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Journal articles on the topic 'MSC'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Peters, R. E., M. Heikenwälder, and A. Knuth. "Expansion of umbilical cord blood mesenchymal stem cells." Journal of Clinical Oncology 27, no. 15_suppl (2009): 7103. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.7103.

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7103 Background: Umbilical cord blood (UCB) is known to harbor 2 major types of stem cells, the hematopoietic stem cells (HSC) & the non-hematopoietic or mesenchymal stem cells (MSC). Under appropriate conditions, MSCs can give rise to cells of bone, fat, hepatic lineages, etc. Based on this potential, MSC hold promise for clinical applications in regenerative medicine. Methods: Stroma-free liquid culture: UCB cryopreserved mononuclear cells (MNC) were cultured in the presence of early growth factors: Flt-3 & SCF (25ng/ml), MGDF (10ng/ml) & human serum (10%). MNC derived adherent M

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Cequier, Alina, Antonio Romero, Francisco J. Vázquez, et al. "Equine Mesenchymal Stem Cells Influence the Proliferative Response of Lymphocytes: Effect of Inflammation, Differentiation and MHC-Compatibility." Animals 12, no. 8 (2022): 984. http://dx.doi.org/10.3390/ani12080984.

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Immunomodulation and immunogenicity are pivotal aspects for the therapeutic use of mesenchymal stem cells (MSCs). Since the horse is highly valuable as both a patient and translational model, further knowledge on equine MSC immune properties is required. This study analysed how inflammation, chondrogenic differentiation and compatibility for the major histocompatibility complex (MHC) influence the MSC immunomodulatory–immunogenicity balance. Equine MSCs in basal conditions, pro-inflammatory primed (MSC-primed) or chondrogenically differentiated (MSC-chondro) were co-cultured with either autolo

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Soland, Melisa, Mariana Bego, Christopher D. Porada, Esmail D. Zanjani, Stephen St Jeor, and Graca Almeida-Porada. "Modulation of Mesenchymal Stem Cell Immunogenicity through Forced Expression of Human Cytomegalovirus Proteins." Blood 112, no. 11 (2008): 2416. http://dx.doi.org/10.1182/blood.v112.11.2416.2416.

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Abstract Mesenchymal stem cells (MSC) are promising candidates for cell replacement therapy since they have the ability to differentiate, under appropriate conditions, into a broad range of specialized cell types. Furthermore, MSC have low inherent immunogenicity, immunomodulatory properties, and preferentially home to/engraft damaged tissues. However, they are not invisible to the immune system, and upon allogeneic transplantation, MSC can elicit an immune response, that results in activation of the recipient’s cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells and hence rejection of

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Laranjeira, Paula, Joana Gomes, Susana Pedreiro, et al. "Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells." Stem Cells International 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/819084.

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The immunosuppressive properties of mesenchymal stromal/stem cells (MSC) rendered them an attractive therapeutic approach for immune disorders and an increasing body of evidence demonstrated their clinical value. However, the influence of MSC on the function of specific immune cell populations, namely, monocyte subpopulations, is not well elucidated. Here, we investigated the influence of human bone marrow MSC on the cytokine and chemokine expression by peripheral blood classical, intermediate and nonclassical monocytes, and myeloid dendritic cells (mDC), stimulated with lipopolysaccharide plu

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Giallongo, Cesarina, Daniele Tibullo, Nunziatina Laura Parrinello, et al. "Mesenchymal Stem Cells (MSC) from Patients with Multiple Myeloma Promote Myeloid Cells to Become Granulocytic-Myeloid-Derived Suppressor Cells (G-MDSC) with Immunosuppressive, Bone Resorption and Pro-Angiogenic Activity." Blood 128, no. 22 (2016): 4458. http://dx.doi.org/10.1182/blood.v128.22.4458.4458.

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Abstract Purpose A well-recognized feature of MM is the intimate relationship between plasma cells and bone marrow microenvironment, which is mainly composed of MSC, endothelial cells, immune cells and extracellular matrix. G-MDSC accumulate in the tumor microenvironment during tumor development promoting tumor growth and immunosuppression. Aim Analyzing MSC from MGUS, Smoldering myeloma (SMM) and MM patients in promoting G-MDSC generation. Methods Human peripheral blood mononucleated cells (PBMC) isolated from healthy subjects (HS) were cultured alone and with HS- (n=10), MGUS- (n=10), SMM- (

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Maijenburg, Marijke, Marion Kleijer, Erik Mul, Floris van Alphen, Ellen van der Schoot, and Carlijn Voermans. "Primary Bone Marrow-Derived MSC Subsets with Distinct Wnt Expression Profiles Are Dynamically Distributed During Human Life." Blood 116, no. 21 (2010): 2590. http://dx.doi.org/10.1182/blood.v116.21.2590.2590.

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Abstract Abstract 2590 Mesenchymal stromal cells (MSC) in bone marrow (BM) consist of a heterogeneous population of cells. MSC orchestrate the BM microenvironment, and therefore have a pivotal role in hematopoietic support. Since MSC produce a large quantity and variety of Wnt proteins, it is likely that Wnts are involved in their hematopoietic support function Recent studies show enrichment for BM-derived MSC by sorting for CD271+ or CD146+ cells. However, it is unclear whether these markers are co-expressed with classical markers MSC markers CD73, CD105 and CD90. In addition mainly adult sam

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Robinson, Simon N., Paul J. Simmons, Nathalie Brouard, et al. "Efficacy of ‘Off-the-Shelf’, Commercially-Available, Third-Party Mesenchymal Stem Cells (MSC) in Ex Vivo Cord Blood (CB) Co-Culture Expansion." Blood 110, no. 11 (2007): 4106. http://dx.doi.org/10.1182/blood.v110.11.4106.4106.

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Abstract INTRODUCTION: Our previous studies have shown that clinically-relevant levels of hematopoietic stem and progenitor cell (HSPC) expansion are possible by ex vivo co-culture of cord blood (CB) mononuclear cells (MNC) with third-party bone marrow (BM)-derived mesenchymal stem cells (MSC) and growth factors.1 A recently activated M. D. Anderson protocol requires that BM from a haplo-identical family member be used for the de novo generation of sufficient MSC for subsequent co-culture, a process requiring ∼3 weeks. Time constraints, uncertainties associated with the identification of a sui

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Salgar, Shashikumar K., E. Manning, S. Li, et al. "Interleukin-10 delivery via mesenchymal stem cells (MSC) to prevent ischemia/reperfusion injury in lung transplantation (141.46)." Journal of Immunology 182, no. 1_Supplement (2009): 141.46. http://dx.doi.org/10.4049/jimmunol.182.supp.141.46.

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Abstract Ischemia-reperfusion injury (IR) is an important cause for lung graft loss (~30%). In this study, MSC & viral interleukin-10 (vIL-10) engineered MSC were tested for their ability to prevent lung IR injury. Bone marrow derived MSC from Lewis rat were transduced with rvIL-10-retrovirus & selected on neomycin. Following 120 min of left lung ischemia induction, Group A, rats received vIL-10-MSC (~15 x 106; i.v.); Group B, empty vector engineered MSC; Group C, MSC; Group D, saline; and Group E, no ischemia or MSC. Mean blood oxygenation (PaO2/FiO2 ratio, mmHg) was reduced (P&lt

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Giallongo, Cesarina, Nunziatina L. Parrinello, Daniele Tibullo, et al. "Mesenchymal STEM CELLS Favor Tumor Growth By Generating Granulocyte-like Myeloid Derived Suppressor CELLS in CML Patients." Blood 126, no. 23 (2015): 4018. http://dx.doi.org/10.1182/blood.v126.23.4018.4018.

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Abstract INTRODUCTION. The complex interplay between cancer cells and immune system allows neoplastic cells to evade immune surveillance and expand. Recently, our and another group have demonstrated that a subpopulation of myeloid cells, defined as "granulocytic myeloid-derived suppressor cells" (G-MDSC), plays an important role for immune escape in chronic myeloid leukemia (CML) patients by reducing T cell activation. The aim of this study was to evaluate the influence of Mesenchymal stem cells (MSC) on generation of MDSCs by comparing CML MSCs (n=10) with healthy donors (HD) MSC (n=8). METHO

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Salgar, Shashikumar, S. Li, M. Hernandez, et al. "Recipient Conditioning with Mesenchymal Stem Cells and Interleukin-10 Prolonged Cardiac Allograft Survival (102.1)." Journal of Immunology 178, no. 1_Supplement (2007): S204. http://dx.doi.org/10.4049/jimmunol.178.supp.102.1.

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Abstract Mesenchymal Stem Cells (MSC) and viral interleukin-10 (vIL-10) have immunosuppressive properties. In this study, we tested their ability to prevent cardiac allograft rejection. Bone marrow derived MSC from Lewis rat were expanded ex vivo and transduced with rvIL-10-retrovirus. Autologous MSC or vIL-10 transduced MSC were injected (~25 x 106; i.v.) into irradiated (4 Gy) rat (RT1.Al). Six weeks later heterotopic heart (RT1.An) transplantation (Tx) was performed. MSC therapy prolonged (P&lt;0.05) cardiac allograft survival (14±1 days; n= 4) compared to untreated controls (7±1 days;

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Lane, Thomas A., Davina Garls, Ellen Mackintosh, Sanjivan Kohli, and Steven C. Cramer. "Feasibility of Rapidly Generating Sufficient Autologous Human Marrow Stromal Cells for Cellular Therapy." Blood 110, no. 11 (2007): 1218. http://dx.doi.org/10.1182/blood.v110.11.1218.1218.

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Abstract Marrow stromal cells (MSC) are increasingly employed for human cellular therapy protocols. In some cases, it may be advantageous to use autologous MSC, but the feasibility of quickly generating sufficient MSC for autologous therapy has not been established. We investigated the feasibility of rapidly generating large numbers of autologous, early passage, MSC as a prerequisite for the clinical investigation of MSC in human ischemic stroke. Bone marrow (25–35 mL) was collected from 8 healthy volunteers under an IRB-approved protocol; a mononuclear cell (mnc) fraction prepared by ficol de

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Jarocha, Danuta, Ewa Lesko, Mariusz Z. Ratajczak, and Marcin Majka. "Comparison of Different Strategies of MSC Isolation Revels Advantage To Expand MSC Directly from Purified CD105+ and CD271+ Cells." Blood 108, no. 11 (2006): 2566. http://dx.doi.org/10.1182/blood.v108.11.2566.2566.

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Abstract The potential for multilineage differentiation together with the ability to expand in cultures are the reasons why Mesenchymal Stem Cells (MSC) are considered to be the population of stem cells for potential treatment for variety of disorders (e. g. Osteogenesis Imperfecta, Myocardium Infarction, GvHD). MSC are isolated from the bone marrow mononuclear cells (MNC) based on their adhesive properties. There have been few attempts to isolate MSC directly based on the expression of selected surface antigens, but these isolation strategies were not compared with “the gold standard” procedu

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Tang, Katherine C., Sergei Kotenko, Jonathan S. Harrison, and Pranela Rameshwar. "IFNg-Mediated MHC-II Expression in Mesenchymal Stem Cells (MSC) Is Concentration-Dependent." Blood 104, no. 11 (2004): 4250. http://dx.doi.org/10.1182/blood.v104.11.4250.4250.

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Abstract A significant concern in tissue repair is allo-rejection in a host with MHC-II mismatch. Since MSC appear to have veto properties to offset its own rejection, these stem cells may serve as ideal candidates in repair medicine. Interferon-g (IFN-g), which exacerbates immune responses, is known to enhance the expression of MHC-II in antigen presenting cells (e.g., macrophages). This led to the question on the mechanism by which MSC act as immune suppressor cells. We hypothesize that endogenous IFN-γ maintains basal MHC-II expression, while increased levels lead to its down regulation. In

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Menard, Cedric, Luciano Pacelli, Giulio Bassi, et al. "Quality Controls Of Immune Regulatory Properties Of Ex-Vivo, GMP-Grade Expanded Mesenchymal Stromal Cells For Clinical Use." Blood 122, no. 21 (2013): 5413. http://dx.doi.org/10.1182/blood.v122.21.5413.5413.

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Abstract Aim of CASCADE is to standardize GMP-grade production and clinical use of Mesenchymal Stromal Cells (MSC). Immunological Unit is aimed at setting up and validating a standardized panel of functional assays to fully characterize the immunomodulatory properties of MSC obtained from bone marrow and adipose tissue through different GMP-grade expansion protocols (platelet lysate- vs. fetal calf serum). Immune cells were isolated using indirect immunomagnetic depletion (purity >96%). MSC were expanded in the same medium used for production and harvested at 70% confluence. Primed MSC (pMS

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Vinci, Paola, Antonio Bastone, Silvia Schiarea, et al. "Chemerin Produced By Mesenchymal Stromal Cells (MSC) Is an Important Factor for In Vivo macrophage Migration." Blood 126, no. 23 (2015): 1195. http://dx.doi.org/10.1182/blood.v126.23.1195.1195.

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Abstract Mesenchymal Stromal Cells (MSC) are multipotent cells currently used for treating several inflammatory disorders thanks to their ability to modulate the immune response. However, the mechanisms by which MSC are able to suppress the immune response have not been fully understood. Chemerin has been recently identified as a chemotactic protein, secreted as a precursor, named Prochemerin, and converted into its active form through the proteolitic cleavage of the last six-seven amino acids at the C-terminal domain by different serine and cysteine proteases derived from the fibrinolitic, co

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Poggi, Alessandro, Anna-Maria Massaro, Simone Negrini, et al. "Evidence for Killing of Mesenchymal Stem Cells (MSC) by Autologous Natural Killer Lymphocytes." Blood 104, no. 11 (2004): 1290. http://dx.doi.org/10.1182/blood.v104.11.1290.1290.

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Abstract In this study, Mesenchymal Stem Cells (MSC) were obtained from bone marrow of 10 patients suffering from acute myeloid leukemia (AML), six M0/1 two M2, and two M5 (according to the FAB classification), 8 out of 10 in post-chemotherapy complete remission. These cells differentiated into adipocytes or osteoblasts under appropriate culture conditions. MSC were CD44+, CD73a+ CD73b+ CD105+, beta1 integrin+, ICAM1+, HLA-I+, HLA-II+ (variable proportions), CD45−, CD31−, CD34− and they constitutively expressed the stress-inducible MHC-related molecules MIC-A and the UL16 (induced at the surfa

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Mohammad Kurniawan, Yetty Ramli, Teguh A S Ranakusuma, et al. "Mesenchymal and mononuclear stem cell therapy for acute ischemic stroke - A systematic review." Neurology Asia 28, no. 4 (2023): 857–66. http://dx.doi.org/10.54029/2023ahd.

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Background: Studies have shown that stem cells have promising effect in ischemic stroke management. As an alternative therapy, the effectiveness and safety of mesenchymal (MSC) and mononuclear (MNC) stem cells in acute stroke are still unclear. This review evaluated the efficacy and safety of the use of MSC and MNC in acute ischemic stroke in terms of clinical and structural improvement. Methods: This is a systematic review which is conducted based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline. Our review focused on RCT, with acute ischemic strok

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MAROLI, SREE LAKSHMI VELANDI, Touhidul Molla, Peter Llontop, and Tzvia Abramson. "mBM-Mesenchymal Stem Cells as a vehicle for immunization of mice against Bordetella pertussis." Journal of Immunology 198, no. 1_Supplement (2017): 147.21. http://dx.doi.org/10.4049/jimmunol.198.supp.147.21.

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Abstract Mesenchymal Stem Cells (MSC) derived from bone marrow is well documented to lack immunogenic features and demonstrate anti-inflammatory characteristics. Additionally, in vitro treatment of MSCs with IFNγ was previously shown to increase expression of antigen-presenting molecules such as MHC class II. Therefore in this study, we hypothesize that MSC can serve as an immunization vehicle to deliver Bordetella pertussis (Bp) antigens. MSC were isolated from bone marrow. To confirm MSC characteristics, cells were differentiated into chondrocytes, adipocytes and osteocytes. Flow cytometry a

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Krausgrill, Benjamin, Marius Vantler, Volker Burst, et al. "Influence of Cell Treatment with PDGF-BB and Reperfusion on Cardiac Persistence of Mononuclear and Mesenchymal Bone Marrow Cells after Transplantation into Acute Myocardial Infarction in Rats." Cell Transplantation 18, no. 8 (2009): 847–53. http://dx.doi.org/10.3727/096368909x471134.

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Bone marrow cells are used for cell therapy after myocardial infarction (MI) with promising results. However, cardiac persistence of transplanted cells is rather low. Here, we investigated strategies to increase the survival and cardiac persistence of mononuclear (MNC) and mesenchymal (MSC) bone marrow cells transplanted into infarcted rat hearts. MNC and MSC (male Fischer 344 rats) were treated with different doses of PDGF-BB prior to intramyocardial injection into border zone of MI (syngeneic females, permanent LAD ligation) and hearts were harvested after 5 days and 3 weeks. In additional e

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Dewi, Dian Andriani Ratna, and Ferry Sandra. "Conditioned Media of Human Umbilical Cord Blood Mesenchymal Stem Cell Inhibits Ultraviolet B-induced Apoptosis in Fibroblasts." Indonesian Biomedical Journal 11, no. 1 (2019): 85–90. http://dx.doi.org/10.18585/inabj.v11i1.544.

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BACKGROUND: Ultraviolet (UV)B irradiated-skin cells may respond either by activating protective or apoptotic mechanisms. Several treatments has been reported to prevent apoptosis of the skin cell. To date, despite of the cell, secretome of mesenchymal stem cell (MSC) has been progressively explored for various treatment. Current research was conducted to find out the possible effect of MSC's secretome to protect normal cells from the UVB irradiation.METHODS: For preparation of the conditioned media human umbilical cord blood mesenchymal stem cell (CM-hUCB-MSC), hUCB was collected and separated

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Ramos, Teresa L., Luis Ignacio Sánchez-Abarca, Beatriz Rosón, et al. "Extracellular Vesicles Play an Important Role in Intercellular Communication Between Bone Marrow Stroma and Hematopoietic Progenitor Cells in Myeloproliferative Neoplasms." Blood 128, no. 22 (2016): 1957. http://dx.doi.org/10.1182/blood.v128.22.1957.1957.

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Abstract The complex interplay between bone marrow-derived mesenchymal stromal cells (BM-MSC) and neoplastic hematopoietic cells is involved in the progression of myeloproliferative neoplastic (MPN) diseases. Extracellular vesicles (EV) have emerged as a complex cell-to-cell communication system within the neoplastic microenvironment. EV are able to reprogram recipient cells by transferring proteins, mRNA and microRNA from their cell of origin. We aimed to analyze the microRNA content of EV obtained from MPN BM-MSC, as well as the changes induced when these EV are incorporated into hematopoiet

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Ramos, Teresa L., Luis Ignacio Sánchez-Abarca, Rosón Beatriz, et al. "HDAC8 Overexpression in Mesenchymal Stromal Cells from JAK2+ myeloproliferative Neoplasms: A New Therapeutic Target?" Blood 126, no. 23 (2015): 2831. http://dx.doi.org/10.1182/blood.v126.23.2831.2831.

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Abstract JAK2-V617F mutation in hematopoietic stem cells (HSC) is a common finding in myeloproliferative neoplasms (MPNs). Although alterations in the hematopoietic microenvironment have been described in these entities, information on the functional and genetic characteristics of bone marrow (BM) derived mesenchymal stromal cells (BM-MSC) from JAK2+ MPNs patients is scarce. The aim of the current study was to characterize and compare BM-MSC from 24 MPNs patients with JAK2V617F mutation (14 BM-MSC from essential thrombocythemia-ET and 10 BM-MSC from polycythemia vera-PV) with those from 14 hea

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Miner, Samantha, Nancy F. Hensel, Bahey Salem, et al. "A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency." Blood 124, no. 21 (2014): 316. http://dx.doi.org/10.1182/blood.v124.21.316.316.

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Abstract Immunologic tolerance is a critical homeostatic function to protect self from auto-immunity. Various immune-regulatory cells, including regulatory T cell (Treg), myeloid derived suppressor cell (MDSC), tolerogenic dendritic cell, and mesenchymal stromal cell (MSC) are responsible for orchestrating this tolerance. Immune-regulatory cells play a central role in the pathophysiology of cancer immunity, autoimmune disease, and graft versus host disease and can be used in adoptive cell therapy. There is therefore a need for a standardized method to evaluate the suppressive function of these

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Chapel, Alain, Aisha Nasef, Noelle Mathieu, et al. "Human Mesenchymal Stem Cells Express HLA-G: Role in MSC Mediated Immunosuppressive Effect." Blood 108, no. 11 (2006): 4257. http://dx.doi.org/10.1182/blood.v108.11.4257.4257.

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Abstract Mesenchymal stem cells (MSC) possess immunomodulatory properties, being able to suppress allogenic T cell response and modify maturation of antigen presenting cells. Recently its role for the treatment of graft versus host disease has been reported. The mechanisms of immunosuppression induced by MSC are being currently investigated. HLA-G is a non-classical major histocompatibility complex (MHC) class I antigen HLA-G known by its strong immune-inhibtory property. We examined if HLA-G plays a role as a mediator of MSC induced immunosuppression. The expression of HLA-G on human MSC alon

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Chan, Jennifer L., Jonathan S. Harrison, Nicholas M. Ponzio, and Pranela Rameshwar. "Mesenchymal Stem Cells (MSC) Exhibit Antigen Presenting (APC) and Phagocytic Properties: Implicatins to Bnone Marrow Failure during Inflammation." Blood 104, no. 11 (2004): 4249. http://dx.doi.org/10.1182/blood.v104.11.4249.4249.

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Abstract Mesenchymal stem cells (MSC) mostly surround the vasculature system of bone marrow (BM). MSC have been shown to exhibit immune suppressive properties. Since MSC express MHC Class II antigen, the question is whether these cells can act as APC. To this end, we hypothesize that MSC have the ability to present non-self antigens while acting as immune modulators. These dual roles of MSC prevent exacerbated inflammatory responses in the BM, thereby preventing hematopoietic dysfunction. A ‘dampened’ immune response in BM during insults by foreign agents could cause protection of the barrier

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Zhang, Xiaohong, Masako Hirai, Susana Cantero, et al. "Reevaluation of Factors Leading to the Successful Isolation of Mesenchymal Stem Cells From Human Umbilical Cord Blood and Their Differentiation to Mesenchymal Lineages." Blood 114, no. 22 (2009): 3232. http://dx.doi.org/10.1182/blood.v114.22.3232.3232.

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Abstract Abstract 3232 Poster Board III-169 Introduction Cord blood derived mesenchymal stem cells (CB-MSC) have been identified as an alternative cell source to bone marrow derived mesenchymal stem cells (BM-MSC) and adipose tissue derived mesenchymal stem cells (AT-MSC) for use in regenerative medicine. However, the low frequency of these cells in cord blood (CB) has led to conflicting reports of its efficacy and this, in turn, has been the main reason limiting their clinical use thus far. We searched for critical factors determining successful isolation of CB-MSC from more than 300 units of

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Chen, Bin, Jing Yu, Qianqian Wang, et al. "Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc." Stem Cells International 2018 (July 18, 2018): 1–11. http://dx.doi.org/10.1155/2018/9501747.

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The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. However, safety concerns over hBM-MSCs limit their clinical application. In this study, we observed that hBM-MSC-conditioned medium (hBM-MSC-CM) promotes gastric cancer development via upregulation of c-Myc. Our results showed that c-Myc was upregulated in MGC-803 and BGC-823 cells after hBM-MSC-CM treatment. Moreover, we found that the c-Myc inhibitor JQ1 and c-Myc siRNA decreased the expression o

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Holthaus, Michelle, Nivethiha Santhakumar, Thorsten Wahlers, and Adnana Paunel-Görgülü. "The Secretome of Preconditioned Mesenchymal Stem Cells Drives Polarization and Reprogramming of M2a Macrophages toward an IL-10-Producing Phenotype." International Journal of Molecular Sciences 23, no. 8 (2022): 4104. http://dx.doi.org/10.3390/ijms23084104.

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The preconditioning of mesenchymal stem cells (MSCs) has been recognized as an attractive tool to improve their regenerative and immunomodulatory capacities based on their paracrine effects. In this study, we examined the potential of an MSC-conditioned medium (MSC-CM) to alter the phenotype of murine macrophages and to drive reprogramming toward an anti-inflammatory, M2-like state in vitro. We further explored the impact of MSC cytokine preconditioning on the immunosuppressive properties of the MSC secretome. The MSC-CM suppressed the expression of proinflammatory genes in murine M1 macrophag

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Jammes, Manon, Frédéric Cassé, Emilie Velot, et al. "Pro-Inflammatory Cytokine Priming and Purification Method Modulate the Impact of Exosomes Derived from Equine Bone Marrow Mesenchymal Stromal Cells on Equine Articular Chondrocytes." International Journal of Molecular Sciences 24, no. 18 (2023): 14169. http://dx.doi.org/10.3390/ijms241814169.

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Osteoarthritis (OA) is a widespread osteoarticular pathology characterized by progressive hyaline cartilage degradation, exposing horses to impaired well-being, premature career termination, alongside substantial financial losses for horse owners. Among the new therapeutic strategies for OA, using mesenchymal stromal cell (MSC)-derived exosomes (MSC-exos) appears to be a promising option for conveying MSC therapeutic potential, yet avoiding the limitations inherent to cell therapy. Here, we first purified and characterized exosomes from MSCs by membrane affinity capture (MAC) and size-exclusio

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Jezierska-Wozniak, Katarzyna, Emilia Sinderewicz, Wioleta Czelejewska, Pawel Wojtacha, Monika Barczewska, and Wojciech Maksymowicz. "Influence of Bone Marrow-Derived Mesenchymal Stem Cell Therapy on Oxidative Stress Intensity in Minimally Conscious State Patients." Journal of Clinical Medicine 9, no. 3 (2020): 683. http://dx.doi.org/10.3390/jcm9030683.

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Neurological disorders, including minimally conscious state (MCS), may be associated with the presence of high concentrations of reactive oxygen species within the central nervous system. Regarding the documented role of mesenchymal stem cells (MSCs) in oxidative stress neutralization, the aim of this study is to evaluate the effect of bone marrow-derived MSC (BM-MSC) transplantation on selected markers of oxidative stress in MCS patients. Antioxidant capacity was measured in cerebrospinal fluid (CSF) and plasma collected from nine patients aged between 19 and 45 years, remaining in MCS for 3

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Krampera, Mauro, Cedric Mènard, Luciano Pacelli, et al. "Quality Controls of Immune Regulatory Properties of Ex-Vivo, GMP-Grade Expanded Mesenchymal Stromal Cells for Clinical Use (European multicenter study CASCADE),." Blood 118, no. 21 (2011): 4049. http://dx.doi.org/10.1182/blood.v118.21.4049.4049.

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Abstract Abstract 4049 Aim of the European Consortium CASCADE is to standardize GMP-grade production and clinical use of Mesenchymal Stromal Cells (MSC) to treat skin and corneal wounds. MSC possess immunogenicity and immunomodulatory properties that must be carefully addressed before clinical use. CASCADE Immunological Unit is aimed to set up and validate a wide panel of functional assays to fully characterize in a standardized and reproducible manner the immunomodulatory properties of MSC obtained inside CASCADE Units from bone marrow, adipose tissue, cord blood, and amniotic membrane (BM, A

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Kudinov, Vasily A., Rafael I. Artyushev, Irina M. Zurina, et al. "Antimicrobial and Regenerative Effects of Placental Multipotent Mesenchymal Stromal Cell Secretome-Based Chitosan Gel on Infected Burns in Rats." Pharmaceuticals 14, no. 12 (2021): 1263. http://dx.doi.org/10.3390/ph14121263.

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Background: There is a need for better strategies to promote burn wound healing and prevent infection. The aim of our study was to develop an easy-to-use placental multipotent mesenchymal stromal cell (MMSC) secretome-based chitosan hydrogel (MSC-Ch-gel) and estimate its antimicrobial and regenerative activity in Staphylococcus aureus-infected burn wounds in rats. Methods: Proteomic studies of the MMSC secretome revealed proteins involved in regeneration, angiogenesis, and defence responses. The MMSC secretome was collected from cultured cells and mixed with water-soluble chitosan to prepare t

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Lebedeva, I. Yu, O. Mityashova, and E. Montvila. "Metabolic indicators in hens of different ages and at different reproductive states." Genetics and breeding of animals, no. 4 (February 25, 2025): 5–13. https://doi.org/10.31043/2410-2733-2024-4-5-13.

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The decline in the reproductive potential of hens by the end of the first productive period is closely related to the biological process of ovarian aging. At the same time, the functioning of the reproductive system is de termined by the intensity and direction of metabolic processes in the body of females.Objective: The aim of the presented work was to study the relationship between biochemical markers of metabolic status and the manifestation of age-related decline in egg production in domestic hens.Materials and methods. We performed a comparative study of blood biochemical indicators in yo

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Podestà, Marina, Daniela Cilloni, Elena Ponomareva, et al. "Dissecting the Hematopoietic Niche to Improve Transplant: Hedgehog and Wnt Pathways Activation in Fetal Mesenchymal Cells (MSC) Are Associated with Better Support to Hematopoietic Progenitors and Higher Proliferative Capacity Compared to Adult MSC." Blood 118, no. 21 (2011): 4809. http://dx.doi.org/10.1182/blood.v118.21.4809.4809.

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Abstract Abstract 4809 Background. Mesenchymal Stem Cells (MSC) are among major players of the hematopoietic niche. In addition, they have shown to be useful in clinical studies both as immune-modulators as well as in regenerative medicine. However, a major obstacle for proving their usefulness is to obtain a clinically effective cell dose, since often less than 10̂6 /kg of adult MSC have been used. Thus, their potential efficacy can be either disregarded or not formally proved. In addition, forcing in vitro the proliferative potential of adult BM derived MSC (BM-MSC) implies the risk of gener

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Tormin, Ariane, Jan Claas Brune, Stuart Walsh, Johan Richter, Xiaolong Fan, and Stefan Scheding. "Human Primary Mensenchymal Stromal Progenitor Cells Are Highly Enriched in Both, the CD271+/CD146+ and CD271+/CD146− Bone Marrow Population with the Latter Acquiring CD146 Expression upon Culture in-Vitro." Blood 112, no. 11 (2008): 2422. http://dx.doi.org/10.1182/blood.v112.11.2422.2422.

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Abstract Culture-derived mesenchymal stromal cells (MSC), which are attractive candidates for clinical cell therapy approaches, arise from primary MSC progenitor/stem cells in the bone marrow. Recently, several groups have reported markers (CD271, CD146, GD2, SSEA4, etc.) that allowed for an enrichment of CFU-F, i.e. primary MSC progenitors. However, the exact phenotype of the bona fide mesenchymal stem/progenitor cells has not yet not been sufficiently defined. We therefore aimed to investigate primary MSC in bone marrow subpopulations defined by the expression of CD271 and CD146, as both mar

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Soland, Melisa, Evan J. Colletti, Mariana Bego, et al. "Modulation of Mesenchymal Stem Cell MHC-I Complex Increases Engraftment In Vivo." Blood 116, no. 21 (2010): 1457. http://dx.doi.org/10.1182/blood.v116.21.1457.1457.

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Abstract Abstract 1457 Mesenchymal stem cells (MSC) are good candidates for cell therapies due to their immunomodulatory properties, ability to home to/engraft damaged tissues, and potential to differentiate into different cell types. However, when transplanted (Tx) in an allogeneic setting, MSC can elicit an immune response, activating the recipient's cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells, resulting in rejection of the Tx cells and reduced therapeutic efficacy. Human cytomegalovirus (HCMV, has developed several strategies to evade CTL and NK cell recognition. HCMV avoids

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Xie, Baocheng, Shichun Chen, Yongxiang Xu, et al. "Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Stem Cells International 2021 (September 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/9149315.

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Degenerative disc disease (DDD) can cause severe low back pain, which will have a serious negative impact on the ability to perform daily tasks or activities. For the past few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy for the treatment of DDD. However, the clinical efficacy of MSC in the treatment of DDD still lacks clinical evidence and is controversial. We conducted a meta-analysis with randomized controlled trials (RCTs) to evaluate the clinical efficacy and safety of MSC transplantation in patients with DDD. We searched major databases using ter

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Mohana Kumar, B., G. H. Maeng, Y. M. Lee, et al. "212 PORCINE BONE MARROW-DERIVED MESENCHYMAL STEM CELLS DIFFERENTIATE IN VITRO INTO SMOOTH MUSCLE CELLS." Reproduction, Fertility and Development 24, no. 1 (2012): 218. http://dx.doi.org/10.1071/rdv24n1ab212.

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In the context of multipotent stem cells, mesenchymal stem cells (MSC) derived from bone marrow have been identified as most promising cell types for the treatment of smooth muscle related injured tissues and organs. In the present study, the ability of porcine bone marrow derived MSC to differentiate in vitro into smooth muscle cells (SMC) was examined. MSC were isolated from domestic pig bone marrow by their readily adherent property to tissue culture plastic with fibroblast-like morphology. Cells were analysed for the expression of MSC specific markers by flow cytometer and mesenchymal line

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Putignano, Pietro, Paola Toja, Antonella Dubini, Francesca Pecori Giraldi, Salvatore Maria Corsello, and Francesco Cavagnini. "Midnight Salivary Cortisol Versus Urinary Free and Midnight Serum Cortisol as Screening Tests for Cushing’s Syndrome." Journal of Clinical Endocrinology & Metabolism 88, no. 9 (2003): 4153–57. http://dx.doi.org/10.1210/jc.2003-030312.

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The diagnosis of Cushing’s syndrome (CS) is often a challenge. Recently, the determination of late night salivary cortisol levels has been reported to be a sensitive and convenient screening test for CS. However, no studies have included a comparison with other screening tests in a setting more closely resembling clinical practice, i.e. few patients with CS to be distinguished from patients with pseudo-Cushing states (PC), including the large population of obese patients. The aim of this study was to compare the diagnostic performance of midnight salivary cortisol (MSC) measurement with that o

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Fitzpatrick, Emilie, Mary DeHart, Juan Tercero, Tommy Brown, and Shashikumar Salgar. "Bone marrow derived mesenchymal stem cell therapy to improve nerve regeneration and function in a rat limb transplant model (P2170)." Journal of Immunology 190, no. 1_Supplement (2013): 69.23. http://dx.doi.org/10.4049/jimmunol.190.supp.69.23.

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Abstract Introduction: Preventing immune rejection and optimizing nerve regeneration are keys to successful outcomes in hand and limb transplantation (Tx). Our objective was to investigate whether MSC can improve nerve regeneration and function. Methods: Orthotopic syngeneic right hind-limb transplants were performed in Lewis (RT1.Al) rats. Limb recipient rats received syngeneic MSC (5 x106; passage ≤7) or vehicle (saline) locally around nerve, bone and vascular anastamoses sites, and 5x106 MSC intravenously. Results: Rat MSC expanded ex vivo were CD29+, CD90+, CD34-, CD31-, CD45low, MHC Class

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Bocelli-Tyndall, Chiara, Emanuele Trella, Audrey Frachet та ін. "FGF2 induces RANKL gene expression as well as IL1β regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells". Annals of the Rheumatic Diseases 74, № 1 (2013): 260–66. http://dx.doi.org/10.1136/annrheumdis-2013-204235.

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ObjectiveHuman bone marrow mesenchymal stromal cells (hBM-MSC) are being applied in tissue regeneration and treatment of autoimmune diseases (AD). Their cellular and immunophenotype depend on isolation and culture conditions which may influence their therapeutic application and reflect their in vivo biological functions. We have further characterised the phenotype induced by fibroblast growth factor 2 (FGF2) on healthy donor hBM-MSC focusing on the osteoimmunological markers osteoprotegerin (OPG), receptor activator of nuclear factor kB (RANK), RANK ligand (RANKL) and HLA-DR and their regulati

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Saccardi, Riccardo, Serena Urbani, Benedetta Mazzanti, et al. "Human Bone Marrow MSC Transformation in Different Culture Conditions." Blood 108, no. 11 (2006): 4253. http://dx.doi.org/10.1182/blood.v108.11.4253.4253.

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Abstract Human mesenchymal stem cells (MSC) have been isolated from different sources, expanded and characterized extensively. Their plasticity and immunomodulatory properties made these cells extremely promising in the fields of immunotherapy and regenerative medicine. Both safety and modality of preparation in a clinical setting are still be defined. We generated human MSC from normal donors bone marrow cells following 2 different isolation methods and culture conditions: white blood cells (buffy-coat) were plated in IMDM with gentamycin, 10% FBS and 2% Ultroser® G. Half of the complete medi

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Nicodemou, Andreas, Soňa Bernátová, Michaela Čeháková, and Ľuboš Danišovič. "Emerging Roles of Mesenchymal Stem/Stromal-Cell-Derived Extracellular Vesicles in Cancer Therapy." Pharmaceutics 15, no. 5 (2023): 1453. http://dx.doi.org/10.3390/pharmaceutics15051453.

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Despite the tremendous efforts of many researchers and clinicians, cancer remains the second leading cause of mortality worldwide. Mesenchymal stem/stromal cells (MSCs) are multipotent cells residing in numerous human tissues and presenting unique biological properties, such as low immunogenicity, powerful immunomodulatory and immunosuppressive capabilities, and, in particular, homing abilities. Therapeutic functions of MSCs are mediated mostly by the paracrine effect of released functional molecules and other variable components, and among them the MSC-derived extracellular vesicles (MSC-EVs)

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Josefsen, Dag, Axel Kuchler, Mengyu Wang, Guttorm Haraldsen, and Gunnar Kvalheim. "Human Bone Marrow Mononuclear Cells, CD34+ Cells and CD133+ Cells Do Not Form Vascular Structures in Vivo." Blood 112, no. 11 (2008): 5453. http://dx.doi.org/10.1182/blood.v112.11.5453.5453.

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Abstract The clinical results of using bone marrow-derived progenitor cells to repair ischemic tissue in coronary disease are controversial since some studies demonstrate improvement of cardiac function, whereas others do not. In these studies both unmanipulated mononuclear bone marrow cells (MNC) and highly enriched stem cells such as CD34+, CD133+ or mesenchymal cells (MSC) were used. In this study we have examined the in vitro and in vivo endothelial progenitor properties of these populations. MNC were obtained from whole BM. CD34+ cells and CD133+ cells were isolated using magnetic bead te

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Monsanto, Megan M., Bingyan J. Wang, and Mark A. Sussman. "Synthetic MSC?" Circulation Research 120, no. 11 (2017): 1694–95. http://dx.doi.org/10.1161/circresaha.117.310986.

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Kordium, V. A., and D. M. Irodov. "About MSC." Biopolymers and Cell 38, no. 2 (2022): 117–42. http://dx.doi.org/10.7124/bc.000a78.

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Graubmann, Peter. "Describing interactions between MSC components: the MSC connectors." Computer Networks 42, no. 3 (2003): 323–42. http://dx.doi.org/10.1016/s1389-1286(03)00246-9.

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Zinöcker, Severin, Mengyu Wang, Janne Nestvold, John Torgils Vaage, Gunnar Kvalheim, and Bent Rolstad. "Mesenchymal Stem Cell Therapy in a Rat Model for GvHD." Blood 112, no. 11 (2008): 4620. http://dx.doi.org/10.1182/blood.v112.11.4620.4620.

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Abstract Graft-vs-host-disease (GvHD) is an important hindrance for the usage of allogeneic bone marrow cell transplantation (alloBMT) as a treatment strategy for leukemias and other hematopoietic malignancies. Mesenchymal stem cells (MSC) can interact with the immune system and inhibit alloreactive cells. Infusions of MSC into GvHD patients have alleviated disease severity and overall survival and in recent clinical trials. We are studying the immunoregulatory potential of MSC as a putative therapy for GvHD in an experimental animal model. Bone marrow-derived MSC from PVG rats are highly effi

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François, Moïra, Raphaëlle Romieu-Mourez, Sophie Stock-Martineau, and Jacques Galipeau. "IFN-g-Stimulated Mesenchymal Stromal Cells Acquire the Ability To Cross-Present Exogenous Soluble Antigens and Lead to an Effective Immune Response." Blood 110, no. 11 (2007): 4898. http://dx.doi.org/10.1182/blood.v110.11.4898.4898.

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Abstract Antigen cross-presentation is the mechanism by which exogenous antigens can be presented by major histocompatibility complex (MHC) class I molecules to CD8+ T cells. This process is efficiently performed by professional antigen presenting cells (APC) such as dendritic cells and macrophages. Recently, we and others have shown that IFN-g enables the upregulation of the expression of MHC class I & II molecules by marrow-derived Mesenchymal Stromal Cells (MSCs) and that MHC II-mediated antigen presentation can lead to cell-mediated protective immunity to xenoantigens [Stagg et al., Bl

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Tondreau, Tatiana, Nathalie Meuleman, Marielle Dejeneffe, Alain Delforge, Dominique Bron, and Laurence Lagneaux. "CD133 Positive Mesenchymal Stem Cells in Mobilized Peripheral Blood and Cord Blood: Proliferation, Oct4 Expression and Plasticity." Blood 104, no. 11 (2004): 4256. http://dx.doi.org/10.1182/blood.v104.11.4256.4256.

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Abstract Background: Mesenchymal Stem Cells (MSC) can be isolated from bone marrow, adipose and fetal tissues, but their presence in Mobilized Peripheral Blood (MPB) and in Umbilical Cord Blood (UCB) remains controversial. Methods: In this study we evaluated whether MPB (n=6) and UCB (n=8) could be two other sources of MSC beside Bone Marrow (BM). CD133 positive cell fraction was isolated through immunomagnetic system and MNC were seeded in medium supplemented or not with 5% of conditioned medium durong the first 48 hours of adhesion. MSC derived from MPB or UCB were identified by their expres

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