, but lower LH/FSH and SHBG levels with MRKH patients. The sequencing of WNT4, WNT5A, WNT7A and WNT9B demonstrated no significant mutations correlating with hyperandrogenemia. Taken together, this study shows that over 52% of MRKH patients have hyperandrogenemia without clinical presentation and 14% hyperprolactinemia, which appeals for general hormone assessment and adjustments of MRKH patients.
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Adamiak-Godlewska, Aneta, Katarzyna Skorupska, Tomasz Rechberger, Katarzyna Romanek-Piva, and Paweł Miotła. "Urogynecological and Sexual Functions after Vecchietti Reconstructive Surgery." BioMed Research International 2019 (February 25, 2019): 1–4. http://dx.doi.org/10.1155/2019/2360185.

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Hypothesis/Aims of Study. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is the second most common cause of primary amenorrhea. The ESHRE/ESGE categorizes this disorder within the class 5 uterine malformation of the female genital tract anomalies. It is characterized by congenital absence of the uterus, cervix, and upper part of the vagina in otherwise phenotypically normal 46XX females. These patients have normal ovaries, biphasic ovarian cycle, and female psychosexual identification. Laparoscopic Vecchietti’s operation—surgical method in which the vagina increases in size by gradually applying traction to the vaginal vault—is one of the methods used to treat MRKH. The aim of this study was to establish the urogynecological and sexual functions after Vecchietti’s operation. Study Design, Materials and Methods. Fifteen patients with MRKHS who underwent laparoscopic Vecchietti’s operation were included. A control group of 15 age-matched, childless, sexually active women were examined during the same period. All patients underwent the basic evaluation of anatomical outcomes. Sexual outcomes were established by the Polish validated Female Sexual Function Index (FSFI) questionnaire. Continence status was assessed by Polish validated Urinary Distress Inventory (UDI-6) and the Incontinence Impact Questionnaire (IIQ-7). Results. Mean age of MRKH group was 22.06±5.13 yrs. Mean follow-up after surgery was 8.02±3.43 yrs. Mean age of women from control group was 22.4±4.35. Mean FSFI scores show good quality of sexual life in both groups. UDI-6 scores showed that patients after Vecchietti surgery have urogynecological problems significantly more often than healthy women do. Based on the IIQ-7, it is evident that one patient from the MRKH group (6,6%) suffers from stress urinary incontinence and the rest (20%) have rather irritative problems with the functioning of the lower urinary tract. Conclusion. Quality of sexual life after the Vecchietti’s operation in long-term follow-up does not differ from that of healthy women, but these patients suffer more frequent from urogynecological complaints. The trial is registered with NCT03809819.
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Tavera, Gloria, and Rina Lazebnik. "Müllerian Agenesis Masquerading as Secondary Amenorrhea." Case Reports in Pediatrics 2018 (July 19, 2018): 1–3. http://dx.doi.org/10.1155/2018/6912351.

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The most common cause of primary amenorrhea is congenital malformation of the Müllerian ducts, including Müllerian agenesis, also known as Mayer–Rokitansky–Küster–Hauser syndrome (MRKH). Most general gynecologists and primary care physicians who see female adolescents will encounter MRKH in their careers. We present the case of an adolescent with MRKH who reported secondary, instead of primary amenorrhea. We discuss the subtleties of diagnosing MRKH, especially when patient history may not always be accurate. Because MRKH had not been included in the differential diagnosis for delayed menses, this patient was initially misdiagnosed. Delayed diagnosis of MRKH may harm patients by delaying assessment of concomitant renal, skeletal, hearing, and cardiac defects, which might otherwise impact the treatment plan.
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Dissertations / Theses on the topic "MRKH syndrom"

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Frank, Liliane Theresa [Verfasser], and Sara [Akademischer Betreuer] Brucker. "Mutationsanalyse von OXTR und ESR1 bei Patientinnen mit MRKH-Syndrom / Liliane Theresa Frank ; Betreuer: Sara Brucker." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199545880/34.

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Bungartz, Jessica [Verfasser], and Sara [Akademischer Betreuer] Brucker. "Das MRKH-Syndrom : Klinik, Analyse der Fehldiagnosen und Entwicklung eines Leitfadens zur Differenzialdiagnostik und zur Vermeidung von „Malpractice“ / Jessica Bungartz ; Betreuer: Sara Brucker." Tübingen : Universitätsbibliothek Tübingen, 2012. http://d-nb.info/1161735364/34.

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König, Juliana Leonie Berit [Verfasser], and Sara Yvonne [Akademischer Betreuer] Brucker. "Analyse der Funktionalität von Hormonrezeptoren und der HOXA10-Expression endometrialer Stromazellen zur Ursachenforschung bei Patientinnen mit MRKH-Syndrom / Juliana Leonie Berit König ; Betreuer: Sara Yvonne Brucker." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615196/34.

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König, Juliana [Verfasser], and Sara Yvonne [Akademischer Betreuer] Brucker. "Analyse der Funktionalität von Hormonrezeptoren und der HOXA10-Expression endometrialer Stromazellen zur Ursachenforschung bei Patientinnen mit MRKH-Syndrom / Juliana Leonie Berit König ; Betreuer: Sara Yvonne Brucker." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199615196/34.

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Shy, Hannah Marie. "Mayer-Rokitansky-Kuster-Hauser Syndrome." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/612432.

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Mayer-Rokitansky-Kuster-Hauser Syndrome is a congenital disorder of the female reproductive tract due to impaired Müllerian duct development. There are three known categorical presentations: isolated, atypical, and MURCS association. Several developmentally significant factors including inappropriate AMH/AMHR interaction, and mutations in the WNT gene family and HOXA7-13 cluster have been studied. There has also been investigation into an autosomal dominant pattern of inheritance in families with multiple cases of the syndrome. Due to the presence of multiple subsets of patients with similar genetic abnormalities, it seems unlikely that a single etiology will be discovered.
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Guntram, Lisa. "Ambivalent Ambiguity? : A study of how women with 'atypical' sex development make sense of female embodiment." Doctoral thesis, Linköpings universitet, Tema teknik och social förändring, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111100.

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Against a backdrop of feminist and social scientific research on sex, female embodiment, and normality this thesis aims to discern how young women, who in adolescence have learned that their bodies are developing in ways considered ‘atypical’ for the female sex, make sense of their bodies and their situation. In focus are the ways in which the women make sense of and negotiate female embodiment; how they, particularly in stories about their interactions with others, position their embodied selves; and how norms and beliefs about sexed embodiment, heterosexual practice, and in/fertility are strengthened and challenged in the interviewees’ sense-making. The data comprise 23 in-depth interviews with women who in adolescence have learned that they do not have a uterus and a vagina, or who have learned that they do not have two X chromosomes and have no, or non-functioning, ovaries. Through narrative and thematic analysis the thesis shows how the women’s sense-making can be obstructed by norms about female embodiment, heterosexual practice, and in/fertility, expressed through medical terminology and practice and in interaction with family, friends, and peers, as described by the interviewees. Concomitantly, as the thesis demonstrates, medical terminology can be experienced and function as a resource in the women’s sense-making. Diagnostic categories enable them to put the specificities of sex development into words and raise awareness about bodily variation. Furthermore, in their stories about others’ reactions to their bodies and about their experience and management of certain medical treatments, the women question norms about female embodiment, heterosexual practice, and in/fertility that were previously taken for granted. The complexity of the women’s sense-making is demonstrated through the ways in which the interviewees, on the one hand, align with norms about female embodiment, heterosexual practice, and in/fertility, and in which they, on the other hand, succeed in challenging the same. In this ‘juggling’ of reinforcement and resistance, the thesis argues, the women are found to expand rather than dismiss beliefs about female embodiment.  Thus, the thesis contributes with deepened knowledge about what it can be like to live with these specific conditions and with problematizations of how norms about female embodiment can be enacted and questioned.
Mot bakgrund av feministisk och samhällsvetenskaplig forskning kring kön, kvinnlig kroppslighet och normalitet syftar avhandlingen till att undersöka hur unga kvinnor, som i tonåren fått reda på att deras kropp utvecklas på ett sätt som anses ”otypiskt” för det kvinnliga könet söker förstå och skapa mening kring sin kropp och situation. Framförallt undersöks dessa kvinnors meningsskapande, hur de i sina berättelser positionerar sig i relation till andra, och hur normer och föreställningar om kvinnlig kroppslighet, heterosexuell praktik och in/fertilitet förstås, förhandlas, stärks och ifrågasätts i berättelserna. Materialet som undersöks utgörs av 23 djupintervjuer med kvinnor som i tonåren fått reda på att de antingen inte har någon livmoder och vagina eller att de inte har två X kromosomer och inga eller  icke-fungerade äggstockar. Genom narrativa och tematiska analyser visar avhandlingen hur kvinnornas meningskapande formas av normer kring kvinnlig kroppslighet, heterosexuell praktik och in/fertilitet, då de uttrycks i kvinnornas berättelser om sin situation i möten med andra och i relation till medicinsk praktik. Samtidigt, visar avhandlingen, kan medicinsk terminologi, specifikt diagnoser, och praktik utgöra resurser i kvinnornas meningsskapande som möjliggör för dem att sätta ord på och sprida kunskap om kroppslig variation. I kvinnornas berättelser om andras reaktioner på deras kroppar och om deras erfarenhet och hantering av specifika medicinska behandlingar utmanas vidare normer som kvinnorna tidigare har tagit för givet. Genom analysen framträder således komplexiteten i kvinnornas meningskapande då de å ena sidan anammar förgivettagna normer om kvinnlig kroppslighet, heterosexuell praktik och infertilitet och å andra sidan utmanar de samma. I detta ”jonglerande” av anpassning till normer och motstånd mot desammasyns kvinnorna expandera snarare än avfärda föreställningar om kvinnlig kroppslighet. Avhandlingen fördjupar därmed kunskapen om hur det kan vara att leva med dess specifika tillstånd och till att problematisera hur normer om kvinnlig kroppslighet kan ta sig uttryck och ifrågasättas.
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Espie, Carolyn. "Exploring the short term psychological impact of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome for young women : an interpretational phenomenological analysis approach." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3638/.

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Background: MRKH is a congenital condition which renders women unable to menstruate, carry a child, or have sexual intercourse (Edmonds, 2000). However, there is a scarcity of research regarding the psychological impact of the condition. Diagnosis is made in mid to late adolescence, a time where social relationships and identity are salient, hence there may be specific challenges at this point and through the transition to adulthood. Aims: The study aimed to explore the impact of MRKH on young women. Methods: Five women (aged 18 to 22) diagnosed within the past five years took part in a non-directive semi-structured interview. Transcripts were analysed using Interpretative Phenomenological Analysis. Results: Four themes were identified; hindering independence, a sensitivity to difference, managing intimacy and managing threat to identity. The personal and sensitive nature of MRKH had a significant social impact for the young women’s developing identity, autonomy, and negotiation of peer and sexual relationships. Fear of being stigmatised caused them to manage their presentation to others in order to minimise the impact of their diagnosis. Conclusions: The study offered a unique insight into the social challenges of MRKH in the transition to adulthood. Implications for services and future research directions are indicated.
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Henckes, Nicole Andrea Corbellini. "Interação entre células e biomateriaispara desenvolvimento de neovagina : ensaios in vitro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/179688.

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A síndrome de Mayer-Rokitansky-Kuster-Hauser (MRKH) caracteriza-se pela aplasia congênita dos ductos Mullerianos. Devido a algumas características peculiares, as células-tronco mesenquimais estão sendo vistas como uma nova alternativa de tratamento em pacientes acometidos pela síndrome de MRKH. Considerando que alguns biomateriais servem como suporte estrutural e interferem positivamente na regeneração tecidual, a associação da linhagem celular de mucosa vaginal HMV-II e das MSC derivadas de tecido adiposo humano com biomateriais apresenta uma nova possibilidade na criação de neovagina. Nesta perspectiva, foram cultivadas células HMV-II com diferentes biomateriais (Membracel, Biofilme, Cellprene, PLGA PI quimicamente modificado) a fim de selecionar o melhor material alternativo. Ambas as células, associadas ao biomaterial selecionado, foram submetidas à análise morfológica, coloração ácido periódico-Schiff (PAS), expressão de marcadores epiteliais específicos por imunofluorescência e microcopia eletrônica de varredura (MEV). As células que interagiram com o biomaterial apresentaram marcadores epiteliais específicos e características morfológicas epiteliais. Estes resultados indicam que a interação do biomaterial com ambas as células testadas tem potencial capacidade para uma epitelização eficiente da neovagina. O crescimento das MSC com o biomaterial selecionado para implantação subsequente em pacientes com síndrome de MRKH pode representar uma alternativa válida e promissora para a reconstrução vaginal.
The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the Mullerian ducts. Because mesenchymal stem cells (MSCs) secrete paracrine factors, they have been seen as a new treatment option for several diseases. Considering that some biomaterials can be used as scaffolds and interfere positively in tissue regeneration, the association of human vaginal mucosa (HMV-II) cell line and MSCs with biomaterials appears as a new option for the creation of neovagina. In this study we cultured HMV-II cells with different biomaterials (Membracel, Biofilm, Cellprene, chemically modified PLGA PI) to select the best alternative material. For that both cells were cultured with the selected biomaterial and evaluated by morphological analysis, periodic acid-Schiff (PAS) staining, expression of epithelial markers by immunofluorescence and scanning electron microscopy (SEM). The analysis of the in vitro cell-biomaterial interactions showed specific epithelial markers and epithelial morphological features for both cells. These results indicate that the interaction of the biomaterial with the two tested cells has the potential capacity for an efficient epithelialization of the neovagina. Therefore, growth of MSCs with the selected biomaterial for subsequent implantation in patients with MRKH syndrome may represent a valid and promising alternative for vaginal reconstruction.
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Book chapters on the topic "MRKH syndrom"

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Altchek, Albert. "Congenital Gynecologic Anomalies I - Rokitansky Syndrome (MRKH Syndrome)." In Pediatric, Adolescent, & Young Adult Gynecology, 215–30. Oxford, UK: Wiley-Blackwell, 2009. http://dx.doi.org/10.1002/9781444311662.ch24.

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Jain, Nidhi, and Jyotsna Harlalka Kamra. "A Review of Literature on Mrkh Syndrome." In New Frontiers in Medicine and Medical Research Vol. 1, 119–29. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/nfmmr/v1/2980f.

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Kim, HG, R. Ullmann, Y. Shen, LP Chorich, JF Gusella, HH Ropers, V. Kalscheuer, RH Reindollar, and LC Layman. "Mapping a Causative Gene in Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome in a Balanced 46, XX, T(3;16)(p21;p13.3)." In The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego, P1–308—P1–308. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part1.p7.p1-308.

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Conference papers on the topic "MRKH syndrom"

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Ratnawati, Retty, and Gardha Arsy. "Teens dealing with MRKH syndrome to achieve self-actualization: is it unequal gender decision?" In Proceedings of the 3rd International Conference on Gender Equality and Ecological Justice, GE2J 2019, 10-11 July 2019, Semarang, Indonesia. EAI, 2020. http://dx.doi.org/10.4108/eai.10-7-2019.2299663.

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