Dissertations / Theses: 'Mucdhl'

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Beck, Marine. "Implication et mode d'action de la cadhérine atypique MUCDHL dans la tumorigenèse intestinale." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ033.

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L’altération des mécanismes impliqués dans l’homéostasie intestinale peut conduire au développement de cancers colorectaux (CCR). Les CCR se situent au 2nd rang des décès par cancer en France et il est donc nécessaire d’améliorer nos connaissances pour mieux les soigner. L’objectif de ces travaux était de comprendre les mécanismes impliqués dans l’homéostasie intestinale par le biais de la Cadhérine atypique MUCDHL dont l’expression semble diminuée dans les CCR. Les conséquences de cette perte et le mode d’action de MUCDHL restent mal connus. Ainsi, l’étude d’une large cohorte de patients et d’un modèle murin a permis de confirmer que la perte de MUCDHL aggrave la tumorigenèse intestinale. De plus, la caractérisation de l’interaction entre MUCDHL et la β-caténine a montré que le mode d’action de MUCDHL est plus complexe qu’une simple séquestration membranaire de la β-caténine impliquant différentes voies de signalisation. Enfin ces travaux ont permis d’identifier des interactants de MUCDHL. Les résultats montrent pour la première fois le rôle de suppresseur de tumeurs de MUCDHL dans le côlon et apportent des informations sur sa régulation et son mode d’action
The alteration of mechanisms involved in intestinal homeostasis leads to the development of colorectal cancer (CRC). In France, CRC is the second leading cause of cancer mortality, and it is therefore necessary to improve our knowledge to treat it better. The objective of this project was to understand more precisely mechanisms involved in intestinal homeostasis through the atypical Cadherin MUCDHL whose expression seems decreased in CRC. However, the consequences of this loss, as well as the mode of action and the molecular relays of MUCDHL were largely unknown. Thus, the study of a large cohort of patients and of a murine model confirmed that the loss of MUCDHL enhances intestinal tumorigenesis. In addition, the functional characterization of the interaction between MUCDHL and β-catenin showed that the mode of action of MUCDHL is more complex than a simple membrane sequestration of β-catenin involving different signaling pathways. Finally, new interactants of MUCDHL were identified. The results obtained through this work show, for the first time, the tumor suppressor role of MUCDHL in the colon, and provide informations about its regulation and mode of action

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Baranger, Mathilde. "Implication et mode d'action de la cadhérine atypique Mucdhl dans la physiopathologie intestinale." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ048.

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Par sa fréquence et sa gravité, le cancer colorectal (CCR) demeure un problème de santé publique. Notre objectif global est de mieux comprendre les mécanismes impliqués dans l'homéostasie intestinale au travers de Mucdhl, une cadhérine atypique méconnue mais qui semble jouer un rôle très particulier dans l'épithélium intestinal et être impliquée dans les CCR. De manière intéressante, son expression semble fréquemment perdue dans les CCR, tandis que son maintien dans les cellules cancéreuses coliques diminue leur potentiel tumoral.Pour mieux appréhender le mode d'action de Mucdhl, une caractérisation fonctionnelle de son interaction avec β-caténine oncogénique a été réalisée et de nouveaux partenaires ont été identifiés dans les cellules intestinales. Afin de comprendre le rôle de Mucdhl dans la physiologie intestinale, encore inconnu à ce jour, un modèle murin déficient pour Mucdhl a été étudié. L'analyse des conséquences de la perte d'expression de Mucdhl indique qu'il est impliqué dans la structure et le fonctionnement de l'intestin chez la souris, mais également au niveau de processus métaboliques. De plus, cette perte d'expression de Mucdhl augmente la sensibilité des souris au développement de certaines tumeurs intestinales. Ces travaux ont donc permis de générer des informations inédites sur les fonctions physiopathologiques de Mucdhl, une cadhérine atypique encore mal connue, mais potentiellement impliquée dans les CCR
Because of its frequency and severity, Colorectal Cancer (CRC) remains an important public health issue. Our objective is to understand mechanisms contributing to intestinal homeostasis through Mucdhl, a poorly characterized atypical cadherin that may play a unusual role in the intestinal , epithelium and be implicated in CRC. lnterestingly, its expression seems to be frequently reduced in CRC, while its retention in colon cancer cells decreases their tumorigenic potential.To better apprehend the mode of action of Mucdhl, a functional characterization of its interaction with oncogen,iç β-catenin was performed and new partners have been identified in intestinal cells.To understand the role of Mucdhl in intestinal physiology, mice genetically-invalidated at the Mucdhl locus were studied. Analysis of the consequences of Mucdhl loss of expression indicates that it is involved in the morphology and function of the mouse intestine, but also in metabolic processes. Moreover, Mucdhl loss of expression increases the sensibility of mice to the development of certain intestinal tumors. Thus, we generated new information on the physiopathological functions of Mucdhl, an intriguing atypical cadherin potentially involved in CRC

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Moufok-Sadoun, Ahlam. "Rôle de la cadhérine atypique MUCDHL dans le système digestif et ses pathologies." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ075/document.

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MUCDHL est une cadhérine atypique encore peu étudiée. Les données obtenues à ce jour suggèrent que ce gène joue un rôle suppresseur de tumeurs dans l’intestin, notamment par son interaction et son effet inhibiteur sur la β-caténine, et que son expression est fréquemment diminuée dans les cancers colorectaux (CCR). Parallèlement à cette fonction anti-oncogénique, d’autres travaux ont suggéré que MUCDHL est impliquée dans la structuration de la bordure en brosse (BB) intestinale, en contribuant à la formation d’un complexe d’interaction inter-microvillositaire. Notre objectif était de déterminer la fonction et le mode d’action de MUCDHL dans le système digestif. Par la caractérisation détaillée de l’interaction avec la β-caténine, nous avons montré que le mode d’action anti-oncogénique de MUCDHL est plus complexe qu’une simple séquestration membranaire de la β-caténine. De plus, nous avons confirmé le rôle suppresseur de tumeurs de MUCDHL sur une cohorte importante de CCR humains et montré pour la première fois que sa perte amplifie la tumorigenèse intestinale dans un model murin. Par ailleurs, l’étude phénotypique des souris Mucdhl-/- a démontré son importance dans l’homéostasie du système digestif. En effet, l’absence de MUCDHL cause des altérations morphologiques de la BB intestinale, mais également de nombreuses perturbations métaboliques. Ces travaux apportent donc des informations inédites sur la fonction et le mode d’action de MUCDHL dans le système digestif
MUCDHL is an atypical cadherin that has been poorly studied. The data obtained so far suggest that this gene has tumor suppressive activity in the intestine, namely by its interaction and inhibitory effect on β-catenin, and that its expression is frequently decreased in colorectal cancers (CCR). In parallel to this anti-oncogenic function, other studies have suggested that MUCDHL is involved in the assembly of the intestinal brush border (BB), by contributing to the formation of an inter-microvilli interaction complex. Our objective was to determine the function and mode of action of MUCDHL in the digestive system, Through a detailed characterization of the interaction with β-catenin, we showed that the anti-oncogenic mode of action of MUCDHL is more complex than a simple membrane sequestration of β-catenin. In addition, we confirmed the tumor suppressive function of MUCDHL on a very large cohort of human CCR and showed for the first time that its loss amplifies intestinal tumorigenesis in a murine model. Moreover, the study of the phenotype of Mucdhl-/- mice allowed us to demonstrate the importance of MUCDHL in the homeostasis of the digestive system. Indeed, the absence of MUCDHL causes morphological alterations of the intestinal BB, but also numerous metabolic disturbances. Thus, this work provides new information on the function and mode of action of MUCDHL in the digestive system

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Bersuder, Émilie. "Cadhérine atypique MUCDHL et maladies inflammatoires chroniques intestinales : implication dans leur pathogénie, l'évolution cancéreuse et la réponse au traitement par les dérivés 5-aminosalicylés." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ026.

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Les causes des Maladies Inflammatoire Chroniques Intestinales (MICI) restent mal comprises et il n’existe aucun traitement curatif. L’une des complications possibles des MICI est l’augmentation du risque de cancer colorectal (CCR). La cadhérine atypique MUCDHL pourrait être impliquée dans les MICI. Nous avons étudié le rôle de MUCDHL dans la pathogénie des MICI, ainsi que les mécanismes moléculaires qui restaurent son expression. Nous avons montré que l’expression de MUCDHL est diminuée dans la muqueuse intestinale inflammatoire. De plus, les 5-aminosalicylés, utilisés pour traiter les MICI et prévenir le CCR associé, augmentent son expression en stimulant celle de PPAR-γ et de CDX2 ou en inhibant celle de la β-caténine. Chez les souris Mucdhl -/-, l’absence de MUCDHL accélère et amplifie l’inflammation colique induite par le Dextran Sulfate de Sodium et retarde la réparation muqueuse. Nos données montrent l’implication de MUCDHL dans la physiopathologie des MICI et suggèrent qu’il pourrait constituer une cible thérapeutique d’intérêt
The pathogenesis of Inflammatory Bowel Diseases (IBD) remains poorly understood and there is currently no curative treatment. In addition, patients with colonic IBD are at increased risk of colorectal cancer (CRC). The atypical cadherin MUCDHL could be involved in IBD. We studied the role of MUCDHL in the pathogenesis of IBD, as well as the molecular mechanisms that restore its expression. We have shown that MUCDHL expression is decreased in the inflammatory intestinal mucosa. In addition, 5-aminosalicylates, used to treat IBD and prevent associated CRC, increase its expression by stimulating PPAR-γ and CDX2 or by inhibiting β-catenin. In Mucdhl -/- mice, the absence of MUCDHL accelerates and amplifies colonic inflammation induced by Dextran Sodium Sulfate and delays mucosal repair. Our data show MUCDHL's involvement in the pathophysiology of IBD and suggest that it could be a therapeutic target of interest

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Hinkel, Isabelle. "Plasticité des cellules cancéreuses coliques : impact du facteur d'identité tissulaire Cdx2." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00871086.

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Le facteur de transcription homéotique Cdx2 est un suppresseur de tumeurs et son expression est réduite de manière hétérogène dans les tumeurs coliques. Or, le cancer colorectal demeure un problème de santé publique par sa fréquence et sa gravité. Au travers de 3 sous-projets, cette thèse visait à comprendre le mode d'action de Cdx2. Premièrement, la cadhérine Mucdhl a été identifiée et caractérisée en tant que nouvelle cible de Cdx2 : Mucdhl inhibe la croissance des cellules cancéreuses coliques et s'oppose à l'activité de la -caténine. Deuxièmement, un effet inattendu de Cdx2 sur le cytosquelette et la rigidité cellulaire a été montré. Ceci pourrait expliquer comment Cdx2 intervient dans l'organisation structurale des entérocytes ou la migration. En parallèle, une lignée cellulaire rapportrice de l'expression de Cdx2 a été créé qui, après validation, sera un outil précieux pour l'étude des mécanismes moléculaires qui conditionnent l'hétérogénéité tumorale. Par la mise en évidence de nouvelles fonctions et cibles de Cdx2, cette thèse permet de mieux appréhender son rôle physiologique et son action de suppresseur de tumeurs dans l'intestin.

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Schönfuß-Krause, Renate. "Werner Heinz Muche." Teamwork Schönfuß, 2020. https://slub.qucosa.de/id/qucosa%3A73730.

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Werner Heinz Muche, auch W. Heinz Muche, (* 08. August 1911 Radeberg, † 10. September 1987 Radeberg). Naturwissenschaftler, Forschungsreisender, Lepidopterologe, Entomologe, Zoologe, Autor, Lehrmittelhersteller, Unternehmer, Muche war ein bedeutender, international anerkannter Entomologe und Zoologe. Er hat sich autodidaktisch zu einer wissenschaftlichen Kapazität in der Fachwelt entwickelt, die besonders auf dem Gebiet der Insektenkunde wissenschaftlich Wertvolles schuf, da diese Wissenschaft bis Mitte des 20.Jahrhunderts noch in den Anfängen stand. Sein Spezialgebiet waren die Käferfamilien der Alleculidae und Blattwespenarten, wobei er viele neue Arten entdeckte. Seine Arbeiten prägten die Forschungswelt nachhaltig, seine Sammlungen gingen an das „Staatl. Museum für Tierkunde Dresden“ und an das „Naturkundemuseum der Humboldt-Universität Berlin“. Heinz Muche bereiste auf seinen Sammelreisen alle Kontinente, er verfasste über 170 Schriften, einige von ihm entdeckte Arten wurden nach ihm benannt. Forschungs- und Sammelreisen führten ihn u.a. nach Montenegro, Mazedonien, Bulgarien, Griechenland, Türkei, Anatolien, Syrien, Italien, Sizilien, Jugoslawien, Mongolei, Mittelasien, China, Kaukasus, Mandschurei, Botswana/Afrika, Queensland/Australien.

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Primel, Antoine. "Étude du comportement d'un mélange de fluide supercritique et de polyuréthane thermoplastique pour une application de pièces automobiles." Thesis, Lorient, 2015. http://www.theses.fr/2015LORIS378.

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L’objectif de cette thèse est d’étudier le comportement d’un mélange de fluide supercritique(diazote ou dioxyde de carbone) et de polyuréthane thermoplastique àl’état fondu lors de la mise en œuvre de butée d’attaques d’amortisseurs par le procédé d’injection Mucell®. Dans un premier temps, l’état de l’art a été développé dans une synthèse bibliographique qui a permis de décrire les principaux phénomènes intervenants lors de la transformation d’un mélange de fluide supercritique et de polymère en mousse micro-cellulaire. Puis, une étude à l’échelle laboratoire a permis de caractériser et de modéliser le comportement d’un polyuréthane thermoplastique mis en contact avec un fluide supercritique et de déduire les caractéristiques et les comportements essentiels à la compréhension des différents phénomènes rencontrés dans le procédé de mise en œuvre (diffusion, solubilité, nucléation...). Enfin, la dernière partie de ces travaux concerne la mise en application des connaissances précédemment acquise sur les moyens industriels dans le but de d’analyser et de stabiliser le moussage micro-cellulaire généré
The aim of this thesis is to study the behavior of a supercritical fluid (nitrogen or carbon dioxide) and thermoplastic polyurethanemeltmix during the production of jounce bumpers by the MuCell® injection molding process. First of all, the state of the art was developed in a literature review which allowed to describe the main phenomena that occur during processing of a mixture of supercritical fluid and polymer in microcellular foam. Then, a study at the laboratory scale allowed to characterize and model the behavior of a thermoplastic polyurethane in contact with a supercritical fluid and deduct the characteristics and behaviors essential to the understanding of various phenomena encountered during the process(diffusion, solubility , nucleation...). Finally, the last part of this work concerns the implementation of previously acquired knowledge on industrial means in order to analyze and stabilize the generated microcellular foam

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Muckel, Stefan [Verfasser]. "Kriterien des verfassungsrechtlichen Vertrauensschutzes bei Gesetzesänderungen. / Stefan Muckel." Berlin : Duncker & Humblot, 2019. http://d-nb.info/1238221440/34.

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Mello, Matheus Simões. "Hermanos Y cercanos, pero no mucho." reponame:Repositório Institucional da UFSC, 2015. https://repositorio.ufsc.br/xmlui/handle/123456789/157341.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Jornalismo, Florianópolis, 2015.
Made available in DSpace on 2015-12-29T03:04:18Z (GMT). No. of bitstreams: 1 336458.pdf: 1491337 bytes, checksum: 20378842e2fcd9c09054495ca7590e36 (MD5) Previous issue date: 2015
Esta pesquisa tem o propósito de observar semelhanças e diferenças entre o jornalismo esportivo brasileiro e argentino, com ênfase na tensão entre objetividade e subjetividade, tanto em relação ao texto publicado quanto às condições políticas, sociais e econômicas que influenciaram e influenciam o produto jornalístico esportivo dos dois países. Utiliza-se o estudo comparativo como principal procedimento metodológico, sendo executado por meio de dez itens de comparação, divididos em três categorias: construção textual, linguagem e discurso. Adota-se como corpus as matérias veiculadas nos jornais Lance! e Olé ? maiores diários esportivos nos seus respectivos países ? durante a Copa do Mundo de 2014, além de entrevistas semiestruturadas com jornalistas esportivos vinculados aos referidos veículos.

Abstract : This research proposed to observe similarities and differences between Argentinean and Brazilian sports journalism, emphasizing the tension between objectiveness and subjectiveness, not just inside of texts that had been published, but also the political, social and economical conditions that have been influencing the sports journalistic products in both countries. We utilized comparative study as main methodology procedure, using ten comparative topics, divided in three categories: textual construction, language and discourse. Wnalyzed articles from Lance! and Olé ? biggest sports newspapers into its nations ? during the 2014 Fifa World Cup, in addition to semi-structured interviews with sports journalists from the named journals.

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Suchánek, Matěj. "Vliv parametrů MuCell technologie na mechanické vlastnosti polymerů pro vstřikování." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-378395.

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This master’s thesis deals with influence of gas content in structure of polymer materials to mechanical properties. Test specimens were prepared by MuCell technology from polyphthalamide reinforced by 50 % of glass fiber content. The theorethical part of this thesis is focused on polymer materials with attention to polyamides and injection moulding technology. In the experimental part, the dependence between the characteristics obtained from the tensile test and the Charpy impact test on the amount of gas in the polymer is examined.

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Ousley, Christopher Allen 1969. "Open records in Arizona: How much information is too much?" Thesis, The University of Arizona, 1996. http://hdl.handle.net/10150/291957.

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This thesis examines conflicts concerning public access to government records. By examining the beginning, evolution and current state of public records access in America, and specifically in Arizona, this thesis explores the question, "How much access to personal information contained in government records is too much?" It is my thesis that American democracy cannot survive without open government records. Open government records, including voter records, educational records, motor vehicle records, property tax records and real estate records, allow citizens to keep informed concerning government matters and to oversee the conduct of government employees and elected officials. American democracy is based upon this oversight by citizens. Without public access to government records, the principles of democracy would be undermined and freedoms eroded. This thesis concludes that the citizen's right to know, though not a constitutional right, is a right that Americans must protect to ensure a strong democracy.

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Whalen, David. "Much Ado About Nothing: How Much Do The Oscars Matter?" Miami University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=miami1437752917.

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Askin, Trina. "That much poems /." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5060.

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DeHaven, Javan M. "So Much for Sensation." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1398418971.

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McBride, Emily. "so much apparent nothing." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4238.

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This document contains reflections on motivations behind selected works leading up to and including my thesis exhibition so much apparent nothing. Through journal excerpts and analysis of my own psychology, I attempt to put into words my thoughts concurrent to my making, indirect as they may be. The following text shares my personal conflicts and ideologies surrounding art-making, the permanence of objects, and the acceptance of an identity in flux.

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Bratcher, Beau. "Much Ado About Process: One Director's Approach to Shakespeare's Much Ado About Nothing." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1144.

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The following thesis is a brief view of production of UNO's Spring 2009 production of Shakespeare's classic comedy Much Ado About Nothing. This thesis will include analysis, research, production book, documentation from the production, and an evaluation of the process of bringing the production to life. The play was performed in New Orleans, Louisiana, at the University of New Orleans Performing Arts Center Robert E. Nims Theatre on April 23, 24, 25, and 30 as well as May 1, 2, and 3.

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Avotri, Joyce Yaa. ""Thinking too much" and "worrying too much" : Ghanaian women's accounts of their health problems /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ30068.pdf.

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Cloud, Dawn. "Eyes That Seen Too Much." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/english_theses/60.

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This thesis is compiled of four short stories and is an excerpt from a story cycle that I’ve been working on for the last four years entitled Eyes That Seen Too Much. These stories follow the challenges faced by the Labossierre women. Although most fiction writing does address challenges and/or how characters face their particular challenges, this story cycle is slightly different due to the unconventional backgrounds of the characters. Katherine and her sister Raquel grew up as Prostitutes in Louisiana, where their mother, Bit (Lil’ Bit) was also a Prostitute. The sister’s daughters, Kennedy and Marie become Exotic Dancers in adulthood, and the reader witnesses some of the challenges that they face as children and the social constraints of being daughters of former prostitutes and exotic dancers.

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Trujillo, Rachel. "To Whom Much Is Given." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/634.

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Editorial, Comité. "OPQ successes and much more. . ." Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/100591.

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Guidroz, Ashley Michelle. "How Much Diversity is Diversity?" Bowling Green State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1206122218.

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Halpern, Susan B. "So much larger than life." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1303316597.

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Camano, Javier. "Integrated Marketing Communications: Branding Plan for Medicare y Mucho Mas." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/472.

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The purpose of this paper is to explain the appropriate and effective use of branding as a vital part of the communication process of an organization. In addition, this project will help identify issues to improve enthusiasm for the use of the brand, help managers become aware of brand loyalty, and show how to measure the effectiveness of the brand.

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Dusza, Erin M. "Epic Significance: Placing Alphonse Mucha's Czech Art in the Context of Pan-Slavism and Czech Nationalism." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/art_design_theses/103.

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@font-face { font-family: "Cambria"; }p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0in 0in 0.0001pt; text-indent: 0.5in; line-height: 200%; font-size: 11pt; font-family: "Times New Roman"; }span.addmd { }div.Section1 { page: Section1; } Alphonse Mucha is primarily known for his early career producing Parisian Art Nouveau posters. However in 1910, Mucha left Paris to return to his home in the Czech lands where he concentrated on creating works for his country. Unfortunately, the later part of his career receives little to no attention in most art history books. His collection, The Slav Epic, represents ideas of Pan-Slavism, patriotism, and national identity. A leading scholar of national identity was Johann Gottfried Herder, a Czech sympathizer who influenced writers such as Jan Kollár and the historian František Palacký. Mucha’s works provided a visual representation of national identity and collective history specifically called for by these scholars. This thesis seeks to shed light on the late works of this artist, tracing the ever-present Slavonic influences, and also to place them in context within Czech Nationalism and Pan-Slavism in order to establish their historical significance.

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Hancock, Angela. "How much is too much? : exploring clinical recognition of excessive maternal blood loss during childbirth." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/how-much-is-too-much-exploring-clinical-recognition-of-excessive-maternal-blood-loss-during-childbirth(664934eb-a495-4895-b02b-e44e5cfc7295).html.

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Background: Postpartum haemorrhage (PPH) is the leading cause of maternal death worldwide. For every woman that dies, 20 or 30 more will experience morbidity. Severe PPH is increasing and is the leading cause of severe maternal morbidity in the UK. Rapid recognition of PPH is essential, but concealed bleeding, underestimation of blood loss and a failure to appreciate the physiological effects of blood loss, lead to delays in recognition and treatment. Experts believe that most deaths from PPH could be avoided by earlier diagnosis, but there is a lack of evidence on how to achieve this. Aims: To explore the experiences of those involved in evaluating blood loss during childbirth; and to develop and test a theory of blood loss evaluation and PPH recognition, as a prerequisite to developing strategies to support earlier diagnosis. Study Design: A sequential, exploratory mixed methods design was used. Methods: Qualitative methods included 8 focus groups and 19 one-to-one semi-structured interviews, conducted with 50 participants. These included: women and their birth partners (recruited from Liverpool Women's Hospital); and health professionals (midwives and obstetricians recruited from Saint Mary's Hospital, Manchester). A purposive sampling strategy was used to recruit women, who had experienced vaginal birth with or without PPH, and health professionals, with varying levels of experience in blood loss evaluation and PPH management. A snowball sampling strategy was used to recruit the birth partners of women participants. Phase one was completed from June to September 2014. All discussions were audio-recorded and transcribed verbatim. Data were managed using NVivo 10 qualitative data analysis software, which also supported the Framework approach to analysis and interpretation. Quantitative methods were used in phase two and involved 10 midwives and 11 obstetricians, recruited from Liverpool Women's Hospital, during February and March 2015. Two scenarios, one of fast and one of slow blood loss, were presented to the sample using clinical simulation with the NOELLEÂ® childbirth simulator, in a pilot, randomised, cross-over study. Participants also completed three questions about the use of the NOELLEÂ® mannequin for these types of scenarios. IBM SPSS Statistics version 23 software was used for quantitative data management and to estimate descriptive statistics. Numerical crossover data were copied into StatsDirect software, to perform the crossover analyses. Results: Women and birth partners were very perceptive to blood loss but felt ill-prepared for the reality of bleeding, with many experiencing negative emotional responses to both PPH and the lochia. Non-verbal communication from staff was used by women and their birth partners to interpret the seriousness of their blood loss. Health professionals: Recognition of PPH mainly occurs as an automatic response to the speed of blood flow. Volume of blood loss is often ascertained and used retrospectively after a PPH diagnosis, to validate the intuitive response and to guide and justify on-going decisions. This was confirmed by the simulation studies, where treatment was initiated at 100ml or less in all blood loss scenarios. Fast blood loss was more likely than slow blood loss to elicit a PPH response, despite volumes in the two groups being similar. Formal quantification of blood loss is not used routinely in practice. When it is used, values are often unofficially normalised to reflect health professionals' perceptions of the woman's clinical condition. Tools introduced to aid diagnosis, such as blood collection bags, routine weighing and the use of early warning scores, are not routinely used in the immediate post-birth period, especially if the woman and her blood loss are perceived to be normal. The tools are again used to validate intuitive feelings about blood loss and maternal condition. When they are used, the values are often modified if they contradict professional judgement. Conclusions: Women and birth partners want more information, open communication, and on-going support, to minimise the emotional impact of blood loss. For health professionals, the speed of blood loss is the crucial factor in PPH recognition rather than an accurate assessment of the volume of blood loss. The amount of visible blood is generally not initially interpreted as a volume, but is used to compare current blood losses to those previously witnessed. Experience therefore plays a crucial role in the decisions of whether blood loss is considered normal or excessive. Formal quantification of blood loss and regular recording of physiological observations do not occur routinely in the immediate post-birth period. Therefore, women with insidious blood loss can have delayed PPH diagnosis because they have a normal blood flow and exhibit minimal physiological changes, due to the compensatory mechanisms of shock. Often such women need to exhibit outward signs of physiological compromise, such as fainting or feeling unwell, before their physiological observations and blood loss are formally re-evaluated. Education of health professionals should highlight the common errors of judgement made during blood loss evaluation and provide feedback on cases of delayed recognition. Future research should examine normal postnatal bleeding in the hours following birth, and create visual aids for women to self-diagnose insidious blood loss. Training should focus on the skills of PPH recognition, particularly those with insidious blood loss and postnatal physiological assessments. Novel tools such as the shock index should be considered and evaluated as tools of assessment.

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Freemire, Ben. "High pressure gas filled RF cavity beam test at the Fermilab Mucool test area." Thesis, Illinois Institute of Technology, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3574935.

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With a new generation of lepton colliders being conceived, muons have been proposed as an alternative particle to electrons. Muons lose less energy to synchrotron radiation and a Muon Collider can provide luminosity within a smaller energy range than a comparable electron collider. This allows a circular collider to be built. As part of the accelerator, it would also be possible to allow the muons to decay to study neutrinos.

Because the muon is an unstable particle, a muon beam must be cooled and accelerated within a short amount of time. Muons are generated with a huge phase space, so radio frequency cavities placed in strong magnetic fields are required to bunch, focus, and accelerate the muons. Unfortunately, traditional vacuum RF cavities have been shown to break down in the magnetic fields necessary.

To successfully operate RF cavities in strong magnetic fields, the cavity can be filled with a high pressure gas in order to mitigate breakdown. The gas has the added benefit of providing cooling for the beam. The electron-ion plasma created in the cavity by the beam absorbs energy and degrades the accelerating electric field of the cavity. As electrons account for the majority of the energy loss in the cavity, their removal in a short time is highly desirable. The addition of an electronegative dopant gas can greatly decrease the lifetime of an electron in the cavity.

Measurements in pure hydrogen of the energy consumption of electrons in the cavity range in 10^-18 and 10^-16 joules per RF cycle per electron. When hydrogen doped with dry air is used, measurements of the power consumption indicate an energy loss range of 10^-20 to 10^-18 joules per RF cycle per ion, two orders of magnitude improvement over non-doped measurements. The lifetime of electrons in a mixture of hydrogen gas and dry air has been measured from < 1 ns, up to 200 ns. The results extrapolated to the parameters of a Neutrino Factory and Muon Collider indicate that a high pressure gas filled RF cavity will work in a cooling-channel for either machine.

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Mucha, Andreas [Verfasser]. "CMOS Integrated Impedance Sensor Arrays for Cell Adhesion Measurement / Andreas Mucha." Aachen : Shaker, 2013. http://d-nb.info/1051574897/34.

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Mucha, Claudia Magdalena Verfasser], and Dietmar [Akademischer Betreuer] [Zaefferer. "Theorie und Empirie des Phonästhems / Claudia Magdalena Mucha. Betreuer: Dietmar Zaefferer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1072038412/34.

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Pinto, Derrin Reese. "Perdóname,?llevas mucho esperando? : conventionalized language in L1 and L2 spanish /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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Nogueira, Ana Paula Gomes Dias. "Ilustração de moda segundo a obra de Mucha, Klimt e Schiele." Master's thesis, Universidade de Lisboa. Faculdade de Arquitetura, 2014. http://hdl.handle.net/10400.5/12111.

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Dissertação para obtenção do grau de Mestre em Design de Moda, apresentada na Universidade de Lisboa - Faculdade de Arquitectura.
A Ilustração de Moda foi, desde o seu aparecimento, considerada tanto um meio publicitário para as criações de designers, como um registo histórico do traje, tendo portanto passado por variadas técnicas, da pintura à fotografia, cobrindo também o desenho digital. Actualmente a Ilustração de Moda incluí o cruzamento de diferentes técnicas, criando assim um maior valor na peça final. Este Projecto de Investigação teórico-prático pretende chegar a um Estudo Exploratório do cruzamento da forma ilustrativa de grandes nomes da história da pintura com a Ilustração de Moda Contemporânea. Como casos de estudo, foram abordadas as obras de três pintores – Alphonse Mucha, Gustav Klimt e Egon Schiele –, e posteriormente utilizadas para ilustrar o trabalho de três designers de Moda Contemporânea – Givenchy, Balmain e Ann Demeulemeester. Partindo de uma procura e revisão de conhecimentos teóricos sobre a vida e obra dos artistas em estudo, pretende-se posteriormente reflectir estes conhecimentos na prática de experiências ilustrativas. A exploração prática desta Dissertação é dividida em três momentos, cada um resultando numa série de ilustrações distintas. No primeiro momento cada ilustração será realizada apenas com a influência da obra de um pintor; no segundo cada uma das ilustrações será baseada nas características da obra de dois pintores distintos; o terceiro e último momento resultará em ilustrações obtidas através do cruzamento das características formais dos três casos de estudo.
ABSTRACT: Fashion Illustration, since created, has been considered both an advertising medium for creations of design and an historical record of the costume, using several different techniques from painting to photography, including digital design. Currently Fashion Illustration encompasses the intersection of different techniques, creating a greater value in the final piece. This Theoretical Practical Research Project, aims to develop an exploratory study of the intersection of great names in the History of Painting, convened to the Illustration of Contemporary Fashion. As case studies, the formal work of three artists was addressed - Alphonse Much, Gustav Klimt and Egon Schiele -, and formerly used to illustrate the work of three contemporary fashion designers: Givenchy, Balmain and Ann Demeulemeester. The Project begins with the search and review of theoretical knowledge of the life and work of the artists under study, so that later, using this base, it is possible to reflect this knowledge in practice of illustrative experiences. The practical exploration of this Dissertation is organized in three moments, each resulting in a series of distinct illustrations. At first each illustration will be drawn under the influence of a painter only; in the second moment, each the illustration will be based on the characteristics of the work of two distinguished painters; while the third and final part, will result in a set of figures obtained by crossing the formal characteristics of the three case studies.

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Schönfuß-Krause, Renate. "Wenn/Wem die Welt zu eng wird ...: Bodo Christian Muche (* 8. Dezember 1939 in Radeberg): Künstlerbiografie eines Bildhauers und Bronzegießers in Australien." Teamwork Schönfuß, 2016. https://slub.qucosa.de/id/qucosa%3A73740.

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Bodo Muche (1939 Radeberg – 2017 Glenhowden/AU) Durch seinen wissenschaftlich engagierten Vater, den Entomologen Werner Heinz Muche, wurde bei ihm frühzeitig die Liebe zur Natur geweckt. Er nahm ihn mit zu gemeinsamen Erkundungen in der Heimat und förderte somit bei seinem Sohn die ein Leben lang anhaltende Faszination für die Schönheit jeglicher Lebewesen, die sich immer wieder in seinen späteren Bronzeplastiken widerspiegelte. Die Kleinstadt Radeberg wurde ihm beizeiten zu eng. In Berlin am Staatlichen Tierkundemuseum wurde er zum Präparator ausgebildet, weitere Studienrichtungen waren Zoologie, Anatomie, Kunstgeschichte und Design. 1958 verließ er die DDR, plante in der Schweiz seine wissenschaftliche Afrika-Reise, die ihn über Ostafrika und Tansania nach Betschuanaland (Botswana) führte. Über 17 Jahre arbeitete er in Studios in Tansania und Botswana, zunächst als Begleiter von Jagdsafaris und Präparator, später wandte er sich dem Naturschutz zu und der künstlerischen Gestaltung von Tierskulpturen, die er im Bronzegussverfahren/ Wachsausschmelzverfahren herstellte (Lost-wax casting). 1978 übersiedelte er mit seiner australischen Ehefrau Robyn nach Australien, gründete mit ihr in Glenhowden sein „Bodo Muche Foundry Studio“ und später ein zweites Studio in Los Angeles/USA. Er gehört weltweit mit zu den bekanntesten und gefragtesten Bronzegießern, der seine Skulpturen von „Minimal bis Maximal“ schuf, sogar berühmte Rennpferde in Lebensgröße für Auftraggeber in Sidney und den Oman.

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32

Murray, Andrew. "Too much power? : Unions or capital /." Title page, abstract and contents only, 1993. http://web4.library.adelaide.edu.au/theses/09AR/09arm981.pdf.

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Hadad, Filip. "How much value has building Visualization?" Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-124550.

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Denna studie beskriver hur byggvisualiseringen kan effektiviseras vid programskedet med en kombination av programvarorna Google Sketchup och Lumion. Studiens underlag har erhållits från ED bygger drömmar AB och beskrev ett bostadsområde som ska visualiserats. Syftet med studien är att ge förståelse för byggvisualiseringsprocessen samt att beskriva hur byggvisualiseringen kan effektiviseras vid programskedet. Studien består av två frågor som lyder: Hur går byggvisualiseringsprocessen till? Hur kan man effektivisera byggvisualiseringen vid programskedet? Metoden som användes för att svara på denna frågeställning är genom en beskrivning under hela experimentella byggvisualiseringsprocessen där resultatet kommer besvara på den nämnda frågeställningen. Arbetet genomfördes genom att data har samlats från den beskrivna byggvisualiseringsprocessen samt resultatet som byggvisualiseringen gav, där resultatet har beskrivits i en tabell samt renderade bilder. Slutsatsen som studien kom fram till var att avgörandet av effektiviseringen av visualiseringen är subjektiv och är beroende på läsaren. För att få ett klart svar så krävs det att läsaren själv gör sin bedömning angående sin egen situation.

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Demény, Bernadette. "Alphonse Mucha och art nouveau : En undersökning om influenser hos samtida illustratörer." Thesis, Södertörn University College, The School of Culture and Communication, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-1285.

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Arellano, García Roxana, Sánchez Luis Fernando Castellanos, Salazar Viviana de la Jara, Masías Karla Gaviño, Godinez Inés Martens, and López Margarita Valladares. ""Mucho ruido, pocas nueces" Sobre cómo nuestro sistema legal desincentiva el crédito." IUS ET VERITAS, 2017. http://repositorio.pucp.edu.pe/index/handle/123456789/123137.

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Fuhringer, Colleen Ann. "When more is more becomes too much." Thesis, Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/fuhringer/FuhringerC0512.pdf.

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Though we live in an age of uncertainty, we are constantly surrounded by what is predictable and routine. What happens when the comfort of our understanding is questioned? This body of work developed out of my experimental curiosity and desire to merge the familiar with the unexpected. Incorporating furniture and found objects brings a level of familiarity to the viewer, but manipulating the usual and adding strange elements causes inquiry. All of the components are set up into narrative tableaus and every part is considerably important to the whole. The installation explores humor and fear related to the grotesque and the uncanny, exploring contradictory elements such as: anthropomorphic and foreign, vibrant and static, seductive and repulsive. Each scene reveals no answers but poses only questions, inviting the viewer to fully experience their surroundings and come up with their own conclusions. We often exist between the margins of the known and the unknown but our understanding of this existence is purely individual.

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37

Rutz, Samuel. "International environmental agreements much ado about nothing? /." Aachen : Shaker, 2002. http://www.gbv.de/dms/zbw/359419127.pdf.

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38

Scheibehenne, Benjamin. "The effect of having too much choice." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2008. http://dx.doi.org/10.18452/15740.

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Die vorliegende Dissertation beschäftigt sich mit dem so genannten „Effekt zu großer Auswahl“. Der Effekt besagt, dass ein Überangebot von Auswahlalternativen negative Konsequenzen hat, in dem es beispielsweise die Motivation verringert, überhaupt eine Entscheidung zu treffen oder in dem es die subjektive Zufriedenheit mit der letztlich gewählten Alternative verringert. Die theoretischen Erklärung es Effektes sind jedoch bisher nur unzureichend präzisiert. Der Effekt steht im Widerspruch zu Axiomen der klassischen rationalen Entscheidungstheorie. Ein sicherer Nachweis des Effektes hätte daher Konsequenzen für die Theorienbildung in der Psychologie. Außerdem hätte der Effekt praktische Relevanz in angewandten Bereichen wie zum Beispiel im Konsumgütermarketing oder in der Politik. In der vorliegenden Arbeit wird zunächst der Versuch unternommen, bereits publizierte Studien zu replizieren, in denen große Effektstärken gefunden wurden. In einer Serie von insgesamt drei Replikationen mit insgesamt 850 Versuchsteilnehmern ließ sich jedoch der Effekt zu großer Auswahl nicht replizieren. Der Effekt scheint demnach weniger generalisierbar als bisher angenommen und sein Auftreten hängt vermutlich von spezifischen Randbedingungen ab. Die Arbeit widmet sich im weiteren der Frage wann, wieso und unter welchen Randbedingungen ein Effekt zu großer Auswahl zu erwarten ist. Dabei eine Reihe potenzieller Randbedingungen theoretisch begründet und in sechs weiteren Experimententen mit insgesamt 595 Teilnehmern getestet. Im Ergebnis können die meisten der getesteten Randbedingungen als Erklärung für das Auftreten des Effektes ausgeschlossen werden. Eine sich daran anschließende Meta-Analyse zeigt jedoch, dass der Unterschied zwischen Studien die einen Effekt nachweisen und solchen, in denen kein Effekt auftritt, vermutlich nicht allein durch Zufallsprozesse erklärbar ist. Demnach ist eine Suche nach weiteren Randbedingungen in zukünftiger Forschung gerechtfertigt.teste diese in sechs weiteren Experimententen mit insgesamt 595 Teilnehmern. Basierend auf den Ergebnissen dieser Experimente können die meisten der getesteten Randbedingungen als Erklärung für das Auftreten des Effektes ausgeschlossen werden. Die Ergebnisse einer sich daran anschließenden Meta-Analyse veröffentlichter und unveröffentlichter Daten zeigt jedoch, dass der Unterschied zwischen Studien die einen Effekt nachweisen und solchen, in denen kein Effekt auftritt, vermutlich nicht allein durch Zufallsprozesse erklärbar ist. Demnach ist eine Suche nach weiteren Randbedingungen in zukünftiger Forschung gerechtfertigt.
This dissertation explores the so-called too-much-choice effect, according to which an overabundance of options eventually leads to negative consequences, such as a diminished motivation to choose any of them or a decreased satisfaction with the finally chosen alternative. While strong instances of this effect have been found in a small number of studies in the past, its theoretical underpinnings are still unspecific. Because the effect challenges basic axioms of rational choice theory and it also has important implications for applied fields such as marketing and public policy making, it is important to get a better understanding of the mechanisms that lead to the effect. As a starting point to test these mechanisms, an experimental paradigm is needed in which the effect reliably occurs. Therefore, I first strived to replicate previous experiments that reported large effect sizes. Yet in a series of three replications in the field and in the lab with a total of 850 participants, I did not find an effect of too much choice, suggesting that the effect is less robust than previously thought and that it depends on certain boundary conditions instead. To find out which specific conditions are necessary to reliably elicit it, I subsequently examined several boundary conditions in a series of six laboratory experiments. Based on the results of these experiments with a total of 595 participants, most of the tested boundary conditions could be ruled out as explanations of why and when the effect of too much choice occurs. The results of a meta-analysis of published and unpublished data including my own suggest that the effect of too much choice is smaller than previously thought and that the differences between the studies that found the effect and those that did not cannot be explained by mere chance. As a consequence, a further search for moderator variables in future research seems justified.

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Whitlock, Lindsey C. "[There is So Much Blood in Us]." Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/scripps_theses/1145.

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[There is So Much Blood in Us] is an ambiguously alternate universe in which absolutely nothing is true but almost everything could be. In these poems, tension between the absurd and the possible synthesize into one linguistically and psychologically driving force – discomfort. More than anything, I am writing about discomfort. America’s media representations of women are almost always defined by a singular, and often sexualized experience. Yet, when I talk to the many wonderful / brilliant / badass / etc. women in my life, most of our truly defining experiences are impressively unsexy. Our womanity, if you will, orbits around the gravitational pulls of maternal relationships, vulnerability, and, yes – also periods. Thus, in these poems I place my anatomy into desexualized and uncomfortable moments, in order to emphasize my human corporeality over my sexual corporeality. With [There is So Much Blood in Us], I am challenging societal dehumanization of female bodies, and reminding America that our bodies are occupied.

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Muckel, Franziska [Verfasser], and Gerd [Akademischer Betreuer] Bacher. "Transition metal doped colloidal semiconductor nanocrystals : from functionality to device development / Franziska Muckel ; Betreuer: Gerd Bacher." Duisburg, 2018. http://d-nb.info/1155722787/34.

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Muckel, Franziska Elisabeth [Verfasser], and Gerd [Akademischer Betreuer] Bacher. "Transition metal doped colloidal semiconductor nanocrystals : from functionality to device development / Franziska Muckel ; Betreuer: Gerd Bacher." Duisburg, 2018. http://d-nb.info/1155722787/34.

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MacFadden, Peter B. "To whom much is given, much is required the rhetoric of privilege and responsibility at five elite American boarding schools /." [Bloomington, Ind.] : Indiana University, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3332474.

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Thesis (Ph.D.)--Indiana University, Dept. of Communication and Culture, 2008.
Title from PDF t.p. (viewed on May 14, 2009). Source: Dissertation Abstracts International, Volume: 69-09, Section: A, page: 3533. Adviser: Carolyn Calloway-Thomas.

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43

Rexer, Manuel, Nicolas Brötz, and Peter F. Pelz. "Much does not help much: 3D pareto front of safety, comfort and energy consumption for an active pneumatic suspension strut." Technische Universität Dresden, 2020. https://tud.qucosa.de/id/qucosa%3A71215.

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With regard to autonomous driving the demands on comfort are increasing. This makes it attractive to use active suspension systems. The system developed at TU Darmstadt is able to increase driving comfort up to 28 % while maintaining driving safety compared to a passive suspension system. This paper investigates the influence of available energy and power of the active system. The investigation is based on a simulation of a quarter car model and an uneven country road. This paper shows that the more energy the active system has at its disposition, the greater is the range between a comfortable and a sporty chassis. Furthermore the driving comfort can be increased by 28 % with constant driving safety. The average power required for this is 15 W and the maximum power is 300 W.

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44

Carter, Robert E. "Reciprocal Spillover Effects: Why, When, and How Much." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1178539472.

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Owen, Gregory L. "A Lighting Design Process For A Production Of William Shakespeare’s Much Ado About Nothing." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211984241.

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Colán, Mario. "Notas para una tripodología felina: Cuatro suyos, ninguno mío y mucho menos uno tuyo." Anthropía, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/78206.

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Schweizer, Karoline [Verfasser], Stefan [Gutachter] Muckel, and Daniela [Gutachter] Winkler. "Islamischer Religionsuntericht an öffentlichen Schulen nach dem Beiratsmodell in Nordrhein-Westfalen / Karoline Schweizer. Gutachter: Stefan Muckel ; Daniela Winkler." Köln : Universitäts- und Stadtbibliothek Köln, 2016. http://d-nb.info/1113178744/34.

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Engström, Höglund Maria. "So much more. Skriftlig del till konstnärligt examensarbete. Inspelningsprojekt." Thesis, Kungl. Musikhögskolan, Institutionen för jazz, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-1026.

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Hazleden, Rebecca Louise. "Women who read too much : relationship manuals and subjectivity." Thesis, University of Exeter, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403080.

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Gillam, Ron, and A. Lynn Williams. "How Much is Enough? Dosage in Child Language Intervention." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2059.

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This session is developed by the Convention Program Committee. Empirical evidence exists for many child language and phonological interventions; however, less is known about hteir optimal intensity. This seminar will provide an evidence-based review on what is known about session dose, duration and frequency, and total intervention duration. The practical implementation of evidence-based recommendations will be discussed.

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Dissertations / Theses on the topic 'Mucdhl'

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