Academic literature on the topic 'MS 2020'

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Journal articles on the topic "MS 2020"

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Wendel, Monica, James N. Burdine, Heather Clark, E. Lisako Jones McKyer, and Rae Lynn Mitchell. "Kenneth R. McLeroy, PhD, MS (1947–2020)." Health Education & Behavior 47, no. 6 (2020): 927–28. http://dx.doi.org/10.1177/1090198120964204.

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Shen, Xiuwei, Jianshe Ma, Xianqin Wang, Congcong Wen, and Meiling Zhang. "Toxicokinetics of 11 Gelsemium Alkaloids in Rats by UPLC-MS/MS." BioMed Research International 2020 (July 15, 2020): 1–13. http://dx.doi.org/10.1155/2020/8247270.

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Gelsemium elegans (Gardn. & Champ.) Benth. is a plant belonging to the genus Gelsemium (family Gelsemiaceae), and its main components are alkaloids. It is a Chinese traditional medicinal plant and notoriously known as a highly toxic medicine. However, a method has not yet been found for the simultaneous detection of 11 Gelsemium alkaloids in rat plasma, and the toxicokinetics of 11 Gelsemium alkaloids after intravenous administration has not been reported. In this work, we have developed a sensitive and rapid method of ultraperformance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) for the detection of 11 Gelsemium alkaloids in rat plasma. The toxicokinetic behavior was also investigated, so as to provide a reference of the scientific properties of Gelsemium elegans and improve the efficacy and safety of drugs. Sixty-six Sprague-Dawley rats were randomly divided into 11 groups, six rats in each group. Each group was intravenously given one alkaloid (0.1 mg/kg), respectively. A Waters UPLC BEH C18 column (50 mm×2.1 mm, 1.7 μm) was used for chromatographic separation. Methanol and water (containing 0.1% formic acid) were used for the mobile phase with gradient elution. Multiple reactions were monitored, and positive electrospray ionization was used for quantitative analysis. The precision was less than 16%, and the accuracy was between 86.9% and 113.2%. The extraction efficiency was better than 75.8%, and the matrix effects ranged from 88.5% to 107.8%. The calibration curves were in the range of 0.1–200 ng/mL, with a correlation coefficient (R2) greater than 0.995. The UPLC-MS/MS method was successfully applied to the toxicokinetics of 11 Gelsemium alkaloids in rats after intravenous administration (0.1 mg/kg for each alkaloid). The results of the toxicokinetics provide a basis for the pharmacology and toxicology of Gelsemium alkaloids and scientific evidence for the clinical use of Gelsemium alkaloids.
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Qiao, Ming, Jianhua Yang, Yao Zhao, et al. "Antiliver Fibrosis Screening of Active Ingredients from Apium graveolens L. Seeds via GC-TOF-MS and UHPLC-MS/MS." Evidence-Based Complementary and Alternative Medicine 2020 (February 19, 2020): 1–12. http://dx.doi.org/10.1155/2020/8321732.

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Although several studies have been performed on Apium graveolens L.(celery) seeds, their antiliver fibrosis effects remain to be unexplored. Firstly, we detected the effects of celery seeds extracted with different concentrations of aqueous ethanol on the proliferation of HSC-LX2 cells. Then, we detected the effects of fractions of the optimal effect extract on the proliferation and apoptosis of HSC-LX2 cells. Finally, the compounds of petroleum ether (PP), ethyl acetate (PE), n-butyl alcohol (PB), and water fractions (PW) of the optimal effect extract were determined by GC-TOF-MS and UHPLC-MS/MS, to confirm the potentially antifibrotic compounds combined with pharmacodynamic experiment of monomer compounds in vitro. The results revealed that 60% ethanol extract of celery seeds (60-extract) exhibited remarkable inhibition effect on the proliferation of HSC-LX2 cells compared with 95% ethanol and aqueous extract. Besides, it validated that the inhibition rates of PP, PE, PB, and PW on the proliferation of HSC-LX2 cells were 75.14%, 73.52%, 54.09%, and 43.36%, and their percentage of apoptotic cells were 37.5%, 4.3%, 0.7%, and 0.1% at high doses, respectively. Additionally, it was manifested that apigenin, aesculetin, and butylphthalide have major contribution to the overall compounds of celery seeds, and the inhibition effects on the cell proliferation clearly elevated with increase in their contents. In essence, apigenin, aesculetin, and butylphthalide may hopefully become the natural products of antiliver fibrosis, which laid a foundation for the subsequent development of celery seeds as antiliver fibrosis drugs.
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Stone, Amy E. S., Gary O. Brummet, Ellen M. Carozza, et al. "2020 AAHA/AAFP Feline Vaccination Guidelines*." Journal of the American Animal Hospital Association 56, no. 5 (2020): 249–65. http://dx.doi.org/10.5326/jaaha-ms-7123.

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ABSTRACT The guidelines are a consensus report on current recommendations for vaccination of cats of any origin, authored by a Task Force of experts. The guidelines are published simultaneously in the Journal of Feline Medicine and Surgery (volume 22, issue 9, pages 813–830, DOI: 10.1177/1098612X20941784) and the Journal of the American Animal Hospital Association (volume 56, issue 4, pages 249–265, DOI: 10.5326/JAAHA-MS-7123). The guidelines assign approved feline vaccines to core (recommended for all cats) and non-core (recommended based on an individualized risk-benefit assessment) categories. Practitioners can develop individualized vaccination protocols consisting of core vaccines and non-core vaccines based on exposure and susceptibility risk as defined by the patient’s life stage, lifestyle, and place of origin and by environmental and epidemiologic factors. An update on feline injection-site sarcomas indicates that occurrence of this sequela remains infrequent and idiosyncratic. Staff education initiatives should enable the veterinary practice team to be proficient in advising clients on proper vaccination practices and compliance. Vaccination is a component of a preventive healthcare plan. The vaccination visit should always include a thorough physical exam and client education dialog that gives the pet owner an understanding of how clinical staff assess disease risk and propose recommendations that help ensure an enduring owner-pet relationship.
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Caporuscio, Christian, Derek Holmes, Timothy V. Olah, and Petia Shipkova. "Immunoaffinity enrichment LC–MS/MS quantitation of CDH17 in tissues." Bioanalysis 12, no. 20 (2020): 1439–47. http://dx.doi.org/10.4155/bio-2020-0162.

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Aim: There is little information in the literature regarding assays for measuring CDH17 in tissues. Numerous studies indicate overexpression of CDH17 in a variety of diseases including hepatocellular carcinoma, colorectal and gastric cancer. Here we present an immunoaffinity enrichment LC–MS/MS approach for analysis of CDH17 in human tissues, plasma and serum as well as preclinical models. Results: CDH17 levels were measured in colon and ileum tissues from healthy donors and inflamed tissues from patients with Ulcerative Colitus or Crohn’s disease. Applicability of the immunocapture LC–MS/MS approach is demonstrated for colon tissues from non-diseased mouse and cynomolgus monkey. Conclusion: The analytical approaches discussed here are suitable for quantitation of CDH17 in various tissues to enable both preclinical and clinical assessment.
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Coetzee, Timothy, and Alan J. Thompson. "Atlas of MS 2020: Informing global policy change." Multiple Sclerosis Journal 26, no. 14 (2020): 1807–8. http://dx.doi.org/10.1177/1352458520968811.

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Ashwood, Christopher, Wout Bittremieux, Eric W. Deutsch, et al. "Proceedings of the EuBIC-MS 2020 Developers’ Meeting." EuPA Open Proteomics 24 (December 2020): 1–6. http://dx.doi.org/10.1016/j.euprot.2020.11.001.

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Qasem, Rani J., Ibrahim K. Frah, Ahmad S. Aljada, and Faisal A. Sehli. "Bioanalysis of plasma acetate levels without derivatization by LC–MS/MS." Bioanalysis 13, no. 5 (2021): 373–86. http://dx.doi.org/10.4155/bio-2020-0294.

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Background: The acetate ion has important physiological functions and important therapeutic applications. A rapid LC–MS/MS method is described to measure acetate ions in human plasma without chemical derivatization. Materials & methods: A 200 μl sample was spiked with the internal standard 1,2-13C-acetate and proteins precipitated with trichloroacetic acid. The supernatant was recovered and separated under acidic conditions on a C18-column. The eluent was alkalinized by post-column infusion of methanolic ammonium hydroxide. Acetate ions were monitored on a low resolution mass spectrometer in negative ion mode. Results: Method was validated for accuracy and precision with a lower limit of quantitation of 9.7 μM and linear dynamic range up to 339.6 μM. Conclusion: The method is open for analytical improvement and adapts with metabolomic and pharmacometabolomic studies on chemicals of similar nature.
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Xu, Dan, Gui-Qiu Zhang, Ting-Ting Zhang, Bo Jin, and Chen Ma. "Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS." Journal of Analytical Methods in Chemistry 2020 (April 1, 2020): 1–10. http://dx.doi.org/10.1155/2020/8364218.

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Naringenin (NAR), 4′,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability. The pharmacokinetics and bioavailability of naringenin-nicotinamide cocrystal (NAR-NCT), which offers improved solubility, were evaluated in this study. Rats were orally administered NAR, a physical mixture of naringenin and nicotinamide (NAR + NCT), and NAR-NCT. The relative bioavailability of NAR-NCT was 175.09% of NAR, Cmax was 8.43 and 2.06 times of NAR and NAR + NCT, respectively, Tmax was advanced from 0.49 h to 0.09 h, CL was decreased from 91.1 L/h/kg to 49.1 L/h/kg, and t1/2 was increased from 5.37 h to 8.24 h, highlighting its rapid absorption and slow elimination. This study showed that NAR-NCT could improve the bioavailability of NAR.
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Wang, Bo, Feifei Chen, Quan Zhou, et al. "Pharmacokinetics of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, in Rats by UPLC-MS/MS." International Journal of Analytical Chemistry 2020 (May 30, 2020): 1–6. http://dx.doi.org/10.1155/2020/7290470.

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Lusutrombopag is a second oral thrombopoietin (TPO) receptor agonist that selectively acts on human TPO receptors. In the study, UPLC-MS/MS was used to establish a selective and sensitive method to determine lusutrombopag with poziotinib as IS (internal standard) in rat plasma. Samples were prepared by precipitating protein with acetonitrile as a precipitant. Separation of lusutrombopag and poziotinib was performed on a CORTECS UPLC C18 column (2.1 ∗ 50 mm, 1.6 μm). The mobile phase (acetonitrile and water containing 0.1% formic acid) with gradient elution was set at a flow rate of 0.4 ml/min. The mass spectrometric measurement was conducted under positive ion mode using multiple reaction monitoring (MRM) of m/z 592.97 ⟶ 491.02 for lusutrombopag and m/z for poziotinib (IS) 492.06 ⟶ 354.55. The linear calibration curve of the concentration range was 2–2000 ng/ml for lusutrombopag, with a lower limit of quantification (LLOQ) of 2 ng/ml. RSD of interday and intraday precision were both no more than 9.66% with the accuracy ranging from 105.82% to 108.27%. The extraction recovery of lusutrombopag was between 82.15% and 90.34%. The developed and validated method was perfectly used in the pharmacokinetic study of lusutrombopag after oral administration in rats.
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Dissertations / Theses on the topic "MS 2020"

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Stemmerich, Karsten Verfasser], Karin [Akademischer Betreuer] [Schwarz та Andreas [Gutachter] Koch. "Selektive Bestimmung von IPG F2α mittels LC-DMS-MS/MS in Urin von Tauchern vor und nach einer Sauerstoffbelastung durch Tauchgänge / Karsten Stemmerich ; Gutachter: Andreas Koch ; Betreuer: Karin Schwarz". Kiel : Universitätsbibliothek Kiel, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:8-mods-2020-00134-3.

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Jantos, Anne. "Conducting Oral Examinations Virtually using MS Teams: An Insightful Experience Report." TUDpress, 2020. https://tud.qucosa.de/id/qucosa%3A73902.

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This article describes the planning, the procedure, any complications, opportunities, and limitations within an analysis of the meetings and with the help of interviews of the examinees as well as the examiner and the recording clerk and thus shows a first-hand experience report which is decisive for the future. For this purpose, a list of reflections will be created, which can be used to prepare similar exams. This list will be structured in didactics, information technology, organisation, and preparation and examination regulations. Building on that, we created a timeline with a corresponding check list of actions and considerations which can be used in similar cases.
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Gülzau, Fabian. "Cultural Patterns in Parenting." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20119.

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Die vorliegende Arbeit untersucht kulturelle Vorstellungen und Praktiken von Elternschaft in Deutschland. Wie Familien ihre Kinder erziehen ruft ein steigendes Interesse von Seiten der Politik, Wissenschaft und weiterer (Bildungs-)Professionen hervor. Gegenwärtig wird von Eltern erwartet, dass sie sich mit Expertenwissen auseinandersetzen, welches oftmals kostspielige und zeitaufwändige Praktiken nahelegt. Zur gleichen Zeit nehmen staatliche Akteure verstärkt Einfluss auf das familiale Leben und insbesondere die Kindererziehung. Als Folge dieser Entwicklung haben sich die kulturellen Vorstellungen von Elternschaft in Deutschland gewandelt. Mit diesen Entwicklungen beschäftigt sich die vorliegende Arbeit in drei Aufsätzen. Im Einzelnen betrachten die Artikel: (1) die Bedingungen von familienpolitischen Reformen, (2) die elterlichen Diskussionen um sich wandelnde Erwartungen sowie (3) die Auswirkung der elterlichen Klassenposition auf deren Erziehungspraktiken. Um diese Fragen zu beantworten greifen die Artikel sowohl auf Umfragedaten als auch digitale Daten zurück, die mit neuen Methoden der computergestützten Sozialforschung analysiert werden. Insgesamt erweitert die vorliegende Dissertation unser Wissen um den aktuellen Wandel von Elternschaft in Deutschland. Zudem werden innovative Methoden der computergestützten Sozialforschung in die Familiensoziologie eingeführt. Zuletzt wurde mit kulturellen Leitbildern von Elternschaft ein Zugang vorgeschlagen, der es erlaubt den gegenwärtigen Wandel von Elternschaft zu untersuchen.<br>The thesis at hand investigates conceptions and practices of parenthood in Germany. How families approach their childrearing has attracted growing interest in politics, science, and by (education) professionals. Today, parents are encouraged to seek expert advice to inform their childrearing. Such advice often involves the expenditure of considerable amounts of time and money. At the same time, the state has become increasingly active in the intimate life of families and, in particular, their parenting practices. As a result, the cultural models of parenthood in Germany have been changed. At the background of these changes, I designed three papers that analyze (1) the conditions of family policy change, (2) the way parents adopt changing expectations and demands, and (3) the relationship between parenting practices and social class. In order to address these questions, the respective articles use survey and digital data as well as methods from the computational social sciences (CSS). In sum, the dissertation expands our knowledge on the current recalibration of parenthood in Germany. It also introduces innovative methods from CSS to family sociology. Finally, cultural models of parenthood are proposed as a way to organize the research on changing standards and norms of parenthood.
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Öberg, Tomas. "Design av databassystem för testresultat från Tor-systemet." Thesis, Linköping University, Department of Computer and Information Science, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2291.

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<p>This master’s thesis was performed at PartnerTech AB in Åtvidaberg. It addresses the problem of managing test results obtained from testing electronics manufactured by PartnerTech. PartnerTech has developed a test system, called Tor, which performs tests on manufactured boards and stores the test results in files. The Tor system consists of both hardware and software part, where the software runs on an ordinary PC with MS DOS/Windows 2000. The effects on the existing Tor system that this thesis implies are minimal. </p><p>This work focuses on a way of storing the produced test files in a database. In this work a data model has been developed, implemented, and evaluated together with a system that imports test files into the database and a graphical user interface that allows a user to easily search and browse the stored test results. It is also possible to print test reports from the Tor system. For implementing the database system Microsoft SQL Server 2000 was chosen as database server and an XML based data format was chosen to import and export data to and from the database. Two alternative graphical user interface applications were developed and compared - one server based on Microsoft IIS and one client based in Microsoft Access. For advanced data manipulation certain parts of the system were developed in Microsoft Excel.</p>
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Figueira, Kátia Cristina Nascimento. "Forças armadas e educação : o Colégio Militar de Campo Grande – MS (1993-2010)." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/7280.

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Submitted by Caroline Periotto (carol@ufscar.br) on 2016-09-20T13:00:53Z No. of bitstreams: 1 TeseKCNF.pdf: 4541813 bytes, checksum: 014c92a82ad87ff3acacace3bf6e326d (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-09-20T18:05:53Z (GMT) No. of bitstreams: 1 TeseKCNF.pdf: 4541813 bytes, checksum: 014c92a82ad87ff3acacace3bf6e326d (MD5)<br>Approved for entry into archive by Marina Freitas (marinapf@ufscar.br) on 2016-09-20T18:06:02Z (GMT) No. of bitstreams: 1 TeseKCNF.pdf: 4541813 bytes, checksum: 014c92a82ad87ff3acacace3bf6e326d (MD5)<br>Made available in DSpace on 2016-09-20T18:06:12Z (GMT). No. of bitstreams: 1 TeseKCNF.pdf: 4541813 bytes, checksum: 014c92a82ad87ff3acacace3bf6e326d (MD5) Previous issue date: 2011-06-27<br>Não recebi financiamento<br>This research work has as its object of study the relationship established between the Colégio Militar de Campo Grande, created in 1993, and the historical context in South mato-grossense ensues with the end of the cold war (1947-1991). To do so, establishes the links between the armed forces and their occupation geopolitics in Mato Grosso do Sul, the significance of this presence to the social organization of sul-mato-grossenses, power relations, the formation processes of teaching and how these elements materialize in the Colégio Militar de Campo Grande, Mato Grosso do Sul, in the field of history of School Institutions. The assumption that its creation during the last decade of the 20th century correlates with the formation of a new role as established by the armed forces after the military Government (1964-1985). The occupation of the southern territory of Mato Grosso, particularly after the war of Paraguay (1865-1870), was always associated with the issue of security and defence policy of intensifying national military presence in the State of Mato Grosso uno with the installation of the 9th military region of the army in 1921, in the city of Campo Grande. We reviewed the Constitution of the professionalization of the military in the new State and its alignment to North American geopolitics after World War II through the development of the national security doctrine by Escola Superior de Guerra. Thus, the hypothesis that guides our research part of the understanding that the presence of the armed forces in the South of Mato Grosso and Mato Grosso do Sul, until 1988, was linked to the geopolitical conception of capitalist occupation of territory and at the same time, the protection of cultural and political values of the so-called "Western Christian civilization." Thus, after the end of military dictatorship (1985) and the so-called "real socialism" (1991) the Brazilian military strategy has changed as a result of the new role assigned to the armed forces, whose traces can be observed in the creation of the Colegio Militar de Campo Grande. This College stands out from other public high schools in the State in the face of your infrastructure, your organization and your defense of hierarchy and discipline seated moral principles advocated by Émile Durkheim. In summary, we seek to answer the following questions: as if built historically the presence of military in Mato Grosso do Sul? How the internals of the College expressing the strategy adopted by the armed forces in this new role? What are the constituent elements of the school? The sources used were obtained through interviews and questionnaires, semistructured documents and bibliographies in both physical and virtual support. The basic theory analysis based explanatory theoretical Gramscian stance.<br>O presente trabalho de pesquisa tem como objeto de estudo a relação que se estabeleceu entre o Colégio Militar de Campo Grande, criado em 1993, e o contexto histórico sul-matogrossense advindo com o fim da Guerra Fria (1947-1991). Para tanto, estabelece os nexos entre as Forças Armadas e sua ocupação geopolítica em Mato Grosso do Sul, o significado dessa presença para a organização social dos sul-mato-grossenses, as relações de poder presentes, os processos de formação de ensino e como estes elementos se materializam no Colégio Militar de Campo Grande – Mato Grosso do Sul, inserindo-se no campo da História das Instituições Escolares. Partimos do pressuposto de que a sua criação durante a última década do século XX correlaciona-se com a constituição de um novo papel estabelecido pelas Forças Armadas após os governos militares (1964-1985). A ocupação do território sulista de Mato Grosso, particularmente após a Guerra do Paraguai (1865-1870), sempre esteve associado à questão da política de defesa e segurança nacional intensificando a presença dos militares no estado do Mato Grosso uno com a instalação da 9ª Região Militar do Exército, em 1921, na cidade de Campo Grande. Analisamos a constituição da profissionalização dos militares no Estado Novo e seu alinhamento a geopolítica norte- americana após a II Guerra Mundial por meio do desenvolvimento da Doutrina de Segurança Nacional pela Escola Superior de Guerra. Desta forma, a hipótese que norteia a nossa investigação parte da compreensão de que a presença das Forças Armadas no sul de Mato Grosso e Mato Grosso do Sul, até 1988, estava ligada à concepção geopolítica de ocupação capitalista do território e, ao mesmo tempo, à defesa dos valores culturais e políticos da chamada ―civilização ocidental cristã‖. Assim, após o fim da ditadura militar (1985) e do chamado ―socialismo real‖ (1991) a estratégia dos militares brasileiros mudou em decorrência do novo papel que foi atribuído às Forças Armadas, cujos traços podem ser observados na criação do Colégio Militar de Campo Grande. Este Colégio destaca-se de outros colégios públicos do Estado em face de sua infraestrutura, organização e de sua defesa da hierarquia e disciplina assentada nos princípios da moral preconizada por Émile Durkheim. Em síntese, buscamos responder as seguintes questões: como se construiu historicamente a presença dos militares em Mato Grosso do Sul? Como os elementos internos do colégio expressam a estratégia adotada pelas Forças Armadas nesse novo papel? Quais são os elementos constitutivos da escola? As fontes utilizadas foram obtidas por meio de entrevistas e questionários semi-estruturados, dos documentos e bibliografias tanto em suporte físico quanto virtual. A análise privilegiou a teoria gramsciana como base teórica explicativa.
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McKinney, Mariah, Courtney Gail Troglin, Jessica Brooke Bouldin, Shannon Schreiner, Stacy D. Brown, and Brooks B. Pond. "Pharmacokinetics of Synthetic Cathinones Found in “Bath Salts” in Mouse Brain and Plasma Using High Pressure Liquid Chromatography – Tandem Mass Spectrometry." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/15.

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Approximately 10 years ago, “bath salts” were popularized as legal alternatives to the psychostimulants cocaine and the amphetamines, circumventing legislation with packages marked, “not for human consumption.” These products contained synthetic cathinones including 3,4-methylenedioxypyrovalerone (MDPV), 4-methylmethcathinone (mephedrone), and 3,4-methylenedioxymethcathinone (methylone). The synthetic cathinones have similar pharmacology to controlled psychostimulants, increasing levels of dopamine (DA) in the synaptic cleft, while also exhibiting similar psychoactive effects such as increased energy and euphoria. Additionally, adverse effects of “bath salts” are similar to controlled psychostimulants, such as chest pain, shortness of breath, and hallucinations. Most preclinical investigations have only assessed the effects of these synthetic cathinones independently; however, case reports and DEA studies indicate that “bath salts” contain mixtures of these substances. Therefore, in a recent study by our laboratory, we examined effects of individual versus combined exposure to MDPV, mephedrone, and methylone. Interestingly, an enhanced effect on the levels of DA in a number of brain regions was observed, as well as significant alterations in locomotor activity following co-exposure to the cathinones. Here, we examine if the enhanced effects of the drug combination are due to pharmacokinetic (PK) interactions. Many of the same cytochrome isoenzymes metabolize each of these 3 drugs; thus, it is probable that the drugs’ PK would differ when administered individually as compared to in combination. We hypothesized that combined exposure to MDPV, mephedrone, and methylone would result in increased total drug concentrations when compared to individual administration. Briefly, adolescent male Swiss-Webster mice were injected intraperitoneally with either 10 mg/kg MDPV, 10 mg/kg mephedrone, 10 mg/kg methylone, or 10 mg/kg combined MDPV, mephedrone, and methylone. Following injection, brains and plasma were collected at the following time points: 1, 10, 15, 30, 60, and 120 minutes. Drugs were extracted via solid-phase extraction, and concentrations were determined using a previously published high pressure-liquid chromatography tandem mass spectrometry method. All drugs quickly crossed the blood-brain barrier and entered the brain. PK data for methylone and mephedrone was consistent with our hypothesis. For methylone, the maximal concentration (Cmax) and the total drug exposure (as represented by the area under the curve (AUC)) were significantly higher when combined with mephedrone and MDPV in both matrices. For mephedrone, the Cmax was unchanged, but AUC in brain was increased when combined with the other two drugs. However, interestingly, for MDPV, the Cmax was unchanged, yet the AUC in brain was higher when MDPV was administered individually. These data provide insight into the consequences of co-exposure to synthetic cathinones in popular “bath salt” products.
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Chen, Ping. "Pharmacokinetic-Pharmacodynamic Studies Of 5-Azacytidine In Combination With Gti-2040." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1221854928.

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Mori, Hirotsugu. "Dinosaurian Faunas of the Cedar Mountain Formation and LA-ICP-MS Detrital Zircon Ages for Three Stratigraphic Sections." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2000.

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The Cedar Mountain Formation contains the most diverse record of Early Cretaceous dinosaurs in the western hemisphere. However, analyses of its faunas have been hindered because 1) most taxa are based on incomplete/fragmentary materials or incomplete descriptions, 2) most sites and some horizons preserve few taxa, and 3) the stratigraphy and geochronology are poorly understood. To help resolve these stratigraphic and correlation problems U-Pb LA-ICP-MS detrital zircon ages were obtained at significant sites and horizons. These dates indicate all sites at or near the base of the formation are no older than 122 to 124 Ma, thus all basal stratigraphic packages are time equivalent. Detrital zircons coarsely bracket the temporal span of the Ruby Ranch Member between about 115 Ma to 111 Ma while the base of the Mussentuchit Member is dated between 108 to 104 Ma and the top of the member is Cenomanian in age. Multivariate analyses utilizing Simpson and Raup-Crick similarity index and pair-group moving algorithms reveal that formationfs faunas fall into two groups. These groups are compared statistically with European, Asian, and Morrison faunas. Results indicate (1) that there is no close relationship between the Yellow Cat fauna and the Morrison Formation fauna and (2) corroborate long-standing hypotheses that the Yellow Cat fauna has European ties and the Mussentuchit fauna has Asian ties. Detrital zircon LA-ICP-MS U-Pb ages were used in this study to approximate the time of deposition of strata because volcanic ashes are rarely preserved in the formation. The ability to select the youngest crystals in a sample prior to applying analytical methods could substantially reduce the number of crystals and cost required to obtain these dates. To this end, the hypothesis that the most pristine, unabraded crystals should be younger than abraded crystals was tested by imaging detrital zircons via SEM, ranking the crystals by the degree of abrasion, and determining their ages. Results of this study partly corroborate the hypothesis in that there is a correlation between the degree of abrasion and ages – obviously abraded crystals are most likely the oldest while pristine to slightly abraded crystals are usually the youngest in a given sample.
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Mateu, Miriam Cristina Franco. "METAMORFOSES NO MUNDO TRABALHO: Caso do setor bancário em Dourados (1990/2000)." UNIVERSIDADE FEDERAL DA GRANDE DOURADOS, 2006. http://tede.ufgd.edu.br:8080/tede/handle/tede/224.

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Made available in DSpace on 2016-02-26T14:52:33Z (GMT). No. of bitstreams: 1 MiriamCristinFrancoMateu.pdf: 547507 bytes, checksum: 3234aeaa1dac1667f544e87a8d1d03ca (MD5) Previous issue date: 2006-04-05<br>The changes which occurred in the work world in the last decades of the 20th century provided the new relation between the capital and the work. Flexibility was imposed as a bigger production and profits by the companies. New management practices and as a result, new work habits shaped a new profile of worker, and the collaborators, who dedicate themselves to their company and many times make a patron-like rhetoric as it was their own voice, being alienated from their collective representative, the Labor Union. So, the labor union force went through a crisis of originality, mingled by this state of things and by internal disputes between the combative and liberal chains. The speech of negotiation, as the best judge and instrument of fight, was present in almost all the labor unions, even the more historically combative. The present work studied this process of metamorphosis in the work world and its implications to the bank sector, especially, in Dourados City, during the 1990 s. It is aimed to analyze the tendencies and practices that were consolidated in their locus and that transformed the way it worked and mainly the bank workers<br>As mudanças ocorridas no mundo do trabalho nas últimas décadas do século XX redimensionaram as relações entre o capital e o trabalho. A flexibilização se impôs como resposta a maior produção e lucratividade das empresas. Novas práticas de gerenciamento, e por sua vez, novos hábitos de trabalho moldaram um novo perfil de trabalhador, o colaborador, que veste a camisa de sua empresa e por vezes faz da retórica patronal sua própria voz, alheando-se de seu representante coletivo, o Sindicato. Assim, o sindicalismo passou por uma crise de legitimidade, fragilizado por este estado de coisas e por disputas internas entre correntes combativas e liberais. O discurso da negociação, como melhor árbitro e instrumento de luta, rondou quase a unanimidade dos sindicatos, até mesmo, os historicamente mais combativos. O presente trabalho estuda esse processo de metamorfose no mundo do trabalho e suas implicações no interior do setor bancário, especificamente, o alocado na cidade de Dourados, durante a década de 1990. Buscou analisar as tendências e práticas que se consolidam no seu lócus e transformaram seu funcionamento e, principalmente, o trabalhador bancário
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Oliveira, Priscilla Alexandrino de. "Leishmaniose visceral em pacientes infectados por HIVestudo de casos observados em Campo Grande, MS, 2000-2006." reponame:Repositório Institucional da FIOCRUZ, 2007. https://www.arca.fiocruz.br/handle/icict/13511.

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Made available in DSpace on 2016-04-04T12:45:12Z (GMT). No. of bitstreams: 2 pricilla_oliveira_ioc_dout_2007.pdf: 1378604 bytes, checksum: f0dbf6910f9fd7228967184a959a3bd6 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2007<br>Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil<br>expansão e a urbanização da leishmaniose visceral (LV) em Mato Grosso do Sul tornaram a doença um problema de saúde pública no Estado. Para conhecer o comportamento clínico e epidemiológico da LV em indivíduos infectados pelo HIV, foi estudada uma série de 23 casos atendidos em dois hospitais da capital, Campo Grande, região Centro-Oeste do Brasil, de janeiro de 2000 a dezembro de 2006. Foram incluídos os pacientes com resultado sorológico positivo para o HIV documentado no prontuário e cultura positiva para Leishmania sp. em aspirado de medula óssea. Oitenta e sete por cento dos pacientes eram do sexo masculino, com mediana de idade de 37 anos (variando de 21 a 56 anos) Todos os pacientes foram procedentes de Mato Grosso do Sul. 34,8% dos pacientes apresentavam o uso de drogas injetáveis como categoria de exposição para o HIV. A maioria dos pacientes apresentava imunodeficiência avançada, com 80% dos pacientes com contagem de linfócitos T CD4+ inferior a 200 células/mm3 (mediana - 44,5 células/mm3) durante o primeiro episódio de LV. Apesar deste fato, ambas as doenças foram diagnosticadas simultaneamente em 43% dos pacientes. Todos os pacientes infectados pelo HIV com LV apresentaram febre e 78% hepatoesplenomegalia. Os pacientes apresentaram graus variados de diminuição das células sangüíneas e de anormalidades bioquímicas A pesquisa direta de Leishmania sp. em aspirado de medula óssea demonstrou alta positividade (87%) nos pacientes estudados. Cinco pacientes foram tratados exclusivamente com antimoniato de meglumina, cinco pacientes exclusivamente com desoxicolato de Anfotericina B e doze pacientes foram tratados com ambas as terapias, por reação adversa ou falha ao antimoniato de meglumina. Uma a duas recidivas por paciente foram observadas em 56,7% dos casos. Somente um paciente foi a óbito em conseqüência da LV<br>The outspread and urbanization of visceral leishma niasis in Mato Grosso do Sul becoming the disease a public health problem in the state. To know the clinical and epidemiological characteristics of visceral leishmaniasis in HIV patients, a series of 23 patients attended in Campo Grande, center west region of Brazil, from 2000 to 2006, was studied. We selected the patients with HIV and bone marrow culture positive for leishmaniasis The medi an age of patients was 37 years (range 21*56), 87% were male, All the patients live d in Mato Grosso do Sul, 34.8 percent of patients had intravenous drug use as the ir HIV transmission category. The majority of patients had advanced HIV disease, 80 p ercent had CD4+T cells count less than 200 cells/mm 3 and a median of 44.5 cells/mm3 during the first ep isode of visceral leishmaniasis. Despite of this fact, both diseases were diagnosed at the same time in 43 percent of the patients. All HIV in fected patients with visceral leishmaniasis presented fever, 78 percent presented enlargement of the liver and spleen. The patients presented varying degrees of b lood cytopenias and biochemical abnormalities. Diagnosis was also achieved in 87% o f the patients with the detection of Leishmania amastigotes in Giemsa*stained smears from aspirate s of bone marrow Five patients were treated only with meglumine anti moniate, four patients were treated with only amphotericin B and twelve patient s were treated with both therapies. One or two relapses were seen in 56.7 pe rcent of patients. Only one patient died due to leishmaniosis
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Books on the topic "MS 2020"

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Гультяев, А. К. MS Project 2002. КОРОНА-принт, 2003.

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Waymire, Richard. MS SQL Server 2000. Markt und Technik, 2001.

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Гудзенчук, З. В. Приложения MS Office 97/2000. Маркетинг, 2001.

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Pyron, Tim. MS Project 2000: [schrittweiser Einstieg ins Projektmanagement ; Ressourcen effizient einsetzen ; mit verteilten Teams Aufgaben bearbeiten]. Markt-und-Technik-Verl., 2001.

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Soares, Kamila, and Rodrigo Camacho. As relações dialógicas estabelecidas entre a escola municipal Dr. José Garcia Neto e a comunidade rural do assentamento Palmeira Nioaque-MS. Editora Conhecimento Livre, 2020. http://dx.doi.org/10.37423/2020.edcl82.

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Bauder, Irene, and Jürgen Bär. Access 2002 und MS SQL Server 2000. Hanser Fachbuch, 2001.

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McKee, Ken. MS VISIO 2010. FastPencil, Inc., 2011.

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Lotia, Manahar, Pradeep Nair, and Payal Lotia. MS PowerPoint 2000. BPB Publications, 2003.

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Weixel, Suzanne. Learning MS Word 2002. Prentice Hall, 2002.

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MS Word 2000: Introduction. CourseWare Company, 1999.

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Book chapters on the topic "MS 2020"

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Williams-Harry, Michele. "Tips for Success in Industry for BS, MS, and PhD Chemists." In ACS Symposium Series. American Chemical Society, 2020. http://dx.doi.org/10.1021/bk-2020-1367.ch006.

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Yan, Xingang, Weiwen Jiang, Yiyu Shi, and Cheng Zhuo. "MS-NAS: Multi-scale Neural Architecture Search for Medical Image Segmentation." In Medical Image Computing and Computer Assisted Intervention – MICCAI 2020. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-59710-8_38.

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Buele, Jorge, José Varela-Aldás, Esteban X. Castellanos, Janio Jadán-Guerrero, and Jeneffer Barberán. "3D Object Reconstruction Using Concatenated Matrices with MS Kinect: A Contribution to Interiors Architecture." In Computational Science and Its Applications – ICCSA 2020. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-58817-5_49.

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Karaca, Yeliz, and Dumitru Baleanu. "Multifractional Gaussian Process Based on Self-similarity Modelling for MS Subgroups’ Clustering with Fuzzy C-Means." In Computational Science and Its Applications – ICCSA 2020. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-58802-1_31.

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Jerz, Gerold, Derek Gutzeit, and Peter Winterhalter. "Characterization of Acylated Flavonoid Glycosides from Sea Buckthorn (Hippophaë rhamnoides) Juice Concentrate by Preparative HSCCC/ESI-MS-MS." In ACS Symposium Series. American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1035.ch016.

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Herderich, Markus. "HPLC-MS Analysis of Carotenoid-Derived Aroma Precursors." In ACS Symposium Series. American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2002-0802.ch003.

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Eargle, John M. "Mid-Side (MS) and XY Microphone Pairs." In Electroacoustical Reference Data. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2027-6_82.

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Hammerstone, John F., and Sheryl A. Lazarus. "HPLC-MS Analysis of Flavonoids in Foods and Beverages." In ACS Symposium Series. American Chemical Society, 2000. http://dx.doi.org/10.1021/bk-2000-0754.ch038.

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Sasama, Hiroko, Yoshitake Takada, Masao Ishimoto, Keisuke Kitamura, and Chigen Tsukamoto. "Estimation of the Mutation Site of a Soyasapogenol A-Deficient Soybean [Glycine max (L.) Merr.] by LC-MS/MS Profile Analysis." In ACS Symposium Series. American Chemical Society, 2010. http://dx.doi.org/10.1021/bk-2010-1059.ch006.

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Heck, Michael, Klaus Blaum, R. Burcu Cakirli, et al. "Dipolar and quadrupolar detection using an FT-ICR MS setup at the MPIK Heidelberg." In TCP 2010. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-2588-1_36.

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Conference papers on the topic "MS 2020"

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Mostovoy, Pavel, Ildar Safarov, Evgeniy Tumanov, Maria Zaytseva, Maksim Aksenov, and Vladimir Vorobyev. "Retrospective Analysis of Geological Exploration 2010 - 2020." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206044-ms.

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Abstract Oil and gas companies’ future production profile is shaped by their exploration strategy and resource base development. Gazprom Neft's production profile will include 40% of current exploration projects by 2030. Geological exploration, on the other hand, is a high-risk business because it involves a lot of uncertainty due to the geological complexity of the targets being explored, as well as a lot of risky capital. Taking these factors into account, the Company will need to expand its exploration function as well as its approaches to managing exploration projects in order to meet its lofty aims. To determine the key areas of growth and a strategy for the exploration function development in the coming years, it was decided to first analyze the geological exploration activity in the Company in 2010 – 2020 period. The knowledge of achievements, success stories, and development areas is the fulcrum for future victories. Therefore, retrospective analysis is an important tool for the development of any system of activity - individual, organization, or state.
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Subarkah, Darwinaji, Morgan L. Blades, Eilidh Cassidy, et al. "IN-SITU RB-SR DATING AND ELEMENTAL FINGERPRINTING OF SHALES AND DOLERITE BY LA-ICP-MS/MS." In GSA 2020 Connects Online. Geological Society of America, 2020. http://dx.doi.org/10.1130/abs/2020am-355642.

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Coupland, Sam Peter. "The Journey to Net Zero: Driving Down Emissions from Bp's North Sea Operations." In SPE Offshore Europe Conference & Exhibition. SPE, 2021. http://dx.doi.org/10.2118/205469-ms.

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Abstract bp's strategy sets out a decadeof delivery towards becoming a net zero company by 2050 (or sooner) with targets set for emissions from operations to fall by between 30-35% by 2030. In pursuit of this, a North Sea carbonplan has been developed to identify, track, and deliver sustainable emission reductions (SERs) activities. Proactive engagement has been essential in delivery of this plan, helping to empower colleagues to prioritize emissions reduction opportunities. To date, the plan has identified more than 80 SERs across bp's North Seaportfolio and cumulatively reduced carbonemissions by more than 400,000 tonnes from offshore operations. It is on track to reduce almost 70,000tonnes of carbon from operations in 2021 alone. Whilst it is recognised that this represents only part of bp's annual scope 1 emissions in the North Sea; this is a lasting operational improvement. The plan has also significantly reduced sources of unknown flare gas. It also contributed to a 45% reduction in flare activity in 2020 vs 2019as well as achieving zero routine flaringon two of bp's major west of Shetland installations from October 2020 The plan has more deeply embedded emissions tracking in operations on and offshore and helped further improve working practices on flaring and energy efficiency in general.
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Dokwal, Dhiraj. "ESI-MS and MALDI-MS imaging reveals differences in membrane lipids of M. truncatula dules under phosphorus stress." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1047353.

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Nimie, Hemlata M., and Minakshi N. Deodhar. "Method Development and Force Degradation Study for Daclatasvir Using LC-MS/MS." In 2020 Advances in Science and Engineering Technology International Conferences (ASET). IEEE, 2020. http://dx.doi.org/10.1109/aset48392.2020.9118229.

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Podlesnyi, Aleksei, Vladimir Kurkin, and Mark Cedrik. "Ionosond-MS ionosonde receiving antenna system." In 2020 7th All-Russian Microwave Conference (RMC). IEEE, 2020. http://dx.doi.org/10.1109/rmc50626.2020.9312232.

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Podlesnyi, Aleksei, Vladimir Kurkin, and Mark Cedrik. "Ionosond-MS ionosonde receiving antenna system." In 2020 7th All-Russian Microwave Conference (RMC). IEEE, 2020. http://dx.doi.org/10.1109/rmc50626.2020.9312232.

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Boberg, Emma, Cecilia Lässer, Carina Malmhäll, Kristina Johansson, Henric Olsson, and Madeleine Rådinger. "Quantitative LC-MS/MS identifies significantly altered protein profiles in bronchial lavage fluid in non-allergic and allergic asthma." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.4082.

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Belisario, Jose, Santanu Mondal, Iman Khakpour, Alexandar Franco Hernandez, Andriy Durygin, and Zhe Cheng. "Synthesis and Flash Sintering of (Hf1-xZrx)B2 Solid Solution Fine Powders." In Materials Science & Technology 2020 (MS&T20). US DOE, 2020. http://dx.doi.org/10.2172/1735475.

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ROBERTA PAES FUJIHARA, JULIANA, Cesar Yuji Fujihara, and PATRICIA HELENA MIRANDOLA GARCIA. "PERCEPÇÃOAMBIENTAL DOS MORADORES DA VILA “FAVELINHA” (CORUMBÁ, MS) SOBRE O PANTANAL." In CONINTER 2020. Even3, 2020. http://dx.doi.org/10.29327/coninter2020.299735.

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Reports on the topic "MS 2020"

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Building Profitable and Sustainable Community Owned Connectivity Networks. Academy of Science of South Africa (ASSAf), 2021. http://dx.doi.org/10.17159/assaf.2019/0065.

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The IID seminar titled “Building Profitable and Sustainable Community Owned Connectivity Networks”, was hosted on 31 August 2020 on Zoom Webinar. The 2019 White Paper on science, technology and innovation (STI) recognise the pivotal enabling role of information and communication technologies (ICTs) in realising an inclusive and prosperous information society and knowledge economy. One of the Department of Science and Innovation (DSI)’s key role is to catalyse the digital ecosystem and develop scalable models for community owned connectivity networks to replicate in other areas. Rural areas provide challenging environment to implement communication infrastructure for data and Internet based services, including high cost of network implementation and lack of customer base, low-income streams, highly scattered and low population density. The DSI has thus partnered with the University of Western Cape (UWC), the Mankosi Village community, with support from the Technology Innovation Agency (TIA) to scaleup the Zenzeleni Community Owned Connectivity Networks (COCN). The Zenzeleni COCN has been in existence since 2012 and provides timely, reliable and affordable Wi-Fi connectivity to the remote rural areas of Mankosi and Zithulele in Mthatha. The webinar, facilitated by Ms Ellen Fischat from Story Room aimed to look at how rural and township wireless connectivity models, including Zenzeleni COCN can be scaled-up to increase the number of people connected in the rural settings, more so in light of the COVID-19 crisis. It is evident from the proceedings the need for community networks to provide access to connectivity and also more importantly, what connectivity enables. Subsequent discussions would need to focus on the users and owners of these community networks to understand how their lives have improved through the deployment of the technology. This will shed light of the financial feasibility and benefit.
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