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Azab, Ahmad, and Mahmoud Khasawneh. "MSIC: Malware Spectrogram Image Classification." IEEE Access 8 (2020): 102007–21. http://dx.doi.org/10.1109/access.2020.2999320.
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Wodak, Alex, Ann Symonds, and Ray Richmond. "The Role of Civil Disobedience in Drug Policy Reform: How an Illegal Safer Injection Room Led to a Sanctioned, ‘Medically Supervised Injection Center." Journal of Drug Issues 33, no. 3 (2003): 609–23. http://dx.doi.org/10.1177/002204260303300304.
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In shooting galleries, drug users are able to illegally rent cubicles to inject drugs. Established in Kings Cross, Sydney in the early 1990s, police grudgingly tolerated several such galleries. In 1997, a royal commission recommended that a parliamentary inquiry consider establishing an official medically supervised injecting center (MSIC). Despite strong evidence supporting an MSIC, a majority of the committee voted against a trial facility. As an act of civil disobedience, a group of concerned citizens established an unsanctioned MSIC. However, police soon closed the facility. At a subsequent parliamentary drug summit, delegates voted to support an official trial of an MSIC and invited a congregation of Roman Catholic nuns to establish the facility. When the nuns were instructed to withdraw, the Uniting Church was invited to establish the project. The MSIC opened in May 2001. It can be concluded that public health practitioners wishing to improve appalling outcomes from drug policies sometimes have to resort to civil disobedience in order to achieve their goals.
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Zhang, Guohe, Ye Yuan, Feng Liang, Sufen Wei, and Cheng-Fu Yang. "Low Cost Test Pattern Generation in Scan-Based BIST Schemes." Electronics 8, no. 3 (2019): 314. http://dx.doi.org/10.3390/electronics8030314.
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This paper proposes a low-cost test pattern generator for scan-based built-in self-test (BIST) schemes. Our method generates broadcast-based multiple single input change (BMSIC) vectors to fill more scan chains. The proposed algorithm, BMSIC-TPG, is based on our previous work multiple single-input change (MSIC)-TPG. The broadcast circuit expends MSIC vectors, so that the hardware overhead of the test pattern generation circuit is reduced. Simulation results with ISCAS’89 benchmarks and a comparison with the MSIC-TPG circuit show that the proposed BMSIC-TPG reduces the circuit hardware overhead about 50% with ensuring of low power consumption and high fault coverage.
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Hashim, Norayati, and Mohd Fahmy-Abdullah. "Technical efficiency in the Malaysian electric and electronic manufacturing industry: A stochastic frontier analysis approach." Asian Economic and Financial Review 14, no. 2 (2024): 88–104. http://dx.doi.org/10.55493/5002.v14i2.5008.
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This study measured the level of technical efficiency (TE) that exerted a significant impact on the Malaysian electric and electronic manufacturing industry, which consists of 13 sub-industries, from 2010 to 2015. Unbalanced panel data from 1880 firms was obtained from the Department of Statistics Malaysia. We used stochastic frontier (SFA) analysis with the transcendental logarithmic approach to estimate the empirical analysis parametric. The maximum likelihood estimated regression of the SFA parameters revealed a high total average TE of 0.944%. Both the manufacturing sub-industries for communications equipment (MSIC 263) and irradiation, electromedical, and electrotherapeutic equipment (MSIC 266) demonstrated the highest average TE value and consistency (0.989%). The consumer electronics manufacturing sub-industry (MSIC 264) yielded a notably lower TE level (0.846%). Changes in TE for all industries were monitored via standard deviation analysis. The low standard deviation (SD) for MSIC 263, 271, and 275 indicated continuous progress and demands for these industries, while the higher SD for MSIC 264, 266, 272, and 273 pointed out major changes that happened within the period. The findings demonstrated that studies on the TE levels indicate that the E&E manufacturing industry has highly expended and continuous efforts to update technologies and human capital innovations. Therefore, the practical implication is to achieve Sustainable Development Goal 9 for sustainable industrialization and fostering innovation by 2030.
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G .D, Prasuna, and K. V. Rajendra Prasad. "Implementation of MSIC-TPG in BIST Scheme." IOSR journal of VLSI and Signal Processing 4, no. 3 (2014): 22–29. http://dx.doi.org/10.9790/4200-04332229.
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Prontenko, K. V., V. Ya Andreychuk, V. B. Klimovich, et al. "The effectiveness of sportsmen‟ training in the kettlebell long cycle at the present stage." Scientific Journal of National Pedagogical Dragomanov University Series 15 Scientific and pedagogical problems of physical culture (physical culture and sports), no. 8(128) (December 28, 2020): 159–63. http://dx.doi.org/10.31392/npu-nc.series15.2020.8(128).34.
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The effectiveness of sportsmen‟ training in the kettlebell long cycle is an urgent problem in kettlebell lifting. Trainers and scientists in many countries are looking for ways to improve the system of training in the kettlebell long cycle, as the system of training in kettlebell biathlon is quite effective, and there are still many unresolved issues in training system in kettlebell long cycle.
 The article is devoted to the study of the current state of system of training in the kettlebell long cycle. The dynamics of the implementation of the standards of Master of Sports (MS) and Master of Sports of International Class (MSIC) in the kettlebell long cycle for the period from 2016 to 2019 has been analyzed. The study involved male kettlebell lifters (aged 18-40) of national teams of regions of Ukraine of different weight categories: up to 63 kg, up to 68 kg, up to 73 kg, up to 78 kg, up to 85 kg, up to 95 kg, over 95 kg. The protocols of all-Ukrainian and International kettlebell lifting competitions in the long cycle were analyzed. Research methods: theoretical analysis and generalization of scientific and methodical literature, documentary method (study of competition protocols), methods of mathematical statistics.
 It was found that the number of athletes who fulfilled the standards of MS and MSIC at first in 2019 (MS – 4 people, MSIC – 1 person) is significantly less than in 2016 (MS – 7 people, MSIC – 3 people) by 42.9% (MS) and 33.3% (MSIC). It testifies to the insufficient efficiency of the training system of athletes in the kettlebell long cycle at the present stage and the need for its improvement.
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van Beek, Ingrid. "The Sydney Medically Supervised Injecting Centre: A Clinical Model." Journal of Drug Issues 33, no. 3 (2003): 625–38. http://dx.doi.org/10.1177/002204260303300305.
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The Sydney Medically Supervised Injecting Centre (MSIC) is the first supervised injecting facility (SIF) in Australia and the English-speaking world. It commenced operations in May 2001 as a trial to be independently evaluated. The MSIC was to be the only SIF in Sydney's Kings Cross, a “red-light” area where the drug-using population had previously injected in public or in illegal “shooting galleries” that had proliferated in nearby commercial sex premises since 1990. The aim of the MSIC is to reduce the public health and public order issues arising from unsupervised and public injecting at a local community level. A clinical service model was developed, which would maximize the number of injecting episodes accommodated in a professionally supervised setting and integrate with the other harm reduction services nearby. In its first two years of operation 4,719 registered IDUs made 88,324 visits to inject at the MSIC. There were 553 drug overdoses (81% heroin) managed on site, with no fatalities. Among 1,852 client referrals made for further assistance, 44% were for the treatment of drug dependence. This early experience suggests that the MSIC's clinical model has been acceptable to a significant number of the street-based drug injecting population in this setting.
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M. Salmon, Allison, Vendula Belackova, Ricardo Starling Schwanz, Marianne Jauncey, Sarah Hiley, and Apo Demirkol. "Homelessness among clients of Sydney’s supervised injecting facility." Drugs and Alcohol Today 17, no. 4 (2017): 258–68. http://dx.doi.org/10.1108/dat-06-2017-0026.
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Purpose The Uniting Medically Supervised Injecting Centre (MSIC) opened in Sydney, Australia, in May 2001. Homelessness among people who inject drugs (PWID) in Australia has been increasing, and establishing how supervised injecting facilities (SIFs) might best support clients into housing is an important goal. The purpose of this paper is to update knowledge regarding the accommodation status of MSIC clients, thereby supporting a better understanding of the complex needs of these clients. Design/methodology/approach Client accommodation status at MSIC registration (first visit) and in a brief survey (conducted in May 2016) were compared; unstable accommodation was defined as rough sleeping, couch surfing, hostel, boarding house or crisis accommodation. The bivariate logistic regression analysis was used to explore the association between socio-demographics and accommodation status at both time points; a paired t-test was used to compare the visit records for those who reported stable and unstable accommodation in May 2016. Findings Of 232 clients who were present at MSIC during the week the Brief Survey was conducted, 107 participated. Most were male (79 per cent) with a mean age of 41.4 years. A total of 64 (60 per cent) identified as living in unstable accommodation; having increased from 40 per cent at the time of registration (first visit). There were significant positive associations between unstable accommodation status and unemployment, imprisonment and history of overdose, all measured at registration. In May 2016, unstable accommodation status was significantly associated with age of first injection and with unemployment status (as measured at registration); those living in unstable accommodation in May 2016 had a lower number of visits, a lower number of referrals to health and social services and a lower number of overdoses at MSIC than those living in a stable accommodation. Originality/value The rates of unstable accommodation among MSIC clients have been increasing. These findings highlight the importance of SIFs and drug consumption rooms as venue to address the essential needs of PWID, such as housing. The window of opportunity to support PWID who experience housing instability seems to be narrower than for those who live in stable accommodation.
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Wu, Junhua, Dandan Lin, Guangshun Li, Yuncui Liu, and Yanmin Yin. "Distributed Link Scheduling Algorithm Based on Successive Interference Cancellation in MIMO Wireless Networks." Wireless Communications and Mobile Computing 2019 (June 19, 2019): 1–12. http://dx.doi.org/10.1155/2019/9083282.
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The performance of multiple input multiple output (MIMO) wireless networks is limited mainly by concurrent interference among sensor nodes. Effective link scheduling algorithms with the technology of successive interference cancellation (SIC) can maximize throughput in MIMO wireless networks. Most previous works on link scheduling in MIMO wireless networks did not consider SIC. In this paper, we propose a MIMO-SIC (MSIC) algorithm under the SINR model. First, a mathematical framework is established for the cross-layer optimization of routing and scheduling, with constraints of traffic balance and link capacity. Second, the interference regions are divided to characterize the level of interference between links. Finally, we propose a distributed link scheduling algorithm based on MSIC to eliminate the interference between competing links in the MIMO network. Experimental results show that the MSIC algorithm can increase the end-to-end throughput per unit by approximately 73% on average compared with non-SIC algorithms.
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Wei, Na, Shuni He, Kunming Lu, Jiancang Xie, and Yuxin Peng. "Multi-Stakeholder Coordinated Operation of Reservoir Considering Irrigation and Ecology." Water 14, no. 12 (2022): 1970. http://dx.doi.org/10.3390/w14121970.
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In traditional ecological operation, it is difficult to coordinate the balance among the interests of stakeholders, and stakeholders find it difficult to accept the operation scheme. To address these problems, this study proposed a method of multi-stakeholder coordinated operation of reservoir (MSCOR). By comprehensively considering the interest demands of stakeholders, the multi-stakeholder interval coordination mechanism (MSICM) for reservoir operation was established. The multi-stakeholder coordinated operation model (MSCOM) was constructed. The multi-stakeholder solution algorithm based on the MSICM, the non-dominated sorting genetic algorithm II, and the approach of successive elimination of alternative schemes based on the k-order and p-degree of efficiency (MSIC-NSGA-II-SEABODE) were applied to solve the MSCOR problem. The coordination mechanism, model construction, multi-stakeholder optimization, and multi-attribute decision making were coupled to establish a multi-stakeholder coordinated operation method, comprising the whole process of mechanism–modeling–optimization–decision making. Taking Baojixia Reservoir as an example, the performance of the coordinated operation method was compared with that of the traditional optimal operation method, and the relationship between the irrigation benefits and ecological benefits of the reservoir was explored. The results show that: (1) On the premise of the same satisfaction degree of basic irrigation interests, the ecological AAPFD value of coordinated operation decreased by 0.184, 0.469, and 0.886 in a normal year, dry year, and extraordinary dry year, respectively. The effect of coordinated operation on balancing various stakeholders was more obvious with the decrease in water inflow. (2) The MSICM ensures that the multi-stakeholder operation of the reservoir conforms to the principles of comprehensiveness, balance, and sustainability. (3) The coordination scheme obtained by the MSIC-NSGA-II-SEABODE algorithm is more reasonable and feasible. The research results provide a new idea and method to address the MSCOR problem.
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Glazkov, M. N. "Alexander M. Mazuritsky – The heights taken." Scientific and Technical Libraries, no. 9 (September 17, 2023): 123–31. http://dx.doi.org/10.33186/1027-3689-2023-9-123-131.
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The biography of Alexander Mikhailovich Mazuritskiy, a prominent Russian librarian, teacher, manager of library education, is discussed. In 1973, upon the graduation from the Moscow State Institute of Culture (MSIC), Mazuritsky took a job at Lenin State Library of the USSR, then he worked as an instructor for the State Republican Juvenile Library. In 1977, he started work at Moscow State Institute of Culture Library, and took the post-graduate program at the Institute. In 1982, A. Mazuritsky defended his candidate’s thesis and became a lecturer. In 1984, he became the associate dean, and in 1993 – the dean of the MSIC Library Department. The author discusses the key research works by A. Mazuritsky on the various aspects of the library history in the WWII period, and analyzes in brief the contents and conceptual conclusions. In 2007, A. Mazuritsky defended his doctoral thesis in pedagogy. The author characterizes the contents and importance of his doctoral paper. He gives credits to Mazuritsky’s effort as a manager of MSIC authority departments. The principles of Mazuritsky’s scholar school are discussed; his followers and students who completed dissertation, are named.
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Satheesh, Nitesh. "Medium-Voltage Silicon Carbide Solution for Rail." Electric and Hybrid Rail Technology 2024 (January 2024): 33–34. http://dx.doi.org/10.12968/s2754-7760(24)70011-5.
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Kimber, Jo, Margaret MacDonald, Ingrid van Beek, et al. "The Sydney Medically Supervised Injecting Centre: Client Characteristics and Predictors of Frequent Attendance during the First 12 Months of Operation." Journal of Drug Issues 33, no. 3 (2003): 639–48. http://dx.doi.org/10.1177/002204260303300306.
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This paper describes characteristics of clients registered in the first 12 months of the Sydney Medically Supervised Injecting Centre's (MSIC) operation, as well as predictors of frequent attendance. The study is based on information collected from clients at their initial registration and subsequent service utilization. Most of the 2,719 clients were male (71%), almost half had previously experienced at least one nonfatal heroin overdose, and one quarter had accessed formal drug treatment in the previous 12 months. Characteristics associated with frequent attendance at the MSIC were reporting previous attendance at the local primary health service for injection drug users (IDU), injecting drugs other than amphetamine, reporting sex work, injecting at least daily, and injecting in a public place in the month before registration.
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FREEMAN, KAREN, CRAIG G. A. JONES, DON J. WEATHERBURN, SCOTT RUTTER, CATHERINE J. SPOONER, and NEIL DONNELLY. "The impact of the Sydney Medically Supervised Injecting Centre (MSIC) on crime." Drug and Alcohol Review 24, no. 2 (2005): 173–84. http://dx.doi.org/10.1080/09595230500167460.
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Nash, Chris. "Reporting controversy in health policy: A content and field analysis." Pacific Journalism Review : Te Koakoa 15, no. 2 (2009): 35–53. http://dx.doi.org/10.24135/pjr.v15i2.983.
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This article reports on the research and analysis of editorial attitudes and news reporting in two prominent Sydney newspapers—The Daily Telegraph (DT) and The Sydney Morning Herald (SMH)—about the establishment and operation of the Medically Supervised Injecting Room (MSIC) in Kings Cross from January 1999 to December 2006. The establishment of the MSIC was highly controversial and generated strongly partisan attitudes among politicians, experts, local businesses and the general community. The research compares the editorial stance of these newspapers towards the injecting room and the reporting practices of the newspapers, in particular the range of sources used by the journalists; it deploys a content analysis to identify positive and negative attitudes in the preferred readings of the texts, the usage of sources within the reports and the partisan affiliations of those sources. It reveals stark differences in the reporting of the controversy by the two newspapers, and that the reporting differences were aligned with the respective editorial policies of the mastheads. The interpretation of these empirical findings using field theory is located within the debates in the journalism studies literature about the power relationship of journalistic practices to the interests of sources.
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Mykhaliuk, Yevhen, and Yehor Horokhovskyi. "Effect of the training process of high-class and elite sprint swimmers of both genders on the state of the autonomic nervous system, central hemodynamics and physical working capacity." Physical rehabilitation and recreational health technologies 7, no. 4 (2022): 163–70. http://dx.doi.org/10.15391/prrht.2022-7(4).27.
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Purpose: to investigate the influence of the training process of high-class and elite sprint swimmers of both genders on the parameters of the autonomic nervous system, central hemodynamics and physical working capacity. Material & Methods: in the preparatory period of the training process, 145 sprint swimmers (56 females and 89 males) with sports qualifications from CMS (high-class swimmers) to MS-MSIC (elite swimmers) were examined, of which 56 sprint swimmers (31 females and 25 males) in 2006 and 89 sprint swimmers in 2021 (25 females and 64 males). To assess the autonomic regulation of cardiac activity time- and frequency domain methods of HRV analysis were used. Central hemodynamic parameters were examined by an automated tetrapolar rheography. Physical working capacity was measured according to a common technique on a cycling ergometer using a submaximal PWC170 test and calculating the relative value of physical working capacity, i.e. PWC170/kg. Results: comparison of the studied parameters in sprint swimmers examined in 2006 and 2021 showed a significant decrease in PWC170/kg in present-day high-class sprint swimmers with sports qualification CMS (both females and males), by 23.84%, (p=0.0003) and 12.68% (p=0.018), respectively, and in elite male swimmers with sports qualifications MS-MSIC by 9.46% (p=0.017), as well as a downward trend in elite female swimmers with sports qualifications MS-MSIC by 18.28% (p=0.154). Differences in HRV and central hemodynamics parameters were statistically insignificant. Conclusions: in present-day high-class female swimmers, the predominance of the sympathetic arm of the ANS was revealed, the value of PWC170/kg was 23.84% (p=0.0003) lower than in female swimmers of the same level in 2006. There were no significant differences between all the studied indices of elite female swimmers in 2021 and the indices of female swimmers of the same level in 2006. In present-day elite male swimmers and high-class male swimmers, the value of PWC170/kg was lower, respectively, by 9.46% (p=0.017) and 12.68% (p=0.018) than in swimmers of the same level in 2006. A significant decrease in the functional state of modern swimmers-sprinters of both genders against an earlier achievement of qualification standards than their peers in 2006 may be due to a change in the modern methodology of the training process aimed at reducing the training load in the zone of development of general endurance (aerobic orientation) by increasing the load of speed and power (anaerobic) orientation.
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Sun, Hongda, Hongzhan Lin, and Rui Yan. "Collaborative Synthesis of Patient Records through Multi-Visit Health State Inference." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 17 (2024): 19044–52. http://dx.doi.org/10.1609/aaai.v38i17.29871.
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Electronic health records (EHRs) have become the foundation of machine learning applications in healthcare, while the utility of real patient records is often limited by privacy and security concerns. Synthetic EHR generation provides an additional perspective to compensate for this limitation. Most existing methods synthesize new records based on real EHR data, without consideration of different types of events in EHR data, which cannot control the event combinations in line with medical common sense. In this paper, we propose MSIC, a Multi-visit health Status Inference model for Collaborative EHR synthesis to address these limitations. First, we formulate the synthetic EHR generation process as a probabilistic graphical model and tightly connect different types of events by modeling the latent health states. Then, we derive a health state inference method tailored for the multi-visit scenario to effectively utilize previous records to synthesize current and future records. Furthermore, we propose to generate medical reports to add textual descriptions for each medical event, providing broader applications for synthesized EHR data. For generating different paragraphs in each visit, we incorporate a multi-generator deliberation framework to collaborate the message passing of multiple generators and employ a two-phase decoding strategy to generate high-quality reports. Our extensive experiments on the widely used benchmarks, MIMIC-III and MIMIC-IV, demonstrate that MSIC advances state-of-the-art results on the quality of synthetic data while maintaining low privacy risks.
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Gilson, Ronald J., and Reinier Kraakman. "Investment Companies as Guardian Shareholders: The Place of the MSIC in the Corporate Governance Debate." Stanford Law Review 45, no. 4 (1993): 985. http://dx.doi.org/10.2307/1229201.
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Yang, Dong-Hoon, Shinae Maeng, and Yong-Sun Bahn. "Msi1-Like (MSIL) Proteins in Fungi." Mycobiology 41, no. 1 (2013): 1–12. http://dx.doi.org/10.5941/myco.2013.41.1.1.
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Jamaludin, Mariam, and Zeenat Begam Yusof. "Challenges Faced by MSICs Operators." Asian Journal of Behavioural Studies 2, no. 5 (2017): 1. http://dx.doi.org/10.21834/ajbes.v2i5.44.
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Sustainability becomes main management issues for hospitality firms. Big hospitality firms conduct countless attempts to accommodate into the sustainability agenda. However, the small hospitality firms are left behind. The reason is some challenges that are dragging them. Challenges studies regarding big hospitality companies are plenteous. However, studies regarding challenges of MSIC operators are limited in Malaysia. Therefore, the objectives are to identify the challenges and the rankings. This study is applying the quantitative and qualitative approach. The finding shows that lack of green products is the most salient challenges. In conclusion, this study has managed to identify challenges and provide some recommendations.2398-4295 © 2017 The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK.. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, UniversitiTeknologi MARA, Malaysia.Keywords: Challenges; Green Practices; Relative Importance Index; Micro and Small Island Chalet
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Wang, Qiwei, Weili Zhao, He Huang, and Pengxu Qian. "Transient Activation of PIEZO1 Mechanosensitive Channel Facilitates Ex Vivo expansion of Hematopoietic Stem Cells." Blood 144, Supplement 1 (2024): 2649. https://doi.org/10.1182/blood-2024-193734.
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Achieving long-term ex vivo expansion of functional hematopoietic stem cells (HSCs) is critical for unlocking the potential of clinical applications based on HSC transplantation. Understanding the microenvironment in which HSCs maintain their functions is a prerequisite, with mechanical perception being one of the key factors. Studies have revealed mechanosensitive ion channels (MSICs) are vital in hematopoietic system, but their roles in the expansion and functional maintenance of ex vivo cultured HSCs remain largely elusive. Here, we show that PIEZO1 is the MSIC predominantly expressed in HSCs. Unexpectedly, both absence and sustained chemical activation of PIEZO1 are detrimental to cultured HSCs, suggesting that maintaining cultured HSCs required transient PIEZO1 activation. To identify conditions that lead to such activation, we screen different microspheres and demonstrate that stiff polymer microspheres with a diameter of 500 nm transiently activate PIEZO1. PS500 (polystyrene microsphere with diameter of 500 nm) markedly promotes ex vivo expansion of murine bone marrow (BM)-derived HSCs with long-term in vivo repopulating ability, and also showed expansion effect for human umbilical cord blood (hUCB)-derived HSCs with repopulating ability in primary immunodeficient mice. Mechanistically, the transiently-activated PIEZO1 channels trigger Ca2+-dependent transcription of proliferative cytokines, which ultimately lead to STAT3 activation to maintain self-renewal and promote cell proliferation and survival. Collectively, our results demonstrate that PS500 transiently activates PIEZO1 mechano-sensitive channel and efficiently expands functional HSCs without any toxicity, pointing towards a promising strategy to produce functional HSCs for clinical applications.
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Costelloe, L., K. O'Rourke, C. McGuigan, C. Walsh, N. Tubridy, and M. Hutchinson. "The longitudinal relationship between the patient-reported Multiple Sclerosis Impact Scale and the clinician-assessed Multiple Sclerosis Functional Composite." Multiple Sclerosis Journal 14, no. 2 (2007): 255–58. http://dx.doi.org/10.1177/1352458507081274.
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Background To examine the longitudinal relationship between the patient-rated Multiple Sclerosis Impact Scale (MSIS-29) and the doctor-reported Multiple Sclerosis Functional Composite (MSFC). Methods Two-hundred and four MS patients at baseline and 150 patients one to three years later had MSFC and MSIS-29 assessments. Cross-sectional correlations between these measures and correlations of change in scores were examined. Minimally important change (MIC) in the MSFC was defined at either 0.5 or 0.32 SD from baseline. Effect sizes (ES) were calculated. Results Validity: The MSIS-29 physical correlated moderately with the total MSFC score and the 25-foot timed walk and 9-hole peg test. Correlations of the MSIS-29 physical with the PASAT, and the MSFC with the MSIS-29 psychological were weak. Responsiveness: When MIC in the MSFC was defined as 0.5, mean MSIS-29 physical change was 11.26 (ES = 0.53). At MSFC change of 0.32, mean MSIS-29 physical change was 10.4 (ES = 0.52). Change in MSFC scores correlated weakly with change in the MSIS-29 scores. Stability: In patients with stable MSFC scores, the mean MSIS-29 physical scores improved minimally over time with negligible ES. Conclusions Although the MSIS-29 physical demonstrates moderate cross-sectional correlation with the MSFC, the weak correlations of change scores between the two instruments indicate that they measure different aspects of the effects of multiple sclerosis morbidity. Multiple Sclerosis 2008; 14: 255—258. http://msj.sagepub.com
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Sun, Jixiang, Cheng Tang, Ke Mu, Yanfang Li, Xiangyang Zheng, and Tao Zou. "Tidal Flat Extraction and Analysis in China Based on Multi-Source Remote Sensing Image Collection and MSIC-OA Algorithm." Remote Sensing 16, no. 19 (2024): 3607. http://dx.doi.org/10.3390/rs16193607.
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Tidal flats, a critical part of coastal wetlands, offer unique ecosystem services and functions. However, in China, these areas are under significant threat from industrialization, urbanization, aquaculture expansion, and coastline reconstruction. There is an urgent need for macroscopic, accurate and periodic tidal flat resource data to support the scientific management and development of coastal resources. At present, the lack of macroscopic, accurate and periodic high-resolution tidal flat maps in China greatly limits the spatio-temporal analysis of the dynamic changes of tidal flats in China, and is insufficient to support practical management efforts. In this study, we used the Google Earth Engine (GEE) platform to construct multi-source intensive time series remote sensing image collection from Sentinel-2 (MSI), Landsat 8 (OLI) and Landsat 9 (OLI-2) images, and then automated the execution of improved MSIC-OA (Maximum Spectral Index Composite and Otsu Algorithm) to process the collection, and then extracted and analyzed the tidal flat data of China in 2018 and 2023. The results are as follows: (1) the overall classification accuracy of the tidal flat in 2023 is 95.19%, with an F1 score of 0.92. In 2018, these values are 92.77% and 0.88, respectively. (2) The total tidal flat area in 2018 and 2023 is 8300.34 km2 and 8151.54 km2, respectively, showing a decrease of 148.80 km2. (3) In 2023, estuarine and bay tidal flats account for 54.88% of the total area, with most tidal flats distribute near river inlets and bays. (4) In 2023, the total length of the coastline adjacent to the tidal flat is 10,196.17 km, of which the artificial shoreline accounts for 67.06%. The development degree of the tidal flat is 2.04, indicating that the majority of tidal flats have been developed and utilized. The results can provide a valuable data reference for the protection and scientific planning of tidal flat resources in China.
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McLaughlin, E. A., B. A. Fraser, V. Pye, M. Bigland, N. A. Siddall, and G. R. Hime. "167. MUSASHI FAMILY OF RNA BINDING PROTEINS: CELL CYCLE REGULATORS IN SPERMATOGENESIS." Reproduction, Fertility and Development 22, no. 9 (2010): 85. http://dx.doi.org/10.1071/srb10abs167.
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Mammalian meiosis is a tightly regulated process involving specialized cell cycle progression and morphogenetic changes. We have demonstrated that the Musashi family of RNA binding proteins is implicated in the regulation of spermatogonial stem self renewal and germ cell differentiation. Here we describe the novel mechanism by which the Musashi family proteins, Msi1 and Msi2, act to control exit from spermatogonial mitotic amplification and normal entry into meiosis. Gene and protein analysis indicated overlapping Msi1 and Msi2 profiles in enriched populations of isolated germ cells and reciprocal subcellular expression patterns in spermatogonia and pachytene spermatocytes/ round spermatids in testes sections. Recombinant Msi1 protein-RNA pulldown and microarray analysis coupled with in vitro shRNA knockdown studies in spermatogonial culture and subsequent immunoprecipitation and qPCR established that Msi1 targeted Msi2 mRNA for post transcriptional translational repression. Immunoprecipitation of Msi2 target mRNA and subsequent qPCR together with in vitro shRNA knockdown studies inround spermatidculture identified a cell cycle inhibitor protein CDKN1C (p57kip2) as the principal target of Msi2 translational inhibition. Immunolocalisation of CDKN1C protein indicated that expression of this cell cycle regulator coincided with the nuclear import of Msi1 and the appearance of cytoplasmic Msi2 expression in early pachytene spermatocytes. Using a transgenic Msi1 overexpression mouse model in conjunction with quantitative gene and protein expression, we confirmed Msi1 targeting of Msi2 and subsequent Msi2 targeting of CDKN1C for translational repression in vivo. Ectopic overexpression of Msi1 in germ cellsinduces substantial Msi2 downregulation and aberrant CDKN1C expression, resulting in abnormal spermatogenic differentiation, germ cell apoptosis/arrest and sterility. In conclusion, our results indicate a sophisticated molecular switch encompassing cell cycle protein regulation by Musashi family proteins, is required for normal exit from mitotic division, entry into meiosis and post meiotic germ cell differentiation.
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G., Sathesh Kumar*1 &. V. Saminadan2. "A NOVAL BISR APPROACH FOR EMBEDDED MEMORY SELF REPAIR." GLOBAL JOURNAL OF ENGINEERING SCIENCE AND RESEARCHES 5, no. 9 (2018): 267–74. https://doi.org/10.5281/zenodo.1441095.
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As the density of embedded memory increases, manufacturing yields of integrated circuits can reach unacceptable limits. Normal memory testing operations require BIST to effectively deal with problems such as limited access and "at speed" testing. Built-in self-repair (BISR) techniques are widely used for the repair of embedded memories. One of the key components of a BISR circuit is the built-in redundancy-analysis (BIRA) module, which allocates redundancies according to the designed redundancy analysis algorithm. This project proposes a BIRA scheme for RAMs, which can provide the optimal repair rate using very low area cost and single test run of multiple single input change (MSIC) vectors in a pattern. Furthermore, the manifested errors are detected at the modules’ outputs using novel voting, while the latent faults are detected by comparing the internal states of the memory modules. Upon detection of any mismatch, the faulty modules are located and the state of a fault-free module is copied into the faulty modules.
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Hoogervorst, E. LJ, J. NP Zwemmer, B. Jelles, C. H. Polman, and B. MJ Uitdehaag. "Multiple Sclerosis Impact Scale (MSIS-29): relation to established measures of impairment and disability." Multiple Sclerosis Journal 10, no. 5 (2004): 569–74. http://dx.doi.org/10.1191/1352458504ms1078oa.
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Objective: To validate the newly developed Multiple Sclerosis Impact Scale (MSIS-29) in a large, well characterized, independent group of MS patients by investigating the relation between the MSIS-29 and the Guy’s Neurological Disability Scale (GNDS), the Expanded Disability Status Scale (EDSS) and the MS Functional Composite (MSFC). Methods: Two hundred MS patients were recruited at our outpatient department. At the same visit GNDS, EDSS, MSFC and MSIS-29 were assessed. Data obtained from GNDS, EDSS and MSFC assessment were compared to both physical and psychological impact scores of the MSIS-29. In addition the contribution of GNDS subcategories, EDSS functional systems and MSFC components to the physical and psychological impact scores of the MSIS-29 was studied. Results: Median scores were 37.5 for the physical and 22.2 for the psychological impact score of the MSIS-29, 13.0 for GNDS and 4.0 for EDSS. Mean MSFC was 0.07. The physical impact score showed good correlations with both GNDS (0.79) and EDSS (0.68) and a moderate correlation with the MSFC (- 0.53). The psychological impact score showed weak correlations with EDSS (0.22) and MSFC (-0.30) and a moderately strong correlation with the GNDS (0.58). In 50 (25%) patients, scores on physical and psychological impact scales diverted, i.e., a relative high score on one scale combined with a relative low score on the other scale. This was related to the clinical disease course. Conclusion: Our study supports the use of the MSIS-29 as a measure for the assessment of physical impact of MS on normal daily life. In addition, our data provides a deeper understanding of the factors that determine both physical and psychological disease impact. Discrepancies between the latter two aspects deserve further attention.
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Jamaludin, Mariam, and Zeenat Begam Yusof. "Barriers of Adopting Environmental Management Practices in the Micro and Small Island Chalets Operation." Environment-Behaviour Proceedings Journal 1, no. 1 (2016): 171. http://dx.doi.org/10.21834/e-bpj.v1i1.213.
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Sustainability becomes main management issues for hospitality firms. Big hospitality firms conduct countless attempts to accommodate into the sustainability agenda. However, the small hospitality firms are left behind. The reason is some barriers that are dragging them. Barriers studies regarding big hospitality companies are plenteous. However, studies regarding barriers of MSIC operators are limited in Malaysia. Therefore, the objectives are to identify the barriers and the ranking of the barriers. This study is applying the quantitative and qualitative approach. The finding shows that lack of green products is the most salient barrier. In conclusion, this study has managed to identify barriers and provide some recommendations.© 2016. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies, Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: Barriers; green practices; relative importance index; micro and small island chalet
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Ovchinnikov, E. O., L. N. Rogaleva, and B. A. Volpert. "A look at self-realization from the perspective of high-level cycling athletes." Current Issues of Sports Psychology and Pedagogy 4, no. 2 (2024): 45–56. http://dx.doi.org/10.15826/spp.2024.2.106.
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The study of the problem of self-realization in sports involves the analysis of the subjective experience of athletes of a high level of sportsmanship. The purpose of this work was to survey cycling athletes regarding their views on personal self-realization. The sample consisted of 20 athletes with the titles of candidates for Master of Sports (CMS), masters of sports (MS), masters of sports of international class (MSIC) and Honored Masters of Sports. A questionnaire, which includes 22 questions, was developed for the survey. The questionnaire made it possible to identify: 1) the goals and motivation of the racing athletes; 2) satisfaction with the results of their activities; 3) self-assessment of their own capabilities in achieving goals; 4) difficulties arising in the process of sports activities and willingness to overcome them. The results of the study revealed differences in views on cycling athletes, depending on the level of their sports qualifications and individual characteristics of athletes. The obtained data can contribute to the development of strategies for psychological support of elite-level athletes.
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Balkova, I. V. "Living zealously (On Alexander Mazuritsky’s 70<sup>th</sup> anniversary)." Scientific and Technical Libraries, no. 9 (September 17, 2023): 132–40. http://dx.doi.org/10.33186/1027-3689-2023-9-132-140.
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The author gives credits to Alexander Mikhailovich Mazuritsky’s educational efforts. A. Mazuritsky is a prominent library scholar, expert in the library history, Doctor of Science in Pedagogy, Dean of the Library Information Department of Moscow State Institute of Culture (MSIC), Professor of the Information Analytics Chair of Moscow State Linguistic University (MSLU). The author reviews Mazuritsky’s professional and public efforts as a historian, pedagogue and educator in the sphere of higher professional training. His scientific interest toward the problem of missed cultural valuables has transformed into the need to educate historical memory and civic mindedness in the younger generations. In his public lectures and interviews to mass media, speaking at forums and conferences, he strongly promotes libraries engagement in educating ethical principles and social knowledge as the foundation for patriotism. A. M. Mazuritsky maintains his principled stand on the national library policy and library development vectors. Keeping with the best traditions of the Russian library science, Alexander M. Mazuritsky voices challenging ideas and suggestions that stir up disputes and discussions in the professional community.
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Sutherland, Jessie, Alexander Sobinoff, Kara Gunter, et al. "Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis." Biomolecules 5, no. 3 (2015): 1228–44. http://dx.doi.org/10.3390/biom5031228.
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Duggimpudi, S., J. Höll, and A. Borkhardt. "PS1017 MICRO RNA SIGNATURE OF ONCOGENIC MUSASHI RNA BINDING PROTEINS MSI1 AND MSI2." HemaSphere 3, S1 (2019): 458. http://dx.doi.org/10.1097/01.hs9.0000562364.92047.c1.
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Osman, Bulut. "Effects of Intracameral Injection of Phenylephrine - Cyclopentolate and Tropicamide-Lidocaine Hydrochloride Combinations on Ophthalmologic and Cardiovascular Parameters in Healthy Cats." International Journal of Veterinary and Animal Research 5, no. 3 (2022): 129–33. https://doi.org/10.5281/zenodo.7443660.
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In this study, it is aimed to investigate the effects of intracameral mydriatic combinations on the pupil dilation (PD), intraocular pressure (IOP), heart rate (HR) and mean arterial pressure (MAP). In this study 35 animals were divided into 5 groups. The first group (MSic) was phenylephrine hydrochloride (Mydfrin) and cyclopentolate hydrochloride (Sikloplejin), the second group (TLic) was tropicamide (Tropamid) and 2% lidocaine, the third group (BSS) was balanced salt solution. Cats were anesthetized, and all solutions were injected intracamerally. The fourth group (MSt) was phenylephrine hydrochloride (Mydfdrin) and cyclopentolate hydrochloride (Sikloplejin) and the fifth group (TLt) tropicamide (Tropamid) and 2% lidocaine were given by topically. During this research, the fastest onset of the mydriasis was numerically formed by first group. All intracameral groups were seen having longer duration of mydriasis compared to topical groups. Intraocular pressure decreased after anterior camera paracentesis in all intracameral procedures. In our study, time dependent changes of heart rate were found to be statistically significant in all groups. Our research observed that first and second group successfully created enough mydriasis (>10mm). In terms of pupil diameter, it has been proven that first and second group are usable alternatives administration, and no side effects on intraocular pressure, heart rate or mean arterial pressure.
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Nikitina, K., T. Abramova, and T. Nikitina. "MINERAL DENSITY OF BONE TISSUE AND INDICATORS OF BONE REMODELING IN HIGHLY SKILLED ATHLETES IN THE ANNUAL TRAINING CYCLE." Human Sport Medicine 19, no. 4 (2020): 43–49. http://dx.doi.org/10.14529/hsm190406.
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Aim. The article aims at studying the relationship between the mineral density of heel bone and bone remodeling in cyclistduring the annual training cycle. Materials and methods. The study involved 14 highly skilled male cyclists (cycle track, MS, MSIC) aged 20–25 years with a sports experience of 5 to 16 years. The measurements were performed in the preparatory, pre-competitive and competitive periods of the annual training cycle. Bone mineral density (BMD) was measured by the method of quantitative ultrasound densitometry (QUS) using the Achilles Express ultrasonometer (Lunar, USA). BMD was estimated as a percentage of the peak norm for a given section of the skeleton (reference norms for 20–29 years). Results. The dynamics of BMD in the annual cycle correlates with a change in bone remodeling and phosphorus-calcium metabolism. A decrease in BMD during the competitive period is associated with an increase in β-Cross Laps and a decrease in osteocalcin, alkaline phosphatase, ionized calcium and serum phosphorus. Conclusion. A decrease in BMD is associated with an increase in the activity of osteoclasts and a decrease in osteoblastic activity. Indicators of bone remodeling and phosphorus-calcium metabolism reflect the status of bone tissue and the processes of general adaptation to training loads, and can be used as markers of risk of decreased BMD. The heel bone QUS method can be used to identify athletes at risk for hypotrophic conditions.
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Golovachev, A., V. Kolykhmatov, and S. Shirokova. "MODEL INDICATORS OF PHYSICAL PREPAREDNESS OF ELITE FEMALE SKI-RACERS IN PREPARATION FOR THE 2022 WINTER OLYMPIC GAMES IN BEIJING (CHINA)." Human Sport Medicine 19, S2 (2020): 81–87. http://dx.doi.org/10.14529/hsm19s211.
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Aim. The purpose of the article is to develop model characteristics of physical qualities in elite skiers that determine the level of their physical fitness, the achievement of which is able to ensure successful performance at 2022 Winter Olympics in Beijing (China). Materials and methods. The study involved 19 female skiers, specializing in various types of competitive activity, aged from 19 to 27 years, with experience from 6 to 13 years and qualification from CMS to MSIC. The physical fitness of athletes was studied during the 2015–2018 Olympic cycle. using special training devices (strain gauge platform and inertial training machine) as part of the scientific program dedicated to integrated examinations in the laboratory of cyclic Olympic sports (All-Russian Research Institute of Physical Education and Sports). Results. Taking into account the requirements for the model features of athletes during their preparation for the Olympic Games, 9 statistically significant indicators were selected to assess explosive force of the arms and legs, speed and strength endurance of the hands, which determine the general development of physical fitness. Conclusion. The results presented in the article are a logical continuation of a comprehensive study on the formation of a structural-functional model (Olympian-2022 model). This model allows to assess the development of the functional status and leading physical qualities in elite athletes, identify their readiness to perform specialized muscle activity and improve the training process for 2022 Winter Olympics in Beijing (China).
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Kanyhina, S. M., V. V. Syvolap, and M. S. Potapenko. "Endothelial function in athletes in the process of adaptation to training loads of different orientations." Zaporozhye Medical Journal 23, no. 1 (2021): 52–59. http://dx.doi.org/10.14739/2310-1210.2021.1.224881.
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Studies on endothelial dysfunction and its relationship with adaptive disorders in highly skilled athletes are few in number and mainly carried out in cyclic kinds of sports due to larger volumes and higher intensities of training loads associated with endurance performance gain. Stress and sex hormones and growth hormone play an important role in the regulation of endothelial function, but factors, which can stimulate negative vascular changes, remain a matter of debate. It is also unclear, whether changes in the vascular system depend on the type, mode or intensity of physical activity. The aim of the work was to perform a comparative assessment of endothelial function and to study the role of some hormones in its regulation in highly qualified athletes in the process of adaptation to various training loads. Material and methods. After signing a written informed consent, the study involved 104 athletes (80 men and 24 women) qualifying from the First-Class athletes to Masters of Sports of International Class (MSIC): 63 – athletes, who mainly trained endurance performance (triathletes, swimmers, long-distance runners, rowers), 31 – strength performance (weightlifters, powerlifters, kettlebell lifters), 10 – speed performance (sprinters). The mean age of the examined athletes was 21.75 ± 3.32 years. Among them, there were Masters of Sports of International Class (MSIC) – 2 athletes, Masters of Sports (MS) – 25, Candidates Master of Sports (CMS) – 48, First-Class athletes – 29. Plasma levels of endothelin-1, 6-keto-PG, erythropoietin, growth hormone, testosterone, free testosterone were determined by enzyme-linked immunoassay on a Seac ELISA-Reader Sirio S (Seac Radim Company, Italy). Results. There was no statistically significant difference in endothelin-1 levels between the endurance and strength athletes, but the strength-trained athletes showed a tendency towards endothelin-1 level predominance (0.77 ± 0.04 fmol/ml vs. 0.72 ± 0.06 fmol/ml; P = 0.176) and 2 times (P = 0.017) higher levels of 6-keto-PG. The endothelin-1 and 6-keto-PG levels did not differ significantly between the endurance and speed athletes. The strength-trained athletes exhibited 5.2 % (P = 0.016) higher endothelin-1 levels than speed-trained athletes. However, these athletes did not differ statistically in the 6-keto-PG (292.30 ± 70.38 pg/ml against 106.92 ± 74.44 pg/ml; P = 0.834) level. A positive correlation was found between the levels of erythropoietin and 6-keto-PG in the endurance-trained (r = 0.57; P = 0.00001) and strength-trained (r = 0.46; P = 0.013) athletes. Analysis of testosterone and free testosterone levels did not reveal statistically significant differences between endurance-, strength- or speed-trained athletes. At the same time, there was a trend towards higher levels of testosterone and free testosterone in the strength-trained athletes as compared to those in the endurance- or speed-trained athletes. The strength athletes showed a positive correlation (r = 0.46; P = 0.013) between the levels of free testosterone and endothelin-1. The highest level of somatotropic hormone was in the speed-trained athletes (11.74 ± 3.13 mIU/l), 2 times less - in the endurance-trained athletes (5.69 ± 1.19 mIU/l), and the lowest one – in the strength-trained athletes (2.66 ± 1.32 mIU/l). A positive correlation between the growth hormone and erythropoietin levels (r = 0.29; P = 0.038) was revealed in the endurance athletes. Conclusions. The endurance and speed athletes did not differ in the levels of endothelin-1, 6-keto-PG, erythropoietin, and testosterone. The strength-trained athletes showed signs of endothelial dysfunction: higher endothelin-1 levels with significantly reduced growth hormone and a tendency of increase in the serum testosterone level, as well as a compensatory increase in 6-keto-PG to maintain the balance between vasoconstrictors and vasodilators.
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Horisawa, Kenichi, Takao Imai, Hideyuki Okano, and Hiroshi Yanagawa. "The Musashi family RNA-binding proteins in stem cells." BioMolecular Concepts 1, no. 1 (2010): 59–66. http://dx.doi.org/10.1515/bmc.2010.005.
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AbstractThe Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which encode regulators of signal transduction and the cell cycle. Recently, strong expression of Msi1 in various somatic stem/progenitor cells of adult tissues, such as eye, gut, stomach, breast, and hair follicle, has been reported. The protein is also expressed in various cancer cells, and ectopically emerging cells have been found in neural tissues of patients with diseases involving neural disorder, including epilepsy. Many novel target mRNAs and regulatory pathways of Msi1 have been reported in recent years. Here, we present a review of the functions and action mechanisms of Msi1 protein and discuss possible directions for further study.
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Wright, Brian L., Shelly L. Counsell, Ramon B. Goings, Hollee Freeman, and Felicia Peat. "Creating access and opportunity." Journal for Multicultural Education 10, no. 3 (2016): 384–404. http://dx.doi.org/10.1108/jme-01-2016-0003.
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Purpose Research often neglects the full continuum of the STEM pipeline in terms of underserved and underrepresented populations. African American males, in particular, experience limited access, opportunity, and preparation along STEM trajectories preK-12. The purpose of this paper is to challenge this gap by presenting examples of preK-12 programs that nurture and promote STEM development and learner outcomes for underrepresented populations. Design/methodology/approach A culturally responsive, asset-based approach emphasizes the importance of leveraging out-of-school practices that shape African-American males learning experiences. From a practitioner standpoint, the need to understand the importance of developing a STEM identity as a conduit to better improve STEM outcomes for African-American males is discussed. Findings To respond to the full continuum of the pipeline, the authors highlight the role of families and STEM programs that support African-American male students’ STEM identity development generally with an emphasis on how particular out-of-school programs (e.g. The Children’s Museum of Memphis [CMOM], MathScience Innovation Center [MSiC]) cultivate STEM trajectories. The authors conclude with how preK-12 settings can collaborate with local museums and other agencies to create opportunities for greater access and improve the quality of African-American males’ STEM preparation. Originality/value The intellectual value of our work lies in the fact that few studies have focused on the importance of examining the full continuum of the STEM pipeline with a particular emphasis on STEM development in early childhood (preK-3). Similarly, few studies have examined the role of identity construction and meaning-making practices as a conduit to better STEM outcomes for African-American males prek-12.
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Lan, Lan, Jiajun Liu, Minli Xing, et al. "Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction." Cancers 12, no. 8 (2020): 2221. http://dx.doi.org/10.3390/cancers12082221.
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RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21WAF-1, key regulators of Notch/Wnt signaling and cell cycle progression, respectively. In this study, we aim to identify small molecule inhibitors of MSI1–mRNA interactions, which could block the growth of cancer cells with high levels of MSI1. Using a fluorescence polarization (FP) assay, we screened small molecules from several chemical libraries for those that disrupt the binding of MSI1 to its consensus RNA. One cluster of hit compounds is the derivatives of secondary metabolites from Aspergillus nidulans. One of the top hits, Aza-9, from this cluster was further validated by surface plasmon resonance and nuclear magnetic resonance spectroscopy, which demonstrated that Aza-9 binds directly to MSI1, and the binding is at the RNA binding pocket. We also show that Aza-9 binds to Musashi-2 (MSI2) as well. To test whether Aza-9 has anti-cancer potential, we used liposomes to facilitate Aza-9 cellular uptake. Aza-9-liposome inhibits proliferation, induces apoptosis and autophagy, and down-regulates Notch and Wnt signaling in colon cancer cell lines. In conclusion, we identified a series of potential lead compounds for inhibiting MSI1/2 function, while establishing a framework for identifying small molecule inhibitors of RNA binding proteins using FP-based screening methodology.
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Mu, Qitian, Yungui Wang, Bing Chen, et al. "High Musashi-2 Expression Is an Unfavorable Prognostic Factor in Adult B-Cell Acute Lymphoblastic Leukemia." Blood 120, no. 21 (2012): 2508. http://dx.doi.org/10.1182/blood.v120.21.2508.2508.
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Abstract Abstract 2508 Background: Musashi-2 (MSI2) can inhibit translation of the mRNA encoding NUMB, the NOTCH signaling inhibitor, and play a vital role in the maintenance of hematopoietic stem cells. Musashi-1 (MSI1), another isoform of Musashi family, positively regulates NOTCH1 expression. Recent studies have demonstrated that MSI2 expression was up-regulated during chronic myelogenous leukemia (CML) progression and its high expression was associated with poor outcome of CML and acute myeloid leukemia (AML). However, the prognostic significance of MSI2 expression and the relation between MSI2 and NOTCH1 expressions in acute lymphoblastic leukemia (ALL) remain unknown. Methods: In this study, real-time PCR was used to measured expression levels of MSI2 and NOTCH1 signaling related genes in 116 B-ALL and 24 T-ALL patients, in whom more than 70% leukemic cells were morphologically detected in bone morrow (BM) at diagnosis. Clinical and Molecular data in relation with MSI2 expression level were analyzed. Results: In our B-ALL cohort, although MSI2 expression was not associated with gender, age, white blood cell (WBC), t(9;22)/BCR-ABL and IK6 variant of IKZF1, patients with high MSI2 expression had inferior overall survival (OS) (P=0.007) and event free survival (EFS) (P=0.002) than patients with low MSI2 expression. Multivariate analysis showed that high MSI2 expression was an independently prognosic factor in OS (P=0.001, HR=2.641, 95%CI, 1.494–4.668), EFS (P<0.001, HR=2.562, 95%CI, 1.513–4.218) and RFS (P=0.043, HR=2.057, 95%CI, 1.023–4.137). Moreover, MSI2 expression level had a positive correlation with that of NOTCH1 (P<0.001), but not c-MYC (P=0.432) or HES1 (P=0.509). Similarly, NOTCH1 expression level in patients with high MSI2 expression (0.98, range 0.02 to 13.58) was significantly higher than that in patients with low MSI2 expression (0.42, range 0.01 to 3.55, P=0.001), but c-MYC and HES1 expression levels between patients with high MSI2 expression and low MSI2 expression showed no significant differences (both P>0.05). Conclusion: Our data suggests MSI2 high expression can indicate poor prognosis in adult B-ALL accompanying with elevated NOTCH1 expression but not activating NOTCH1 downstream pathway. Disclosures: No relevant conflicts of interest to declare.
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Simeonov, Simeon, and G. Michael Schneider. "MSIM." ACM SIGCSE Bulletin 27, no. 2 (1995): 13–17. http://dx.doi.org/10.1145/201998.202003.
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Gorgone, John T., Paul Gray, Edward A. Stohr, Joseph S. Valacich, and Rolf T. Wigand. "MSIS 2006." ACM SIGCSE Bulletin 38, no. 2 (2006): 121–96. http://dx.doi.org/10.1145/1138403.1138448.
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Brom, J. M., A. Lounis, I. Ripp, and A. Zghiche. "Comparative studies of MSGC and MSGC – GEM detectors." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 419, no. 2-3 (1998): 400–404. http://dx.doi.org/10.1016/s0168-9002(98)00814-6.
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Arai, Hiroyuki, Shu Cao, Fotios Loupakis, et al. "Genetic variants in RNA binding protein (RBP) to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3, TRIBE, and MAVERICC trials." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3545. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3545.
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3545 Background: RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by stabilizing or destabilizing target messenger RNA. Although alteration of RBPs affects many steps of cancer development, its clinical implication in mCRC remains unclear. Methods: We analyzed data from mCRC patients (pts) enrolled in three first-line randomized trials (FIRE-3, TRIBE, and MAVERICC). Genomic DNA from blood samples of pts was genotyped through the OncoArray, a custom array manufactured by Illumina. Candidate 30 SNPs in 10 RBP genes (MSI1, MSI2, ELAVL1, RBM3, LIN28A, LIN28B, IGF2BP1, IGF2BP2, IGF2BP3, ZFP36) were tested on association with progression-free survival (PFS) and overall survival (OS). To evaluate prognostic effects and heterogeneities across treatment arms, meta-analysis approach using the METASOFT software was conducted. We also tested interaction between each SNP and treatment within each trial, i.e. FIRE-3 cohort (FOLFIRI+cetuximab (Cet) vs FOLFIRI+bevacizumab (Bev)) and MAVERICC cohort (FOLFIRI+Bev vs FOLFOX6+Bev). For multiple testing, p values were adjusted by the false discovery rate (FDR) method. Results: A total of 884 pts’ SNPs data were available (FIRE-3: n = 236, TRIBE: n = 324, and MAVERICC: n = 324). Meta-analysis combining three trials showed RBM3 rs926152 (adjusted p = 0.045) and RBM3 rs2249585 (adjusted p = 0.016) were significantly prognostic for PFS. Whereas, in terms of OS, only LIN28B rs314277 (adjusted p = 0.045) was significant, and RBM3 rs926152 (adjusted p = 0.057) and RBM3 rs2249585 (adjusted p = 0.059) had a trend. Interaction test showed several SNPs were potentially predictive (raw p < 0.05), although without any significance after FDR adjustment: in FIRE-3 cohort, MSI2 rs1822381, RBM3 rs926152, LIN28B rs221635, IGF2BP1 rs2969 for OS; in MAVERICC cohort, MSI1 rs1179442 and MSI2 rs3826301 for OS, ELAVL1 rs4804244 for PFS. Conclusions: Our results indicate prognostic potential of SNPs in RBP genes, such as RBM3 and LIN28B, in mCRC. However, we find no distinct evidence that these SNPs can predict differential effect between Cet and Bev, or between oxaliplatin- and irinotecan-based chemotherapy.
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Kharas, Michael G., Christopher Lengner, Fatima Al-Shahrour, Benjamin L. Ebert, and George Q. Daley. "Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal." Blood 118, no. 21 (2011): 222. http://dx.doi.org/10.1182/blood.v118.21.222.222.
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Abstract Abstract 222 Genes that regulate normal hematopoietic stem cells are commonly dysregulated in hematopoietic malignancies. Recently we published that the Msi2 RNA binding protein is an important modulator in both normal hematopoietic stem cells and leukemia (Kharas et al, Nat. Medicine 2010). The closely related Msi1 protein has been shown to regulate mRNA translation through binding to the 3'UTR. Based on the high homology in the RNA recognition motifs, Msi2 has been considered to have similar functions. Moreover, increased MSI2 expression in chronic myelogenous leukemia blast crisis and acute myeloid leukemia predicts a worse clinical prognosis. Previous studies have mainly utilized shRNAs to functionally assess the role of Msi2 in the hematopoietic compartment. However, it remains unclear how Msi2 affects hematopoietic stem cells (HSC) and what are its critical mRNA targets. To develop a model focusing on the HSC compartment and to avoid potential compensatory mechanisms during development, we created Msi2 conditional knockout mice and crossed them with Mx1-Cre mice. We induced excision with poly(I):poly(C), (pIpC), and tested the peripheral blood, bone marrow cells and splenocytes by Southern blotting and QPCR analysis to verify Msi2 deletion. Loss of Msi2 mRNA was confirmed in the Lineagelo, Sca1+ and c-Kit+ (LSK) population. Msi2 deleted bone marrow contained reduced myeloid colony forming capacity and replating efficiency. Mice conditionally deleted for Msi2 had normal white blood cell counts but smaller spleens. In addition, we observed normal percentages of the mature hematopoietic populations, including the myeloid and lymphoid compartments. Nevertheless, absolute numbers of long-term HSCs in the bone marrow were reduced by 3-fold. Bone marrow cells non-competitively transplanted into primary and secondary recipient mice showed a dramatic reduction in HSC chimerism. This defect was also observed when bone marrow was transplanted first to allow engraftment followed by Msi2 deletion. Furthermore, we were able to recapitulate this defect in vitro using the cobblestone-forming activity assay. These results indicate that Msi2 is both an important regulator of normal HSC maintenance and required for efficient engraftment. Most interestingly, Msi2 HSCs failed to maintain a normal quiescent HSC population. We performed microarrays to identify the pathways altered in the LSK population. The Msi2 deficient LSKs showed a reduced self-renewal and increased differentiation gene signature. Gene expression analysis indicates a defective self-renewal program in Msi2-deficient HSCs that is identical to the program gained in leukemic stem cells. These data suggest that MSI2 is a critical modulator of HSCs and may help explain its requirement in the most aggressive myeloid leukemias. Disclosures: Daley: iPierian, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Epizyme, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Verastem, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Solasia, KK: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; MPM Capital, Inc: Consultancy, Membership on an entity's Board of Directors or advisory committees; Johnson & Johnson: Membership on an entity's Board of Directors or advisory committees.
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Moffett, Peter, and Jerry Pelletier. "Different transcriptional properties of mSim-1 and mSim-2." FEBS Letters 466, no. 1 (2000): 80–86. http://dx.doi.org/10.1016/s0014-5793(99)01750-0.
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Nadvornikova, Sylvie, Marketa Zackova, Tereza Lopotova, Hana Klamova, and Jana Moravcova. "The Musashi 2 mRNA Expression in the Course of CML." Blood 120, no. 21 (2012): 2552. http://dx.doi.org/10.1182/blood.v120.21.2552.2552.
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Abstract Abstract 2552 The Musashi (MSI) gene family members, MSI1 and MSI2, represent an evolutionarily conserved family of RNA-binding proteins that regulate mRNA translation through binding in their N-termini. High levels of MSI2 protein are associated with increased cell proliferation, decreased cell maturation, more aggressive hematologic malignancy diseases and worse clinical prognosis. Recently obtained data pointed to MSI2 playing an important role in acute myeloid leukemia (AML) and in deadly blast crisis of chronic myeloid leukemia (CML) (Ito et al. 2010 Nature 5; 466). In this study we screened the level of MSI2 mRNA in 49 patients in different phases of CML and with different response to therapy – 18 patients at diagnosis (DG), 5 in major molecular response (MMR), 4 in complete molecular response (CMR), 2 after bone marrow transplantation (BMT), 10 in hematology relaps (HR), 6 in accelerrated phase (AP), and 4 in blast crisis (BC), and in 6 healthy donors. The level of MSI2 mRNA was quantified by real-time reverse-transcriptase-polymerase chain reaction using in-house designed specific primers and TaqMan probe and normalized to B2M endogenous control. Expression ratios were calculated by ΔΔCt method, and the differences between groups were statistically evaluated using Mann Whitney test. We detected MSI2 expression in all samples. The median expression of mRNA MSI2 in patients at DG was 1,43 (0,33–3,28), in MMR 0,52 (0,20–0,62), in CMR 0,37 (0,30–0,63), after BMT 1,28 (1,02–1,54), in HR 0,41 (0,16–0,58), in AP 3,78 (1,94–13,69), in BC 15,17 (2,61–28,15). MSI2 expression was statistically up-regulated in patients in advanced phases of CML (AP, BC) when compared with patients in CP (P<0.0001). The difference between patients in DG and remaining patients in CP was also statistically significant (P= 0,0006). No correlation of MSI2 expression level in DG patients with their responsiveness to treatment, BCR-ABL transcript level or survival was found. No significant differences were observed among groups of patients in MMR, CMR, HR, and after BMT. In addition, in order to check whether MSI2 expression level can serve as a marker of CML progression we also retrospectively screened kinetics of MSI2 transcript in 5 CML patients monitored on average 27 months (18–48). During this period, 3 patients developed HR, 1 patient AP and 1 BC. In BC patient the MSI2 transcript level increased with progression of CML in accordance with the increase of leucocytes and BCR-ABL transcript level. In 1 patient with a rising AP BCR-ABL levels remained constant compared to sevenfold increase of the MSI2 transcript level. On the other hand in HR patients we detected a constant or even decreasing level of MSI2 transcript regardless of the increase of leucocytes and BCR-ABL. In summary, our results confirm the association of high MSI2 mRNA level with advanced phases of CML and indicate that increase of MSI2 mRNA level may serve as a valuable marker of advanced phases of CML. In particular for CML patients with constantly high level of BCR-ABL mRNA the monitoring of MSI2 level can be important tool for early recognition of CML progression. Potential contributions of MSI2 to leukemic pathogenesis and its regulation in CML progression remain unknown. Grant support: NT/12392-4 IGA MZ-CR. Disclosures: No relevant conflicts of interest to declare.
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Malone, Tiffany, John A. Schafer, Lacey Sayre, and Brian Hutchinson. "Outcomes of a Day Wellness Program for People With Multiple Sclerosis Before and During the COVID-19 Pandemic." International Journal of MS Care 26, Q3 (2024): 233–38. http://dx.doi.org/10.7224/1537-2073.2023-018.
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ABSTRACT BACKGROUND: The John A. Schafer, MD Multiple Sclerosis Achievement Center (MSAC) conducts wellness programs that include exercise, cognitive stimulation, education, emotional support, and socialization for people with multiple sclerosis and their care partners. Patient-reported outcomes (PROs) are collected annually. Four-year outcomes encompass the COVID-19 pandemic when some of these programs were offered virtually. METHODS: Beginning in 2017, baseline data were collected for 110 MSAC day wellness program participants through PRO measures. Of those 110, 52 completed PROs annually through 2021. Outcome measures included the Multiple Sclerosis Impact Scale (MSIS-29); Multiple Sclerosis Self-Efficacy Scale (MSSE-10); Godin Leisure-Time Exercise Questionnaire (GLTEQ); and the Neurology Quality of Life domains of Anxiety, Depression, Emotional and Behavioral Dysregulation, Positive Affect, Cognition, Ability to Participate in and Satisfaction with Social Roles and Activities, and Satisfaction with Social Roles and Activities. Analysis using t tests compared baseline with 4-year data. A separate analysis compared outcomes collected in January 2020 and January 2021. RESULTS: Analysis of 4-year data demonstrated statistically significant improvement in MSIS-29 and GLTEQ. Statistically significant improvements noted at years 2 and 3 in the Ability to Participate in Social Roles and Activities were no longer significant at year 4. Other notable changes included significant decreases in MSSE at year 4 when compared with baseline and year 3. CONCLUSIONS: Individuals who participated in a weekly, structured day wellness program showed improvements in self-reported disease impact and physical activity at year 4 vs baseline. Decreases in self-efficacy and social domains were seen, corresponding with disruptions caused by the COVID-19 pandemic. Further analysis is needed to understand the effects of the pandemic on program participants.
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Gorgone, John T. "Approaching MSIS 2000." ACM SIGCSE Bulletin 31, no. 4 (1999): 19–20. http://dx.doi.org/10.1145/349522.349376.
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Danovi, Safia Ali. "Comfortably MSI2–NUMB." Nature Reviews Cancer 10, no. 9 (2010): 602–3. http://dx.doi.org/10.1038/nrc2919.
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Hedin, A. E. "MSIS model (1986)." Planetary and Space Science 40, no. 4 (1992): 555–56. http://dx.doi.org/10.1016/0032-0633(92)90209-7.
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