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Journal articles on the topic 'MTT (3-(4'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Suwito, Hery, Helda Hardiyanti, Kautsar Ul Haq, Alfinda Kristanti, and Miratul Khasanah. "(E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one." Molbank 2018, no. 4 (2018): M1027. http://dx.doi.org/10.3390/m1027.

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A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, 1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltet

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2

Subramanian, Gomathy, Farhath Sherin, Naina Merin Joy, Ashish D Wadhwan, Gowramma Byran, and A. Shanish Antony. "DOCKING STUDIES AND SYNTHESIS OF NOVEL 4- THIAZOLIDINONE DERIVATIVES BEARING 1, 3, 4- OXADIAZOLE MOIETY AS SIRT-3 ACTIVATORS TARGETING PARKINSON’S DISEASE." Rasayan Journal of Chemistry 15, no. 01 (2022): 483–96. http://dx.doi.org/10.31788/rjc.2022.1516628.

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Seven protein families known as class III histone deacetylase for their characteristic features have been reported in mammals. Sirtuin3 (SIRT3) has gained considerable attention among the sirtuin members for its role in neurodegenerative disease. A new series of 4-thiazolidinones fused 1, 3, 4-oxadiazole derivatives have been designed in silico by using Schrodinger software. Molecules showing high affinity with the target protein (4JSR) were selected for the synthesis and analytical methods were used to determine the structures. The synthesized compounds III (a-h) were taken for in vitro cytot

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3

Marvaniya, Vanita, Hirak V. Joshi, Ujashkumar A. Shah, and Jayvadan K. Patel. "Docking, Synthesis and Anticancer Activity of 4-(4-(3-(4-Chloro-3-(trifluoromethyl)- phenyl)ureido)phenoxy)-N-(2-morpholinoethyl)picolinamide Derivatives." Asian Journal of Chemistry 34, no. 6 (2022): 1457–64. http://dx.doi.org/10.14233/ajchem.2022.23772.

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A new series of diaryl urea derivatives bearing pyridine moiety were designed, synthesized and evaluated for their biological activity. In this study, we applied the structure-based virtual screening (SBVS) on the high similar sorafenib approved drug, selected from the DrugBank database as well as on a series of derivatives, selected from the literature. Aim was to provide new potent anticancer agents. Analysis was performed using AutoDock VINA tools. Based on the ligand binding energy. Compounds will be synthesized by chlorination of pyridine acid derivative which further coupled with amine a

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4

Jenisha, J., J. Jebalenet, J. Brindha, and T. F. Abbs Fen Reji. "SYNTHESIS, SPECTRAL CHARACTERIZATION, DFT AND DOCKING STUDIES OF 5-(4-CHLOROPHENYL)-3-(COUMARIN-3-YL)-1H-PYRAZOLE AND 5-(4-CHLOROPHENYL)-3-(COUMARIN-3-YL)ISOXAZOLE." Журнал структурной химии 64, no. 9 (2023): 115488. http://dx.doi.org/10.26902/jsc_id115488.

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Five membered hetrocyclic moieties have been proven to possess strong biological activities. The compounds5-(4-chlorophenyl)-3-(coumarin-3-yl)-1H-pyrazoleand 5-(4-chlorophenyl)-3-(coumarin-3-yl)isoxazole were synthesized and characterized by IR,1H and 13C NMR, and high-resolution mass spectrometry.The structural optimization and the interpretation of theoretical vibrational spectra is made by the Gaussian 09 software and the B3LYP/6-31G density functional theory (DFT) approach. Bond lengths, bond angles have all been studied. The Mulliken population analysis on atomic charges is performed. The

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5

Gavazov, Kiril Blazhev, and Galya K. Toncheva. "Extraction-Spectrophotometric Studies on the Ion-Pairing Between Some 2,3,5-Substituted Monotetrazolium Cations and Anions Deriving from 4-(2-Thiazolylazo)resorcinol or 4-(2-Pyridylazo)resorcinol." JOURNAL OF ADVANCES IN CHEMISTRY 5, no. 2 (2009): 641–51. http://dx.doi.org/10.24297/jac.v5i2.2653.

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The ion-pairing between some 2,3,5-substituted monotetrazolium cations (T+) and anions deriving from 4-(2-pyridylazo)resorcinol (PAR) or 4-(2-thiazolylazo)resorcinol (TAR) was studied by water-chloroform extraction and spectrophotometry. The following tetrazolium salts (TS) were used as a source of T+: i) 2,3,5-triphenyl-2H-tetrazolium chloride (TTC); ii) 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide (MTT); iii) 3-(2-naphtyl)-2,5-diphenyl-2H-tetrazolium chloride (Tetrazolium violet, TV); and iv) 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (INT). The spe

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6

Biçer, Abdullah, and İrfan Çınar. "Investigation of the Cytotoxic Effect of 2-Amino-4-phenylthiazole Derivative Against MCF-7 and AGS Cancer Cells." Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi 30, no. 1 (2025): 61–68. https://doi.org/10.53433/yyufbed.1572502.

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This study aimed to investigate the cytotoxic effects of 2-amino thiazole compound (3) on MCF-7 breast and AGS gastric cancer cells. We examined the cytotoxic effects of various concentrations (10-25-50-100 μg/mL) of 2-aminothiazol compound (3) on MCF-7 breast cancer and AGS gastric cells at 24, 48 and 72 hours using MTT assay. MTT assays demonstrate that the 2-amino thiazole (3) compound has a time- and dose-dependent inhibitory effect on the proliferation of MCF-7 and AGS cancer cells. Analysis of the data obtained from MTT assay showed that IC50 values for thiazole were 80.13, 71.03 and 59.

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7

Anasamy, Theebaa, Ahmad Bustamam Abdul, Mohd Aspollah Sukari, et al. "A Phenylbutenoid Dimer,cis-3-(3′,4′-Dimethoxyphenyl)-4-[(E)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/939810.

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The current study was designed to evaluate thein vitrocytotoxicity effect of a phenylbutenoid dimer,cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3‴,4‴-dimethoxystyryl]cyclohex-1-ene (ZC-B11) isolated from the rhizome ofZingiber cassumunaron various cancer cell line, and normal human blood mononuclear cells, and to further investigate the involvement of apoptosis-related proteins that leads, to the probable pathway in which apoptosis is triggered. Cytotoxicity test using MTT assay showed selective inhibition of ZC-B11 towards T-acute lymphoblastic leukemia cells, CEMss, with an IC50value of7.11±0.240 μ

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8

Mshana, Robert N., Genet Tadesse, Getahun Abate, and Håkan Miörner. "Use of 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyl Tetrazolium Bromide for Rapid Detection of Rifampin-ResistantMycobacterium tuberculosis." Journal of Clinical Microbiology 36, no. 5 (1998): 1214–19. http://dx.doi.org/10.1128/jcm.36.5.1214-1219.1998.

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We describe a test which uses the ability of viable cells to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to detect resistance to a bactericidal drug, rifampin, in in vitro-cultured Mycobacterium tuberculosis. The assay shows a linear relationship between the number of viable bacteria and the ability to reduce MTT. Dead mycobacteria were unable to reduce MTT. Rifampin-sensitive M. bovis (BCG) and M. tuberculosis exposed to rifampin showed a rifampin concentration-dependent inhibition of the ability to reduce MTT, while the resistant strains were unaffected. The in

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9

Dhokale, Sandhya, Snehal Thakar, and Deepali Bansode. "Design and synthesis of novel 1-substituted -3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea and thiourea analogues targeting on TACE, as potent anticancer agents." GSC Biological and Pharmaceutical Sciences 12, no. 2 (2020): 194–205. https://doi.org/10.5281/zenodo.4268200.

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1-substituted phenyl quinazolinones analogues were designed by performing molecular modelling studies against tumour necrosis factor alpha converting enzyme (TACE PDB Id: 2A8H) and <em>in-silico </em>Lipinski properties for drug likeness.  From QSAR studies, it could be concluded that the urea and thiourea groups play a crucial role in enhancing cytotoxic effects of compounds. Substitution of halogens like trifluoromethyl, chloro and allylic functional group may enhance the cytotoxic effect of urea and thiourea analogues. Substitution of phenyl and benzoyl ring were not found ef

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10

Law, P., T. Goodwin, Q. Fang, et al. "4-33-04 Advances in clinical trials of myoblast transfer therapy (MTT)." Journal of the Neurological Sciences 150 (September 1997): S253. http://dx.doi.org/10.1016/s0022-510x(97)86116-3.

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11

Desai, S. N. Mamle, Rudrax N. S. Priolkar, Harshank A. Naik Karmali, Prabhav D. Ambe, and B. S. Biradar. "SYNTHESIS, CHARACTERIZATION AND EVALUATION OF 4-HYDROXY-1-PHENYL/METHYL-3-(3-SUBSTITUTED-1-(SUBSTITUTEDIMINO) PROPYL) QUINOLINE-2(1H)-ONE DERIVATIVES AND 4-HYDROXY-1-PHENYL/METHYL-3-(1-(SUBSTITUEDIMINO) ETHYL) QUINOLINE-2(1H)-ONE DERIVATIVES AS POSSIBLE ANTICANCER AGENTS." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 240. http://dx.doi.org/10.22159/ijpps.2017v9i10.20184.

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Objective: Synthesis, characterization and evaluation of quinolin-2-one derivatives as possible anticancer agents.Methods: A series of novel 4-hydroxy-1-phenyl/methyl-3-(3-substituted-1-(substitutedimino)propyl)quinolin-2(1H)-one derivatives IIa(1-5)/IIb(1-5) and 4-hydroxy-1-phenyl/methyl-3-(1-(substituedimino)ethyl)quinolin-2(1H)-one derivatives IIIa(1-3)/IIIb(1-3) were synthesised by nucleophilic addition of substituted anilines on 3-acetyl-4-hydroxy-1-phenyl/methylquinolin-2(1H)-one (a/b) and 4-hydroxy-3-(3-substitutedpropanoyl)-1-phenyl/methyl quinolin-2(1H)-one (Ia/Ib); respectively. The

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12

Kumar, Praveen, Jai Prakash Kumar, Juhi Barnwal, and Ritu Singh. "Design, Synthesis and Molecular Docking Studies of 4-{3-[2-(2-Morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol-1-yl}-benzenesulfonamide as Anti-Breast Cancer Agent." Asian Journal of Organic & Medicinal Chemistry 5, no. 4 (2020): 301–6. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p271.

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Novel 4-{3-[2-(2-morpholin-4-yl-ethoxy)phenyl]-5-phenyl-pyrazol- 1-yl}benzenesulfonamide (7) was synthesized and evaluated for its anti-breast cancer activity. It was prepared by cyclocondensation reaction of morpholine-substituted β-diketone, 1-[2-(2-morpholin-4-yl-ethoxy)- phenyl]-3-phenyl-propane-1,3-dione (3) with 4-hydrazinobenzenesulfonamide hydrochloride (6). Chemical structure of titled compound (7) was confirmed by FTIR, 1H & 13C NMR and HRMS spectroscoic analyses. The anticancer activity of titled compound 7 was evaluated against MCF-7 breast cancer cell line by MTT assay. Molecu

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13

Dr., G. Nagalakshmi*. "Synthesis, Characterization and Anti-HIV Evaluation of Some Novel 2-(substitutedphenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-ones." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 1352–63. https://doi.org/10.5281/zenodo.14382288.

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A series of novel 2-(substituted phenyl)-5-methyl-3-(pyridin-4-yl)-1,3-thiazolidin-4-ones (<strong>4a-g</strong>) were synthesized, structurally confirmed by elemental analysis, IR, <sup>1</sup>H NMR and MS spectral analysis, further evaluated for their anti-HIV activity and cytotoxicity in MT-4 cells infected with wild-type HIV-1 strain III<sub>B</sub> and HIV-2 strain ROD in comparison with nevirapine (NVP), azidothymidine (AZT), dideoxycytidine (DDC) and dideoxyinosine (DDI), which were used as reference drugs. The experimental results indicated that none of the synthesized compounds inhibi

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14

Mahdavi, M., A. Asadipour, S. Rajabalian, et al. "Synthesis andIn VitroCytotoxic Activity of 2-Amino-7-(dimethylamino)-4-[(trifluoromethyl)phenyl]-4H-chromenes." E-Journal of Chemistry 8, no. 2 (2011): 598–602. http://dx.doi.org/10.1155/2011/929673.

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Three 2-amino-4-(trifluoromethylphenyl)-3-cyano-7-(dimethylamino) -4H-chromene derivatives were synthesized and their cytotoxic activities were determined against six human tumor cell lines using MTT assay. Condensation of 3-(dimethylamino)phenol, trifluoromethybenzaldehydes and malonitrile in ethanol containing piperidine afforded corresponding chromenes(4a-c). The structure of the synthesized compound was confirmed by1H NMR, IR and Mass spectral data. Among compounds tested, 3-trifluoromethyl analogue(3b)was the most active against all human tumor cell lines (IC50=12-45 nM).

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15

Sergazy, Shynggys, Zarina Shulgau, Aigerim Zhulikeyeva, Yerlan Ramankulov, Irina V. Palamarchuk, and Ivan V. Kulakov. "Cytoprotective Activity of Newly Synthesized 3-(Arylmethylamino)-6-Methyl-4-Phenylpyridin-2(1H)-Ones Derivatives." Molecules 27, no. 17 (2022): 5362. http://dx.doi.org/10.3390/molecules27175362.

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Currently, studies are being conducted on the possible role of the cytoprotective effect of biologically active substances in conditions of cerebral hypoxia or cardiomyopathies. At the same time, oxidative stress is considered one of the important mechanisms of cellular cytotoxicity and a target for the action of cytoprotectors. The aim of this study is to search for derivatives of 3-(arylmethylamino)-6-methyl-4-phenylpyridin-2(1H)-ones. The probability of cytoprotective action was assessed by measuring cell viability using two tests (with neutral red dye and MTT test). It was found that some

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16

Sayekti, Endah, Jumina Jumina, Dwi Siswanta, and Mustofa Mustofa. "SINTESIS DAN AKTIVITAS ANTIKANKER SENYAWA C-4-ALILOKSI-3-METOKSIFENILKALIKS[4]RESORSINARENA." Indonesian Journal of Pure and Applied Chemistry 3, no. 1 (2021): 1. http://dx.doi.org/10.26418/indonesian.v3i1.46505.

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The aims of this study was to synthesize of C-4-alyloxy-3-methoxyphenylcalix[4]resorcinarene (3). The syntheses was conducted by condensation reaction of resorcinol with 4-allyloxy-3-methoxybenzaldehyde (2) in ethanol with hydrochloric acid as a catalyst. The (2) compound was synthesized by the reaction of the 4-hydroxy-3-methoxybenzaldehyde (vanillin) (1) via allylation reaction using an allylbromide with the sodium metal as a catalyst in ethanol. A (3) compound was orange solid. m.p. of 176–177 °C (dec.). Yield (78%). FTIR (KBr, ν; cm-1): 3441 (-OH); 3086 and 3008 (Csp2-H); 2939 (Csp3-H ); 1

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17

Gaber, Ahmed, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Ibrahim M. El-Deen, and Moamen S. Refat. "Synthesis of 1-[(Aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic Acid Derivatives and Their Breast Anticancer Activity." Crystals 11, no. 5 (2021): 571. http://dx.doi.org/10.3390/cryst11050571.

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This research aimed to produce new 1-[(aryl)(3-amino-5-oxopyrazolidin-4-ylidene) methyl]-2-oxo-1,2-dihydroquinoline-3-carboxylic acid derivatives and check their anticancer effect against the breast cancer MCF-7 cell line. The 2-oxo-1,2-dihydroquinoline-3-carboxylic acid (4) compound was obtained by hydrolyzing ethyl 2-oxo-1,2-dihydroquinoline-3-carboxylate (2) with thiourea and anhydrous potassium carbonate ethanol, which was then treated with ethyl 3-substituted 2-cyanoacrylates (6) in the presence of triethylamine in diethyl formamide to give 1-[2-(ethoxy)carbonyl-2-cyano-1-arylvinyl]-2-oxo

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18

Nitin, Kumar, lal Neetika, Nemaysh Vishal, and Mehta Luthra Pratibha. "Synthesis and in vitro anticancer activity of novel 1,4-dimethyl-9-H-carbazol-3-yl) methanamine derivatives against human glioma U87 MG cell line." World Journal of Advanced Research and Reviews 19, no. 1 (2023): 1099–108. https://doi.org/10.5281/zenodo.10295738.

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Glioblastoma Multiforme (GBM) is most aggressive type of brain tumor in adults. 1,4-dimethyl carbazoles exhibits significant anticancer activities in literature. In this research article, we synthesized a series of novel 1,4-dimethyl-9-<i>H</i>-carbazol-3-yl)methanamine  and its derivatives (13-24) and evaluated their <i>in vitro</i> cytotoxicity activities against human glioma U87 MG cell line using MTT assay for 24 h phase time period. All final carbazole derivatives were well confirmed by NMR and HRMS spectroscopy techniques. In series, few compound (<strong>15-17</strong>) found excel

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19

Gavazov, Kiril, Vanya Lekova, Atanas Dimitrov, and Georgi Patronov. "The solvent extraction and spectrophotometric determination of vanadium (V) with 4-(2-thiazolylazo)resorcinol and tetrazolium salts." Open Chemistry 5, no. 1 (2007): 257–70. http://dx.doi.org/10.2478/s11532-006-0053-x.

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AbstractThe formation and extraction of ion-associate complexes between the vanadium(V)-4-(2-thiazolylazo)resorcinol (TAR) anionic chelate and the cations of some mono-and ditetrazolium salts {3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide (Thiazolyl blue, MTT), 3-(2-naphtyl)-2,5-diphenyl-2H-tetrazolium chloride (Tetrazolium violet), 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride (Iodonitrotetrazolium chloride), 3,3′-[3,3′-dimetoxy(1,1′-biphenyl)-4,4′-diyl]-bis[2,5-diphenyl-2H-tetrazolium] chloride (Tetrazolium blue chloride) and 3,3′-(3,3′-dimetoxy-4,4′-bi

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20

Khatun, Mahbuba, Farhadul Islam, Vinod Gopalan, et al. "2', 4'-dihydroxy-3, 4-methylenedioxychalcone Activate Mitochondrial Apoptosis of Ehrlich Ascites Carcinoma Cells." Current Drug Therapy 15, no. 4 (2020): 337–50. http://dx.doi.org/10.2174/1574885514666191211122437.

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Background: Development of effective cancer-chemotherapy is the most challenging field due to the toxicity of chemo-agents. Objective: As chalcone has been known to have pharmacological applications, here the aim is to synthesized three chalcone derivatives, 2',4'-dihydroxy-3,4-methylenedioxychalcone (C1), 2'-hydroxy- 2,4, 6-trimethoxychalcone (C2) and 2'-hydroxy-4-methylchalcone (C3) and investigate their anti-cancer properties against Ehrlich Ascites Carcinoma (EAC) cell. Method: Anticancer properties against EAC cells were studied by examining growth inhibition, MTT assays, tumour-bearing m

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21

Tsimberidou, Apostolia Maria, Siqing Fu, David S. Hong, et al. "Results of IMPACT 2, a randomized study evaluating molecular profiling and targeted agents in metastatic cancer at MD Anderson Cancer Center." Journal of Clinical Oncology 42, no. 16_suppl (2024): 3153. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3153.

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3153 Background: To address the limitations of exploratory studies, we conducted IMPACT2. The primary endpoint was to compare the progression-free survival (PFS) between patients treated with matched targeted therapies (MTT) selected on the basis of tumor molecular alterations and those whose treatment was not selected on the basis of alteration analysis (non-targeted therapy, NTT). Methods: Patients with metastatic cancer and targetable alterations were randomized between the 2 arms when eligibility criteria were met (Part A, 5/2014-4/2017; sponsor, Foundation Medicine). In Part B (3/2019-9/2

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22

Tumosienė, Ingrida, Kristina Kantminienė, Arnas Klevinskas, Vilma Petrikaitė, Ilona Jonuškienė, and Vytautas Mickevičius. "Antioxidant and Anticancer Activity of Novel Derivatives of 3-[(4-Methoxyphenyl)amino]propanehydrazide." Molecules 25, no. 13 (2020): 2980. http://dx.doi.org/10.3390/molecules25132980.

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Series of novel 3-[(4-methoxyphenyl)amino]propanehydrazide derivatives bearing semicarbazide, thiosemicarbazide, thiadiazole, triazolone, triazolethione, thiophenyltriazole, furan, thiophene, naphthalene, pyrrole, isoindoline-1,3-dione, oxindole, etc. moieties were synthesized and their molecular structures were confirmed by IR, 1H-, 13C-NMR spectroscopy and mass spectrometry data. The antioxidant activity of the synthesized compounds was screened by DPPH radical scavenging method. The antioxidant activity of N-(1,3-dioxoisoindolin-2-yl)-3-((4-methoxyphenyl)amino)propanamide and 3-((4-methoxyp

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Liu, Xu-Feng, Wen-Chao Guan, and Weng-Shan Ke. "Synthesis and enhanced neuroprotective activity of C60-based ebselen derivatives." Canadian Journal of Chemistry 85, no. 3 (2007): 157–63. http://dx.doi.org/10.1139/v07-010.

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A C60-based ebselen derivative 4 was synthesized through the cycloaddition of C60 with the azide (3) containing the ebselen component. It was obtained in a four-step synthesis starting from 2-(chloroseleno)benzoyl chloride and 2-(2-aminoethoxy)ethanol in 53% yield (based on consumed C60). Its structure was characterized by 1H NMR, 13C NMR, IR, UV, and FAB-MS. To verify that the C60-based ebselen derivative 4 had enhanced antioxidative and neuroprotective activity, the C60 derivative 5 and the ebselen derivative 6 were selected to treat cortical neuronal cells using the same procedures as with

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Toncheva, Galya, Kiril Gavazov, Vanya Lekova, Kirila Stojnova, and Atanas Dimitrov. "Ternary ion-association complexes between the indium(III) - 4-(2-pyridylazo)resorcinol anionic chelate and some tetrazolium cations." Open Chemistry 9, no. 6 (2011): 1143–49. http://dx.doi.org/10.2478/s11532-011-0101-z.

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AbstractComplex formation and liquid-liquid extraction were studied in systems containing indium(III), 4-(2-pyridylazo)resorcinol (PAR), tetrazolium salt (TZS), water and chloroform. Two different TZS were used: 2,3,5-triphenyl-2H-tetrazolium chloride (TTC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT). The optimum conditions for extraction of In(III) as a ternary complex, (TT+)[In(PAR)2] or (MTT+)[In(PAR)2], were found: pH, extraction time, concentration of PAR and concentration of TZS. The constants of extraction (Kex), constants of association (β), constants of

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25

Song, Xiaoyuan, Junfang Li, Yimin Wang, et al. "Synthesis and Antibacterial Activity of Ursolic Acid Derivatives." International Journal of Sciences Volume 8, no. 2019-09 (2019): 20–23. https://doi.org/10.5281/zenodo.3979977.

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To obtained natural products with remarkable antibacterial activities, three 3-amino substituted (UA) derivatives 2, 3 and 4 were designed and synthesized, and their antibacterial activity were assayed using broth microdilution method. Compared to UA, there three derivatives present higher antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) with the minimum inhibitory concentrations of 16 to 32 μg/mL. Furthermore, their cytotoxicities to human hepatoma cell (BEL-7402) were evaluated using MTT method, and the results indicated that their derivatives had no toxici

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Silva, Thays C., Felipe J. Aidar, Aristela de Freitas Zanona, et al. "The Acute Effect of Hyperoxia on Onset of Blood Lactate Accumulation (OBLA) and Performance in Female Runners during the Maximal Treadmill Test." International Journal of Environmental Research and Public Health 18, no. 9 (2021): 4546. http://dx.doi.org/10.3390/ijerph18094546.

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The objective of this study was to analyze the acute effect of hyperoxia during the maximal treadmill test (MTT) of runners. Participants included 10 female street runners who performed the MTT under two different conditions: hyperoxia (HYPX), inhaling oxygen (60% O2) every 3 min; and normoxia (NORM), without additional oxygen inhalation. Both groups performed the MTT with increases in the slope of the run every 3 min until voluntary exhaustion. The variables of lactate concentration, the onset of blood lactate accumulation (OBLA), peripheral oxygen saturation (SpO2), heart rate (HR), and Borg

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Bellili, Soumaya, Nicholas J. Coltman, Nikolas J. Hodges, and Fatma Allouche. "Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products." Heterocyclic Communications 28, no. 1 (2022): 11–17. http://dx.doi.org/10.1515/hc-2022-0001.

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Abstract This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 precursors. The action of chlorosulfonyl isocyanate (CSI) with aminopyrazolo[3,4-d]pyrimidines 2 was found to produce triazolopyrimidinones 5 . The MTT test that quantifies mitochondrial reductive function demonstrated that in both cell lines tested (PE/CA-PJ41 and HePG2 cells), the benzamide compounds 4 are moderately toxic with PE/CA-PJ41 c

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Abadleh, Mohammed M., Mustafa M. El-Abadelah, Salim S. Sabri, Hanan H. Mohammed, Malek A. Zihlif, and Wolfgang Voelter. "Synthesis and Antitumor Activity of Some N2-(Thien-3-yl)amidrazones." Zeitschrift für Naturforschung B 69, no. 7 (2014): 811–16. http://dx.doi.org/10.5560/znb.2014-4062.

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6aA set of new N2-(thien-3-yl)amidrazones (-h) incorporating N-piperazines and related congeners has been synthesized by reacting the hydrazonoyl chloride 4(derived from 3-aminothiophene- 2-carboxylate) with the appropriate sec-cyclic amine. The antitumor activity of these compounds was evaluated on breast cancer (MCF-7) and leukemic (K562) cell lines by a cell viability assay utilizing the tetrazolium dye (MTT). The amidrazone 6d encompassing the N-piperazine moiety, was the most active against MCF-7 and K562 with IC50 of 7.28 and 9:91 μM, respectively.

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Almasirad, Ali, Loghman Firoozpour, Maliheh Nejati, et al. "Design, synthesis, and biological evaluation of new series of 2-amido-1,3,4-thiadiazole derivatives as cytotoxic agents." Zeitschrift für Naturforschung B 71, no. 3 (2016): 205–10. http://dx.doi.org/10.1515/znb-2015-0138.

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AbstractA series of novel 1,3,4-thiadiazole derivatives bearing an amide moiety were designed, synthesized, and evaluated for their in vitro antitumor activities against HL-60, SKOV-3 and MOLT-4 human tumor cell lines by MTT assay. Ethyl 2-((5-(4-methoxybenzamido)-1,3,4-thiadiazol-2-yl)thio)acetate (5f) showed the best inhibitory effect against SKOV-3 cells, with an IC50 value of 19.5 μm. In addition, the acridine orange/ethidium bromide staining assay in SKOV-3 cells suggested that the cytotoxic activity of 5f occurs via apoptosis.

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Xiaoping, Liu, Yu Zhongjie, Jiang Shasha, Wang Yi, Yang Tongxi, and Wang Chunxue. "Effect of Lipopolysaccharide and 4-(Methylnitro-samino)-1- (3-pyridyl)-1-butanone on the Proliferation of Mouse Bone Marrow Stem Cells." International Journal of Sciences Volume 5, no. 2016-02 (2016): 91–102. https://doi.org/10.5281/zenodo.3349103.

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BMSCs were isolated, cultured and proliferated in vitro. The proliferation of mouse BMSCs treated with different concentrations of LPS and NNK were detected by MTT assay, the expression of NF-κB and CUGBP1 in the BMSCs were analyzed by Immunocytochemistry assay and Western Blot. MTT results shown that different concentrations of LPS and NNK could promote the proliferation of BMSCs and the promotion effect of LPS12.5μg/ml, NNK10μg/ml and LPS12.5μg/ml combined NNK 10μg/ml was much more significant than others. Immunocytochemistry and Western Blot revealed that the location and the expression lev

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CHETANA, P. R., D. R. NAVYA, VIBHA VINAYAKUMAR BHAT, B. S. SRINATHA, and MOHAN A. DHALE. "Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline." Asian Journal of Chemistry 31, no. 6 (2019): 1265–74. http://dx.doi.org/10.14233/ajchem.2019.21889.

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A series of lanthanum(III) complexes [La(4-qtpy)2(NO3)2](NO3) (1), [La(4-qtpy)3(NO3)](NO3)2 (2), [La(4-qtpy)(phen)(NO3)2](NO3) (3) and [La(4-qtpy)(phen)2(NO3)2](NO3) (4) (4-qtpy = 4′-[(4-quinoline)-2,2′;6′,2′′-terpyridine]) were synthesized and characterized. The cyclic voltammetric studies revealed that the complexes 1 and 3 are redox active. UV-visible absorption spectral studies and viscosity measurements revealed that complexes bind to DNA through intercalation. Complexes 1 and 3 have shown the highest binding propensity (Kb = 4.241 + 0.2 × 106 for 1 and 1.492 + 0.2 × 106 for 3). The resul

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Law, Peter K., Tena G. Goodwin, Qiuwen Fang, et al. "Feasibility, Safety, and Efficacy of Myoblast Transfer Therapy on Duchenne Muscular Dystrophy Boys." Cell Transplantation 1, no. 2-3 (1992): 235–44. http://dx.doi.org/10.1177/0963689792001002-305.

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Five billion normal myoblasts were injected into each of 21 Duchenne muscular dystrophy (DMD) boys aged 6–14 yr to assess the feasibility, safety, and efficacy of the Phase II myoblast transfer therapy (MTT). The Phase II study was designed to strengthen muscles of both lower limbs. Forty-eight intramuscular injections transferred the myoblasts into 22 major muscles at 55.6 × 106/mL in 10 min under general anesthesia. Eleven boys had received 8 million myoblasts each 1 yr ago in the Phase I MTT. In the Phase II study, eight of them had their myoblasts subcultured from reserves frozen 1 yr ago.

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Goertz, R., R. Heide, T. Bernatik, et al. "Mesenteric Transit Time Using Contrast-Enhanced Ultrasound (CEUS) Does Not Correlate with Disease Activity in Crohn’s Disease." Ultraschall in der Medizin - European Journal of Ultrasound 33, no. 02 (2011): 164–69. http://dx.doi.org/10.1055/s-0031-1282064.

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Abstract Purpose: Evaluation of mesenteric transit time (MTT) – measured by contrast-enhanced ultrasound – as a marker for inflammatory activity in Crohn’s disease. Materials and Methods: The time of maximum enhancement of the contrast agent in the superior mesenteric artery and vein was determined visually and by software analysis. The MTT was calculated as the difference between these two time points. Findings were correlated with the Harvey-Bradshaw Index (HBI) using the Pearson correlation coefficient (r). In addition, a healthy control group was evaluated both in the fasting state and 1,

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Imran, Mohd, Abdulaziz Khalaf Alshammari, Khattab Fahed Alfarh, et al. "In-vitro and in-silico studies based discovery of 2-aryl-N-(4-morpholinophenyl)thiazol-4-amines as promising DNA gyrase inhibitors." Advancements in Life Sciences 11, no. 4 (2024): 912. http://dx.doi.org/10.62940/als.v11i4.3514.

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Background: DNA gyrase is an important enzyme for the survival of bacteria. Many DNA gyrase inhibitors are in clinical practice. However, these inhibitors also encompass certain toxic and drug/food interactions. This warrants the development of a new template as DNA gyrase inhibitors. Therefore, this study aimed to deliver morpholine-based thiazoles (5a-5l) as safer DNA gyrase inhibitors.Methods: The 5a-5l were prepared by reacting compound 3 with various aryl thioamides. The structures of 5a-5l were ascertained by their spectral records. The 5a-5l were subjected to their antibacterial activit

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Vasuki, B., N. Mahadevan, V. Sekar, M. Vijayabaskaran, and V. Senthil. "Synthesis and cytotoxicity of Mannich Base of Benzimidazole Derivatives against Neuroblastoma Cell line." Research Journal of Chemistry and Environment 27, no. 4 (2023): 113–19. http://dx.doi.org/10.25303/2704rjce1130119.

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The present study is to synthesize a novel Mannich base of benzimidazole derivatives and to screen for cytotoxicity in a neuroblastoma cell line using the MTT assay. 2-phenyl benzimidazole, formaldehyde, adamantine 1-carboxylicacid and substituted benzylamine such as 4-methyl, 4-methoxy, 4-chloro, 2-chloro, 4-fluoro, 3-methoxy, 4-trifluoromethyl, 3,4-dichloro and 3,5 bistrifluoromethyl were used to synthesize Mannich bases of (3r, 5r, 7r)-N-Benzyl-N-((2-phenyl-1H-benzo[d]imidazol-1-yl) methyl) adamantane-1-carboxamide. The MTT cell viability assay was performed to determine the half maximal in

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Vasyl, Vdovin, and Yarmoluk Sergiy. "The cytotoxic effect of some synthetic nitrogen-containing heterocyclic compounds on cultures of tumour and normal cells and the calculation of their ADME, QSAR, and DFT pharmacological properties." ScienceRise: Biological Science, no. 1(30) (March 31, 2022): 26–37. https://doi.org/10.15587/2519-8025.2022.256113.

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The cytotoxic effect of several synthetic nitrogen-containing heterocyclic compounds on cultures of tumour and normal cells and the calculation of their ADME, QSAR, and DFT pharmacological properties <strong>The aim.</strong> The purpose of our work was to investigate the cytotoxic influence of some synthetic nitrogen-containing heterocyclic compounds, namely imidazole, aurones, and triazole on the culture of tumour cells of melanoma mouse B16, human glioma U251 and normal HEK293 and their ADME, QSAR, and DFT pharmacological properties calculation. <strong>Materials and methods.</strong>&

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Pantelić, Nebojša Đ., Bojana B. Zmejkovski, Željko Žižak, et al. "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione." Journal of Chemistry 2019 (January 17, 2019): 1–8. http://dx.doi.org/10.1155/2019/2905840.

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A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. In vitro anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines with IC50

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Jaskulska, Agata, Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Tomasz Janecki, and Anna Ewa Janecka. "Synthesis and Anticancer Properties of New 3-Methylidene-1-sulfonyl-2,3-dihydroquinolin-4(1H)-ones." Molecules 27, no. 11 (2022): 3597. http://dx.doi.org/10.3390/molecules27113597.

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Quinolinones have been known for a long time as broad-spectrum synthetic antibiotics. More recently, the anticancer potential of this group of compounds has been investigated. Following this direction, we obtained a small library of 3-methylidene-1-sulfonyl-2,3-dihydroquinolin-4(1H)-ones with various substituents at positions 1, 2, 6, and 7 of the quinolinone ring system. The cytotoxic activity of the synthesized analogs was tested in the MTT assay on two cancer cell lines in order to determine the structure–activity relationship. All compounds produced high cytotoxic effects in MCF-7, and eve

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Mueller, Henrik, Matthias U. Kassack, and Michael Wiese. "Comparison of the Usefulness of the MTT, ATP, and Calcein Assays to Predict the Potency of Cytotoxic Agents in Various Human Cancer Cell Lines." Journal of Biomolecular Screening 9, no. 6 (2004): 506–15. http://dx.doi.org/10.1177/1087057104265386.

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Cell viability assays are important tools in oncological research and clinical practice to assess the tumor cell sensitivity of individual patients. The purpose of this study was to demonstrate the comparability of 3 widely used assays (MTT, ATP, calcein assays) by principal component analysis. The study included 4 different cytostatics (cisplatin, docetaxel, doxorubicin, vinblastine) and 3 different human cancer cell lines (MCF-7, A2780, doxorubicin resistant A2780adr). Ninety-three percent of the total variance of all variables included in the principal component analysis (resulting from 3 c

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Contributors to the current issue. "General Considerations of This Issue." Scientific Journal of Cosmointel 2, no. 10 (2023): 8–13. http://dx.doi.org/10.61450/joci.v2i10.148.

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General Considerations of This Issue: 1- Introduction, 2- The research methodology in the study of T-Consciousness, 3- Research phases of Sciencefact, 4-Methods, 4.1 Taheri Consciousness Field application, 4.2 Cell culture, 4.3 MTT assay, 4.4 Cell cycle analysis, 4.5 Evaluation of apoptosis by flow cytometry, 4.6 Statistical analysis

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Van Linh, Nguyen, Hoang Le Tuan Anh, Duong Thi Hai Yen, et al. "Phenolic Components from the Aerial Parts of Agrimonia pilosa." Natural Product Communications 12, no. 7 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200720.

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Two new resorcinol derivatives, named agrimopilosides A and B (1 and 2), along with two known compounds, (2 S, 3 S)-aromadendrin 3-O-β-D-glucopyranoside (3), (2 S, 3 S)-glucodistylin (4) were isolated from the aerial parts of Agrimonia pilosa. Their chemical structures were determined by mean of HRMS, NMR, CD spectra, and as well as by comparison with the reported data. At concentration of 20 μM, compounds 1–4 modestly inhibited NO production in LPS-stimulated RAW264.7 cells, with the inhibitory rates in the range of 9.55–33.73%. None of them showed cytotoxicity toward HepG2, MCF-7, and SK-LU-

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42

Bhate, Manjiri, Ravindra Kumar Jain, A. S. Smiline Girija, and Raghunandhakumar. "Evaluation of the Cytotoxicity and Anti-biofilm Activity Of A Novel Dentifrice Containing 4-Hydroxycinnamic Acid: An In-Vitro Study." International Journal of Orthodontic Rehabilitation 16, no. 1 (2025): 38–47. https://doi.org/10.56501/intjorthodrehabil.v16i1.1172.

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INTRODUCTION: Evaluating biocompatibility is critical for assessing the safety and therapeutic potential of compounds, often serving as a preliminary step in product development. This study aims to evaluate the biocompatibility and anti-biofilm activity of a novel dentifrice containing 4-hydroxycinnamic acid (4-HCA) against Streptococcus mutans (SM) and Lactobacillus acidophilus (LA). MATERIALS AND METHODS: The present in vitro study involved three groups- Group 1- commercially available dentifrice as control, Group 2- 0.2% 4-HCA dentifrice, Group 3- 0.4% 4-HCA dentifrice. The antibiofilm effi

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Yang, Ai Mei, Jing Sun, Hui Li, Hui Jun Yuan, and Jie Li Liu. "Chemical Constituents and Anti-Tumor Activity of Gentiana farreri." Advanced Materials Research 554-556 (July 2012): 1682–85. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.1682.

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Five triterpenoids were isolated from Gentiana farreri, which was used as traditonal Tibetan medicine in the treatment of some diseases. Their structures were identified as: pseudotaraxasterol (1), lupeol (2), ursolic acid (3), 2α, 3ß-dihydroxylursolic acid (4), 2α,3ß-dihydroxyloleanolic acid (5). All these compounds were isolated from G. farreri for the first time. The cytotoxic activity on the growth of HepG-2 cells of all compounds were investigated in MTT assay, the results showed that compound 3, 4, 5 have high cytotoxic activity, IC50 is 100.88, 13.03, 13.19 (μg/ml), respectively.

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He, Guo-Xu, and Ling-Wei Xue. "Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide." Acta Chimica Slovenica 68, no. 3 (2021): 567–74. http://dx.doi.org/10.17344/acsi.2020.6333.

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A series of three new hydrazone compounds derived from the condensation reactions of 4-dimethylaminobenzohydrazide with 4-dimethylaminobenzaldehyde, 2-chloro-5-nitrobenzaldehyde and 3-methoxybenzaldehyde, respectively, were prepared. The compounds were characterized by elemental analysis, infrared and UV-vis spectra, HRMS, 1H NMR and 13C NMR spectra, and single crystal X-ray diffraction. Crystals of the compounds are stabilized by hydrogen bonds. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal

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Lukovic, Jovan, Marina Mitrovic, Ivanka Zelen, Petar Čanovic, Milan Zaric, and Ivana Nikolic. "Antitumor Effect of the Chalcone Analogue, (E) -1-(4-Ethoxy-3-Methoxyphenyl) -5- Methylhex-1-En-3-One on HeLa Cell Line." Serbian Journal of Experimental and Clinical Research 20, no. 3 (2019): 215–21. http://dx.doi.org/10.2478/sjecr-2018-0048.

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Abstract Chalcones represent precursor compounds for flavonoids biosynthesis in plants. Chalcones, 1,3-diaryl-2-propen-1-ones, have unique chemical structure with conjugated double bonds and delocalized π-electron system on both aromatic rings. Various studies have shown that chemical structure of chalcone is responsible for their antitumor effect. In our study, we have examined the antitumor effect of chalcone analogue (E) -1- (4-ethoxy-3-methoxyphenyl) -5-methylhex-1-en-3-one (CH) on HeLa cells. The antitumor efficiency of different CH concentrations was compared to the antitumor effects of

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46

Pantelić, Nebojša, Bojana B. Zmejkovski, Željko Žižak, et al. "Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione." Journal Chemistry 2019, Article ID 2905840 (2019): 8 pages. https://doi.org/10.1155/2019/2905840.

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A novel triphenyltin(IV) compound with 1-(4-carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione was synthesized and characterized by IR, NMR spectroscopy, mass spectrometry, and elemental analysis. <em>In vitro</em> anticancer activity of ligand precursor and synthesized organotin(IV) compound was determined against tumor cell lines: human adenocarcinoma (HeLa), human myelogenous leukemia (K562), and human breast cancer (MDA-MB-453), using microculture tetrazolium test (MTT) assay. The results indicate that complex exhibited very high antiproliferative activity against all tested cell lines w

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Rasmussen, Mads, Niels Juul, Søren M. Christensen, et al. "Cerebral Blood Flow, Blood Volume, and Mean Transit Time Responses to Propofol and Indomethacin in Peritumor and Contralateral Brain Regions." Anesthesiology 112, no. 1 (2010): 50–56. http://dx.doi.org/10.1097/aln.0b013e3181c38bd3.

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Background The regional cerebral blood flow (CBF) response to propofol and indomethacin may be abnormal in patients with brain tumors. First, the authors tested the hypothesis that during propofol anesthesia alone and combined with indomethacin, changes in CBF, cerebral blood volume (CBV), and plasma mean transit time (MTT) differ in the peritumoral tissue compared with the contralateral normal brain region. Second, the authors tested the hypothesis that CBF and CBV are reduced and MTT is prolonged, in both regions during propofol anesthesia and indomethacin administration compared with propof

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Shoeb, Mohammad, Sezgin Celik, Lutfun Nahar, et al. "Two Salonitenolide Derivatives from the Aerial Parts of Centaurea Gigantea Inhibit the Growth of Colorectal Cancer Cells in Vitro." Natural Product Communications 2, no. 2 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200202.

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The cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide (2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC50 values for 1 and 2 were found to be 8.5 and 26.4 μM, respectively.

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Xue, Jia-Yu, Zhu-Ping Xiao, Lei Shi, Shu-Hua Tan, Huan-Qiu Li, and Hai-Liang Zhu. "Synthesis and Structure - Activity Relationship Analysis of Enamines as Potential Antibacterial Agents." Australian Journal of Chemistry 60, no. 12 (2007): 957. http://dx.doi.org/10.1071/ch07235.

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Twenty-four new enamines [(Z)-4–15 and (E)-4–15] were synthesized for the first time. Their chemical structures were determined by means of 1H NMR spectroscopy, electrospray ionization-mass spectrometry, and elemental analysis. All of the compounds were assayed for antibacterial (Bacillus subtilis ATCC 6633, Escherichia coli ATCC 35218, Pseudomonas fluorescens ATCC 13525, and Staphylococcus aureus ATCC 6538) and antifungal (Aspergillus niger ATCC 16404, Candida albicans ATCC 10231, and Trichophyton rubrum ATCC 10218) activities by the 3-(4,5-dimethyl thiazole-2yl)-2,5-diphenyl tetrazolium brom

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Etnoori, Sharada, Nagendra Babu Chilakala, Raju Barothu, A. M. S. Krishna, Vishnu Thumma, and Premalatha Kokku. "Synthesis and Characterization of Quinoxaline Anchored Bis(1,2,3-triazole) Derivatives as Potent Anticancer Agents." Asian Journal of Chemistry 36, no. 11 (2024): 2683–88. http://dx.doi.org/10.14233/ajchem.2024.32710.

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The synthesis of 1,4-bis((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-1,4-dihydroquinoxaline-2,3-dione derivatives (6a-l) was accomplished through click chemistry protocol. The synthesized compounds were screened for their in vitro anticancer activity against MCF-7, PC-3 and HeLa cancer cell lines by MTT assay using doxorubicin as standard reference. Compounds 6g (4-cyano), 6l (4-bromo), 6c (4-chloro) and 6i (4-methyl) demonstrated promising percentage growth inhibition against all the three cell lines in comparison to doxorubicin. The determined IC50 value proved their efficacy against all cell li

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