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Journal articles on the topic 'MSIP'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Wynia, K., AT van Wijlen, B. Middel, SA Reijneveld, and JF Meilof. "Change in disability profile and quality of life in multiple sclerosis patients: a five-year longitudinal study using the Multiple Sclerosis Impact Profile (MSIP)." Multiple Sclerosis Journal 18, no. 5 (September 30, 2011): 654–61. http://dx.doi.org/10.1177/1352458511423935.

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Background: Evidence on the progress of disease severity in Multiple Sclerosis (MS) is generally limited in scope. Objectives: To examine the course of a broad spectrum of MS-related disabilities and quality of life (QOL) in relation to disease severity, and responsiveness of the Multiple Sclerosis Impact Profile (MSIP). Methods: The mortality rate was calculated after checking the national population register for vital status of the initial cohort. We performed a longitudinal study among 245 patients with MS attending the Groningen MS Center in the Netherlands. We assessed these patients in 2004 and 2009 using a postal survey including the MSIP to evaluate disabilities, the World Health Organization Quality of Life-Abbreviation version (WHOQOL-BREF) to evaluate QOL, and the ambulation question of the Expanded Disability Status Scale (EDSS) to evaluate disease severity. Responsiveness of the MSIP was estimated using standardized response mean (SRM). Results: Increase of disability in the MSIP disability domains and loss of QOL were most prevalent and pronounced in patients with EDSS 0 to < 4.5 in 2004. MSIP and QOL scores were remarkably stable in the higher disease severity groups. Mortality rates were highest (24%) in patients with EDSS ≥ 7 to < 10 in 2004. SRM indices for the MSIP ranged between 0.26 and 0.56. Conclusions: Prominent increases in multiple aspects of disability and loss of QOL occur especially in the early stages in MS. Health care interventions may lead to health and QOL gains, in particular when offered to patients in the first stage of the MS process. Responsiveness was sufficient for nine of the 11 MSIP domains.

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2

Tung, Le Thanh. "Strong Karush–Kuhn–Tucker optimality conditions for multiobjective semi-infinite programming via tangential subdifferential." RAIRO - Operations Research 52, no. 4-5 (October 2018): 1019–41. http://dx.doi.org/10.1051/ro/2018020.

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The main aim of this paper is to study strong Karush–Kuhn–Tucker (KKT) optimality conditions for nonsmooth multiobjective semi-infinite programming (MSIP) problems. By using tangential subdifferential and suitable regularity conditions, we establish some strong necessary optimality conditions for some types of efficient solutions of nonsmooth MSIP problems. In addition to the theoretical results, some examples are provided to illustrate the advantages of our outcomes.

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3

Göçmen, Gökhan, Mehmet Oğuz Borahan, Sertac Aktop, Asım Dumlu, Filiz Namdar Pekiner, and Kamil Göker. "Effect of Septal Deviation, Concha Bullosa and Haller’s Cell on Maxillary Sinus’s Inferior Pneumatization; a Retrospective Study." Open Dentistry Journal 9, no. 1 (July 31, 2015): 282–86. http://dx.doi.org/10.2174/1874210601509010282.

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Purpose: Maxillary sinus’s inferior pneumatization is a physiological process, which increase with time and accelerates following extraction. The aim of this study was to determine the prevalence of nasal septal deviation (NSD), concha bullosa (CB), and Haller’s cells (HC) and to examine the correlation of maxillary sinus inferior pneumatization (MSIP) with these anatomical variations. Material and Methods : 300 (150 m, 150 f) CBCT scans taken at the Marmara University School of Dentistry from 2011 to 2014 were retrospectively reviewed for the presence of CB, NSD, HC and MSIP. The correlation between pneumatization to the anatomic variants was then compared. Data were analyzed with a Chi-square test. Results : Of the 300 CBCT scans, 44.3% have CB, 37.3% NSD, 19.3% HC and 27.7% MSIP. There was no statistical significancewhen comparing the relationship of patients with CB, NSD, HC and pneumatization. Conclusion : NSD, CB and HC do not have a definite role on sinus’s inferior pneumatization. Further studies should be conducted including potential factors related pneumatization with more sample size for further correlation with NSD, CB,HC.

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4

Manilla Garcia, A., I. Rivas Cambero, and J. A. Monroy Anieva. "Modelado y Análisis de Sintonización de Velocidad de un MSIP con Presencia de Fisura Mediante Algoritmos Genéticos." Revista Iberoamericana de Automática e Informática industrial 16, no. 2 (March 20, 2019): 190. http://dx.doi.org/10.4995/riai.2018.9767.

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<p>En el presente artículo se propone el modelado del sistema continuo correspondiente al motor síncrono de imanes permanentes (MSIP) con presencia de degradación en la inercia rotacional del rotor, mediante el mecanismo de fisura, lo cual permite la estimación de parámetros físicos, en el caso de análisis, el diámetro de la grieta presente en el rotor, disminuyendo con ello la incertidumbre en el modelado del MSIP. Se lleva a cabo la identificación en bucle cerrado de las ganancias mediante un análisis de sensibilidad, donde mediante el método computacional de optimización de búsqueda por algoritmos genéticos se obtienen las ganancias que logran converger el modelo propuesto al modelo de referencia.</p>

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5

Manilla-García, A., I. Rivas-Cambero, and N. F. Guerrero-Rodriguez. "Propuesta de modelo de variación de consumo de corriente de un MSIP por efecto de desbalance por presencia de grietas superficiales en el rotor." Revista Iberoamericana de Automática e Informática industrial 17, no. 4 (September 30, 2020): 424. http://dx.doi.org/10.4995/riai.2020.12200.

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<p>En el presente artículo se propone un modelo para caracterizar las variación de corriente en terminales de un motor síncrono de imanes permanentes (MSIP) como consecuencia del efecto de desbalance en el rotor a causa de una grieta superficial. Se modela el desbalance en el rotor mediante las ecuaciones de Laval con acoplamiento del efecto de la grieta superficial. Se propone un modelo de efecto de variación del entrehierro a partir de este desbalance, lo cual origina una variación en las inductancias del modelo del MSIP, que a su vez ocasionan una variación en el consumo de la corriente. Con este modelo se espera contribuir en el campo de determinación de parámetros físicos, en este caso, grietas o desbalances causados por imperfecciones que se comporten como tal.</p>

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6

Barahona Avalos, Jorge Luis, Rosalino Mayoral Lagunez, José Antonio Juárez Abad, Beatriz Angélica Aguilar López, and Jesús Linares Flores. "Control de velocidad de un motor síncrono de imanes permanentes accionado por un inversor trifásico multinivel." Ingenius, no. 23 (December 27, 2019): 97–108. http://dx.doi.org/10.17163/ings.n23.2020.09.

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Este trabajo presenta el diseño e implementación de un controlador robusto para el seguimiento de velocidad de un motor síncrono de imanes permanentes (MSIP). Se propone un controlador lineal basado en la retroalimentación dinámica de la salida pasiva estática del error exacto. El controlador pasivo propuesto requiere del conocimiento del par de carga, por lo que el mismo es estimado con un observador tradicional de orden reducido. El MSIP es impulsado por medio de un inversor multinivel trifásico de celdas en cascada de cinco niveles. Para la implementación del controlador, estimador y modulador multinivel se emplea un arreglo de compuertas programable en campo (FPGA) de la familia Spartan-6 XC6SLX9. El procesamiento en paralelo que provee este dispositivo permite obtener un tiempo de muestreo de 10 us. Los resultados de simulación y experimentales muestran que el controlador propuesto tiene un excelente desempeño.

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7

Koh, Seok, and Wook Hyun. "mSIP: Extension of SIP for Soft Handover with Bicasting." IEEE Communications Letters 12, no. 7 (July 2008): 532–34. http://dx.doi.org/10.1109/lcomm.2008.080335.

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8

Laraqui, A., A. Saaidi, and K. Satori. "MSIP: Multi-scale image pre-processing method applied in image mosaic." Multimedia Tools and Applications 77, no. 6 (April 6, 2017): 7517–37. http://dx.doi.org/10.1007/s11042-017-4659-0.

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9

Choong-Sik Chung and 진영빈. "Reallocation of public institution related ICT in accordance with launching MSIP." Korean Governance Review 20, no. 3 (December 2013): 1–25. http://dx.doi.org/10.17089/kgr.2013.20.3.001.

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10

Wynia, K., B. Middel, H. De Ruiter, J. P. Van Dijk, J. H. A. De Keyser, and S. A. Reijneveld. "Stability and relative validity of the Multiple Sclerosis Impact Profile (MSIP)." Disability and Rehabilitation 30, no. 14 (January 2008): 1027–38. http://dx.doi.org/10.1080/09638280701476193.

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11

von Richthofen, Alexander, Ralph Domnick, and Rainer Cremer. "Cu-N Films grown by reactive MSIP: Constitution, structure and morphology." Microchimica Acta 125, no. 1-4 (March 1997): 173–77. http://dx.doi.org/10.1007/bf01246182.

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12

AVER’YANOV, D. A. "INNOVATION POTENTIAL MANAGEMENT METHODS OF SMALL AND MEDIUM INNOVATIVE ENTERPRISES." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 2, no. 8 (2020): 48–57. http://dx.doi.org/10.36871/ek.up.p.r.2020.08.02.006.

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Based on the analysis of existing approaches, basic principles and management functions, a methodology for managing the innovative potential of small and medium-sized innovative enterprises has been developed. The activation of MSIP and the management of innovative potential are important scientific tasks, the solution of which will allow the Russian Federation to achieve the necessary rates of economic growth and ensure technological independence.

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13

Lugscheider, E., K. Bobzin, and A. Erdle. "Active soft solder deposition by magnetron-sputter-ion-plating (MSIP)-PVD-process." Thin Solid Films 447-448 (January 2004): 327–31. http://dx.doi.org/10.1016/s0040-6090(03)01110-6.

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14

Lugscheider, E., K. Bobzin, and A. Erdle. "Solder deposition for transient liquid phase (TLP)-bonding by MSIP-PVD-process." Surface and Coatings Technology 174-175 (September 2003): 704–7. http://dx.doi.org/10.1016/s0257-8972(03)00692-3.

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15

Gunda, Naga Siva Kumar, Minashree Singh, Yashasvi Purwar, Sirish L. Shah, Kamaljit Kaur, and Sushanta K. Mitra. "Micro-spot with integrated pillars (MSIP) for detection of dengue virus NS1." Biomedical Microdevices 15, no. 6 (July 5, 2013): 959–71. http://dx.doi.org/10.1007/s10544-013-9787-3.

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16

Correa-Casas, Juan Diego, Diego Steven Rayo-Villamizar, and Javier Enrique Solano-Martínez. "Representación energética macroscópica y simulación de una máquina síncrona de imanes permanentes." Respuestas 25, no. 3 (September 1, 2020): 154–64. http://dx.doi.org/10.22463/0122820x.1856.

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Este artículo presenta un modelo de simulación de la máquina síncrona de imanes permanentes (MSIP) y su sistema de control de velocidad utilizando el formalismo de la Representación Energética Macroscópica (REM). Esta descripción gráfica permite realizar un esquema de control basado en la inversión del modelo de la máquina. Los modelos se validan mediante comparación con resultados presentados en la literatura. Para mostrar la utilidad del modelo presentado, se presentan resultados de simulación de la máquina ante diferentes condiciones de operación y referencias de control.

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17

Sarwindah, Sarwindah, Marini Marini, and Tirta Aditya Pratama. "Implementasi MSIP (Manajemen Sistem Informasi Pendistribusian) Keluar Masuk Obat Pada Gudang Farmasi Kelapa." JURNAL MEDIA INFORMATIKA BUDIDARMA 4, no. 2 (April 25, 2020): 332. http://dx.doi.org/10.30865/mib.v4i2.1952.

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The process of drug distribution is one of the main processes in drug management which has an important role in managing drug availability. In its implementation, the drug distribution process requires information regarding the receipt, supply and expenditure of the drug between the sending and receiving parties, where the information can be changed periodically according to the entry and exit of the drug. Therefore Pharmacy Pharmacy warehouse in Kelapa Puskesmas which has the task of distributing drugs to sub-service units should be able to meet the needs in managing information on the drug distribution process. This research was conducted to analyze and design "Web-Based Drug Distribution Information System in Coconut Pharmacy Warehouse". In this research, the research method used by the author is the Oriented Object method with case studies in the distribution of drugs and to design information systems using the Oriented object approach and for the development method using the UML method.it can be seen that the Drug Distribution Information System in the Web-Based Coconut Pharmacy Warehouse is currently experiencing problems, because there are some data processing processes that are still conventional in nature, and there is still no integration of drug inventory data with drug sales data and so forth

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18

Bobzin, K., N. Bagcivan, T. Brögelmann, and T. Münstermann. "Development and qualification of a MSIP PVD iridium coating for precision glass moulding." Materialwissenschaft und Werkstofftechnik 44, no. 8 (August 2013): 673–78. http://dx.doi.org/10.1002/mawe.201300174.

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19

von Richthofen, A., and R. Domnick. "Metastable single-phase polycrystalline aluminium oxynitride films grown by MSIP: constitution and structure." Thin Solid Films 283, no. 1-2 (September 1996): 37–44. http://dx.doi.org/10.1016/0040-6090(95)08256-5.

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20

McLaughlin, E. A., B. A. Fraser, V. Pye, M. Bigland, N. A. Siddall, and G. R. Hime. "167. MUSASHI FAMILY OF RNA BINDING PROTEINS: CELL CYCLE REGULATORS IN SPERMATOGENESIS." Reproduction, Fertility and Development 22, no. 9 (2010): 85. http://dx.doi.org/10.1071/srb10abs167.

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Mammalian meiosis is a tightly regulated process involving specialized cell cycle progression and morphogenetic changes. We have demonstrated that the Musashi family of RNA binding proteins is implicated in the regulation of spermatogonial stem self renewal and germ cell differentiation. Here we describe the novel mechanism by which the Musashi family proteins, Msi1 and Msi2, act to control exit from spermatogonial mitotic amplification and normal entry into meiosis. Gene and protein analysis indicated overlapping Msi1 and Msi2 profiles in enriched populations of isolated germ cells and reciprocal subcellular expression patterns in spermatogonia and pachytene spermatocytes/ round spermatids in testes sections. Recombinant Msi1 protein-RNA pulldown and microarray analysis coupled with in vitro shRNA knockdown studies in spermatogonial culture and subsequent immunoprecipitation and qPCR established that Msi1 targeted Msi2 mRNA for post transcriptional translational repression. Immunoprecipitation of Msi2 target mRNA and subsequent qPCR together with in vitro shRNA knockdown studies inround spermatidculture identified a cell cycle inhibitor protein CDKN1C (p57kip2) as the principal target of Msi2 translational inhibition. Immunolocalisation of CDKN1C protein indicated that expression of this cell cycle regulator coincided with the nuclear import of Msi1 and the appearance of cytoplasmic Msi2 expression in early pachytene spermatocytes. Using a transgenic Msi1 overexpression mouse model in conjunction with quantitative gene and protein expression, we confirmed Msi1 targeting of Msi2 and subsequent Msi2 targeting of CDKN1C for translational repression in vivo. Ectopic overexpression of Msi1 in germ cellsinduces substantial Msi2 downregulation and aberrant CDKN1C expression, resulting in abnormal spermatogenic differentiation, germ cell apoptosis/arrest and sterility. In conclusion, our results indicate a sophisticated molecular switch encompassing cell cycle protein regulation by Musashi family proteins, is required for normal exit from mitotic division, entry into meiosis and post meiotic germ cell differentiation.

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21

Zhang, Ning, Chun Hong Zhang, and Ying Huai Qiang. "Property Study on High-Speed Steel Deposited TiN Coatings by Magnetron Sputter Ion Plating." Applied Mechanics and Materials 275-277 (January 2013): 1866–69. http://dx.doi.org/10.4028/www.scientific.net/amm.275-277.1866.

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TiN coatings were deposited by Magnetron Sputter Ion Plating (MSIP) on the surface of high-speed steel W18Cr4V.The microstructure,coating thickness, micro-hardness and wear resistance of surface modification sample were investigated by the D/MAX-ⅢB X-ray diffraction tester, the coating thickness tester, the HV-1000 micro-sclerometer,the LKDM－2000 friction and wear tester,the S-3000N scaning electron microscopy.The influence of sputtering time,N2 partial pressures and sputtering current on the microstructure,coating thickness, micro-hardness and wear resistance of TiN coatings were also analysed.The best synthesis performance sputtering coatings of technologic scheme was established.

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22

Lugscheider, E., S. Bärwulf, and C. Barimani. "Properties of tungsten and vanadium oxides deposited by MSIP–PVD process for self-lubricating applications." Surface and Coatings Technology 120-121 (November 1999): 458–64. http://dx.doi.org/10.1016/s0257-8972(99)00467-3.

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23

von Richthofen, Alexander, Rainer Cremer, and Dieter Neuschütz. "Morphology, structure and constitution of metastable single-phase Ti1-xAlxN films grown by reactive MSIP." Microchimica Acta 125, no. 1-4 (March 1997): 143–48. http://dx.doi.org/10.1007/bf01246177.

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24

Zhang, Byoung-Tak. "Humans and Machines in the Evolution of AI in Korea." AI Magazine 37, no. 2 (July 4, 2016): 108–12. http://dx.doi.org/10.1609/aimag.v37i2.2656.

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Artificial intelligence in Korea is currently prospering. The media is regularly reporting AI-enabled products such as smart advisors, personal robots, autonomous cars, and human-level intelligence machines. The IT industry is investing in deep learning and AI to maintain the global competitive edge in their services and products. The Ministry of Science, ICT, and Future Planning (MSIP) has launched new funding programs in AI and cognitive science to implement the government’s newly adopted endeavor of building a “Creative Economy” and “Software Centric Society”. However, AI was not always flourishing as it is now. Similar to the history of AI worldwide, AI research and industry in Korea have faced both the ups and downs in its history.

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25

Yang, Dong-Hoon, Shinae Maeng, and Yong-Sun Bahn. "Msi1-Like (MSIL) Proteins in Fungi." Mycobiology 41, no. 1 (March 2013): 1–12. http://dx.doi.org/10.5941/myco.2013.41.1.1.

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26

de Waard, Hester. "De Multiple Sclerosis Impact Profile (MSIP): een meetinstrument voor MS-gerelateerde functioneringsproblemen en de beleving daarvan." Nederlands Tijdschrift voor Evidence Based Practice 6, no. 1 (February 2008): 9–11. http://dx.doi.org/10.1007/bf03077152.

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27

Wynia, Klaske, Berrie Middel, Jitse P. van Dijk, Han de Ruiter, Jacques De Keyser, and Sijmen A. Reijneveld. "The Multiple Sclerosis Impact Profile (MSIP). Development and testing psychometric properties of an ICF-based health measure." Disability and Rehabilitation 30, no. 4 (January 2008): 261–74. http://dx.doi.org/10.1080/09638280701256868.

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28

Bobzin, Kirsten, Nazlim Bagcivan, and Philipp Immich. "Deposition of Oxides as Tool Protection for Large Thixoforming Dies by Using the Pulsed MSIP-PVD Process." Solid State Phenomena 141-143 (July 2008): 249–54. http://dx.doi.org/10.4028/www.scientific.net/ssp.141-143.249.

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Oxide coatings offer great potential for their use in forming operations in the semi-solid state. Advantages of these types of coatings are high resistance against abrasive wear, high hot hardness and low thermal conductivity. Nevertheless deposition by pulsed Magnetron Sputter Ion Plating-PVD for oxide coatings is quite challenging: deposition rates are low and insulating layers on the target surface can cause arcing. On laboratory scale it was possible to deposit γ-Alumina using PVD in a temperature range, where hot working steel can be utilized. The next important step in the development towards an industrial application for larger forming tools is the upscaling process to larger coating units. In this work the process development of oxide coatings on an industrial coating unit for large tools was described. To increase adhesion of oxide top-layer additional bond coats were applied. Different process parameters like oxygen content, total pressure and substrate bias were varied, to improve the performance. The relationship between coating properties and process parameters of the deposited films were characterized by X-Ray-diffraction, Nanoindentation and Scanning Electron Microscopy (SEM). By using reactive pulsed PVD-process it was possible to deposit γ-Al2O3 on large steel tools for semi-solid melt protection. The developed coatings showed for thixoforging processes of X210CrW12 an extraordinary stability in field tests. The lifetime of the permanent moulds was increased by using PVD thin film coatings as a tool protection.

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29

Wynia, Klaske, Petrie F. Roodbol, and Berry Middel. "Meten van functioneringsproblemen én de beleving ervan bij mensen met Multiple Sclerose: de Multiple Sclerosis Impact Profile (MSIP)." Psychologie en Gezondheid 37, no. 3 (June 2009): 165–76. http://dx.doi.org/10.1007/bf03080390.

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30

Bobzin, K., N. Bagcivan, M. Ewering, R. H. Brugnara, and S. Theiß. "DC-MSIP/HPPMS (Cr,Al,V)N and (Cr,Al,W)N thin films for high-temperature friction reduction." Surface and Coatings Technology 205, no. 8-9 (January 2011): 2887–92. http://dx.doi.org/10.1016/j.surfcoat.2010.10.056.

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31

Bagcivan, N., K. Bobzin, and R. H. Brugnara. "Investigation of the properties of low temperature (Cr1-x Alx )N coatings deposited via hybrid PVD DC-MSIP/HPPMS." Materialwissenschaft und Werkstofftechnik 44, no. 8 (August 2013): 667–72. http://dx.doi.org/10.1002/mawe.201300173.

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32

Middel, Berry. "Meten van functioneringsproblemen én de gepercipieerde ernst ervan bij mensen met multiple sclerose: de Multiple Sclerosis Impact Profile (MSIP)1)." Nederlands Tijdschrift voor Evidence Based Practice 9, no. 3 (July 2011): 11–12. http://dx.doi.org/10.1007/s12468-011-0025-9.

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33

Bobzin, K., N. Bagcivan, M. Ewering, R. H. Brugnara, and T. Münstermann. "Influence of interlayer thickness of a thin noble metal MSIP-PVD coating on compound and system properties for glass lens moulding." Production Engineering 6, no. 3 (May 6, 2012): 311–18. http://dx.doi.org/10.1007/s11740-012-0385-7.

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34

Horisawa, Kenichi, Takao Imai, Hideyuki Okano, and Hiroshi Yanagawa. "The Musashi family RNA-binding proteins in stem cells." BioMolecular Concepts 1, no. 1 (May 1, 2010): 59–66. http://dx.doi.org/10.1515/bmc.2010.005.

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AbstractThe Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which encode regulators of signal transduction and the cell cycle. Recently, strong expression of Msi1 in various somatic stem/progenitor cells of adult tissues, such as eye, gut, stomach, breast, and hair follicle, has been reported. The protein is also expressed in various cancer cells, and ectopically emerging cells have been found in neural tissues of patients with diseases involving neural disorder, including epilepsy. Many novel target mRNAs and regulatory pathways of Msi1 have been reported in recent years. Here, we present a review of the functions and action mechanisms of Msi1 protein and discuss possible directions for further study.

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35

Lugscheider, E., K. Bobzin, N. Papenfuß-Janzen, M. Maes, and D. Parkot. "Plasma diagnostical comparison of the MSIP process of (Ti,Al)N with pulsed and dc power supplies using energy-resolved mass spectroscopy." Surface and Coatings Technology 188-189 (November 2004): 164–67. http://dx.doi.org/10.1016/j.surfcoat.2004.08.011.

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36

Bošanský, Miroslav, Ernest Gondár, Pavol Švec, František Toth, and Roman Protasov. "A Study of Wear in Thin Coatings Applied to Convex-Concave Gearings." Lubricants 8, no. 5 (May 16, 2020): 56. http://dx.doi.org/10.3390/lubricants8050056.

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The submitted contribution deals with the wear of thin coatings applied to convex–concave gearings for gear made from C45E steel. The influence of the tribological characteristics (friction coefficient, wear, adhesion and hardness) of the TiN, TiCN coatings and the combined coating of TiCN + MoS2 on convex–concave gearing is described, from the aspects of scuffing formation. Scuffing tests were done on C–C gears. Coatings were applied by arc–ion-plating (AIP) and magnetron sputter-ion-plating (MSIP) methods. The thickness of the deposited coating and its chemical composition were determined by SEM and EDX analysis. Load-bearing capacity was evaluated by a Niemann tester. The TiCN + MoS2 combined coating with the MoS2 layer on the top reached the lowest coefficient of friction. However, after a rapid wearing of the MoS2 layer, this value dropped to a comparable value of TiCN. The nano-hardness of the TiCN layer was higher in comparison with TiN. Thin and soft MoS2 layers cracked already at lower load levels and separated from the substrate at the 5th load stage. The formation of scuffings for selected coatings documented in this article was solved for convex–concave gearing working also in interaction with Biogear S 150 and Biohyd MS 46 oils.

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37

Wynia, K., B. Middel, JP van Dijk, JHA De Keyser, and SA Reijneveld. "The impact of disabilities on quality of life in people with multiple sclerosis." Multiple Sclerosis Journal 14, no. 7 (June 23, 2008): 972–80. http://dx.doi.org/10.1177/1352458508091260.

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Objective People with Multiple Sclerosis (MS) experience lower levels of quality of life (QOL) than people from the general population. We examined the relative impact of MS-related disabilities on QOL. Method Data were obtained from a sample of 530 patients who completed the Multiple Sclerosis Impact Profile (MSIP), a disability measure based on the International Classification of Functioning,Disabilities and Health (ICF) and two generic health-related QOL measures, the Medical Outcome study Short Form Questionnaire (SF-36) and the World Health Organization Quality Of Life-BREF (WHOQOL-BREF). The impact of disabilities on QOL was estimated using hierarchical multiple regression analyses after controlling for the clinical course of MS. Results Disabilities contributed to a unique and substantial extent to QOL variance. “Impairments in mental functions” was the most important QOL predictor. “Fatigue” showed the highest prevalence and severity scores, while the impact on QOL was limited. The estimated impact on QOL appeared to be dependent on the applied QOL measure: the WHOQOL-BREF was sensitive to disabilities related to all four ICF components, while the SF-36 was only sensitive to disabilities belonging to the 'body functions' and ‘activities’ components. Conclusion Treatment programmes should target impairments in cognitive functioning, emotional functioning and sleep. Interventions are best evaluated using the WHOQOL-BREF.

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Wynia, Klaske, and Berry Middel. "De Multiple Sclerosis Impact Profile (msip): een nieuw instrument voor het meten van functioneringsproblemen en de beleving ervan bij mensen met multiple sclerose." Neuropraxis 12, no. 6 (December 2008): 185–93. http://dx.doi.org/10.1007/bf03077145.

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Lan, Lan, Jiajun Liu, Minli Xing, Amber R. Smith, Jinan Wang, Xiaoqing Wu, Carl Appelman, et al. "Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction." Cancers 12, no. 8 (August 8, 2020): 2221. http://dx.doi.org/10.3390/cancers12082221.

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RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21WAF-1, key regulators of Notch/Wnt signaling and cell cycle progression, respectively. In this study, we aim to identify small molecule inhibitors of MSI1–mRNA interactions, which could block the growth of cancer cells with high levels of MSI1. Using a fluorescence polarization (FP) assay, we screened small molecules from several chemical libraries for those that disrupt the binding of MSI1 to its consensus RNA. One cluster of hit compounds is the derivatives of secondary metabolites from Aspergillus nidulans. One of the top hits, Aza-9, from this cluster was further validated by surface plasmon resonance and nuclear magnetic resonance spectroscopy, which demonstrated that Aza-9 binds directly to MSI1, and the binding is at the RNA binding pocket. We also show that Aza-9 binds to Musashi-2 (MSI2) as well. To test whether Aza-9 has anti-cancer potential, we used liposomes to facilitate Aza-9 cellular uptake. Aza-9-liposome inhibits proliferation, induces apoptosis and autophagy, and down-regulates Notch and Wnt signaling in colon cancer cell lines. In conclusion, we identified a series of potential lead compounds for inhibiting MSI1/2 function, while establishing a framework for identifying small molecule inhibitors of RNA binding proteins using FP-based screening methodology.

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Lugscheider, E., O. Knotek, K. Bobzin, and S. Bärwulf. "Tribological properties, phase generation and high temperature phase stability of tungsten- and vanadium-oxides deposited by reactive MSIP-PVD process for innovative lubrication applications." Surface and Coatings Technology 133-134 (November 2000): 362–68. http://dx.doi.org/10.1016/s0257-8972(00)00963-4.

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Mu, Qitian, Yungui Wang, Bing Chen, Wenbin Qian, Haitao Meng, Hongyan Tong, Feifei Chen, et al. "High Musashi-2 Expression Is an Unfavorable Prognostic Factor in Adult B-Cell Acute Lymphoblastic Leukemia." Blood 120, no. 21 (November 16, 2012): 2508. http://dx.doi.org/10.1182/blood.v120.21.2508.2508.

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Abstract Abstract 2508 Background: Musashi-2 (MSI2) can inhibit translation of the mRNA encoding NUMB, the NOTCH signaling inhibitor, and play a vital role in the maintenance of hematopoietic stem cells. Musashi-1 (MSI1), another isoform of Musashi family, positively regulates NOTCH1 expression. Recent studies have demonstrated that MSI2 expression was up-regulated during chronic myelogenous leukemia (CML) progression and its high expression was associated with poor outcome of CML and acute myeloid leukemia (AML). However, the prognostic significance of MSI2 expression and the relation between MSI2 and NOTCH1 expressions in acute lymphoblastic leukemia (ALL) remain unknown. Methods: In this study, real-time PCR was used to measured expression levels of MSI2 and NOTCH1 signaling related genes in 116 B-ALL and 24 T-ALL patients, in whom more than 70% leukemic cells were morphologically detected in bone morrow (BM) at diagnosis. Clinical and Molecular data in relation with MSI2 expression level were analyzed. Results: In our B-ALL cohort, although MSI2 expression was not associated with gender, age, white blood cell (WBC), t(9;22)/BCR-ABL and IK6 variant of IKZF1, patients with high MSI2 expression had inferior overall survival (OS) (P=0.007) and event free survival (EFS) (P=0.002) than patients with low MSI2 expression. Multivariate analysis showed that high MSI2 expression was an independently prognosic factor in OS (P=0.001, HR=2.641, 95%CI, 1.494–4.668), EFS (P<0.001, HR=2.562, 95%CI, 1.513–4.218) and RFS (P=0.043, HR=2.057, 95%CI, 1.023–4.137). Moreover, MSI2 expression level had a positive correlation with that of NOTCH1 (P<0.001), but not c-MYC (P=0.432) or HES1 (P=0.509). Similarly, NOTCH1 expression level in patients with high MSI2 expression (0.98, range 0.02 to 13.58) was significantly higher than that in patients with low MSI2 expression (0.42, range 0.01 to 3.55, P=0.001), but c-MYC and HES1 expression levels between patients with high MSI2 expression and low MSI2 expression showed no significant differences (both P>0.05). Conclusion: Our data suggests MSI2 high expression can indicate poor prognosis in adult B-ALL accompanying with elevated NOTCH1 expression but not activating NOTCH1 downstream pathway. Disclosures: No relevant conflicts of interest to declare.

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Annan, Robert B., Cunle Wu, Daniel D. Waller, Malcolm Whiteway, and David Y. Thomas. "Rho5p Is Involved in Mediating the Osmotic Stress Response in Saccharomyces cerevisiae, and Its Activity Is Regulated via Msi1p and Npr1p by Phosphorylation and Ubiquitination." Eukaryotic Cell 7, no. 9 (July 11, 2008): 1441–49. http://dx.doi.org/10.1128/ec.00120-08.

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ABSTRACT Small GTPases of the Rho family act as molecular switches, and modulation of the GTP-bound state of Rho proteins is a well-characterized means of regulating their signaling activity in vivo. In contrast, the regulation of Rho-type GTPases by posttranslational modifications is poorly understood. Here, we present evidence of the control of the Saccharomyces cerevisiae Rho-type GTPase Rho5p by phosphorylation and ubiquitination. Rho5p binds to Ste50p, and the expression of the activated RHO5(Q91H) allele in an Δste50 strain is lethal under conditions of osmotic stress. An overexpression screen identified RGD2 and MSI1 as being high-copy suppressors of the osmotic sensitivity of this lethality. Rgd2p had been identified as being a possible Rho5p GTPase-activating protein based on an in vitro assay; this result supports its function as a regulator of Rho5p activity in vivo. MSI1 was previously identified as being a suppressor of hyperactive Ras/cyclic AMP signaling, where it antagonizes Npr1p kinase activity and promotes ubiquitination. Here, we show that Msi1p also acts via Npr1p to suppress activated Rho5p signaling. Rho5p is ubiquitinated, and its expression is lethal in a strain that is compromised for proteasome activity. These data identify Rho5p as being a target of Msi1p/Npr1p regulation and describe a regulatory circuit involving phosphorylation and ubiquitination.

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Sutherland, Jessie, Alexander Sobinoff, Kara Gunter, Barbara Fraser, Victoria Pye, Ilana Bernstein, Evan Boon, et al. "Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis." Biomolecules 5, no. 3 (June 26, 2015): 1228–44. http://dx.doi.org/10.3390/biom5031228.

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Duggimpudi, S., J. Höll, and A. Borkhardt. "PS1017 MICRO RNA SIGNATURE OF ONCOGENIC MUSASHI RNA BINDING PROTEINS MSI1 AND MSI2." HemaSphere 3, S1 (June 2019): 458. http://dx.doi.org/10.1097/01.hs9.0000562364.92047.c1.

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Lugscheider, E., O. Knotek, S. Bärwulf, and K. Bobzin. "Characteristic curves of voltage and current, phase generation and properties of tungsten- and vanadium-oxides deposited by reactive d.c.-MSIP-PVD-process for self-lubricating applications." Surface and Coatings Technology 142-144 (July 2001): 137–42. http://dx.doi.org/10.1016/s0257-8972(01)01318-4.

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Arai, Hiroyuki, Shu Cao, Fotios Loupakis, Sebastian Stintzing, Ryuma Tokunaga, Francesca Battaglin, Jae Ho Lo, et al. "Genetic variants in RNA binding protein (RBP) to predict outcome in metastatic colorectal cancer (mCRC): Data from FIRE-3, TRIBE, and MAVERICC trials." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 3545. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3545.

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3545 Background: RNA binding proteins (RBPs) post-transcriptionally regulate gene expression by stabilizing or destabilizing target messenger RNA. Although alteration of RBPs affects many steps of cancer development, its clinical implication in mCRC remains unclear. Methods: We analyzed data from mCRC patients (pts) enrolled in three first-line randomized trials (FIRE-3, TRIBE, and MAVERICC). Genomic DNA from blood samples of pts was genotyped through the OncoArray, a custom array manufactured by Illumina. Candidate 30 SNPs in 10 RBP genes (MSI1, MSI2, ELAVL1, RBM3, LIN28A, LIN28B, IGF2BP1, IGF2BP2, IGF2BP3, ZFP36) were tested on association with progression-free survival (PFS) and overall survival (OS). To evaluate prognostic effects and heterogeneities across treatment arms, meta-analysis approach using the METASOFT software was conducted. We also tested interaction between each SNP and treatment within each trial, i.e. FIRE-3 cohort (FOLFIRI+cetuximab (Cet) vs FOLFIRI+bevacizumab (Bev)) and MAVERICC cohort (FOLFIRI+Bev vs FOLFOX6+Bev). For multiple testing, p values were adjusted by the false discovery rate (FDR) method. Results: A total of 884 pts’ SNPs data were available (FIRE-3: n = 236, TRIBE: n = 324, and MAVERICC: n = 324). Meta-analysis combining three trials showed RBM3 rs926152 (adjusted p = 0.045) and RBM3 rs2249585 (adjusted p = 0.016) were significantly prognostic for PFS. Whereas, in terms of OS, only LIN28B rs314277 (adjusted p = 0.045) was significant, and RBM3 rs926152 (adjusted p = 0.057) and RBM3 rs2249585 (adjusted p = 0.059) had a trend. Interaction test showed several SNPs were potentially predictive (raw p < 0.05), although without any significance after FDR adjustment: in FIRE-3 cohort, MSI2 rs1822381, RBM3 rs926152, LIN28B rs221635, IGF2BP1 rs2969 for OS; in MAVERICC cohort, MSI1 rs1179442 and MSI2 rs3826301 for OS, ELAVL1 rs4804244 for PFS. Conclusions: Our results indicate prognostic potential of SNPs in RBP genes, such as RBM3 and LIN28B, in mCRC. However, we find no distinct evidence that these SNPs can predict differential effect between Cet and Bev, or between oxaliplatin- and irinotecan-based chemotherapy.

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Kharas, Michael G., Christopher Lengner, Fatima Al-Shahrour, Benjamin L. Ebert, and George Q. Daley. "Msi2 Maintains Normal Hematopoietic Stem Cell Self-Renewal." Blood 118, no. 21 (November 18, 2011): 222. http://dx.doi.org/10.1182/blood.v118.21.222.222.

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Abstract Abstract 222 Genes that regulate normal hematopoietic stem cells are commonly dysregulated in hematopoietic malignancies. Recently we published that the Msi2 RNA binding protein is an important modulator in both normal hematopoietic stem cells and leukemia (Kharas et al, Nat. Medicine 2010). The closely related Msi1 protein has been shown to regulate mRNA translation through binding to the 3'UTR. Based on the high homology in the RNA recognition motifs, Msi2 has been considered to have similar functions. Moreover, increased MSI2 expression in chronic myelogenous leukemia blast crisis and acute myeloid leukemia predicts a worse clinical prognosis. Previous studies have mainly utilized shRNAs to functionally assess the role of Msi2 in the hematopoietic compartment. However, it remains unclear how Msi2 affects hematopoietic stem cells (HSC) and what are its critical mRNA targets. To develop a model focusing on the HSC compartment and to avoid potential compensatory mechanisms during development, we created Msi2 conditional knockout mice and crossed them with Mx1-Cre mice. We induced excision with poly(I):poly(C), (pIpC), and tested the peripheral blood, bone marrow cells and splenocytes by Southern blotting and QPCR analysis to verify Msi2 deletion. Loss of Msi2 mRNA was confirmed in the Lineagelo, Sca1+ and c-Kit+ (LSK) population. Msi2 deleted bone marrow contained reduced myeloid colony forming capacity and replating efficiency. Mice conditionally deleted for Msi2 had normal white blood cell counts but smaller spleens. In addition, we observed normal percentages of the mature hematopoietic populations, including the myeloid and lymphoid compartments. Nevertheless, absolute numbers of long-term HSCs in the bone marrow were reduced by 3-fold. Bone marrow cells non-competitively transplanted into primary and secondary recipient mice showed a dramatic reduction in HSC chimerism. This defect was also observed when bone marrow was transplanted first to allow engraftment followed by Msi2 deletion. Furthermore, we were able to recapitulate this defect in vitro using the cobblestone-forming activity assay. These results indicate that Msi2 is both an important regulator of normal HSC maintenance and required for efficient engraftment. Most interestingly, Msi2 HSCs failed to maintain a normal quiescent HSC population. We performed microarrays to identify the pathways altered in the LSK population. The Msi2 deficient LSKs showed a reduced self-renewal and increased differentiation gene signature. Gene expression analysis indicates a defective self-renewal program in Msi2-deficient HSCs that is identical to the program gained in leukemic stem cells. These data suggest that MSI2 is a critical modulator of HSCs and may help explain its requirement in the most aggressive myeloid leukemias. Disclosures: Daley: iPierian, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Epizyme, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Verastem, Inc: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Solasia, KK: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; MPM Capital, Inc: Consultancy, Membership on an entity's Board of Directors or advisory committees; Johnson & Johnson: Membership on an entity's Board of Directors or advisory committees.

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Nadvornikova, Sylvie, Marketa Zackova, Tereza Lopotova, Hana Klamova, and Jana Moravcova. "The Musashi 2 mRNA Expression in the Course of CML." Blood 120, no. 21 (November 16, 2012): 2552. http://dx.doi.org/10.1182/blood.v120.21.2552.2552.

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Abstract Abstract 2552 The Musashi (MSI) gene family members, MSI1 and MSI2, represent an evolutionarily conserved family of RNA-binding proteins that regulate mRNA translation through binding in their N-termini. High levels of MSI2 protein are associated with increased cell proliferation, decreased cell maturation, more aggressive hematologic malignancy diseases and worse clinical prognosis. Recently obtained data pointed to MSI2 playing an important role in acute myeloid leukemia (AML) and in deadly blast crisis of chronic myeloid leukemia (CML) (Ito et al. 2010 Nature 5; 466). In this study we screened the level of MSI2 mRNA in 49 patients in different phases of CML and with different response to therapy – 18 patients at diagnosis (DG), 5 in major molecular response (MMR), 4 in complete molecular response (CMR), 2 after bone marrow transplantation (BMT), 10 in hematology relaps (HR), 6 in accelerrated phase (AP), and 4 in blast crisis (BC), and in 6 healthy donors. The level of MSI2 mRNA was quantified by real-time reverse-transcriptase-polymerase chain reaction using in-house designed specific primers and TaqMan probe and normalized to B2M endogenous control. Expression ratios were calculated by ΔΔCt method, and the differences between groups were statistically evaluated using Mann Whitney test. We detected MSI2 expression in all samples. The median expression of mRNA MSI2 in patients at DG was 1,43 (0,33–3,28), in MMR 0,52 (0,20–0,62), in CMR 0,37 (0,30–0,63), after BMT 1,28 (1,02–1,54), in HR 0,41 (0,16–0,58), in AP 3,78 (1,94–13,69), in BC 15,17 (2,61–28,15). MSI2 expression was statistically up-regulated in patients in advanced phases of CML (AP, BC) when compared with patients in CP (P<0.0001). The difference between patients in DG and remaining patients in CP was also statistically significant (P= 0,0006). No correlation of MSI2 expression level in DG patients with their responsiveness to treatment, BCR-ABL transcript level or survival was found. No significant differences were observed among groups of patients in MMR, CMR, HR, and after BMT. In addition, in order to check whether MSI2 expression level can serve as a marker of CML progression we also retrospectively screened kinetics of MSI2 transcript in 5 CML patients monitored on average 27 months (18–48). During this period, 3 patients developed HR, 1 patient AP and 1 BC. In BC patient the MSI2 transcript level increased with progression of CML in accordance with the increase of leucocytes and BCR-ABL transcript level. In 1 patient with a rising AP BCR-ABL levels remained constant compared to sevenfold increase of the MSI2 transcript level. On the other hand in HR patients we detected a constant or even decreasing level of MSI2 transcript regardless of the increase of leucocytes and BCR-ABL. In summary, our results confirm the association of high MSI2 mRNA level with advanced phases of CML and indicate that increase of MSI2 mRNA level may serve as a valuable marker of advanced phases of CML. In particular for CML patients with constantly high level of BCR-ABL mRNA the monitoring of MSI2 level can be important tool for early recognition of CML progression. Potential contributions of MSI2 to leukemic pathogenesis and its regulation in CML progression remain unknown. Grant support: NT/12392-4 IGA MZ-CR. Disclosures: No relevant conflicts of interest to declare.

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Kim, Kyeong Ja, Christian Wöhler, Gwang Hyeok Ju, Seung–Ryeol Lee, Alexis P. Rodriguez, Alexey A. Berezhnoy, Stephan van Gasselt, Arne Grumpe, and Rabab Aymaz. "KOREAN LUNAR LANDER – CONCEPT STUDY FOR LANDING-SITE SELECTION FOR LUNAR RESOURCE EXPLORATION." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B4 (June 13, 2016): 417–23. http://dx.doi.org/10.5194/isprsarchives-xli-b4-417-2016.

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As part of the national space promotion plan and presidential national agendas South Korea’s institutes and agencies under the auspices of the Ministry of Science, Information and Communication Technology and Future Planning (MSIP) are currently developing a lunar mission package expected to reach Moon in 2020. While the officially approved Korean Pathfinder Lunar Orbiter (KPLO) is aimed at demonstrating technologies and monitoring the lunar environment from orbit, a lander – currently in pre-phase A – is being designed to explore the local geology with a particular focus on the detection and characterization of mineral resources. In addition to scientific and potential resource potentials, the selection of the landing-site will be partly constrained by engineering constraints imposed by payload and spacecraft layout. Given today’s accumulated volume and quality of available data returned from the Moon’s surface and from orbital observations, an identification of landing sites of potential interest and assessment of potential hazards can be more readily accomplished by generating synoptic snapshots through data integration. In order to achieve such a view on potential landing sites, higher level processing and derivation of data are required, which integrates their spatial context, with detailed topographic and geologic characterizations. We are currently assessing the possibility of using fuzzy c-means clustering algorithms as a way to perform (semi-) automated terrain characterizations of interest. This paper provides information and background on the national lunar lander program, reviews existing approaches – including methods and tools – for landing site analysis and hazard assessment, and discusses concepts to detect and investigate elemental abundances from orbit and the surface. This is achieved by making use of manual, semi-automated as well as fully-automated remote-sensing methods to demonstrate the applicability of analyses. By considering given boundary conditions, concrete procedures for determining potential landing sites of the Korean lunar lander could be proposed.

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Kim, Kyeong Ja, Christian Wöhler, Gwang Hyeok Ju, Seung–Ryeol Lee, Alexis P. Rodriguez, Alexey A. Berezhnoy, Stephan van Gasselt, Arne Grumpe, and Rabab Aymaz. "KOREAN LUNAR LANDER – CONCEPT STUDY FOR LANDING-SITE SELECTION FOR LUNAR RESOURCE EXPLORATION." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLI-B4 (June 13, 2016): 417–23. http://dx.doi.org/10.5194/isprs-archives-xli-b4-417-2016.

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As part of the national space promotion plan and presidential national agendas South Korea’s institutes and agencies under the auspices of the Ministry of Science, Information and Communication Technology and Future Planning (MSIP) are currently developing a lunar mission package expected to reach Moon in 2020. While the officially approved Korean Pathfinder Lunar Orbiter (KPLO) is aimed at demonstrating technologies and monitoring the lunar environment from orbit, a lander – currently in pre-phase A – is being designed to explore the local geology with a particular focus on the detection and characterization of mineral resources. In addition to scientific and potential resource potentials, the selection of the landing-site will be partly constrained by engineering constraints imposed by payload and spacecraft layout. Given today’s accumulated volume and quality of available data returned from the Moon’s surface and from orbital observations, an identification of landing sites of potential interest and assessment of potential hazards can be more readily accomplished by generating synoptic snapshots through data integration. In order to achieve such a view on potential landing sites, higher level processing and derivation of data are required, which integrates their spatial context, with detailed topographic and geologic characterizations. We are currently assessing the possibility of using fuzzy c-means clustering algorithms as a way to perform (semi-) automated terrain characterizations of interest. This paper provides information and background on the national lunar lander program, reviews existing approaches – including methods and tools – for landing site analysis and hazard assessment, and discusses concepts to detect and investigate elemental abundances from orbit and the surface. This is achieved by making use of manual, semi-automated as well as fully-automated remote-sensing methods to demonstrate the applicability of analyses. By considering given boundary conditions, concrete procedures for determining potential landing sites of the Korean lunar lander could be proposed.

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