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Bouloubasis, Antonios K. "The MTR, a multitasking rover." Thesis, University of Reading, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515703.
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孫奮生 and Fun-sing Winston Suen. "A promotional strategy for the MTR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1985. http://hub.hku.hk/bib/B31263410.
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Mouratoglou, Andrés. "Reestructuración en metalúrgica MTR Argentina SRL." Bachelor's thesis, Universidad Nacional de Córdoba Facultad de Ciencias Exactas, Físicas y Naturales Escuela de Ingeniería Industrial, 2016. http://hdl.handle.net/11086/2747.
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Proyecto Integrador (II)--FCEFN-UNC, 2016<br>Propone el diseño de herramientas y genera conocimientos útiles para la empresa MTR Argentina SRL mediante un trabajo de reingeniería a fin que la empresa sea más eficiente en su unidad productiva y un proveedor de calidad para sus clientes.
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Suen, Fun-sing Winston. "A promotional strategy for the MTR /." [Hong Kong : University of Hong Kong], 1985. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12317202.
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Tok, Mehtap, and Yasemin Gül. "Hur de anställda ser på företagskulturen inom MTR Stockholm." Thesis, Södertörns högskola, Institutionen för samhällsvetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-24245.
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Problem: The great interest towards the company’s values has contributed to it becoming more common for individuals to seek out organizations that have a strong corporate culture. Where you work and whom you work for has thus become the dominant factors instead of what you are working with. Purpose: The purpose of this study is to examine how the corporate culture, the rational and emotional benefits are experienced by the employees of the company. The aim is also to examine whether the corporate culture can become a management control measure by good communication between employees within the organization. Methodology: The essay is based on a qualitative research method and empirical data were collected through interviews from the company MTR Stockholm. Theoretical Frame of reference, Edgar Schein, Three Levels of Culture, Seven dimensions. Results: The study has shown that there are different cultures within the company. But also that there is a strong corporate culture within the business, the respondents feel an affinity with working within the underground rather than working for the company MTR Stockholm.
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SIMOES, ANGELA V. "Desempenho sob irradiacao de combustiveis a dispersao de MTR." reponame:Repositório Institucional do IPEN, 1993. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10332.
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Chan, Tat-tai. "The competition between buses and the MTR in Hong Kong." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B31945429.
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陳達大 and Tat-tai Chan. "The competition between buses and the MTR in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31945429.
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Cheng, Hon-keung, and 鄭漢強. "Options for improving the existing MTR network in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31945417.
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Tam, Yuen-chi, and 譚遠志. "The effectiveness of the safety management system on the MTR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B4257514X.
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Tam, Yuen-chi. "The effectiveness of the safety management system on the MTR." Click to view the E-thesis via HKUTO, 2000. http://sunzi.lib.hku.hk/hkuto/record/B4257514X.
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Cheng, Hon-keung. "Options for improving the existing MTR network in Hong Kong." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23339032.
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關尚豪 and Sheung-ho Chevrio Kwan. "Mongkok crossing: a kinetic citywalk-briding two stations : KCR & MTR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31986535.
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Yuen, Wing-yiu, and 袁頴瑤. "Recommendation for railway planning in Hong Kong: merging MTR and KCR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42576635.
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Yuen, Wing-yiu. "Recommendation for railway planning in Hong Kong merging MTR and KCR /." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B42576635.
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Yuen, Wing-yu. "Recommendation for railway planning in Hong Kong : merging MTR and KCR /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25248467.
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Kwan, Sheung-ho Chevrio. "Mongkok crossing : a kinetic citywalk-briding two stations : KCR & MTR /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25953357.
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Wan, Shing-fun Billy. "Is railway the only element that adds value to the MTR properties? /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38027343.
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Wan, Shing-fun Billy, and 溫承勳. "Is railway the only element that adds value to the MTR properties?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45009077.
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Groenewald, Suzanne Anél. "Reflector modelling of MTR cores making use of normalised generalised equivalence theory." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9054.
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This research focuses on modelling reflectors in typical material testing reactors (MTRs). Reflectors present some challenges to the usual approach to full-core calculational models. Diffusion theory is standardly used in full-core calculations and is known to be inaccurate in regions where the flux is anisotropic, for example within the reflectors. Thus, special consideration should be given to reflector models. In this research, normalised generalised equivalence theory is used to homogenise cross-sections and calculate equivalent nodal parameters and albedo boundary conditions for the reflector surrounding a typical MTR reactor. Various studies have shown that equivalence theory can be used to accurately generate equivalent nodal parameters for the core and reflector regions of large reactors, such as pressurised and boiling water reactors, in one dimension and for two neutron energy groups. This has not been tested for smaller reactors where leakage, environment sensitivity and multi-group spectrum dependency are much larger.
The SAFARI-1 MTR reactor is modelled in this work. A thirty day operational cycle is simulated for this reactor, using the nodal diffusion code MGRAC. NGET reflector equivalent nodal parameters are calculated using the codes NEWT and EQUIVA. The impact of different reflector models are evaluated, based on their effect on the core power, flux distribution, reactivity and neutron leakage over the duration of the operational cycle.
It is found that homogenisation introduces some environment dependencies in the reflector parameters, particularly in the corners of the reactor core. In full-core calculations, the reflector parameters show some sensitivity to the in-core reflector structures, but not the fuel composition. A practical reflector model for SAFARI-1 is proposed, which proves that NGET equivalence theory can be used for multi-group reflector modelling in a small MTR reactor. This approach to reflector modelling simplifies the core model, increases the accuracy of a diffusion calculation, and increases the efficiency (shorter calculational time and better convergence behaviour) of computer simulations.<br>Thesis (MSc (Engineering Sciences in Nuclear Engineering))--North-West University, Potchefstroom Campus, 2013.
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Nikola, Đurić. "Dekodovanje MTR kodova principom finog odlučivanja na kanalima za magnetsko memorisanje informacija." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2009. http://dx.doi.org/10.2298/NS20091120DJURIC.
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U radu su predstavljene nove tehnike dekodovanja maximumtransition run (MTR) kodova na principu finog odlučivanja.Analizirane su performanse ovih tehnika u kombinaciji sazaštitnim LDPC kodom na kanalima za magnetsko memorisanjeinformacija, sa posebnim osvrtom na model kanala sadve staze za zapisivanje i dve glave za čitanje. U modelu kanalaje korišćena idealna E2PR4 ekvalizacija staza adekvatnaza sisteme sa visokom gustinom magnetskog zapisa.<br>This thesis presents the novel soft-decision decoding techniquesfor decoding of the maximum transition run (MTR)codes. Performances of such techniques have been analyzedin combination with error correcting LDPC code over magneticrecording channels, especially the two-track two-headchannel model. Ideal E2PR4 track equalization suitable forhigh density magnetic recording has been used.
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Durazzo, Michelangelo. "Corrosão de placas combustíveis tipo MTR contendo núcleos de cermets U3O8-Al." Universidade de São Paulo, 1986. http://www.teses.usp.br/teses/disponiveis/85/85132/tde-25062012-094540/.
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Foram fabricadas amostras de placas combustíveis contendo núcleos de cermets U3O8-Al com concentrações de U3O8 variando de 10 a 90% em peso (3,4 a 55,5% em volume). Amostras contendo núcleos com 58% em peso de U3O8, foram fabricadas a partir de compactados com densidades variando de 75 a 95% da densidade teórica. É discutida a influência da concentração de U3O8 e da porosidade do compactado de partida sobre a porosidade e uniformidade da espessura do núcleo obtido. Os núcleos U3O8-Al foram submetidos a ensaios de corrosão por água deionizada nas temperaturas 30, 50, 70 e 90°C, onde os núcleos foram expostos através de um defeito artificial produzido no revestimento. Os resultados obtidos mostram que a corrosão dos núcleos é acompanhada pela liberação de hidrogênio. O volume total de hidrogênio liberado (V) e o tempo transcorrido até que seja observado o início da liberação de hidrogênio (tempo de incubação ti, são dependentes da porosidade do núcleo e da temperatura absoluta (T), podendo ser descritos pelas equações: V = K1 eα1 P - K2 T eα2 P e ti = eK1 + K2 P + K3 / T + K4 P / T onde P é a fração volumétrica de vazios (porosidade) e K1, K2, K3,K4, α1 e α2 são constantes. É proposto e discutido um mecanismo para o processo de corrosão de núcleos U3O8-Al. O revestimento das amostras de placas combustíveis foi submetido a ensaios de corrosão sob condições similares às encontradas no reator IEA-R1 operando às potências de 2 MW, 5 MW e 10 MW. Foi verificado o efeito da presença de heterogeneidades superficiais e de um tratamento de limpeza química sobre o comportamento da corrosão do revestimento. Os resultados obtidos mostram que a corrosão é regulada pela dissolução/erosão da camada de óxido formada e segue lei linear para as três condições de testes e que a presença de heterogeneidades superficiais ou o tratamento de limpeza química não alteram significativamente a corrosão do revestimento para tempos de exposição de até 20 dias. Estão apresentadas as velocidades de corrosão e as espessuras das camadas de óxido observadas nos três ensaios efetuados. Não foi observado ataque localizado significativo.<br>Fuel plate specimens containing U3O8-Al cermet cores were fabricated with the U3O8 concentration varying between 10 and 90% by weight (3.4 to 55.5% in volume). Fuel plate specimens containing 58% U3O8 by weight were also fabricated from compacts with densities varying between 75 and 95% of the theoretical density. The influence of U308 concentration and porosity of the initial compact on the porosity and uniformity of thickness of the core are discussed. The U3O8-Al cores were corrosion tested in deionized water at 30, 50, 70 and 90°C, where in the cores were exposed to the deionized water by means of an artificially produced cladding defect. The results indicate that core corrosion is accompanied by hydrogen evolution. The total volume of hydrogen evolued (V) and the time to initiation of hydrogen evolution (incubation time ti), vary with the porosity of the core and temperature (T), according to equations: V = K1 eα1 P - K2 T eα2 P e ti = eK1 + K2 P + K3 / T + K4 P / T where P is the volumetric fraction of pores and K1, K2, K3,K4, α1 e α2, are constants. A mechanism for the U3O8-Al core corrosion has been proposed and discussed. The cladding of the fuel plats specimens was also corrosion tested under conditions similar to those encountered in the IEA-R1 reactor operating at 2, 5 and 10 MW. The effect of the presence of surface heterogeneities and a chemical surface treatment on the corrosion behavior of the cladding have been studied. The results reveal that the corrosion is regulated by dissolution/erosion of the oxide layer, and follows a linear law under the three test conditions. The presence of surface heterogeneities or the chemical surface treatment did not significantly alter the cladding corrosion for test times of up to 20 days. The corrosion rates and the oxide layer thicknesses observed under the three test conditions are also presented. No significant localized attack was observed.
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DURAZZO, MICHELANGELO. "Corrosao de placas combustiveis tipo MTR contendo nucleos de cermets U3O3-Al." reponame:Repositório Institucional do IPEN, 1985. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9858.
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Raun, Michael. "Sensor based system for train detection : Master thesis for MTR in Mechatronics." Thesis, KTH, Maskinkonstruktion (Inst.), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168704.
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Tunnelbanan i Stockholm består av tre linjer, som omfattar 100 stationer med 108 km spår. Resenärer gör 1,1 miljoner resor varje dag. Beroende av tid på dygnet kan antalet tågvagnar variera, vilket kan leda till att föraren av misstag stoppar tåget med en vagn kvar i tunneln eller utanför plattformen. För att förhindra detta behövs ett sensorbaserat fristående system som indikerar till föraren att hela tåget är vid plattformen. Först beskriver denna avhandling de befintliga tekniker och metoder som används för tågdetektering idag. Två typer av teknik jämförs för denna applikation, optiska och induktiva. Det optiska systemet är dyrare och är känslig för en stökig och smutsig miljö, men är enkelt applicerbart på denna applikation. Den induktiva sensorn är billig och kräver inget underhåll. Utmaningen är det korta avkänningsavståndet på 50 mm. De båda typerna av sensorerna testas i ett system, i laboratoriemiljö och vid Hjulsta tågstationen. Olika typer av konfigurationer testas och utvärderas. De två konfigurationer som jämförs i slutet, är ett lasersensor system som indikerar för föraren när laserstrålen är blockerad. Den andra konfigurationen använder två induktiva sensorer som räknar tågets axlar på två olika platser längs spåret. Ett schema för det slutliga kretskortet och kod för logiken presenteras avslutningsvis.<br>The metro system in Stockholm consists of three lines, covering 100 stations with 108 km of track. Boarding passengers take 1.1 million journeys every day. Depending on the time of day, the number of cars varies, which can cause drivers to inadvertently stop trains with one car still in the tunnel or off the platform. To prevent this, there is a need for a sensor-based stand-alone system to alert drivers that the whole train, including all cars, is at the platform. First, the thesis describes the existing technologies and methods for train positioning. Two types of technology are compared for this application, optical and inductive. The optical system is more expensive and more sensitive to a messy environment but is more straightforward. The inductive sensor is cheap and does not need any maintenance. The challenge is the 50 mm sensing range. Both types of sensors were tested in a system, in laboratory environment and at Hjulsta trainstation. Different approaches were tested and evaluated. The two configurations that are compared in the end are a laser sensor system that indicates to the driver when the laser beam is blocked. The second configuration uses two inductive sensors that count the axles in two different locations along the track. Schematics for the final PCB and code for the logic are also presented.
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Fan, Xiaowei, and 范晓威. "Evaluating pedestrian friendliness for MTR stations and surrounding built environment in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206547.
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The performance of railway service influences the living qualities of people in Hong Kong. This dissertation is a study to discover the pedestrian friendliness of R+P Stations and Non R+P Stations with different backgrounds. MTR stations that surveyed include two R+P Stations in new generation (Kowloon Station and Tsing Yi Station), one R+P Station in old generation (Tsuen Wan Station) and one Non R+P Station (Tsim Sha Tsui Station).
A roadway characteristic-based PLOS model that following point system of analyzing is developed based on the requirements of planning and design standards in Hong Kong. From the data result, pedestrian walking environment of existing MTR stations have good quality in general. Factors that influence the overall pedestrian friendliness of MTR station catchments area include the construction time of the station, development time for streets the sidewalks along and number of walkways connecting to R+P properties the station have. Advantages and disadvantages of walking environment of each station are discovered. Recommendations for building a more pedestrian friendly city of Hong Kong are given based on the data results. Recommendations include quantification of the design standards, future works to solve the existing walking problems and encouraging more R+P Stations and urban renewal projects.<br>published_or_final_version<br>Urban Planning and Design<br>Master<br>Master of Science in Urban Planning
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Gjordeni, Kejsi, and Ayca Kaya. "Digitizing the Maintenance Management Operation : Exploring the Opportunities of an Information System in a Railway Maintenance Organization." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-264090.
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The phenomenon of digitization is transforming industries worldwide by introducing new valueproducing opportunities. In the railway industry, market liberalization has resulted in increased competition. To remain profitable in this new market environment, rail operators need to transform and acquire new digital capabilities and tools. By digitizing information-intensive processes with an information system, railway companies can reduce loss of operation time and reduce total maintenance costs. At the same time, the limited research exploring information systems in maintenance management has made it challenging for companies wanting to digitize. Significant attention has been devoted to the separate topics, however research overlapping the two areas of study has been inadequate. The thesis aims to contribute with knowledge to bridge this gap in literature by investigating the opportunities a maintenance organization potentially can capture with an information system and the success factors needed to succeed. By conducting the thesis in collaboration with the Swedish railway maintenance company MTR Tech AB the potential uses of an information system have been identified and assessed. Findings indicate that there are three main business opportunities to obtain from an information system: support of the troubleshooting process, better planning of reactive maintenance and enabling the performance of condition-based maintenance. At the same time, the profitability of an information system was found to be directly linked to its degree of utilization. Our findings have therefore allowed us to conclude that the business opportunity to pursue is the one that is most likely to be carried out fully and successfully in the prevailing circumstances. Lastly, the findings conclude that the success factors needed to capture the desired business opportunities are a dedicated project group, clear communication and information sharing, as well as adequate personnel.<br>Digitalisering har påverkat och transformerat företag över hela världen genom att erbjuda nya värdeproducerande möjligheter. För att bibehålla konkurrenskraft i en föränderlig omvärld måste järnvägsoperatörer transformera sina företag och förvärva nya digitala lösningar och verktyg kopplade till järnvägsteknologier. Genom att digitalisera informationsintensiva processer med hjälp av informationssystem, blir det möjligt för järnvägsföretag att minska förlust av drifttid samt minska den totala underhållskostnaden. Samtidigt har den begränsade forskningen gällande användning av informationssystem i underhållsorganisationer försvårat digitaliseringsförsöken. Litteratur och tidigare studier har behandlat de två ämnena separat, dock har överlappande forskning varit otillräcklig. Denna studie syftar till att bidra med kunskap för att överbrygga gapet i litteraturen genom att undersöka de vinningar en underhållsorganisation kan erhålla med hjälp av ett informationssystem och de framgångsfaktorer som krävs för att uppnå dem. Genom att utföra denna studie i samarbete med det svenska underhållsbolaget MTR Tech AB har de potentiella användningsområdena av ett informationssystem identifierats. De tre huvudsakliga affärsmöjligheterna som kan erhållas från ett informationssystem är: stödjande av felsökningsprocessen, bättre planering av avhjälpande underhåll, samt möjliggörandet av tillståndsbaserat underhåll. Samtidigt har det visat sig att lönsamheten av ett informationssystem är direkt kopplat till dess utnyttjandegrad. Vi har således dragit slutsatsen att den affärsmöjlighet som bör eftersträvas är den som med största sannolikhet kommer att genomföras framgångsrikt under rådande omständigheter. Slutligen visar våra resultat att de framgångsfaktorer som krävs för att uppnå affärsmöjligheterna är en dedikerad projektgrupp, tydlig kommunikation och informationsdelning, samt lämplig personal.
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Kwok, Ka-ho. "Bus-rail co-ordination a case study of MTR feeder buses in Hong Kong /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38347684.
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Silva, Fernanda Amorim Gomes da. "Avaliação temporal e espacial da expressão das metaloproteinases de matriz tipo de membrana (MT2, MT3, MT4, MT5 e MT6-MMP) durante a ossificação endocondral em camundongos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-09112010-105227/.
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As MMPs são endopeptidases zinco dependentes que, em conjunto, podem degradar todos os componentes da MEC e gerar moléculas bioativas. São as principais responsáveis pelo remodelamento tecidual durante eventos fisiológicos normais como a embriogênese e organogênese e também em eventos patológicos como a invasão tumoral nos tecidos. As pesquisas na área de mineralização biológica têm buscado identificar os genes envolvidos nos mecanismos moleculares que regula o processo de ossificação endocondral. As MMPs e seus inibidores são responsáveis pelo controle da degradação desta matriz, como os inibidores teciduais das MMPs (TIMPs) e a proteína RECK, que, muito provavelmente, determinam o grau de remodelação da matriz extracelular. Desta forma, nosso objetivo foi delinear o perfil temporal e espacial da expressão das MMP-15/MT2-MMP, MMP-16/MT3- MMP, MMP-17/MT4-MMP, MMP-24/MT5-MMP e MMP-25/MT6-MMP durante a ossificação endocondral em embriões de camundongos e em animais recémnascidos através das técnicas de PCR em tempo real e imunohistoquímica. Por imunohistoquímica, nós não encontramos imunomarcação para a MMP-15/MT2- MMP em nenhum dos períodos analisados, apesar da padronização do anticorpo primário. Tanto a MMP-16/MT3-MMP quanto a MMP-24/MT5-MMP foram imunolocalizadas, principalmente, nos osteoblastos do fronte de ossificação da placa de crescimento. Para a MMP-17/MT4-MMP, durante a diferenciação condrocítica (E13) os condrócitos proliferativos foram imunocorados, bem como os condrócitos hipertróficos no centro da cartilagem do molde cartilaginoso (E14). Durante a invasão celular e vascular (E15), as células mesenquimais oriundas do colar ósseo, provavelmente pré-osteoblastos, foram imunocorados na cavidade medular primitiva e osteoblastos fronte de ossificação foram imunocorados, de E16 a PN1. Observamos para a MMP-25/MT6-MMP o mesmo padrão de imunomarcação das demais MT-MMPs, exceto no molde cartilaginoso, onde apenas as células do periósteo e pericôndrio foram imunocoradas, diferentemente da demais que foram localizadas apenas no centro do molde cartilaginoso. A análise da expressão dos transcritos para todas as MT-MMPs revelou o mesmo perfil de expressão, sendo alta durante a fase de diferenciação condrocítica (E13), tendo queda de expressão de E14 a E16. Em E16 há um aumento de expressão até E18 e, novamente, queda até E20 e pouca ou nenhuma expressão em PN7. Apesar deste perfil semelhante, houve uma expressão diferencial entre elas, sendo a MMP-15/MT2-MMP > MMP- 17/MT4-MMP > MMP-16/MT3-MMP > MMP-24/MT5-MMP > MMP-25/MT6/MMP. Os resultados obtidos mostram, pela primeira vez, que as MT-MMPs estão diferencialmente expressas durante a ossificação endocondral normal em camundongos, sugerindo que a atividade biológica destas enzimas esteja atuando na degradação da matriz extracelular pericelular tanto durante a fase de desenvolvimento quanto de formação óssea.<br>MMPs are zinc-dependent endopeptidases that, collectivelly, degrade all components of the ECM and generate bioactive molecules. They are able to remodelate the ECM during normal developmental processes such as embryogenesis and organogenesis, as well as in pathological processes such as tumoral invasion. The biological mineralization research looking for discovering the genes involved in the molecular mechanisms that control the endochondral ossification process. MMPs and their inhibitors (TIMPs and RECK) are responsable for bone matrix remodeling and, probably, determinate the level of its turnover. Thus, our goal was to evaluate the temporal-spatial expression of MMP-15/MT2-MMP, MMP-16/MT3-MMP, MMP-17/MT4-MMP, MMP-24/MT5-MMP, and MMP-25/MT6- MMP in mice embryos and newborns during endochondral ossification by Real Time PCR and immunohistochemistry. By immunohistochemistry, MMP-15/MT2-MMP signal was not detected. Both MMP-16/MT3-MMP and MMP-24/MT5-MMP were immunostained, mainly in osteoblasts at ossification front of growth plate. For MMP- 17/MT4-MMP, proliferative chondrocytes were immunopositive during chondrocyte differentiation (E13) as well as in hipertrophyc chondrocytes at the middle of cartilaginous template (E14). During cellular e vascular invasion (E15), mesenchymal cells from bone collar, probable pre-osteoblasts, were immunostained at primary bone marrow and osteoblasts at ossification front from E16 e PN1. For MMP- 25/MT6-MMP, perichondrial and periostal cellls were immunostained at cartilaginous template. All MT-MMPs evaluated showed the same transcript levels profile, being high in chondrocyte differentiation (E13), decreasing from E14 to E16. mRNA levels increased from E16 to E18 and, once more, decreasing from E18 to E20. Despite this profile, we observed difference levels: MMP-15/MT2-MMP > MMP-17/MT4-MMP > MMP-16/MT3-MMP > MMP-24/MT5-MMP > MMP-25/MT6/MMP. Our findings show, for the first time, that MT-MMPs are differentially expressed during normal endochondral ossification in mice, suggesting their biological activity act in pericellular extracellular matrix degradation in both development and bone formation.
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Biselli, Patricia Matos. "Poliformismos dos genes VEGF, MTHFR e MTR e fatores de risco na doença arterial coronária." Faculdade de Medicina de São José do Rio Preto, 2006. http://bdtd.famerp.br/handle/tede/12.
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Previous issue date: 2006-11-13<br>Coronary atherosclerosis results from interaction among environmental and genetic risk factors. In this sense, the objective of this study was to investigate the frequencies of VEGF gene polymorphisms, related to the development of new vessels, and of MTHFR e MTR genes polymorphisms, involved in the homocysteine metabolism (Hcy), associated to the formation of atherosclerosis lesions, in 175 patients with coronary artery disease (CAD) and 108 control individuals with no angiographic signs of the disease. Plasma Hcy, folate and methylmalonic acid (MMA), besides micronutrients ingestion required for Hcy metabolism were also analyzed. The risk factors for DAC were arterial hypertension (P=0.021), diabetes (P=0.029), smoking (P=0.006) and HDLc levels<40 mg/dL (P=0.0003). The altered VEGF -2578CC genotype was observed in higher frequency in patients with three damaged arteries (P=0.008). MTHFR 1298AA genotype was associated with decreased folate levels in the group with CAD (P=0,010). MMA mean levels were significantly higher in the group with CAD in relation to the control (P=0.048). Vitamin B12 deficiency was more frequently observed in CAD group (P=0,004). A positive correlation among MMA levels and Hcy concentrations was observed in the group with CAD (P=0.001), as well as in the control group (P=0.020). MMA mean levels were significantly higher in individuals with hyperhomocysteinemia in both groups CAD (P=0.0063) and control (P=0.013). Individuals with vitamin B12 deficiency presenting higher Hcy levels (P=0,007).Micronutrients ingestion levels did not differ significantly among the groups (P>0.05) and did not present association with Hcy, folate and MMA plasma levels (P>0.05). The obtained results have suggested that decreased expression of VEGF resultant of altered VEGF 2578A allele is a risk factor for atherosclerosis. Vitamin B12 deficiency, provided by the MMA quantification, showed to be an important risk factor either for hyperhomocysteinemia or for CAD.<br>A aterosclerose coronária resulta da interação entre fatores de risco ambientais e genéticos. Nesse sentido, o objetivo deste estudo foi investigar as freqüências de polimorfismos do gene VEGF, relacionado ao desenvolvimento de novos vasos, e dos genes MTHFR e MTR, envolvidos no metabolismo da homocisteína (Hcy), associada à formação de lesões ateroscleróticas, em 175 pacientes com doença arterial coronária (DAC) e 108 controles sem sinais angiográficos da doença. Foram analisados níveis plasmáticos de Hcy, folato e ácido metilmalônico (MMA), além da ingestão de micronutrientes requeridos para o metabolismo da Hcy. Destacaram-se como fatores de risco para a DAC hipertensão arterial (P=0,021), diabetes (P=0,029), tabagismo (P=0,006) e níveis de HDLc<40 mg/dL (P=0,0003). O genótipo alterado VEGF-2578AA foi observado em maior freqüência em pacientes com três artérias lesadas (P= P=0,008). O genótipo MTHFR 1298AA foi associado com níveis reduzidos de folato no grupo com DAC (P=0,010). Os níveis médios de MMA foram significantemente mais elevados no grupo com DAC (P=0,048). Deficiência de vitamina B12 foi prevalente no grupo com DAC (P=0,004). Foi observada uma correlação positiva entre os níveis de MMA e concentrações de Hcy no grupo com DAC (P=0,001), assim como no grupo controle (P=0,020). Os níveis médios de MMA foram significantemente mais elevados em indivíduos com hiper-homocisteinemia em ambos os grupos DAC (P=0,0063) e controle (P=0,013). Indivíduos com deficiência de B12 apresentaram níveis mais elevados de Hcy (P=0,007). Os níveis de ingestão dos micronutrientes não diferiram entre os grupos (P>0,05) e não apresentaram associação com os níveis plasmáticos de Hcy, folato e MMA (P>0,05). Os resultados obtidos sugerem que a diminuição da expressão de VEGF resultante do alelo alterado VEGF -2578A é um fator de risco para
Nota de Resumo aterosclerose. Deficiência de vitamina B12, refletida pela quantificação de MMA, se mostrou importante fator de risco tanto para hiper-homocisteinemia quanto para DAC.
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Silva, Clayton Pereira da. "Aplicação da quimiometria para caracterização química de combustíveis tipo MTR por fluorescência de raios X." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-06032013-133818/.
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No Brasil e no mundo a tecnologia nuclear vem ocupando posição de destaque com diversas aplicações na indústria, geração de energia, meio ambiente e na medicina, melhorando a qualidade de exames e tratamentos, consequentemente, a vida das pessoas. O urânio é o principal elemento utilizado em instalações nucleares, servindo como material base desde a geração de eletricidade à fabricação de radiofármacos. Nos anos 50, em meio à guerra fria, a então recém-criada Agência Internacional de Energia Atômica se propôs a supervisionar instalações nucleares e incentivar a fabricação de combustíveis nucleares com baixo teor de urânio, conhecidos como combustíveis do tipo Material Test Reactor (MTR), fabricados inicialmente na forma de U3O8 e mais tarde o U3Si2, ambos dispersos em alumínio. A utilização desta tecnologia requer uma constante melhoria de todos os processos que envolvem a fabricação do MTR sujeita a diversos protocolos internacionais, os quais procuram garantir a confiabilidade desse combustível do ponto de vista prático e ambiental. Dentro desse contexto, o controle de impurezas, do ponto de vista da economia de nêutrons, afeta diretamente a qualidade de qualquer combustível nuclear, fazendo-se necessário um controle rigoroso. A literatura reporta procedimentos que, além de gerar resíduos, são demorados e dispendiosos, pois necessitam de curva de calibração univariada e materiais de referência. Assim, o objetivo deste trabalho é estabelecer e validar uma metodologia de análise química quantitativa não destrutiva, de baixo custo e tempo de análise, tal como, minimizar a geração de resíduo para a determinação multielementar dos maiores constituintes (Utotal e Si) e as impurezas (B, Mg, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, Cd e outros) presentes em U3O8 e U3Si2, atendendo as necessidades de reatores nucleares na qualificação de combustíveis nucleares do tipo MTR. Para tanto, foi aplicada a técnica de fluorescência de raios X que permite análises químicas rápidas e não destrutivas, além de não necessitar de tratamentos químicos prévios (dissolução, digestão e outros) na fase de preparação de amostras. Para as correções de efeitos espectrais e de matriz foram aplicados e avaliados os métodos de parâmetros fundamentais, de curva de calibração univariada e de calibração multivariada. Os resultados foram comparados por meios de testes estatísticos em conformidade com a norma ISO 17025 com os MRCs (123(1-7) e 124(1-7)) de U3O8 da New Brunswick Laboratory (NBL) e 16 amostras de U3Si2 cedidas pelo CCN do IPEN-CNEN-SP. A quimiometria demonstrou-se um método promissor para a determinação de maiores e menores constituintes em combustíveis nuclear a base de U3O8 e U3Si2, uma vez que a precisão e exatidão são estatisticamente iguais aos métodos de análises volumétrica, gravimétrica e ICP-OES.<br>In Brazil and worldwide the nuclear power has occupied a prominent position with many applications in industry, power generation, environment and medicine, improving the quality of tests and treatments, therefore people\'s lives. Uranium is the main element used in nuclear facilities and its employed as base material to generation of electricity in the manufacture of radiopharmaceuticals. In the \'50s, during the Cold War, the then newly created International Atomic Energy Agency proposed to oversee nuclear facilities and encourage the manufacture of nuclear fuels with low-enriched uranium (LEU) fuel came then type Material Test Reactor (MTR), manufactured initially in U3O8 and U3Si2 later, both dispersed in aluminum. The use of this technology requires a constant improvement of all processes involving the manufacture of MTR subject to several international protocols, which seek to ensure the reliability of the fuel from the standpoint of practical and environmental. In this context, the control of impurities, from the point of view of neutron economy, directly affects the quality of any nuclear fuel, so strict control is necessary. The literature has reported procedures which, beyond generating residues, are lengthy and costly, they need calibration curve and consequently reference materials. The aim of this work is to establish and validate a methodology for nondestructive quantitative chemical analysis, low cost and analysis time, as well as minimize the generation of waste, for multielement determination of major constituents (Utotal and Si) and impurities (B, Mg, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo, Cd and others) present in U3O8 and U3Si2, meeting the needs of nuclear reactors in the nuclear fuel qualification type MTR. For that purposes, will be applied the X-ray fluorescence technique which allows fast chemical and nondestructive analysis, aside from sample preparation procedures that do not require previous chemical treatments (dissolving, digesting, and others). To corrections like effects of spectral and matrix were applied and evaluated the fundamental parameter method, univariate calibration curve and multivariate calibration. The results were compared by means of statistical tests in accordance with ISO 17025 in MRCs (123 (1-7) and 124 (1-7)) MCRs of U3O8 from New Brunswick Laboratory (NBL) and 16 U3Si2 samples provided by CC of IPEN/CNEN-SP. The chemometrics is a promising method to determination of minor and major constituents on the U3Si2 and U3O8 basis nuclear fuel, because the precision and accuracy are statistically equal volumetric analysis, gravimetric and ICP-OES methods.
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SILVA, CLAYTON P. da. "Aplicação da quimiometria para caracterização química de combustíveis tipo MTR por fluorescência de raios X." reponame:Repositório Institucional do IPEN, 2012. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10160.
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Nothin, John. "Läs instruktionen! : Reparatörers lärande och utveckling i det dagliga arbetet." Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352768.
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Yeung, Yuk-sing Wilson, and 楊昱昇. "From metro to metropolis: production and reproduction of urban spaces in Hong Kong by the MTR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B27773188.
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Yeung, Shui-ling, and 楊瑞玲. "Development impacts of rail-based transport: a case study of the proposed MTR South Island Line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B42577172.
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Neto, Ricardo Mendes Leal. "Estudo de processos de obtenção de pó de U3O8 empregado em elementos combustíveis do tipo MTR." Universidade de São Paulo, 1989. http://www.teses.usp.br/teses/disponiveis/85/85132/tde-18062012-091813/.
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Três métodos de obtenção de pó de U3O8 de alta densidade foram estudados: trituração de pastilhas sInterizadas de U3O8; sinterização de grânulos de U3O8 calcinado; e sinterização de grânulos de diuranato de amônio (DUA). Testes foram conduzidos variando-se a temperatura e o tempo de calcinação do DUA, bem como o tempo de sinterização, resultando em dez lotes de U3O8. Os processos foram comparados em termos de características dos pós obtidos, rendimento granulométríco e número de etapas. O teor de impurezas, a área de superfície específica, a estequiometria, a morfologia, a densidade, a distribuição de porosidade e a identificação de fases foram considerados como parametros de caracterização dos pós. As principais conclusões mostraram que o segundo método (no qual o DUA foi calcinado a 600°C por 3h) forneceu os melhores resultados. Além disso, o terceiro método também produziu bons resultados, porém com dificuldades de manuseio do DUA.<br>Three preparation methods of high-density U3O8 powder have been studied: grinding of sintered U3O8 pellets, sintering of calcined U3O8 granules; and sintering of ammonium diuranate (ADU) granules. Experiments have been carried out varying ADU calcination time and temperature as well as sintering time, yielding ten U3O8 batches. Powder characteristics, granulometric yield, and number of process steps have been taken into account for comparison purposes. Impurity content, specific surface area, stoichiometry, morphology, density, porosity distribution and phase identification have been considered as parameters for powder characterization. The main conclusions show that the second method (following a 6000C/3h ADU calcination) gives the best results. Moreover, the third method gives also good results, but there were some difficulties with ADU handling.
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LEAL, NETO RICARDO M. "Estudo de processos de obtencao de po de U3O8 empregado em elementos combustiveis do tipo MTR." reponame:Repositório Institucional do IPEN, 1989. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9924.
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Pan, Wubin. "Regulation of the susceptibility of Neisseria gonorrhoeae to antibiotics and hydrophobic compounds by the mtr system." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238975.
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Yeung, Shui-ling. "Development impacts of rail-based transport a case study of the proposed MTR South Island Line /." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B42577172.
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Bradley, Karen Nicola. "The in vitro effects of muscarinic toxins MT2, MT3, MT4 and MT7 isolated from the venom of Dendroaspis angusticeps." Thesis, University of Strathclyde, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366919.
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De, Vita Cédric. "Etude et optimisation de calorimètres en milieu inactif dédiés à la mesure de l"échauffement nucléaire dans le RJH : des phénomèmes physiques à l'étalonnage." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4326/document.
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L’instrumentation et la mesure en ligne pour les Material Testing Reactors sont en pleine expansion en France en particulier avec la construction du Réacteur Jules Horowitz (RJH) qui possédera des capacités expérimentales accrues (conditions extrêmes). Conception/développement/optimisation de moyens expérimentaux sont requis pour une caractérisation fine des conditions expérimentales régnant dans ce MTR. C’est dans ce contexte que s’inscrivent mes travaux de thèse. Plus précisément depuis 2009, le CEA et l'Université d'Aix-Marseille (Laboratoire IM2NP UMR7334, eq. Microcapteurs-Instrumentation) conduisent des programmes de recherche au sein du laboratoire commun LIMMEX afin de proposer de nouveaux capteurs et dispositifs dédiés à la détermination spatiale et temporelle des flux neutrons/photons et de l’échauffement nucléaire dans les matériaux inertes par interactions rayonnements nucléaires/matière dans les canaux du RJH. Les travaux de ma thèse ont porté sur la calorimétrie, méthode permettant la quantification de l’échauffement nucléaire. L’objectif était d’étudier et d’optimiser la méthode et les capteurs hors flux nucléaires et d'améliorer les étapes conduisant à la quantification de l’échauffement nucléaire. Ces travaux expérimentaux et numériques ont comporté trois volets principaux. Le 1er a porté sur des études sur la réponse et le comportement de calorimètres différentiels classiques. Le 2ème volet a été dédié à des études sur la méthode d’étalonnage des calorimètres prototypes. Le 3ème volet a consisté à l’interprétation de mesures d’échauffement nucléaire et à la simulation de nouveaux capteurs pouvant mesurer un échauffement nucléaire de 20W.g-1 dans le RJH<br>The instrumentation and on-line measurement for Material Testing Reactors are booming in France in particular with the construction of the Jules Horowitz Reactor (RJH), which possess increased experimental capacity (extreme conditions). Design / development / optimization of experimental resources are required for a detailed characterization of experimental conditions in the MTR. It is in this context that fit my thesis work. Specifically since 2009, the CEA and the University of Aix-Marseille (IM2NP Laboratory UMR7334, eq. Microcapteurs-Instrumentation) lead research programs in the LIMMEX joint laboratory to provide new sensors and devices dedicated to determining spatial and temporal neutron / photon fluxes and nuclear heating in the inert materials by nuclear radiation / matter interactions in the channels of RJH. The work of my thesis focused on calorimetry method for the quantification of nuclear heating. The objective was to study and optimize the method and sensors excluding nuclear flow and improve the steps leading to the quantification of nuclear heating. These experimental and numerical works involved three main components. The first focused on studies of the response and behavior of conventional differential calorimeters. The second part was devoted to studies on the calibration method calorimeters prototypes. The third component was the interpretation of nuclear heating measures and simulation of new sensors that can measure a nuclear heating of 20W.g-1 in the JHR
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Lukas, Carsten. "Einfluss von hochdosierten intravenösen Kortikosteroiden auf das Magnetisierungstransfer Ratio (MTR) bei Patienten mit Multipler Sklerose im akuten Schub." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967920353.
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Abdi, Sade, and Noureddine Rathmaya. "Managing employees and promoting internal communication during change : A case study of change management at MTR Tunnelbanan AB." Thesis, Mälardalens högskola, Akademin för ekonomi, samhälle och teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-37216.
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Al, Hasan Mohammad Sami. "Role of non-signage elements in the image of underground stations: a study of Hong Kong MTR users' cognitiveimage." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B42931514.
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Lu, Peng. "Effets cellulaires et moléculaires de l’invalidation conditionnelle du gène MTR au niveau du foie et du cerveau de souris." Thesis, Université de Lorraine, 2016. http://www.theses.fr/2016LORR0333/document.
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L’enzyme méthionine synthase (MTR) catalyse la reméthylation de l’homocystéine en méthionine, le précurseur du donneur universel de groupe méthyle S-Adenosylmethionine (SAM), impliqué dans des mécanismes de régulations épigénétiques. Des polymorphismes de MTR sont associés à des défauts métaboliques et des défauts de développement embryonnaire. Afin d’étudier les conséquences d’une déficience en MTR, nous avons généré des modèles murins d’invalidation conditionnelle du gène MTR de manière constitutive ou inductible dans le foie et dans le cerveau. L’invalidation constitutive ou inductible ciblée dans le foie pendant l’embryogenèse n’est pas viable, suggérant un rôle limitant de la méthionine synthase sur le développement précoce et l’organogenèse en lien probable avec les conséquences sur la prolifération cellulaire. Dans les périodes post-natales, nous avons utilisé le modèle inductible complété par une hépatectomie pour étudier les altérations de la régénération hépatique liée aux effets sur le stress cellulaire ainsi que l’expression et l’activation des cyclines. Le KO dans le cerveau induit principalement une perte des fonctions de mémorisation de l’apprentissage hippocampo-dépendant. Au total, nos résultats illustrent les effets différents de l’invalidation de MTR en fonction de l’organe considéré. Le foie est un organe très plastique avec une capacité de régénération très importante. Les effets sur les étapes de l’organogénèse et sur l’inhibition de la régénération confirment l’hypothèse du rôle majeur et limitant de la méthionine synthase dans la régulation du cycle cellulaire. Le modèle d’invalidation au niveau du cerveau confirme le rôle très important de la voie de reméthylation de l’homocystéine catalysée par la méthionine synthase, rôle qui a déjà été illustré par d’autres travaux sur les rats carencés en donneur de méthyle et sur la souris transgénique KO cd320<br>The enzyme methionine synthase (MTR) catalyzes the remethylation of homocysteine to methionine, the precursor of the methyl donor S-universal Adenosylmethionine (SAM), involved in epigenetic regulation mechanisms. We generated mouse models with conditional invalidation of the mtr gene in a constitutive or inducible manner to delete the gene expression specifically in the liver and brain. Constitutive invalidation during embryonic life is not sustainable when targeted to the liver, suggesting a limiting role of methionine synthase in early organogenesis and probably on cell proliferation. We performed hepatectomy to study regeneration-related effects on the cellular stress and found dramatic effects on cell proliferation through altered expression and activation of cyclins. The constitutive model in brain highlighted the behavioral anomalies related to a loss of learning and memory. This suggested major effects in the hippocampus. Overall, our findings highlighted the specific effects of the invalidation of methionine synthase in both organs. The liver is a plastic member with a very high regenerative capacity. The effects on organogenesis and inhibition of regeneration confirm the hypothesis for a major role of methionine synthase in cell cycle regulation. The invalidation model in the brain confirms the important role of the remethylation pathway catalysed by methionine synthase, a role which has been shown by other studies in rats deprived in methyl donors and in cd320 KO transgenic mice
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Gifford, Solomon Stephen. "A Roadmap for a Successful Software Development Team Assembly Model Using Roles." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/43109.
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Software development requires teams due to size, scope, and location of the project. A few software development team structures have been proposed based on tasks and job descriptions, but no team structure or model has been proposed to assemble software development teams based on individual characteristic and trait differences. This thesis presents two studies that support the argument that a new model needs to be developed for assembling software development teams. A roadmap for developing such a model is presented as the response to the inapplicability of applying current models to software development team assembly.<br>Master of Science
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Paulino, Cristiane Garcia [UNESP]. "Análise prospectiva do padrão de metilação nos genes associados a doenças cardíacas SCN5A e MTR para aplicação na genética forense." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/88029.
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paulino_cg_me_araiq_parcial.pdf: 377640 bytes, checksum: 4179fe3f31573884cda8bcaeb0a9769b (MD5)<br>Alterações súbitas ou prolongadas no meio ambiente podem ter influências deletérias na composição do código da vida, o (DNA). A epigenética é a visão moderna da nossa interação com o meio em que vivemos. De acordo com a Organização Mundial de Saúde, “morte súbita” é aquela que acontece até 24 horas desde o início da sintomatologia. A morte súbita de causa cardíaca, definida como uma morte natural inesperada em pessoas sem antecedentes cardiovasculares pré-conhecidos (com carácter fatal) revela-se, em todos os estudos efetuados até o momento, como a principal causa de morte na atividade física, podendo acometer tanto recém-nascidos como adultos. Diversos genes foram identificados em associação a SQTL (síndrome do QT longo – doenças genéticas que causam arritmias cardíacas potencialmente fatais), onde 90% dos casos estão relacionados a mutações no gene responsável pelo canal de sódio SCN5A (locus LQT3) e no gene MTR. A metilação do DNA é uma alteração epigenética que atua na regulação da expressão gênica, e pode estar relacionada com a morte súbita de origem cardíaca. Na metilação do DNA ocorre a adição de um radical metil (CH3) no carbono 5 de citosina geralmente seguida por guanina (dinucleotídeo CpG), catalisada por enzimas DNA metiltransferases (DNMTs). Metodologias relativamente simples permitem o conhecimento da existência de metilação no DNA. O tratamento do DNA genômico com bissulfito de sódio converte as citosinas (C) não metiladas em uracilas (U), mas não afeta as citosinas (C) metiladas, procedendo a seguir à amplificação por PCR específica para metilação e sequenciamento dos produtos selecionados a partir do DNA tratado com bissulfito. Este estudo teve como objetivos investigar diferenças nos padrões de metilação que pudessem estar associados ao desenvolvimento...<br>Prolonged or sudden changes in the environment may have deleterious influences on the content of the code of life, the (DNA). Epigenetics is the modern view of our interaction with the environment in which we live. According to the World Health Organization, sudden death is that which happens within 24 hours from the onset of symptoms. Sudden death from cardiac causes, defined as an unexpected natural death in people without cardiovascular history foreknown (with fatal character) shows up in all studies performed to date, as the leading cause of death in physical activity can affect both newborns and adults. Several genes have been identified in association with LQTS (long QT syndrome - genetic diseases that cause potentially fatal cardiac arrhythmias), where 90% of cases are related to mutations in the gene responsible for the sodium channel SCN5A (LQT3 locus) and the MTR gene. DNA methylation is an epigenetic modification that acts in the regulation of gene expression, and may be related to sudden cardiac death. DNA methylation occurs on the addition of a methyl group (CH3) carbon-5 of cytosine generally followed by guanine (CpG dinucleotide), enzyme catalyzed DNA methyltransferases (DNMTs). Methodologies allow relatively simple knowledge of the existence of DNA methylation. The treatment of genomic DNA with sodium bisulfite converts cytosine (C) at uracilas unmethylated (U), but does not affect cytosines (C) methylated by making Following amplification by methylation specific PCR and sequencing of the products selected from DNA treated with bisulfite. This study aimed to investigate differences in methylation patterns that could be associated with the development and / or recurrence of cardiovascular diseases. Therefore we assessed the pattern of methylation in the promoter region of genes... (Complete abstract click electronic access below)
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MARCONDES, GILBERTO H. "Obtencao do Usub(3)O(sub)8 para combustiveis tipo MTR a partir do tricarbonato de amonio e uranilo (TCAU)." reponame:Repositório Institucional do IPEN, 1999. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10740.
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06636.pdf: 4715244 bytes, checksum: 8df295514eae9493e07c3d6352c4bf32 (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
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Paulino, Cristiane Garcia. "Análise prospectiva do padrão de metilação nos genes associados a doenças cardíacas SCN5A e MTR para aplicação na genética forense /." Araraquara, 2013. http://hdl.handle.net/11449/88029.
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Orientador: Regina Maria Barretto Cicareli<br>Banca: Raquel Mantuaneli Scarel Caminaga<br>Banca: Maurício Bacci Junior<br>Resumo: Alterações súbitas ou prolongadas no meio ambiente podem ter influências deletérias na composição do código da vida, o (DNA). A epigenética é a visão moderna da nossa interação com o meio em que vivemos. De acordo com a Organização Mundial de Saúde, "morte súbita" é aquela que acontece até 24 horas desde o início da sintomatologia. A morte súbita de causa cardíaca, definida como uma morte natural inesperada em pessoas sem antecedentes cardiovasculares pré-conhecidos (com carácter fatal) revela-se, em todos os estudos efetuados até o momento, como a principal causa de morte na atividade física, podendo acometer tanto recém-nascidos como adultos. Diversos genes foram identificados em associação a SQTL (síndrome do QT longo - doenças genéticas que causam arritmias cardíacas potencialmente fatais), onde 90% dos casos estão relacionados a mutações no gene responsável pelo canal de sódio SCN5A (locus LQT3) e no gene MTR. A metilação do DNA é uma alteração epigenética que atua na regulação da expressão gênica, e pode estar relacionada com a morte súbita de origem cardíaca. Na metilação do DNA ocorre a adição de um radical metil (CH3) no carbono 5 de citosina geralmente seguida por guanina (dinucleotídeo CpG), catalisada por enzimas DNA metiltransferases (DNMTs). Metodologias relativamente simples permitem o conhecimento da existência de metilação no DNA. O tratamento do DNA genômico com bissulfito de sódio converte as citosinas (C) não metiladas em uracilas (U), mas não afeta as citosinas (C) metiladas, procedendo a seguir à amplificação por PCR específica para metilação e sequenciamento dos produtos selecionados a partir do DNA tratado com bissulfito. Este estudo teve como objetivos investigar diferenças nos padrões de metilação que pudessem estar associados ao desenvolvimento... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Prolonged or sudden changes in the environment may have deleterious influences on the content of the code of life, the (DNA). Epigenetics is the modern view of our interaction with the environment in which we live. According to the World Health Organization, "sudden death" is that which happens within 24 hours from the onset of symptoms. Sudden death from cardiac causes, defined as an unexpected natural death in people without cardiovascular history foreknown (with fatal character) shows up in all studies performed to date, as the leading cause of death in physical activity can affect both newborns and adults. Several genes have been identified in association with LQTS (long QT syndrome - genetic diseases that cause potentially fatal cardiac arrhythmias), where 90% of cases are related to mutations in the gene responsible for the sodium channel SCN5A (LQT3 locus) and the MTR gene. DNA methylation is an epigenetic modification that acts in the regulation of gene expression, and may be related to sudden cardiac death. DNA methylation occurs on the addition of a methyl group (CH3) carbon-5 of cytosine generally followed by guanine (CpG dinucleotide), enzyme catalyzed DNA methyltransferases (DNMTs). Methodologies allow relatively simple knowledge of the existence of DNA methylation. The treatment of genomic DNA with sodium bisulfite converts cytosine (C) at uracilas unmethylated (U), but does not affect cytosines (C) methylated by making Following amplification by methylation specific PCR and sequencing of the products selected from DNA treated with bisulfite. This study aimed to investigate differences in methylation patterns that could be associated with the development and / or recurrence of cardiovascular diseases. Therefore we assessed the pattern of methylation in the promoter region of genes... (Complete abstract click electronic access below)<br>Mestre
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Viegas, Christina. "Synthèse et évaluation biologique de nouveaux inhibiteurs de la 5-méthylthioribose kinase (MTR). : Recherche de nouveaux agents antibiotiques et antiprotozaires." Reims, 2001. http://www.theses.fr/2001REIMS023.
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La méthionine joue un rôle essentiel dans une grande variété de fonctions cellulaires : la biosynthèse des protéines, les réactions de transméthylation et la biosynthèse des polyamines. La forte demande en méthionine pour satisfaire ces fonctions essentielles ne peut être assurée par la seule synthèse de novo. Ainsi tous les processus de récupération de cet acide aminé sont d'une extrème importance pour la croissance des cellules. Chez P. Falciparum (agent responsable de la malria) et K. Pneumoniae (entérobactérie impliquée dans les infections nosocomicales pulmonaires) le recyclage de la méthionine met en jeu une voie métabolique spécifique, différente de celle des mammifères, dans laquelle la MTR kinase occupe une position clé. De ce fait, cette enzyme peut être considérée comme une cible spécifique pour la recherche de nouveaux antiprtozoaires et antibactériens. Le travail présenté dans cette thèse concerne la synthèse et évaluation biologique de nouveaux inhibiteurs de la MTR kinase. Dans une première partie de cette étude , nous avons synthétisé : - des analogues du MTR (inhibiteurs compétitifs), - des analogues bisubstrats, nucléosides et nucléotides qui combinent les déterminants structuraux du MTR et de l'ATP, - des pro-inhibiteurs de l'enzyme via leur interaction avec la MTA nucléosidase, enzyme qui précède la MTR kinase dans le cycle de régénération de la méthionine.
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Al, Hasan Mohammad Sami. "Role of non-signage elements in the image of underground stations a study of Hong Kong MTR users' cognitive image /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42931514.
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