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Relevant bibliographies by topics / MtDNA segregation

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Journal articles

Academic literature on the topic 'MtDNA segregation'

Author: Grafiati

Published: 31 August 2024

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Journal articles on the topic "MtDNA segregation"

1

Takeda, Kumiko, Seiya Takahashi, Akira Onishi, Hirofumi Hanada, and Hiroshi Imai. "Replicative Advantage and Tissue-Specific Segregation of RR Mitochondrial DNA Between C57BL/6 and RR Heteroplasmic Mice." Genetics 155, no. 2 (2000): 777–83. http://dx.doi.org/10.1093/genetics/155.2.777.

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Abstract To investigate the interactions between mtDNA and nuclear genomes, we produced heteroplasmic maternal lineages by transferring the cytoplasts between the embryos of two mouse strains, C57BL/6 (B6) and RR. A total of 43 different nucleotides exist in the displacement-loop (D-loop) region of mtDNA between B6 and RR. Heteroplasmic embryos were reconstructed by electrofusion using a blastomere from a two-cell stage embryo of one strain and an enucleated blastomere from a two-cell stage embryo of the other strain. Equivalent volumes of both types of mtDNAs were detected in blastocyst stage

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2

Lechuga-Vieco, Ana Victoria, Ana Latorre-Pellicer, Iain G. Johnston, et al. "Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics." Science Advances 6, no. 31 (2020): eaba5345. http://dx.doi.org/10.1126/sciadv.aba5345.

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Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specific mtDNA segregation pattern, with few tissues that do not show segregation. The driving force for this dynamic complex pattern has remained unexplained for decades, challenging our understanding of this fundamental biological problem and hindering clinical planning for inherited diseases. Here, we d

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3

Røyrvik, Ellen C., and Iain G. Johnston. "MtDNA sequence features associated with ‘selfish genomes’ predict tissue-specific segregation and reversion." Nucleic Acids Research 48, no. 15 (2020): 8290–301. http://dx.doi.org/10.1093/nar/gkaa622.

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Abstract Mitochondrial DNA (mtDNA) encodes cellular machinery vital for cell and organism survival. Mutations, genetic manipulation, and gene therapies may produce cells where different types of mtDNA coexist in admixed populations. In these admixtures, one mtDNA type is often observed to proliferate over another, with different types dominating in different tissues. This ‘segregation bias’ is a long-standing biological mystery that may pose challenges to modern mtDNA disease therapies, leading to substantial recent attention in biological and medical circles. Here, we show how an mtDNA sequen

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4

Tsang, William Y., and Bernard D. Lemire. "Stable heteroplasmy but differential inheritance of a large mitochondrial DNA deletion in nematodes." Biochemistry and Cell Biology 80, no. 5 (2002): 645–54. http://dx.doi.org/10.1139/o02-135.

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Many human mitochondrial diseases are associated with defects in the mitochondrial DNA (mtDNA). Mutated and wild-type forms of mtDNA often coexist in the same cell in a state called heteroplasmy. Here, we report the isolation of a Caenorhabditis elegans strain bearing the 3.1-kb uaDf5 deletion that removes 11 genes from the mtDNA. The uaDf5 deletion is maternally transmitted and has been maintained for at least 100 generations in a stable heteroplasmic state in which it accounts for ~60% of the mtDNA content of each developmental stage. Heteroplasmy levels vary between individual animals (from

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5

Ling, Feng, Rong Niu, Hideyuki Hatakeyama, Yu-ichi Goto, Takehiko Shibata, and Minoru Yoshida. "Reactive oxygen species stimulate mitochondrial allele segregation toward homoplasmy in human cells." Molecular Biology of the Cell 27, no. 10 (2016): 1684–93. http://dx.doi.org/10.1091/mbc.e15-10-0690.

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Mitochondria that contain a mixture of mutant and wild-type mitochondrial (mt) DNA copies are heteroplasmic. In humans, homoplasmy is restored during early oogenesis and reprogramming of somatic cells, but the mechanism of mt-allele segregation remains unknown. In budding yeast, homoplasmy is restored by head-to-tail concatemer formation in mother cells by reactive oxygen species (ROS)–induced rolling-circle replication and selective transmission of concatemers to daughter cells, but this mechanism is not obvious in higher eukaryotes. Here, using heteroplasmic m.3243A > G primary fibroblast

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6

Zelenaya-Troitskaya, Olga, Scott M. Newman, Koji Okamoto, Philip S. Perlman, and Ronald A. Butow. "Functions of the High Mobility Group Protein, Abf2p, in Mitochondrial DNA Segregation, Recombination and Copy Number in Saccharomyces cerevisiae." Genetics 148, no. 4 (1998): 1763–76. http://dx.doi.org/10.1093/genetics/148.4.1763.

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Abstract Previous studies have established that the mitochondrial high mobility group (HMG) protein, Abf2p, of Saccharomyces cerevisiae influences the stability of wild-type (ρ+) mitochondrial DNA (mtDNA) and plays an important role in mtDNA organization. Here we report new functions for Abf2p in mtDNA transactions. We find that in homozygous Δabf2 crosses, the pattern of sorting of mtDNA and mitochondrial matrix protein is altered, and mtDNA recombination is suppressed relative to homozygous ABF2 crosses. Although Abf 2p is known to be required for the maintenance of mtDNA in ρ+ cells growing

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7

Okamoto, Koji, Philip S. Perlman, and Ronald A. Butow. "The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud." Journal of Cell Biology 142, no. 3 (1998): 613–23. http://dx.doi.org/10.1083/jcb.142.3.613.

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Green fluorescent protein (GFP) was used to tag proteins of the mitochondrial matrix, inner, and outer membranes to examine their sorting patterns relative to mtDNA in zygotes of synchronously mated yeast cells in ρ+ × ρ0 crosses. When transiently expressed in one of the haploid parents, each of the marker proteins distributes throughout the fused mitochondrial reticulum of the zygote before equilibration of mtDNA, although the membrane markers equilibrate slower than the matrix marker. A GFP-tagged form of Abf2p, a mtDNA binding protein required for faithful transmission of ρ+ mtDNA in vegeta

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8

Meirelles, Flávio V., and Lawrence C. Smith. "Mitochondrial Genotype Segregation in a Mouse Heteroplasmic Lineage Produced by Embryonic Karyoplast Transplantation." Genetics 145, no. 2 (1997): 445–51. http://dx.doi.org/10.1093/genetics/145.2.445.

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Mitochondrial genotypes have been shown to segregate both rapidly and slowly when transmitted to consecutive generations in mammals. Our objective was to develop an animal model to analyze the patterns of mammalian mitochondrial DNA (mtDNA) segregation and transmission in an intraspecific heteroplasmic maternal lineage to investigate the mechanisms controlling these phenomena. Heteroplasmic progeny were obtained from reconstructed blastocysts derived by transplantation of pronuclear-stage karyoplasts to enucleated zygotes with different mtDNA. Although the reconstructed zygotes contained on av

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9

Clark, A. G., and E. M. Lyckegaard. "Natural selection with nuclear and cytoplasmic transmission. III. Joint analysis of segregation and mtDNA in Drosophila melanogaster." Genetics 118, no. 3 (1988): 471–81. http://dx.doi.org/10.1093/genetics/118.3.471.

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Abstract Despite the widespread use of mitochondrial DNA by evolutionary geneticists, relatively little effort has been spent assessing the magnitude of forces maintaining mtDNA sequence diversity. In this study the influence of cytoplasmic variation on viability in Drosophila was examined by analysis of second chromosome segregation. A factorial experiment with balancer chromosomes permitted the effects of cytoplasma and reciprocal crosses to be individually distinguished. The first test used six lines of diverse geographic origin, testing the segregation of all six second chromosomes in all

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10

Smith, Lawrence C., Jacob Thundathil, and France Filion. "Role of the mitochondrial genome in preimplantation development and assisted reproductive technologies." Reproduction, Fertility and Development 17, no. 2 (2005): 15. http://dx.doi.org/10.1071/rd04084.

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Our fascination for mitochondria relates to their origin as symbiotic, semi-independent organisms on which we, as eukaryotic beings, rely nearly exclusively to produce energy for every cell function. Therefore, it is not surprising that these organelles play an essential role in many events during early development and in artificial reproductive technologies (ARTs) applied to humans and domestic animals. However, much needs to be learned about the interactions between the nucleus and the mitochondrial genome (mtDNA), particularly with respect to the control of transcription, replication and se

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