Academic literature on the topic 'MsDps2-DNA'

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Journal articles on the topic "MsDps2-DNA"

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Saraswathi, Ramachandran, Rakhi Pait Chowdhury, Sunanda Margrett Williams, Payel Ghatak та Dipankar Chatterji. "The Mycobacterial MsDps2 Protein Is a Nucleoid-Forming DNA Binding Protein Regulated by Sigma Factors σA and σB". PLoS ONE 4, № 11 (2009): e8017. http://dx.doi.org/10.1371/journal.pone.0008017.

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Dissertations / Theses on the topic "MsDps2-DNA"

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Priyanka. "Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM." Thesis, 2023. https://etd.iisc.ac.in/handle/2005/6133.

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Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), and hybrid PKs/NRPs. The final products from these three classes display different characteristics like antibiotics, antiparasitic agents, antifungals, anticancer drugs, and immunosuppressants. As these products have wide range of potential application in pharmaceuticals, a number of biochemical studies have been carried out to elucidate of their biosynthetic pathways. The bio
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2

Garg, Priyanka. "Structural and functional insights into hybrid AT-less megaenzyme synthase (NRPS) and DNA-MsDps2 complexes using single particle cryo-EM." Thesis, 2023. https://etd.iisc.ac.in/handle/2005/6118.

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Abstract:
Microorganisms, mainly bacteria and fungi, are the producers of structurally diverse, complex organic compounds called as secondary metabolites. These metabolites include polyketides (PKs), non-ribosomal peptides (NRPs), and hybrid PKs/NRPs. The final products from these three classes display different characteristics like antibiotics, antiparasitic agents, antifungals, anticancer drugs, and immunosuppressants. As these products have wide range of potential application in pharmaceuticals, a number of biochemical studies have been carried out to elucidate of their biosynthetic pathways. The bio
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3

Roy, Siddhartha. "Structural Studies On Mycobacterium Smegmatis Dps Molecules." Thesis, 2007. https://etd.iisc.ac.in/handle/2005/642.

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Oxidative stress is a universal phenomenon experienced by both aerobic and anaerobic organisms. Reactive oxygen species (ROS) are generated during the stress, which can damage most cellular components including proteins, lipids and DNA. Naturally, organisms have evolved defence mechanisms to prevent oxidative damage. In prokaryotic systems, Dps (DNA binding protein from stationary phase cells) forms an important component of the mechanisms. Dps is known to be produced maximally during the stationary phase of bacterial growth. They exhibit ferroxidase activity as well. Dps homologs have been id
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4

Roy, Siddhartha. "Structural Studies On Mycobacterium Smegmatis Dps Molecules." Thesis, 2007. http://hdl.handle.net/2005/642.

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Abstract:
Oxidative stress is a universal phenomenon experienced by both aerobic and anaerobic organisms. Reactive oxygen species (ROS) are generated during the stress, which can damage most cellular components including proteins, lipids and DNA. Naturally, organisms have evolved defence mechanisms to prevent oxidative damage. In prokaryotic systems, Dps (DNA binding protein from stationary phase cells) forms an important component of the mechanisms. Dps is known to be produced maximally during the stationary phase of bacterial growth. They exhibit ferroxidase activity as well. Dps homologs have been id
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5

Williams, Sunanda Margrett. "The Dynamics of Iron in Miniferritins : A Structure-Function Connection." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/2788.

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The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA from the harmful effects of reactive oxygen species by DNA compaction. The work compiled in this thesis has been an effort to study oligomerization and dynamics of iron metabolism by these nano-protein compartments. Chapter 1 gives a general introduction on stress, especially oxidative stress, and the ways bacteria fight back the host resistance systems. This has been elabora
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6

Williams, Sunanda Margrett. "The Dynamics of Iron in Miniferritins : A Structure-Function Connection." Thesis, 2014. http://etd.iisc.ernet.in/handle/2005/2788.

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Abstract:
The DNA binding proteins under starvation (Dps) from M. smegmatis are cage-like structures which internalize iron and bind DNA. They provide resistance to the cells from free radical damage, and physically protect the DNA from the harmful effects of reactive oxygen species by DNA compaction. The work compiled in this thesis has been an effort to study oligomerization and dynamics of iron metabolism by these nano-protein compartments. Chapter 1 gives a general introduction on stress, especially oxidative stress, and the ways bacteria fight back the host resistance systems. This has been elabora
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7

Saraswathi, Ramachandran. "Starvation Response In Mycobacterium Smegmatis : A Tale Of Two Proteins." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/918.

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The Dps (DNA-Binding Protein from Starved Cells) proteins are a class of stress-specific proteins with a major role in protecting DNA during the stationary phase of bacterial growth, through direct physical binding as well as ferroxidation. These proteins are characteristically dodecameric in nature. Mycobacterium smegmatis, which is the model organism used in this study has two Dps homologues- MsDps1 and MsDps2. MsDps1, that has previously been studied, is exceptional in having trimeric as well as dodecameric states in vitro. This work focuses on the functional domains of MsDps1, with resp
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8

Saraswathi, Ramachandran. "Starvation Response In Mycobacterium Smegmatis : A Tale Of Two Proteins." Thesis, 2009. http://hdl.handle.net/2005/918.

Full text
Abstract:
The Dps (DNA-Binding Protein from Starved Cells) proteins are a class of stress-specific proteins with a major role in protecting DNA during the stationary phase of bacterial growth, through direct physical binding as well as ferroxidation. These proteins are characteristically dodecameric in nature. Mycobacterium smegmatis, which is the model organism used in this study has two Dps homologues- MsDps1 and MsDps2. MsDps1, that has previously been studied, is exceptional in having trimeric as well as dodecameric states in vitro. This work focuses on the functional domains of MsDps1, with resp
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9

Chowdhury, Rakhi Pait. "Newer Insights On Structure, Function And Regulation Of Dps Protein From Mycobacterium smegmatis." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/970.

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The first chapter will provide an introduction to the physiology, pathogenesis and biology of mycobacteria. Host-pathogen interactions, different modes of resistance of the bacteria, adaptations for survival under nutrient and oxygen depleted conditions has been discussed. This is followed by a general discussion on gene expression and regulation in the microbe. The physiology of bacteria under stresses from the view of the transcriptional regulation of specific genes has also been discussed. The scope and objective of the present study in M. smegmatis covered in the thesis has been considered
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10

Chowdhury, Rakhi Pait. "Newer Insights On Structure, Function And Regulation Of Dps Protein From Mycobacterium smegmatis." Thesis, 2009. http://hdl.handle.net/2005/970.

Full text
Abstract:
The first chapter will provide an introduction to the physiology, pathogenesis and biology of mycobacteria. Host-pathogen interactions, different modes of resistance of the bacteria, adaptations for survival under nutrient and oxygen depleted conditions has been discussed. This is followed by a general discussion on gene expression and regulation in the microbe. The physiology of bacteria under stresses from the view of the transcriptional regulation of specific genes has also been discussed. The scope and objective of the present study in M. smegmatis covered in the thesis has been considered
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