Relevant bibliographies by topics / Ms polymorphism

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Ms polymorphism'

Author: Grafiati
Published: 9 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Ms polymorphism"

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Cakina, Suat, Ozgul Ocak, Adile Ozkan, Selma Yucel, and Handan Isin Ozisik Karaman. "Vitamin D receptor gene polymorphisms in multiple sclerosis disease: A case-control study." Revista Romana de Medicina de Laborator 26, no. 4 (2018): 489–95. http://dx.doi.org/10.2478/rrlm-2018-0028.

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Abstract Multiple sclerosis (MS) is a common neurologic disorder that is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Its etiology remains unknown. Several recent studies have found that decreased susceptibility to vitamin D deficiency is also associated with a decreased risk of MS. The role of vitamin D receptor (VDR) gene and its polymorphisms are highlighted as susceptible components. In this study, we aimed to identify the relationship between ApaI (rs7975232), BsmI (rs 1544410), and TaqI (rs731236) gene polymorphisms with MS. Ap
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Bulan, B., AY Hoscan, SN Keskin, et al. "Vitamin D receptor polymorphisms among the Turkish population are associated with multiple sclerosis." Balkan Journal of Medical Genetics 25, no. 1 (2022): 41–50. http://dx.doi.org/10.2478/bjmg-2022-0003.

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Abstract Multiple sclerosis (MS) is an inflammatory disease characterized by demyelination and axonal degeneration affecting the central nervous system. Among the genetic factors suggested to be associated with this disease are polymorphisms to the vitamin D receptor (VDR) gene. We tested the hypothesis that polymorphisms in the vitamin D receptor (VDR) gene are associated with MS. The aim of the study was to investigate the relationship of MS with the VDR gene Fok-I, Bsm-I and Taq-I polymorphisms among the Turkish population. This study contains 271 MS patients and 203 healthy controls. Genom
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Steinman, L., J. R. Oksenberg, and C. C. A. Bernard. "Polymorphism in MS." Neurology 42, no. 2 (1992): 466. http://dx.doi.org/10.1212/wnl.42.2.466-b.

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Hillert, J., and O. Olerup. "Polymorphism in MS." Neurology 42, no. 2 (1992): 467. http://dx.doi.org/10.1212/wnl.42.2.467.

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Titova, M. A., V. M. Alifirova, N. F. Musina та T. N. Nikolaeva. "The Role of <i>TNF</i>-α, <i>TNFRSF1A</i>, and <i>CD40</i> Genes Polymorfisms in Multiple Sclerosis in Tomsk Region". Нейрохимия 40, № 3 (2023): 292–98. http://dx.doi.org/10.31857/s1027813323020152.

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We studied the role of polymorphisms rs1800629 of the TNF-α gene; rs4149584 of the TNFRSF1A gene; rs6074022, rs1883832, rs1535045, rs11086996 of the CD40 gene in the onset, clinical course and response to treatment in multiple sclerosis (MS) in a group of 152 patients, living in Tomsk region. 707 volunteers without autoimmune diseases and pathology of the nervous system were included in control group. The allele C of the rs6074022 polymorphism of CD40 gene was associated with the risk of MS and contributed to the high rate of disease progression. The T allele of the rs6074022 polymorphism of C
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Gade-Andavolu, Radhika, David E. Comings, James MacMurray, et al. "RANTES: a genetic risk marker for multiple sclerosis." Multiple Sclerosis Journal 10, no. 5 (2004): 536–39. http://dx.doi.org/10.1191/1352458504ms1080oa.

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Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a beta-chemokine and has been detected in brain lesions of multiple sclerosis (MS) patients. Considering its potential role in MS, we screened two functional polymorphisms in the proximal promoter region of the RANTES in MS patients versus controls. Methods: We examined 140 postmortem brain samples from subjects with a primary diagnosis of MS, and peripheral blood samples from 216 control subjects. The RANTES-28C/G and -403G/A promoter polymorphisms were examined. All subjects were non-Hispanic Caucasians. Results: MS
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Dolcetti, Ettore, Antonio Bruno, Federica Azzolini, et al. "The BDNF Val66Met Polymorphism (rs6265) Modulates Inflammation and Neurodegeneration in the Early Phases of Multiple Sclerosis." Genes 13, no. 2 (2022): 332. http://dx.doi.org/10.3390/genes13020332.

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The clinical course of multiple sclerosis (MS) is critically influenced by the interplay between inflammatory and neurodegenerative processes. The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265), one of the most studied single-nucleotide polymorphisms (SNPs), influences brain functioning and neurodegenerative processes in healthy individuals and in several neuropsychiatric diseases. However, the role of this polymorphism in MS is still controversial. In 218 relapsing–remitting (RR)-MS patients, we explored, at the time of diagnosis, the associations between the Val66Met
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Araújo, Eduarda Pontes dos Santos, Severina Carla Vieira da Cunha Lima, Ony Araújo Galdino, Ricardo Fernando Arrais, Karla Simone Costa de Souza, and Adriana Augusto de Rezende. "Association of CYP2R1 and VDR Polymorphisms with Metabolic Syndrome Components in Non-Diabetic Brazilian Adolescents." Nutrients 14, no. 21 (2022): 4612. http://dx.doi.org/10.3390/nu14214612.

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Associations between vitamin D deficiency and metabolic syndrome (MS) have been reported; however, the underlying biological mechanisms remain controversial. The aim of this study was to investigate the associations of CYP2R1 and VDR variants with MS and MS components in non-diabetic Brazilian adolescents. This cross-sectional study included 174 adolescents who were classified as overweight/obese. Three CYP2R1 variants and four VDR variants were identified by allelic discrimination. The CYP2R1 polymorphisms, rs12794714 (GG genotype) (odds ratio [OR] = 3.54, 95% confidence interval [CI] = 1.24–
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Ďurmanová, Vladimíra, I. Shawkatová, J. Javor, et al. "VLA4 Gene Polymorphism and Susceptibility to Multiple Sclerosis in Slovaks." Folia Biologica 61, no. 1 (2015): 8–13. http://dx.doi.org/10.14712/fb2015061010008.

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Multiple sclerosis (MS) is an inflammatory autoimmune disease occurring in genetically sensitive individuals. As migration of immune cells into the CNS is facilitated by the Very Late Antigen 4 (VLA-4) integrin molecule, the VLA4 gene may be considered as a plausible candidate genetic risk factor for susceptibility to MS. Therefore, the objective of our study was to investigate the association between two genetic polymorphisms located in the VLA4 gene and the risk of multiple sclerosis. One hundred seventeen MS patients and 165 control subjects from Slovakia were genotyped for VLA4 gene SNP po
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Martinez-Hernandez, A., E. E. Perez-Guerrero, M. A. Macias-Islas, et al. "Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study." Journal of Immunology Research 2021 (December 23, 2021): 1–11. http://dx.doi.org/10.1155/2021/7523997.

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Background. Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease. Low vitamin D levels have been reported to be a risk factor for MS, and genetic variances could be implicated. The aim of this study was to evaluate the association of MS with rs10766197 polymorphism of CYP2R1 gene and rs10877012 polymorphism of CYP27B1 gene. The second aim was to analyse whether these polymorphisms are associated with the severity of the progression of MS. Material and Methods. In a case-control study, we included 116 MS patients and 226 controls, all of whom were Mexican Mestizo. MS was diagnos
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Dissertations / Theses on the topic "Ms polymorphism"

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Emmanuel, Alexandra. "Mise en place d’une approche protéomique en vue d’une application au diagnostic d’infections parasitaires congénitales." Electronic Thesis or Diss., Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB137.

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Au cours des deux dernières décennies, la spectrométrie de masse (MS) est devenue un outil incontournable dans la caractérisation des protéines comme les IgG. Ces anticorps assurent la protection de l'organisme contre les antigènes, qu'ils reconnaissent grâce aux domaines variables de leurs chaînes lourdes et légères. Des séquences polymorphes existent également au niveau des domaines constants CH2 et CH3 du fragment Fc, impliquant quelques acides aminés, qui définissent ainsi 34 allèles protéiques IGHG des 4 sous-classes d'IgG. Des relations sont établies entre certains de ces polymorphismes
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Glas, Michael. "Mutationsanalyse im p53-Gen bei Patienten mit Multipler Sklerose." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969662440.

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LOTTO, VALENTINA. "Nutrient-gene interactions within one-carbon metabolism and effects on epigenetic regulation through dna methylation in peripheral blood mononuclear cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/18016.

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Epigenetics is a field of molecular biology that copes with the study of gene function regulation without variations in DNA structure or nucleotide sequences. Among the main epigenetic phenomema in eukaryotic cells there are DNA methylation and post-traslational mechanisms among which the major are histone methylation and acetylation. Epigenetic changes are potentially reversible phenomena that are controlled also by nutritional factors as the methyl-donors involved in the folate cycle. Plasma levels of B vitamins, among which “in primis” plasma folate concentrations, are implicated in epig
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Eriksson, Jenny. "Studies of Eosinophil Cationic Protein (ECP) in vivo and in vitro : Impact of Genetic and Posttranslational Modifications." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8261.

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Mann, C. L. A. "The relationship of genetic polymorphisms to disease severity of multiple sclerosis." Thesis, Keele University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341244.

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The glutathione S-transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress. Certain GST loci are polymorphic, demonstrating alleles that are null (GSTMI/GSTT1), encode low activity variants (GSTPI), or are associated with variable inducibility (GSTM3). Interleukin-1 (IL- 1) alpha and beta are cytokines involved in recruitment of inflammatory cells, the process of inflammation, and blood-brain barrier breakdown and nerve regeneration. Polymorphisms of both GST and of a complementary interleukin-1 receptor antagonist have been associ
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Davis, William Henry. "Development of a high-throughput genotyping assay for detection of functional polymorphisms involved in homocysteine metabolism and the methylation process implicated in multiple sclerosis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95457.

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Thesis (MMedSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The aetiology of multiple sclerosis (MS) remains largely unknown due to the multifactorial nature of disease susceptibility determined by both environmental and genetic factors. Progress has been made in identifying the genetic component of MS , as well as the possible interactions with the environment. In this study single nucleotide polymorphisms (SNPs) in the FTO (rs9939609, Intron 1 T>A), MTR (rs1805087, 2756 A>G), MTRR (rs1801394, 66 A>G), MTHFR (rs1801133, 677 C>T and rs1801131, 1298 A>C) and COMT (rs46
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Vogl, Silvia [Verfasser], and Gilbert [Akademischer Betreuer] Schönfelder. "Investigation of individual differences in the metabolic elimination of drugs by the polymorphic enzymes CYP2C9, 2C19 and 2D6 based on metabolite profiling by LC-MS/MS / Silvia Vogl, geb. Baumann. Betreuer: Gilbert Schönfelder." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1019944765/34.

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Mossi, Altemir José. "Variabilidade genética e de compostos voláteis e semi-voláteis em Maytenus ilicifolia Mart. ex Reiss." Universidade Federal de São Carlos, 2003. https://repositorio.ufscar.br/handle/ufscar/1742.

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Made available in DSpace on 2016-06-02T19:29:41Z (GMT). No. of bitstreams: 1 TeseAJM.pdf: 1132829 bytes, checksum: d7a4ea748d124c0e0dddf18933cbad53 (MD5) Previous issue date: 2003-04-29<br>Universidade Estadual de Maringá<br>Genetic and chemical variability of Maytenus ilicifolia Maytenus ilicifolia is a native plant of Southern Brazil commonly used as a popular medicine for indigestion, gastritis and ulcers. The large use of this plant has increased the degradation of the species, and thus it is presently included in FAO´s list for priority species for studying and conservation in South Ame
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Al, Saabi Alaa. "Relevance of Ethylglucuronide as a marker of alcohol consumption : development of dosage methods and study of factors potentially affecting its production." Phd thesis, Université du Droit et de la Santé - Lille II, 2013. http://tel.archives-ouvertes.fr/tel-00992193.

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La consommation excessive d'alcool présente des risques élevés pour l'individu et pour la société ; elle est fréquemment associée à une augmentation du risque d'accidents, d'actes de violence, et peut également conduire à court et/ou à long terme à de graves maladies et à des problèmes sociaux. Dès lors, l'utilisation de marqueurs fiables permettant de détecter une consommation excessive d'alcool, ponctuelle ou chronique, s'avère nécessaire pour prévenir des conséquences néfastes de l'abus d'alcool. L'éthylglucuronide (EtG) est un marqueur d'alcoolisation utilisé en toxicologie clinique (alcoo
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Cansian, Rogério Luis. "Variabilidade genética e de compostos voláteis e semi-voláteis em populações nativas de llex paraguariensis (St. Hil.) do Brasil, visando a conservação da espécie." Universidade Federal de São Carlos, 2003. https://repositorio.ufscar.br/handle/ufscar/1862.

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Made available in DSpace on 2016-06-02T19:30:14Z (GMT). No. of bitstreams: 1 TeseRLC.pdf: 1717916 bytes, checksum: a24259cd3e84bb299a7f0093b50f8ad8 (MD5) Previous issue date: 2003-04-29<br>Universidade Estadual de Maringá<br>Ilex paraguariensis, known as mate tea, is processed in many ways and commercialized as tea, soluble powder, essences, and processed leaves for preparation of mate tea without sugar ( chimarrão and tererê ). Aiming the conservation of this species, this work studied the intra- and interpopulational genetic variabilities of I. paraguariensis and its volatiles and semi-v
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Book chapters on the topic "Ms polymorphism"

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Alonso, Sergio, Koichi Suzuki, Fumiichiro Yamamoto, and Manuel Perucho. "Methylation-Sensitive Amplification Length Polymorphism (MS-AFLP) Microarrays for Epigenetic Analysis of Human Genomes." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7768-0_8.

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van den Boom, Dirk, and Mathias Ehrich. "Discovery and Identification of Sequence Polymorphisms and Mutations with MALDI-TOF MS." In Methods in Molecular Biology. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-030-0_16.

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Singh, Kamaleshwar P. "Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR)." In Molecular Toxicology Protocols. Humana Press, 2014. http://dx.doi.org/10.1007/978-1-62703-739-6_6.

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Singh, Kamaleshwar P. "Analysis of Toxicants-Induced Alterations in DNA Methylation by Methylation-Sensitive-Random Amplified Polymorphic DNA-Polymerase Chain Reaction (MS-RAPD-PCR)." In Molecular Toxicology Protocols. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0223-2_11.

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Kajiwara, Hideyuki. "Gene Analysis Using Mass Spectrometric Cleaved Amplified Polymorphic Sequence (MS-CAPS) with Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF)." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1966-6_16.

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Armando León-Rodríguez, Diego, Julian Becerra, Juan Carlos Caicedo Mera, Luis Fernando Cardenas, Jorge Martínez Cotrina, and Diego Mauricio Aponte Canencio. "OXTR Gene Polymorphisms and Event-Related Potentials in Humans: A Systematic Review." In Oxytocin and Social Function. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.112631.

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Oxytocin receptor (OXTR) gene polymorphisms have been consistently associated with humans’ differences in sensitivity to social cues, social cognition, stress response, and brain activity. However, how social and affective neural processing differs across carriers of distinct OXTR gene polymorphisms remains unclear. This systematic PRISMA review is the first to examine the experimental literature on the relationship between OXTR polymorphisms and ERP components. Eight studies published between 2014 and 2019 were included. The rs53576 was the only OXTR gene polymorphism analyzed in all studies.
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Ghosal, Anima, Ragulan Ramanathan, Narendra S. Kishnani, Swapan K. Chowdhury, and Kevin B. Alton. "Chapter 12 Cytochrome p450 (cyp) and udp-glucuronosyltransferase (ugt) enzymes: role in drug metabolism, polymorphism, and identification of their involvement in drug metabolism." In Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS. Elsevier, 2005. http://dx.doi.org/10.1016/s1464-3456(05)80014-6.

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"Eels at the Edge: Science, Status, and Conservation Concerns." In Eels at the Edge: Science, Status, and Conservation Concerns, edited by Mei-Chen Tseng, Wann-Nian Tzeng, and Sin-Che Lee. American Fisheries Society, 2009. http://dx.doi.org/10.47886/9781888569964.ch4.

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&lt;em&gt;Abstract.—&lt;/em&gt;Polymorphic microsatellite loci as genetic markers were used to reject the null hypothesis of panmixia for the Japanese eel, &lt;em&gt;Anguilla japonica&lt;/em&gt;. Observed heterozygosity showed slight heterozygote deficiencies over all loci. One of the eight loci (MS-4) in one sample showed departure from Hardy-Weinberg equilibrium. Unbiased Nei’s genetic distances ranged from approximately 0.058 to 0.134. A slight genetic differentiation was determined by &lt;EM&gt;F&lt;/EM&gt;&lt;sub&gt;ST&lt;/sub&gt; and &lt;EM&gt;R&lt;/EM&gt;&lt;sub&gt;ST&lt;/sub&gt; statis
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Conference papers on the topic "Ms polymorphism"

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Everett, Tom, Jeremy Holtsclaw, Elliot McDonald, Vignesh Sathyaseelan, Zhichen Nian, and Nate Schultheiss. "Thermodynamic Stability Determination of MEA-Dithiazine Polymorphs: An Experimental and Computational Exercise." In SPE International Conference on Oilfield Chemistry. SPE, 2025. https://doi.org/10.2118/224230-ms.

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Abstract Substituted 1,3,5-triazines for hydrogen sulfide (H2S) scavenging have established themselves as reliable and economical solutions in the oil and gas industry. Aqueous MEA-triazine is the most used, non-regenerative scavenger in the industry, and its resulting reaction product, MEA-dithiazine, is a ubiquitous and well-studied molecule. However, despite its storied history as a H2S scavenger, only recently were the two reported crystalline polymorphic forms I and II of MEA-dithiazine identified and structurally compared. Polymorphism is defined as different crystal structures/forms of
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Shevcova, L., and N. Kozulina. "DATABASES FOR THE ASSESSMENT OF GENETIC DIVERSITY FOR SPRING BARLEY GORDEINS IN BREEDING AND SEED PRODUCTION IN THE KRASNOYARSK RESEARCH INSTITUTE." In The state and problems of agricultural science in Yenisei Siberia. Krasnoyarsk Scientific Research Institute of Agriculture is a separate division of the Federal Research Center KSC SB RAS, 2024. http://dx.doi.org/10.52686/9785605087908_117.

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The use of relational databases MS Access, cloud-based AirTable in the breeding process showed the possibility of assessing the genetic diversity of spring barley varieties by hordeincoding loci. It is shown that using filters and queries in the database is convenient to group varieties according to hordein formulas, analyze the level of intervarietal polymorphism and internal heterogeneity in different groups of Eastern Siberian spring barley variety samples, and distinguish varieties by the frequency of occurrence of specific hordein formulas. The possibilities of integrating different datab
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Haiying, Cheng, and Wang Weidong. "16S rRNA: Genes Comparative Analysis of Microbial Communities in Oil Reservoir With Nutrients Injection by Terminal Restriction Fragment Length Polymorphism Method." In International Symposium on Oilfield Chemistry. Society of Petroleum Engineers, 2007. http://dx.doi.org/10.2118/106398-ms.

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Sood, S., and P. Gouma. "Polymorphic Reactions and In-Situ Single Crystal Metal Oxide Nanowire Formation in TEM." In MS&T18. MS&T18, 2018. http://dx.doi.org/10.7449/2018mst/2018/mst_2018_770_776.

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Sood, S., and P. Gouma. "Polymorphic Reactions and In-Situ Single Crystal Metal Oxide Nanowire Formation in TEM." In MS&T18. MS&T18, 2018. http://dx.doi.org/10.7449/2018/mst_2018_770_776.

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Takacs, Gabor, and Zoltan Turzo. "Nodal System Analysis Using Object-Oriented Programming Techniques." In Petroleum Computer Conference. SPE, 1993. http://dx.doi.org/10.2118/26250-ms.

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Abstract In order to efficiently design a flowing or artificial lifted well and to choose the most economical producing equipment, one has to analyze its components in conjunction with the entire system. These kinds of analyses are customarily called Nodal System Analyses. The development of computer programs for Nodal System Analysis is a complicated and time-consuming task mainly due to the complexity of the system. A recently emerging programming technique, Object-Oriented Programming or OOP can provide programmers an excellent means for solving such difficult problems. The aim of this pape
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Machal, A. C., R. A. Flurer, T. W. Brueggemeyer, L. E. Ellis, R. D. Satzger, and K. R. Stewart. "RIBAVIRIN: The analysis of a polymorphic substance by LC-MS and FTIR spectroscopy." In The eleventh international conference on fourier transform spectroscopy. AIP, 1998. http://dx.doi.org/10.1063/1.55776.

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Zemlyanukhina, O. A., та E. N. Vasilchenko. "Comparative investigаtion of the physiological and biochemical properties of Beta vulgaris L. haploid lines". У CURRENT STATE, PROBLEMS AND PROSPECTS OF THE DEVELOPMENT OF AGRARIAN SCIENCE. Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea”, 2020. http://dx.doi.org/10.33952/2542-0720-2020-5-9-10-91.

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The aim of the work was to study the isoenzyme spectra of several lines of haploid regenerants of sugar beet in comparison with the parent forms in order to identify the most interesting ones for further selection. The donor material was the MS-form (malesterile form), haploid lines derived from it, as well as the fertile donor and its haploid lines.It was shown that the spectra of two enzymes − isocitrate dehydrogenase and malic enzyme are polymorphic, and the enzyme 6-phosphogluconate dehydrogenase is monomorphic and cannot be used in further selection.
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Iliushchenko, D. V., B. E. Efimenko, K. V. Gunbin, and K. Y. Popadin. "DEEP MUTATIONAL SPECTRUM OF MITOCHONDRIAL GENOME IN VERTEBRATES AS A NEW TYPE OF SPECIES — SPECIFIC MOLECULAR PHENOTYPE." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-4.

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The deep mutational spectrum (MS), an informative representation of de novo mutations with contextual data, offers valuable biological insights into the primary sources ofmutations across diverse genes, cancers, and species. However, reconstructing a comprehensive mutational spectrum demands substantial data, which is often lacking for non-model species. To address this challenge, we present a novel approach integrating sparse species-specific mitochondrial DNA (mtDNA) mutational spectra based on 122,031 polymorphic reconstructed synonymous mutations within the CytB gene of 974 vertebrate spec
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Rocha, José Claudio Casali da. "THE INFLUENCES OF ADHERENCE TO TAMOXIFEN AND CYP2D6 PHARMACOGENETICS ON PLASMA CONCENTRATIONS OF THE ACTIVE METABOLITE (Z)-ENDOXIFEN IN BREAST CANCER." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2025.

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Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)-endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (LC-MS/MS), adherence behavior (Morisky Medication Adherence Scale), and CYP2D6 and other pharmacogene polymorphisms (MALDI-TOF mass spectrometry and real-time PCR). Adherence explained 47% of the variability of tamoxifen plasma concentrations (p&lt;0.001). While CYP2D6 al
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Reports on the topic "Ms polymorphism"

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Levisohn, Sharon, Maricarmen Garcia, David Yogev, and Stanley Kleven. Targeted Molecular Typing of Pathogenic Avian Mycoplasmas. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695853.bard.

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Intraspecies identification (DNA "fingerprinting") of pathogenic avian mycoplasmas is a powerful tool for epidemiological studies and monitoring strain identity. However the only widely method available for Mycoplasma gallisepticum (MG) and M. synoviae (MS)wasrandom amplified polymorphic DNA (RAPD). This project aimed to develop alternative and supplementary typing methods that will overcome the major constraints of RAPD, such as the need for isolation of the organism in pure culture and the lack of reproducibility intrinsic in the method. Our strategy focussed on recognition of molecular mark
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Levisohn, Sharon, Mark Jackwood, and Stanley Kleven. New Approaches for Detection of Mycoplasma iowae Infection in Turkeys. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7612834.bard.

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Mycoplasma iowae (Mi) is a pathogenic avian mycoplasma which causes mortality in turkey embryos and as such has clinical and economic significance for the turkey breeder industry. Control of Mi infection is severely hampered by lack of adequate diagnostic tests, together with resistance to most antibiotics and resilience to environment. A markedly high degree of intra-species antigenic variation also contributes to difficulties in detection and control of infection. In this project we have designed an innovative gene-based diagnostic test based on specific amplification of the 16S rRNA gene of
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