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Journal articles on the topic 'MSIP'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Wynia, K., AT van Wijlen, B. Middel, SA Reijneveld, and JF Meilof. "Change in disability profile and quality of life in multiple sclerosis patients: a five-year longitudinal study using the Multiple Sclerosis Impact Profile (MSIP)." Multiple Sclerosis Journal 18, no. 5 (2011): 654–61. http://dx.doi.org/10.1177/1352458511423935.

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Background: Evidence on the progress of disease severity in Multiple Sclerosis (MS) is generally limited in scope. Objectives: To examine the course of a broad spectrum of MS-related disabilities and quality of life (QOL) in relation to disease severity, and responsiveness of the Multiple Sclerosis Impact Profile (MSIP). Methods: The mortality rate was calculated after checking the national population register for vital status of the initial cohort. We performed a longitudinal study among 245 patients with MS attending the Groningen MS Center in the Netherlands. We assessed these patients in 2

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2

Tung, Le Thanh. "Strong Karush–Kuhn–Tucker optimality conditions for multiobjective semi-infinite programming via tangential subdifferential." RAIRO - Operations Research 52, no. 4-5 (2018): 1019–41. http://dx.doi.org/10.1051/ro/2018020.

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The main aim of this paper is to study strong Karush–Kuhn–Tucker (KKT) optimality conditions for nonsmooth multiobjective semi-infinite programming (MSIP) problems. By using tangential subdifferential and suitable regularity conditions, we establish some strong necessary optimality conditions for some types of efficient solutions of nonsmooth MSIP problems. In addition to the theoretical results, some examples are provided to illustrate the advantages of our outcomes.

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3

Göçmen, Gökhan, Mehmet Oğuz Borahan, Sertac Aktop, Asım Dumlu, Filiz Namdar Pekiner, and Kamil Göker. "Effect of Septal Deviation, Concha Bullosa and Haller’s Cell on Maxillary Sinus’s Inferior Pneumatization; a Retrospective Study." Open Dentistry Journal 9, no. 1 (2015): 282–86. http://dx.doi.org/10.2174/1874210601509010282.

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Purpose: Maxillary sinus’s inferior pneumatization is a physiological process, which increase with time and accelerates following extraction. The aim of this study was to determine the prevalence of nasal septal deviation (NSD), concha bullosa (CB), and Haller’s cells (HC) and to examine the correlation of maxillary sinus inferior pneumatization (MSIP) with these anatomical variations. Material and Methods : 300 (150 m, 150 f) CBCT scans taken at the Marmara University School of Dentistry from 2011 to 2014 were retrospectively reviewed for the presence of CB, NSD, HC and MSIP. The correlation

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4

Manilla Garcia, A., I. Rivas Cambero, and J. A. Monroy Anieva. "Modelado y Análisis de Sintonización de Velocidad de un MSIP con Presencia de Fisura Mediante Algoritmos Genéticos." Revista Iberoamericana de Automática e Informática industrial 16, no. 2 (2019): 190. http://dx.doi.org/10.4995/riai.2018.9767.

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<p>En el presente artículo se propone el modelado del sistema continuo correspondiente al motor síncrono de imanes permanentes (MSIP) con presencia de degradación en la inercia rotacional del rotor, mediante el mecanismo de fisura, lo cual permite la estimación de parámetros físicos, en el caso de análisis, el diámetro de la grieta presente en el rotor, disminuyendo con ello la incertidumbre en el modelado del MSIP. Se lleva a cabo la identificación en bucle cerrado de las ganancias mediante un análisis de sensibilidad, donde mediante el método computacional de optimización de búsqueda p

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Manilla-García, A., I. Rivas-Cambero, and N. F. Guerrero-Rodriguez. "Propuesta de modelo de variación de consumo de corriente de un MSIP por efecto de desbalance por presencia de grietas superficiales en el rotor." Revista Iberoamericana de Automática e Informática industrial 17, no. 4 (2020): 424. http://dx.doi.org/10.4995/riai.2020.12200.

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<p>En el presente artículo se propone un modelo para caracterizar las variación de corriente en terminales de un motor síncrono de imanes permanentes (MSIP) como consecuencia del efecto de desbalance en el rotor a causa de una grieta superficial. Se modela el desbalance en el rotor mediante las ecuaciones de Laval con acoplamiento del efecto de la grieta superficial. Se propone un modelo de efecto de variación del entrehierro a partir de este desbalance, lo cual origina una variación en las inductancias del modelo del MSIP, que a su vez ocasionan una variación en el consumo de la corrien

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6

Barahona Avalos, Jorge Luis, Rosalino Mayoral Lagunez, José Antonio Juárez Abad, Beatriz Angélica Aguilar López, and Jesús Linares Flores. "Control de velocidad de un motor síncrono de imanes permanentes accionado por un inversor trifásico multinivel." Ingenius, no. 23 (December 27, 2019): 97–108. http://dx.doi.org/10.17163/ings.n23.2020.09.

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Este trabajo presenta el diseño e implementación de un controlador robusto para el seguimiento de velocidad de un motor síncrono de imanes permanentes (MSIP). Se propone un controlador lineal basado en la retroalimentación dinámica de la salida pasiva estática del error exacto. El controlador pasivo propuesto requiere del conocimiento del par de carga, por lo que el mismo es estimado con un observador tradicional de orden reducido. El MSIP es impulsado por medio de un inversor multinivel trifásico de celdas en cascada de cinco niveles. Para la implementación del controlador, estimador y modula

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7

Koh, Seok, and Wook Hyun. "mSIP: Extension of SIP for Soft Handover with Bicasting." IEEE Communications Letters 12, no. 7 (2008): 532–34. http://dx.doi.org/10.1109/lcomm.2008.080335.

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8

Laraqui, A., A. Saaidi, and K. Satori. "MSIP: Multi-scale image pre-processing method applied in image mosaic." Multimedia Tools and Applications 77, no. 6 (2017): 7517–37. http://dx.doi.org/10.1007/s11042-017-4659-0.

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9

Choong-Sik Chung and 진영빈. "Reallocation of public institution related ICT in accordance with launching MSIP." Korean Governance Review 20, no. 3 (2013): 1–25. http://dx.doi.org/10.17089/kgr.2013.20.3.001.

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10

Wynia, K., B. Middel, H. De Ruiter, J. P. Van Dijk, J. H. A. De Keyser, and S. A. Reijneveld. "Stability and relative validity of the Multiple Sclerosis Impact Profile (MSIP)." Disability and Rehabilitation 30, no. 14 (2008): 1027–38. http://dx.doi.org/10.1080/09638280701476193.

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11

von Richthofen, Alexander, Ralph Domnick, and Rainer Cremer. "Cu-N Films grown by reactive MSIP: Constitution, structure and morphology." Microchimica Acta 125, no. 1-4 (1997): 173–77. http://dx.doi.org/10.1007/bf01246182.

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12

AVER’YANOV, D. A. "INNOVATION POTENTIAL MANAGEMENT METHODS OF SMALL AND MEDIUM INNOVATIVE ENTERPRISES." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 2, no. 8 (2020): 48–57. http://dx.doi.org/10.36871/ek.up.p.r.2020.08.02.006.

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Based on the analysis of existing approaches, basic principles and management functions, a methodology for managing the innovative potential of small and medium-sized innovative enterprises has been developed. The activation of MSIP and the management of innovative potential are important scientific tasks, the solution of which will allow the Russian Federation to achieve the necessary rates of economic growth and ensure technological independence.

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13

Lugscheider, E., K. Bobzin, and A. Erdle. "Active soft solder deposition by magnetron-sputter-ion-plating (MSIP)-PVD-process." Thin Solid Films 447-448 (January 2004): 327–31. http://dx.doi.org/10.1016/s0040-6090(03)01110-6.

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14

Lugscheider, E., K. Bobzin, and A. Erdle. "Solder deposition for transient liquid phase (TLP)-bonding by MSIP-PVD-process." Surface and Coatings Technology 174-175 (September 2003): 704–7. http://dx.doi.org/10.1016/s0257-8972(03)00692-3.

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15

Gunda, Naga Siva Kumar, Minashree Singh, Yashasvi Purwar, Sirish L. Shah, Kamaljit Kaur, and Sushanta K. Mitra. "Micro-spot with integrated pillars (MSIP) for detection of dengue virus NS1." Biomedical Microdevices 15, no. 6 (2013): 959–71. http://dx.doi.org/10.1007/s10544-013-9787-3.

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16

Correa-Casas, Juan Diego, Diego Steven Rayo-Villamizar, and Javier Enrique Solano-Martínez. "Representación energética macroscópica y simulación de una máquina síncrona de imanes permanentes." Respuestas 25, no. 3 (2020): 154–64. http://dx.doi.org/10.22463/0122820x.1856.

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Este artículo presenta un modelo de simulación de la máquina síncrona de imanes permanentes (MSIP) y su sistema de control de velocidad utilizando el formalismo de la Representación Energética Macroscópica (REM). Esta descripción gráfica permite realizar un esquema de control basado en la inversión del modelo de la máquina. Los modelos se validan mediante comparación con resultados presentados en la literatura. Para mostrar la utilidad del modelo presentado, se presentan resultados de simulación de la máquina ante diferentes condiciones de operación y referencias de control.

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17

Sarwindah, Sarwindah, Marini Marini, and Tirta Aditya Pratama. "Implementasi MSIP (Manajemen Sistem Informasi Pendistribusian) Keluar Masuk Obat Pada Gudang Farmasi Kelapa." JURNAL MEDIA INFORMATIKA BUDIDARMA 4, no. 2 (2020): 332. http://dx.doi.org/10.30865/mib.v4i2.1952.

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The process of drug distribution is one of the main processes in drug management which has an important role in managing drug availability. In its implementation, the drug distribution process requires information regarding the receipt, supply and expenditure of the drug between the sending and receiving parties, where the information can be changed periodically according to the entry and exit of the drug. Therefore Pharmacy Pharmacy warehouse in Kelapa Puskesmas which has the task of distributing drugs to sub-service units should be able to meet the needs in managing information on the drug d

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18

Bobzin, K., N. Bagcivan, T. Brögelmann, and T. Münstermann. "Development and qualification of a MSIP PVD iridium coating for precision glass moulding." Materialwissenschaft und Werkstofftechnik 44, no. 8 (2013): 673–78. http://dx.doi.org/10.1002/mawe.201300174.

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19

von Richthofen, A., and R. Domnick. "Metastable single-phase polycrystalline aluminium oxynitride films grown by MSIP: constitution and structure." Thin Solid Films 283, no. 1-2 (1996): 37–44. http://dx.doi.org/10.1016/0040-6090(95)08256-5.

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20

McLaughlin, E. A., B. A. Fraser, V. Pye, M. Bigland, N. A. Siddall, and G. R. Hime. "167. MUSASHI FAMILY OF RNA BINDING PROTEINS: CELL CYCLE REGULATORS IN SPERMATOGENESIS." Reproduction, Fertility and Development 22, no. 9 (2010): 85. http://dx.doi.org/10.1071/srb10abs167.

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Mammalian meiosis is a tightly regulated process involving specialized cell cycle progression and morphogenetic changes. We have demonstrated that the Musashi family of RNA binding proteins is implicated in the regulation of spermatogonial stem self renewal and germ cell differentiation. Here we describe the novel mechanism by which the Musashi family proteins, Msi1 and Msi2, act to control exit from spermatogonial mitotic amplification and normal entry into meiosis. Gene and protein analysis indicated overlapping Msi1 and Msi2 profiles in enriched populations of isolated germ cells and recipr

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21

Zhang, Ning, Chun Hong Zhang, and Ying Huai Qiang. "Property Study on High-Speed Steel Deposited TiN Coatings by Magnetron Sputter Ion Plating." Applied Mechanics and Materials 275-277 (January 2013): 1866–69. http://dx.doi.org/10.4028/www.scientific.net/amm.275-277.1866.

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TiN coatings were deposited by Magnetron Sputter Ion Plating (MSIP) on the surface of high-speed steel W18Cr4V.The microstructure,coating thickness, micro-hardness and wear resistance of surface modification sample were investigated by the D/MAX-ⅢB X-ray diffraction tester, the coating thickness tester, the HV-1000 micro-sclerometer,the LKDM－2000 friction and wear tester,the S-3000N scaning electron microscopy.The influence of sputtering time,N2 partial pressures and sputtering current on the microstructure,coating thickness, micro-hardness and wear resistance of TiN coatings were also analyse

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22

Lugscheider, E., S. Bärwulf, and C. Barimani. "Properties of tungsten and vanadium oxides deposited by MSIP–PVD process for self-lubricating applications." Surface and Coatings Technology 120-121 (November 1999): 458–64. http://dx.doi.org/10.1016/s0257-8972(99)00467-3.

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23

von Richthofen, Alexander, Rainer Cremer, and Dieter Neuschütz. "Morphology, structure and constitution of metastable single-phase Ti1-xAlxN films grown by reactive MSIP." Microchimica Acta 125, no. 1-4 (1997): 143–48. http://dx.doi.org/10.1007/bf01246177.

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24

Zhang, Byoung-Tak. "Humans and Machines in the Evolution of AI in Korea." AI Magazine 37, no. 2 (2016): 108–12. http://dx.doi.org/10.1609/aimag.v37i2.2656.

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Artificial intelligence in Korea is currently prospering. The media is regularly reporting AI-enabled products such as smart advisors, personal robots, autonomous cars, and human-level intelligence machines. The IT industry is investing in deep learning and AI to maintain the global competitive edge in their services and products. The Ministry of Science, ICT, and Future Planning (MSIP) has launched new funding programs in AI and cognitive science to implement the government’s newly adopted endeavor of building a “Creative Economy” and “Software Centric Society”. However, AI was not always flo

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25

Yang, Dong-Hoon, Shinae Maeng, and Yong-Sun Bahn. "Msi1-Like (MSIL) Proteins in Fungi." Mycobiology 41, no. 1 (2013): 1–12. http://dx.doi.org/10.5941/myco.2013.41.1.1.

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26

de Waard, Hester. "De Multiple Sclerosis Impact Profile (MSIP): een meetinstrument voor MS-gerelateerde functioneringsproblemen en de beleving daarvan." Nederlands Tijdschrift voor Evidence Based Practice 6, no. 1 (2008): 9–11. http://dx.doi.org/10.1007/bf03077152.

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27

Wynia, Klaske, Berrie Middel, Jitse P. van Dijk, Han de Ruiter, Jacques De Keyser, and Sijmen A. Reijneveld. "The Multiple Sclerosis Impact Profile (MSIP). Development and testing psychometric properties of an ICF-based health measure." Disability and Rehabilitation 30, no. 4 (2008): 261–74. http://dx.doi.org/10.1080/09638280701256868.

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28

Bobzin, Kirsten, Nazlim Bagcivan, and Philipp Immich. "Deposition of Oxides as Tool Protection for Large Thixoforming Dies by Using the Pulsed MSIP-PVD Process." Solid State Phenomena 141-143 (July 2008): 249–54. http://dx.doi.org/10.4028/www.scientific.net/ssp.141-143.249.

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Oxide coatings offer great potential for their use in forming operations in the semi-solid state. Advantages of these types of coatings are high resistance against abrasive wear, high hot hardness and low thermal conductivity. Nevertheless deposition by pulsed Magnetron Sputter Ion Plating-PVD for oxide coatings is quite challenging: deposition rates are low and insulating layers on the target surface can cause arcing. On laboratory scale it was possible to deposit γ-Alumina using PVD in a temperature range, where hot working steel can be utilized. The next important step in the development to

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Wynia, Klaske, Petrie F. Roodbol, and Berry Middel. "Meten van functioneringsproblemen én de beleving ervan bij mensen met Multiple Sclerose: de Multiple Sclerosis Impact Profile (MSIP)." Psychologie en Gezondheid 37, no. 3 (2009): 165–76. http://dx.doi.org/10.1007/bf03080390.

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30

Bobzin, K., N. Bagcivan, M. Ewering, R. H. Brugnara, and S. Theiß. "DC-MSIP/HPPMS (Cr,Al,V)N and (Cr,Al,W)N thin films for high-temperature friction reduction." Surface and Coatings Technology 205, no. 8-9 (2011): 2887–92. http://dx.doi.org/10.1016/j.surfcoat.2010.10.056.

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Bagcivan, N., K. Bobzin, and R. H. Brugnara. "Investigation of the properties of low temperature (Cr1-x Alx )N coatings deposited via hybrid PVD DC-MSIP/HPPMS." Materialwissenschaft und Werkstofftechnik 44, no. 8 (2013): 667–72. http://dx.doi.org/10.1002/mawe.201300173.

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32

Middel, Berry. "Meten van functioneringsproblemen én de gepercipieerde ernst ervan bij mensen met multiple sclerose: de Multiple Sclerosis Impact Profile (MSIP)1)." Nederlands Tijdschrift voor Evidence Based Practice 9, no. 3 (2011): 11–12. http://dx.doi.org/10.1007/s12468-011-0025-9.

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Bobzin, K., N. Bagcivan, M. Ewering, R. H. Brugnara, and T. Münstermann. "Influence of interlayer thickness of a thin noble metal MSIP-PVD coating on compound and system properties for glass lens moulding." Production Engineering 6, no. 3 (2012): 311–18. http://dx.doi.org/10.1007/s11740-012-0385-7.

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34

Horisawa, Kenichi, Takao Imai, Hideyuki Okano, and Hiroshi Yanagawa. "The Musashi family RNA-binding proteins in stem cells." BioMolecular Concepts 1, no. 1 (2010): 59–66. http://dx.doi.org/10.1515/bmc.2010.005.

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AbstractThe Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which encode regulators of signal transduction and the cell cycle. Recently, strong expression of Msi1 in various somatic stem/progenitor cells of adult tissues, such as eye, gut, stomach, breast, and hai

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Lugscheider, E., K. Bobzin, N. Papenfuß-Janzen, M. Maes, and D. Parkot. "Plasma diagnostical comparison of the MSIP process of (Ti,Al)N with pulsed and dc power supplies using energy-resolved mass spectroscopy." Surface and Coatings Technology 188-189 (November 2004): 164–67. http://dx.doi.org/10.1016/j.surfcoat.2004.08.011.

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36

Bošanský, Miroslav, Ernest Gondár, Pavol Švec, František Toth, and Roman Protasov. "A Study of Wear in Thin Coatings Applied to Convex-Concave Gearings." Lubricants 8, no. 5 (2020): 56. http://dx.doi.org/10.3390/lubricants8050056.

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The submitted contribution deals with the wear of thin coatings applied to convex–concave gearings for gear made from C45E steel. The influence of the tribological characteristics (friction coefficient, wear, adhesion and hardness) of the TiN, TiCN coatings and the combined coating of TiCN + MoS2 on convex–concave gearing is described, from the aspects of scuffing formation. Scuffing tests were done on C–C gears. Coatings were applied by arc–ion-plating (AIP) and magnetron sputter-ion-plating (MSIP) methods. The thickness of the deposited coating and its chemical composition were determined by

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37

Wynia, K., B. Middel, JP van Dijk, JHA De Keyser, and SA Reijneveld. "The impact of disabilities on quality of life in people with multiple sclerosis." Multiple Sclerosis Journal 14, no. 7 (2008): 972–80. http://dx.doi.org/10.1177/1352458508091260.

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Objective People with Multiple Sclerosis (MS) experience lower levels of quality of life (QOL) than people from the general population. We examined the relative impact of MS-related disabilities on QOL. Method Data were obtained from a sample of 530 patients who completed the Multiple Sclerosis Impact Profile (MSIP), a disability measure based on the International Classification of Functioning,Disabilities and Health (ICF) and two generic health-related QOL measures, the Medical Outcome study Short Form Questionnaire (SF-36) and the World Health Organization Quality Of Life-BREF (WHOQOL-BREF).

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Wynia, Klaske, and Berry Middel. "De Multiple Sclerosis Impact Profile (msip): een nieuw instrument voor het meten van functioneringsproblemen en de beleving ervan bij mensen met multiple sclerose." Neuropraxis 12, no. 6 (2008): 185–93. http://dx.doi.org/10.1007/bf03077145.

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39

Lan, Lan, Jiajun Liu, Minli Xing, et al. "Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction." Cancers 12, no. 8 (2020): 2221. http://dx.doi.org/10.3390/cancers12082221.

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RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21WAF-1, key regulators of Notch/Wnt signaling and cell cycle progression, respectively. In this study, we aim to identify small molecule inhibitors of MSI1–mRNA interactions, which could block the growth of cancer cells with high levels of MSI1. Using a fluorescence polarization (FP) assay, we screened small molecules from several chemic

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40

Lugscheider, E., O. Knotek, K. Bobzin, and S. Bärwulf. "Tribological properties, phase generation and high temperature phase stability of tungsten- and vanadium-oxides deposited by reactive MSIP-PVD process for innovative lubrication applications." Surface and Coatings Technology 133-134 (November 2000): 362–68. http://dx.doi.org/10.1016/s0257-8972(00)00963-4.

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41

Mu, Qitian, Yungui Wang, Bing Chen, et al. "High Musashi-2 Expression Is an Unfavorable Prognostic Factor in Adult B-Cell Acute Lymphoblastic Leukemia." Blood 120, no. 21 (2012): 2508. http://dx.doi.org/10.1182/blood.v120.21.2508.2508.

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Abstract Abstract 2508 Background: Musashi-2 (MSI2) can inhibit translation of the mRNA encoding NUMB, the NOTCH signaling inhibitor, and play a vital role in the maintenance of hematopoietic stem cells. Musashi-1 (MSI1), another isoform of Musashi family, positively regulates NOTCH1 expression. Recent studies have demonstrated that MSI2 expression was up-regulated during chronic myelogenous leukemia (CML) progression and its high expression was associated with poor outcome of CML and acute myeloid leukemia (AML). However, the prognostic significance of MSI2 expression and the relation between

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42

Annan, Robert B., Cunle Wu, Daniel D. Waller, Malcolm Whiteway, and David Y. Thomas. "Rho5p Is Involved in Mediating the Osmotic Stress Response in Saccharomyces cerevisiae, and Its Activity Is Regulated via Msi1p and Npr1p by Phosphorylation and Ubiquitination." Eukaryotic Cell 7, no. 9 (2008): 1441–49. http://dx.doi.org/10.1128/ec.00120-08.

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ABSTRACT Small GTPases of the Rho family act as molecular switches, and modulation of the GTP-bound state of Rho proteins is a well-characterized means of regulating their signaling activity in vivo. In contrast, the regulation of Rho-type GTPases by posttranslational modifications is poorly understood. Here, we present evidence of the control of the Saccharomyces cerevisiae Rho-type GTPase Rho5p by phosphorylation and ubiquitination. Rho5p binds to Ste50p, and the expression of the activated RHO5(Q91H) allele in an Δste50 strain is lethal under conditions of osmotic stress. An overexpression

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Sutherland, Jessie, Alexander Sobinoff, Kara Gunter, et al. "Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis." Biomolecules 5, no. 3 (2015): 1228–44. http://dx.doi.org/10.3390/biom5031228.

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44

Duggimpudi, S., J. Höll, and A. Borkhardt. "PS1017 MICRO RNA SIGNATURE OF ONCOGENIC MUSASHI RNA BINDING PROTEINS MSI1 AND MSI2." HemaSphere 3, S1 (2019): 458. http://dx.doi.org/10.1097/01.hs9.0000562364.92047.c1.

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Lugscheider, E., O. Knotek, S. Bärwulf, and K. Bobzin. "Characteristic curves of voltage and current, phase generation and properties of tungsten- and vanadium-oxides deposited by reactive d.c.-MSIP-PVD-process for self-lubricating applications." Surface and Coatings Technology 142-144 (July 2001): 137–42. http://dx.doi.org/10.1016/s0257-8972(01)01318-4.

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46

Arai, Hiroyuki, Shu Cao, Fotios Loupakis, et al. "Genetic variants in RNA binding protein (RBP) to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3, TRIBE, and MAVERICC trials." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3545. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3545.

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3545 Background: RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by stabilizing or destabilizing target messenger RNA. Although alteration of RBPs affects many steps of cancer development, its clinical implication in mCRC remains unclear. Methods: We analyzed data from mCRC patients (pts) enrolled in three first-line randomized trials (FIRE-3, TRIBE, and MAVERICC). Genomic DNA from blood samples of pts was genotyped through the OncoArray, a custom array manufactured by Illumina. Candidate 30 SNPs in 10 RBP genes (MSI1, MSI2, ELAVL1, RBM3, LIN28A, LIN28B, IGF2BP1, IG

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Kharas, Michael G., Christopher Lengner, Fatima Al-Shahrour, Benjamin L. Ebert, and George Q. Daley. "Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal." Blood 118, no. 21 (2011): 222. http://dx.doi.org/10.1182/blood.v118.21.222.222.

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Abstract Abstract 222 Genes that regulate normal hematopoietic stem cells are commonly dysregulated in hematopoietic malignancies. Recently we published that the Msi2 RNA binding protein is an important modulator in both normal hematopoietic stem cells and leukemia (Kharas et al, Nat. Medicine 2010). The closely related Msi1 protein has been shown to regulate mRNA translation through binding to the 3'UTR. Based on the high homology in the RNA recognition motifs, Msi2 has been considered to have similar functions. Moreover, increased MSI2 expression in chronic myelogenous leukemia blast crisis

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Nadvornikova, Sylvie, Marketa Zackova, Tereza Lopotova, Hana Klamova, and Jana Moravcova. "The Musashi 2 mRNA Expression in the Course of CML." Blood 120, no. 21 (2012): 2552. http://dx.doi.org/10.1182/blood.v120.21.2552.2552.

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Abstract Abstract 2552 The Musashi (MSI) gene family members, MSI1 and MSI2, represent an evolutionarily conserved family of RNA-binding proteins that regulate mRNA translation through binding in their N-termini. High levels of MSI2 protein are associated with increased cell proliferation, decreased cell maturation, more aggressive hematologic malignancy diseases and worse clinical prognosis. Recently obtained data pointed to MSI2 playing an important role in acute myeloid leukemia (AML) and in deadly blast crisis of chronic myeloid leukemia (CML) (Ito et al. 2010 Nature 5; 466). In this study

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Kim, Kyeong Ja, Christian Wöhler, Gwang Hyeok Ju, et al. "KOREAN LUNAR LANDER – CONCEPT STUDY FOR LANDING-SITE SELECTION FOR LUNAR RESOURCE EXPLORATION." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B4 (June 13, 2016): 417–23. http://dx.doi.org/10.5194/isprsarchives-xli-b4-417-2016.

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As part of the national space promotion plan and presidential national agendas South Korea’s institutes and agencies under the auspices of the Ministry of Science, Information and Communication Technology and Future Planning (MSIP) are currently developing a lunar mission package expected to reach Moon in 2020. While the officially approved Korean Pathfinder Lunar Orbiter (KPLO) is aimed at demonstrating technologies and monitoring the lunar environment from orbit, a lander – currently in pre-phase A – is being designed to explore the local geology with a particular focus on the detection and

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Kim, Kyeong Ja, Christian Wöhler, Gwang Hyeok Ju, et al. "KOREAN LUNAR LANDER – CONCEPT STUDY FOR LANDING-SITE SELECTION FOR LUNAR RESOURCE EXPLORATION." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B4 (June 13, 2016): 417–23. http://dx.doi.org/10.5194/isprs-archives-xli-b4-417-2016.

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As part of the national space promotion plan and presidential national agendas South Korea’s institutes and agencies under the auspices of the Ministry of Science, Information and Communication Technology and Future Planning (MSIP) are currently developing a lunar mission package expected to reach Moon in 2020. While the officially approved Korean Pathfinder Lunar Orbiter (KPLO) is aimed at demonstrating technologies and monitoring the lunar environment from orbit, a lander – currently in pre-phase A – is being designed to explore the local geology with a particular focus on the detection and

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