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Journal articles on the topic 'MTA clinical applications'

Author: Grafiati

Published: 8 September 2021

Last updated: 29 July 2025

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1

Alshargawi, Waleed Khalid, Abeer Abdulaziz Alomari, Ali Obaid Alharbi, et al. "Clinical Applications of Mineral Trioxide Aggregate in Dental Procedures." JOURNAL OF HEALTHCARE SCIENCES 04, no. 12 (2024): 721–28. https://doi.org/10.52533/johs.2024.41212.

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Mineral Trioxide Aggregate (MTA) is a widely utilized material in modern dentistry, known for its exceptional biocompatibility, bioactivity, and versatility. Initially developed for root-end filling, its applications have expanded to include pulp therapy, root canal sealing, perforation repair, and regenerative endodontics. MTA’s bioactivity is attributed to its ability to release calcium ions upon hydration, promoting hydroxyapatite formation and creating an environment conducive to tissue regeneration. These properties, coupled with its excellent sealing ability and antibacterial activity, m

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Cervino, Gabriele, Luigi Laino, Cesare D’Amico, et al. "Mineral Trioxide Aggregate Applications in Endodontics: A Review." European Journal of Dentistry 14, no. 04 (2020): 683–91. http://dx.doi.org/10.1055/s-0040-1713073.

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AbstractA current topic in dentistry concerns the biocompatibility of the materials, and in particular, conservative dentistry and endodontics ones. The mineral trioxide aggregate (MTA) is a dental material with biocompatibility properties to oral and dental tissues. MTA was developed for dental root repair in endodontic treatment and it is formulated from commercial Portland cement, combined with bismuth oxide powder for radiopacity. MTA is used for creating apical plugs during apexification, repairing root perforations during root canal therapy, treating internal root resorption, and pulp ca

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Antonijevic, Djordje, Ana Despotovic, Dejan Cetkovic, Aleksandra Dozic, Ivana Milanovic, and Dragan Ilic. "Three case reports of different clinical applications of mineral trioxide aggregate." Stomatoloski glasnik Srbije 71, no. 1 (2024): 15–21. http://dx.doi.org/10.2298/sgs2401015a.

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Introduction. Calcium silicate dental cements have a wide range of applications in clinical dentistry. Many formulations were developed in the last decade and successfully employed for dental healing. In this paper, several clinical applications of mineral trioxide aggregate (MTA+, Cerkamed, Stalowa Wola, Poland) were presented. Outlines of cases. The first case report reflects the application of the MTA+ for the healing of the root perforation of the upper premolar. The second case report was the usage of MTA+ for indirect pulp capping in patient who came with pain of the tooth previously res

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E.Ç., Yunus, and Kürşat Er. "CLINICAL APPLICATIONS OF MINERAL TRIOXIDE AGGREGATE IN ENDODONTICS: A CASE SERIES." Scientific and practical journal Dentistry Kazakhstan, no. 3 (November 27, 2024): 4–14. http://dx.doi.org/10.70113/1815-9443.2024.61.69.001.

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In recent years, mineral trioxide aggregate (MTA) has been used extensively in endodontic treatment applications and satisfactory results have been obtained. This case series aims to describe the recovery of patients with the nonsurgical endodontic management of different endodontic cases using MTA. Case Report: Case 1. A 72-year-old female patient presented with cold and sweet sensitivity. A reversible pulpitis diagnosis was made, and direct pulp capping with MTA was performed. A 12-month follow-up showed positive clinical outcomes. Case 2. A 16-year-old female patient presented with prolonge

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Caliskan, Secil, Nuray Tuloglu, and Sule Bayrak. "Clinical applications of BioAggregate in pediatric dentistry: Case reports." Srpski arhiv za celokupno lekarstvo 147, no. 11-12 (2019): 746–50. http://dx.doi.org/10.2298/sarh190509124c.

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Introduction. Calcium-silicate-based, nanoparticle-sized BioAggregate is produced as an alternative version of mineral trioxide aggregate (MTA). It contains additives such as calcium phosphate and silicon dioxide but does not contain aluminium oxide and bismuth oxide. Studies have shown that BioAggregate?s calcium-ion release is better than these qualities in MTA concerning fracture and acid resistance, biocompatibility and sealing ability. Case outline. In this paper, we examine eight case reports. These reports describe the long-term results of using BioAggregate in areas such as pulpotomy a

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Rao, Arathi, Ashwini Rao, and Ramya Shenoy. "Mineral Trioxide Aggregate—A Review." Journal of Clinical Pediatric Dentistry 34, no. 1 (2009): 1–8. http://dx.doi.org/10.17796/jcpd.34.1.n1t0757815067g83.

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Mineral Trioxide Aggregate (MTA) is a new material with numerous exciting clinical applications. MTA promises to be one of the most versatile materials of this century in the field of dentistry. Some of the appreciable properties of MTA include its good physical properties and its ability to stimulate tissue regeneration as well as good pulp response. In this article the availability, composition, manipulation, setting reaction,properties and clinical applications of MTA in pediatric practice has been reviewed.

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Peycheva, Kalina. "Pulp-Capping with Mineral Trioxide Aggregate." Acta Medica Bulgarica 42, no. 2 (2015): 23–29. http://dx.doi.org/10.1515/amb-2015-0014.

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Summary There are two considerations for direct pulp capping - accidental mechanical pulp exposure and exposure caused by caries. Mineral trioxide aggregate (MTA) was used as pulp-capping material to preserve the vitality of the pulpal tissues. Follow-up examinations revealed that treatment was successful in preserving pulpal vitality and continued development of the tooth. On the basis of available information, it appears that MTA is the material of choice for some clinical applications. Material and methods: Cases 18 - 8 teeth with grey MTA, 10 teeth with white MTA; diagnose: Pulpitis chroni

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CLAUDER, THOMAS, and SU-JUNG SHIN. "Repair of perforations with MTA: clinical applications and mechanisms of action." Endodontic Topics 15, no. 1 (2006): 32–55. http://dx.doi.org/10.1111/j.1601-1546.2009.00242.x.

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9

Saeki, Katsura, Yuko Fujita, Yasuhiro Shiono, Yasuhiro Morimoto, and Kenshi Maki. "Pulp Revascularization in Immature Permanent Tooth with Apical Periodontitis Using Mineral Trioxide Aggregate." Case Reports in Medicine 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/564908.

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Mineral trioxide aggregate (MTA) is a material that has been used worldwide in several clinical applications, such as apical barriers in teeth with immature apices, repair of root perforations, root-end filling, pulp capping, and pulpotomy. The purpose of this case report was to describe successful revascularization treatment of an immature mandibular right second premolar with apical periodontitis in a 9-year-old female patient. After preparing an access cavity without anesthesia, the tooth was isolated using a rubber dam and accessed. The canal was gently debrided using 5% sodium hypochlorit

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Kim, Eui-Seong, and Su-Jung Shin. "Mineral Trioxide Aggregate (MTA): Review of its biologic properties." Journal of The Korean Dental Association 48, no. 11 (2010): 798–802. http://dx.doi.org/10.22974/jkda.2010.48.11.002.

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Introduction: MTA has been studied for more than 15 years since it was introduced and developed at Loma Linda University. The purpose of this review was to present the current published papers regarding MTA's biologic properties and to provide a deep insight into the material's mechanisms of actions. Results: MTA has appeared to be biocompatible in many previous researches. In addition to that, it had a potential to increase cell reactions such as proliferation and differentiation, Recently, MTA like new endodontic materials has been introduced and marketed. Conclusions: On the basis of curren

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Ahmed, Muthanna S., Nadia H. Hasan, and Mohammed G. Saeed. "Chemical analysis of mineral trioxide agregate mixed with hyaluronic acids as an accelerant." Brazilian Dental Journal 34, no. 6 (2023): 50–66. http://dx.doi.org/10.1590/0103-6440202305549.

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Abstract Mineral trioxide aggregate (MTA) has many clinical applications in dentistry; the main drawback is the long setting. The main objective is to investigate and compare the chemical effect of using two commercially available hyaluronic acid hydrogels (HA) instead of distilled water for mixing MTA as an accelerant of setting time. Materials and method: Test materials were divided into three groups; Group 1: (control) mixing MTA with distilled water supplied by the manufacturer; Group 2: mixing MTA with a hybrid cooperative complex of high and low molecular weight HA (Profhilo®); Group 3:

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Dr., Zakiyeh Donyavi Dr. Narges Heidari Dr. Elham Khoshbin Dr. Shahriar Shahriari Dr. Maryam Farhadian Dr. Rasoul Yousefi Mashouf Dr. Mohammad Esmaeilzadeh*. "ANTIBACTERIAL ACTIVITY OF MINERAL TRIOXIDE AGGREGATE, NEW ENDODONTIC CEMENT, RETRO MTA AND ORTHO MTA AGAINST COMMON ENDODONTIC PATHOGENS." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4720–28. https://doi.org/10.5281/zenodo.1087424.

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Introduction: Mineral trioxide aggregate [MTA] has extensive applications in endodontic treatment. Retro MTA, Ortho MTA and new endodontic cement [NEC] were also introduced to overcome the limitations of MTA. This study sought to compare the antibacterial activity of MTA, NEC, Ortho MTA and Retro MTA against common endodontic pathogens. Materials and Methods: This in vitro, experimental study was conducted on standard strains of Streptococcus mutans, Enterococcus faecalis, Actinomyces viscosus and Escherichia coli. Antibacterial activity of the materials was tested using the disc diffusion met

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SEIF, Heba, Ashraf M. ABU-SEIDA, Ahmed ELBANNA, and Dalia I. EL-KORASHY. "Physical properties and bioactivity of Aloe Vera modified tricalcium silicate-based cement." International Arab Journal of Dentistry 15, no. 1 (2024): 95–105. http://dx.doi.org/10.70174/iajd.v15i1.963.

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Objectives: This study compares the physical properties and bioactivity of tricalcium silicate-based cement (Matreva MTA) modified with various concentrations of Aloe vera (AV) solutions and Bio dentine cement. Methods: Sixty discs were prepared, and divided into 5 groups (12 discs each) based on the es timated materials: group I: Biodentine, group II: Matreva MTA, group III: Matreva MTA with 10% AV, group IV: Matreva MTA with 20% AV and group V: Matreva MTA with 30% AV. The flow and setting time were assessed following ISO standard 6876:2012 and American Society for Testing and Materials (AST

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Srivastava, Ruchi, Anju Gautam, and Pushpendra Kumar Verma. "Interdisciplinary management of horizontal root fracture in middle third with osseous bone defect – A clinical report." IP International Journal of Periodontology and Implantology 8, no. 4 (2023): 222–24. http://dx.doi.org/10.18231/j.ijpi.2023.042.

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Dental trauma are the main cause of emergencies in dental practice. Amongst these, root fractures are relatively uncommon but comprises about 0.5 to 7% of all injuries affecting permanent dentition. Most commonly, root fracture occurs from a horizontal impact mostly in oblique direction. The incidence is more common at the mid-third of the root rather at the apical and cervical thirds. Such hideous injury must be restored to normal as early as possible to retain the dental health and appearance. This report records the case of horizontal root fracture of upper anterior tooth, treated with Mine

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Dong, Xu, and Xin Xu. "Bioceramics in Endodontics: Updates and Future Perspectives." Bioengineering 10, no. 3 (2023): 354. http://dx.doi.org/10.3390/bioengineering10030354.

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Bioceramics, with excellent bioactivity and biocompatibility, have been widely used in dentistry, particularly in endodontics. Mineral trioxide aggregate (MTA) is the most widely used bioceramic in endodontics. Recently, many new bioceramics have been developed, showing good potential for the treatment of endodontic diseases. This paper reviews the characteristics of bioceramics and their applications in various clinical endodontic situations, including root-end filling, root canal therapy, vital pulp therapy, apexification/regenerative endodontic treatment, perforation repair, and root defect

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Jiang, Yuqing, Qinghua Zheng, Xuedong Zhou, Yuan Gao, and Dingming Huang. "A Comparative Study on Root Canal Repair Materials: A Cytocompatibility Assessment in L929 and MG63 Cells." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/463826.

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Cytocompatibility of repair materials plays a significant role in the success of root canal repair. We conducted a comparative study on the cytocompatibility among iRoot BP Plus, iRoot FS, ProRoot MTA, and Super-EBA in L929 cells and MG63 cells. The results revealed that iRoot FS was able to completely solidify within 1 hour. iRoot BP Plus required 7-day incubation, which was much longer than expected (2 hours), to completely set. ProRoot MTA and Super-EBA exhibited a similar setting duration of 12 hours. All the materials except Super-EBA possessed negligiblein vitrocytotoxicity. iRoot FS had

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Najmi, Muhammad Arqam, Talha Nayab, Beenish Fatima Alam, et al. "Role of mineral trioxide aggregate in dentistry: A bibliometric analysis using Scopus database." Journal of Applied Biomaterials & Functional Materials 21 (January 2023): 228080002311540. http://dx.doi.org/10.1177/22808000231154065.

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Objectives: Mineral trioxide aggregate (MTA) has a long history of providing predictable clinical outcomes in dental applications especially in endodontic procedures. This bibliometric analysis aimed at evaluating the advancements of research in mineral trioxide aggregate and its use in the field of dentistry, together with the detection of most significant authors, organizations, countries, journals, papers, and the exploration of commonly used keywords using a structured approach. Materials and method: The search was conducted using the Elsevier’s Scopus database, gathering publication infor

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Ballal, Nidambur Vasudev, Sheetal Rao, Nirmala Rao, et al. "Evaluation of Two Different Types of Mineral Trioxide Aggregate Cements as Direct Pulp Capping Agents in Human Teeth." Applied Sciences 11, no. 21 (2021): 10455. http://dx.doi.org/10.3390/app112110455.

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Traumatic human dental injuries involving the pulp might necessitate direct capping procedures. This clinical study aimed to analyse the histological outcomes using two different direct capping materials. Twenty patients with bilateral premolars, scheduled for orthodontic extraction, were selected. The teeth were treated either using ProRoot MTA or RetroMTA. All patients were recalled after 30 and 60 days for teeth extraction. The histopathologically stained specimens were blindly evaluated using hard tissue bridge formation, inflammatory reaction and pulpal findings criteria. Data were evalua

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Donfrancesco, Orlando, Alessio Zanza, Rodolfo Reda, Luca Testarelli, Michela Relucenti, and Marco Seracchiani. "Comparative Evaluation of Marginal Adaptation and Dimensional Stability of Three Bioceramic Root Repair Materials: A VP-SEM Analysis." Journal of Composites Science 8, no. 8 (2024): 294. http://dx.doi.org/10.3390/jcs8080294.

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This study investigated the marginal adaptation of three recently introduced bioceramic root repair materials, EdgeBioCeramic RetroFill, Endocem MTA, and One-Fil PT, using VP-SEM analysis. Extracted single-rooted lower incisors were used to simulate retrograde fillings. The results showed no statistically significant differences in the marginal gap between the materials and the dentin walls. All three materials exhibited good dimensional stability, with gap sizes comparable to previously published research on similar materials. The mean GAP was 3.91 ± 2.56 for EdgeBioCeramic RetroFill, 4.32 ±

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Noites, Rita, Inês Tavares, Miguel Cardoso, et al. "Human Gingival Fibroblasts Response to Different Endodontic Sealers: An In Vitro Study." Applied Sciences 13, no. 19 (2023): 10976. http://dx.doi.org/10.3390/app131910976.

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Endodontic treatment aims to eliminate infection of the root canals and fill the dental pulp space. The biocompatibility studies of the sealers used in root canals obturation are crucial since they are applied in direct contact with periradicular tissues. Objective: The aim of this study was to evaluate the cytotoxicity of three root canal sealers—AH Plus, Bio MTA+, and Bio C sealer—on immortalized human gingival fibroblasts. Methods: AH Plus, Bio MTA+, and Bio C sealers were evaluated through incubation in real-time and material-conditioned media. Cells were incubated for 24 h and 72 h, at th

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Muruganandhan, Jayanandan, Govindarajan Sujatha, Saravanan Poorni, et al. "Comparison of Four Dental Pulp-Capping Agents by Cone-Beam Computed Tomography and Histological Techniques—A Split-Mouth Design Ex Vivo Study." Applied Sciences 11, no. 7 (2021): 3045. http://dx.doi.org/10.3390/app11073045.

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Dental pulp-capping is done to preserve vital teeth when the pulp is exposed due to caries, trauma or instrumentation. Various materials are used as pulp-capping agents. The introduction of newer materials requires scientific studies to assess their clinical efficacy. The study was designed as a split-mouth randomized analysis of four pulp-capping agents (calcium hydroxide, mineral trioxide aggregate (MTA), Biodentine and EndoSequence root repair material (ERRM)). Based on selection criteria, 15 orthodontic patients requiring the extraction of four premolars (60 teeth total) were included in t

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Barczak, Katarzyna, Mirona Palczewska-Komsa, Mariusz Lipski, Dariusz Chlubek, Jadwiga Buczkowska-Radlińska, and Irena Baranowska-Bosiacka. "The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages." International Journal of Molecular Sciences 22, no. 1 (2020): 295. http://dx.doi.org/10.3390/ijms22010295.

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The aim of the present study was to investigate the new silicate cement mineral trioxide aggregate (MTA Repair HP) with respect to its effect on the inflammation process involving the tooth and periodontal tissues. The composition of MTA Repair HP was supplemented with plasticizer agents which can have a negative effect on the modulation of tooth inflammation. The silicate-based material in question is widely used in regeneration of the pulp-dentin complex, treatment of perforations of various locations in the tooth, as well as in surgical treatment of the complications of periapical tissue. T

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Paulo, Cristina Rodrigues, Joana A. Marques, Diana B. Sequeira, et al. "Influence of Blood Contamination on Push-Out Bond Strength of Three Calcium Silicate-Based Materials to Root Dentin." Applied Sciences 11, no. 15 (2021): 6849. http://dx.doi.org/10.3390/app11156849.

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A proper bond between root canal filling materials and dentin surface is essential to resist dislodgement and guarantee long-term success. Blood exposure is likely to occur in various clinical situations in which calcium silicate-based materials are used; therefore, it is fundamental to render data concerning the influence of blood on bond strength. The present study aims to evaluate the effect of blood contamination on the push-out bond strength obtained with three different biomaterials to root canal dentin; Ninety extracted human mono-radicular permanent teeth were selected. The root canals

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Priyadharshini, S. Swathi, Chinnasamy Ragavendran, I. Anand Sherwood, and Ramanaramya Jeyapalan. "Comparative evaluation of compressive strength and morphological interface of carbonated hydroxyapatite with other pulp capping materials: An in vitro analysis." Endodontology 37, no. 1 (2025): 90–95. https://doi.org/10.4103/endo.endo_92_24.

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Aim: The aim of this study was to evaluate and compare the compressive strength of carbonated hydroxyapatite (CHA) to other pulp capping materials and to assess the morphological interface of CHA when immediately restored with final restorative material. Methods: CHA was synthesized and subsequently subjected to characterization. To evaluate compressive strength, samples were prepared in stainless steel molds and then divided into two groups for testing: immediate and after 24 h of incubation. They were subsequently subjected to compressive strength testing using an INSTRON universal testing m

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Kouzmanova, Yaneta, and Ivanka Dimitrova. "Marginal Adaptation and Porosity of a Novel MTA Brand Applied as Root-End Filling Material: A Micro-CT Study." Applied Sciences 14, no. 7 (2024): 2758. http://dx.doi.org/10.3390/app14072758.

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Marginal adaptation and internal porosity characteristics of root-end filling materials are important factors determining their clinical performance. The aim of this study was to quantitatively evaluate the marginal adaptation to radicular dentin (interfacial void volume) and internal porosity volume of a novel mineral trioxide aggregate brand using micro-CT analysis. Ten extracted upper central incisors were selected, instrumented, and obturated. Roots were resected at the apical 3 mm, and root-end cavities were prepared ultrasonically and filled with Harvard MTA. SkyScan 1272 micro-CT equipm

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Mangesius, Stephanie, Lukas Haider, Lukas Lenhart, et al. "Qualitative and Quantitative Comparison of Hippocampal Volumetric Software Applications: Do All Roads Lead to Rome?" Biomedicines 10, no. 2 (2022): 432. http://dx.doi.org/10.3390/biomedicines10020432.

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Brain volumetric software is increasingly suggested for clinical routine. The present study quantifies the agreement across different software applications. Ten cases with and ten gender- and age-adjusted healthy controls without hippocampal atrophy (median age: 70; 25–75% range: 64–77 years and 74; 66–78 years) were retrospectively selected from a previously published cohort of Alzheimer’s dementia patients and normal ageing controls. Hippocampal volumes were computed based on 3 Tesla T1-MPRAGE-sequences with FreeSurfer (FS), Statistical-Parametric-Mapping (SPM; Neuromorphometrics and Hammers

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Li, Zhen, Tian Wang, Lan Yun, Xiaomin Ren, Yong Wang, and Fengling Shi. "Association Analysis of Tiller-Related Traits with EST-SSR Markers in Psathyrostachys juncea." Genes 14, no. 10 (2023): 1970. http://dx.doi.org/10.3390/genes14101970.

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Psathyrostachys juncea is a long-lived perennial Gramineae grass with dense basal tillers and soft leaves. It is used widely in cold and dry areas of Eurasia and North America to establish grazing pasture and is even used as an ideal plant for revegetation and ecological restoration. Plant architecture, especially tillering traits, is critical for bunch grasses in breeding programs, and these traits in plants are mostly quantitative traits. In this study, the genetic diversity, population structure, and linkage disequilibrium of 480 individual lines were analyzed using 127 pairs of the EST-SSR

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Yu, Lintong, Yijie Zhou, Jiahui Li, Jing Cheng, and Guangtai Song. "Revascularization of an Immature Permanent Tooth with Periapical Periodontitis Using Concentrated Growth Factor Assisted by Erbium Laser (2940 nm) Irrigation: A Case Report." Applied Sciences 12, no. 9 (2022): 4751. http://dx.doi.org/10.3390/app12094751.

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Revascularization has been incorporated into endodontic practice and become a viable treatment alternative for immature teeth with pulp necrosis. Thorough disinfection of the root canal is a key factor for successful revascularization. An erbium: yttrium–aluminium–garnet (Er: YAG) laser has been proved advantageous for efficient root canal disinfection. This article reports one case of periapical periodontitis caused by a fractured occlusal tubercle. Revascularization assisted by Er: YAG laser irrigation was carried out with long-term follow up. During the process of treatment, we opened drain

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Wolff, Steven. "Clinical Applications of Carotid and Thoracic MRA." Journal of Vascular and Interventional Radiology 14, no. 2 (2003): P197. http://dx.doi.org/10.1016/s1051-0443(03)70175-4.

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Prince, Martin R. "Clinical Applications of Renal and Mesenteric MRA." Journal of Vascular and Interventional Radiology 14, no. 2 (2003): P198. http://dx.doi.org/10.1016/s1051-0443(03)70176-6.

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Stein, Barry. "Clinical Applications of Peripheral Lower Extremity MRA." Journal of Vascular and Interventional Radiology 14, no. 2 (2003): P198—P200. http://dx.doi.org/10.1016/s1051-0443(03)70177-8.

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Yang, Qi, Kuncheng Li, and Debiao Li. "Coronary MRA: Technical Advances and Clinical Applications." Current Cardiovascular Imaging Reports 4, no. 2 (2011): 165–70. http://dx.doi.org/10.1007/s12410-010-9064-2.

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Solmos, Susan, Amit Gefen, Joyce Black, Aleksei Orlov, Orel Belo, and Janet Cuddigan. "Medical Device Testing: Methods, Significance, and Clinical Applications." Advances in Skin & Wound Care 36, no. 10 (2023): 513–22. http://dx.doi.org/10.1097/asw.0000000000000037.

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ABSTRACT GENERAL PURPOSE To present a study conducting objective biomechanical testing of medical devices known to cause medical device-related pressure injuries (MDRPIs) in critically ill adults and comparing those results with clinical outcomes associated with each device. TARGET AUDIENCE This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES After participating in this educational activity, the participant will: 1. Explain the results of the study of the relati

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Shapiro, David A. "Recent applications of meta-analysis in clinical research." Clinical Psychology Review 5, no. 1 (1985): 13–34. http://dx.doi.org/10.1016/0272-7358(85)90027-3.

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Dormion, Gaëlle, Hélène Bonneau-Chloup, and Mathieu Dellenbach. "State of the art on clinical and biological applications of Artificial Intelligence to Fertility." Médecine de la Reproduction 27, no. 1 (2025): 41–55. https://doi.org/10.1684/mte.2025.1041.

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Sugita, Yoshihiko, Takahisa Okubo, Makiko Saita, et al. "Novel Osteogenic Behaviors around Hydrophilic and Radical-Free 4-META/MMA-TBB: Implications of an Osseointegrating Bone Cement." International Journal of Molecular Sciences 21, no. 7 (2020): 2405. http://dx.doi.org/10.3390/ijms21072405.

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Poly(methyl methacrylate) (PMMA)-based bone cement, which is widely used to affix orthopedic metallic implants, is considered bio-tolerant but lacks osteoconductivity and is cytotoxic. Implant loosening and toxic complications are significant and recognized problems. Here we devised two strategies to improve PMMA-based bone cement: (1) adding 4-methacryloyloxylethyl trimellitate anhydride (4-META) to MMA monomer to render it hydrophilic; and (2) using tri-n-butyl borane (TBB) as a polymerization initiator instead of benzoyl peroxide (BPO) to reduce free radical production. Rat bone marrow-deri

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Al-Radaideh, Ahmad Tawfig. "Factors affecting acceptance and adoption of mobile health application (MHA)." International Journal of Psychosocial Rehabilitation 24, no. 04 (2020): 1218–29. http://dx.doi.org/10.37200/ijpr/v24i4/pr201093.

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Holcomb, Bryan, Michele Yip-Schneider та C. Max Schmidt. "The Role of Nuclear Factor κB in Pancreatic Cancer and the Clinical Applications of Targeted Therapy". Pancreas 36, № 3 (2008): 225–35. http://dx.doi.org/10.1097/mpa.0b013e31815b3207.

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Ma, Mingyang, Tong Ye, Jiewei Wang, et al. "N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer." Diagnostics 12, no. 12 (2022): 2996. http://dx.doi.org/10.3390/diagnostics12122996.

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N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and

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Ang, Huiying, Jinjie Lin, Ying Ying Huang, et al. "Drug-Coated Balloons: Technologies and Clinical Applications." Current Pharmaceutical Design 24, no. 4 (2018): 381–96. http://dx.doi.org/10.2174/1381612824666171227221305.

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The progress and development of drug-coated balloons (DCBs) represents an emerging alternative treatment in peripheral and coronary artery diseases, particularly when a non-stent approach is necessary. Several studies and meta-analyses have evaluated the clinical outcomes of DCBs in different lesions and this review aims to compile the progress and updated clinical data of DCB strategy in both peripheral artery diseases (PAD) and coronary artery diseases (CAD). The review highlights that clinical data has encouraged the use of DCB for applications in PAD and in the treatment of coronary in-ste

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Alfimov, A. E., D. Y. Alekseeva, D. O. Korolev, D. M. Gorinova, M. E. Yenikeev, and L. M. Rapoport. "Clinical Applications of the Markers of Lithogenic Activity in Kidney Stone Disease." Andrology and Genital Surgery 25, no. 1 (2024): 24–30. http://dx.doi.org/10.62968/2070-9781-2024-25-1-24-30.

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Markers of lithogenic activity (MLA) – are the lab or instrumental tests, indicating the intensity of stone-forming pathologic process. We have described six groups of such markers in our previous review. Here we review the various clinical applications of these diagnostic tests mentioned by their authors. We emphasize the importance of the following MLA clinical applications: 1) revealing the periods of high lithogenic activity, 2) control of metaphylaxis efficacy. As long as these clinical applications require regular and sometimes frequent testing, the tests need to be adopted for the home

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Huynh, Mylene T., Dawn Marie Christerson, and Stephen J. Sharp. "Ten Clinical Applications from the 8th International Auriculotherapy Symposium for the Treatment of Wounded Warriors." Medical Acupuncture 27, no. 4 (2015): 242–45. http://dx.doi.org/10.1089/acu.2015.29003.mth.

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Kong, Dede. "The Role of N6-Methyladenosine RNA Methylation in Cardiovascular Diseases: Molecular Mechanisms and Clinical Applications." Theoretical and Natural Science 93, no. 1 (2025): 68–74. https://doi.org/10.54254/2753-8818/2025.22367.

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Cardiovascular diseases (CVDs), the leading cause of global mortality, demand novel therapeutic strategies targeting their molecular underpinnings. Emerging research underscores N6-methyladenosine (m6A) RNA methylationa dynamic epigenetic modification orchestrated by writers (e.g., METTL3), erasers (e.g., FTO), and readers (e.g., YTHDF)as a central regulator of CVD pathogenesis. By modulating RNA splicing, stability, and translation, m6A critically influences inflammation, fibrosis, and metabolic homeostasis. The dysregulation of this machinery drives pathologies such as atherosclerosis, where

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Kaptur, Agata, Dawid Dziedziński, Dawid Łoś, Aleksandra Nowak, Anita Janus, and Oliwia Kwaśniewska. "Clinical applications of ketamine: a literature review." Quality in Sport 18 (August 15, 2024): 53759. http://dx.doi.org/10.12775/qs.2024.18.53759.

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Ketamine, initially recognized for its anesthetic capabilities, has emerged as a multifaceted pharmacological intervention with applications extending beyond the surgical setting. This literature review explores the diverse clinical applications of ketamine, delving into its well-established role in anesthesiology and its burgeoning potential in the psychiatric domain. The review discusses ketamine's mechanism of action, emphasizing its unique profile as an NMDA receptor antagonist. Its rapid-acting antidepressant and anti-suicidal effects are highlighted, along with its efficacy in treating c

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Standley, J. M. "Music Research in Medical/Dental Treatment: Meta-Analysis and Clinical Applications." Journal of Music Therapy 23, no. 2 (1986): 56–122. http://dx.doi.org/10.1093/jmt/23.2.56.

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Gu, Chang, Xin Shi, Chenyang Dai, et al. "RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications." Innovation 1, no. 3 (2020): 100066. http://dx.doi.org/10.1016/j.xinn.2020.100066.

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Ow, Andrew T. C., and Lim K. Cheung. "Meta-Analysis of Mandibular Distraction Osteogenesis: Clinical Applications and Functional Outcomes." Plastic and Reconstructive Surgery 121, no. 3 (2008): 54e—69e. http://dx.doi.org/10.1097/01.prs.0000299285.97379.35.

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Appunni, Sandeep, Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Peter McGranaghan, and Emir Veledar. "Stroke Genomics: Current Knowledge, Clinical Applications and Future Possibilities." Brain Sciences 12, no. 3 (2022): 302. http://dx.doi.org/10.3390/brainsci12030302.

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The pathophysiology of stoke involves many complex pathways and risk factors. Though there are several ongoing studies on stroke, treatment options are limited, and the prevalence of stroke is continuing to increase. Understanding the genomic variants and biological pathways associated with stroke could offer novel therapeutic alternatives in terms of drug targets and receptor modulations for newer treatment methods. It is challenging to identify individual causative mutations in a single gene because many alleles are responsible for minor effects. Therefore, multiple factorial analyses using

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Ingraldi, Alison L., Tim Allen, Joseph N. Tinghitella, William C. Merritt, Timothy Becker, and Aaron J. Tabor. "Characterization of Amnion-Derived Membrane for Clinical Wound Applications." Bioengineering 11, no. 10 (2024): 953. http://dx.doi.org/10.3390/bioengineering11100953.

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Human amniotic membrane (hAM), the innermost placental layer, has unique properties that allow for a multitude of clinical applications. It is a common misconception that birth-derived tissue products, such as dual-layered dehydrated amnion–amnion graft (dHAAM), are similar regardless of the manufacturing steps. A commercial dHAAM product, Axolotl Biologix DualGraft™, was assessed for biological and mechanical characteristics. Testing of dHAAM included antimicrobial, cellular biocompatibility, proteomics analysis, suture strength, and tensile, shear, and compressive modulus testing. Results de

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Ahmad, Sharique, Priyesh Srivastava, Mohd Ibrahim, Beenish Bano, Mehnaz Khan, and Faraz Shamim. "Meta-Analysis of Transfection." Scholars International Journal of Traditional and Complementary Medicine 8, no. 01 (2025): 14–19. https://doi.org/10.36348/sijtcm.2025.v08i01.003.

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Transfection is a critical technique for introducing nucleic acids—such as DNA, RNA, or oligonucleotides—into cells and plays a pivotal role in diverse research fields, including gene therapy, recombinant protein production, and functional genomics. This meta-analysis examines the fundamental mechanisms, methodologies, and challenges associated with transfection, highlighting advances in both viral and non-viral delivery systems, optimization techniques, and clinical applications. Viral vectors, including adenovirus, retrovirus, and lentivirus, offer high efficiency and are frequently used in

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