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Sayin, Huseyin. "Tactical Messaging And Usage Of Extensible Markup Language Message Text Formats In The Tactical Command Control And Information Systems." Master's thesis, METU, 2003. http://etd.lib.metu.edu.tr/upload/1224682/index.pdf.
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This thesis investigates the usage area of Extensible Markup Language Message Text Format (XML-MTF) in Tactical Command and Control Information System (TC2IS). It examines the used tactical message types and their application area in Turkish Army and what the XML and XML-MTFs are explained. FinallyMTF traffic of a brigade is simulated to verify that XML technology can be used effectively in Turkish Land Forces Tactical Command Control and Information System Projects (TLF TC2IS).
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Falco, Tony. "MTF, NPS and DQE analysis of portal metal-platefilm detectors." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23885.
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Previous studies of modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) of metal-plate/film portal detectors have been performed on limited combinations of front and back metal-plates. We report on these parameters for an extensive set of forty-nine front-back metal-plate combinations. The portal detector consists of a double emulsion RP (Kodak localization therapy) film placed between metal-plates: Al, Cu, brass and Pb of thicknesses varying from 0.30 to 4.80 mm. Radiation sources included a Theratron Co-60 unit, and a Varian Clinac-18 linear accelerator delivering a polyenergetic 10 MV X-ray spectrum. In terms of the absolute efficiency of the detectors, the best DQE is obtained with the detector consisting of a 1.75 mm Cu front plate and a 1.62 mm Al back plate for the Clinac-18, and with the detector consisting of a 0.95 mm Cu front plate and a 0.80 mm Cu or a 1.62 mm Al back plate for the Co-60 gamma ray source.
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Macalanda, Eduardo C. "Radio frequency identification (RFID) for Naval Medical Treatment Facilities (MTF)." Thesis, Monterey, California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2578.
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The application of Radio Frequency Identification (RFID) technology in hospitals is modest primarily due to cost and policy issues. Similar to the evolution of other electronic technologies, unit costs for components have been dramatically reduced in the past few years. Despite the reduction in costs, RFID technology has not yet achieved the tipping point of economic rationality for adoption at most healthcare organizations. Although the technology has been primarily applied to asset management and supply chain applications, Navy Medicine stands to gain tremendous benefit if this technology could be successfully implemented for staff and patient tracking in addition to inventory management. The purpose of this thesis was to conduct a review of RFID technology and components that could fit into the Navy Medicine's structure. The study explored the implementation requirements associated with the deployment in other industries that could be used as benchmarks for Navy Medicine implementation. Different technological architectures were described to illustrate the various techniques that could be used for creating the opportunity to automate administration, reduce errors and improve security for both patients and staff.
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Silva, Fernanda Amorim Gomes da. "Avaliação temporal e espacial da expressão das metaloproteinases de matriz tipo de membrana (MT2, MT3, MT4, MT5 e MT6-MMP) durante a ossificação endocondral em camundongos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-09112010-105227/.
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As MMPs são endopeptidases zinco dependentes que, em conjunto, podem degradar todos os componentes da MEC e gerar moléculas bioativas. São as principais responsáveis pelo remodelamento tecidual durante eventos fisiológicos normais como a embriogênese e organogênese e também em eventos patológicos como a invasão tumoral nos tecidos. As pesquisas na área de mineralização biológica têm buscado identificar os genes envolvidos nos mecanismos moleculares que regula o processo de ossificação endocondral. As MMPs e seus inibidores são responsáveis pelo controle da degradação desta matriz, como os inibidores teciduais das MMPs (TIMPs) e a proteína RECK, que, muito provavelmente, determinam o grau de remodelação da matriz extracelular. Desta forma, nosso objetivo foi delinear o perfil temporal e espacial da expressão das MMP-15/MT2-MMP, MMP-16/MT3- MMP, MMP-17/MT4-MMP, MMP-24/MT5-MMP e MMP-25/MT6-MMP durante a ossificação endocondral em embriões de camundongos e em animais recémnascidos através das técnicas de PCR em tempo real e imunohistoquímica. Por imunohistoquímica, nós não encontramos imunomarcação para a MMP-15/MT2- MMP em nenhum dos períodos analisados, apesar da padronização do anticorpo primário. Tanto a MMP-16/MT3-MMP quanto a MMP-24/MT5-MMP foram imunolocalizadas, principalmente, nos osteoblastos do fronte de ossificação da placa de crescimento. Para a MMP-17/MT4-MMP, durante a diferenciação condrocítica (E13) os condrócitos proliferativos foram imunocorados, bem como os condrócitos hipertróficos no centro da cartilagem do molde cartilaginoso (E14). Durante a invasão celular e vascular (E15), as células mesenquimais oriundas do colar ósseo, provavelmente pré-osteoblastos, foram imunocorados na cavidade medular primitiva e osteoblastos fronte de ossificação foram imunocorados, de E16 a PN1. Observamos para a MMP-25/MT6-MMP o mesmo padrão de imunomarcação das demais MT-MMPs, exceto no molde cartilaginoso, onde apenas as células do periósteo e pericôndrio foram imunocoradas, diferentemente da demais que foram localizadas apenas no centro do molde cartilaginoso. A análise da expressão dos transcritos para todas as MT-MMPs revelou o mesmo perfil de expressão, sendo alta durante a fase de diferenciação condrocítica (E13), tendo queda de expressão de E14 a E16. Em E16 há um aumento de expressão até E18 e, novamente, queda até E20 e pouca ou nenhuma expressão em PN7. Apesar deste perfil semelhante, houve uma expressão diferencial entre elas, sendo a MMP-15/MT2-MMP > MMP- 17/MT4-MMP > MMP-16/MT3-MMP > MMP-24/MT5-MMP > MMP-25/MT6/MMP. Os resultados obtidos mostram, pela primeira vez, que as MT-MMPs estão diferencialmente expressas durante a ossificação endocondral normal em camundongos, sugerindo que a atividade biológica destas enzimas esteja atuando na degradação da matriz extracelular pericelular tanto durante a fase de desenvolvimento quanto de formação óssea.MMPs are zinc-dependent endopeptidases that, collectivelly, degrade all components of the ECM and generate bioactive molecules. They are able to remodelate the ECM during normal developmental processes such as embryogenesis and organogenesis, as well as in pathological processes such as tumoral invasion. The biological mineralization research looking for discovering the genes involved in the molecular mechanisms that control the endochondral ossification process. MMPs and their inhibitors (TIMPs and RECK) are responsable for bone matrix remodeling and, probably, determinate the level of its turnover. Thus, our goal was to evaluate the temporal-spatial expression of MMP-15/MT2-MMP, MMP-16/MT3-MMP, MMP-17/MT4-MMP, MMP-24/MT5-MMP, and MMP-25/MT6- MMP in mice embryos and newborns during endochondral ossification by Real Time PCR and immunohistochemistry. By immunohistochemistry, MMP-15/MT2-MMP signal was not detected. Both MMP-16/MT3-MMP and MMP-24/MT5-MMP were immunostained, mainly in osteoblasts at ossification front of growth plate. For MMP- 17/MT4-MMP, proliferative chondrocytes were immunopositive during chondrocyte differentiation (E13) as well as in hipertrophyc chondrocytes at the middle of cartilaginous template (E14). During cellular e vascular invasion (E15), mesenchymal cells from bone collar, probable pre-osteoblasts, were immunostained at primary bone marrow and osteoblasts at ossification front from E16 e PN1. For MMP- 25/MT6-MMP, perichondrial and periostal cellls were immunostained at cartilaginous template. All MT-MMPs evaluated showed the same transcript levels profile, being high in chondrocyte differentiation (E13), decreasing from E14 to E16. mRNA levels increased from E16 to E18 and, once more, decreasing from E18 to E20. Despite this profile, we observed difference levels: MMP-15/MT2-MMP > MMP-17/MT4-MMP > MMP-16/MT3-MMP > MMP-24/MT5-MMP > MMP-25/MT6/MMP. Our findings show, for the first time, that MT-MMPs are differentially expressed during normal endochondral ossification in mice, suggesting their biological activity act in pericellular extracellular matrix degradation in both development and bone formation.
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Scaduto, Lucimara Cristina Nakata. "Desenvolvimento e avaliação do desempenho de sistema óptico aplicado a sensoriamento remoto orbital." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-02032009-135211/.
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Este trabalho tem como objetivo apresentar o sistema óptico desenvolvido para a câmera WFI (Wide Field Imaging Camera) que integrará os satélites CBERS 3 e 4 (China Brazil Earth Resources Satellite). O Brasil é responsável por duas das câmeras dos satélites CBERS 3 e 4, a WFI e a MUX (Multispectral Camera). Estas câmeras são destinadas a sensoriamento remoto orbital da Terra. É a primeira vez que câmeras destinadas a este tipo de aplicação são inteiramente desenvolvidas e construídas no país. Devido ao alto nível de vibração durante o vôo, à exposição a vácuo e a radiação espacial durante o período de vida útil em órbita, o desenvolvimento desta câmera exige um cuidadoso processo de análise e avaliação do desempenho óptico em terra de modo a garantir seu funcionamento a bordo. Em especial, serão apresentados as análises ópticas realizadas durante a fase de projeto preliminar e os testes ópticos realizados em terra dos requisitos: distância focal, campo de visada - FOV, função de transferência de modulação - MTF, distorção, sensibilidade à polarização, transmitância, sensibilidade à luz espalhada e degradação da transmitância com a radiação espacial. Os resultados obtidos comprovaram que o desempenho do sistema óptico atende os requisitos de projeto.The purpose of this work is to present the optical system developed for the WFI camera (Wide Field Imaging Camera), which will be integrated to the CBERS 3 and 4 satellites (China Brazil Earth Resources Satellite). Brazil is responsible for two cameras of CBERS 3 and 4 satellites, WFI and MUX (Multispectral Camera). These cameras are used for orbital remote sensing of the Earth. It is the first time that cameras for this type of application are being entirely developed and built in our country. Due to the high vibration level during flight, the vacuum and space radiation exposure during the lifetime in orbit, the development of this camera requires a meticulous analysis process and evaluation of optical performance on the ground in order to ensure the effective operation on board. In particular, the optical analyses performed during the preliminary design and optical test requirements performed on ground will be presented, such as: focal length, field of view - FOV, modulation transfer function - MTF, distortion, polarization sensitivity, transmittance, stray light sensitivity and transmittance degradation with space radiation. The results obtained exhibit that the optical system performance satisfies all project requirements.
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Bradley, Karen Nicola. "The in vitro effects of muscarinic toxins MT2, MT3, MT4 and MT7 isolated from the venom of Dendroaspis angusticeps." Thesis, University of Strathclyde, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366919.
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Waxin, Viktor, and Oliver Forslund. "Succé eller fiasko? : - Hur påverkas bolagsavkastning av byte mellan Sveriges MTF-marknadsplatser." Thesis, Mittuniversitetet, Avdelningen för ekonomivetenskap och juridik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-30966.
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Det finns ett flertal tidigare studier som undersöker listbyten och dess effekt på ett bolags aktieavkastning. Merparten av dessa studier är dock baserade på den amerikanska aktiemarknaden. De svenska studierna som har genomförts undersöker effekten av listbyte från alternativa marknadsplatser (MTF) till huvudmarknaden (reglerad marknad). Det har framkommit att det finns ett kunskapsgap vad gäller hur aktieavkastning reagerar på marknadsplatsbyten på Sveriges MTF-er. Genom att endast fokusera på MTFmarknadsplatserna,AktieTorget, First North och Nordic MTF i Sverige och effekten av bytenmellan dessa marknadsplatser blir denna studie ett komplement till den tidigare forskningen inom området. I studien undersöks 39 svenska bolag som mellan åren 2007-2016 valt att byta marknadsplats. OMXPI är det jämförelseindex som använts för att jämföra bolagens avkastning med marknaden. Syftet med denna studie är att undersöka om det finns ett värdeför såväl bolagen som dess aktieägare att byta marknadsplats mellan AktieTorget, Nordic MTF och First North, istället för att stanna kvar på den ursprungliga listan. Detta syfte uppnås genom att studien undersöker bolagens aktieavkastning i samband med flytt till likvärdig, alternativ, marknadsplats för att ta reda på om bytet av marknadsplats skapar en negativ avkastning hos bolagen. Denna studie utförs i form av en kvantitativ eventstudie där marknadsplatsbytet utgör eventet. Studiens avsikt är inte att analysera de enskilda bolagen utan att istället ge en samlad bild av effekten på den aktiekursutveckling listbytet medför. Resultatet av studien visar att en negativ ackumulerad onormal avkastning (CAR) förekommer efter att marknadsplatsbytet genomförts. Vid beräkning av parametrarna imarknadsmodellen finner studien att den genomsnittliga ackumulerade onormala avkastningen (CAAR) för samtliga bolag är hela -47,88 %, 12 månader efter att marknadsplatsbytet genomförts.There are several previous studies that examine switches between marketplaces and how these changes impact companies share performance. The most foregoing research made on the subject share performance is based on the US stock market. Swedish studies made to the subject examine the share performance when companies move from one of the SwedishMultilateral Trading Facilities (MTF) to main market. The authors of this paper have noted that there is a gap of knowledge regarding share performance when companies move between the Multilateral Trading Facilities. By only examining the Swedish Multilateral Trading Facilities, AktieTorget, First North and Nordic MTF, and how moving between the lists affects the share performance, this study is an addition to the previous research in the field.This study examines 39 Swedish companies, which have changed list between 2007-2016. OMXSPI is the benchmark used in this study to compare the companies return with the market return. The purpose of this study is to examine if there is a value for both the companies and its shareholders to exchange marketplaces between the Swedish Multilateral Trading Facilities, AktieTorget, First North and Nordic MTF. This purpose is achieved byexamine the company’s stock price development before and after the change of market place and identify if the change creates a negative share performance. This study is conducted in the form of a quantitative event study where the marketplace change represents the event. The purpose is not to analyze the individual companies but to provide a comprehensive picture ofthe effect the marketplace changes have on the stock price development. The result of the study indicates that a negative accumulated abnormal return (CAR) occurs after the marketplace change. When calculating the parameters in the market model the study finds that the average accumulated abnormal return (CAAR) for all companies is a total of -47,88 % twelve months after the marketplace change.
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Dubé, Annie. "Étude des mécanismes impliqués dans l'activation de MTF-1 en réponse à l'hypoxie." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26379/26379.pdf.
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Millstone, Daniel Brucker, and Daniel Brucker Millstone. "Edge Response Characterization of Interferometers and the Effect of Aberrations." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625697.
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An edge response characterization technique to predict the ITF of an interferometer using non- interferometric measurements has been shown to be effective. This technique eliminates the need for phase objects to be used in the characterization process. Using coherent imaging with an irradiance sensitive detector and an irradiance step as a characterization artifact to determine an interferometer's ITF was proven viable for diffraction limited, defocused, astigmatic, and spherically aberrated systems. Simulations and collected data demonstrated agreement between the interferometric edge response characterization technique results and coherent imaging edge response characterization technique results. The effect that aberrations have on ITF curves has been investigated in this thesis and an understanding of the system behavior under aberrated conditions was investigated.
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Santos, Caio Augusto Marques dos [UNESP]. "Cronogeomorfologia do relevo da cidade de Marília através do método de traços de fissão - MTF." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/108680.
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000763321.pdf: 2204841 bytes, checksum: 7b83ab82bb6ed5922a3afb883d4c0d2a (MD5)O Planalto Residual de Marília é uma morfoescultura localizada no Planalto Ocidental Paulista e na morfoestrutura da Bacia Sedimentar do Paraná. Ele possui como substrato rochoso os arenitos da Formação Marília (Grupo Bauru – Cretáceo Superior). Com o objetivo de verificar o papel e a importância da tectônica para sua gênese e evolução, realizou-se a datação de 110 grãos de zircão e 59 de apatita via Método Traços de Fissão-MTF. Ele se baseia em análises termocronológicas, fundamentado no estudo quantitativo de perturbações no retículo cristalino desses minerais provocados pela fissão espontânea do núcleo do isótopo 238U, que ocorre durante o tempo geológico. Os resultados obtidos em zircão tiveram intervalo de idade que variou de 640 até 70 Ma. Nas apatitas a variação foi de 489 a 71 Ma. Esses intervalos grandes de idades foram atribuídos a várias procedências de rochas-fontes de sedimentos para o substrato rochoso do planalto. Ao analisar os espectros de idades dos dois minerais, agrupou-os em três conjuntos, aos quais se associaram eventos termotectônicos: idades superiores a 470 Ma - colisões brasilianas...
The Marília Residual Plateau is a morfosculpture located in Paulista Western Plateau and in morfostructure of the Paraná Sedimentary Basin. It has as rock substratum the sandstones of Marília Formation (Bauru Group - Late Cretaceous). In order to check the role and importance of tectonics to its genesis and evolution, it was done the dating of 110 grains of zircon and 59 of apatite by Fission Track Method - MTF. This method is based on thermal-chronological analyzes, grounded on the quantitative study of disturbances at the crystal lattice of these minerals caused by the spontaneous fission of the nucleus of 238U isotope, which occurs along geological time. The results obtained for zircon had ages break between 640 to 70 Ma. In apatite the variation was from 489 to 71 Ma. These large ranges of age were attributed to several origins of source rocks that provide the sediments to rock substratum of plateau. By analyzing the age spectrum of these two minerals, they were grouped into three sets, associated with thermo-tectonic events: ages over 470 Ma - brasiliano...
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Middlehurst, Lee Robert Jack. "Reconceiving cross-dressing : transphobia and support for MTF transgender people socialising in Manchester's gay village." Thesis, Manchester Metropolitan University, 2013. http://e-space.mmu.ac.uk/332120/.
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This thesis presents investigations of Male-To-Female (MTF) transgender people, mostly those who are cross-dressers/transvestites, socialising in Manchester’s Gay Village. A systematic review of the academic literature related to transgender issues indicates that no previous extensive research has been presented which analyses contemporary gender divergent (trans*) people in Manchester. The incomplete academic knowledge on current transgenderism, particularly transvestic identities, has been recognised by representatives of the Equality and Human Rights Commission and the UK Government Home Office. These deficient understandings comprise transphobic discriminations. Therefore, this thesis enhances academic information of contemporary transgenderism. This thesis includes findings and developed theories, deriving from aspects of Grounded Theory and Template Analysis, which reflect the deconstructive methodologies developed in postmodern theory. Postmodernism rejects the ‘grand narratives' of truth and science, with a greater emphasis upon the lived experience and expertise of those studied. The investigations undertaken for this study include a reflective/reflexive ethnographic analysis of the assistance to trans* people in Manchester by individuals and support organisations. Thirty-seven interviews with key informants were conducted. This thesis also deploys digital ethnography to examine Internet trans* supportive discourses, which either relate to or emerge from social circles linked to the Gay Village. Additionally, related quantitative information concerning trans* matters is re-presented which is drawn from 390,227 international online data inputs. Moreover, this study documents the annual transgender Sparkle celebrations in Manchester from 2005 to 2012, which attracts thousands of MTF transgender people (trans* women). The analysis is further sustained by critical explorations of transgender supportive political actions by agents of trans* organisations, the Manchester City Council and the UK national Government. The thesis employs a mix of methods and critical methodology. It challenges conceptual hierarchies in which the trans* person is low down the scale of social acceptance, and instead deconstructs contemporary ‘scientific knowledge’ to provide innovative insights into the actual experiences of present-day trans* identities. The research contributes to knowledge concerning transgenderism and highlights the potentially harmful impacts from inadequate medical, legal and academic recognitions of trans* people.
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Santos, Caio Augusto Marques dos. "Cronogeomorfologia do relevo da cidade de Marília através do método de traços de fissão - MTF /." Presidente Prudente, 2014. http://hdl.handle.net/11449/108680.
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Orientador: João Osvaldo Rodrigues NunesCoorientador: Carlos Alberto Tello Saenz
Banca: Alessandro Batezelli
Banca: Francisco Sergio Bernardes Ladeira
Banca: Isabel Vristina Moroz Caccia Gouveia
Banca: Eduardo Augusto Campos Curvo
Resumo: O Planalto Residual de Marília é uma morfoescultura localizada no Planalto Ocidental Paulista e na morfoestrutura da Bacia Sedimentar do Paraná. Ele possui como substrato rochoso os arenitos da Formação Marília (Grupo Bauru - Cretáceo Superior). Com o objetivo de verificar o papel e a importância da tectônica para sua gênese e evolução, realizou-se a datação de 110 grãos de zircão e 59 de apatita via Método Traços de Fissão-MTF. Ele se baseia em análises termocronológicas, fundamentado no estudo quantitativo de perturbações no retículo cristalino desses minerais provocados pela fissão espontânea do núcleo do isótopo 238U, que ocorre durante o tempo geológico. Os resultados obtidos em zircão tiveram intervalo de idade que variou de 640 até 70 Ma. Nas apatitas a variação foi de 489 a 71 Ma. Esses intervalos grandes de idades foram atribuídos a várias procedências de rochas-fontes de sedimentos para o substrato rochoso do planalto. Ao analisar os espectros de idades dos dois minerais, agrupou-os em três conjuntos, aos quais se associaram eventos termotectônicos: idades superiores a 470 Ma - colisões brasilianas...
Abstract: The Marília Residual Plateau is a morfosculpture located in Paulista Western Plateau and in morfostructure of the Paraná Sedimentary Basin. It has as rock substratum the sandstones of Marília Formation (Bauru Group - Late Cretaceous). In order to check the role and importance of tectonics to its genesis and evolution, it was done the dating of 110 grains of zircon and 59 of apatite by Fission Track Method - MTF. This method is based on thermal-chronological analyzes, grounded on the quantitative study of disturbances at the crystal lattice of these minerals caused by the spontaneous fission of the nucleus of 238U isotope, which occurs along geological time. The results obtained for zircon had ages break between 640 to 70 Ma. In apatite the variation was from 489 to 71 Ma. These large ranges of age were attributed to several origins of source rocks that provide the sediments to rock substratum of plateau. By analyzing the age spectrum of these two minerals, they were grouped into three sets, associated with thermo-tectonic events: ages over 470 Ma - brasiliano...
Doutor
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Paluncic, Jasmina. "Identification of Melanotransferrin (MTf), as a Novel Pro-Oncogenic Signalling Protein Involved in Melanoma Pathogenesis." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21152.
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It has been hypothesised that MTf may participate in melanoma progression due to the fact that the MTf plays a vital role in proliferation and tumorigenesis. This suggestion has been supported by the high levels of MTf expression in melanoma cells and the fact that previous studies demonstrated silencing MTf decreased melanoma tumour xenograft growth in vivo. In contrast, N-myc downstream regulated gene 1 (NDRG1), is a potent metastasis suppressor and acts to inhibit several oncogenic pathways, such as WNT, PI3K/AKT, etc. This thesis sought to elucidate the mechanism of MTf activity as a novel pro-oncogenic signalling protein involved in melanoma pathogenesis and whose molecular mechanism(s) of action remain unclear. Since metastasis accounts for most cancer deaths and is a major problem in melanoma, it was critical to further discover the molecular mechanisms that underlie NDRG1’s ability to inhibit progression and metastasis of melanoma. Furthermore, this thesis examined a promising anti-metastatic therapeutic strategy by assessing the novel, clinically trialled, anti-cancer agent, namely di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), which potently up-regulates NDRG1 in a variety of tumour cells. This dissertation consists of 6 chapters: A comprehensive literature review in Chapter 1 and a general materials and methods chapter (Chapter 2). This is followed by 3 results chapters, namely: Chapter 3 examining the inter-relationship between NDRG1 and MTf in vitro and in human melanoma samples; Chapter 4: exploring the effect of MTf on the crucial upstream receptors of WNT- and PI3K signalling, including LRP6, c-Met, VEGFR2 and FGFR1; and Chapter 5 understanding how MTf drives proliferation and activates these oncogenic pathways when c-Myc is silenced. These chapters are then followed by Chapter 6, which is a general discussion of findings and future directions.
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Danielsson, Rebecka, and Maki Yamada. "Identifiering av immateriella tillgångar : En studie om redovisning av tillgångar vid företagsförvärv på svenska MTF:er." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-24139.
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An accounting issue that has received attention is the issue of identification of intangible assets in acquisitions. This is because the company's result can be different depending on how much the company chooses to identify intangible assets separated from goodwill. As the practice for identification of intangible assets lacks clarity, companies are able to account for this in different ways. In this study, the manner in which identification of intangible assets are managed by companies listed on Swedish multilateral trading facilities and the manner in which companies distribute the purchase sum on net tangible assets, intangible assets and goodwill in comparison with listed companies is examined. The study emanates from a systems approach and is descriptive. It seeks to describe the concerns relating to identification of intangible assets in acquisitions rather than creating general conclusions. It alos emanates from a quantitative method where data is gathered from annual reports from the companies in question for the year 2012. The result showed that listed companies identified more intangible assets separated from goodwill. At the same time it was not possible to determine if this depended on whether or not the companies listed on multilateral trading facilities were better or worse than listed companies in the accounting of acquisitions. It also emerged that the information concerning acquisitions in annual reports left much to be desired. To improve the identification of intangible assets, clearer practice is required as well as auditors speaking up on the issue.Ett uppmärksammat redovisningsproblem är identifiering av immateriella tillgångar vid företagsförvärv. Företagets resultat kan bli annorlunda beroende på hur företaget väljer att identifiera immateriella tillgångar skilt från goodwill. Då praxis kring identifiering av immateriella tillgångar saknar tydlighet lämnas utrymme för företag att redovisa immateriella tillgångar på olika sätt. I studien undersöks hur identifiering av immateriella tillgångar hanteras av företag på svenska Multilateral Trading Facilities (MTF) och hur dessa företag fördelar köpeskillingen på netto materiella tillgångar, immateriella tillgångar och goodwill i jämförelse med börsnoterade företag. Studien utgår ifrån ett systemsynsätt och är deskriptiv. Uppsatsen syftar därför till att beskriva problematiken kring identifiering av immateriella tillgångar vid ett företagsförvärv snarare än att skapa generella slutsatser. Studien utgår från en kvantitativ metod där data samlas in från årsredovisningar för de aktuella företagen för år 2012. Resultatet visade att börsnoterade företag identifierade mer immateriella tillgångar skilt från goodwill. Samtidigt gick det inte att avgöra om det berodde på att företag på MTF:er var bättre eller sämre än börsnoterade företag i redovisningen av företagsförvärv. Utöver detta framkom dessutom att informationen kring företagsförvärv i årsredovisningen lämnar mycket att önska. För att förbättra identifieringen av immateriella tillgångar krävs tydligare praxis samt att revisorerna vågar säga ifrån.
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Brand, Amanda Salome. "Critical evaluation of the accuracy of the enumeration methodology of Coliforms and E. Coli in water from rivers used for the irrigation of fresh produce." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71955.
Full textAbstract:
Thesis (PhD)--Stellenbosch University, 2012.ENGLISH ABSTRACT: The accuracy of methods for the enumeration of coliforms and Escherichia coli present in river water intended for the irrigation of fresh produce has been critically evaluated to determine whether the results of the traditional method were reliable in indicating faecal pollution. The potential of rapid alternative methods were also explored. Baseline monitoring of the Berg River showed the presence of potential pathogens such as Salmonella, and also that E. coli levels exceeded international guidelines for the safe irrigation of minimally processed foods (MPFs) in 20.5% of cases, which indicated faecal intrusion. An exploratory study into the use of microbiological and physico-chemical parameters in predicting E. coli numbers, as a rapid alternative to direct enumeration, was conducted. These measurements, neither individually nor in combination, could accurately predict the E. coli numbers. The rapid method Colilert-18 was compared against multiple tube fermentation (MTF) for the enumeration of coliforms and E. coli. Spearman rank correlation coefficients showed that Colilert-18 had acceptable (r2=0.69) and fair (r2=0.74) correlations with MTF for coliform and E. coli enumeration, respectively. Bland and Altman statistics were used to determine pollution influence, and Colilert-18 showed increasing disagreement with MTF at very high concentrations of coliforms and E. coli. Bacterial isolates obtained from MTF reactions were identified using biochemical and mass spectrometry methods. These identifications revealed that the greatest contributors to inaccurate coliform enumeration by MTF were false negative coliforms which fail to produce gas from lactose. Numerical biochemical data suggested that these isolates may be able to use other carbohydrates preferentially over lactose. Inaccurate E. coli enumeration was caused by E. coli strains which could not utilise lactose or 4-methylumbelliferyl- -D-glucuronide (MUG), as well as non-E. coli isolates which were able to hydrolyse MUG. The method of transfer of bacteria between MTF media was also identified as problematic for accuracy. Monoplex polymerase chain reaction (PCR) differentiation of MTF isolates showed that detection of the uidA gene showed the greatest accuracy in the detection of E. coli, while the multiplex PCR protocol for detecting diarrheagenic E. coli pathotypes identified one strain of enteroaggregative E. coli (EAEC). A qualitative methodological risk classification was used, in combination with the individual reactions of MTF isolates, to elucidate their contribution to enumeration inaccuracy and to evaluate the effect of MUG and Levine-eosin methylene blue (L-EMB) agar. The classification indicated that inaccurate enumeration of E. coli was more problematic than that of coliforms, but revealed that the exclusion of MUG from MTF may increase the accuracy of E. coli enumeration. The omission of L-EMB would have very little effect on E. coli enumeration accuracy. This work confirmed that MTF is fairly reliable in the enumeration of coliforms and E. coli. Inaccuracies are primarily attributable to atypical organisms which are considered to make up a small proportion of the total bacterial population. Colilert-18 was shown to be an acceptably accurate alternative, and its rapid production of results can be highly advantageous in the monitoring of irrigation water used for MPFs.
AFRIKAANSE OPSOMMING: Die akkuraatheid van metodes vir die telling van kolivorme en Escherichia coli in rivier water, gebruik vir besproeiing van vars produkte, is krities geëvalueer om vas te stel of die resultate van tradisionele metodes betroubaar was in die aanduiding van fekale besoedeling. Die potensiaal van snelle alternatiewe metodes is ook ondersoek. Basislyn monitering van die Berg River het aangedui dat potensiële patogene soos Salmonella teenwoordig is, en dat E. coli vlakke internasionale riglyne vir die veilige besproeiing van minimaal geprosesseerde voedsels (MGVs) oorskry het in 20.5% van gevalle, wat dui op fekale besmetting. ‘n Ondersoekende studie van die bruikbaarheid van mikrobiologiese en fisieschemiese parameters in die voorspelling van E. coli getalle, as snelle alternatief tot direkte telling, is uitgevoer. Hierdie metings kon nie, individueel of in kombinasie, akkurate voorspellings van E. coli getalle maak nie. Die snelle metode Colilert-18 is vergelyk met veelvoudige buis fermentasie (VBF) in die telling van kolivorme en E. coli. Spearman rang korrelasie koëffisiënte het aangetoon dat Colilert- 18 aanvaarbare (r2=0.69) en goeie (r2=0.74) korrelasies met VBF gehad het vir kolivorm en E. coli tellings, respektiewelik. Bland en Altman statistiek is gebruik om die invloed van besoedeling te bepaal, en Colilert-18 het afnemende ooreenstemming met VBF getoon by baie hoë kolivorm en E. coli konsentrasies. Bakteriële isolate verkry vanaf VBF reaksies is geïdentifiseer met behulp van biochemiese en massa spektrometrie metodes. Hierdie identifikasies het getoon dat vals-negatiewe kolivorme, wat nie gas vanaf laktose kan produseer nie, die grootste bydraende faktor is in onakkurate kolivorm telling deur VBF. Biochemiese data het voorgestel dat hierdie isolate moontlik ander koolhidrate by voorkeur bo laktose gebruik. Onakkurate E. coli tellings is veroorsaak deur E. coli isolate wat nie laktose of 4-metielumbelliferiel- -D-glukuronied (MUG) kon verbruik nie, sowel as nie-E. coli isolate wat wel MUG kon hidroliseer. Die oordrag-metode van bakterieë tussen VBF media is ook geïdentifiseer as problematies. Monopleks polimerase ketting reaksie (PKR) onderskeiding van VBF isolate het aangedui dat opsporing van die uidA geen die grootste akkuraatheid vir die opsporing van E. coli het, terwyl die multipleks PKR protokol vir die opsporing van diarree-veroorsakende E. coli patotipes een stam van entero-aggregerende E. coli (EAEC) geïdentifiseer het. ‘n Kwalitatiewe metodologiese risiko klassifikasie is gebruik, in kombinasie met die individuele reaksies van VBF isolate, om hul bydrae tot telling onakkuraatheid vas te stel. Die effek van MUG en Levine-eosien metileenblou (L-EMB) agar is ook geëvalueer. Daar is bevind dat die onakkurate telling van E. coli meer problematies is as dié van kolivorme, maar ook dat die uitlating van MUG by VBF die akkuraatheid van E. coli tellings kan verhoog. Die uitlating van LEMB agar sal ‘n ignoreerbare effek hê op E. coli telling akkuraatheid. Hierdie werk het bevestig dat VBF akkuraat is in die telling van kolivorme en E. coli. Onakkuraathede word primêr toegeskryf aan atipiese organismes, wat beskou word as ‘n klein proporsie van die totale bakteriële bevolking. Colilert-18 is ‘n aanvaarbaar akkurate alternatief, en die metode se produksie van snelle resultate kan hoogs voordelig wees in die monitering van MGVs besproeiingswater.
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Lucas, Jennette. "The implications of the EBC scorecard on the skills, roles, and tools of Navy MTF comptrollers." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA351729.
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Thesis (M.S. in Management) Naval Postgraduate School, June 1998.Thesis advisor(s): O. Douglas Moses, James A. Scaramozzino. "June 1998." Includes bibliographical references (p. 105-108). Also available online.
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Carver, Kim Corley. "The added value of qualitative variables in a quantitative manpower model for DoD MTF IS departments." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA289999.
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Thesis (M.S. in Information Technology Management) Naval Postgraduate School, September 1994.Thesis advisor(s): James A. Scaramozzino, William B. Short. "September 1994." Includes bibliographical references. Also available online.
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Zandona, Ednaldo Alexandre [UNESP]. "Quantificação da resoluçao do sistema SPECT-CZT através do uso da função de transferência modulada (MTF)." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/87804.
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000749206.pdf: 2362410 bytes, checksum: f4f84a869a32983e7c75a2cda7ba0e17 (MD5)A medicina nuclear é uma especialidade médica que se ocupa de técnicas de imagem para observar o estado fisiológico dos tecidos ou órgãos de forma não invasiva, através da marcação de moléculas participantes desses processos, com isótopos radioativos, originando assim os chamados radionuclídeos. O SPECT é um equipamento que se utiliza de imagens planares, obtidas de vários ângulos ao redor do objeto de interesse, e, através de algoritmos computacionais, obtêm uma imagem tomográfica dessas projeções. Sua origem remete há aproximadamente cinquenta anos atrás, com criação da Câmara Anger (Hall Anger, 1964). Durante todo esse tempo, embora tenha havido alguma evolução, a estrutura dessas gama câmaras praticamente ficou Inalterada. Os constantes avanços em pesquisas empregando cristais semicondutores nos exames cintilográficos, bem como a necessidade do surgimento de novos sistemas detectores, compactos, com maior poder de resolução e alta sensibilidade conjugados a crescente preocupação mundial com a minimização das doses de radiação ionizante utilizadas nos exames diagnósticos e terapias, impulsionou o desenvolvimento de novos sistemas detectores. Recentemente, duas Grandes Empresas lançaram comercialmente novos sistemas de detecção para aquisições tomográficas em medicina nuclear, utilizando detectores do estado sólido, mais especificamente cristais de telureto de cádmio e zinco (CZT). Algumas vantagens desse tipo de detector são a melhora sensível da relação sinal/ruído, o aumento da resolução espectral e espacial, o que em suma, resultam numa maior nitidez das imagens obtidas. O emprego desses detectores abre novas perspectivas para os protocolos de imagem. Entretanto, devido a inúmeros fatores, os equipamentos ditos CZT estão focados na área cardiológica, e devido a características próprias requerem a reformulação dos protocolos de aquisição de imagem além daqueles destinados ao...
Nuclear medicine is a medical specialty that deals with imaging techniques to observe the physiological status of the tissues or organs noninvasively, by dialing molecules participating in this process, with radioactive isotopes, thus giving the so-called radionuclides. The SPECT is a device that uses planar images, taken from different angles around the object of interest, and, through computer algorithms, obtains a tomographic image of those projections. Its origin refers for nearly fifty years ago, with the creation of the Chamber Anger (Anger Hall, 1964). Throughout this time, although there has been some evolution, the structure of these gamma cameras was virtually unchanged. The constant advances in research employing semiconductor crystals in scintigraphic examinations, as well as the need for the creation of new detectors systems, compacts, higher resolution and high sensitivity; combined with growing worldwide concern with minimization of doses of ionizing radiation used in diagnostic tests and therapies, spurred the development of new detector systems. Recently, two large companies launched commercially new detection systems for nuclear medicine tomographic acquisitions, using solid-state detectors, specifically crystals of zinc and cadmium telluride (CZT). Some advantages of this type of detector are sensitive improvement of signal / noise ratio, increased spectral and spatial resolution, which in short, resulting in greater clarity of the images obtained. The use of these detectors opens news perspectives for imaging protocols. However, due to numerous factors, equipment said CZT are focused on cardiology area, and due to the inherent characteristics, require reformulation of image acquisition protocols beyond those intended for Quality Control
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Yoshioka, Hiromiti. "Função de transferência de modulação (MTF) na resolução geométrica de imagens na faixa do infravermelho termal." Instituto Nacional de Pesquisas Espaciais (INPE), 1985. http://urlib.net/sid.inpe.br/MTC-m13@80/2006/02.02.17.56.
Full textAbstract:
A função de transferência de modulação (MTF) de um sistema imageador é formada pelas MTFs dos subsistemas que a compõem. A MTF do sistema contribui para a formação do EIFOV (Campo instantâneo de visada efetivo). Calculou-se, neste trabalho, a MTF de um sistema imageador na faixa do infravermelho termal. Com isto foi possível estabelecer, teoricamente, o EIFOV do equipamento. Paralelamente foram realiza dos diversos experimentos que consistem em vôos sobre alvos com temperaturas e dimensões controladas (alvos simulados). As imagens foram analisadas em um microdensitômetro, e as curvas obtidas foram comparadas com as previstas teoricamente. Verificou-se que o EIFOV real é pior do que o EIFOV calculado, principalmente pelo movimento de rolamento da aeronave. uma plataforma estabilizada pode solucionar este problema.The modulation transfer function (MTF) of an imaging system is formed by the MTFs of the subsystems that compose it. The MTF of the system contributes to the formation of EIFOV (Countryside snapshot of effective target). It has been calculated in this work, the MTF of an imaging system in the thermal infrared range. With this it was possible to theoretically establish the EIFOV equipment. Alongside the various experiments were performed consisting of flights over targets with controlled temperatures and dimensions (simulated targets). The images were analyzed on a microdensitometer, and the curves were compared with those predicted theoretically. It was found that the actual worse EIFOV EIFOV than the calculated mainly by the rolling motion of the aircraft. a stabilized platform can solve this problem.
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Zandona, Ednaldo Alexandre. "Quantificação da resoluçao do sistema SPECT-CZT através do uso da função de transferência modulada (MTF) /." Botucatu, 2013. http://hdl.handle.net/11449/87804.
Full textAbstract:
Orientador: José Ricardo de Arruda MirandaBanca: José Roberto Saglieti
Banca: Eder Rezende Moraes
Resumo: A medicina nuclear é uma especialidade médica que se ocupa de técnicas de imagem para observar o estado fisiológico dos tecidos ou órgãos de forma não invasiva, através da marcação de moléculas participantes desses processos, com isótopos radioativos, originando assim os chamados radionuclídeos. O SPECT é um equipamento que se utiliza de imagens planares, obtidas de vários ângulos ao redor do objeto de interesse, e, através de algoritmos computacionais, obtêm uma imagem tomográfica dessas projeções. Sua origem remete há aproximadamente cinquenta anos atrás, com criação da Câmara Anger (Hall Anger, 1964). Durante todo esse tempo, embora tenha havido alguma evolução, a estrutura dessas gama câmaras praticamente ficou Inalterada. Os constantes avanços em pesquisas empregando cristais semicondutores nos exames cintilográficos, bem como a necessidade do surgimento de novos sistemas detectores, compactos, com maior poder de resolução e alta sensibilidade conjugados a crescente preocupação mundial com a minimização das doses de radiação ionizante utilizadas nos exames diagnósticos e terapias, impulsionou o desenvolvimento de novos sistemas detectores. Recentemente, duas Grandes Empresas lançaram comercialmente novos sistemas de detecção para aquisições tomográficas em medicina nuclear, utilizando detectores do estado sólido, mais especificamente cristais de telureto de cádmio e zinco (CZT). Algumas vantagens desse tipo de detector são a melhora sensível da relação sinal/ruído, o aumento da resolução espectral e espacial, o que em suma, resultam numa maior nitidez das imagens obtidas. O emprego desses detectores abre novas perspectivas para os protocolos de imagem. Entretanto, devido a inúmeros fatores, os equipamentos ditos CZT estão focados na área cardiológica, e devido a características próprias requerem a reformulação dos protocolos de aquisição de imagem além daqueles destinados ao ...
Abstract: Nuclear medicine is a medical specialty that deals with imaging techniques to observe the physiological status of the tissues or organs noninvasively, by dialing molecules participating in this process, with radioactive isotopes, thus giving the so-called radionuclides. The SPECT is a device that uses planar images, taken from different angles around the object of interest, and, through computer algorithms, obtains a tomographic image of those projections. Its origin refers for nearly fifty years ago, with the creation of the Chamber Anger (Anger Hall, 1964). Throughout this time, although there has been some evolution, the structure of these gamma cameras was virtually unchanged. The constant advances in research employing semiconductor crystals in scintigraphic examinations, as well as the need for the creation of new detectors systems, compacts, higher resolution and high sensitivity; combined with growing worldwide concern with minimization of doses of ionizing radiation used in diagnostic tests and therapies, spurred the development of new detector systems. Recently, two large companies launched commercially new detection systems for nuclear medicine tomographic acquisitions, using solid-state detectors, specifically crystals of zinc and cadmium telluride (CZT). Some advantages of this type of detector are sensitive improvement of signal / noise ratio, increased spectral and spatial resolution, which in short, resulting in greater clarity of the images obtained. The use of these detectors opens news perspectives for imaging protocols. However, due to numerous factors, equipment said CZT are focused on cardiology area, and due to the inherent characteristics, require reformulation of image acquisition protocols beyond those intended for Quality Control
Mestre
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Artells, Ester. "Anàlisi comparativa de les propietats coordinants de MT2 i MT3 envers Zn, Cd i Cu respecte altres isoformes de MT de mamífer (MT1 i MT4)." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/50996.
Full textAbstract:
Les metal·lotioneïnes (MTs) són unes metal·loproteïnes de baix pes molecular i un elevat contingut en residus de cisteïna que els confereixen una gran capacitat per coordinar i intercanviar ions metàl·lics pesants. A més dels residus de cisteïna, existeixen altres lligands no proteics, com els lligands sulfur àcid-làbils, que també poden participar en la coordinació metàl·lica. L’estudi de les capacitats coordinants de les MTs ha permès classificar-les segons la seva preferència metàl·lica en Zn-tioneïnes i Cu-tioneïnes, així com demostrar l’existència d’una gradació entre aquests dos tipus extrems de MTs, donant lloc a un conjunt de proteïnes amb característiques intermèdies que podrien comportar-se com Cu-tioneïnes o Zn-tioneïnes depenent de les necessitats específiques de la cèl·lula.
En els mamífers es troben 4 isoformes de metal·lotioneïna (MT1, MT2, MT3 i MT4). Aquestes 4 isoformes tenen 20 cisteïnes conservades en la seva seqüència proteica, i s’accepta que al unir-se a metalls divalents formen una estructura en dos dominis, β i α, que uneixen 3 i 4 ions divalents respectivament. MT1 i MT4 ja han estat estudiades per el nostre equip de recerca i han estat classificades com a Zn-tioneïna i Cu-tioneïna respectivament, així com els seus dominis.
Amb l’objectiu d’ampliar el coneixement actual d’aquestes proteïnes, en aquesta Tesi Doctoral s’ha estudiat la capacitat coordinant respecte als metalls zinc, cadmi i coure de les dues isoformes restants de MT de mamífer, MT2 i MT3. Aquest estudi té com objectiu diferenciar la preferència metàl·lica de MT2, comparant-la amb MT1 (considerades fins ara equivalents), determinar les característiques de coordinació metàl·lica de MT3 i relacionar-les amb la seva funció biològica i, finalment, integrar les MTs de mamífer en la classificació global de les metal·lotioneïnes. Per això, s’han sintetitzat mitjançant enginyeria genètica aquestes isoformes i els seus dominis per separat a partir de cultius bacterians suplementats amb Zn, Cd o Cu. Els complexos metàl·lics així obtinguts s’han caracteritzat químicament mitjançant tècniques espectroscòpiques i espectromètriques (ESI-MS, ICP-AES, CD i UV-Vis).
Els treballs realitzats amb la isoforma MT2 de mamífer i els seus dos dominis han permès conèixer les diferències de preferència metàl·lica respecta a MT1. Així, mentre que MT1 ha estat classificada com una Zn-tioneïna, MT2 presenta certes característiques de Cu-tioneïna, amb un domini β clarament Cu-tioneïna i un domini α Zn-tioneïna, que situa la isoforma en una pla intermedi en la classificació de les MTs. S’ha demostrat la relació entre les diferencies de seqüència entre les isoformes MT1 i MT2 i les seves preferències de coordinació metàl·lica, per la qual cosa es proposa que siguin considerades separadament, i no de manera conjunta com s’ha fet tradicionalment.
Per altra banda, MT3 és clarament una Cu-tioneïna, amb els dos dominis Cu-tioneïna. De fer, s’ha revelat com una MT de caràcter Cu-tioneïna més accentuat que la mateixa MT4.
Finalment, en aquesta Tesi Doctoral, s’ha pogut establir definitivament la gradació de preferència metàl·lica de totes les MTs de mamífer des de Zn-tioneïna a Cu-tioneïna tal i com segueix: MT1 > MT2 > MT4 > MT3, per posteriorment incloure aquestes isoformes en la classificació global de les MTs.Las metalotioneínas (MTs) son unas metaloproteínas de bajo peso molecular y un elevado contenido en residuos de cisteína que les confieren gran capacidad de coordinar e intercambiar iones metálicos pesados. Además de los residuos de cisteína existen otros ligandos no proteicos, como los ligandos sulfuro ácido-lábiles, que también pueden participar en la coordinación metálica. El estudio de las capacidades coordinantes de las MTs ha permitido clasificarlas según su preferencia metálica en Zn-tioneínas y Cu-tioneínas así como demostrar la existencia de una gradación entre estos dos tipos extremos de MTs, dando lugar a un conjunto de proteínas con características intermedias que podrían comportarse como Cu-tioneínas o Zn-tioneínas dependiendo de las necesidades específicas de la célula. En mamífero se encuentran 4 isoformas de metalotioneína (MT1, MT2, MT3 y MT4). Estas 4 isoformas tienen 20 cisteínas conservadas en su secuencia proteica y, se acepta que al unirse a metales divalentes forman una estructura en dos dominios, β y α, que unen 3 y 4 iones divalentes respectivamente. MT1 y MT4 ya han sido estudiadas por nuestro equipo de investigación y clasificadas como Zn-tioneína y Cu-tioneína respectivamente, así como sus dominios. Con el objetivo de ampliar el conocimiento actual sobre estas proteínas, en esta Tesis Doctoral se ha estudiado la capacidad coordinante respecto a los metales zinc, cadmio y cobre de las dos isoformas restantes de MT de mamífero, MT2 y MT3. Este estudio tiene como objetivo diferenciar la preferencia metálica de MT2, comparándola con MT1 (consideradas hasta el momento como equivalentes), determinar las características de coordinación de MT3 y relacionarlas con su función biológica y, finalmente, integrar las MTs de mamífero en la clasificación global de las metalotioneínas. Para ello, se han sintetizado mediante ingeniería genética estas isoformas y sus dominios por separado a partir de cultivos bacterianos suplementados con Zn, Cd o Cu. Los complejos metálicos así obtenidos, se han caracterizado químicamente mediante técnicas espectroscópicas y espectrométricas (ESI-MS, ICP-AES, CD y UV-Vis). Los trabajos realizados con la isoforma MT2 de mamífero y sus dos dominios han permitido conocer las diferencias de preferencia metálica respecto a MT1. Así pues, mientras MT1 se había clasificado como Zn-tioneína, MT2 exhibe ciertas características de Cu-tioneína, con un dominio β claramente Cu-tioneína y un dominio α Zn-tioneína, que sitúan la isoforma en un plano intermedio en la clasificación de las MTs. Se ha demostrado la relación entre las diferencias de secuencia entre las isoformas MT1 y MT2 y sus preferencias de coordinación metálica, por lo que se propone la consideración separada de estas dos isoformas, y no conjunta como se ha hecho tradicionalmente. Por otra parte, MT3 es claramente una Cu-tioneína, con ambos dominios Cu-tioneína. De hecho se ha revelado como una MT de carácter Cu-tioneína más acentuado que la propia MT4. Finalmente, en esta Tesis Doctoral, se ha podido establecer definitivamente la gradación de preferencia metálica de todas las MTs de mamífero desde Zn-tioneína a Cu-tioneína como sigue: MT1 > MT2 > MT4 > MT3, para posteriormente incluir las isoformas en la clasificación global de las MTs.
Metallothioneins (MTs) are low molecular weight proteins with a high cysteine content, which confers them the ability to bind heavy metal ions. As well as the Cys residues, other kind of non-proteic ligands (such as acid labile sulfide) exist in MTs that also could participate in metal coordination. The study of the MT’s coordinative abilities has allowed classifying them following their metallic preferences as Zn- and Cu-thioneins, and to demonstrate the existence of a gradation between these two extreme MT’s types. These proteins with intermediate features could thus behave as Cu-thionein or Zn-thionein depending on the specific requirements of cell. In mammals, 4 isoforms of MT were found (MT1, MT2, MT3 and MT4). These 4 isoforms show 20 preserved Cys, and it’s accepted that in the union with divalent metals, they form a 2-domain structure (β and α) with 3 and 4 divalent ions, respectively. Our research team has already studied MT1 and MT4 and their domains, and classified them as Zn-thionein and Cu-thionein, respectively. With the objective of increasing the actual knowledge about these proteins, the Zn(II), Cd(II) and Cu(I) coordinative abilities of the 2 other mammal’s MT isoforms, MT2 and MT3 were studied. The goal of this PhD was to differentiate the metallic preferences of MT2 and MT1 (which were formerly considered as equal), to determinate the metallic coordinative characteristics of MT3 with respect to their biological function and finally, to integrate the mammal’s MT into the global MT classification. Using genetic engineering, these isoforms and their individual domains were synthetized from bacterial cultures in presence of Zn, Cd or Cu. The metal complex was chemically characterized using spectroscopy and spectrometry technics (ESI-MS, ICP-AES, CD i UV-Vis). These experiments showed different metallic preferences between MT2 and MT1. MT1 was identified as a Zn-thionein, whereas MT2 displays some characteristics of Cu-thioneins. The β domain of MT2 is a Cu-thionein and the α domain is a Zn-thionein, classifying MT2 as an intermediate MT into the global MT classification. The relationship between the sequence differences of MT1 and MT2, and their metallic coordinative preferences were demonstrated. These results suggest that MT1 and MT2 should be considered separately and not together as it was traditionally studied. On the other hand, MT3 is clearly a Cu-thionein, with 2 Cu-thionein domains, with a stronger Cu-thionein characteristic than MT4. Finally, this work has determined a gradation of metallic preferences of all mammal’s MTs, from Zn-thionein to Cu-thionein, as follow: MT1 > MT2 > MT4 > MT3. These isoforms were included into the global MT classification.
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Miller, Michael E. "Effects of field of view, MTF shape, and noise upon the perception of image quality and motion." Diss., This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10022007-145303/.
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Accorsi, Eugenio. "Caratterizzazione fisica di apparati per tomosintesi digitale della mammella." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9581/.
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In questo lavoro di tesi sono state studiate le caratteristiche di una macchina per tomosintesi Fujifilm AMULET Innovality in uso presso l'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) di Meldola.
Le valutazioni sono state fatte utilizzando diversi fantocci, uno dei quali costruito durante il lavoro di tesi. Per la valutazione delle immagini di mammografia digitale e di tomosintesi sono state seguite le linee guida della International Electrotechnical Commission (IEC) e della European Reference Organisation for Quality Assured Breast Screening and Diagnostic Services (EUREF).
Per lo studio delle mammografie digitali sono stati valutati, utilizzando i software COQ e ImageJ, i parametri di NPS, MTF e DQE.
Per lo studio delle immagini di tomosintesi sono stati appositamente sviluppati degli algoritmi in linguaggio Java, integrati poi all'interno del software COQ. Il programma sviluppato ha permesso di valutare ASF, MTF, NPS e omogeneità delle immagini ricostruite.
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Parasuram, Priya Laity John H. "Homologous modeling and structure calculation of the MTF-1 zinc finger domain protein using NMR and computational techniques." Diss., UMK access, 2006.
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Thesis (M.S.)--School of Computing and Engineering. University of Missouri--Kansas City, 2006."A thesis in computer science." Typescript. Advisor: John H. Laity. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 1, 2007. Includes bibliographical references (leaves 81-88). Online version of the print edition.
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Aronsson, Johan, and Joakim Erlandsson. "Avskaffandet av revisionsplikten : noterade bolags agerande." Thesis, Högskolan i Borås, Institutionen Handels- och IT-högskolan, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-19485.
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EU vill minska den administrativa bördan med 25 procent för företag inom EU, detta för att de skall bli mer konkurrenskraftiga i den allt mer globaliserade ekonomin. Ett led i detta arbete är att ta bort revisionsplikten för vissa aktiebolag. Svenska statens offentliga utredningar har tagit fram ett förslag om ett avskaffande av revisionsplikten för aktiebolag. Om de inte överskrider någon utav nedanstående punkter, behöver inte företaget revideras utav en revisor.• Balansomslutning på 41,5 miljoner kronor• Nettoomsättning på 83 miljoner kronor• Fler anställda än 50(SOU 2008:32)Det mesta tyder på att förslaget kommer att gå igenom vilket i så fall skulle innebära att endast cirka fyra procent av aktiebolagen skulle vara tvungna att anlita en revisor.Syftet med studien är att studera hur företag noterade på oreglerade handelsplatser kommer att agera om förslaget att avskaffa revisionsplikten blir verklighet.För att kunna göra vår studie har vi använt oss av sekundärdata såväl som primärdata. Sekundärdatan har varit i form av tidigare forskning inom området och bildar vår teoretiska referensram. Primärdatan har vi skapat genom en kvantitativ studie, respondenterna är bolag noterade på oreglerade marknadsplatser, datan redovisas i empiri kapitlet. Teori och empiri knyts samman i analysen.Vår studie visar att en majoritet av bolagen, 20 av 28, anger att de kommer att fortsätta med revision även efter ett avskaffande a revisionsplikten. Resultatet överensstämmer väl med tidigare forskning, och vi anser därför att reliabiliteten är hög. Undersökningen pekar även på ett tydligt samband mellan företagens storlek och viljan att behålla sin revisor. Av de minsta bolagen i studien är 7 av 16 osäkra på om de kommer fortsätta att anlita en revisor.
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Rayford, II Cleveland Eugene. "Digital Breast Tomosynthesis (DBT) Computational Analysis With Parallel Imaging Configurations To Improve Breast Cancer Detection." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/574.
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The best way to conquer breast cancer is early detection of the disease. Research studies show that earlier detection results in the increase of life span of the affected person. Traditional two-dimensional mammography is the most prevalent method used in detecting breast cancer. Recently, a three-dimensional digital breast tomosynthesis (DBT) system has been created, which is hopeful to surpass the technology of traditional mammography systems. The DBT system can provide three-dimensional information, allowing physicians to reduce the amount of false negative screening in addition to better monitoring of breast cancer and to catch lesions that may be otherwise cancerous. In this research, the View Angle (VA) and number of projection images (N) were investigated and compared with parallel imaging configurations using two reconstruction algorithms, including Back Projection (BP) and Shift-And-Add (SAA). Modulation Transfer Function (MTF) analyses were conducted with both algorithms, in order to determine which method displayed better image qualities to ultimately improve the detection of breast cancer.
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Lintanff, Marion. "Etude du fonctionnement psychique de jeunes femmes en demande de changement de sexe : approche psychanalytique et projective." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05H124.
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Eibauer, Matthias J. M. [Verfasser], Stephan [Akademischer Betreuer] Nickell, Martin [Akademischer Betreuer] Zacharias, and Wolfgang [Akademischer Betreuer] Baumeister. "Korrektur der Transferfunktionen CTF und MTF in der Kryoelektronentomographie / Matthias Eibauer. Gutachter: Martin Zacharias ; Wolfgang Baumeister. Betreuer: Stephan Nickell." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1019589272/34.
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Joshi, Jimish Dilip. "Characterization and Improvement of a Cone-Beam CT Scanner for Quantitative Imaging." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1284997522.
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Choi, Junoh. "Optical Performance Test & Analysis of Intraocular Lenses." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/195496.
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Cataract is a condition in the eye that if left untreated, could lead to blindness. One of the effective ways to treat cataract is the removal of the cataractous natural crystalline lens and implantation of an artificial lens called an intraocular lens(IOL). The designs of the IOLs have shown improvements over the years to further imitate natural human vision. A need for an objective testing and analysis tool for the latest IOLs grow with the advancements of the IOLs.In this dissertation, I present a system capable of objective test and analysis of the advanced IOLs. The system consists of-Model eye into which an IOL can be inserted to mimic conditions of the human eye.-Modulation Transfer Function measurement setup capable of through-focus test for depth of field studies and polychromatic test for study of effects of chromatization.-Use of Defocus Transfer Function to simulate depth of field characteristic of rotationally symmetric multifocal designs and extension of the function to polychromatic conditions.-Several target imaging experiments for comparison of stray light artifacts and simulation using a non-sequential ray trace package.
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Chavez, Anthony S. "Capitation base resource allocation : does it provide the necessary financial incentives for the MTF to achieve technical and allocative efficiency? /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1995. http://handle.dtic.mil/100.2/ADA305898.
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Svärdström, Fredrik. "Nya regler, ny marknad : Hur påverkas volatiliteten på den lokala marknaden när aktier noteras för handel på en MTF-plattform." Thesis, Umeå universitet, Nationalekonomi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60849.
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Patru, F., S. Esposito, A. Puglisi, A. Riccardi, E. Pinna, C. Arcidiacono, J. Antichi, et al. "The LBTI Fizeau imager – II. Sensitivity of the PSF and the MTF to adaptive optics errors and to piston errors." OXFORD UNIV PRESS, 2017. http://hdl.handle.net/10150/625964.
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We show numerical simulations with monochromatic light in the visible for the LBTI Fizeau imager, including opto-dynamical aberrations due here to adaptive optics (AO) errors and to differential piston fluctuations, while other errors have been neglected. The achievable Strehl by the LBTI using two AO is close to the Strehl provided by a single standalone AO system, as long as other differential wavefront errors are mitigated. The LBTI Fizeau imager is primarily limited by the AO performance and by the differential piston/tip-tilt errors. Snapshots retain high-angular resolution and high-contrast imaging information by freezing the fringes against piston errors. Several merit functions have been critically evaluated in order to characterize point spread functions and the modulation transfer functions for high-contrast imaging applications. The LBTI Fizeau mode can provide an image quality suitable for standard science cases (i.e. a Strehl above 70 per cent) by performing both at a time: an AO correction better than approximate to lambda/18RMS for both short and long exposures, and a piston correction better than approximate to lambda/8 RMS for long exposures or simply below the coherence length for short exposures. Such results, which can be applied to any observing wavelength, suggest that AO and piston control at the LBTI would already improve the contrast at near-and mid-infrared wavelengths. Therefore, the LBTI Fizeau imager can be used for high-contrast imaging, providing a high-Strehl regime (by both AO systems), a cophasing mode (by a fringe tracker) and a burst mode (by a fast camera) to record fringed speckles in short exposures.
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Yan, Yi. "Statistical Analysis Of cDNA Microarrays – A Systematic Approach to Identify MTF-1 Mediated Gene Expression Profile in Response to Cadmium." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054209876.
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Reese, Colin Edward. "The direct measurement of system Modulation Transfer Function (MTF) for an AN/AVS-6 Aviator's Night Vision Imaging System (ANVIS)." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-03042009-040526/.
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Yang, Yi. "Statistical analysis of cDNA microarrays a systematic approach to identify MTF-1 mediated gene expression profile in response to cadmium /." Cincinnati, Ohio : University of Cincinnati, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1054209876.
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Maschio, Maria Celeste. "Performance evaluation of detector for digital radiography." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8317/.
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Lo scopo di questo lavoro è la caratterizzazione fisica del flat panel PaxScan4030CB Varian, rivelatore di raggi X impiegato in un ampio spettro di applicazioni cliniche, dalla radiografia generale alla radiologia interventistica.
Nell’ambito clinico, al fine di una diagnosi accurata, è necessario avere una buona qualità dell’immagine radiologica mantenendo il più basso livello di dose rilasciata al paziente.
Elemento fondamentale per ottenere questo risultato è la scelta del rivelatore di radiazione X, che deve garantire prestazioni fisiche (contrasto, risoluzione spaziale e rumore) adeguati alla specifica procedura. Le metriche oggettive che misurano queste caratteristiche sono SNR (Signal-to-Noise Ratio), MTF (Modulation Transfer Function) ed NPS (Noise Power Spectrum), che insieme contribuiscono alla misura della DQE (Detective Quantum Efficiency), il parametro più completo e adatto a stabilire le performance di un sistema di imaging. L’oggettività di queste misure consente anche di mettere a confronto tra loro diversi sistemi di rivelazione.
La misura di questi parametri deve essere effettuata seguendo precisi protocolli di fisica medica, che sono stati applicati al rivelatore PaxScan4030CB presente nel laboratorio del Centro di Coordinamento di Fisica Medica, Policlinico S.Orsola.
I risultati ottenuti, conformi a quelli dichiarati dal costruttore, sono stati confrontati con successo con alcuni lavori presenti in letteratura e costituiscono la base necessaria per la verifica di procedure di ottimizzazione dell’immagine radiologica attraverso interventi sul processo di emissione dei raggi X e sul trattamento informatico dell’immagine (Digital Subtraction Angiography).
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Rauchmiller, Robert Frank 1959. "MEASUREMENT OF THE LANDSAT THEMATIC MAPPER MTF USING A TWO-DIMENSIONAL PHASED ARRAY OF POINT SOURCES (MODULATION TRANSFER, SATTELITE, POINT SPREAD FUNCTION)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276361.
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Zhou, Ping. "ERROR ANALYSIS AND DATA REDUCTION FOR INTERFEROMETRIC SURFACE MEASUREMENTS." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195309.
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High-precision optical systems are generally tested using interferometry, since it often is the only way to achieve the desired measurement precision and accuracy. Interferometers can generally measure a surface to an accuracy of one hundredth of a wave. In order to achieve an accuracy to the next order of magnitude, one thousandth of a wave, each error source in the measurement must be characterized and calibrated.Errors in interferometric measurements are classified into random errors and systematic errors. An approach to estimate random errors in the measurement is provided, based on the variation in the data. Systematic errors, such as retrace error, imaging distortion, and error due to diffraction effects, are also studied in this dissertation. Methods to estimate the first order geometric error and errors due to diffraction effects are presented.Interferometer phase modulation transfer function (MTF) is another intrinsic error. The phase MTF of an infrared interferometer is measured with a phase Siemens star, and a Wiener filter is designed to recover the middle spatial frequency information.Map registration is required when there are two maps tested in different systems and one of these two maps needs to be subtracted from the other. Incorrect mapping causes wavefront errors. A smoothing filter method is presented which can reduce the sensitivity to registration error and improve the overall measurement accuracy.Interferometric optical testing with computer-generated holograms (CGH) is widely used for measuring aspheric surfaces. The accuracy of the drawn pattern on a hologram decides the accuracy of the measurement. Uncertainties in the CGH manufacturing process introduce errors in holograms and then the generated wavefront. An optimal design of the CGH is provided which can reduce the sensitivity to fabrication errors and give good diffraction efficiency for both chrome-on-glass and phase etched CGHs.
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Romualdo, Larissa Cristina dos Santos. "Restauração de imagens mamográficas digitais utilizando o filtro de Wiener no domínio de Anscombe e o filtro inverso da MTF no domínio da frequência." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-17112009-084935/.
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Este trabalho tem por objetivo o desenvolvimento de uma nova técnica de pré-processamento de imagens mamográficas digitais para melhorar o desempenho dos esquemas computacionais de auxílio ao diagnóstico (CAD) e para auxiliar na detecção precoce do câncer de mama. O método proposto efetua uma restauração nas imagens mamográficas utilizando, em uma primeira etapa, a transformada de Anscombe e o filtro de Wiener para redução do ruído quântico. Posteriormente, é utilizado o filtro inverso da função de transferência de modulação (MTF) do sistema de imagem para realce das estruturas de interesse na mamografia, como as microcalcificações, que podem ser um indicativo de câncer de mama em seu estágio inicial. Imagens mamográficas restauradas pelo método proposto foram utilizadas na avaliação de um esquema CAD para detecção automática de microcalcificações. Os resultados mostraram que o desempenho do esquema CAD apresentou uma melhora significativa quando imagens restauradas foram utilizadas, mesmo para imagens de mamas densas, que resultam normalmente em baixa taxa de detecção devido ao baixo contraste.This work aims to developing a new technique for pre-processing digital mammographic images in order to improve the performance of computer aided-diagnosis schemes (CAD) and to assist in early detection of breast cancer. The proposed method performs a restoration in mammographic images using in a first step, the Anscombe transform and Wiener filtering to reduce image quantum noise. Subsequently, it was used the inverse modulation transfer function filtering (MTF) considering the imaging system to enhance structures of interest in mammography, such as microcalcifications, which may be an indicative of breast cancer in its early stage. Mammographic images restored by the proposed method were used in the evaluation of a CAD scheme for automatic detection of microcalcifications. The results showed that the performance of the CAD scheme had a significant improvement when restored images were used, even for images of dense breasts, which often results in low detection rate due to low contrast.
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Nghiem, Xuan Jean. "Performances orientées système de détecteurs infrarouge à super-réseaux en cryostat opérationnel." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLX113/document.
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De nombreuses filières de détecteurs coexistent dans le domaine infrarouge (longueur d’onde entre 1µm et 50µm). Chacune possède ses avantages et ses inconvénients (coût, performance, compacité …). Certaines filières sont bien établies et disponibles commercialement alors que d’autres sont encore émergentes. La filière super-réseaux (SR) est une filière récemment commercialisée. Elle repose sur l’empilement périodique de semiconducteurs (InAs/GaSb), donnant un détecteur quantique capable de détecter des longueurs d’ondes comprises entre 1 et 32µm typiquement.L’objectif de cette thèse est d’évaluer le potentiel de la filière super-réseaux en cryostat opérationnel à l’aide de fonctions de mérite orientées système qui tiennent compte du packaging entourant le détecteur. Nous nous concentrerons sur la Fonction de Transfert de Modulation (FTM), décrivant la résolution du système ainsi que sur le rapport Bruit Spatial Fixe Résiduel sur Bruit Temporel (BSFR/BT), décrivant la stabilité temporelle de la qualité image.Ce travail a ainsi permis de confirmer deux promesses des SR en moyen infrarouge : d’une part, la grande stabilité temporelle de la qualité image et d’autre part le faible nombre de pixels clignotants. Par ailleurs, les bancs de mesures de FTM et de stabilité temporelle développés au cours de la thèse pourront être adaptés pour caractériser d’autres filières dans les mêmes conditions de mesureMany photodetector technologies coexist in the infrared domain (wavelength between 1µm and 50µm). Each of them comes with its assets and drawbacks (cost, performance, compactness, etc.). Some technologies are well established and available while others are still under development. The superlattice technology (SL) recently made its way into the market. It is based on the periodic stack of semiconductors (InAs/GaSb), giving a quantum detector capable of detecting wavelengths between 1 and 32µm typically. Like other quantum infrared detectors, superlattice photodetectors need to be cooled at cryogenic temperature to maximize their electro-optical performance.The objective of this thesis is to evaluate the potential of the SLSL in IDDCA using system-oriented figures of merit, which also take into account the packaging of the detector. The present work is focused on the Modulation Transfer Function, which describes the system resolution and the ratio Residual Fixed Pattern Noise over Temporal Noise (RPFN/TN), which evaluates the temporal stability of the image quality.This present work successfully confirmed two promises of the SL in midwave infrared : the excellent stability of the image quality and the low flickering pixel count. Besides, the experimental benches developped (MTF and temporal stability alike) can be adapted to perform similar measurements with other technologies
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Murray, Mark W. Quigley Jason M. "Automatically generating a distributed 3D virtual Battlespace using USMTF and XML-MTF air tasking orders, Extensible Markup Language (XML) and Virtual Reality Modeling Language (VRML)." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA381836.
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Thesis (M.S. in System Technology)--Naval Postgraduate School, June 2000.Thesis advisor(s): , Brutzman, Donald P. ; Boger, Dan. "June 2000." Includes bibliographical references (p. 373-374). Also available in print.
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Murray, Mark W., and Jason M. Quigley. "Automatically generating a distributed 3D virtual Battlespace using USMTF and XML-MTF air tasking orders, Extensible Markup Language (XML) and Virtual Reality Modeling Language (VRML)." Thesis, Monterey, California. Naval Postgraduate School, 2000. http://hdl.handle.net/10945/7638.
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For the past three decades, the Department of Defense (DoD) has used the U.S. Message Text Format (USMTF) as the primary means to exchange information and to achieve interoperability between joint and coalition forces. To more effectively exchange and share data, the Defense Information Systems Agency (DISA), the lead agency for the USMTF, is actively engaged in extending the USMTF standard with a new data sharing technology called Extensible Markup Language (XML). This work translates and synthesizes Air Tasking Order (ATO) data messages written in XML into a three-dimensional (3D) air attack plan within a virtual environment through the use of the Virtual Reality Modeling Language (VRML)
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Apte, Uday M., and Keebom Kang. "Lean Six Sigma in healthcare: combating the military's escalating pharmacy costs." Monterey, California: Naval Postgraduate School, 2009. http://hdl.handle.net/10945/11064.
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Approved for public release, distribution unlimitedApproved for public release; distribution unlimited.
Healthcare costs throughout the United States are on the rise, drawing increased scrutiny from government officials and Congress. The cost of pharmacy operations and pharmaceuticals is growing at a rate that is alarmingly higher than that of the total cost of military healthcare itself. Recent congressional legislation has essentially given the Department of Defense the ultimatum to cut costs for beneficiaries wherever possible, or risk having benefits arbitrarily cut by Congress. In the face of this possibility, cutting costs through better business practices must be explored, particularly within the area of pharmacy operations. This project explores the potential cost savings that can be realized by implementing Lean Six Sigma (LSS) methodology in the pharmacy operations of the DoD Medical Treatment Facilities (MTF). This research proves that implementing Lean Six Sigma methodology will improve military pharmacy operations, often at little cost, while realizing significant savings and increased customer satisfaction.
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Crotty, Maureen. "Signal to Noise Ratio Effects on Aperture Synthesis for Digital Holographic Ladar." University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1355245759.
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Destruel, Christophe. "Modélisation de la chaîne d'acquisition des images : application à des solutions innovantes." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTS046.
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Cette thèse présentée dans le cadre de la validation des acquis de l'expérience s'inspire de la modélisation de la chaîne d'acquisition des images pour proposer des solutions innovantes aux différents sujets qui ont été abordés.Le premier sujet s'intéresse à la géométrie des dispositifs de capture d'images, notamment spatiaux et aériens, pour enrichir un modèle 3D. Cet ajout s'appuie sur la géométrie et la radiométrie des images capturées pour accroitre les informations disponibles par la fusion d'un MNT avec des modèles exogènes et la texturation automatique des facettes par les meilleures images disponibles. Les problématiques de visualisation de ces données ont également été abordées, que ce soit sous forme 3D (navigation virtuelle) ou 2D (images stéréoscopiques). Le second s'appuie sur un modèle radiométrique de la chaîne image, et plus particulièrement sur la modélisation en optique de Fourier, pour proposer un nouveau code graphique 2D, sensible aux phénomènes intervenant lors des processus de impression/numérisation. Cette sensibilité a été optimisée pour permettre aux outils proposés de distinguer un document original de ses photocopies. Ce code est conçu pour être imprimable sur n'importe quel appareil de bureau, utilisant des encres standards et contrôlable par un dispositif portable courant.Enfin le troisième utilise le bruit inhérent à tout capteur d'images pour détecter automatiquement une photographie ayant subi une altération pouvant traduire une falsification. Une nouvelle métrique ainsi qu'une méthode adaptée ont été proposées en s'appuyant sur la couleur du bruit et sur un parcours par fenêtres variables. La zone ayant subi une altération est soulignée afin de faciliter l'intervention d'un éventuel opérateur.Les méthodes mises au point ainsi que les résultats obtenus sont décrits et détaillés dans ce document organisé de manière chronologique et s'appuyant sur la chaîne image qui est le lien permanent entre ces travauxThis PhD thesis focus on how the model of the image acquisition workflow can be used to propose new approachs to several research topics. In this work, we show how to apply this model to propose innovative solutions to three different fields of application.The first application is related to the geometry of capture devices, mainly spatial and aerial, used to produce images in order to enhance a 3D model. This enhancement, which increase the available information, is realized considering both geometric and radiometric aspects: classic DEM is enhanced by real 3D models which are fully textured by the best available images. In this work we cut the geometric triangles in radiometric faces to ensure the quality and the re-usability of the final mock-up.The second application is based on the radiometric part of the full image workflow model to propose a new 2D graphic code sensitive to print and scan effects that makes us able to distinguish an original document from its photocopies. This code is printable on any office printer, using standard inks and controllable by anyone using a common smartphone.Finally, the third application uses the noise inherent to all image sensor to detect a photography that has been forged by an attacker. In this part, we propose a new metric and a specific method to automatically detect such attacks. The altered area is highlighted to facilitate the perception of a final operator.This document presents the methods and the results over this three research fields. It summarizes the work I have done over several years
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Boswell, Jacqueline M. "The effect of the lymphokine(s) MIF/MAF on murine macrophage behaviour." Thesis, University of Leicester, 1985. http://hdl.handle.net/2381/34201.
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Migration inhibition factor (MIF) was isolated from the mouse, rat, Xenopus laevis and the newt Triturus cristatus. These MIFs were used to investigate the specificity of the molecule and it was found that MIF is not species specific and that animals with an evolutionarily sophisticated immune response are responsive to MIFs produced by animals which show much less complex immune responses. Macrophages are one of the few normal adult cell types which show motility as part of their functional phenotype and this process can by manipulated in vitro by the presence or absence of MIF. Using LM and EM the effects of MIF and substrate on locomotion and macrophage-substrate adhesion were investigated. The question of macrophage heterogeneity was addressed to determine whether macrophages can be activated for a wide range or only a limited number of functions. The results obtained suggest that macrophages become committed along particular pathways depending on external stimuli from the micro-environment surrounding the cell and that performance of particular functions precludes the cell from performing certain other functions. Macrophage activating factor (MAF) co-chromatographs with MIF and was isolated with MIF. The effect of MIF/MAF and effector : target cell ratio on macrophage anti-tumour activity was also investigated. Macrophages were found to have a cytostatic effect at a much lower effector : target cell ratio than that required for cytolysis of transformed cells. Also, macrophages lyse target cells at a lower effector:target cell ratio when cultured on a collagen rather than a glass substrate. Macrophages are also attracted through collagen towards transformed cells preferentially. Pretreatment with MAF enhances the cytolyic response of macrophages. This response is increased further by pretreating macrophages with LPS and MAF when both pretreatment time and sequence are important in determining which functions macrophages perform.
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Costa, Hamilton Baptista da. "Investigação de qualidade para comparação de sistemas de imagem em radiologia odontológica." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/18/18133/tde-26122005-185903/.
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O presente trabalho de pesquisa trata da investigação de parâmetros de qualidade aplicados a sistemas de imagem em radiologia odontológica. Para isso, foram levantados parâmetros propostos pela Portaria nº 453 de 1998 da Secretaria de Vigilância Sanitária do Ministério da Saúde em aparelhos de raios X odontológicos e determinadas funções de transferência de modulação (FTM), como método para a avaliação da resolução espacial de sistemas de radiologia odontológica digital. Com base nesses dados, comparou-se três sistemas digitais diretos (DIGORA, DENOPTIX e CygnusRay) e um sistema digital indireto, baseado no scanner Umax PowerLook 1120. Essa comparação evidenciou, para esse caso, a melhor qualidade, em termos de resolução espacial, do sistema indireto estudado e a relativa equivalência dos sistemas digitais entre si, quando comparados em suas resoluções máximas (em número de pontos por polegada). Também foi possível validar o uso do método de simulação computacional para a obtenção da FTM de sistemas radiográficos odontológicosThis work has investigated quality parameters applied to odontologic radiographic image systems. In order to achieve this purpose, parameters related to the Portaria nº 453 of 1998 of Secretaria de Vigilância Sanitária do Ministério da Saúde have been checked and modulation transfer functions (MTF) have been determined. These information has been used to compare three differents direct radiographic images systems (DIGORA, DENOPTIX e CygnusRay) and one indirect, based on scanner Umax PowerLook 1120. The obtained data has showed, in this case, the better performance, in terms of spatial resolution, of the indirect system and the relative equivalency of the direct systems, when configured with the maximum resolution (in term of dpi). The work has validated the computer simulation process in order to generate the MTF of odontologic radiographic image systems
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Karpov, Boris, and Johan Klevenstedt. "Nyintroduktioner på svenska handelsplatser : Har nyintroduktioner genererat högre avkastning än NASDAQ OMXSPI?" Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-72870.
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Denna studie har genomförts i syfte att undersöka huruvida nyintroduktioner generar en överavkastning i förhållande till OMXSPI på svenska handelsplatser under en börsuppgång och en börsnedgång för olika tidsintervall och branscher. Studien har undersökt nyintroduktioner genomförda under tidsperioden Q1 2004 till Q2 2009. Syftet har för avsikt att utmynna i huruvida nyintroduktioner vid svenska handelsplatser är effektiva och om investerare kunnat utnyttja eventuella ineffektiviteter som investeringsstrategier. Undersökningen är en eventstudie baserad på en kvantitativ metod där korrigerade historiska aktiekurser har inhämtats och beräkningar har genomförts med hjälp av två metoder, den genomsnittliga abnormala avkastningen och den genomsnittliga abnormala avkastningen för en buy-and-hold strategi, för att säkerställa en hög validitet i studien. Slutsatsen påvisar att investerare som investerat i nyintroduktioner på AktieTorget under börsuppgången hade kunnat utnyttja den något lägre grad av effektivitet utifrån en buy-andhold strategi på tre månader och erhållit en genomsnittlig signifikant överavkastning gentemot OMXSPI på 32,6 procent. En investerare som valt att investerare i nyintroduktioner utifrån en buy-and-hold period på tre månader på Alternativa Aktiemarknaden under börsnedgången hade i genomsnitt erhållit en signifikant överavkastning på 11,8 procent. För den investeraren som inte tagit hänsyn till när introduktionen genomförts och investerat i nyintroduktioner på AktieTorget utifrån en buy-and-hold period på en månad hade i genomsnitt erhållit en signifikant överavkastning på 18,2 procent.
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Monteiro, Samuel Godinho. "Características de desempenho do MPGD THCOBRA a operar em Ar/CH4." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16573.
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Mestrado em Tecnologias da Imagem MédicaOs detetores de radiação representam um dos componentes principais dos equipamentos de imagiologia, tendo como principal função o registo da intensidade do feixe de raios X após atenuação, fundamental para a posterior criação da imagem. Desde o desenvolvimento da película radiográfica, a evolução dos detetores de radiação tem sido progressiva, implementando-se diferentes materiais e técnicas na deteção de raios X com o objetivo de produção de imagens mais eficiente, com maior qualidade, reduzido tempo de exposição e menor dose de radiação no paciente. O detetor gasoso microestruturado (MicroPattern Gaseous Detector – MPGD) baseado na estrutura Thick-COBRA (THCOBRA) já mostrou, como publicado na literatura, as suas potencialidades em imagiologia por transmissão de raios X. Apesar disto, e olhando ao facto de este ser um detetor desenvolvido recentemente, não existem estudos quanto às suas características de desempenho. Daí levanta-se a seguinte questão problema que impulsionou este trabalho: “Quais são as características de desempenho de um MPGD baseado na THCOBRA?”. O objetivo do trabalho é então estudar as características de desempenho do MPGD THCOBRA a operar em Ar/CH4 (95/5) para imagiologia por transmissão de raios X, avaliando os parâmetros de resolução espacial, a Modulation Transfer Function (MTF), o Noise Power Spectrum (NPS), Detective Quantum Efficiency (DQE), ganho em carga, resolução em energia, uniformidade e relação sinal ruído (SNR). Serão ainda exploradas as potencialidades deste detetor, usando a informação em energia para obter diferentes tipos de imagem. O estudo foi realizado no laboratório do grupo de Deteção de Radiação e Imagiologia Médica (DRIM) do I3N sediado no Complexo Interdisciplinar de Ciências Físicas Aplicadas à Nanotecnologia e à Oceanografia (CICFANO) da Universidade de Aveiro, com recurso a uma ampola de raios X e um MPGD com a estrutura THCOBRA. Para estudar as características de desempenho do detetor, foram adquiridos os dados necessários em laboratório e de seguida avaliado cada um dos parâmetros de qualidade com base nos métodos existentes na literatura, adaptados para este caso concreto, visto não existirem métodos específicos para o detetor em causa. Tendo como base a literatura já publicada sobre este detetor, são limitadas as previsões acerca dos resultados esperados das características de desempenho, tendo-se conhecimento de que estes serão inferiores aos detetores de radiação usados atualmente em imagiologia. Os resultados obtidos estiveram de acordo com as previsões, mas além disso revelam que este detetor tem potencialidades para criação de imagens por transmissão cuja qualidade pode ser otimizada futuramente.
Radiation detectors are one of the main components of imaging equipment, having the main function of registering the intensity of X-ray beam after attenuation, fundamental for the subsequent creation of the image. Since the development of radiographic film, the evolution of the radiation detectors has been progressive, by implementing different materials and techniques on the X-rays detection with the purpose of more efficient production of images with higher quality, reduced time of exposure and lower radiation dose in the patient. Micro Pattern Gaseous Detector (MPGD) based on Thick-COBRA structure (THCOBRA) has shown, as published in the literature, its potential for imaging by X-ray transmission. Despite this, and looking at the fact that this is a newly developed detector, there are no studies as to its performance characteristics. From there arises the question problem which boosted this work: "Which are the performance characteristics of a MPGD based on a THCOBRA?". This study aims to examine the performance characteristics of MPGD THCOBRA operating in Ar/CH4 (95/5) for imaging by X-ray transmission, evaluating the parameters of spatial resolution, Modulation Transfer Function (MTF), Noise Power Spectrum (NPS), Detective Quantum Efficiency (DQE), charge gain, energy resolution, uniformity and signal noise ratio (SNR). Also, will be explored the potential of this detector, using energy information to achieve different types of images. The study was conducted in the laboratory of Radiation Detection and Medical Imaging Group (DRIM) of I3N in the CICFANO at University of Aveiro, using an X-ray tube and a MPGD with a THCOBRA structure. To examine the detector performance characteristics the necessary data was acquired in the laboratory and then evaluated each quality parameter based on existing methods in the literature, adapted for this case, since there are no specific methods for the involved detector. Based on the published literature about this detector, the predictions are limited regarding the expected results of the performance characteristics, having knowledge that these will be lower than the radiation detectors currently used in medical imaging. The results were in line with the predictions, but additionally shown that this detector has the potential to create transmission images whose quality can be improved in the future.