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Rivas, Ramón D. "Museo Universitario de Antropología, MUA." Revista de Museología "Kóot", no. 3 (July 14, 2013): 117–20. http://dx.doi.org/10.5377/koot.v0i3.1168.
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Shaka, Angeline. "Hula for the Future: Patrick Makuakāne and the Hula Mua “Salva Mea”." Theatre Journal 67, no. 3 (2015): 487–501. http://dx.doi.org/10.1353/tj.2015.0086.
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Knapp, Paul, Luke Weishuhn, Natalie Pizzimenti, and David C. Markel. "Risk factors for manipulation under anaesthesia after total knee arthroplasty." Bone & Joint Journal 102-B, no. 6_Supple_A (June 2020): 66–72. http://dx.doi.org/10.1302/0301-620x.102b6.bjj-2019-1580.r1.
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Aims Postoperative range of movement (ROM) is an important measure of successful and satisfying total knee arthroplasty (TKA). Reduced postoperative ROM may be evident in up to 20% of all TKAs and negatively affects satisfaction. To improve ROM, manipulation under anaesthesia (MUA) may be performed. Historically, a limited ROM preoperatively was used as the key harbinger of the postoperative ROM. However, comorbidities may also be useful in predicting postoperative stiffness. The goal was to assess preoperative comorbidities in patients undergoing TKA relative to incidence of postoperative MUA. The hope is to forecast those who may be at increased risk and determine if MUA is an effective form of treatment. Methods Prospectively collected data of TKAs performed at our institution’s two hospitals from August 2014 to August 2018 were evaluated for incidence of MUA. Comorbid conditions, risk factors, implant component design and fixation method (cemented vs cementless), and discharge disposition were analyzed. Overall, 3,556 TKAs met the inclusion criteria. Of those, 164 underwent MUA. Results Patients with increased age and body mass index (BMI) had decreased likelihood of MUA. For every one-year increase in age, the likelihood of MUA decreased by 4%. Similarly, for every one-unit increase in BMI the likelihood of MUA decreased by 6%. There were no differences in incidence of MUA between component type/design or fixation method. Current or former smokers were more likely to have no MUA. Surprisingly, patients discharged to home health service or skilled nursing facility were approximately 40% and 70% less likely than those discharged home with outpatient therapy to be in the MUA group. MUA was effective, with a mean increased ROM of 32.81° (SD 19.85°; -15° to 90°). Conclusion Younger, thinner patients had highest incidence of MUA. Effect of discharge disposition on rate of MUA was an important finding and may influence surgeons’ decisions. Interestingly, use of cement and component design (constraint) did not impact incidence of MUA. Level of Evidence II: Prospective cohort study. Cite this article: Bone Joint J 2020;102-B(6 Supple A):66–72.
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Pierce, Todd, Kimona Issa, Anthony Festa, Anthony Scillia, Vincent McInerney, and Michael Mont. "Does Manipulation under Anesthesia Increase the Risk of Revision Total Knee Arthroplasty? A Matched Case Control Study." Journal of Knee Surgery 30, no. 07 (February 14, 2017): 730–33. http://dx.doi.org/10.1055/s-0037-1598040.
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Manipulation under anesthesia (MUA) can help patients regain an adequate range of motion (ROM) following total knee arthroplasty (TKA). Although there are studies reporting that MUA can assist in improving ROM, there is a paucity of studies regarding whether requiring an MUA is associated with an increased risk of revision. The purpose of this study was to assess the: (1) incidence of revision TKA and (2) outcomes of those undergoing MUA and compare it with a matched cohort who did not require MUA. A prospectively collected database of two high-volume institutions was assessed for patients who required a single MUA following TKA between 2005 and 2011. We found a total of 138 knees with a mean 8.5-year follow-up post-MUA. We compared this with a matched cohort (1:1) who underwent TKA during this same time period but did not require an MUA. Incidence of revision surgery and clinical outcomes were compared between the two cohorts. Within the MUA cohort, nine knees underwent revision, which was similar to the matched cohort that had seven revisions (93 vs. 95%; p = 0.6). The mean KSS-functional (88 vs. 90 points; p = 0.15) and clinical scores (87 vs. 89 points; p = 0.1) were similar between the two cohorts. Undergoing an MUA was not associated with an increased risk of revision TKA. If patients require MUA, they may still achieve satisfactory outcomes. This information can be used in educating patients so they may be able to formulate their expectations following their MUA.
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Chirea, Mariana, Carlos M. Pereira, and Fernando Silva. "Hydrogen Bonding: A Bottom-Up Approach for the Synthesis of Films Composed of Gold Nanoparticles." Journal of Nano Research 2 (August 2008): 115–28. http://dx.doi.org/10.4028/www.scientific.net/jnanor.2.115.
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Citrate gold nanoparticles of 13.5 nm average diameters have been synthesized by Turkevich method and further functionalized by place exchange reaction using mercaptosuccinic acid (MSA), 1,4-benezenedimethanethiol (1,4BDMT) or mercaptoundecanoic acid (MUA) as the incoming ligands. In the first case, the functionalization of the gold clusters with MSA yielded solution of blue color and large aggregates on carbon grids. Moreover, after filtration and drying, any film formed by hydrogen bonding, could not be removed from the filter, being embedded into the filter texture. The second ligand used for the place exchange reaction, the 1,4BDMT, determined the change of the solution color from red to dark purple, and generation of a purple powder but no film formation. In the third case, the purification and drying of the MUA functionalized gold clusters yielded films of purple color with homogenous composition, robustness, soft topographies and remarkable optical properties which were dependent on their thicknesses. The Au-MUA NP films obtained are new, being generated by hydrogen bonding and having features which makes them very attractive for the fabrication of optoelectronic devices. The long alkyl chained thiol proved to be the adequate ligand for film synthesis.
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Minh, Nguyễn Thị Bình, Khúc Đình Nam, and Trần Thị Thanh Thuận. "Các nhân tố ảnh hưởng đến quyết định mua bảo hiểm nhân thọ của khách hàng cá nhân tại Tp. Hồ Chí Minh." TẠP CHÍ KHOA HỌC ĐẠI HỌC MỞ THÀNH PHỐ HỒ CHÍ MINH - KINH TẾ VÀ QUẢN TRỊ KINH DOANH 16, no. 2 (May 29, 2021): 156–69. http://dx.doi.org/10.46223/hcmcoujs.econ.vi.16.2.961.2021.
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Mục tiêu nghiên cứu này là xác định các nhân tố ảnh hưởng đến quyết định mua Bảo Hiểm Nhân Thọ (BHNT) của khách hàng cá nhân tại TP. Hồ Chí Minh. Nhóm tác giả đã thu thập dữ liệu thông qua phỏng vấn 251 khách hàng cá nhân đã mua BHNT tại địa bàn nghiên cứu. Mô hình nghiên cứu được xây dựng dựa trên sự kết hợp giữa lý thuyết về quá trình ra quyết định (Kotler & Keller, 2012) và lý thuyết về hành vi người tiêu dùng (Sheth, Mittal, & Newman, 1999). Kết quả nghiên cứu cho thấy có 05 nhân tố ảnh hưởng đến quyết định mua mua bảo hiểm nhân thọ được sắp xếp theo thứ tự mức độ giảm dần như sau: (i) Nhận thức về giá trị của BHNT, (ii) Thương hiệu công ty BHNT, (iii) Rào cản mua BHNT, (iv) Tư vấn viên BHNT và (v) Động cơ mua BHNT; trong đó chỉ có nhân tố Rào cản mua BHNT có tác động nghịch chiều với quyết định mua BHNT còn các nhân tố khác có tác động cùng chiều với quyết định mua. Sau cùng, nhóm tác giả đề xuất một số khuyến nghị nhằm gia tăng khách hàng cá nhân tham gia BHNT và hướng nghiên cứu trong tương lai.
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Mohammed, Riazuddin, Shakir Syed, and Naveed Ahmed. "Manipulation Under Anaesthesia for Stiffness Following Knee Arthroplasty." Annals of The Royal College of Surgeons of England 91, no. 3 (April 2009): 220–23. http://dx.doi.org/10.1308/003588409x359321.
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INTRODUCTION Stiffness following knee arthroplasty is a frustrating complication and a significantly disabling problem. We present our experience of knee stiffness requiring manipulation under anaesthesia (MUA) as the first line of treatment following partial or total knee arthroplasty. PATIENTS AND METHODS All stiff knees requiring MUA over a 6-month period from March to August 2007 were retrospectively analysed from theatre records and case notes. Data were collected regarding demographics, range of knee motion before and after manipulation and at subsequent follow-up. Complications of the procedure and outcomes were also analysed. RESULTS Twenty-one patients (11 female, 10 male) underwent MUA. The average age was 62 years (range, 56–80 years). Sixteen primary and 3 revision total knee replacements underwent manipulation, as did one medial unicompartmental replacement and one patellofemoral arthroplasty. General anaesthesia with good muscle relaxation was used in all but one patient. The mean duration between arthroplasty and MUA was 13.2 weeks (range, 6-32 weeks). The range of knee movement improved from a mean range of 10.4–71.2° in the pre-MUA period to 2.1–94.0° post-MUA and at follow-up was 2.3–91.9°. The mean arc of motion improved from 60.2° (range, 40–80°) pre-MUA to 91.9° (range, 45–120°) post-MUA. The mean improvement in the arc of motion was 31.6° (P < 0.001). At an average follow-up of 3 months (range, 6 weeks to 8 months), the mean arc of motion was 90.4° (range, 40–120°). The mean improvement in knee movement from the pre-MUA at the follow-up was 30.2° (P < 0.001). One patient failed to gain any improvement from MUA. There were no complications noted from the procedure. CONCLUSIONS MUA has a role in the treatment of early stiffness with excellent immediate outcomes. We advocate that MUA should be the first line of management for stiff knee arthroplasties after failed physiotherapy.
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Nguyên, Ðình-Hoà, and Nguyên Thi Ngọc-Dung. "Sài gòn Năng Nhó Mua Thuong." World Literature Today 71, no. 4 (1997): 879. http://dx.doi.org/10.2307/40153511.
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Somfongbouthtakhan, Chinda. "THE IMPACTS OF DIGITAL MARKETING ON ONLINE SHOPPING BEHAVIOR THROUGH ONLINE SHOPPING APPLICATION IN THAI NGUYEN CITY." TNU Journal of Science and Technology 226, no. 09 (June 4, 2021): 65–72. http://dx.doi.org/10.34238/tnu-jst.4379.
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Bài nghiên cứu này chỉ ra tác động của tiếp thị số lên hành vi mua sắm online thông qua các ứng dụng mua hàng online, tập trung vào ngành công nghiệp bán lẻ ở Thái Nguyên. Đặc biệt, bài viết cũng sẽ đưa ra vai trò trung gian của các ứng dụng mua sắm online trong mối quan hệ giữa tiếp thị số và hành vi mua hàng online. Thêm vào đó, nghiên cứu cũng đưa ra một số gợi ý cho các công ty bán lẻ sử dụng Internet để phát triển doanh nghiệp. Bài viết dựa trên một khảo sát online trên biểu mẫu Google, bảng hỏi thu thập dữ liệu từ 416 người tiêu dùng. Số liệu được xử lý bằng phần mềm IMB SPSS. Kết quả chỉ ra rằng có 1 mối quan hệ giữa tiếp thị số và hành vi mua sắm trực tuyến qua trung gian là các ứng dụng mua sắm, đồng thời, các ứng dụng mua sắm cũng có ảnh hưởng đáng kể lên hành vi mua hàng trực tuyến. Cuối cùng, nghiên cứu gợi ý cách làm nội dung tiếp thị hiệu quả hơn cho các trang mua sắm trực tuyến giúp quá trình mua hàng của người tiêu dùng đơn giản, thuận tiện hơn. Đồng thời, nghiên cứu này cũng cung cấp thông tin cho các doanh nghiệp bán hàng trực tuyến để ứng dụng thành công tiếp thị số như một chiến lược trong kế hoạch kinh doanh của họ, và nhận ra tầm quan trọng của tiếp thị số trong thị trường cạnh tranh ngày nay.
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Ohkura, Satoshi, Toru Ichimaru, Fumiaki Itoh, Shuichi Matsuyama, and Hiroaki Okamura. "Further Evidence for the Role of Glucose as a Metabolic Regulator of Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats." Endocrinology 145, no. 7 (July 1, 2004): 3239–46. http://dx.doi.org/10.1210/en.2003-1516.
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Abstract The present study examined the relative importance of blood glucose vs. free fatty acids as a metabolic signal regulating GnRH release as measured electrophysiologically by multiple-unit activity (MUA) in the arcuate nucleus/median eminence region in ovariectomized, estradiol-treated goats. MUA was recorded before, during, and after: 1) cellular glucoprivation by peripheral infusion of 2-deoxy-d-glucose (2DG; 25, 50, and 75 mg/kg·h, iv); 2) peripheral hypoglycemia in response to various doses (15–195 mU/kg·h, iv) of insulin infusion; and 3) cellular lipoprivation induced by peripheral infusion of sodium mercaptoacetate (MA; 2.4 mg/kg·h alone or combined with 25 mg/kg·h of 2DG, iv), and effects on the interval of characteristic increases in MUA (MUA volleys) were examined. Infusion of the highest dose of 2DG increased the mean interval between MUA volleys, whereas the lower doses of 2DG had no effect on volley interval. The MUA volley intervals lengthened as insulin-induced hypoglycemia became profound. There was a negative correlation between MUA volley intervals and blood glucose concentrations during insulin infusion, and coinfusion of glucose with insulin returned the MUA volley interval to a normal frequency. Infusion of MA alone or MA with 2DG did not increase MUA volley intervals. These findings demonstrate that glucose availability, but not fatty acids, regulates the GnRH pulse generator activity in the ruminant. Glucose is considered a key metabolic regulator that fine-tunes pulsatile GnRH release.
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Shioi, Go, Michinari Shoji, Masashi Nakamura, Takeshi Ishihara, Isao Katsura, Hajime Fujisawa, and Shin Takagi. "Mutations Affecting Nerve Attachment of Caenorhabditis elegans." Genetics 157, no. 4 (April 1, 2001): 1611–22. http://dx.doi.org/10.1093/genetics/157.4.1611.
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Abstract Using a pan-neuronal GFP marker, a morphological screen was performed to detect Caenorhabditis elegans larval lethal mutants with severely disorganized major nerve cords. We recovered and characterized 21 mutants that displayed displacement or detachment of the ventral nerve cord from the body wall (Ven: ventral cord abnormal). Six mutations defined three novel genetic loci: ven-1, ven-2, and ven-3. Fifteen mutations proved to be alleles of previously identified muscle attachment/positioning genes, mup-4, mua-1, mua-5, and mua-6. All the mutants also displayed muscle attachment/positioning defects characteristic of mua/mup mutants. The pan-neuronal GFP marker also revealed that mutants of other mua/mup loci, such as mup-1, mup-2, and mua-2, exhibited the Ven defect. The hypodermis, the excretory canal, and the gonad were morphologically abnormal in some of the mutants. The pleiotropic nature of the defects indicates that ven and mua/mup genes are required generally for the maintenance of attachment of tissues to the body wall in C. elegans.
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Li, Zheng, Fei Lan, Yanyan Shen, Shuai An, Na Xu, Cheng Yin, Wei Yu, Weiguang Ye, Guanglei Cao, and Tianlong Wang. "Prediction of the need for manipulation under anesthesia for flexion contracture after total knee arthroplasty in patients of advanced age." Journal of International Medical Research 47, no. 7 (May 30, 2019): 3061–69. http://dx.doi.org/10.1177/0300060519851328.
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Objective This study was performed to develop a prediction model for requiring manipulation under anesthesia (MUA) for flexion contracture after total knee arthroplasty (TKA) in patients of advanced age. Methods We retrospectively reviewed 269 patients of advanced age undergoing primary TKA in one center with a minimum 1-year follow-up. Patients who underwent postoperative MUA had flexion contracture of >10° after 4 weeks of postoperative rehabilitation, and their demographic data and preoperative clinical conditions [knee diagnosis, diabetes mellitus, hypertension, lumbar spinal disorders, hip disorders, ankle disorders, knee deformity (varus/valgus), preoperative flexion contracture (PFC), range of motion (ROM), and Hospital for Special Surgery (HSS) knee score] were compared with those of patients without MUA. All preoperative factors were collected to develop the predictive model. Results Thirty patients underwent MUA. Patients who underwent MUA after surgery had significant differences in PFC, higher HSS knee scores before surgery (59.10 ± 7.22 vs. 55.70 ± 13.09), and lower preoperative ROM (81.57 ± 30.86 vs. 95.47 ± 24.36) than those who did not undergo MUA. Conclusion A prediction model for MUA in advanced-age patients with flexion contracture was developed and mainly consisted of preoperative risk factors including PFC, HSS scores, and ROM.
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Cancienne, Jourdan M., James E. Christensen, David R. Diduch, Stephen F. Brockmeier, and Brian C. Werner. "Biceps Tenodesis versus Tenotomy at the Time of Manipulation and Lysis of Adhesions for Adhesive Capsulitis." Orthopaedic Journal of Sports Medicine 7, no. 7_suppl5 (July 2019): 2325967119S0038. http://dx.doi.org/10.1177/2325967119s00389.
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Objectives: Although rare in the treatment of adhesive capsulitis, arthroscopic lysis of adhesions and manipulation under anesthesia (LOA/MUA) may be necessary if the patient fails conservative therapy. Patients at the time of surgery often have biceps tendon, superior labrum anterior to posterior (SLAP) pathology, or other pathology requiring concurrent treatment. Common treatments for these can include biceps tenodesis or tenotomy. Some surgeons believe that concomitant repairs at the time of LOA/MUA can cause increased stiffness post-operatively due to need for immobilization or protection, possibly leading to poorer outcomes and potentially needing further interventions such as repeat injections or repeat LOA/MUA. The goal of this study was to compare patients who underwent LOA/MUA with biceps tenodesis to those who underwent LOA/MUA with biceps tenotomy. We hypothesized that biceps tenodesis at the time of LOA/MUA did not lead to an increased risk for further intervention in the form of post-operative injections for pain or stiffness or repeat LOA/MUA compared to biceps tenotomy. Methods: A retrospective review of consecutive LOA/MUA for adhesive capsulitis performed by 5 surgeons at a single center from 2010-2016 was performed. All included patients were required to have a minimum of 1 year of follow-up, and be a minimum 2 years post-procedure. Exclusion criteria included prior biceps tenodesis, surgery within six months prior to LOA/MUA, prior infection, prior shoulder fracture or fracture fixation, and concomitant rotator cuff repair. Patients without any biceps surgery (tenotomy or tenodesis) were also excluded. The primary outcome measure was a postoperative injection in the ipsilateral shoulder for recurrent adhesive capsulitis, pain or residual stiffness. The secondary outcome measure was a repeat LOA/MUA. Statistical analysis was completed in SPSS using a chi-square analysis for categorical variables and a student’s t-test for continuous variables. Results: Fifty-five patients were included in the study. Thirty-three patients underwent biceps tenotomy, and 22 patients underwent biceps tenodesis at the time of arthroscopic LOA/MUA. The average age in the tenotomy group was 53 years and 47 years in the tenodesis group (p = 0.383). There was no significant difference in the percentage of males in the tenodesis group (59%) versus tenotomy (48%) (p = 0.440). Average body mass index (BMI) was not significantly different between the two groups (p = 0.329). No patients from either group underwent repeat LOA/MUA. Of those patients who received a biceps tenotomy, 39% had an injection for pain or stiffness post-operatively compared to 18% for biceps tenodesis, which was not significant (p=0.17). Table 1 summarizes the outcomes in both groups. Conclusion: Patients who underwent biceps tenodesis with concurrent arthroscopic LOA/MUA for adhesive capsulitis did not have a higher rate of postoperative injections or repeat LOA/MUA compared to patients who underwent biceps tenotomy at the time of LOA/MUA. [Table: see text]
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Minarni, Ani. "On Eight Grade Students Understanding in Solving Mathematical Problems." Asian Social Science 13, no. 12 (November 28, 2017): 86. http://dx.doi.org/10.5539/ass.v13n12p86.
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Human must have the ability to understand, because understanding can prevent people from misunderstandings and conflicts. Similarly, public junior high school (PJHS) students need to have mathematical understanding ability (MUA) for a reason, that is, MUA is an important part in problem solving. In fact, MUA of PJHS students was still low. This research was conducted to contribute in improving students’ MUA. There were 158 students engaged in the experiment classroom as well as in the conventional one taken from PJHS 1, 2, and 4 from district of Deli Serdang, PJHS 17 and 22 from Medan City, Indonesia. Joyful problem based learning (JPBL) approach was applied to attain the purpose of the research. The study used essay-test to measure students’ MUA. The score obtained was then analyzed by t-independent test, while student performance in solving MUA problems was described descriptively. Results of the research: (1) Students MUA’ score was higher in the experiment classroom than in the conventional one. (2) The improvement of students MUA in the experiment classroom belongs to medium category. (3) The students’ performance in MUA was better in the JPBL classroom than it was in the conventional one. Some students faced difficulties both in explaining the solution and in giving example of a mathematical concept. Overall, the students’ performance was best at the aspect of presenting problem in mathematics equation. Based on the findings, the study suggests teachers to give reinforcement in both aspect where students lacked of by, for example, encouraging them to solve a variety of problems which eliciting the aspect of explaining and giving examples.
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Lancaster, Sarah T., Thomas N. Grove, and David A. Woods. "Management of post-traumatic stiffness of the shoulder following upper limb trauma with manipulation under anaesthetic." Shoulder & Elbow 9, no. 4 (February 20, 2017): 258–65. http://dx.doi.org/10.1177/1758573217693974.
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Background A proportion of patients who sustain upper limb fractures develop post-traumatic stiffness (PTS), which may progress in a similar way to primary frozen shoulder (PFS). We have had success in treating PFS with manipulation under anaesthetic (MUA) and therefore treated PTS using MUA. Oxford Shoulder Scores (OSS), range of motion (ROM) data pre- and post-MUA, and the need for repeat procedure were compared. Methods Sixty-four patients with PTS following an upper limb fracture, unresponsive to conservative measures, were seen between 1 January 1999 and 1 November 2015. Thirty-two patients had sustained a proximal humeral fracture, six of whom had a concurrent shoulder dislocation. MUA was performed using a standard technique. The results were compared with 487 PFS patients undergoing the same procedure. Results There was no significant difference in ROM change between the groups. Improvement in OSS was slightly greater in the PFS group (17 versus 14, p = 0.005) but, upon subgroup analysis of the PTS group, no significant difference was found for patients presenting with humeral fractures alone. Conclusions MUA results for PTS following upper limb fracture are comparable to MUA for PFS. We therefore recommend MUA in PTS cases where conservative methods have failed.
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Sokk, Jelena, Helena Gapeyeva, Jaan Ereline, Mati Merila, and Mati Pääsuke. "Shoulder Muscle Isometric Strength and Active Range of Motion in Patients With Frozen Shoulder Syndrome After Manipulation Under Anesthesia." Medicina 48, no. 7 (July 7, 2012): 49. http://dx.doi.org/10.3390/medicina48070049.
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Background and Objective. Frozen shoulder syndrome (FSS) causes pain and restriction of movement in the shoulder. The aim was to assess changes in shoulder muscle isometric maximal voluntary contraction (MVC) force and active range of motion (AROM) in patients with frozen shoulder syndrome (FSS) after manipulation under general anesthesia (MUA). Material and Methods. In total, 18 patients with FSS (9 women and 9 men) with a mean age of 53.6 years (SD, 9.7) participated in this study. MVC force of shoulder flexors, adductors, and internal and external rotators was measured by a handheld dynamometer. AROM in the same directions was measured goniometrically. The patients were screened according to the intensity of pain by day and at night. The data were collected before MUA and 1 and 6 months after MUA. A significant reduction in MVC force and AROM was noted before MUA in the involved extremity as compared with the uninvolved extremity (P<0.05). These parameters for the involved extremity were significantly increased 1 month after MUA (P<0.05). However, 6 months after MUA, MVC force and AROM did not differ significantly compared with the uninvolved extremity (P>0.05), whereas AROM of flexion and external rotation remained significantly reduced (P<0.05). A significant reduction in shoulder pain by day and at night was recorded 1 and 6 months after MUA (P<0.05). Conclusions. In the patients with FSS, the fastest improvement of MVC force and AROM occurred following the first month after MUA. However, 6 months after MUA, shoulder muscle MVC force for the involved extremity did not differ significantly as compared with the uninvolved extremity, whereas the shoulder AROM in flexion and external rotation remained lower.
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Bích, Lê Như, Nguyễn Thị Tươi, and Peter J. Batt. "THE EXTENT TO WHICH DOWNSTREAM BUYERS ARE ABLE TO FULFIL FLOWER FARMERS NEEDS IN DALAT." Tạp chí Khoa học Đại học Đà Lạt 6, no. 3 (September 30, 2016): 345. http://dx.doi.org/10.37569/dalatuniversity.6.3.79(2016).
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Nghiên cứu này nhằm tìm kiếm sự khác biệt giữa những gì người sản xuất hoa mong muốn và những gì họ thực sự nhận được từ người mua trong quá trình mua bán tại Đà Lạt, Việt Nam. Nghiên cứu được thực hiện thông qua phỏng vấn trực tiếp 206 nông dân sản xuất hoa cúc và hoa hồng tại Đà Lạt về các tiêu chí lựa chọn người mua hoa và khả năng của người mua đáp ứng yêu cầu của họ. Cả hai tiêu chí kinh tế và mối quan hệ được xác định có ảnh hưởng đến sự lựa chọn người mua hoa của nông dân. Nghiên cứu cũng nhấn mạnh tầm quan trọng của marketing mối quan hệ như một phương tiện để giảm thiểu rủi ro ở các nền kinh tế chuyển đổi.
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Corbacho, Belen, Stephen Brealey, Ada Keding, Gerry Richardson, David Torgerson, Catherine Hewitt, Catriona McDaid, and Amar Rangan. "Cost-effectiveness of surgical treatments compared with early structured physiotherapy in secondary care for adults with primary frozen shoulder." Bone & Joint Open 2, no. 8 (August 1, 2021): 685–95. http://dx.doi.org/10.1302/2633-1462.28.bjo-2021-0075.r1.
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Aims A pragmatic multicentre randomized controlled trial, UK FROzen Shoulder Trial (UK FROST), was conducted in the UK NHS comparing the cost-effectiveness of commonly used treatments for adults with primary frozen shoulder in secondary care. Methods A cost utility analysis from the NHS perspective was performed. Differences between manipulation under anaesthesia (MUA), arthroscopic capsular release (ACR), and early structured physiotherapy plus steroid injection (ESP) in costs (2018 GBP price base) and quality adjusted life years (QALYs) at one year were used to estimate the cost-effectiveness of the treatments using regression methods. Results ACR was £1,734 more costly than ESP ((95% confidence intervals (CIs) £1,529 to £1,938)) and £1,457 more costly than MUA (95% CI £1,283 to £1,632). MUA was £276 (95% CI £66 to £487) more expensive than ESP. Overall, ACR had worse QALYs compared with MUA (-0.0293; 95% CI -0.0616 to 0.0030) and MUA had better QALYs compared with ESP (0.0396; 95% CI -0.0008 to 0.0800). At a £20,000 per QALY willingness-to-pay threshold, MUA had the highest probability of being cost-effective (0.8632) then ESP (0.1366) and ACR (0.0002). The results were robust to sensitivity analyses. Conclusion While ESP was less costly, MUA was the most cost-effective option. ACR was not cost-effective. Cite this article: Bone Jt Open 2021;2(8):685–695.
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Chalmers, Brian P., Enrique Goytizolo, Mithun D. Mishu, and Geoffrey H. Westrich. "Manipulation under anaesthesia after primary total knee arthroplasty." Bone & Joint Journal 103-B, no. 6 Supple A (June 1, 2021): 126–30. http://dx.doi.org/10.1302/0301-620x.103b6.bjj-2020-1950.r1.
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Aims Manipulation under anaesthesia (MUA) remains an effective intervention to address restricted range of motion (ROM) after total knee arthroplasty (TKA) and occurs in 2% to 3% of primary TKAs at our institution. Since there are few data on the outcomes of MUA with different anaesthetic methods, we sought to compare the outcomes of patients undergoing MUA with intravenous (IV) sedation and neuraxial anaesthesia. Methods We identified 548 MUAs after primary TKA (136 IV sedation, 412 neuraxial anaesthesia plus IV sedation) from March 2016 to July 2019. The mean age of this cohort was 62 years (35 to 88) with a mean body mass index of 31 kg/m2 (18 to 49). The mean time from primary TKA to MUA was 10.2 weeks (6.2 to 24.3). Pre-MUA ROM was similar between groups; overall mean pre-MUA extension was 4.2° (p = 0.452) and mean pre-MUA flexion was 77° (p = 0.372). We compared orthopaedic complications, visual analogue scale (VAS) pain scores, length of stay (LOS), and immediate and three-month follow-up knee ROM between these groups. Results Following MUA, patients with IV sedation had higher mean VAS pain scores of 5.2 (SD 1.8) compared to 4.1 (SD = 1.5) in the neuraxial group (p < 0.001). The mean LOS was shorter in patients that received IV sedation (9.5 hours (4 to 31)) compared to neuraxial anaesthesia (11.9 hours (4 to 51)) (p = 0.009), but an unexpected overnight stay was similar in each group (8.6%). Immediate-post MUA ROM was 1° to 121° in the IV sedation group and 0.9° to 123° in the neuraxial group (p = 0.313). Three-month follow-up ROM was 2° to 108° in the IV sedation group and 1.9° to 110° in the neuraxial anaesthesia group (p = 0.325) with a mean loss of 13° (ranging from 5° gain to 60° loss), in both groups by three months. No patients in either group sustained a complication. Conclusion IV sedation alone and neuraxial anaesthesia are both effective anaesthetic methods for MUA after primary TKA. Surgeons and anaesthetists should offer these anaesthetic techniques to match patient-specific needs as the orthopaedic outcomes are similar. Also, patients should be counselled that ROM following MUA may decrease over time. Cite this article: Bone Joint J 2021;103-B(6 Supple A):126–130.
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Goubillon, Marie-Laure, Jean-Marc Kaufman, and Jean-Christophe Thalabard. "Hypothalamic multiunit activity and pulsatile luteinizing hormone release in the castrated male rat." European Journal of Endocrinology 133, no. 5 (November 1995): 585–90. http://dx.doi.org/10.1530/eje.0.1330585.
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Goubillon M-L, Kaufman J-M, Thalabard J-C. Hypothalamic multiunit activity and pulsatile luteinizing hormone release in the castrated male rat. Eur J Endocrinol 1995:133:585–90. ISSN 0804–4643 Using chronically implanted microelectrodes, multiunit electrical activity (MUA) was recorded from the arcuate nucleus of freely moving gonadectomized male rats. Intermittent increases in MUA activity (MUA volleys) closely associated with luteinizing hormone pulses measured in the peripheral circulation were observed, which confirms that this experimental approach can be used for monitoring the activity of the gonadotropin-releasing hormone-associated hypothalamic pulse generator in the male rat. The mean MUA volley frequency was 22.2 min (range 13–38 min), whereas the mean MUA volley duration was 2.7 ± 0.8 min (standard deviation). In addition to a large inter-individual variability, MUA volley intervals also showed an important intra-individual variability. This observation suggests that, beside the mean frequency of pulse generator activation, the degree of variability in gonadotropin-releasing hormone-associated pulse generator activity might be an additional relevant parameter in the characterization of the reproductive function in the male rat. M-L Goubillon, Laboratoire d'Histologie et d'Embryologie, Faculté de Médecine, CNRS URA 1454, 69600 Oullins, France
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Grubb, B. R., A. M. Paradiso, and R. C. Boucher. "Anomalies in ion transport in CF mouse tracheal epithelium." American Journal of Physiology-Cell Physiology 267, no. 1 (July 1, 1994): C293—C300. http://dx.doi.org/10.1152/ajpcell.1994.267.1.c293.
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The cystic fibrosis (CF) mouse trachea has become a model for gene transfer. To characterize ion transport properties of tracheal epithelium from normal and CF mice, tracheas were excised, mounted in Ussing chambers, and basal properties and responses to pharmacological agents and/or ion substitution protocols measured. No difference in basal short-circuit (Isc) was observed between normal (29.1 +/- 3.8 muA/cm2, n = 21) and CF (34.7 +/- 4.5 muA/cm2, n = 16) tracheas. The relative contribution of Na+ transport to basal Isc was small (30-40%). Ionomycin stimulated large increases in Isc in both normal and CF murine tracheas [change in Isc (delta Isc) with ionomycin: 30.5 +/- 8.8 muA/cm2, n = 11, normal; 27.3 +/- 6.7 muA/cm2, n = 6, CF]. Unexpectedly, forskolin increased Isc in both CF and normal amiloride-pretreated tracheas (delta Isc: 10.5 +/- 2.1 muA/cm2, n = 21, normal; 13 +/- 2.3 muA/cm2, n = 16, CF). Forskolin was observed to increase intracellular Ca2+ in both normal and CF tracheal cells, suggesting this as a mechanism to induce Cl- secretion. These similarities in ion transport, in part reflecting the dominance of Ca(2+)-regulated Cl- conductance, suggest that the murine trachea is not an ideal target for assessment of CF correction by gene transfer.
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Phụng, Nguyễn Thị, and Nguyễn Thị Hồng Nhung. "Các yếu tố digital marketing tác động đến hành vi mua căn hộ chung cư tại thành phố Hồ Chí Minh." PROCEEDINGS 16, no. 1 (April 28, 2021): 44–58. http://dx.doi.org/10.46223/hcmcoujs.proc.vi.16.1.1855.2021.
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Nghiên cứu này nhằm phân tích các yếu tố Digital Marketing tác động đến hành vi mua căn hộ chung cư tại thành phố Hồ Chí Minh. Qua thực hiện khảo sát trực tuyến và trực tiếp, nhóm nghiên cứu thu thập thông tin đối với 265 khách hàng về “Tác động Digital Marketing đến hành vi mua căn hộ chung cư tại thành phố Hồ Chí Minh” đến từ các công ty bất động sản. Kết quả phân tích dữ liệu cho thấy có 06 yếu tố tác động đến hành vi mua căn hộ chung cư, đó là Social Media Marketing; Content Marketing; Search Engine Marketing; Online Public Relations; Affiliate Marketing; E-Mail Marketing trong đó yếu tố Social Media Marketing có tác động mạnh nhất đến hành vi mua của khách hàng. Kết quả nghiên cứu sẽ là những thông tin hữu ích cho Doanh nghiệp để khai thác triệt để các phương tiện Digital Marketing nhằm thúc đẩy hành vi mua của người tiêu dùng đối với thị trường căn hộ chung cư tại thành phố Hồ Chí Minh.
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Lesevic, Milos, John T. Awowale, Thomas E. Moran, David R. Diduch, Stephen F. Brockmeier, and Brian C. Werner. "Immediate Pain Relief at Time of Corticosteroid Injection for Idiopathic Adhesive Capsulitis as a Predictor of Eventual Outcomes." Orthopaedic Journal of Sports Medicine 9, no. 7 (July 1, 2021): 232596712110193. http://dx.doi.org/10.1177/23259671211019353.
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Background: Corticosteroid injection and physical therapy remain the mainstay of treatment for idiopathic adhesive capsulitis of the shoulder; however, a certain percentage of patients will not improve using these interventions and will require manipulation under anesthesia (MUA) and/or lysis of adhesions (LOA). Purpose: To evaluate whether the immediate pain reduction after fluoroscopic-guided, mixed anesthetic-corticosteroid injection for idiopathic adhesive capsulitis is related to the eventual need for LOA/MUA or a repeat glenohumeral steroid injection. Study Design: Case-control study; Level of evidence, 3. Methods: This single-institution study involved patients undergoing fluoroscopic glenohumeral corticosteroid injection for a diagnosis of idiopathic adhesive capsulitis between 2010 and 2017. Included were patients with a minimum of 1-year postinjection follow-up and visual analog scale (VAS) pain scores from immediately before and after the injection. The primary analysis was the relationship between patients with an immediate change in VAS score after injection and those who underwent LOA/MUA. A repeat glenohumeral injection was also evaluated as an outcome. Receiver operator characteristic curves and a multivariate binomial logistic regression analysis were performed. Results: Overall, 739 shoulders in 728 patients (mean age, 52.6 years; 68% women) were included, of which 38 (5.1%) underwent LOA/MUA and 209 (28%) underwent repeat injections. The immediate change in the VAS score was not significantly associated with the eventual need for LOA/MUA. Preinjection VAS and immediate postinjection VAS scores were not significant predictors of eventual LOA/MUA or subsequent injection. For all 3 predictors, the area under the receiver operator characteristic curve classified them as extremely poor discriminators. Conclusion: The immediate pain response to a fluoroscopic-guided glenohumeral injection for idiopathic shoulder adhesive capsulitis was not predictive of the eventual need for LOA/MUA or subsequent injection. Patients can be counseled that even if their initial pain response to an injection is poor, they still have an excellent chance of avoiding surgery, as the overall rate of LOA/MUA was low (5.1%).
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Rex, Saleema S., Lucksy Kottam, Catriona McDaid, Stephen Brealey, Joseph Dias, Catherine E. Hewitt, Ada Keding, Sarah E. Lamb, Kath Wright, and Amar Rangan. "Effectiveness of interventions for the management of primary frozen shoulder." Bone & Joint Open 2, no. 9 (September 1, 2021): 773–84. http://dx.doi.org/10.1302/2633-1462.29.bjo-2021-0060.r1.
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Aims This systematic review places a recently completed multicentre randomized controlled trial (RCT), UK FROST, in the context of existing randomized evidence for the management of primary frozen shoulder. UK FROST compared the effectiveness of pre-specified physiotherapy techniques with a steroid injection (PTSI), manipulation under anaesthesia (MUA) with a steroid injection, and arthroscopic capsular release (ACR). This review updates a 2012 review focusing on the effectiveness of MUA, ACR, hydrodilatation, and PTSI. Methods MEDLINE, Embase, PEDro, Science Citation Index, Clinicaltrials.gov, CENTRAL, and the World Health Organization (WHO) International Clinical Trials Registry were searched up to December 2018. Reference lists of included studies were screened. No language restrictions applied. Eligible studies were RCTs comparing the effectiveness of MUA, ACR, PTSI, and hydrodilatation against each other, or supportive care or no treatment, for the management of primary frozen shoulder. Results Nine RCTs were included. The primary outcome of patient-reported shoulder function at long-term follow-up (> 6 months and ≤ 12 months) was reported for five treatment comparisons across four studies. Standardized mean differences (SMD) were: ACR versus MUA: 0.21 (95% confidence interval (CI) 0.00 to 0.42), ACR versus supportive care: -0.13 (95% CI -1.10 to 0.83), and ACR versus PTSI: 0.33 (95% CI 0.07 to 0.59) and 0.25 (95% CI -0.34 to 0.85), all favouring ACR; MUA versus supportive care: 0 (95% CI -0.44 to 0.44) not favouring either; and MUA versus PTSI: 0.12 (95% CI -0.14 to 0.37) favouring MUA. None of these differences met the threshold of clinical significance agreed for the UK FROST and most confidence intervals included zero. Conclusion The findings from a recent multicentre RCT provided the strongest evidence that, when compared with each other, neither PTSI, MUA, nor ACR are clinically superior. Evidence from smaller RCTs did not change this conclusion. The effectiveness of hydrodilatation based on four RCTs was inconclusive and there remains an evidence gap. Cite this article: Bone Jt Open 2021;2(9):773–784.
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Leung, A. Y., P. Y. Wong, J. R. Yankaskas, and R. C. Boucher. "cAMP- but not Ca(2+)-regulated Cl- conductance is lacking in cystic fibrosis mice epididymides and seminal vesicles." American Journal of Physiology-Cell Physiology 271, no. 1 (July 1, 1996): C188—C193. http://dx.doi.org/10.1152/ajpcell.1996.271.1.c188.
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Cystic fibrosis (CF) reflects the loss of adenosine 3',5'-cyclic monophosphate (cAMP)-regulated Cl- secretion consequent to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In humans, but not mice, with CF, the disease is associated with male infertility. The present study investigated the relative magnitudes of the cAMP pathways and an alternative Ca(2+)-regulated Cl- secretory pathway in primary cultures of the epididymides and the seminal vesicles of normal and CF mice. The basal equivalent short-circuit currents (Ieq) of cultures derived from the epididymides and the seminal vesicles from the CF mice were lower (6.0 +/- 0.6 and 4.0 +/- 1.0 muA/cm2, respectively) than those from normal mice (11.1 +/- 1.0 and 6.6 +/- 0.6 muA/cm2, respectively). Forskolin induced significant Ieq responses in both the epididymis (8.0 +/- 0.7 muA/cm2) and seminal vesicles (4.0 +/- 0.5 muA/cm2) from normal mice, whereas forskolin-induced changes in Ieq in CF mouse epididymis and seminal vesicles were absent, consistent with defective cAMP-CFTR-mediated Cl- secretion in CF mice. Ieq responses to agonists (ionomycin, ATP) that raise intracellular Ca2+ (Ca2+i) were larger than forskolin responses in normal animals (6.6 +/- 0.9 and 13.4 +/- 1.8 muA/cm2, respectively) and were preserved in CF (6.5 +/- 0.9 and 17.1 +/- 1.0 muA/cm2, respectively). We speculate that the fertility of male CF mice is maintained by persistent expression of the predominant alternative Ca(2+)-mediated Cl- transport system in the epididymides and seminal vesicles.
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Bercher, Mark, Jim Wahl, Bruce E. Vogel, Charles Lu, Edward M. Hedgecock, David H. Hall, and John D. Plenefisch. "mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes." Journal of Cell Biology 154, no. 2 (July 23, 2001): 415–26. http://dx.doi.org/10.1083/jcb.200103035.
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Normal locomotion of the nematode Caenorhabditis elegans requires transmission of contractile force through a series of mechanical linkages from the myofibrillar lattice of the body wall muscles, across an intervening extracellular matrix and epithelium (the hypodermis) to the cuticle. Mutations in mua-3 cause a separation of the hypodermis from the cuticle, suggesting this gene is required for maintaining hypodermal–cuticle attachment as the animal grows in size postembryonically. mua-3 encodes a predicted 3,767 amino acid protein with a large extracellular domain, a single transmembrane helix, and a smaller cytoplasmic domain. The extracellular domain contains four distinct protein modules: 5 low density lipoprotein type A, 52 epidermal growth factor, 1 von Willebrand factor A, and 2 sea urchin-enterokinase-agrin modules. MUA-3 localizes to the hypodermal hemidesmosomes and to other sites of mechanically robust transepithelial attachments, including the rectum, vulva, mechanosensory neurons, and excretory duct/pore. In addition, it is shown that MUA-3 colocalizes with cytoplasmic intermediate filaments (IFs) at these sites. Thus, MUA-3 appears to be a protein that links the IF cytoskeleton of nematode epithelia to the cuticle at sites of mechanical stress.
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Kraal, Tim, Lijkele Beimers, Bertram The, Inger Sierevelt, Michel van den Bekerom, and Denise Eygendaal. "Manipulation under anaesthesia for frozen shoulders: outdated technique or well-established quick fix?" EFORT Open Reviews 4, no. 3 (March 2019): 98–109. http://dx.doi.org/10.1302/2058-5241.4.180044.
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Manipulation under anaesthesia (MUA) for frozen shoulder (FS) leads to a considerable increase in range of motion and Oxford shoulder score, a significant reduction in pain and around 85% satisfaction. A clearly defined indication for MUA in FS patients cannot be extracted from this review or the available literature. The associating criteria before proceeding to MUA vary widely. All but one study in this review lacked a control group without intervention. Therefore, firm conclusions about the role of MUA in the treatment of FS cannot be drawn from the current literature. An overall complication rate of 0.4% was found and a re-intervention rate of 14%, although most of the included papers were not designed to monitor complications. The following criteria before proceeding to MUA are proposed: a patient unable to cope with a stiff and painful shoulder; clinical signs of a stage 2 idiopathic FS; lessening pain in relation to stage 1; external rotation < 50% compared to contralateral shoulder joint; a minimal duration of symptoms of three months; and failure to respond to an intra-articular corticosteroid infiltration. Cite this article: EFORT Open Rev 2019;4:98-109. DOI: 10.1302/2058-5241.4.180044
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Ishak, Mohamad Nizam, K. A. Yaacob, and Ahmad Fauzi Mohd Noor. "The Effect of Ligands on CdSe Nanoparticle Films Deposited by EPD." Advanced Materials Research 1087 (February 2015): 304–8. http://dx.doi.org/10.4028/www.scientific.net/amr.1087.304.
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Nanoparticle from group II-IV semiconductor nanoparticles is widely studied for solar cells. The ability to modify the surface of nanoparticle is significant to successful use in various applications. In this research, mercaptoundecionic acid (MUA) and trioctyl phosphine oxide (TOPO) were used as ligand for cadmium selenide (CdSe) nanoparticles. The wavelength shift to a shorter value observed due to decreasing size of CdSe nanoparticle after ligand exchange from TOPO to MUA. The electrophoretic deposition methods (EPD) have being employed to deposite CdSe nanoparticles films on fluorine doped tin oxide (FTO). The deposition voltages used are between 100 - 400 V for 15 minutes. From SEM results show the formation layer of CdSe nanoparticles capped with MUA is strong and porous as compared to CdSe nanoparticle capped with TOPO. MUA capped CdSe shows better cell efficiency compared to TOPO capped CdSe which is 0.1735 %.
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Carstensen, S. Evan, Scott M. Feeley, and David R. Diduch. "Manipulation Under Anesthesia With Lysis of Adhesions Is Effective in Arthrofibrosis After Sulcus-Deepening Trochleoplasty: A Prospective Study." Orthopaedic Journal of Sports Medicine 7, no. 8 (August 2019): 232596711986486. http://dx.doi.org/10.1177/2325967119864868.
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Background: Sulcus-deepening trochleoplasty has been established as an effective treatment for patellar instability due to trochlear dysplasia. However, arthrofibrosis is a known complication following trochleoplasty, which may require manipulation under anesthesia (MUA) with or without lysis of adhesions (LOA) to increase the knee range of motion (ROM), especially flexion. Purpose: To prospectively follow patients for ROM improvements and subsequent complications after undergoing MUA with or without LOA in the setting of sulcus-deepening trochleoplasty. Study Design: Case series; Level of evidence, 4. Methods: A total of 76 knees with severe trochlear dysplasia were prospectively enrolled and underwent sulcus-deepening trochleoplasty, with a mean (±SD) follow-up of 32.5 ± 19.3 months. Concomitant procedures included medial patellofemoral ligament reconstruction, lateral retinacular release, and tibial tubercle osteotomy. Physical examination including ROM and findings of recurrent patellar instability were collected for all patients. Arthrofibrosis was defined as active and passive flexion less than 90° within 3 months of surgery combined with a plateau in progress with physical therapy. Paired-samples and independent-samples t tests were used. A P value less than .05 was considered significant. Results: A total of 62 knees met inclusion and exclusion criteria and were included in the study. Of these patients, 11 experienced arthrofibrosis as a complication and underwent MUA within 3 months of their index procedure. Of these 11 patients, 9 subsequently underwent arthroscopic LOA following MUA because acceptable ROM could not be achieved with manipulation alone. Patients with arthrofibrosis had a premanipulation mean ROM that was significantly different from those without arthrofibrosis (77.3° ±18.6° vs 133.3° ± 12.7°, respectively; P < .001). In the arthrofibrotic group, postoperative ROM increased significantly after MUA and/or LOA compared with the preoperative ROM (127.3° ± 12.5° vs 77.3° ± 18.6°, respectively; P < .001). ROM in the arthrofibrotic group after MUA/LOA was not significantly different from that in the nonarthrofibrotic group (flexion, 127.3° ± 12.5° vs 133.3° ± 12.7°, respectively; P = .156). No complications from the MUA or LOA were reported at subsequent follow-up visits. Conclusion: When indicated in the setting of severe trochlear dysplasia, sulcus-deepening trochleoplasty is a treatment for disabling recurrent patellar instability with a known complication of arthrofibrosis. Initiation of postoperative physical therapy within 3 days of surgery may reduce the incidence of arthrofibrosis. If arthrofibrosis is encountered after a sulcus-deepening trochleoplasty, MUA without LOA is not as effective as when following other procedures of the knee, whereas MUA with LOA is an effective procedure likely to result in ROM and patient outcome scores similar to those of a nonarthrofibrotic knee after the same procedure. Both MUA and LOA appear to be safe based on the limited number of patients in this study without complication.
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Bos, Michael J., Ana Maria Alzate Sanchez, Raffaella Bancone, Yasin Temel, Bianca T. A. de Greef, Anthony R. Absalom, Erik D. Gommer, et al. "Influence of Anesthesia and Clinical Variables on the Firing Rate, Coefficient of Variation and Multi-Unit Activity of the Subthalamic Nucleus in Patients with Parkinson’s Disease." Journal of Clinical Medicine 9, no. 4 (April 24, 2020): 1229. http://dx.doi.org/10.3390/jcm9041229.
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Background: Microelectrode recordings (MER) are used to optimize lead placement during subthalamic nucleus deep brain stimulation (STN-DBS). To obtain reliable MER, surgery is usually performed while patients are awake. Procedural sedation and analgesia (PSA) is often desirable to improve patient comfort, anxiolysis and pain relief. The effect of these agents on MER are largely unknown. The objective of this study was to determine the effects of commonly used PSA agents, dexmedetomidine, clonidine and remifentanil and patient characteristics on MER during DBS surgery. Methods: Data from 78 patients with Parkinson’s disease (PD) who underwent STN-DBS surgery were retrospectively reviewed. The procedures were performed under local anesthesia or under PSA with dexmedetomidine, clonidine or remifentanil. In total, 4082 sites with multi-unit activity (MUA) and 588 with single units were acquired. Single unit firing rates and coefficient of variation (CV), and MUA total power were compared between patient groups. Results: We observed a significant reduction in MUA, an increase of the CV and a trend for reduced firing rate by dexmedetomidine. The effect of dexmedetomidine was dose-dependent for all measures. Remifentanil had no effect on the firing rate but was associated with a significant increase in CV and a decrease in MUA. Clonidine showed no significant effect on firing rate, CV or MUA. In addition to anesthetic effects, MUA and CV were also influenced by patient-dependent variables. Conclusion: Our results showed that PSA influenced neuronal properties in the STN and the dexmedetomidine (DEX) effect was dose-dependent. In addition, patient-dependent characteristics also influenced MER.
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Feng, James E., Afshin A. Anoushiravani, Jacob Ziegler, Ran Schwarzkopf, and William J. Long. "Manipulation under Anesthesia: Does Polyethylene Thickness Matter?" Journal of Knee Surgery 32, no. 11 (November 10, 2018): 1088–93. http://dx.doi.org/10.1055/s-0038-1675403.
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AbstractTotal knee arthroplasty (TKA) has been established as the most effective treatment for end-stage, symptomatic osteoarthritis of the knee. However, improper polyethylene size selection has been proposed to predispose patients to postoperative stiffness following TKA. The aim of this study is to evaluate if there is a correlation between the use of the thinnest tibial implant thickness and implant manufacturer with the likelihood of undergoing manipulation under anesthesia (MUA). A retrospective review of unilateral TKAs performed between January 2012 and November 2015 was performed. Each knee implant system was normalized by total tibial component thickness for each individual implant system (metal back plus polyethylene) and reaggregated to assess the difference in MUA rates when comparing the thinnest tibial component thickness against the next two sizes. Subset analysis was performed comparing the thinnest tibial component thickness for each individual implant system versus (1) all other tibial component sizes and (2) tibial components one and two sizes larger. A total of 2,728 patients were retrospectively evaluated, of which 71 (2.60%) underwent MUA. Combined tibial component thickness ranged from 8 to 21 mm. When aggregated together to compare the MUA rate between the thinnest liner and the next two sizes, no statistically significant difference was observed (p = 1). Subset analysis demonstrated inconsistent significant differences in MUA rates. Our results suggest that the polyethylene liner thickness alone is not a predictor of postoperative knee stiffness necessitating MUA. When selecting a polyethylene liner, a proper fit maximizing flexion/extension stability is the most crucial factor.
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Sanganahalli, Basavaraju G., Peter Herman, Douglas L. Rothman, Hal Blumenfeld, and Fahmeed Hyder. "Metabolic demands of neural-hemodynamic associated and disassociated areas in brain." Journal of Cerebral Blood Flow & Metabolism 36, no. 10 (August 25, 2016): 1695–707. http://dx.doi.org/10.1177/0271678x16664531.
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Interpretation of regional blood oxygenation level-dependent (BOLD) responses in functional magnetic resonance imaging (fMRI) is contingent on whether local field potential (LFP) and multi-unit activity (MUA) is either dissociated or associated. To examine whether neural-hemodynamic associated and dissociated areas have different metabolic demands, we recorded sensory-evoked responses of BOLD signal, blood flow (CBF), and blood volume (CBV), which with calibrated fMRI provided oxidative metabolism (CMRO2) from rat’s ventral posterolateral thalamic nucleus (VPL) and somatosensory forelimb cortex (S1FL) and compared these neuroimaging signals to neurophysiological recordings. MUA faithfully recorded evoked latency differences between VPL and S1FL because evoked MUA in these regions were similar in magnitude. Since evoked LFP was significantly attenuated in VPL, we extracted the time courses of the weaker thalamic LFP to compare with the stronger cortical LFP using wavelet transform. BOLD and CBV responses were greater in S1FL than in VPL, similar to LFP regional differences. CBF and CMRO2 responses were both comparably larger in S1FL and VPL. Despite different levels of CBF-CMRO2 and LFP-MUA couplings in VPL and S1FL, the CMRO2 was well matched with MUA in both regions. These results suggest that neural-hemodynamic associated and dissociated areas in VPL and S1FL can have similar metabolic demands.
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David, Bruno, Ian McNiven, Louise Manas, John Manas, Saila Savage, Joe Crouch, Guy Neliman, and Liam Brady. "Goba of Mua: archaeology working with oral tradition." Antiquity 78, no. 299 (March 2004): 158–72. http://dx.doi.org/10.1017/s0003598x00093005.
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A team of Elders and community officials from the island of Mua in the Torres Straits got together with archaeologists from Australia to study an episode which occurred on the island before the coming of Christianity in 1871. Oral tradition located the burial place of the father of an ancestral islander named Goba, and the investigation of a rock shelter nearby gave a dated sequence of occupation and a fresh sighting of rock paintings, all relating to the period. Each type of evidence gave context to the other, and the project offered a vivid example of how history is fashioned.
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Goldhaber-Gordon, Ilana, Michael H. Early, and Tania A. Baker. "MuA Transposase Separates DNA Sequence Recognition from Catalysis†." Biochemistry 42, no. 49 (December 2003): 14633–42. http://dx.doi.org/10.1021/bi035360o.
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Anand, N., and L. Klenerman. "Ankle fractures in the elderly: MUA versus ORIF." Injury 24, no. 2 (February 1993): 116–20. http://dx.doi.org/10.1016/0020-1383(93)90202-h.
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Siddappa Malleshappa, Sudeep K., Smith Giri, Smit Patel, Tapan Mehta, Leonard Appleman, Scott F. Huntington, Vida Passero, Rahul A. Parikh, and Kathan D. Mehta. "Overall survival based on oncologist density in the United States: A retrospective cohort study." PLOS ONE 16, no. 5 (May 12, 2021): e0250894. http://dx.doi.org/10.1371/journal.pone.0250894.
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Medically underserved areas (MUA) or health professional shortage areas (HPSA) designations are based on primary care health services availability. These designations are used in recruiting international medical graduates (IMGs) trained in primary care or subspecialty (e.g., oncology) to areas of need. Whether the MUA/HPSA designation correlates with Oncologist Density (OD) and supports IMG oncologists’ recruitment to areas of need is unknown. We evaluated the concordance of OD with the designation of MUAs/HPSAs and evaluated the impact of OD and MUA/HPSA status on overall survival. We conducted a retrospective cohort study of patients diagnosed with hematological malignancies or metastatic solid tumors in 2011 from the Surveillance Epidemiology and End Results (SEER) database. SEER was linked to the American Medical Association Masterfile to calculate OD, defined as the number of oncologists per 100,000 population at the county level. We calculated the proportion of counties with MUA or HPSA designation for each OD category. Overall survival was estimated using the Kaplan-Meier method and compared between the OD category using a log-rank test. We identified 68,699 adult patients with hematologic malignancies or metastatic solid cancers in 609 counties. The proportion of MUA/HPSA designation was similar across counties categorized by OD (93.2%, 95.4%, 90.3%, and 91.7% in counties with <2.9, 2.9–6.5, 6.5–8.4 and >8.4 oncologists per 100K population, p = 0.7). Patients’ median survival in counties with the lowest OD was significantly lower compared to counties with the highest OD (8 vs. 11 months, p<0.0001). The difference remained statistically significant in multivariate and subgroup analysis. MUA/HPSA status was not associated with survival (HR 1.03, 95%CI 0.97–1.09, p = 0.3). MUA/HPSA designation based on primary care services is not concordant with OD. Patients in counties with lower OD correlated with inferior survival. Federal programs designed to recruit physicians in high-need areas should consider the availability of health care services beyond primary care.
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Malahias, Michael-Alexander, Lauren Wessel, Shawn Richardson, Teresa Doerre, Seth Stake, Peter Sculco, Scott Rodeo, Scott Kaar, and Alex Gu. "Anticoagulant Usage Following Anterior Cruciate Ligament Reconstruction is Associated with Increased Rate of Manipulation Under Anesthesia." Orthopaedic Journal of Sports Medicine 8, no. 7_suppl6 (July 1, 2020): 2325967120S0048. http://dx.doi.org/10.1177/2325967120s00488.
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Objectives: Although uncommon, arthrofibrosis following anterior cruciate ligament reconstruction (ACLR) is considered to be a significant and disabling complication for a young, athletic population. In this study, we aimed to determine: (1) the prevalence of manipulation under anesthesia (MUA) for treatment of arthrofibrosis following ACLR (2) whether anticoagulant use following ACLR is associated with an increased risk of MUA. We anticipate that postoperative use of anticoagulants will be associated with an increased risk of subsequent MUA. Methods: A retrospective cohort study was conducted using data collected from the Humana insurance database using the PearlDiver Patient Records Database from 2007-2017. Subjects were identified using Current Procedural Terminology (CPT) and International Classification of Diseases (ICD) codes. Patients were initially identified by ACL sprain or tear diagnosis utilizing ICD codes. Patients who underwent a concomitant MCL, PCL or LCL repair or reconstruction were excluded from this analysis. Patients who underwent MUA within one year of ACLR were then identified. Patient demographic characteristics including age, sex, and Charlson Comorbidity Index (CCI) were recorded. In addition, previously identified risk factors for knee stiffness were collected, including history of diabetes mellitus and obesity. Lastly, the time between ACL tear and surgery and ACL reconstruction to MUA were collected and categorized into 2 groups: (1) <4 weeks and (2) >4 weeks. Anticoagulants included in this analysis were warfarin, aspirin, low-molecular-weight heparin, direct factor Xa inhibitors and fondaparinux. Patient demographics, comorbidities, timing to surgery, concomitant meniscal repair, and postoperative complications were analyzed with a logistic multivariate analysis to determine adjusted associations of risk factors of arthrofibrosis. A p-value of < 0.05 was used as the cutoff for statistical significance. Results: There were 7,798 patients who met the inclusion criteria for this analysis. 115 (1.5%) patients received a subsequent MUA within one-year, while 7,683 (98.5%) patients did not. Among patients who underwent ACLR, 234 (3.0%) patients were on anticoagulants postoperatively. Patients who were on anticoagulants following ACLR were more likely to require an MUA (OR: 4.626; 95% CI: 2.462-8.093; p<0.001; Table 1). Other risk factors for MUA are listed in Table 1. Conclusion: The key finding of this study was that the use of anticoagulants is associated with increased rates of MUA following ACLR. One potential mechanism for the effect of anticoagulants may be the increased risk of postoperative hematoma. Recurrent hematoma has been suggested as a risk factor for arthrofibrosis requiring MUA following ACLR due to increased vascular micro-permeability that anticoagulants can produce. The presence of blood products in the joint may stimulate the accumulation of inflammatory mediators and subsequent fibrosis, as it is well-established that unresolved inflammation can initiate and propagate scar tissue formation. In conclusion, arthrofibrosis after ACLR is associated with postoperative use of thromboprophylaxis. Healthcare providers should be cognizant of this risk when considering anticoagulant usage in this patient population.
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Abd. Rahman, Samsulida, Nurhayati Ariffin, Nor Azah Yusof, Jaafar Abdullah, Zuhana Ahmad Zubir, Nik Mohd Azmi Nik Abdul Aziz, Nur Ellina Azmi, Hamidah Sidek, and Noor Izaanin Ramli. "Synthesis and Surface Modification of Biocompatible Water Soluble Core-Shell Quantum Dots." Advanced Materials Research 879 (January 2014): 184–90. http://dx.doi.org/10.4028/www.scientific.net/amr.879.184.
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In this study, the applications of CdSe/ZnS quantum dots (QDs) and its role in advanced sensings has been explored. The CdSe/ZnS was synthesized by using hot injection method with the shell ZnS layer was made using successive ionic layer adsorption and reaction (SILAR) method. The morphology of the CdSe/ZnS QDs was studied using Transmission Electron Microscope (TEM) and the average particle size was in 10-12 nm range. The prepared QDs were optically characterized using spectrofluorescence and strong emission was observed at 620 nm. Comparison of the fluorescence emissions of CdSe/ZnS capped with various capping ligands such as L-cysteine, thioglycolic acid (TGA), mercaptopropionic acid (MPA), mercaptosuccinic acid (MSA) and mercaptoundecanoic acid (MUA) were studied. The CdSe/ZnS capped with TGA gave the strongest fluorescence emission compared to others.
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Kim, Hodong, Hyundo Yoon, Youngjoo Shin, and Junbeom Hur. "On the Security of Practical Mail User Agents against Cache Side-Channel Attacks." Applied Sciences 10, no. 11 (May 29, 2020): 3770. http://dx.doi.org/10.3390/app10113770.
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Mail user agent (MUA) programs provide an integrated interface for email services. Many MUAs support email encryption functionality to ensure the confidentiality of emails. In practice, they encrypt the content of an email using email encryption standards such as OpenPGP or S/MIME, mostly implemented using GnuPG. Despite their widespread deployment, there has been insufficient research on their software structure and the security dependencies among the software components of MUA programs. In order to understand the security implications of the structures and analyze any possible vulnerabilities of MUA programs, we investigated a number of MUAs that support email encryption. As a result, we found severe vulnerabilities in a number of MUAs that allow cache side-channel attacks in virtualized desktop environments. Our analysis reveals that the root cause originates from the lack of verification and control over the third-party cryptographic libraries that they adopt. In order to demonstrate this, we implemented a cache side-channel attack on RSA in GnuPG and then conducted an evaluation of the vulnerability of 13 MUAs that support email encryption in Ubuntu 14.04, 16.04 and 18.04. Based on our experiment, we found that 10 of these MUA programs (representing approximately 77% of existing MUA programs) allow the installation of a vulnerable version of GnuPG, even when the latest version of GnuPG, which is secure against most cache side-channel attacks, is in use. In order to substantiate the importance of the vulnerability we discovered, we conducted a FLUSH+RELOAD attack on these MUA programs and demonstrated that the attack restored 92% of the bits of the 2048-bit RSA private key when the recipients read a single encrypted email.
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Duensing, Ian, Christopher L. Peters, Priscila Monteiro, Mike B. Anderson, and Christopher E. Pelt. "Higher incidence of manipulation under anesthesia following TKA associated with the periarticular infiltration of a liposomal bupivacaine cocktail compared to a modified Ranawat cocktail." Journal of Orthopaedic Surgery 28, no. 1 (January 1, 2020): 230949902091081. http://dx.doi.org/10.1177/2309499020910816.
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Background: The purpose of this study was to compare the frequency of postoperative stiffness requiring manipulation under anesthesia (MUA) before and after switching from the intraoperative use of liposomal bupivacaine (LB). Methods: This was an institutional review board (IRB)-exempt retrospective cohort study (IRB#71733) on all patients who underwent primary total knee arthroplasty (TKA) by a single surgeon between April 2016 and December 2017. We compared 169 knees that received LB group to 167 knees that received a modified Ranawat cocktail (MR group). Perioperative care pathways remained consistent during the study period, as were requirements for MUA which included flexion range of motion below approximately 90 at 6–12 weeks. To compare the incidence of MUA between the groups, a population-averaged Poisson regression analysis was used. Results: The two groups were similar, with mean age of 63 (range 31–91) in the LB group and 64 (range 42–84) in the MR group, a preponderance of females in both groups ( p = 0.866), similar preoperative knee flexion between groups ( p = 0.162), and similar Patient-Reported Outcomes Measurement Information System scores. The frequency of MUA, however, was significantly lower in the MR group (LB: 7.7% [95% CI 3.7–12%] vs. MR: 2.4% [95% CI <1–4.7%] [IRR 3.2, 95% CI 1.08–9.76, p . 0.037]). Conclusions: In summary, this is a novel report of a potentially previously unrecognized increased incidence of MUA associated with the use of LB compared with a MR cocktail. Given no other notable changes to the perioperative care or MUA thresholds following TKA, the reasons for these findings are unclear but deserve additional investigation.
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Thanh, Lê Thị Tuyết. "Nguồn thông tin, lòng tin và sự lựa chọn nơi mua rau: Nghiên cứu ở Thành phố Hồ Chí Minh." KINH TẾ VÀ QUẢN TRỊ KINH DOANH 13, no. 1 (June 7, 2020): 202–18. http://dx.doi.org/10.46223/hcmcoujs.econ.vi.13.1.1616.2018.
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Sau một thời gian dài không thay đổi trong thói quen chọn nơi mua rau hay thực phẩm nói chung, người tiêu dùng Thành phố Hồ Chí Minh (TP.HCM) thời gian gần đây đã bắt đầu dịch chuyển mạnh mẽ từ các kênh truyền thống sang các kênh hiện đại như siêu thị hay siêu thị mini. Một trong các nguyên nhân thay đổi là vấn đề thực phẩm bẩn mà cụ thể là rau tại các kênh phân phối truyền thống không đảm bảo an toàn vệ sinh thực phẩm. Nghiên cứu này phân tích tác động của (1) lòng tin đối với người bán và quản lý nhà nước về VSATTP và (2) kênh tìm kiếm thông tin về VSATTP đến tần suất mua rau tại các kênh bán lẻ. Số liệu tự điều tra từ 254 người mua rau tại TP.HCM được phân tích bằng mô hình Seemingly Unrelated Negative Binomial. Kết quả nghiên cứu cho thấy những người tin ở chính sách quản lý VSATTP có xu hướng chọn mua rau ở chợ nhiều hơn và do đó cải thiện chính sách quản lý an toàn thực phẩm đối với rau sẽ giúp cải thiện hoạt động của chợ truyền thống. Ngoài ra những người tìm hiểu thông tin qua truyền thanh truyền hình và báo chí có tần suất mua rau ở siêu thị cao. Cửa hàng RAT có thể nhờ kênh truyền miệng để tăng lượng khách hàng vì những người tìm hiểu thông tin qua kênh truyền miệng có xu hướng mua rau ở cửa hàng RAT nhiều hơn.
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Chen, Y., S. Chen, and Y. Lei. "Surface Structure and Anti-Corrosion Properties of Copper Treated by a Dopamine-Assisted 11-Mercaptoundecanoic Acid Film." Corrosion 68, no. 8 (June 1, 2012): 747–53. http://dx.doi.org/10.5006/0462.
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An 11-mercaptoundecanoic acid (MUA) film was successfully prepared on the dopamine-modified copper substrates with good adhesive force and corrosion resistance. The formation and surface structure of the film were characterized by water contact angle measurement, scanning electron microscopy (SEM), and x-ray photoelectron spectroscopy (XPS). The inhibition behavior of the complex film was investigated using Tafel polarization curves and electrochemical impedance spectroscopy (EIS) in 3.5 wt% sodium chloride (NaCl) solution. The electrochemical results show that the poly(dopamine)/MUA complex film improves greatly the corrosion resistance and interfacial adhesive force on copper substrate. The inhibition efficiency of the poly(dopamine)/MUA complex film increases to 97.7%.
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Catapano, Santo, Mattia Ferrari, Nicola Mobilio, Marco Montanari, Massimo Corsalini, and Francesco Grande. "Comparative Analysis of the Stability of Prosthetic Screws under Cyclic Loading in Implant Prosthodontics: An In Vitro Study." Applied Sciences 11, no. 2 (January 11, 2021): 622. http://dx.doi.org/10.3390/app11020622.
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Background: To compare the loss of preload in absence of loading and after a fixed number of cyclic loadings on 7-mm distal cantilever in two different connection systems using all-on-four prosthetic model. Methods: Two equal models of an edentulous mandible rehabilitated with all-on-four technique with two types of abutment system (MUA and OT-Bridge) supporting a hybrid prosthesis, were used. Initial torque values of the prosthetic fixing screw, after ten minutes from initial screw tightening and after 400,000 repeated loadings were registered using a mechanical torque gauge. Differences between initial and final torque values were reported for each anchoring system and the two systems were finally compared. Results: No statistically significant differences regarding the loss of preload between MUA and OT-Bridge system were found after 400,000 cyclic loadings; however, in MUA system it was found between anterior and posterior implant screws. A significant difference in preload loss was found only for MUA system comparing the initial screw torque to that measured after 10 min from the tightening in absence of cyclic loadings. Conclusions: Within the limits of the present study, MUA and OT-Bridge may be considered reliable prosthetic anchoring systems able to tolerate repeated cyclic occlusal loads on distal cantilever in all-on-four rehabilitation model without any significant loss of preload in screw tightening.
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Catapano, Santo, Mattia Ferrari, Nicola Mobilio, Marco Montanari, Massimo Corsalini, and Francesco Grande. "Comparative Analysis of the Stability of Prosthetic Screws under Cyclic Loading in Implant Prosthodontics: An In Vitro Study." Applied Sciences 11, no. 2 (January 11, 2021): 622. http://dx.doi.org/10.3390/app11020622.
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Background: To compare the loss of preload in absence of loading and after a fixed number of cyclic loadings on 7-mm distal cantilever in two different connection systems using all-on-four prosthetic model. Methods: Two equal models of an edentulous mandible rehabilitated with all-on-four technique with two types of abutment system (MUA and OT-Bridge) supporting a hybrid prosthesis, were used. Initial torque values of the prosthetic fixing screw, after ten minutes from initial screw tightening and after 400,000 repeated loadings were registered using a mechanical torque gauge. Differences between initial and final torque values were reported for each anchoring system and the two systems were finally compared. Results: No statistically significant differences regarding the loss of preload between MUA and OT-Bridge system were found after 400,000 cyclic loadings; however, in MUA system it was found between anterior and posterior implant screws. A significant difference in preload loss was found only for MUA system comparing the initial screw torque to that measured after 10 min from the tightening in absence of cyclic loadings. Conclusions: Within the limits of the present study, MUA and OT-Bridge may be considered reliable prosthetic anchoring systems able to tolerate repeated cyclic occlusal loads on distal cantilever in all-on-four rehabilitation model without any significant loss of preload in screw tightening.
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Tú, Huỳnh Thanh, and Trần Văn Tuấn. "Các yếu tố ảnh hưởng đến ý định mua lặp lại sản phẩm trị nám của phụ nữ tại Thành phố Hồ Chí Minh." TẠP CHÍ KHOA HỌC ĐẠI HỌC MỞ THÀNH PHỐ HỒ CHÍ MINH - KINH TẾ VÀ QUẢN TRỊ KINH DOANH 16, no. 2 (May 29, 2021): 17–29. http://dx.doi.org/10.46223/hcmcoujs.econ.vi.16.2.1323.2021.
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Nghiên cứu các yếu tố ảnh hưởng đến ý định mua lặp lại sản phẩm trị nám của phụ nữ tại Thành phố Hồ Chí Minh từ đó đưa ra các đề xuất hàm ý quản trị giúp cho khách hàng của các công ty nâng cao ý định mua lặp lại sản phẩm trị nám tại Thành phố Hồ Chí Minh. Quá trình nghiên cứu đã khảo sát 370 người tại các cửa hàng mỹ phẩm và đã chọn lọc ra được 354 người có phiếu trả lời hợp lệ. Kết quả nghiên cứu đã phát hiện 05 yếu tố ảnh hưởng tới ý định mua lặp lại sản phẩm trị nám của phụ nữ tại Thành phố Hồ Chí Minh, đó là: Người nổi tiếng (X1), Giá sản phẩm (X2), Bao bì sản phẩm (X4), Chất lượng sản phẩm (X5), Độ tuổi (X6). Trong đó, X2 (β=0.281), X6 (β=.192) là hai yếu tố tác động mạnh nhất tới ý định mua lặp lại sản phẩm trị nám của phụ nữ tại Thành phố Hồ Chí Minh. Kết quả nghiên cứu đã gợi ý một số hàm ý quản trị quan trọng cho các công ty nhằm nâng cao ý định mua lặp lại sản phẩm trị nám của phụ nữ tại Thành phố Hồ Chí Minh.
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Heyne, Benjamin, Kristin Arlt, André Geßner, Alexander F. Richter, Markus Döblinger, Jochen Feldmann, Andreas Taubert, and Armin Wedel. "Mixed Mercaptocarboxylic Acid Shells Provide Stable Dispersions of InPZnS/ZnSe/ZnS Multishell Quantum Dots in Aqueous Media." Nanomaterials 10, no. 9 (September 17, 2020): 1858. http://dx.doi.org/10.3390/nano10091858.
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Highly luminescent indium phosphide zinc sulfide (InPZnS) quantum dots (QDs), with zinc selenide/zinc sulfide (ZnSe/ZnS) shells, were synthesized. The QDs were modified via a post-synthetic ligand exchange reaction with 3-mercaptopropionic acid (MPA) and 11-mercaptoundecanoic acid (MUA) in different MPA:MUA ratios, making this study the first investigation into the effects of mixed ligand shells on InPZnS QDs. Moreover, this article also describes an optimized method for the correlation of the QD size vs. optical absorption of the QDs. Upon ligand exchange, the QDs can be dispersed in water. Longer ligands (MUA) provide more stable dispersions than short-chain ligands. Thicker ZnSe/ZnS shells provide a better photoluminescence quantum yield (PLQY) and higher emission stability upon ligand exchange. Both the ligand exchange and the optical properties are highly reproducible between different QD batches. Before dialysis, QDs with a ZnS shell thickness of ~4.9 monolayers (ML), stabilized with a mixed MPA:MUA (mixing ratio of 1:10), showed the highest PLQY, at ~45%. After dialysis, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with a mixed MPA:MUA and a ratio of 1:10 and 1:100, showed the highest PLQYs, of ~41%. The dispersions were stable up to 44 days at ambient conditions and in the dark. After 44 days, QDs with a ZnS shell thickness of ~4.9 ML, stabilized with only MUA, showed the highest PLQY, of ~34%.
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Jandhyam, Harithalakshmi, and Subas Chandra Parija. "Vasorelaxation Caused by Eugenol, Curcumin and Nanocurcumin is Partially Mediated by Activation of Aminoguanidine-sensitive iNOS in the Middle Uterine Artery of Non-pregnant and Pregnant Capra hircus." Natural Product Communications 13, no. 10 (October 2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301025.
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Natural products like eugenol and curcumin have been reported to control hypertension. The purpose of our study was to examine the role of iNOS in eugenol/curcumin/nanocurcumin–induced vasorelaxation in the middle uterine artery (MUA) obtained from non-pregnant (NP) and pregnant (P) Capra hircus ( Ch). The MUA rings were mounted in an automatic organ bath attached to a powerlab data acquisition system. Vasorelaxation was induced by eugenol/curcumin/nanocurcumin in either the absence or presence of aminoguanidine in phenylephrine precontracted MUA rings. The vasorelaxation response was recorded isometrically by a highly sensitive isometric force transducer automatic organ bath connected to powerlab and analysed using Labchart 7.1.3 software. The maximal vasorelaxation (Rmax) obtained from eugenol, curcumin and nanocurcumin -induced concentration related contractile response elicited in PE- precontracted ED+ MUA rings was 49.5%, 42.6%, and 40.4% in NP, and 79.5%, 55.5%, and 44.1% in P Ch. Aminoguanidine attenuated the Rmax of eugenol, curcumin and nanocurcumin to 28.2%, 28.5%, and 16.4% in MUA of NP, and 57.2%, 57.4%, and 38.0% in MUA of P Ch, respectively. The results demonstrated that vasorelaxation to (i) Eugenol is partly mediated by partial activation of aminoguanidine-sensitive iNOS in the uterine artery and this pathway is augmented in pregnancy, (ii) Nanocurcumin is mediated by activation of aminoguanidine-sensitive iNOS in the uterine artery of NP, but not in P Ch and (iii) Curcumin is mediated by minimal activation of aminoguanidine sensitive iNOS only in the uterine artery of NP, but not in P Ch. In conclusion, eugenol and nanocurcumin possess a greater potential than curcumin in the control of hypertension due to partial activation of iNOS. These nutraceuticals could be useful to improve blood flow to the uterus to maintain oestrus cycle, maternal and fetal health.
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Hương, Trần Thị. "Một số yếu tố tác động đến quyết định chọn mua mặt hàng trang trí nội thất phòng khách của khách hàng tại Tp. HCM." TẠP CHÍ KHOA HỌC ĐẠI HỌC MỞ THÀNH PHỐ HỒ CHÍ MINH - KINH TẾ VÀ QUẢN TRỊ KINH DOANH 16, no. 2 (May 29, 2021): 193–206. http://dx.doi.org/10.46223/hcmcoujs.econ.vi.16.2.982.2021.
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Nghiên cứu này xem xét ảnh hưởng của các yếu tố tác động đến quyết định chọn mua mặt hàng trang trí nội thất phòng khách của khách hàng tại TP. HCM. Mô hình nghiên cứu được kiểm định với 275 khách hàng mua mặt hàng trang trí nội thất phòng khách tại địa bàn TP. HCM. Phương pháp phân tích Cronbach’s Alpha, phân tích EFA và hồi quy được dùng để xác định các yếu tố tác động chính đến quyết định mua mặt hàng trang trí nội thất. Kết quả kiểm định cho thấy ba yếu tố chính tác động đến quyết định mua hàng trang trí nội thất phòng khách là: (1) Sự cần thiết trang trí nội thất phòng khách; (2) Yếu tố giá cả và (3) Yếu tố chất liệu của mặt hàng trang trí nội thất phòng khách. Cuối cùng nghiên cứu đã đưa ra những khuyến nghị cho các doanh nghiệp, đơn vị kinh doanh mặt hàng trang trí nội thất.
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Liu, Kai, Xiangyu Li, Zhihui Zhu, Lodewijk Brand, and Hua Wang. "Factor-Bounded Nonnegative Matrix Factorization." ACM Transactions on Knowledge Discovery from Data 15, no. 6 (May 19, 2021): 1–18. http://dx.doi.org/10.1145/3451395.
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Nonnegative Matrix Factorization (NMF) is broadly used to determine class membership in a variety of clustering applications. From movie recommendations and image clustering to visual feature extractions, NMF has applications to solve a large number of knowledge discovery and data mining problems. Traditional optimization methods, such as the Multiplicative Updating Algorithm (MUA), solves the NMF problem by utilizing an auxiliary function to ensure that the objective monotonically decreases. Although the objective in MUA converges, there exists no proof to show that the learned matrix factors converge as well. Without this rigorous analysis, the clustering performance and stability of the NMF algorithms cannot be guaranteed. To address this knowledge gap, in this article, we study the factor-bounded NMF problem and provide a solution algorithm with proven convergence by rigorous mathematical analysis, which ensures that both the objective and matrix factors converge. In addition, we show the relationship between MUA and our solution followed by an analysis of the convergence of MUA. Experiments on both toy data and real-world datasets validate the correctness of our proposed method and its utility as an effective clustering algorithm.
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AuYong, Nicholas, Karen Ollivier-Lanvin, and Michel A. Lemay. "Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats." Journal of Neurophysiology 106, no. 4 (October 2011): 1943–53. http://dx.doi.org/10.1152/jn.00258.2011.
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The lumbar spinal cord circuitry can autonomously generate locomotion, but it remains to be determined which types of neurons constitute the locomotor generator and how their population activity is organized spatially in the mammalian spinal cord. In this study, we investigated the spatiotemporal dynamics of the spinal interneuronal population activity in the intermediate zone of the adult mammalian cord. Segmental interneuronal population activity was examined via multiunit activity (MUA) during air-stepping initiated by perineal stimulation in subchronic spinal cats. In contrast to single-unit activity, MUA provides a continuous measure of neuronal activity within a ∼100-μm volume around the recording electrode. MUA was recorded during air-stepping, along with hindlimb muscle activity, from segments L3 to L7 with two multichannel electrode arrays placed into the left and right hemicord intermediate zones (lamina V–VII). The phasic modulation and spatial organization of MUA dynamics were examined in relation to the locomotor cycle. Our results show that segmental population activity is modulated with respect to the ipsilateral step cycle during air-stepping, with maximal activity occurring near the ipsilateral swing to stance transition period. The phase difference between the population activity within the left and right hemicords was also found to correlate to the left-right alternation of the step cycle. Furthermore, examination of MUA throughout the rostrocaudal extent showed no differences in population dynamics between segmental levels, suggesting that the spinal interneurons targeted in this study may operate as part of a distributed “clock” mechanism rather than a rostrocaudal oscillation as seen with motoneuronal activity.