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Dissertations / Theses on the topic 'MS detection'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tevell, Åberg Annica. "Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98348.

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This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. The metabolism of clemastine, flutamide, and meloxicam were studied in vitro and/or in vivo in different species such as humans, dogs, and horses. Accurate mass measurements with the quadrupole-time of flight mass spectrometer and MSn data supplied by the ion trap instrument

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2

Egan, Martin Joseph. "Analysis of polyhydroxyalkaloids in plant extracts by chromatography and mass spectrometry : including sequential tandem MS." Thesis, University of Greenwich, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324932.

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3

Wong, Chun-kit Jack. "Application of immunochemical and LC/MS/MS techniques in the detection of sulfonamide residues in livestock /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36886294.

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4

Schmidt, Benita. "Detection and Characterisation of Nanoparticles using Inductively Coupled Plasma Mass Spectrometry." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20162.

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In dieser Doktorarbeit wurde eine analytische Methode zur Charakterisierung metallischer Nanopartikel (NPs) entwickelt und die Methode bei der Untersuchung natürlicher Proben angewendet. Mit einem analytisches System bestehend aus einem Mikrotropfengenerator (microdroplet generator, MDG) zusammen mit einem pneumatischen Zerstäuber und einem induktiv gekoppeltem Plasma-Massenspektrometer (ICP-MS) konnte eine quantitative und qualitative Charakterisierung von NPs durchgeführt werden. Der MDG wurde verwendet um die Kalibrierungsfunktion für die massenspektrometrische Quantifizierung der Metalle

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5

Bunch, Josephine. "Detection and imaging of pharmaceutical compounds in skin by MALDI-MS." Thesis, Sheffield Hallam University, 2005. http://shura.shu.ac.uk/19408/.

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Mass spectrometric techniques have been developed recently for the examination of biological tissue samples. Tandem mass spectrometry has been employed for the detection of pharmaceutical compounds and also mass spectrometric 'images' have been produced which show the spatial distribution of peptides, proteins and drugs in tissue. In this thesis, a programme of method development for the detection and imaging of topically applied pharmaceutical compounds in porcine epidermal tissue by MALDI-TOF-MS is presented. Direct analysis of fresh tissue sections was compared with the analysis of tissue i

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6

Gómez, Castellà Cristina 1985. "Improving detection capabilities of doping agents by identification of new phase I and phase II metabolites by LC-MS/MS." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/132539.

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Metabolic studies of doping agents have been traditionally performed by using gas chromatography coupled to mass spectrometry (GC-MS). In the last years, liquid chromatography coupled to mass spectrometry (LC-MS) has demonstrated to offer new possibilities to perform metabolic studies. The objective of this thesis was to study the metabolism (phase I and phase II) of different doping agents by LC-MS/MS in order to improve the detection capabilities of the studied substances. For mesocarb, a thermolabile compound, the parent drug 19 metabolites were detected in urine including mono-, di- and t

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7

Demir, Cevdet. "Detection of metabolites by GC-MS and analysis of mixtures by chemometric." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388014.

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8

Nixon, Christopher E. "2ND TIER ASSAY FOR THE DETECTION OF CONGENITAL ADRENAL HYPERPLASIA BY VIRGINIA’S NEWBORN SCREENING LABORATORY: STEROID PROFILE BY HPLC-MS/MS." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6075.

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Congenital Adrenal Hyperplasia (CAH) encompasses several disorders related to disruptions in the adrenal steroid production pathway. These disruptions may cause virilization of the external female sex organs, incorrect gender assignment, precocious puberty, and in the most severe form, may cause life-threatening salt wasting and adrenal crisis if not detected and treated early in the newborn period. 17α-Hydroxyprogesterone (17-OHP) is the primary target for immunofluorescence detection of CAH from dried blood spots in newborn screening (NBS). Unfortunately, current immunoassay techniques for t

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9

Kay, Richard G. "The application of proteomic technologies to the detection of the abuse of gene therapy and protein therapeutic agents." Thesis, Loughborough University, 2010. https://dspace.lboro.ac.uk/2134/6969.

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An acetonitrile based protein extraction method was developed that demonstrated high efficient and effective removal of high abundant proteins from both human and murine serum. The protein content of the extract was characterised using gel electrophoresis, the Bradford assay and liquid chromatography tandem mass spectrometry (LC-MS/MS) with database searching. Selected reaction monitoring (SRM) analysis was used to quantify the levels of high abundant serum proteins to further validate the extraction methodology. The ACN depletion method, in combination with artificial neural networks (ANNs) d

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10

Schumacher, Joshua. "Carbon Nanotube Enhanced MALDI MS: Increasing Sensitivity Through Sample Concentration." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3595.

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Matrix-assisted laser desorption/ionization (MALDI) is a technique used in mass spectrometry for the ionization of biomolecules. A matrix solution is mixed with the analyte molecules to be investigated, and then spotted onto a specialized MALDI plate. The solvents evaporate leaving only the re-crystallized matrix with analyte dispersed throughout the crystals. Sample ionization is accomplished with a laser in the MALDI instrument. The spot diameter of the target is usually several orders of magnitude larger than the diameter of the laser, making it necessary to perform multiple laser investiga

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11

Olsson, Linnea. "Detection of synergistic activity of antibiotics in Klebsiella pneumoniae using MALDI-TOF MS." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-45032.

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12

Planinc, Ana. "Detection of changes in n-glycosylation profiles of therapeutic glycoproteins using LC-MS." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/241427/4/Table.pdf.

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Biopharmaceuticals are becoming one of the most promising drugs on the market mainly due to their successful treatment of a vast array of serious diseases, such as cancers, immune disorders, and infections. Structurally, biopharmaceuticals are proteins and it is important to mention that more than 60 % of biopharmaceuticals are glycosylated. Glycosylation is one of the most common posttranslational modifications. It is also the most demanding and the most complex posttranslational modification. The research showed that glycosylation can significantly impact on the safety, efficiency, and quali

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13

Jora, Manasses. "Higher-energy Collisional Dissociation (HCD) as a Complementary Tool for Expanding the Detection and Discovery of Modified Ribonucleosides by LC-MS/MS." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613747846885246.

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14

Tuke, Philip William. "Molecular techniques for the detection and characterisation of a novel retrovirus associated with multiple sclerosis." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368078.

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15

Wynn, Michelle Arelia Ann. "Biology and Detection of Pregnanes During Late Gestation in the Mare." UKnowledge, 2017. http://uknowledge.uky.edu/gluck_etds/28.

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Progesterone in the mare declines to almost undetectable concentrations in late gestation. It’s metabolized into several pregnanes, some circulating at very high concentrations. Although the function of many pregnanes remains unclear, 5α-dihydroprogesterone and allopregnanolone are bioactive. Measurements of pregnanes in late gestation are typically by immunoassay, although results are confounded by cross-reactivity with related pregnanes. Conversely, liquid chromatography tandem mass spectrometry (LC-MS/MS) allows differentiation of individual pregnanes. The purposes of these studies were: 1)

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16

Tarifa, Anamary. "Fast Detection and Chemical Characterization of Gunshot Residues by CMV-GC-MS and LIBS." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2264.

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Gunshot residue (GSR) is the term used to describe the particles originating from different parts of the firearm and ammunition during the discharge. A fast and practical field tool to detect the presence of GSR can assist law enforcement in the accurate identification of subjects. A novel field sampling device is presented for the first time for the fast detection and quantitation of volatile organic compounds (VOCs). The capillary microextraction of volatiles (CMV) is a headspace sampling technique that provides fast results (< 2 min. sampling time) and is reported as a versatile and high-ef

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17

Deininger, Lisa. "Multi-informative and specific detection of blood in fingermarks via MALDI-MS based strategies." Thesis, Sheffield Hallam University, 2018. http://shura.shu.ac.uk/22431/.

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Currently employed enhancement and detection techniques for blood are not confirmatory due to targeting generic compound classes like proteins. As such, they are not sufficiently specific and are prone to false positives. The aim of this work was to confidently determine whether a crime scene sample is in fact blood and more specifically human blood. To achieve this, an in-solution bottom up proteomic approach was developed, targeting blood-specific proteins and employing MALDI-MS. The work was developed further to devise a protocol for proteomic in situ analysis of bloodied fingermarks with M

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18

Alberts, P. "Development of a novel LC-MS/MS method for the detection of adulteration of South African sauvignon blanc wines with 3-alkyl-2-methoxypyrazines." Thesis, Link to the Internet, 2008. http://hdl.handle.net/10019/805.

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19

Methling, Maximilian [Verfasser]. "Detection of psychoactive substances (antidepressants, antipsychotics, benzodiazepines, alcohol) in human hair and other matrices using liquid chromatography-mass spectrometry (LC-MS/MS) / Maximilian Methling." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1217251324/34.

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20

Saba, Elias. "Detection and Quantification of PCB insoil using GC/MS : - method development and education for users." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-126489.

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The aim of this paper is to document the development of a method for detectionand quantification of Polychlorinated biphenyls (PCB) in soil using GasChromatography (GC) connected to a Quadrupole Mass Spectrometer (MS) via aninternal standard (CB189). The method developed is performed in conjunction withthe information provided by the Swedish environmental agency (Svenskanaturvårdsverket, SNV) in regards to PCB limits for sensitive land usage. The steps ofthe method and maintenance of the GC/MS are used to create a user manual andan attempt at transformative learning is done in an effort to tea

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21

Barreras, Garcia Alvaro. "Food safety: developement of new methods for marine algal toxins detection." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8644.

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2011/2012<br>SUMMARY Biotoxins produced by harmful algae during their proliferation can be accumulated by filter feeding organisms, such as bivalve shellfish, within their flesh. Furthermore, these toxins gradually are transferred to the higher trophic levels in the food chain, posing a threat to human health, after consumption of contaminated seafood. Filter-feeding invertebrates are organisms in which the toxin accumulation is a well-known phenomenon, especially during harmful algal blooms. Mussels, cockles, oysters, and scallops feed on toxic dinoflagellates, transferring them from the

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22

Joshi, Ubisha. "Characterization of Ionic Liquid As a Charge Carrier for the Detection of Neutral Organometallic Complexes Using Electrospray Ionization Mass Spectrometry." Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc149615/.

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A novel application of ionic liquid as a charge carrier for the analysis and detection of neutral organometallic complexes using a mass spectrometer has been presented. The mass spectrometer detects only charged compounds which raise a difficulty in analyzing a neutral molecule that lacks a basic site to associate with charge. Therefore, an effective way of providing charge has always been an area of keen interest in the field of mass spectrometry. Ionic liquids have a very fascinating property of forming a cation-? interaction with other molecules to give a charged complex. In order to take a

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23

Strayer, Kraig Edward. "A LC-MS/MS-Based Method for the Multiplex Detection of 24 Fentanyl Analogs and Metabolites in Whole Blood at Sub ng mL^-1 Concentrations." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1527173022936317.

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NOBILE, MARIA. "DEVELOPMENT AND VALIDATION OF METHODS FOR THE DETECTION OF RESIDUES IN UNCONVENTIONAL AND INNOVATIVE MATRICES THROUGH LC-MS/MS ANALYSES FOR SAFETY OF FOOD OF ANIMAL ORIGIN." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/547683.

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Successful animal growth depends on a combination of many factors related to health, management and nutrition. The use of veterinary drugs in food-producing animals for therapeutic purposes is regulated (corticosteroids, antibiotics) or banned (anabolic steroids) in the European Union; however, their use as growth promoters cannot be excluded. Moreover, the eventual presence of residues in food constitutes a fraud and a health issue for the consumers. For these reasons the need to find new accumulation matrices and new sensitive, specific and robust methods that are able to reveal the presence

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25

Wei, Li. "Part I: Oxidative Modification of Ethanolamine Phospholipids by Isolevuglandins: Detection by LC-MS/MS in Vitro and in Vivo Part II: Total Synthesis of C22-11-isolevuglandin E4." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251210773.

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26

Nicolaou-Markide, Nicoletta. "The use of analytical techniques for the rapid detection of microbial spoilage and adulteration in milk." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-use-of-analytical-techniques-for-the-rapid-detection-of-microbial-spoilage-and-adulteration-in-milk(014652ea-b404-4bd5-bd8b-5b91bcb06cff).html.

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Milk is an important nutritious component of our diet consumed by most humans on a daily basis. Microbiological spoilage affects its safe use and consumption, its organoleptic properties and is a major part of its quality control process. European Union legislation and the Hazard Analysis and the Critical Control Point (HACCP) system in the dairy industry are therefore in place to maintain both the safety and the quality of milk production in the dairy industry. A main limitation of currently used methods of milk spoilage detection in the dairy industry is the time-consuming and sometimes labo

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27

Li, Haorong. "Development of Secondary Electrospray Ionization Tandem Mass Spectrometry and its Application in Bacterial Headspace Volatile Organic Compounds Detection." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1533210755679687.

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28

Kerr, Samantha Louise. "Enhancing nucleic acid detection using inductively coupled plasma mass spectrometry, by means of metal and nano-particle labelling." Thesis, Loughborough University, 2008. https://dspace.lboro.ac.uk/2134/4641.

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The application of ICP-MS to the fields of proteomics and genomics has arisen in part due to its ability to detect and quantify trace levels of S and P, which are major constituents in proteins and nucleic acids respectively. The development of collision/reaction cell technology and high resolution instruments has enabled these biologically important elements to be measured and quantified at the pg - ng ml-1 level. Despite these advances, the detection limits of P and S are still inferior compared to other elements. Oligonucleotides containing biotin functionality were labelled with Au nano-pa

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29

Carlin, Michelle. "Development and evaluation of an LC-ESI-MS method for the simultaneous detection of five major opium alkaloids." Thesis, Northumbria University, 2015. http://nrl.northumbria.ac.uk/27317/.

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The aim of this work was to establish an analytical method for the simultaneous detection of five major opium alkaloids in poppy seeds by liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS). Once opium alkaloids were detected in poppy seeds, toxicological studies were carried out to establish if these compounds were detected in oral fluid (OF) of participants who ingested muffins containing poppy seeds. It is known that the ingestion of poppy seeds has caused positive opiate drug test results and much work has been reported in the scientific literature in the last 20 ye

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Manzoor, K. "Detection and analysis of spin trapped radical adducts using thermal desorption gas chromatography mass spectrometry (TD-GC-MS)." Thesis, University of Salford, 2018. http://usir.salford.ac.uk/48345/.

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Certain oxygen free radicals are produced constantly in cells by metabolism and exogenous agents. Some, such as the hydroxyl radical, may react with various biomolecules like DNA, lipids or proteins, and thus be involved in the pathogenesis of various diseases. It is often difficult to detect oxygen free radicals due to their relatively short half-life. This problem may be overcome, however, using the spin trapping technique. In this technique, the spin-trap compound is used to trap free radicals, making them stable enough to be analysed using techniques like Electron Paramagnetic Resonance (E

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Shi, Jianzheng. "Nitrosation studies of tolazoline, an antihypertensive drug and LC/MS detection of DNA adducts derived from N-nitrosotolazoline /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074442.

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Esquivel, López Argitxu 1989. "Control of anabolic steroids misuse in sport : potential of direct detection of phase II metabolites." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665719.

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Anabolic androgenic steroids (AAS) are widely used by athletes to enhance sports performance. In this thesis, different studies were performed to evaluate the potential of the direct detection of phase II metabolites by LC-MS/MS to improve the detection of AAS misuse in sport. First, the direct detection of glucuronide metabolites was investigated using metandienone, allowing the detection of thirteen glucuronides, one of them resistant to enzymatic hydrolysis. The proposed analytical strategy provides a comprehensive approach and it is recommended to be used for metabolic studies of other

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Henderson, Brandon. "Use of ion molecule reactions in inductively coupled plasma mass spectrometry(ICP-MS) to improve selenium analysis and detection." Connect to resource, 2006. http://hdl.handle.net/1811/6574.

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Thesis (Honors)--Ohio State University, 2006.<br>Title from first page of PDF file. Document formatted into pages: contains 38 p.; also includes graphics. Includes bibliographical references (p. 35-38). Available online via Ohio State University's Knowledge Bank.

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Simon, Alison G. "The Detection of an Invasive Pathogen through Chemical and Biological Means for the Protection of Commercial Crops." FIU Digital Commons, 2017. https://digitalcommons.fiu.edu/etd/3558.

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Standoff detection of targets using volatiles is essential when considering substances that are hazardous or dangerous, or for which the presence or location is unknown. For many invasive biological threats, their presence is often not realized until they have begun visibly affecting and spreading through crops or forests. The fungus Raffaelea lauricola is a biothreat vectored by the invasive beetle Xyleborus glabratus, or redbay ambrosia beetle (RAB), whose presence in avocado groves is currently detectable by visual inspection. Once visually identified, the affected trees must be removed and

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35

Höfig, Carolin. "Establishment, validation and application of immunological and LC-MS/MS-based detection methods to study the role of human aromatic L-amino acid decarboxylase as an enzyme potentially involved in thyronamine biosynthesis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16645.

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Thyronamine (TAM) sind eine neue Molekülklasse, die endokrinologische und metabolische Prozesse miteinander vereinen. Der biologisch aktive Metabolit 3-Iod-L-Thyronamin (3-T1AM) wird durch eine kombinierte Deiodierung und Decarboxylierung von Schilddrüsenhormonen (TH) gebildet. Existierende Methoden zum Nachweis und zur Quantifizierung von 3-T1AM im menschlichen Serum sind immer noch umstritten. Auch die an der Biosynthese vermutlich beteiligte TH-Decarboxylase konnte noch nicht identifiziert werden. Für die Identifizierung und Quantifizierung von TH und TAM Profilen wurde die Flüssigchromatog

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Li, Meihui. "A comprehensive study of natural organic dyes in historical mediterranean textil by liquid chromatography with photodiode array and mass spectrometric detection." Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/27739.

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Thesis involves an optimized chromatographic and spectroscopic study of textiles, dyed with natural organic dyestuffs, aiming at the identification of chromophore constituents and their possible degradation products. Liquid chromatography - mass spectrometry coupled with photodiode array detection has been applied for the samples’ analyses after the selective extraction of chromophores from the substrate. The under investigation natural organic dyes are those with a particular cultural value since they have been widely used for textiles staining in the Mediterranean region since Antiquit

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Mishra, S. K. "Detection and analysis of spin trapped radical adducts by using alpha-phenyl-tert-butyl nitrone (PBN) derivatives and GC/MS." Thesis, University of Salford, 2016. http://usir.salford.ac.uk/39302/.

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Davis, William Henry. "Development of a high-throughput genotyping assay for detection of functional polymorphisms involved in homocysteine metabolism and the methylation process implicated in multiple sclerosis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95457.

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Thesis (MMedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown due to the multifactorial nature of disease susceptibility determined by both environmental and genetic factors. Progress has been made in identifying the genetic component of MS , as well as the possible interactions with the environment. In this study single nucleotide polymorphisms (SNPs) in the FTO (rs9939609, Intron 1 T>A), MTR (rs1805087, 2756 A>G), MTRR (rs1801394, 66 A>G), MTHFR (rs1801133, 677 C>T and rs1801131, 1298 A>C) and COMT (rs46

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Trefjord, Terese. "Investigations on the Applicability of Membrane Introduction as a Sampling Technique for Oil in Air and Water with Flame Ionization Detector (FID) and Mass Spectrometry (MS) Detection." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for kjemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16363.

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During a membrane introduction (MI) analysis the analytes are separated from the bulk matrix (e.g. air or water) by a semi-permeable membrane and transported to the detector by a carrier gas (usually helium). The most commonly used detector for MI-analyses is the mass spectrometer, resulting in membrane introduction mass spectrometry (MIMS). The main advantages of MIMS are short response times, high sensitivity, simplicity and elimination of sample preparation and pre-separation. Membrane introduction analyses are suitable for detection of volatile organic compounds (VOCs) and semi volatile or

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MARIN, RAFAEL C. "Desenvolvimento de metodologias utilizadas nas áreas de salvaguardas e forense nuclear baseadas na técnica LA-HR-ICP-MS." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10589.

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Made available in DSpace on 2014-10-09T12:42:16Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T14:05:15Z (GMT). No. of bitstreams: 0<br>Dissertação (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP

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Mulloor, Jerome. "Evaluation of Cryofocusing Capillary Microextraction of Volatiles for Improved Detection of Organic Gunshot Residue on the Hands of Shooters." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3197.

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The capillary microextraction of volatiles (CMV) device was equipped with a novel Peltier cooler to investigate cryofocused extraction of organic gunshot residue (OGSR) for the first time. Prior research demonstrated the CMV’s capabilities for detecting nitroglycerin, 2,4-dinitrotoluene, diphenylamine, and ethyl centralite on shooters’ hands via gas chromatography-mass spectrometry. Further method development increased the recoveries of these four target compounds with an optimal 20-minute equilibrium time at 80˚C followed by extracting 3 L at a 1 L/min flow rate. The Cryo-CMV was evaluated fo

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Chintalapudi, Kavyasree. "Development of Reactive Nano-Electrospray Mass Spectrometry (nESI-MS) Platform for Studying Electro-Catalytic Reactions using Non-Inert Electrodes." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1619043596792908.

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Brannegan, Daniel Robert. "Analysis of Ethoxyquin and its Oxidation Products using Supercritical Fluid Extraction and High Performance Liquid Chromatography with Chemiluminescent Nitrogen Detection." Thesis, Virginia Tech, 2000. http://hdl.handle.net/10919/31575.

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Ethoxyquin is an antioxidant commonly used to preserve vitamins and lipids in various food products and animal feeds. The extraction and determination of ethoxyquin is becoming increasingly important as products, which are labeled as "natural" are becoming more common. The present method of determination only ensures that ethoxyquin values are below 10-20 parts per million. Therefore, advances are needed in methods of extraction and analysis in order to lower the detection limits in various products. The first part of this research investigates the use of supercritical fluids in the extrac

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Fields, Robert Eugene 1958. "Application of a quadrupole ion trap mass spectrometer to ICP-MS and the direct detection of x-rays using a charge-injection device." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282314.

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This work describes the construction of an inductively-coupled plasma tandem quadrupole mass spectrometer where a quadrupole ion storage trap acts as a second sector and collision cell to achieve neutralization or collisional dissociation of interfering species before mass analysis. Because most elements exist as singly-charged ions in an inductively-coupled plasma (ICP) plume, the ICP can be used as an ionization source for mass analysis (ICP/MS). By reducing the sample to elemental ions before mass analysis, ICP/MS spectra tend to be simple compared with those obtained by ICP-optical emissio

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Maurer, Katja. "Oral brush biopsy analysis by MALDI-ToF Mass Spectrometry for early cancer diagnosis." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-116691.

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Objectives: Intact cell peptidome profiling (ICPP) with MALDI-ToF Mass-Spectrometry holds promise as a non invasive method to detect head and neck squamous cell carcinoma (HNSCC) objectively, which may improve the early diagnosis of oral cancer tremendously. The present study was designed to discriminate between tumour samples and non-cancer controls (healthy mucosa and oral lesions) by analysing complete spectral patterns of intact cells using MALDI-ToF MS. Material and Methods: In the first step, a data base consisting of 26 patients suffering from HNSCC was established by taking brush biop

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Alothaim, Ibrahim. "Applications of LC-MS metabolomic profiling in inflammatory bowel disease and the development of derivatisation methods to enhance selective detection of certain compound classes." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=29531.

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Inflammatory bowel disease (IBD) is a chronic inflammation of all parts of the gastrointestinal tract and is represented by two major variations, ulcerative colitis (UC) and Crohn's disease (CD). It is diagnosed based on the pattern of inflammation. In order to understand the pathology of the disease better urine and saliva samples were collected from patients with IBD, patients in remission and a control group. The metabolomes of the urine and saliva samples were profiled by carrying out chromatography on a ZICpHILIC column in combination with high resolution mass spectrometry. It was possibl

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Huang, Shih-Yen, and 黃詩雁. "Quantitative detection of aloin in aloe drinks using LC-MS/MS method." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/87102055253558448724.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>103<br>Aloe has been extensively used for health drinks, external ointments, toiletries and cosmetics. Its physiologically active substances included aloe emodin, saponin and aloin, of which aloin possessed antioxidant capacity and diarrhea effect. The domestic beverage shops and supermarkets offer a variety of aloe drinks and related products, of which the product aloe juice with honey is the most popular. Little information of aloe drinks has been available. The purpose of this study was to investigate the contents of aloin in aloe drinks and related products purch

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Johnson, Renee Michelle. "Determining the analytical figures of merit from LC-MS/MS data." Thesis, 2017. https://hdl.handle.net/2144/26678.

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Synthetic drugs such as piperazines are among the most commonly abused drugs and are typically consumed by younger populations. Because of their popularity, developing optimized analytical strategies designed to improve detection and interpretation of synthetic piperazines is of interest to the forensic community. To improve the likelihood that a substance of interest is detected, careful evaluation into the mass spectrometry signal is required. However, with all analytical pursuits, there is a limit at which the substance cannot be detected with certainty; thus a threshold is commonly referre

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Lin, Yi-Zhun, and 林怡諄. "Detection of Pyrrolizidine Alkaloids in Emilia sonchifolia (L.) DC. by LC/MS/MS." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/44508469133042738700.

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碩士<br>亞洲大學<br>保健營養生技學系<br>102<br>Emilia sonchifolia (L.) DC. (Lilac tasselflower, yi dain hong, Asteraceae). It’s effectiveness has anti-inflammatory, detoxifying, antipyretic , anti-fever and other effects. In this study, we have investigated the hepatotoxic and tumorigenic pyrrolizidine alkaloids (PAs) contained in Emilia sonchifolia (L.) DC. collected from several towns in Taiwan. Two structural types of PAs were identified from the ground whole plant by liquid chromatography (HPLC) method：otonecine bases，e.g. otosenine, petasitenine, desacetyldoronine, neosenkirkine, senkirkine, crotafolin

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Liu, Hsin-Tung, and 劉芯彤. "Improved simultaneous detection of polar and nonpolar drugs by bimaterial hybridized column on nanoLC-MS/MS system." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/25543927320277932872.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>105<br>Liquid chromatography coupling to mass spectrometry is widely used in several areas. In the forensic science or biological area, it is sometimes quite challenging for the detection of compounds in limited amount samples. The miniaturized Nano-LC present as a great choice for compensating this issue. Sixty-six drugs and phase I, II metabolites of acetylthebaine from heroin impurities were selected as our target analytes. A wide range of polarities are included which is quite difficult in detection within one sample shot due to the analytical column limited selec

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