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Jung-Romeo, Sabrina. "Caractérisation de MSI2 et MSI3 : deux sous-unités du CRL4 et potentiels régulateurs chromatiniens chez Arabidopsis thaliana." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ020/document.
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La dégradation sélective des protéines par un mécanisme ubiquitine et protéasome 26S dépendant est conservée chez tous les eucaryotes. Les E3 ubiquitine ligases sont les derniers acteurs de la cascade d’ubiquitinylation et sont responsables de la sélection spécifique des protéines cibles pour leur dégradation. Les enzymes E3 de type CRL4 forment des complexes multiprotéiques dont les récepteurs de substrats sont appelés DCAF pour DDB1-CUL4 Associated Factor. Les études réalisées chez les mammifères et les levures ont permis d’identifier une signature spécifique des DCAF : le motif WDxR à la fin d’un domaine WD40. L’analyse bioinformatique a montré l’existence de plus de 85 DCAF potentielles chez Arabidopsis thaliana. Parmi ces récepteurs, nous nous sommes intéressés à une famille multigénique appelée MSI (Multicopy Suppressor of IRA1). Des études précédentes ont permis de montrer que MSI1 et MSI4 participaient chacune à un complexe CRL4 différent capable d’interagir fonctionnellement avec un complexe PRC2 (Polycomb Repressive Complex 2) pour moduler une régulation épigénétique.Les résultats obtenus et décrits dans ce manuscrit mettent en évidence une interaction physique entre les protéines MSI (2 ou 3) et DDB1a suggérant l’existence d’un complexe multimérique incluant CUL4. L’interrogation des données publiques confrontées à nos données expérimentales, nous a permis d’établir que l’expression des deux gènes était régulée de manière cycle cellulaire dépendante. De plus, un mutant perte de fonction msi3 présente un phénotype de retard de croissance suggérant une fonction de contrôle du cycle cellulaire. D’autre part, leur capacité d’interagir avec des régulateurs chromatiniens permet d’envisager une régulation par voie épigénétique. Toutefois, le rôle exact de ces protéines reste à déterminer<br>Selective protein degradation by the UPS (Ubiquitin Proteasome System) is highly conserved in all eukaryotes. The E3 ubiquitin ligases are the last actors in the ubiquitylation pathway and target specifically the proteins for degradation. CRL4 E3 ligases form multiprotein complexes where the substrate receptors are called DCAFs for DDB1-CUL4 Associated Factor. Studies made in mammals and yeast allowed to highlight a characteristic signature for the DCAFs: the WDxR motif at the end of a WD40 domain. Bioinformatic studies could identify around 85 potential DCAFs in Arabidopsis thaliana. Among those receptors, we were interested in a small multigenic family called MSIs (Multicopy Suppressor of IRA1). Previous studies showed that MSI1 and MSI4 belong to different CRL4 complexes functionally connected to a PRC2 complex (Polycomb Repressive Complex 2). The results obtained and described in this manuscript highlight a physical interaction between MSI (2 or 3) and DDB1a suggesting the existence of a multimeric complex including CUL4. Furthermore, bioinformatic as well as experimental data, allowed us to establish that MSI2 and MSI3 gene expression are cell cycle regulated. Moreover, phenotypic analysis of an msi3 loss of function mutant showed a delayed growth implying a function as cell cycle regulator. On the other hand, the ability of MSI3 to interact with chromatin regulators points to an epigenetic regulatory pathway. However, the exact function of these proteins remains to be determined
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Comaga, Kerim. "MSc Architecture." Thesis, KTH, Arkitektur, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298483.
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This project has revolved around how to expand Stockholm in socially sustainable way. As is the case with many other cities in the world, inspired by modernist ideals, expansion during the 1900: s have shaped Stockholm into an archipelago of islands with mostly homogenous housing types that exist within an urban structure of centre and periphery. The Stockholm City Council is trying counter this situation by expanding the city centre into eight new regional cores by densifying a few chosen areas. This is done by conforming to old traditions of placing existing housing types and public spaces in a similar way as before. How do you go one step further in decentralizing Stockholm and breaking away from these traditions? The idea for this project is then to create an alternative typology that will be spread out homogeneously throughout the regional cores and that will grow organically as new needs emerge over time. The typology itself is simply a building scaffolding, a 6x6x7 steel grid, that will act as a tool for urban planning and host creation and expansion of new housing and public situations that together aim to constitute new parts of an alternative type of growing city centre.
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Weber, Sérgio. "ASPE/MSC." Florianópolis, SC, 2005. http://repositorio.ufsc.br/handle/123456789/102368.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação<br>Made available in DSpace on 2013-07-16T00:46:12Z (GMT). No. of bitstreams: 1
224905.pdf: 5536445 bytes, checksum: 9c37dced0f425adf455a3f6d0fa8b466 (MD5)<br>Segundo dados do ministério da ciência e tecnologia (MCT), o mercado brasileiro na área de software é composto predominantemente por micro e pequenas empresas (MPEs), cujos processos são executados geralmente de modo informal, improvisado e com pouca visibilidade. Esse cenário gera uma série de dificuldades a essas organizações, tornando-as enfraquecidas para competir no mercado e crescerem. Uma alternativa para a mudança desse quadro é o investimento em estabelecimento de processos sistemáticos de software, já que a qualidade dos produtos desenvolvidos são altamente influenciados pelos seus processos de produção.
Nesse contexto, o presente trabalho propõe e avalia a abordagem ASPE/MSC (Approach for Software Process Establishment in Micro and Small Companies), cujo objetivo é estabelecer processos de software em MPEs, considerando suas características e limitações. Seu desenvolvimento está baseado em estudos sobre estabelecimento de processos de software, na adaptação de técnicas e abordagens existentes nessa área de pesquisa e na experiência em modelagem de processos de software, obtida pelo LQPS - Laboratório de Qualidade e Produtividade de Software da UNIVALI e pelo Grupo de Qualidade de Software do centro GeNESS. A avaliação da abordagem é realizada por meio de dois estudos de caso, executados em duas pequenas empresas de software em Florianópolis/SC.
Os principais resultados do trabalho são a abordagem ASPE/MSC e as experiências obtidas com a execução dos estudos de caso, que incluem dados qualitativos e quantitativos. A abordagem ASPE/MSC está documentada na forma de um guia, que descreve detalhadamente as atividades que a compõem, os papéis envolvidos na execução das respectivas atividades, templates de documentos para auxiliar na sua aplicação e diretrizes para sua execução num contexto real.
A perspectiva do trabalho é auxiliar micro e pequenas empresas de software a se fortalecerem no mercado, através da melhoria contínua dos seus processos. Com isso, espera-se que, MPEs possam alcançar gradativamente patamares mais elevados de qualidade, produtividade e competitividade.
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Vidal, Puig Santiago. "FAULT DIAGNOSIS TOOLS IN MULTIVARIATE STATISTICAL PROCESS AND QUALITY CONTROL." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/61292.
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[EN] An accurate fault diagnosis of both, faults sensors and real process faults have become more and more important for process monitoring (minimize downtime, increase safety of plant operation and reduce the manufacturing cost). Quick and correct fault diagnosis is required in order to put back on track our processes or products before safety or quality can be compromised. In the study and comparison of the fault diagnosis methodologies, this thesis distinguishes between two different scenarios, methods for multivariate statistical quality control (MSQC) and methods for latent-based multivariate statistical process control: (Lb-MSPC). In the first part of the thesis the state of the art on fault diagnosis and identification (FDI) is introduced. The second part of the thesis is devoted to the fault diagnosis in multivariate statistical quality control (MSQC). The rationale of the most extended methods for fault diagnosis in supervised scenarios, the requirements for their implementation, their strong points and their drawbacks and relationships are discussed. The performance of the methods is compared using different performance indices in two different process data sets and simulations. New variants and methods to improve the diagnosis performance in MSQC are also proposed. The third part of the thesis is devoted to the fault diagnosis in latent-based multivariate statistical process control (Lb-MSPC). The rationale of the most extended methods for fault diagnosis in supervised Lb-MSPC is described and one of our proposals, the Fingerprints contribution plots (FCP) is introduced. Finally the thesis presents and compare the performance results of these diagnosis methods in Lb-MSPC. The diagnosis results in two process data sets are compared using a new strategy based in the use of the overall sensitivity and specificity<br>[ES] La realización de un diagnóstico preciso de los fallos, tanto si se trata de fallos de sensores como si se trata de fallos de procesos, ha llegado a ser algo de vital importancia en la monitorización de procesos (reduce las paradas de planta, incrementa la seguridad de la operación en planta y reduce los costes de producción). Se requieren diagnósticos rápidos y correctos si se quiere poder recuperar los procesos o productos antes de que la seguridad o la calidad de los mismos se pueda ver comprometida. En el estudio de las diferentes metodologías para el diagnóstico de fallos esta tesis distingue dos escenarios diferentes, métodos para el control de estadístico multivariante de la calidad (MSQC) y métodos para el control estadístico de procesos basados en el uso de variables latentes (Lb-MSPC). En la primera parte de esta tesis se introduce el estado del arte sobre el diagnóstico e identificación de fallos (FDI). La segunda parte de la tesis está centrada en el estudio del diagnóstico de fallos en control estadístico multivariante de la calidad. Se describen los fundamentos de los métodos más extendidos para el diagnóstico en escenarios supervisados, sus requerimientos para su implementación sus puntos fuertes y débiles y sus posibles relaciones. Los resultados de diagnóstico de los métodos es comparado usando diferentes índices sobre los datos procedentes de dos procesos reales y de diferentes simulaciones. En la tesis se proponen nuevas variantes que tratan de mejorar los resultados obtenidos en MSQC. La tercera parte de la tesis está dedicada al diagnóstico de fallos en control estadístico multivariante de procesos basados en el uso de modelos de variables latentes (Lb-MSPC). Se describe los fundamentos de los métodos mas extendidos en el diagnóstico de fallos en Lb-MSPC supervisado y se introduce una de nuestras propuestas, el fingerprint contribution plot (FCP). Finalmente la tesis presenta y compara los resultados de diagnóstico de los métodos propuestos en Lb-MSPC. Los resultados son comparados sobre los datos de dos procesos usando una nueva estrategia basada en el uso de la sensitividad y especificidad promedia.<br>[CAT] La realització d'un diagnòstic precís de les fallades, tant si es tracta de fallades de sensors com si es tracta de fallades de processos, ha arribat a ser de vital importància en la monitorització de processos (reduïx les parades de planta, incrementa la seguretat de l'operació en planta i reduïx els costos de producció) . Es requerixen diagnòstics ràpids i correctes si es vol poder recuperar els processos o productes abans de que la seguretat o la qualitat dels mateixos es puga veure compromesa. En l'estudi de les diferents metodologies per al diagnòstic de fallades esta tesi distingix dos escenaris diferents, mètodes per al control estadístic multivariant de la qualitat (MSQC) i l mètodes per al control estadístic de processos basats en l'ús de variables latents (Lb-MSPC). En la primera part d'esta tesi s'introduïx l'estat de l'art sobre el diagnòstic i identificació de fallades (FDI). La segona part de la tesi està centrada en l'estudi del diagnòstic de fallades en control estadístic multivariant de la qualitat. Es descriuen els fonaments dels mètodes més estesos per al diagnòstic en escenaris supervisats, els seus requeriments per a la seua implementació els seus punts forts i febles i les seues possibles relacions. Els resultats de diagnòstic dels mètodes és comparat utilitzant diferents índexs sobre les dades procedents de dos processos reals i de diferents simulacions. En la tesi es proposen noves variants que tracten de millorar els resultats obtinguts en MSQC. La tercera part de la tesi està dedicada al diagnòstic de fallades en control estadístic multivariant de processos basat en l'ús de models de variables latents (Lb-MSPC). Es descriu els fonaments dels mètodes més estesos en el diagnòstic de fallades en MSPC supervisat i s'introdueix una nova proposta, el fingerprint contribution plot (FCP). Finalment la tesi presenta i compara els resultats de diagnòstic dels mètodes proposats en MSPC. Els resultats són comparats sobre les dades de dos processos utilitzant una nova estratègia basada en l'ús de la sensibilitat i especificitat mitjana.<br>Vidal Puig, S. (2016). FAULT DIAGNOSIS TOOLS IN MULTIVARIATE STATISTICAL PROCESS AND QUALITY CONTROL [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/61292<br>TESIS
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Mack, Valérie. "Etude des chambres gazeuses à micropistes (MSGC)." Phd thesis, Université de Haute Alsace - Mulhouse, 1997. http://tel.archives-ouvertes.fr/tel-00389593.
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Pieskä, J. (Jukka). "Risk factor based investing:case: MSCI risk factor indices." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201601141032.
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The aim of this thesis is to study risk factor based investing and test how well MSCI constructs their risk factor based indices. Risk factor based investing has gained a lot of media exposure in the recent years and “Smart Beta” products are becoming more popular. Blackrock estimated that there are more than 700 exchange traded products available and they have over $ 529 billion in assets under management. Risk factor investing aims to harvest the risk premia associated with factors like size, momentum and value.
I tested whether MSCI is able to provide higher Sharpe ratios for higher risk exposure indices and how much they deviated from the parent index of MSCI World. I used the Ledoit & Wolf bootstrap inference test to find out whether the Sharpe ratios of high exposure and high capacity indices differ from each other. Furthermore, I tested how well the Fama & French Three Factor-model with the addition of Carhart momentum factor could explain the returns of MSCI’s risk factor indices. I also constructed different risk factor portfolios using risk-parity methods to see whether it is possible to enhance the returns of risk factor indices by combining them.
The main results and conclusions of this thesis were that risk factor investing can provide excess returns. These excess returns are readily available by investing in MSCI’s risk factor indices. Another key finding was that by utilizing risk-parity methods an investor can achieve excess returns over an equally weighted risk factor portfolio and over the MSCI’s own Diversified Mix index. Furthermore, even though MSCI is the world leader in index creation, their way of creating indices doesn’t seem to be very efficient and it would be beneficial to analyse other index providers, too.
The data used in this thesis were gathered from “MSCI’s end of day index data search”. The data consists of six risk factor indices from developed countries. The price data ranged from November 1998 to August 2015. For the Ledoit & Wolf test I gathered four high capacity indices and four high exposure indices from the same time period. The proxies for academic factors were provided by Kenneth French on his website.
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Andrés, Aguayo Luisa de. "The Role of Msi2 in adult and embryonic hematopoiesis." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/586094.
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The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the continued production of blood cells will enable new techniques to expand them for life-saving transplantation therapies. We have used a retroviral integration screen to search for novel genes that regulate hematopoietic stem cell (HSC) function. One of the genes found was Musashi 2 (Msi2), an RNA binding protein that can act as a translational inhibitor. A gene trap mouse model that inactivates the gene shows that Msi2 is more highly expressed in long term (LT) and short term (ST) HSCs as well as in lymphoid myeloid primed progenitors (LMPPs), but much less in intermediate progenitors and mature cells. Mice lacking Msi2 are fully viable up to more than a year but exhibit severe defects in primitive precursors. Cell cycle and gene expression analyses suggest that the main hematopoietic defect in Msi2 defective mice consists in a decreased proliferation capacity of ST-HSCs and LMPPs. Moreover, HSCs lacking Msi2 are severely impaired in competitive repopulation experiments. We further found that Msi2 is expressed during embryo development in the CD41+ cells in the Aorta-Gonada Mesonephros (AGM), most probably corresponding to the earliest emerging HSCs. Also deficient Msi2 embryos have a decrease in the number of fetal liver HSPCs. Lastly, our experiments show that Msi2 deficient HSPCs have a defect in the Wnt and PTEN/PI3K/Akt pathways that could explain the phenotype observed. Altogether, my thesis provides novel insight in to the role and mechanism of action of Musashi-2 in mouse HSPCs.<br>La producción de células sanguíneas a lo largo de toda la vida se lleva a cabo gracias a las células madre hematopoyéticas y células progenitoras (HSPC) que residen en la médula ósea. El estudio de los genes que controlan cómo estas HSPCs trabajan para sostener la producción continua de las células de la sangre permitirán el desarrollo de nuevos protocolos basados en la expansión ‘in vitro’ de estas células para terapias de transplante. Hemos utilizado un cribado basado en el fenómeno de integración retroviral para buscar nuevos genes que regulan la función de células madre hematopoyéticas (HSC). Uno de los genes encontrados fue Musashi 2 (Msi2), una proteína de unión a ARN que puede actuar como un inhibidor de la traducción. El modelo de ratón desarrollado mediante “gene-trap” y que inactiva el gen, muestra que Msi2 está más expresado en HSCs de largo plazo (LT-HSC) y corto plazo (ST-HSC), así como en los progenitores linfoides-mieloides (LMPP), y su expresión disminuye en progenitores intermedios y células maduras. Los ratones deficientes para Msi2 son completamente viables, pero presentan defectos importantes en los precursores primitivos que se agravan con la edad. El análisis de ciclo celular y de expresión génica sugieren que el principal defecto hematopoyético en ratones con esta deficiencia consiste en una disminución de la capacidad de proliferación de ST-HSCs y LMPPs. Además, las HSCs con déficit de Msi2 no son capaces de repoblar la médula ósea cuando se transplantan junto a médula procedente de ratones “wild-type”. También hemos observado que Msi2 se expresa durante el desarrollo del embrión en las células CD41 + de la Aorta-Gonada Mesonefros (AGM), correspondiendo muy probablemente a las HSCs emergentes. Además los embriones deficientes para Msi2 tienen una disminución en el número de HSPC en hígado fetal. Por último, nuestros experimentos muestran que un déficit de Msi2 en las HSPCs provoca un defecto en las vías Wnt y PTEN / PI3K / Akt; esto podría explicar el fenotipo observado en estos ratones. En conjunto, mi tesis proporciona una nueva perspectiva sobre el papel y el mecanismo de acción de Musashi-2 en HSPCs de ratón.
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Williams, Emma Samantha. "Characterisation of the schizosaccharomyces pombe MSI1-like protein Prw1." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443990.
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Coquery, Nicolas [Verfasser]. "Intrahippocampal transplantation of MSC and MSC-expressing BDNF in Rat Models of Depression-like Behaviour / Nicolas Coquery." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023665360/34.
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Keller, Stefan. "Aufbau eines Spurtriggers bei HERA-B mit GEM-MSGC-Detektoren." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962686336.
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Moffett, Peter. "Characterisation of the transcriptional properties of the mSim gene products." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0031/NQ64623.pdf.
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Moffett, Peter. "Characterisation of the transcriptional properties of the mSim gene products." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36659.
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The basic-Helix-Loop-Helix PAS (bHLH-PAS) protein family is a growing family of transcription factors. Included in this family is the Drosophila single-minded (DSim) gene, which is critical for the development of the CNS midline cells.<br>We have isolated a murine homologue of the Drosophila Sim gene, mSim-2. The murine and Drosophila gene products share a high degree of homology in the bHLH and PAS regions but not within the carboxy terminus. Northern blot and RT-PCR analysis of adult murine tissues revealed that the mSim-2 is expressed at the highest levels in the kidneys and at lower levels is present in skeletal muscle, lung, testis, brain, and heart. In situ hybridisation experiments demonstrate that mSim-2 is also expressed in early fetal development in the central nervous system and in cartilage primordia.<br>We investigated the ability of mSIM-2 to associate with the Arnt gene product, a common dimerisation partner of a number of bHLH-PAS proteins. We found that the HLH and PAS motifs of both proteins are required for optimal association. We demonstrated the presence of two separable repression domains within the carboxy terminus of mSIM-2, in contrast to dSIM, which is a transactivator. We find that mSIM-2 is also capable of repressing activation by its binding partner, ARNT. We also demonstrate that mSIM-2 can functionally interfere with another bHLH-PAS transcription factor, HIF-1alpha, by competing for ARNT binding, providing a second mechanism by which mSIM-2 may inhibit transcription.<br>We also investigated the effects of mSIM-2 and its close paralogue mSIM-1, as heterodimers with ARNT, on reporter constructs containing native DNA binding sites. We find that mSIM-1 can effect transcriptional activation through it's association with ARNT. In contrast, mSIM-2/ARNT does not activate, as the mSIM-2 repression domains quench ARNT transactivation. We also find that the mSIM-2 can interfere with mSIM-1 mediated transactivation by competing for dimerisation with ARNT and for DNA binding site occupation. Our results suggest that mSIM-1 and mSIM-2 have similar dimerisation and DNA binding properties but different transcriptional effects and may therefore antagonise each other which may in turn be a mechanism of gene regulation by these two proteins.
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Loney, Erica. "PhoR, PhoP and MshC: Three essential proteins of Mycobacterium tuberculosis." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1396606314.
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Boman, Trotte, and Samuel Jangenstål. "Beating the MSCI USA Index by Using Other Weighting Techniques." Thesis, KTH, Matematisk statistik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-209258.
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In this thesis various portfolio weighting strategies are tested. Their performance is determined by their average annual return, Sharpe ratio, tracking error, information ratio and annual standard deviation. The data used is provided by Öhman from Bloomberg and consists of monthly data between 1996-2016 of all stocks that were in the MSCI USA Index at any time between 2002-2016.For any given month we use the last five years of data as a basis for the analysis. Each time the MSCI USA Index changes portfolio constituents we update which constituents are in our portfolio. The traditional weighting strategies used in this thesis are market capitalization, equal, risk-adjusted alpha, fundamental and minimum variance weighting. On top of that, the weighting strategies are used in a cluster framework where the clusters are constructed by using K-means clustering on the stocks each month. The clusters are assigned equal weight and then the traditional weighting strategies are applied within each cluster. Additionally, a GARCH-estimated covariance matrix of the clusters is used to determine the minimum variance optimized weights of the clusters where the constituents within each cluster are equally weighted. We conclude in this thesis that the market capitalization weighting strategy is the one that earns the least of all traditional strategies. From the results we can conclude that there are weighting strategies with higher Sharpe ratio and lower standard deviation. The risk-adjusted alpha in a traditional framework performed best out of all strategies. All cluster weighting strategies with the exception of risk-adjusted alpha outperform their traditional counterpart in terms of return.<br>I denna rapport prövas olika viktningsstrategier med målet att prestera bättre i termer av genomsnittlig årlig avkastning, Sharpekvot, aktiv risk, informationskvot och årlig standardavvikelse än det marknadsviktade MSCI USA Index. Rapporten är skriven i samarbete med Öhman och data som används kommer från Bloomberg och består av månadsvis data mellan 1996-2016 av alla aktier som var i MSCI USA Index vid någon tidpunkt mellan 2002-2016. För en given månad används senaste fem åren av historisk data för vår analys. Varje gång som MSCI USA Index ändrar portföljsammansättning så uppdaterar vi vilka värdepapper som ingår i vår portfölj. De traditionella viktningsstrategierna som används i denna avhandling är marknadviktat, likaviktat,risk-justerad alpha viktat, fundamental viktat och minsta varians viktat. De klusterviktade strategierna som används i denna avhandling är konstruerade genom att använda K-medel klustring på aktierna varje månad, tilldela lika vikt till varje kluster och sedan använda traditionella viktningsstrategier inom varje kluster. Dessutom används en GARCH skattad kovariansmatris av klustrena för att bestämma minsta varians optimerade vikter för varje kluster där varje aktie inom alla kluster är likaviktade. Vi konstaterar i detta arbete att den marknadsviktade strategin har lägst avkastning av alla viktningsmetoder. Från resultaten kan vi konstatera att det _nns viktningsmetoder med högre Sharpekvot och lägre standardavvikelse. Risk-justerad alpha viktning använt på traditionellt vis är den strategi som presterar bäst av alla metoder. Alla klusterviktade strategier med undantag av risk-justerad alpha viktning presterar bättre än deras traditionella motsvarighet i termer av avkastning.
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Fernström, Dan. "Generering av MSI-paket : En alternativ installationslösning." Thesis, University of Kalmar, School of Communication and Design, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-448.
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<p>Denna rapport beskriver Windows Installer och hur dess API kan användas för att generera MSI-paket. Det förklaras hur MSI-paket bör vara utformade och hur dessa kan användas.</p><p>Projektet resulterade i en prototyp åt uppdragsgivaren Capitex AB. Prototypen kunde användas för att generera MSI-paket för applikationen Säljstöd.</p>
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Gowthaman, Rahul, and Suhail Jagwani. "Advanced bushing script program in MSC ADAMS." Thesis, KTH, Fordonsdynamik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-243489.
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The thesis focuses on investigating and optimizing a bushing script implemented as a tool in MSC ADAMS/Car. The study provides an insight on the representation of a rubber bushing and identify parameters which can be used to define the properties of a bushing in a simulation environment such as ADAMS/Car. The tool being studied here can be used to implement different kind of bushings such as a hydro bushing and a general rubber bushing, but optimization was implemented for the rubber bushing only. With an increasing reliance on Computer Aided Engineering (CAE) tools in the designing process, it is necessary that the vehicle behaviour can be predicted without relying on physical testing. CAE tools reduces the need of prototypes and provides a faster approach to designing vehicles. MSC ADAMS/Car is one such tool, which has been used here to predict the vehicle dynamic behaviour, which will influence the ride, handling and comfort characteristics of the vehicle. Rubber bushings, which have been studied here, have a significant contribution to the overall stiffness of the vehicle and as such, it is imperative that the tool being used here, is accurate and makes the designing process easy. The rubber bushing can be imagined to be a combination of a non-linear elastic spring, a frequency dependent Maxwell component and an amplitude dependent frictional element. In order to ease the design of the bushing properties, a reduced number of input properties are used to calculate the bushing properties internally. While trying to validate the force hysteresis loop obtained through the model with the measured data, it was seen that the accuracy was quite poor for the model when loading it with dynamic loads corresponding to amplitudes of0.2 mm and lower. The quasi-static loading and dynamic loading above 0.2 mm is shown to have a satisfactory accuracy when compared to the measured data.
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Philippe, Pascal. "MAXIM, un macrosimulateur de circuits MSI, LSI." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37608792q.
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Jentsch, Lothar, and David Natroshvili. "Three-dimensional mathematical Problems of thermoelasticity of anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800967.
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CHAPTER I. Basic Equations. Fundamental Matrices. Thermo-Radiation Conditions
1. Basic differential equations of thermoelasticity theory
2. Fundamental matrices
3. Thermo-radiating conditions. Somigliana type integral representations
CHAPTER II. Formulation of Boundary Value and Interface Problems
4. Functional spaces
5. Formulation of basic and mixed BVPs
6. Formulation of crack type problems
7. Formulation of basic and mixed interface problems
CHAPTER III. Uniqueness Theorems
8. Uniqueness theorems in pseudo-oscillation problems
9. Uniqueness theorems in steady state oscillation problems
CHAPTER IV. Potentials and Boundary Integral Operators
10. Thermoelastic steady state oscillation potentials
11. Pseudo-oscillation potentials
CHAPTER V. Regular Boundary Value and Interface Problems
12. Basic BVPs of pseudo-oscillations
13. Basic exterior BVPs of steady state oscillations
14. Basic interface problems of pseudo-oscillations
15. Basic interface problems of steady state oscillations
CHAPTER VI. Mixed and Crack Type Problems
16. Basic mixed BVPs
17. Crack type problems
18. Mixed interface problems of steady state oscillations
19. Mixed interface problems of pseudo-oscillations
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Jentsch, L., D. Natroshvili, and I. Sigua. "Mixed Interface Problems of Thermoelastic Pseudo-Oscillations." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801150.
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Three-dimensional basic and mixed interface problems of the mathematical
theory of thermoelastic pseudo-oscillations are considered for piecewise homogeneous
anisotropic bodies. Applying the method of boundary potentials and the theory of
pseudodifferential equations existence and uniqueness theorems of solutions are proved
in the space of regular functions C^(k+ alpha) and in the Bessel-potential (H^(s)_(p))
and Besov (B^(s)_(p,q)) spaces. In addition to the classical regularity results
for solutions to the basic interface problems, it is shown that in the mixed interface
problems the displacement vector and the temperature are Hölder continuous with
exponent 0<alpha<1/2.
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Jentsch, L., and D. Natroshvili. "Interaction between Thermoelastic and Scalar Oscillation Fields (general anisotropic case)." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801162.
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Three-dimensional mathematical problems of the interaction between thermoelastic
and scalar oscillation fields are considered in a general anisotropic case. An elastic
structure is assumed to be a bounded homogeneous anisortopic body occupying domain
$\Omega^+\sub\R^3$ , where the thermoelastic field is defined, while in the
physically anisotropic unbounded exterior domain $\Omega^-=\R^3\\ \overline{\Omega^+}$
there is defined the scalar field. These two fields
satisfy the differential equations of steady state oscillations in the corresponding
domains along with the transmission conditions of special type on the interface
$\delta\Omega^{+-}$. Uniqueness and existence theorems, for the non-resonance case, are proved
by the reduction of the original interface problems to equivalent systems of boundary
pseudodifferential equations ($\Psi DEs$) . The invertibility of the corresponding
matrix pseudodifferential operators ($\Psi DO$) in appropriate functional spaces is
shown on the basis of generalized Sommerfeld-Kupradze type thermoradiation conditions
for anisotropic bodies. In the resonance case, the co-kernels of the $\Psi DOs$ are
analysed and the efficent conditions of solvability of the transmission problems
are established.
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Bouveret, Romaric. "Arabidopsis MSI1 is essential for embryonic development and flowering-time control /." Zürich : ETH, 2005. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=16184.
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Schweickert, H. [Verfasser]. "Messung magnetischer Kernmomente kurzlebiger Radionuklide. Beispiel: 408 msec Na²⁰ / H. Schweickert." Karlsruhe : KIT-Bibliothek, 2009. http://d-nb.info/1186905603/34.
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Jentsch, L., and D. Natroshvili. "Thermoelastic Oscillations of Anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800871.
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The generalized radiation conditions at infinity of Sommerfeld-Kupradze type are established in the theory of thermoelasticity of anisotropic bodies. Applying the potential method and the theory of pseudodifferential equations on manifolds the uniqueness and existence theorems of solutions to the basic three-dimensional exterior boundary value problems are proved and representation formulas of solutions by potential type integrals are obtained.
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Yang, Kangjie Roy. "Simulation of hydrodynamic ram phenomenon using MSC Dytran." Thesis, Monterey, California: Naval Postgraduate School, 2014. http://hdl.handle.net/10945/44033.
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Approved for public release; distribution is unlimited<br>Hydrodynamic ram (HRAM) refers to the damage process due to high pressures generated when a high-velocity projectile penetrates a compartment or vessel containing a fluid. A Finite Element model was developed using MSC Dytran to investigate the structural response during the initial phase of HRAM and conduct parametric studies on factors that could affect the tank wall response. The Lagrangian structural shell elements were coupled to the fluid Euler elements using the ALE coupling technique, whereas the projectile was coupled to the fluid using the general coupling technique. This study focused mainly on the structural back wall response where critical components or main structural members on the aircraft could be located. Results from this study show that initial shock wave pressure upon projectile impact is unlikely to have detrimental effects on the exit wall of tank due to its rapid extinction in the fluid. The presence of free surface with lower filling levels reduced both the initial shock pressure and subsequent drag phase pressure. Projectile mass was found to have a strong effect on the exit wall response during the shock phase, but once projectile penetrated the entry wall, results for the drag phase for different projectile mass investigated were inconclusive. Other factors examined included the tank’s material properties and fluid density. Of all the factors being studied, projectile’s velocity was found to have the strongest influence on exit wall response and fluid pressures. Therefore, the damage to exit wall of the tank could be greatly reduced if the entry wall is able to slow the projectile significantly.
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Mukonoweshuro, Blessing. "Immunogenicity of allogeneic mouse mesenchymal stem cells (MSC)." Thesis, University of Leeds, 2012. http://etheses.whiterose.ac.uk/4140/.
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Adult mesenchymal stem cells (MSC) are multipotential cells which can differentiate into various cell types thus giving them utility in tissue engineering regenerative medicine and cell-based therapies. Use of allogeneic MSC offers the prospect of 'off-the-shelf' tissue engineered products and tailor-made 'designer'-therapies with huge benefits to patients and industry. However, their immunological properties are poorly defined and this has hampered their potential clinical utility. Recent studies have suggested that allogeneic MSC are immunoprivileged in addition to possessing immunosuppressive properties. Interestingly, dermal fibroblasts (DF) have also been suggested to be functionally similar to MSC although their immunological properties are controversial. This study sought to systematically investigate the immunomodulatory properties of allogeneic MSC, namely (i) immunosuppression and (ii) (immunogenicity of allogeneic MSC before and after differentiation using an allogeneic mouse model which employed two genetically distinct strains; Balb/c (H2 d) and C3H (H2 k) which are used as responder (recipient) and stimulator (donor) respectively. Immunosuppressive properties were investigated using adaptations of the one-way mixed lymphocyte reaction (MLR) while the immunogenicity was tested using the lymphocyte transformation assays (LTA). DF were similarly tested for comparison. MSC and DF were successfully isolated from the bone marrow and abdominal skin respectively of Balb/c and C3H mice, expanded and characterised by flow cytometry. MSC expressed MHC I, Sca-1, CD29, CD44, CD90.2 and CD105 but not MHC II, CD11b, CD34, CD45, CD80 and CD86. In contrast to MSC, DF were negative for CD29, CD44 and CD105. Both MSC and DF successfully differentiated into adipocytes, chondrocytes and osteocytes in the tri-lineage test; the benchmark test for stem cells. Various parameters including medium changes, cell viability following mitotic inactivation of stimulator cells, type and concentration of serum for medium supplementation, responder to stimulator cell ratio and total cell numbers were tested to determine appropriate conditions for carrying out the MLR and LTA. With regard to the immunosuppressive properties, both syngeneic and allogeneic MSC significantly suppressed one-way MLR and two-way MLR. DF also exhibited similar suppressive potency. In LTA, allogeneic, but not syngeneic MSC stimulated Balb/c lymphocyte proliferation. Interestingly, both syngeneic and allogeneic DF failed to stimulate lymphocyte proliferation. Following chondrogenic differentiation, both syngeneic and allogeneic MSC and DF suppressed one-way MLR, albeit with reduced potency. With regard to their immunogenicity, allogeneic MSC and DF, but not syngeneic MSC and DF significantly stimulated lymphocyte proliferation. Therefore, it was concluded that both allogeneic MSC and DF possess immunosuppressive properties before and after differentiation. Undifferentiated and differentiated allogeneic MSC and differentiated DF however, may not be immunoprivileged. Thus the clinical utility of allogeneic MSC may be limited by their immunogenicity.
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Jung, M., and U. Rüde. "Implicit extrapolation methods for multilevel finite element computations." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800516.
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Extrapolation methods for the solution of partial differential equations are commonly based on the existence of error expansions for the approximate solution. Implicit extrapolation, in the contrast, is based on applying extrapolation indirectly, by using it on quantities like the residual. In the context of multigrid methods, a special technique of this type is known as \034 -extrapolation. For finite element systems this algorithm can be shown to be equivalent to higher order finite elements. The analysis is local and does not use global expansions, so that the implicit extrapolation technique may be used on unstructured meshes and in cases where the solution fails to be globally smooth. Furthermore, the natural multilevel structure can be used to construct efficient multigrid and multilevel preconditioning techniques. The effectivity of the method is demonstrated for heat conduction problems and problems from elasticity theory.
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Natroshvili, David, and Shota Zazashvili. "The Interface Crack Problem for Anisotropic Bodies." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800979.
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The two-dimensional interface crack problem is investigated for anisotropic bodies in the Comninou formulation. It is established that, as in the isotropic case, properly incorporating contact zones at the crack tips avoids contradictions connected with the oscillating asymptotic behaviour of physical and mechanical characteristics leading to the overlapping of material. Applying the special integral representation formulae for the displacement field the problem in question is reduced to the scalar singular integral equation with the index equal to -1. The analysis of this equation is given. The comparison with the results of previous authors shows that the integral equations corresponding to the interface crack problems in the anisotropic and isotropic cases are actually the same from the point of view of the theoretical and numerical analysis.
28
Edmonds, Carole A. "The relationship of the MSIP curriculum standard evaluation process and student achievement /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974626.
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Silva, Mancilla Ignacio Tomás. "Cómo reaccionan los mercados LATAM a rebalanceos de los índices MSCI locales." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/169780.
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Memoria para optar al título de Ingeniero Civil Industrial<br>Los índices accionarios son una pieza fundamental de información para los inversionistas ya que, son indicadores del desempeño financiero de regiones geográficas, industrias u otras empresas según tamaño por ejemplo. Un distribuidor global de servicios financieros como estos índices es MSCI. Los índices de esta empresa, debido a su estructura estándar y nivel global, son los más seguidos por los inversionistas.
Como el objetivo de estos índices es ser representativos de los mercados. MSCI se hace cargo de esto de manera dinámica a través de los rebalanceos trimestrales de índices que poseen dos partes: primero, un anuncio de los cambios a ser efectuados; y segundo, su posterior ejecución alrededor de 2 semanas más tarde.
Se ha evidenciado en la literatura que los inversionistas reaccionan frente a estos eventos. Hipótesis como presión temporal sobre el precio o el supuesto de que el evento conlleva información no pública tratan de explicar esta situación.
Este trabajo se propone verificar la existencia de este efecto a plazos de 5, 10 y 20 días previo y posterior a los eventos en Latinoamérica, cuantificarlo y verificar si los mercados reaccionan de igual forma a lo observado en la literatura.
Se realizó un estudio de evento entorno a la fecha de anuncio y de rebalanceo efectivo efectuado por MSCI trimestralmente, modelando los retornos de acuerdo al modelo de 4 factores de Carhart (1997). De acuerdo a la desviación de los retornos ocurridos y los estimados en torno a los eventos, se definen los retornos anormales y se evalúa su significancia estadística.
Se verificó la existencia de retornos anormales para el periodo previo a la fecha de rebalanceo efectivo en el grueso de los mercados estudiados, tanto para el caso de subida de ponderación como de bajada. De igual forma, el día del evento existe un reversal aunque no completo de los rendimientos anormales de los papeles. Por el contrario, no se evidencia un comportamiento que indique la predicción de parte de los inversionistas al evento de anuncio, sino más bien, existe una reacción al día del anuncio que se refleja en los días posteriores.
Sin perjuicio de lo anterior, existen discrepancias en los resultados entre los mercados Latinoamericanos. Se muestra un efecto más consistente y significativo para Brasil, Chile y México que para Argentina, Colombia o Perú.
Se propone extender la investigación mediante una discrimanción según magnitud de rebalanceo y cambio en las ventanas de tiempo estudiado, se sugiere aislar el estudio post crisis subprime.
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Hermansson, Johan, and Christian Svensson. "Det pedagogiska arbetet inom MSI : Utifrån Bolognaprocessen och UPC." Thesis, Växjö University, School of Mathematics and Systems Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-746.
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<p>The Pedagogical progression within MSI – Based upon The Bologna Process and UPC.</p><p>In a near future several of the European countries will begin working after new guidelines concerning a declaration called the Bologna process. Everything will be done one step at a time and the declaration will change the way the students are being graded, all this for the sake of making the European labour-market more</p><p>opened for all of its millions of students.</p><p>In Växjö this process is in the making, but to adapt to the future demands the school must also change its ways of teaching.</p><p>To increase its quality the University has put together a procedure of actions to improve the pedagogical working method in all its institutions. In this essay we would like to elucidate how the work with the Bologna process is proceeding within the institution of Mathematics and System Engineering and what</p><p>they do improve their pedagogical teaching. By doing a qualitative case study on the student at the Computer Science Program we wish to find the answers to our questions.</p><br><p>Det pedagogiska arbetet inom MSI – Utifrån Bolognaprocessen och UPC.</p><p>Inom en snar framtid kommer flertalet länder i Europa jobba efter nya riktlinjer enligt en deklaration kallad Bolognaprocessen. Det hela kommer att ske i etapper och innebär att sättet på vilket studenter bedöms kommer ändras, allt för att göra Europas arbetsmarknad öppnare för alla dess miljoner studerande.</p><p>I Växjö pågår detta arbete för fullt, men för att anpassa sig till framtida krav måste skolan även förändra sin utbildningsform. För att höja sin kvalité har universitetet tagit fram en handlingsplan för att förbättra de pedagogiska arbetsmetoderna i alla institutioner. I den här uppsatsen vill vi belysa hur arbetet med Bolognaprocessen fortgår inom Matematiska och systemtekniska institutionen och vad de gör för att förbättra den</p><p>pedagogiska undervisningen. Genom att göra en kvalitativ undersökning med Systemvetenskapliga programmets studenter försöker vi finna svaren på våra frågor.</p>
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Wang, Longlong. "A mesenchymal stem cell (MSC) niche in mouse incisor." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/a-mesenchymal-stem-cell-msc-niche-in-mouse-incisor(8f92b75d-f90f-4c58-ab06-682af9f90e95).html.
Full textAbstract:
Mesenchymal stem cells (MSCs) are heterogeneous cell populations that are identified by their in vitro characteristics while their biological properties and in vivo identities are often less understood. Different from human teeth, mouse incisors grow and erupt continuously throughout their lives and compensate for daily abrasions with the existence of stem cells. However, the precise location of the mesenchymal stem cells (MSCs) in the incisor is unclear. Generally, the MSCs in the mouse incisor are believed to be located in the mesenchyme close to the epithelium cervical loops, since the growth and differentiation of the incisor always initiates at the apical end and extends towards the incisal end. The utilization of label-retaining experiments and transgenic reporter mouse lines has enabled further understanding of the less established identities and properties of dental pulp stem cells in vivo. The work described in this thesis demonstrates that the mesenchymal stem cell niche located at the apical end of mouse incisor contains three distinct but connected cell populations: 1) a slow cycling cell population containing Thy-1+ cells essential for tooth dental pulp and odontoblast formation 2) a Ring1/Bcor-associated fast cycling cell population crucial for maintaining tissue growth and homeostasis of epithelium stem cells in labial cervical loop 3) a quiescent long-term cell population marked by Flamingo homologue Celsr1 might respond to generate new stem cells when the stem cells become depleted.
32
Genest, Blaise. "L'odyssée des graphes de diagrammes de séquences ( MSC-Graphes)." Paris 7, 2004. http://www.theses.fr/2004PA077210.
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Rotzer, Daniel. "Momentum strategies Analysis of sector and regional index momentum strategies on MSCI basis /." St. Gallen, 2008. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02602019002/$FILE/02602019002.pdf.
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Teixeira, Fernando Henrique Pisani. "Metodologia para projeto, construção e ensaios em máquina síncrona de imã permanente - MSIP." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/18/18133/tde-27112006-085220/.
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A grande aplicação residencial de motores de indução monofásicos é em sistemas de refrigeração doméstica/comercial. O desenvolvimento de motores mais eficientes, associado ao controle de velocidade, fez com que, dentro os mais diversos tipos de motores, o motor síncrono de imã permanente tornasse objeto para a criação de uma metodologia de projeto, construção e realização de ensaios. Assim, para adequar o projeto do motor MSIP para substituição do motor de indução monofásico, foram feitos estudos de como aproveitar as laminações já existentes, através de definições das características básicas do estator e do rotor. O imã permanente a ser utilizado foi definido principalmente em função do custo do material e de suas propriedades magnéticas estarem adequadas à necessidade do projeto. O projeto magnético foi feito para maximizar o fluxo nos dentes, considerando as características construtivas e a curva de trabalho dos imãs. O projeto elétrico, a partir de um circuito equivalente do motor, permitiu explicar as relações de torque, corrente e tensão do motor MSIP, bem como a definição das bobinas do motor, quanto ao espaçamento destas entre as ranhuras, o cálculo do número de espiras e o diâmetro dos fios em função da área permitida pela ranhura da lamina do estator. Com as informações obtidas após o cálculo do motor MSIP, passou-se a construção de um protótipo constituído pelo estator, rotor e um sistema de suporte que permitisse o levantamento dos parâmetros do motor. Os parâmetros necessários foram definidos levando-se em consideração a necessidade para o projetista do conversor elétrico, sendo estes dados utilizados em simulações computacionais para a determinação do projeto do acionador. Com isto, os ensaios do motor MSIP permitiram o levantamento dos seguintes parâmetros: resistência, indutância, curvas de tensão de fase e linha da eletromotriz por velocidade em diversas rotações, momento de inércia e atrito viscoso, concluindo assim a proposta deste trabalho, e finalizando a metodologia para o motor MSIP.<br>A major residential application of single-phase induction motors is in domestic refrigeration. The development of more efficient motors, associated with speed control, has made that, among the most diverse types of electrical motors, the permanent magnet synchronous machine becomes an object of study for a design, construction and testing methodology. Therefore, to suit the PMSM design to replace the single phase induction motor, studies were made on how to take advantage of existing laminations, through definitions of the basic characteristics of the stator and rotor. The permanent magnet used was defined mainly as a function of the cost of the material and its magnetic properties since they suit the design requirements. PMSM magnetic design was made to maximize the magnetic flow in the slots considering the constructive characteristics and the magnet curve. The electric design, starting from a motor equivalent circuit, allowed to explain torque, current and voltage of the PMSM motor, as well as the definition of the motor windings regarding their filling in the slots, the calculation of coil number and the wire diameter as a function of the area allowed by the stator lamination slot. With the information obtained after the PMSM motor calculation, a prototype construction was initiated consisting of the stator, rotor and a support system to allow determining the motor parameters. The required parameters were defined taking into account the need the designer had of an electronic drive had. This data was used in computational simulations to determine the electronic driver design. After this, the motor testing allowed to identify the parameters, namely: winding resistance and inductance, various speed curves versus phase to phase and line voltage for back emf´s, moment of inertia and viscous friction, thus completing this work proposal, finalizing the project methodology for PMSM motor.
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Leonard, Martha Maria. "A description of final year nursing students' ability to recognize abnormal vital signs recordings and clinical decision-making process." Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/6663.
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Includes abstract.<br>Includes bibliographical references.<br>The aim of this study was to determine whether final year nursing students can recognize and respond to abnormal vital sign recordings, and to analyse their clinical decision-making processes.
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Pester, M. "Grafik-Ausgabe vom Parallelrechner für 2D-Gebiete." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800602.
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The paper mainly describes the user interface of some graphical
visualization tools for parallel finite element applications in
2D (layer problems, deformation problems, fluid dynamics). There
are presented some examples of various methods to display the
numerical results.
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Meyer, M. "Grafik-Ausgabe vom Parallelrechner für 3D-Gebiete." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800669.
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The paper describes a method for Visualization of computational results in parallel finite element applications for 3D problems. The visualization itself is done on a workstation using a post- processing tool based on GRAPE, which interacts with the parallel program to obtain data.
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Apel, T., G. Haase, A. Meyer, and M. Pester. "Parallel solution of finite element equation systems: efficient inter-processor communication." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800670.
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This paper deals with the application of domain decomposition methods for the parallel solution of boundary value problems for partial differential equations over a domain $Omegabset R^d$, $d=2,3$. The attention is focused on the conception of efficient communication routines for the data exchange which is necessary for example in the preconditioned cg-algorithm for solving the resulting system of algebraic equations. The paper describes the data structure, different algorithms, and computational tests.
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Ivanov, S. A., and V. G. Korneev. "On the preconditioning in the domain decomposition technique for the p-version finite element method. Part I." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800856.
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Abstract P-version finite element method for the second order elliptic equation in an arbitrary sufficiently smooth domain is studied in the frame of DD method. Two types square reference elements are used with the products of the integrated Legendre's polynomials for the coordinate functions. There are considered the estimates for the condition numbers, preconditioning of the problems arising on subdomains and the Schur complement, the derivation of the DD preconditioner. For the result we obtain the DD preconditioner to which corresponds the generalized condition number of order (logp )2 . The paper consists of two parts. In part I there are given some preliminary re- sults for 1D case, condition number estimates and some inequalities for 2D reference element.
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Reichel, U. "Partitionierung von Finite-Elemente-Netzen." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801107.
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The realization of the finite element method on parallel computers
is usually based on a domain decomposition approach. This paper is
concerned with the problem of finding an optimal decomposition and an
appropriate mapping of the subdomains to the processors. The quality
of this partitioning is measured in several metrics but it is also
expressed in the computing time for solving specific systems of
finite element equations.
The software environment is first described. In particular, the data
structure and the accumulation algorithm are introduced. Then
several partitioning algorithms are compared. Spectral bisection was
used with different modifications including Kernighan-Lin refinement,
post-processing techniques and terminal propagation. The final
recommendations should give good decompositions for all finite
element codes which are based on principles similar to ours.
The paper is a shortened English version of Preprint SFB393/96-18
(Uwe Reichel: Partitionierung von Finite-Elemente-Netzen), SFB 393,
TU Chemnitz-Zwickau, December 1996. To be selfcontained, some material
of Preprint SPC95_5 (see below) is included. The paper appeared as
Preprint SFB393/96-18a, SFB 393, TU Chemnitz-Zwickau, January 1997.
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Grabitz, Martin. "Zur Konstruktion einfacher Charaktere und der Fortsetzungen ihrer Heisenbergdarstellungen für lokale zentral-einfache Algebren." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2000. http://dx.doi.org/10.18452/14482.
Full textAbstract:
In dieser Dissertationsschrift soll erkl{\"a}rt werden, wie auf der Grundlage von einfachen Strata, wie sie in einer gemeinsamen Arbeit mit Broussous \cite{BG} betrachtet wurden, einfache Charaktere f{\"u}r lokale einfache Algebren konstruiert werden k{\"o}nnen, wobei die Konstruktion den Vorbildern von Bushnell und Kutzko im zerfallenden Fall \cite{BK1} und von Zink \cite{Z7} im Falle eines Schiefk{\"o}rpers folgt. Der Begriff des einfachen Charakters geht auf die Arbeit \cite{BK1} zur{\"u}ck und bezeichnet eine ausgezeichnete Auswahl von Heisenbergcharakteren, die zu einem stabilen Darstellungsfilter geh{\"o}ren, der gem{\"a}{ss} \cite{Z2}(Hauptsatz 1.4) einem Darstellungsfilter zugeordnet wird, der zu einer absteigenden Normalreihe $$1+\R\supset1+\R^2\supset\ldots$$ geh{\"o}rt, wobei $\R$ das Jacobsonradikal einer erblichen Ordnung bezeichnet. Wir werden hier nur von Hauptordnungen ausgehen, d.h. von dem Fall, da{ss} $\R$ und seine Potenzen gebrochene Hauptideale sind. Diese Vorgehensweise und auch die besondere Auswahl der Heisenbergcharaktere in Form von einfachen Charakteren, wird durch die Konstruktion im Falle eines Schiefk{\"o}rpers \cite{Z7} und durch den abstrakten Matchingsatz \cite{BDKV} gerechtfertigt. Im Falle eines lokalen zentralen Schiefk{\"o}rpers ist n{\"a}mlich der Bewertungsring die einzige erbliche Ordnung und die einfachen Charaktere sind alle Heisenbergcharaktere die zu einem stabilen Darstellungsfilter geh{\"o}ren, der gem{\"a}{ss} \cite{Z2}(Hauptsatz 1.4) einem Darstellungsfilter, der zur absteigenden Normalreihe $$1+\pin_D\supset1+\pin_D^2\supset\ldots$$ geh{\"o}rt, zugeordnet wird, wobei $\pin_D$ das Bewertungsideal des Schiefk{\"o}rpers $D$ bezeichnet. Der abstrakte Matchingsatz liefert nun die Existenz einer Bijektion zwischen den irreduziblen glatten Darstellungen der multiplikativen Gruppe des lokalen zentralen Schiefk{\"o}rpers $D$ und den irreduziblen quadratintegrierbaren glatten Darstellungen einer beliebigen anderen lokalen zentraleinfachen Algebra vom selben reduzierten Grad {\"u}ber demselben nicht-archimedischen Grundk{\"o}rper $F$, welche den Charakter einer Darstellung in dem Sinne erh{\"a}lt, da{ss} die Charakterwerte auf den Konjugationsklassen elliptischer Elemente der verschiedenen Algebren, welche mithilfe ihrer Minimalpolynome identifiziert werden k{\"o}nnen, bis auf ein Vorzeichen {\"u}bereinstimmen. Wir werden hier kanonische Bijektionen zwischen den einfachen Charakteren f{\"u}r verschiedene zentraleinfache Algebren vom selben reduzierten Grad {\"u}ber demselben Grundk{\"o}rper angeben, von denen wir erwarten, da{ss} sie mit der Abbildung des abstrakten Matchingsatzes vertr{\"a}glich sind. Das dieses in der Tat der Fall ist, wurde bisher nur in einfachen F{\"a}llen wie \cite{He} und \cite{BH2} gezeigt, jedoch wurde in der Arbeit \cite{Z4} bereits mithilfe der Konstruktionen von \cite{Z7} und \cite{BK3} eine Bijektion zwischen den irreduziblen glatten Darstellungen der multiplikativen Gruppe des lokalen zentralen Schiefk{\"o}rpers $D$ vom Index $N$ {\"u}ber einem Grundk{\"o}rper $F$ und den irreduziblen essentiell quadratintegrierbaren glatten Darstellungen von $Gl_N(F)$ konstruiert, welche den Artinf{\"u}hrer und den formalen Grad einer Darstellung erh{\"a}lt. Da die Abbildung des abstrakten Matchingsatzes dieselben Forderungen erf{\"u}llt, kommt dies der gew{\"u}nschten Vertr{\"a}glichkeit schon sehr nahe und wir erf{\"u}llen mit unserer Konstruktion insbesondere die in der Arbeit \cite{Z4} gemachte Forderung die dort im Bezug auf die einfachen Charaktere getroffen Auswahlen noch unabh{\"a}ngiger von den jeweiligen Algebren zu gestalten. Die hier getroffene Auswahl wird durch die Verwendung sogenannter spezieller approximierender Folgen getroffen, welche sich aus einer Verallgemeinerung der in \cite{BG} gemachten {\"U}berlegungen ergeben. Im Anschlu{ss} an die Konstruktion und den Vergleich einfacher Charaktere werden wir in einer gro{ss}en Anzahl von F{\"a}llen zeigen, da{ss} sich die Heisenbergdarstellungen, die wir zu den einfachen Charakteren erhalten, in kanonischer Weise fortsetzen lassen und wir erwarten von diesen Fortsetzungen, da{ss} sie analoge Eigenschaften besitzen, wie die sogenannten ``$\beta$-Fortsetzungen'' von \cite{BK1}(5.2.1) im zerfallenden Fall. Damit k{\"o}nnen wir in diesen F{\"a}llen eine Liste von hypothetischen einfachen Typen angeben, von denen wir vermuten, da{ss} sie alle Bernsteinkomponenten parametrisieren, welche irreduzible essentiell quadratintegrierbare Darstellungen enthalten. Insbesondere vermuten wir, da{ss} sich die supercuspidalen Darstellungen mittels kompakter Induktion aus Fortsetzungen solcher einfacher Typen auf eine kompakt modulo Zentrum Untergruppe gewinnen lassen. Um die Vollst{\"a}ndigkeit dieser Konstruktion zu demonstrieren, h{\"a}tten wir allerdings noch die Eigenschaft ``Verkettung impliziert Konjugation'' zu zeigen, welche wir ebenfalls auf eine Folgearbeit verschieben m{\"u}ssen. Beabsichtig w{\"a}re dann ein Vollst{\"a}ndigkeitsbeweis mit dem abstrakten Matchingsatz wie bei L. Corwin \cite{Co} oder in \cite{Z4}. Wir weisen hier nur in Spezialf{\"a}llen nach, dass die Typendarstellungen, welche wir hier angegeben haben, tats{\"a}chlich Typen im Sinne von \cite{BK4}(4.1)(4.2) sind. Insbesondere sind es auch unsere Berechnungen in der Arbeit \cite{GSZ}, welche dem von uns im Geiste von \cite{Z7} und \cite{BK1} gemachten Ans{\"a}tzen hohe Evidenz geben.<br>In this thesis, we try to explain how simple characters for arbitrary central simple algebras over a non-archimedian local field $F$ can be constructed. Moreover, we introduce a kind of matching of simple characters between different algebras of fixed reduced degree. If the index of the algebra $A$ is odd or $A=M_l(D)$, where $l$ is an arbitrary prime number and $D$ a central division algebra over $F$, we can extend the Heisenberg representations associated to the simple characters to level-0 and obtain a hypothetical list of simple types. For $A=M_l(D)$ and if the residual field of $F$ is not the field with two elements, we can proof that all so-called maximal simple types in our list are simple types in the sense of \cite{BK4} and their extensions to their stabelizers induce supercupidal representations of $G_l(D)$. Using the the heuristical relation via the abstract matching theorem of \cite{BDKV} to the cases of a division algebra due to \cite{Z5} and to the split case due to \cite{BK1}, we conjecture that all supercuspidal representations of $Gl_l(D)$ can be obtained by this way.
42
Pester, M., and S. Rjasanow. "A parallel preconditioned iterative realization of the panel method in 3D." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800562.
Full textAbstract:
The parallel version of precondition iterative techniques is
developed for matrices arising from the panel boundary element
method for three-dimensional simple connected domains with
Dirichlet boundary conditions. Results were obtained on an
nCUBE-2 parallel computer showing that iterative solution methods
are very well suited also in three-dimensional case for
implementation on a MIMD computer and that they are much more
efficient than usual direct solution techniques.
43
Apel, Th. "Interpolation of non-smooth functions on anisotropic finite element meshes." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199801341.
Full textAbstract:
In this paper, several modifications of the quasi-interpolation operator
of Scott and Zhang (Math. Comp. 54(1990)190, 483--493) are discussed.
The modified operators are defined for non-smooth functions and are suited
for the application on anisotropic meshes. The anisotropy of the elements
is reflected in the local stability and approximation error estimates.
As an application, an example is considered where anisotropic finite element
meshes are appropriate, namely the Poisson problem in domains with edges.
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Apel, T., and S. Nicaise. "Elliptic problems in domains with edges: anisotropic regularity and anisotropic finite element meshes." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800553.
Full textAbstract:
This paper is concerned with the anisotropic singular behaviour of the solution of elliptic boundary value problems near edges. The paper deals first with the description of the analytic properties of the solution in newly defined, anisotropically weighted Sobolev spaces. The finite element method with anisotropic, graded meshes and piecewise linear shape functions is then investigated for such problems; the schemes exhibit optimal convergence rates with decreasing mesh size. For the proof, new local interpolation error estimates in anisotropically weighted spaces are derived. Moreover, it is shown that the condition number of the stiffness matrix is not affected by the mesh grading. Finally, a numerical experiment is described, that shows a good agreement of the calculated approximation orders with the theoretically predicted ones.
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Ma, Zheng. "Analyse von Schnittstellenkompatibilität von Steuergeräten auf Basis von MSC-Beschreibungen." Master's thesis, Universitätsbibliothek Chemnitz, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200800289.
Full textAbstract:
In modernen Fahrzeugen befindet sich eine Vielzahl von Steuergeräten, die verschiedenste
Funktionen, wie z.B. das Antiblockiersystem (ABS) realisieren. Die Funktionalitäten
von Steuergeräten werden heute mit unterschiedlichen Methoden beschrieben. Eine
dieser Methoden sind Message Sequence Charts (MSCs). Aufgrund der Freiheitsgrade
von MSCs gibt es verschiedene Möglichkeiten gleiche Funktionalität unterschiedlich zu
beschreiben. In dieser Arbeit wird eine Methode definiert, wie verschiedene MSCs hinsichtlich
Funktionskompatibilität auf Basis von endlichen Automaten untersucht werden
können.
Diese Diplomarbeit ist in zwei Schwerpunkte gegliedert. Zum einen soll ein Konzept
für die Transformation des MSCs in der entsprechenden Automaten-Darstellung und einen
Vergleich-Algorithmus zur Rückwärtskompatibilitätsanalyse der endlichen Automaten entwickelt
werden. Zum anderen ist es Aufgabe, die Methode auf Basis von Java zu implementieren
und in die Software-Plattform CAMP zu integrieren.
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Bourduas, Stephan. "Generation of SDL specifications from UML and MSC use cases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ64058.pdf.
Full text
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Steven, Rory Thomas. "Investigations in MALDI-MSI using a high repetition rate laser." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5392/.
Full textAbstract:
Within these studies the properties of a high repetition rate (≤ 25,000 Hz) Nd:YVO4 laser were investigated with a view to improving the throughput and quality of information obtained from MALDI MS data collected in continuous raster sampling mode. Initially, the nature of the laser beam profile was investigated and a novel fluorometric method developed for imaging these profiles. Analysis of thin film samples of α-cyano-4-hydroxycinnamic acid (CHCA) and lipid standard phophatidylcholine (PC) 34:1 were carried out. Under most conditions a lower repetition rate and slow stage raster speed were found to be optimal. However, in tissue based investigations repetition rates of 5-10 kHz and faster raster speeds were found to increase the detected ion intensity. Subsequent to this, the use of para-nitroaniline (PNA) as an effective matrix for high-repetition rate laser MALDI MSI applications was investigated and compared to CHCA. PNA was found to provide high quality MSI data, comparable to or better than that obtained with CHCA. The utility of CHCA and PNA were then investigated for the repeat analysis of single tissue sections with a view to increasing the amount of information obtained. Up to five analyses of the same tissue section were demonstrated. Repeat analysis was then applied to the acquisition of both lipid and protein data from a single tissue section using multiple matrices and tissue washing.
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Zanin, Daniel Bispo. "Metodologia de análise de whirl flutter utilizando o MSC/NASTRAN." Instituto Tecnológico de Aeronáutica, 2011. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=2990.
Full textAbstract:
O whirl flutter é um fenômeno aeroelástico característico de aeronaves com motores a hélice. Trata-se da instabilidade do movimento de precessão da hélice devido ao acoplamento dos deslocamentos de arfagem e guinada em conjunto com a atuação das forças aerodinâmicas, que alimentam as oscilações do sistema. Inicialmente, o presente trabalho busca entender este mecanismo de flutter através de uma revisão bibliográfica e da obtenção das equações de movimento para um sistema simples com dois graus de liberdade. A seguir, apresenta-se uma metodologia para os cálculos de whirl flutter com o uso do software comercial MSC/NASTRAN. O processo é aplicado ao estudo de caso de uma aeronave bimotora de pequeno porte, utilizando um modelo de elementos finitos para a estrutura de fixação do motor. A introdução dos efeitos giroscópicos e aerodinâmicos da hélice é proporcionada por um pré-processador externo, que também tem o seu funcionamento apresentado. As respostas do NASTRAN para o estudo de caso são então comparadas aos resultados de um programa específico para o cálculo de whirl flutter.
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Redford, Lisa. "Short mononucleotide repeat detection of MSI : towards high throughput diagnosis." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3442.
Full textAbstract:
Microsatellites are short repetitive DNA sequences, which are liable to replication errors. Microsatellite instability (MSI) is controlled by the mismatch repair system, and accumulation of microsatellite mutations is used as a diagnostic criterion for tumours where this repair system is compromised, such as those which develop in Lynch Syndrome (HNPCC) patients. Currently, the Amsterdam II screening criteria and revised Bethesda Guidelines are used to identify tumours for MSI testing using both immunohistochemistry and fragment analysis tests. However, because Lynch Syndrome patients are being missed, testing for all colorectal and endometrial cancers is now being recommended. Faster and cheaper MSI testing methods are therefore desirable. Although PCR and sequencing error compromise sequence based typing of the repeats currently used for diagnosis, some short mononucleotide repeats have been identified which show low level instability, suggesting that sequence typing of short repeats may be possible. Here, I investigate the utility of high throughput sequencing (HTS) as the basis for MSI testing. As an initial assessment of the method, I used the MiSeq platform to type 22 previously published short mononucleotide repeats in 4 microsatellite unstable (MSI-H) tumours, and showed that MSI could be detected above background noise in 7-12bp repeats. To identify the most variable short repeat markers for MSI testing, I then analysed MSI in whole genome sequence data from The Cancer Genome Atlas network, and identified a panel of 120 7-12bp informative mononucleotide repeats which were subsequently evaluated on a panel of 5 MSI-H tumours and controls. The most informative 20 markers were further tested on a panel of 58 colorectal tumours to define thresholds for instability calling. Using a panel of eighteen 8-12bp mononucleotides it was possible to distinguish between MSI-H and microsatellite stable (MSS) tumours with a sensitivity and specificity of 100%. Flanking SNPs were also evaluated and identified an excess of allelic bias among MSI-H tumours compared to MSS tumours, a feature that could be integrated into the MSI test. Finally, short mononucleotide repeats with flanking SNPs were assessed for their potential to identify clonal variation in MSI-H tumours. Using a multiple biopsy approach evidence of different sub-clones was found in three MSI-H tumours, suggesting that these markers could be used for analysis of clonal variation and evolution.
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Yang, Ya-Hui, and 楊雅惠. "The collaborative action research on integration of social studies and msic." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/02157720204262628530.
Full textAbstract:
碩士<br>國立花蓮師範學院<br>國民教育研究所<br>91<br>The proposition of curriculum integration, team teaching, and music sociology has brought a new turning point to the curriculum-integration design about the integration of social studies and music. This approach not only enriches the social studies, but also promotes the learning abilities of both teachers and students in related disciplines. Furthermore, it brings new attempts and hopes to the teaching practices in schools. The study analyzes about the integration of social studies and music. According to Beane’s social integrated concept, Jacobs’ parallel discipline design model, Drake’s multidisciplinary approach, Fogarty’s sequencel model, Barrett’s facets model, Synder’s correlation model, and Berk’s transformative approach, we investigate the model of integrating social studies with music. We adopt the collaborative action research method with the help of social studies teachers and music teachers in the elementary school to observe the feasibility of implementation in the classroom. The results of the study are summarized as follow:
1.The integration of social studies and music can raise
students’ learning motives.
2.The integration of social studies and music can create a
happy atmosphere in class time and increase the students’
learning ability.
3.The integration of social studies and music can facilitate
the communication between parents and children.
4.The team teaching ideal of the integration of social studies
and music needs to be broken through.
5.The integration of social studies and music can change the
thinking model of teachers.
Finally, based on the study, we give some suggestions to the teachers who integrate the social studies and music.