Relevant bibliographies by topics / MSC

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'MSC'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "MSC"

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Peters, R. E., M. Heikenwälder, and A. Knuth. "Expansion of umbilical cord blood mesenchymal stem cells." Journal of Clinical Oncology 27, no. 15_suppl (2009): 7103. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.7103.

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7103 Background: Umbilical cord blood (UCB) is known to harbor 2 major types of stem cells, the hematopoietic stem cells (HSC) & the non-hematopoietic or mesenchymal stem cells (MSC). Under appropriate conditions, MSCs can give rise to cells of bone, fat, hepatic lineages, etc. Based on this potential, MSC hold promise for clinical applications in regenerative medicine. Methods: Stroma-free liquid culture: UCB cryopreserved mononuclear cells (MNC) were cultured in the presence of early growth factors: Flt-3 & SCF (25ng/ml), MGDF (10ng/ml) & human serum (10%). MNC derived adherent M
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Cequier, Alina, Antonio Romero, Francisco J. Vázquez, et al. "Equine Mesenchymal Stem Cells Influence the Proliferative Response of Lymphocytes: Effect of Inflammation, Differentiation and MHC-Compatibility." Animals 12, no. 8 (2022): 984. http://dx.doi.org/10.3390/ani12080984.

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Immunomodulation and immunogenicity are pivotal aspects for the therapeutic use of mesenchymal stem cells (MSCs). Since the horse is highly valuable as both a patient and translational model, further knowledge on equine MSC immune properties is required. This study analysed how inflammation, chondrogenic differentiation and compatibility for the major histocompatibility complex (MHC) influence the MSC immunomodulatory–immunogenicity balance. Equine MSCs in basal conditions, pro-inflammatory primed (MSC-primed) or chondrogenically differentiated (MSC-chondro) were co-cultured with either autolo
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Soland, Melisa, Mariana Bego, Christopher D. Porada, Esmail D. Zanjani, Stephen St Jeor, and Graca Almeida-Porada. "Modulation of Mesenchymal Stem Cell Immunogenicity through Forced Expression of Human Cytomegalovirus Proteins." Blood 112, no. 11 (2008): 2416. http://dx.doi.org/10.1182/blood.v112.11.2416.2416.

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Abstract Mesenchymal stem cells (MSC) are promising candidates for cell replacement therapy since they have the ability to differentiate, under appropriate conditions, into a broad range of specialized cell types. Furthermore, MSC have low inherent immunogenicity, immunomodulatory properties, and preferentially home to/engraft damaged tissues. However, they are not invisible to the immune system, and upon allogeneic transplantation, MSC can elicit an immune response, that results in activation of the recipient’s cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells and hence rejection of
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Laranjeira, Paula, Joana Gomes, Susana Pedreiro, et al. "Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells." Stem Cells International 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/819084.

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The immunosuppressive properties of mesenchymal stromal/stem cells (MSC) rendered them an attractive therapeutic approach for immune disorders and an increasing body of evidence demonstrated their clinical value. However, the influence of MSC on the function of specific immune cell populations, namely, monocyte subpopulations, is not well elucidated. Here, we investigated the influence of human bone marrow MSC on the cytokine and chemokine expression by peripheral blood classical, intermediate and nonclassical monocytes, and myeloid dendritic cells (mDC), stimulated with lipopolysaccharide plu
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Giallongo, Cesarina, Daniele Tibullo, Nunziatina Laura Parrinello, et al. "Mesenchymal Stem Cells (MSC) from Patients with Multiple Myeloma Promote Myeloid Cells to Become Granulocytic-Myeloid-Derived Suppressor Cells (G-MDSC) with Immunosuppressive, Bone Resorption and Pro-Angiogenic Activity." Blood 128, no. 22 (2016): 4458. http://dx.doi.org/10.1182/blood.v128.22.4458.4458.

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Abstract Purpose A well-recognized feature of MM is the intimate relationship between plasma cells and bone marrow microenvironment, which is mainly composed of MSC, endothelial cells, immune cells and extracellular matrix. G-MDSC accumulate in the tumor microenvironment during tumor development promoting tumor growth and immunosuppression. Aim Analyzing MSC from MGUS, Smoldering myeloma (SMM) and MM patients in promoting G-MDSC generation. Methods Human peripheral blood mononucleated cells (PBMC) isolated from healthy subjects (HS) were cultured alone and with HS- (n=10), MGUS- (n=10), SMM- (
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Maijenburg, Marijke, Marion Kleijer, Erik Mul, Floris van Alphen, Ellen van der Schoot, and Carlijn Voermans. "Primary Bone Marrow-Derived MSC Subsets with Distinct Wnt Expression Profiles Are Dynamically Distributed During Human Life." Blood 116, no. 21 (2010): 2590. http://dx.doi.org/10.1182/blood.v116.21.2590.2590.

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Abstract Abstract 2590 Mesenchymal stromal cells (MSC) in bone marrow (BM) consist of a heterogeneous population of cells. MSC orchestrate the BM microenvironment, and therefore have a pivotal role in hematopoietic support. Since MSC produce a large quantity and variety of Wnt proteins, it is likely that Wnts are involved in their hematopoietic support function Recent studies show enrichment for BM-derived MSC by sorting for CD271+ or CD146+ cells. However, it is unclear whether these markers are co-expressed with classical markers MSC markers CD73, CD105 and CD90. In addition mainly adult sam
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Robinson, Simon N., Paul J. Simmons, Nathalie Brouard, et al. "Efficacy of ‘Off-the-Shelf’, Commercially-Available, Third-Party Mesenchymal Stem Cells (MSC) in Ex Vivo Cord Blood (CB) Co-Culture Expansion." Blood 110, no. 11 (2007): 4106. http://dx.doi.org/10.1182/blood.v110.11.4106.4106.

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Abstract INTRODUCTION: Our previous studies have shown that clinically-relevant levels of hematopoietic stem and progenitor cell (HSPC) expansion are possible by ex vivo co-culture of cord blood (CB) mononuclear cells (MNC) with third-party bone marrow (BM)-derived mesenchymal stem cells (MSC) and growth factors.1 A recently activated M. D. Anderson protocol requires that BM from a haplo-identical family member be used for the de novo generation of sufficient MSC for subsequent co-culture, a process requiring ∼3 weeks. Time constraints, uncertainties associated with the identification of a sui
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Salgar, Shashikumar K., E. Manning, S. Li, et al. "Interleukin-10 delivery via mesenchymal stem cells (MSC) to prevent ischemia/reperfusion injury in lung transplantation (141.46)." Journal of Immunology 182, no. 1_Supplement (2009): 141.46. http://dx.doi.org/10.4049/jimmunol.182.supp.141.46.

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Abstract Ischemia-reperfusion injury (IR) is an important cause for lung graft loss (~30%). In this study, MSC & viral interleukin-10 (vIL-10) engineered MSC were tested for their ability to prevent lung IR injury. Bone marrow derived MSC from Lewis rat were transduced with rvIL-10-retrovirus & selected on neomycin. Following 120 min of left lung ischemia induction, Group A, rats received vIL-10-MSC (~15 x 106; i.v.); Group B, empty vector engineered MSC; Group C, MSC; Group D, saline; and Group E, no ischemia or MSC. Mean blood oxygenation (PaO2/FiO2 ratio, mmHg) was reduced (P&lt
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Giallongo, Cesarina, Nunziatina L. Parrinello, Daniele Tibullo, et al. "Mesenchymal STEM CELLS Favor Tumor Growth By Generating Granulocyte-like Myeloid Derived Suppressor CELLS in CML Patients." Blood 126, no. 23 (2015): 4018. http://dx.doi.org/10.1182/blood.v126.23.4018.4018.

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Abstract INTRODUCTION. The complex interplay between cancer cells and immune system allows neoplastic cells to evade immune surveillance and expand. Recently, our and another group have demonstrated that a subpopulation of myeloid cells, defined as "granulocytic myeloid-derived suppressor cells" (G-MDSC), plays an important role for immune escape in chronic myeloid leukemia (CML) patients by reducing T cell activation. The aim of this study was to evaluate the influence of Mesenchymal stem cells (MSC) on generation of MDSCs by comparing CML MSCs (n=10) with healthy donors (HD) MSC (n=8). METHO
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Salgar, Shashikumar, S. Li, M. Hernandez, et al. "Recipient Conditioning with Mesenchymal Stem Cells and Interleukin-10 Prolonged Cardiac Allograft Survival (102.1)." Journal of Immunology 178, no. 1_Supplement (2007): S204. http://dx.doi.org/10.4049/jimmunol.178.supp.102.1.

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Abstract Mesenchymal Stem Cells (MSC) and viral interleukin-10 (vIL-10) have immunosuppressive properties. In this study, we tested their ability to prevent cardiac allograft rejection. Bone marrow derived MSC from Lewis rat were expanded ex vivo and transduced with rvIL-10-retrovirus. Autologous MSC or vIL-10 transduced MSC were injected (~25 x 106; i.v.) into irradiated (4 Gy) rat (RT1.Al). Six weeks later heterotopic heart (RT1.An) transplantation (Tx) was performed. MSC therapy prolonged (P<0.05) cardiac allograft survival (14±1 days; n= 4) compared to untreated controls (7±1 days;
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Dissertations / Theses on the topic "MSC"

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Comaga, Kerim. "MSc Architecture." Thesis, KTH, Arkitektur, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298483.

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This project has revolved around how to expand Stockholm in socially sustainable way. As is the case with many other cities in the world, inspired by modernist ideals, expansion during the 1900: s have shaped Stockholm into an archipelago of islands with mostly homogenous housing types that exist within an urban structure of centre and periphery. The Stockholm City Council is trying counter this situation by expanding the city centre into eight new regional cores by densifying a few chosen areas. This is done by conforming to old traditions of placing existing housing types and public spaces i
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Weber, Sérgio. "ASPE/MSC." Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102368.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação<br>Made available in DSpace on 2013-07-16T00:46:12Z (GMT). No. of bitstreams: 1 224905.pdf: 5536445 bytes, checksum: 9c37dced0f425adf455a3f6d0fa8b466 (MD5)<br>Segundo dados do ministério da ciência e tecnologia (MCT), o mercado brasileiro na área de software é composto predominantemente por micro e pequenas empresas (MPEs), cujos processos são executados geralmente de modo informal, improvisado e com pouca visibilidade. Esse cenário gera uma série de dificulda
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Jentsch, Lothar, and David Natroshvili. "Three-dimensional mathematical Problems of thermoelasticity of anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800967.

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CHAPTER I. Basic Equations. Fundamental Matrices. Thermo-Radiation Conditions 1. Basic differential equations of thermoelasticity theory 2. Fundamental matrices 3. Thermo-radiating conditions. Somigliana type integral representations CHAPTER II. Formulation of Boundary Value and Interface Problems 4. Functional spaces 5. Formulation of basic and mixed BVPs 6. Formulation of crack type problems 7. Formulation of basic and mixed interface problems CHAPTER III. Uniqueness Theorems 8. Uniqueness theorems in pseudo-oscillation problems 9. Uniqueness theorems in steady state oscillation problems
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Jentsch, L., D. Natroshvili, and I. Sigua. "Mixed Interface Problems of Thermoelastic Pseudo-Oscillations." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801150.

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Three-dimensional basic and mixed interface problems of the mathematical theory of thermoelastic pseudo-oscillations are considered for piecewise homogeneous anisotropic bodies. Applying the method of boundary potentials and the theory of pseudodifferential equations existence and uniqueness theorems of solutions are proved in the space of regular functions C^(k+ alpha) and in the Bessel-potential (H^(s)_(p)) and Besov (B^(s)_(p,q)) spaces. In addition to the classical regularity results for solutions to the basic interface problems, it is shown that in the mixed interface problems the displac
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Jentsch, L., and D. Natroshvili. "Interaction between Thermoelastic and Scalar Oscillation Fields (general anisotropic case)." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801162.

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Three-dimensional mathematical problems of the interaction between thermoelastic and scalar oscillation fields are considered in a general anisotropic case. An elastic structure is assumed to be a bounded homogeneous anisortopic body occupying domain $\Omega^+\sub\R^3$ , where the thermoelastic field is defined, while in the physically anisotropic unbounded exterior domain $\Omega^-=\R^3\\ \overline{\Omega^+}$ there is defined the scalar field. These two fields satisfy the differential equations of steady state oscillations in the corresponding domains along with the transmission conditions
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Jentsch, L., and D. Natroshvili. "Thermoelastic Oscillations of Anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800871.

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The generalized radiation conditions at infinity of Sommerfeld-Kupradze type are established in the theory of thermoelasticity of anisotropic bodies. Applying the potential method and the theory of pseudodifferential equations on manifolds the uniqueness and existence theorems of solutions to the basic three-dimensional exterior boundary value problems are proved and representation formulas of solutions by potential type integrals are obtained.
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Jung, M., and U. Rüde. "Implicit extrapolation methods for multilevel finite element computations." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800516.

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Extrapolation methods for the solution of partial differential equations are commonly based on the existence of error expansions for the approximate solution. Implicit extrapolation, in the contrast, is based on applying extrapolation indirectly, by using it on quantities like the residual. In the context of multigrid methods, a special technique of this type is known as \034 -extrapolation. For finite element systems this algorithm can be shown to be equivalent to higher order finite elements. The analysis is local and does not use global expansions, so that the implicit extrapolation techniq
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Natroshvili, David, and Shota Zazashvili. "The Interface Crack Problem for Anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800979.

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The two-dimensional interface crack problem is investigated for anisotropic bodies in the Comninou formulation. It is established that, as in the isotropic case, properly incorporating contact zones at the crack tips avoids contradictions connected with the oscillating asymptotic behaviour of physical and mechanical characteristics leading to the overlapping of material. Applying the special integral representation formulae for the displacement field the problem in question is reduced to the scalar singular integral equation with the index equal to -1. The analysis of this equation is given.
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Coquery, Nicolas [Verfasser]. "Intrahippocampal transplantation of MSC and MSC-expressing BDNF in Rat Models of Depression-like Behaviour / Nicolas Coquery." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023665360/34.

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Leonard, Martha Maria. "A description of final year nursing students' ability to recognize abnormal vital signs recordings and clinical decision-making process." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/6663.

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Includes abstract.<br>Includes bibliographical references.<br>The aim of this study was to determine whether final year nursing students can recognize and respond to abnormal vital sign recordings, and to analyse their clinical decision-making processes.
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Books on the topic "MSC"

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Great Britain. Central Research Administration Unit., ed. MSC research. Manpower Services Commission, Central Research Administration Unit, 1985.

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Cifuentes, Arturo O. Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0.

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Corporation, MacNeal-Schwendler, ed. MSC/NASTRAN bibliography. 2nd ed. MacNeal-Schwendler Corp., 1993.

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Corporation, MacNeal Schwender, ed. MSC/NASTRAN bibliography. 2nd ed. MacNeal-Schwendler Corp, 1993.

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TVEI-related In-Service Training for Teachers., ed. MSC summative report. TVEI Unit, 1987.

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Sutherland, M. Msc databases and networks. University of East London, 1994.

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Science, Brunel University Department of Computer. Exam papers: MSc, 1990. Brunel University, 1990.

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Great Britain. Manpower Services Commission. Central Research Administration Unit. MSC research 1985/86. the Commission, 1986.

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Brunel University. Department of mechanical engineering. Exam papers: MSc 1993. Brunel University, 1993.

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Randall, Colin. MSC: Good for business? Centre for a Working World, 1987.

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Book chapters on the topic "MSC"

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Vogel, Burkhard. "Miscellaneous (MSC)." In How to Gain Gain. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-33033-9_34.

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Murthy, D. N. P., and Nat Jack. "EW/MSC Processes." In Springer Series in Reliability Engineering. Springer London, 2014. http://dx.doi.org/10.1007/978-1-4471-6440-1_6.

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Lohrey, Markus, and Anca Muscholl. "Bounded MSC Communication." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-45931-6_21.

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Biala, Jacek. "BSS-MSC-Schnittstelle." In Mobilfunk und Intelligente Netze. Vieweg+Teubner Verlag, 1996. http://dx.doi.org/10.1007/978-3-322-87270-8_11.

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Biala, Jacek. "BSS-MSC-Schnittstelle." In Mobilfunk und Intelligente Netze. Vieweg+Teubner Verlag, 1994. http://dx.doi.org/10.1007/978-3-322-83660-1_11.

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Cifuentes, Arturo O. "Introduction." In Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0_1.

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Cifuentes, Arturo O. "Problem 9." In Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0_10.

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Cifuentes, Arturo O. "Problem 10." In Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0_11.

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Cifuentes, Arturo O. "Problem 11." In Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0_12.

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Cifuentes, Arturo O. "Problem 12." In Using MSC/NASTRAN. Springer New York, 1989. http://dx.doi.org/10.1007/978-1-4613-8917-0_13.

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Conference papers on the topic "MSC"

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Coughlin, Thomas R., Matthew Haugh, Muriel Voisin, Evelyn Birmingham, Laoise M. McNamara, and Glen L. Niebur. "Primary Cilia Knockdown Reduces the Number of Stromal Cells in Three Dimensional Ex Vivo Culture." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14723.

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Mesenchymal stem cells (MSCs) are multipotent stromal cells that reside in the bone marrow and differentiate into connective cell lines, such as adipocytes and osteoblasts [1]. An appropriate balance of MSC differentiation toward adipocytes and osteoblasts is vital to bone homeostasis [6]. In vitro work demonstrates that differentiation of MSCs is influenced by mechanical stimuli [2, 3]. In a mouse model, the ratio of adipocytes to MSCs in the marrow was 19% lower compared to controls following treatment by low magnitude mechanical signals (LMMS) [4]. In mice, LMMS increased MSC number by 46%
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Huang, Alice H., and Robert L. Mauck. "Repeated Dynamic Loading Modulates Cartilage Gene Expression but Does Not Improve Mechanical Properties of MSC-Laden Hydrogels." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204339.

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Mesenchymal stem cells (MSCs) are a multi-potential cell type that can differentiate toward a variety of tissue-specific phenotypes, including cartilage. Given their chondrogenic potential, MSCs are a promising cell source for cartilage tissue engineering (TE). However, while MSCs readily undergo chondrogenesis in 3D culture and deposit a cartilage-like matrix, the mechanical properties of MSC-seeded constructs are greatly inferior to chondrocyte-seeded constructs similarly maintained [1]. To date, optimization strategies for enhancing functional MSC chondrogenesis, including increasing seedin
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Wingate, Kathryn, Yan Tan, and Wei Tan. "The Effects of Mechanical and Chemical Stimuli on Mesenchymal Stem Cell Vascular Trans-Differentiation and Paracrine Signaling." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14742.

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Mesenchymal Stem Cells (MSCs) show great promise for the treatment of cardiovascular diseases by tissue engineering and cell therapy. MSCs are particularly useful for vascular therapies as they are easily obtainable, allogenic, trans-differentiate into specific vascular cells, and assist in regenerating vascular tissue through paracrine signaling. [1] However, the mechanisms which direct MSC trans-differentiation and paracrine signaling are not well defined. [2] Incorrect differentiation of MSC can lead to catastrophic side effects such as the development of a dysfunctional endothelium. [3] To
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Barminko, Jeffrey, Jean Pierre Dolle, Rene Schloss, Martin Grumet, and Martin L. Yarmush. "Encapsulated Mesenchymal Stem Cells for Central Nervous System Repair." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19712.

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Mesenchymal stromal cells (MSC) have long been regarded as a cell source with the potential to provide therapies for various different tissue pathologies. They were originally identified for their ability to adhere to tissue culture plastic and gained favor due to their tremendous ability to propagate[1]. It was this finding as well as their ability to differentiate into lineages of mesoderm which have long made MSC a potential tool for autologous cellular replacement therapies [2, 3]. More recently, their cyto-protective role has been realized and been implicated in the benefit achieved in tr
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Metzger, Thomas A., Stephen A. Schwaner, and Glen L. Niebur. "Pressure Gradients in the Trabecular Pore Space of Femurs During Physiologic Loading." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14433.

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Bone marrow is an important niche for mesenchymal stromal cells (MSCs), which are progenitors for connective tissue cells. MSCs respond to mechanical stimuli (1). For example, steady and oscillatory fluid flow both affect MSC differentiation to the osteogenic lineages (2), while hydrostatic pressure increases MSC osteogenic protein expression (3). Both pressure and fluid flow are induced in bone marrow during loading due to the poroelastic nature of trabecular bone, and these may affect the differentiation or proliferation of the resident stromal cells.
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Huang, Alice H., and Robert L. Mauck. "Extended Long-Term Culture of MSC-Laden Agarose Constructs Does Not Produce Functional Tissue Comparable to Primary Chondrocytes." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19643.

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Articular cartilage lines the surfaces of joints and transmits the forces arising from locomotion. The poor ability of cartilage to self-repair has motivated efforts to engineer replacements that recapitulate this load-bearing function. While chondrocyte-laden constructs have been generated with near-native mechanical properties, limitations in chondrocyte availability may preclude their clinical use. Therefore, mesenchymal stem cells (MSCs), which can undergo chondrogenesis in 3D culture, have emerged as a promising alternative [1]. However, although MSCs deposit a cartilaginous matrix, mecha
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Kulebyakina, M. A., D. A. Butuzova, N. D. Basalova, and A. Yu Efimenko. "DKK3 SECRETED BY MESENCHYMAL STROMAL CELLS PREVENTS FIBROBLAST-TO-MYOFIBROBLAST TRANSITION." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-287.

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It is well known that mesenchymal stromal cells (MSCs) prevent the development of fibrosis in a paracrine manner; still, the underlying mechanisms have not yet been studied. Using proteomic analysis, we identified the DKK3 protein, a regulator of the Wnt signaling pathway, in the MSC secretome. We also demonstrated that the DKK3 protein in the MSC secretome suppresses the canonical Wnt signaling pathway in fibroblasts and prevents myofibroblast differentiation.
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Farrell, Megan J., John Shin, and Robert L. Mauck. "Functional Consequences of Glucose and Oxygen Deprivation in Engineered MSC-Based Cartilage Constructs." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14495.

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Clinical implementation of stem cell-based cartilage repair techniques has been limited by the inability of these cells to produce cartilaginous tissue equivalent to that produced by native chondrocytes. We have recently shown that while bulk mechanical properties of mesenchymal stem cell (MSC)-laden constructs are lower than chondrocyte-laden constructs, MSCs can in fact produce tissue that matches or exceeds the biochemical and mechanical properties produced by chondrocytes in regions where there is maximal nutrient supply [1]. We also noted that in the central regions of constructs, where n
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Kim, Minwook, Jason A. Burdick, and Robert L. Mauck. "Influence of Chondrocyte Zone on Co-Cultures With Mesenchymal Stem Cells in HA Hydrogels for Cartilage Tissue Engineering." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80859.

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Mesenchymal stem cells (MSCs) are an attractive cell type for cartilage tissue engineering in that they can undergo chondrogenesis in a variety of 3D contexts [1]. Focused efforts in MSC-based cartilage tissue engineering have recently culminated in the formation of biologic materials possessing biochemical and functional mechanical properties that match that of the native tissue [2]. These approaches generally involve the continuous or intermittent application of pro-chondrogenic growth factors during in vitro culture. For example, in one recent study, we showed robust construct maturation in
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Wingate, Kathryn, Yan Tan, Raphael Nemenoff, and Wei Tan. "Combined Effects of Nanofiber Matrix Elasticity and VEGF-A on the Differentiation of Mesenchymal Stem Cells Towards Mature Endothelial Cells." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80747.

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The potential of mesenchymal stem cell (MSC) in the treatment of vascular diseases is becoming increasingly recognized.[1] The use of MSC to produce a functional endothelium in synthetic vascular grafts is of particular interest as this would prevent common graft failures such as neointima hyperplasia and thrombus. Current attempts to produce a functional endothelial layer with endothelial cells (EC) have limited success due to the need for invasive surgery and the limited expansion capability these cells have in vitro.[2] MSC are a powerful cellular alternative as they are easily obtained thr
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Reports on the topic "MSC"

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Herman, Michal, and Kawano Toshihiko. Problem with gradual absorption in MSD/MSC calculations. Office of Scientific and Technical Information (OSTI), 2023. http://dx.doi.org/10.2172/2377303.

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Carr, Randolf, and Nicole Koenig. Debrief MSC 2024. Munich Security Conference, 2024. http://dx.doi.org/10.47342/hiqv3321.

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Carr, Randolf, and Nicole Koenig. Debrief MSC 2024 German Version. Munich Security Conference, 2024. http://dx.doi.org/10.47342/ixxf9801.

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Hawley, Daniel P. Command and Control of MSC Shipping. Defense Technical Information Center, 1996. http://dx.doi.org/10.21236/ada307349.

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S. Drummond. CASK/MSC/WP PREPARATION SYSTEM DESCRIPTION DOCUMENT. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/841281.

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Cörvers, Frank, Arnold Hendrikse, and Sanne Steens. Macrodoelmatigheid MSc Crop Biotechnology and Engineering (CBE). ROA, 2022. http://dx.doi.org/10.26481/umarot.2022002.

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Zarrieß, Benjamin, and Anni-Yasmin Turhan. Most Specific Generalizations w.r.t. General EL-TBoxes. Technische Universität Dresden, 2013. http://dx.doi.org/10.25368/2022.196.

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In the area of Description Logics the least common subsumer (lcs) and the most specific concept (msc) are inferences that generalize a set of concepts or an individual, respectively, into a single concept. If computed w.r.t. a general EL-TBox neither the lcs nor the msc need to exist. So far in this setting no exact conditions for the existence of lcs- or msc-concepts are known. This report provides necessary and suffcient conditions for the existence of these two kinds of concepts. For the lcs of a fixed number of concepts and the msc we show decidability of the existence in PTime and polynom
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Hua, Zi Bo, and Lv Yuan Chen. Human UCB MSC versus placebo for effect on kidney fibrosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0104.

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Review question / Objective: Human UCB MSC versus placebo for effect on kidney fibrosis Condition being studied: Renal fibrosis is the final outcome of long-term chronic kidney disease, and the kidney will lose its basic function. This experiment will explore the effect of Human UCB MSC for effect on kidney fibrosis. Main outcome(s): Correlation analysis of Human UCB MSC treatment on renalfibrosis.
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Küsters, Ralf, and Ralf Molitor. Computing Most Specific Concepts in Description Logics with Existential Restrictions. Aachen University of Technology, 2000. http://dx.doi.org/10.25368/2022.108.

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Computing the most specific concept (msc) is an inference task that can be used to support the 'bottom-up' construction of knowledge bases for KR systems based on description logics. For description logics that allow for number restrictions or existential restrictions, the msc need not exist, though. Previous work on this problem has concentrated on description logics that allow for universal value restrictions and number restrictions, but not for existential restrictions. The main new contribution of this paper is the treatment of description logics with existential restrictions. More precise
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Baader, Franz. A Graph-Theoretic Generalization of the Least Common Subsumer and the Most Specific Concept in the Description Logic EL. Technische Universität Dresden, 2004. http://dx.doi.org/10.25368/2022.139.

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In two previous papers we have investigates the problem of computing the least common subsumer (lcs) and the most specific concept (msc) for the description logic EL in the presence of terminological cycles that are interpreted with descriptive semantics, which is the usual first-order semantics for description logics. In this setting, neither the lcs nor the msc needs to exist. We were able to characterize the cases in which the lcs/msc exists, but it was not clear whether this characterization yields decidability of the existence problem. In the present paper, we develop a common graph-theor
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