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1

Weichhart, Thomas, ed. mTOR. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-430-8.

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2

Polunovsky, Vitaly A., and Peter J. Houghton, eds. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-271-1.

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3

Houghton, Peter J., and V. A. Polunovskiĭ. mTOR pathway and mTOR inhibitors in cancer therapy. Humana Press, 2010.

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4

Dey, Nandini, Pradip De, and Brian Leyland-Jones, eds. PI3K-mTOR in Cancer and Cancer Therapy. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34211-5.

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5

Mita, Monica, Alain Mita, and Eric K. Rowinsky, eds. mTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer Paris, 2016. http://dx.doi.org/10.1007/978-2-8178-0492-7.

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6

Transportation, Ontario Ministry of. MTO drainage management manual. Ministry of Transportation, 1995.

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7

Ontario. Ministry of Transportation. Road User Safety Division, ed. The Official MTO Driver's Handbook. Road User Safety Division, Ministry of Transportation, 2015.

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8

Associates, R. V. Anderson, and Ontario Ministry of Transportation, eds. MTO drainage management technical guidelines. Highway Design Office, Highway Engineering Division, Ontario Ministry of Transportation, 1989.

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9

Ontario. Ministry of Transportation. Road User Safety Division. The official MTO motorcycle handbook. Road User Safety Division, Ministry of Transportation of Ontario, 2012.

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10

Karekin. "Khorhē ew mtir--": Khoher ew hayeatsʻkʻner dprevankʻi masin. [s.n.], 1995.

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11

ller-Philipp, Susanne Mu. Leitfaden Geometrie: Fu r Studierende der Lehra mter. 5th ed. Vieweg + Teubner, 2012.

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12

Vegesack, Thomas von. Iakttagelser vid grnsen: Nr sknlitteraturen mter sina vedersakare. Natur och Kultur, 2002.

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13

Mayya, Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Sāhitya Prakāśana, 2009.

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Mayya, Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Sāhitya Prakāśana, 2009.

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Mayya, Pi Sadānanda. Savijīvana: Eṃ. Ṭi. Ār. Sadānanda Mayyara sādhanākathana. Sāhitya Prakāśana, 2009.

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16

Ontario. Ministry of Transportation. Licensing and Control Branch. The official MTO motorcycle handbook: Get the latest updates! Road User Safety Division, Ministry of Transportation of Ontario, 2007.

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17

Chattle, M. V. Intercomparison of gallium sealed cells: BCR project MTR-38. Commissionof the European Communities, 1985.

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18

Molesworth, Carl. P-40 warhawk vs Bf 109: Mto 1942-44. Osprey, Publishing, 2011.

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19

Ontario. Ministry of Transportation. Road User Safety Division. The official MTO bus handbook: Get the latest updates! Road User Safety Divison, Ministry of Transportation of Ontario, 2007.

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20

Rapamycin: MTOR, Autophagy and Treating MTOR Syndrome. Praktikos Books, 2023.

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21

Pelton, Ross. Rapamycin: Rapamycin, MTOR, Autophagy and Treating MTOR Syndrome. Praktikos Books, 2022.

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22

Houghton, Peter J., and Vitaly A. Polunovsky. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Humana, 2012.

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23

mTOR in Human Diseases. MDPI, 2019. http://dx.doi.org/10.3390/books978-3-03921-061-9.

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24

Choo, Andrew Yoon. mTOR, metabolism, and cancer. 2009.

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25

Weichhart, Thomas. mTOR: Methods and Protocols. Humana Press, 2016.

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26

mTor: Methods and protocols. Humana Press, 2012.

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27

Molecules to Medicine with mTOR. Elsevier, 2016. http://dx.doi.org/10.1016/c2014-0-03321-7.

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28

Pelton, Ross. Rapamycin, MTOR, Autophagy and Treating MTOR Syndrome: Rapamycin the Most Promising Life Extension Drug. Praktikos Books, 2022.

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29

Pelton, Ross. Rapamycin, MTOR, Autophagy, & Treating MTOR Syndrome : Rapamycin: The World's Most Promising Life Extension Drug. FreshLife Media, 2022.

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30

Rapamycin, MTOR, Autophagy and Treating MTOR Syndrome: Rapamycin, the Most Promising Life Extension Drug. Praktikos Books, 2023.

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31

mTOR Signaling in Metabolism and Cancer. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03943-554-8.

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32

Arcaro, Alexandre, ed. Targeting PI3K/mTOR signaling in cancer. Frontiers Media SA, 2014. http://dx.doi.org/10.3389/978-2-88919-244-1.

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33

Huang, Shile. mTOR Signaling in Metabolism and Cancer. Mdpi AG, 2020.

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34

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-mTOR in Cancer and Cancer Therapy. Humana, 2016.

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35

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-mTOR in Cancer and Cancer Therapy. Humana, 2018.

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36

Leyland-Jones, Brian, Nandini Dey, and Pradip De. PI3K-MTOR in Cancer and Cancer Therapy. Humana Press, 2016.

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37

Regulatory mechanisms in the Akt-mTOR signalings axis. 2009.

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38

Kramer, Carolyn, and Emily Blumberg. Immunosuppressants and Antiretroviral Therapy in HIV-Positive Transplant Patients. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0028.

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Protease inhibitors (PIs), especially ritonavir, are inhibitors of CYP3A4 and P-gp1 and can significantly increase levels of calcineurin inhibitors and mammalian target of rapamycin (mTOR) inhibitors. Cobicistat is an inhibitor of CYP3A4, and its effect on levels of calcineurin inhibitors and mTOR inhibitors is likely to be similar to that of ritonavir. Efavirenz may result in lower concentrations of calcineurin inhibitors and mTOR inhibitors. Dose reduction and careful attention to monitoring drug levels are critical to avoid toxicity and maintain therapeutic immunosuppressive concentrations
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39

Mita, Monica, Alain Mita, and Eric K. Rowinsky. MTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer London, Limited, 2015.

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40

Mita, Monica, Alain Mita, and Eric K. Rowinsky. mTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer, 2016.

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41

mTOR Inhibition for Cancer Therapy: Past, Present and Future. Springer, 2015.

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42

Krueger, Darcy A., and Jamie Capal. Familial CNS Tumor Syndromes. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0136.

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Tuberous sclerosis complex is an autosomal dominant multi-system disease that involves the skin, brain, heart, lungs, and kidneys and is associated with seizures including infantile spasms, intellectual disability, autism and pulmonary and heart disease. Skin lesions can be particularly disfiguring and infantile spasms can be associated with marked cognitive decline. The outlook for patients has improved markedly with the recognition that TSC is caused by upregulation of the mammalian target of rapamycin (mTOR) enzyme, which connects energy needs and supply with cellular and neuronal growth. m
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43

Maiese, Kenneth. Molecules to Medicine with MTOR: Translating Critical Pathways into Novel Therapeutic Strategies. Elsevier Science & Technology Books, 2016.

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44

Birle, Diana C. Interactions between inhibitors of mTOR and EGFR/ERK signaling in SiHa cervical carcinoma. 2004.

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45

Weiner, Howard, and Peter B. Crino. Familial tumour syndromes: tuberous sclerosis complex. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0017.

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Tuberous sclerosis complex (TSC) is a multisystem, genetic disorder that results from mutations in TSC1 or TSC2 genes. Neurological and neuropsychiatric disabilities include epilepsy, intellectual disability, autism, attention deficit disorder, and generalized anxiety. Cortical dysplasias (also known as tubers) are developmental abnormalities of the cerebral cortex that are believed to be responsible for seizures, cognitive disability, and autism. Subependymal giant cell astrocytomas (SEGAs) are intraventricular tumours that can cause hydrocephalus, increased intracranial pressure, and death.
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46

Land, Siim. Metabolic Autophagy Cookbook: Eat Foods That Boost Autophagy, Balance MTOR for Longevity, and Build Muscle. Independently Published, 2019.

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47

Maiese, Kenneth. Molecules to Medicine with MTOR: Translating Critical Pathways of the Mammalian Target of Rapamycin into Novel Therapeutic Strategies. Elsevier Science & Technology Books, 2016.

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48

Z.Y. Luo, Q. Song, X.P. Xiong, et al. The PI3K/Akt/mTOR signaling pathway regulates lipid metabolism mediated by endoplasmic reticulum stress in goose primary hepatocytes. Verlag Eugen Ulmer, 2021. http://dx.doi.org/10.1399/eps.2021.325.

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49

Co, Anderson Publishing. Anderson's 2014 Ohio Traffic Law Handbook: Covering Title 45, the Ohio Mtor Vehicles Law, As Maended by the Ohio General Assembly. Anderson Pub Co, 2013.

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50

Wong, Han Hsi, Basma Greef, and Tim Eisen. Treatment of metastatic renal cancer. Edited by James W. F. Catto. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0089.

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Metastatic renal cancer is resistant to standard chemotherapy. Although some patients with indolent disease can be initially managed with observation, the majority of patients will require aggressive treatment soon after diagnosis. Options include cytoreductive nephrectomy, resection of a solitary metastasis in highly selected cases, or systemic therapy options. The TKIs sunitinib and pazopanib are currently the first-line treatments of choice. Whilst axitinib and cabozantinib have important roles in the second line the PD-1 checkpoint inhibitor, nivolumab, is now established as standard secon
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