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Relevant bibliographies by topics / Mucoprotective effect and Experimental rats

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Academic literature on the topic 'Mucoprotective effect and Experimental rats'

Author: Grafiati

Published: 3 June 2025

Last updated: 20 July 2025

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Journal articles on the topic "Mucoprotective effect and Experimental rats"

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Mehnoor, Farheen *. Rahmata Yasmeen *. Samreen Ayesha Sana Sara mizna Saleha sultana. "PHYTOCHEMICAL EVALUATION AND PHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACT OF AERIAL PARTS OF POLYGONUM GLABRUM FOR ANTIULCER ACTIVITY IN WISTAR RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 872–81. https://doi.org/10.5281/zenodo.1175794.

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Polygonum glabrum has been used to treat peptic ulcer disease , but its efficacy has not been validated. The present study was therefore carried out to evaluate the anti-ulcer activity of 75% ethanolic aerial extract of polygonum glabrum in wistar rats. The Antiulcer Activity of 75% ethanolic aqueous extract of aerial parts of Polygonum glabrum at a dose of 200, 400 mg/kg b.w p.o was investigated in Diclofenac induced ulcers in Albino Wistar rats (180-230 gm). In this model parameters evaluated are gastric volume, total acidity, free acidity and ulcer index. There was no mortality up to a dose of 2000 mg/kg b.w p.o indicating the safety of the plant. Preliminary Phytochemical studies showed the presence of Carbohydrates, Flavanoid, Glycosides, Tannins, Protein, Terpenes and Volatile Oils. 75% ethanolic aqueous extract of Polygonum glabrum at a dose of 200,400 mg/kg b.w p.o produced significant reduction of ulcers in diclofenac induced ulcer Model as compared to control group by decreasing gastric volume, total acidity, free acidity and severity of ulcer. The ulcer protective effect of extract was comparable with that of the standard drugs. Results of study suggest that 75% ethanolic aqueous extract of Polygonum glabrum posses Mucoprotective effect which may be due to the presence of flavanoids in the extract as it has an astringent property. Keywords: Antiulcer activity, Polygonum glabrum, Diclofenac, Mucoprotective effect and Experimental rats.

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Eutamene, Hélène, Catherine Beaufrand, Cherryl Harkat, and Vassilia Theodorou. "Effect of Two Mucoprotectants, Gelatin Tannate and Xyloglucan plus Gelatin, on Cholera Toxin-Induced Water Secretion in Rats." Gastrointestinal Disorders 4, no. 4 (2022): 324–32. http://dx.doi.org/10.3390/gidisord4040030.

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Background: Newer antidiarrheal agents include the mucoprotectants gelatin tannate and xyloglucan. Methods: Rat models of cholera toxin (CT)-induced water secretion were used to evaluate the mucoprotective effects of gelatin tannate, xyloglucan, and related compounds. Results: Oral pretreatment for 4 days with gelatin tannate (250 and 500 mg/kg/day), but not tannic acid or gelatin (both 125 mg/kg/day), blocked CT-induced intestinal water secretion. CT-induced intestinal water secretion was also attenuated by oral xyloglucan 12.5 mg/kg + gelatin 125 mg/kg (6 h pre-CT) and gelatin 250 mg/kg (12 h pre-CT), and by local (intra-jejunal loop) administration of gelatin, gelatin tannate and xyloglucan concomitantly with CT. Conclusions: Gelatin tannate and xyloglucan + gelatin attenuated CT-induced intra-loop water secretion in this experimental model, supporting previous evidence that their mechanisms of mucosal protection are closely related to their chemical structures, which confer film-forming properties via the formation of mucoadhesive films.

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Ko, Il-Gyu, Jun-Jang Jin, Lakkyong Hwang та ін. "Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats". European Journal of Pharmacology 874 (травень 2020): 172952. http://dx.doi.org/10.1016/j.ejphar.2020.172952.

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Kemeir. "HEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATS." American Journal of Animal and Veterinary Sciences 9, no. 1 (2014): 46–52. http://dx.doi.org/10.3844/ajavsp.2014.46.52.

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OKUNO, Takehiko, Yoshiyuki SEYAMA, and Saburo YAMASHITA. "Effect of Elastase on Experimental Atherosclerotic Rats." Journal of Japan Atherosclerosis Society 14, no. 3 (1986): 577–83. http://dx.doi.org/10.5551/jat1973.14.3_577.

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Kim, Chul Min, Jun Chul Park, In Soo Park, et al. "Effect of Reperfusion Experimental Myocardial Infarction in Rats." Korean Circulation Journal 18, no. 1 (1988): 57. http://dx.doi.org/10.4070/kcj.1988.18.1.57.

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Rosa-e-Silva, JC, GG Fortunato, JVC Zanardi, J. Meola, and AA Nogueira. "Effect of Cabergoline in Experimental Endometriosis in Rats." Journal of Minimally Invasive Gynecology 22, no. 6 (2015): S168. http://dx.doi.org/10.1016/j.jmig.2015.08.627.

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Sekar, Natesanpillai, Anumanthan Kanthasamy, Samuel William, Natarajan Balasubramaniyan, and Saminathan Govindasamy. "Antioxidant effect of vanadate on experimental diabetic rats." Acta Diabetologica Latina 27, no. 4 (1990): 285–93. http://dx.doi.org/10.1007/bf02580932.

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Jaiswal, Dolly, Prashant Kumar Rai, and Geeta Watal. "Antidiabetic effect of Withania coagulans in experimental rats." Indian Journal of Clinical Biochemistry 24, no. 1 (2009): 88–93. http://dx.doi.org/10.1007/s12291-009-0015-0.

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Srinivasan, K., K. Platel, and M. V. L. Rao. "Hypotriglyceridemic effect of dietary vanillin in experimental rats." European Food Research and Technology 228, no. 1 (2008): 103–8. http://dx.doi.org/10.1007/s00217-008-0911-1.

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Dissertations / Theses on the topic "Mucoprotective effect and Experimental rats"

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Ma, Qing-Yong. "Effect of L-arginine on an experimental model of colorectal cancer." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318725.

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Mingee, Catherine M. "The effect of hunger and effort on response variability in rats." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1333629053.

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Ferenchuk, Ye O. "Effect of glutathione on oxidative-antioxidant system in the liver of rats in experimental nephropathy." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19538.

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沈毅峰 and Ngai-fung Sham. "Study of the protective mechanisms of cigarette smoke and nicotine on experimental ulcerative colitis in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225081.

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Huumonen, S. (Sisko). "The effect of impaired dentin formation on dental caries:an experimental study in the molars of growing rats." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514252020.

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Abstract The effects of dietary sucrose and systemic glucocorticoid treatment on the response of the pulpodentinal complex to dental caries were examined in an experimental rat model. The possible role of dentinal caries on dentin formation was also examined. After 5-6 weeks of a dietary and/or medication period, the areas of dentin formation and dentinal caries were quantified in the molars of growing animals. Also the number and severity of caries lesions were estimated. The 43% sucrose diet significantly reduced dentin formation and increased dentinal caries progression. Although glucocorticoid medication alone reduced dentin formation, without dietary sucrose it did not have an effect on caries. In combination of these two, glucocorticoids further increased the progression of dentinal caries, however without significant increase in the number of caries lesions. The cariogenic bacterial inoculation of rats fed a sucrose or control diet increased the progression of dentinal caries. The relationship between cariogenic bacteria and caries was not strong, but there was a stronger relationship between the total amount of dietary sucrose and dentinal caries. In addition to the overall reduction of dentin formation there was no difference in the amount of dentin formed between intact and carious fissures in the sucrose diet group. On the contrary, rats receiving the control diet positively responded to the dentinal caries by increasing dentin formation to prevent pulpal exposure. Whereas the high sucrose diet impaired both the deposition and mineralization of the dentin matrix, glucocorticoids affected matrix formation only. These results indicate that the functional alterations in the pulpo-dentinal complex might contribute to dentinal caries progression in a cariogenic environment, irrespective of the causative mechanism.

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Schlundt, Jennifer Clare [Verfasser], and Wolfgang [Akademischer Betreuer] Herrmann. "Effect of Experimental Hyperhomocysteinemia on Brain Methylation and Neurodegenerative Markers in Rats / Jennifer Clare Schlundt. Betreuer: Wolfgang Herrmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051434408/34.

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O'Connor, Christine A. "The effects of oestrogen and progesterone on outcome following experimental traumatic brain injury in rats /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09pho186.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Pathology, 2004?<br>Includes list of articles published or accepted for publication during the period of PhD candidature. "July, 2004" Includes bibliographical references (leaves 255-293).

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Lima, Mariana dos Reis. "Effect of calendula officinalis in rats submitted to experimental periodontitis: participation of RANK-RANKL-OPG and WNT / Β-CATENIN PATHWAYS." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18394.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>Periodontitis is an infecto-inflammatory disease that leads to connective tissue and alveolar bone loss. Calendula officinalis (CLO) has been used due to its anti-inflammatory effects. Therefore the aim of this study was to evaluate the effect of CLO on alveolar bone loss (ABL) in rats focusing on RANK-RANKL-OPG and WNT signaling pathways. Experimental periodontitis (EP) was induced through placement of a nylon ligature around the upper left 2nd molar, and the hemimaxilla used as control. The animals were divided in groups: Normal, subjected to no treatment; Saline (SAL), that received 2 ml/kg of 0,9% saline solution orally; or CLO at 90 mg/kg orally, 30 minutes before EP and daily for 11 days until euthanasia. In order to evaluate the periodontal tissue, it macroscopic, micro-tomographic, electron scanning microscopy (SEM), confocal microscopy and polarized light microscopy analyses were performed, as well as immunohistochemistry for WNT 10b, β-catenin, DKK-1, RANK, RANKL, and OPG. During euthanasia the gingival tissue was removed for malonaldehyde (MDA) assay. Treatment with CLO significantly prevented ABL, preserved bone internal microstructure (p<0.05) and topography, and also preserved collagen fibers from the periodontal ligament, when compared to SAL. CLO significantly increased the number of immunopositive cells for WNT 10b, β-catenin and OPG and reduced DKK-1, RANK (p>0.05) and RANKL. CLO reduced the gingival levels of MDA compared to SAL (p<0.05). In this way, we can conclude that CLO prevented ABL via RANK-RANKL-OPG and WNT signaling pathway.<br>A periodontite Ã uma doenÃa infecto-inflamatÃria que causa perda de tecido conjuntivo e osso alveolar. A Calendula officinalis (CLO) tem sido utilizada pelos seus efeitos anti-inflamatÃrios. Nesse contexto, o objetivo deste trabalho foi avaliar efeito da CLO na perda Ãssea alveolar (POA) em ratos com foco na participaÃÃo do eixo RANK-RANKL-OPG e da via WNT/β-catenina. A periodontite experimental (PE) foi induzida atravÃs da inserÃÃo do fio (nailon 3.0) em torno do 2Â molar superior esquerdo, e hemiarcada contralateral usada como controle. Os animais foram divididos em grupos: Normal, nÃo submetido a nenhum procedimento; Salina (SAL), que receberam 2 ml/kg de soluÃÃo salina 0,9% - v.o.; ou CLO na dose de 90 mg/kg - v.o. 30 min antes da PE e diariamente durante por 11 dias atÃ eutanÃsia. Para avaliaÃÃo do tecido periodontal realizaram-se anÃlises macroscÃpica, por microtomografia computadorizada, por microscopia eletrÃnica de varredura (MEV), microscopia confocal e microscopia por luz polarizada, imunohistoquÃmica para WNT 10b, β-catenina, DKK-1, RANK, RANKL e OPG. Por ocasiÃo da eutanÃsia foi removido tecido gengival para avaliaÃÃo dos nÃveis de malondialdeÃdo (MDA). O tratamento com CLO preveniu de forma significante a POA, preservou a microestrutura interna (p<0,05) e topografia do tecido Ãsseo, e preservou tambÃm as fibras colÃgenas do ligamento periodontal, quando comparado a SAL. A CLO provocou aumento significante de cÃlulas imunopositivas para WNT 10b, β-catenina e OPG e reduÃÃo na imunomarcaÃÃo de DKK-1, RANK (p>0,05) e RANKL. CLO reduziu os nÃveis de MDA gengivais comparados a SAL (p<0,05). Desta forma, podemos concluir que a CLO previne a POA com participaÃÃo do eixo RANK-RANKL-OPG e da via WNT/β-catenina.

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Stepan, V. T. "Effect of oral phytogel «QUERTULIN» application in case of biochemical indicators of renal condition in rats with experimental dysbiotic syndrome." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18658.

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Eakin, Katharine Coryell. "The Effect and Chronic Acute Pre-Treatment with Methylphenidate on Recovery of Cognitive Function Following Experimental Traumatic Brain Injury In Rats." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/755.

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Adolescent and young adult males are at a higher risk for traumatic brain injury (TBI) compared to the general population. Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) is also more prevalent for males in these age groups. The most commonly prescribed medication for ADHD is methylphenidate (MPH). Based on the increase in the number of new diagnoses of ADHD and the number of children who continue taking MPH into adulthood, it is important to evaluate how chronic or acute MPH administered prior to injury may influence recovery following TBI. In both studies, cognitive abilities of male Sprague-Dawley rats were assessed on post-injury using the Morris Water Maze. There was no effect of chronic MPH treatment on cognitive outcome following TBI. In contrast, acute MPH pre-treatment improved cognitive outcome as measured by the MWM. The MPH + injury group reached sham-injury levels on days 4 and 5 in the MWM.

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Books on the topic "Mucoprotective effect and Experimental rats"

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1930-, Wu Bing-quan, and Zheng Jie, eds. Immune-deficient animals in experimental medicine. Karger, 1989.

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The effect of exercise on the presence of leukocytes, erythrocytes, and collagen fibers in rat skeletal muscle following experimental contusion. 1991.

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The effect of exercise on the presence of leukocytes, erythrocytes, and collagen fibers in rat skeletal muscle following experimental contusion. 1991.

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The effect of exercise on the presence of leukocytes, erythrocytes, and collagen fibers in rat skeletal muscle following experimental contusion. 1991.

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Book chapters on the topic "Mucoprotective effect and Experimental rats"

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Wu, Gaofeng, Jiancheng Yang, Changmian Sun, Xinhong Luan, Jiao Shi, and Jianmin Hu. "Effect of Taurine on Alcoholic Liver Disease in Rats." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-75681-3_32.

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Oikawa, Shigeru, Haruhisa Hirakawa, Tatsumi Kusakabe, and Yoshiaki Hayashida. "Effect of CO2 on Cardiovascular Regulation in Conscious Rats." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9280-2_60.

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Mochizuki, Hideki, Hiroaki Oda, and Hidehiko Yokogoshi. "Amplified Effect of Taurine on PCB-Induced Hypercholesterolemia in Rats." In Advances in Experimental Medicine and Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4899-0117-0_36.

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Cremer-Bartels, G., H. Gerding, L. Hanneken, and K. Krause. "Effect of Triamterene on the Electroretinogram of Long Evans Rats." In Advances in Experimental Medicine and Biology. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2960-6_71.

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Abdel-Salam, O. M. E., J. Szolcsányi, and Gy Mózsik. "The Effect of Resiniferatoxin on Experimental Gastric Ulcer in Rats." In Biochemical Pharmacology as an Approach to Gastrointestinal Disorders. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-011-5390-4_22.

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Sanada, T., L. H. Pitts, M. Nishimura, S. Byrd, and K. Isayama. "The Effect of Nimodipine Following Experimental Head Injury in Rats." In Nimodipine. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-48695-1_24.

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Liu, Ke Jian, P. Jack Hoopes, Ellis L. Rolett, et al. "Effect of Anesthesia on Cerebral Tissue Oxygen and Cardiopulmonary Parameters in Rats." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5865-1_5.

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Yan, Chong Chao, and Ryan J. Huxtable. "Effect of Taurine on Toxicity of the Pyrrolizidine Alkaloid Monocrotaline in Rats." In Advances in Experimental Medicine and Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0182-8_33.

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Hichri, Oubeidallah, Jean-C. Laurin, Cécile A. Julien, Vincent Joseph, and Aida Bairam. "Dose Dependent Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats." In Advances in Experimental Medicine and Biology. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4584-1_6.

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Kelleher, D. K., E. Baussmann, E. Friedrich, and P. Vaupel. "The Effect of Erythropoietin on Tumor Oxygenation in Normal and Anemic Rats." In Advances in Experimental Medicine and Biology. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2468-7_69.

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Conference papers on the topic "Mucoprotective effect and Experimental rats"

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"Effect of Finger Pressing on Anti-Inflammatory Effect in Obese Rats with Insulin Resistance." In 2020 International Clinical & Experimental Pharmacology and Oncology Forum. Association for Computer, Electronics and Education, 2020. http://dx.doi.org/10.48062/978-1-7773850-1-9.012.

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Glotova, I. V., I. Yu Ozerova, I. L. Privalova, and E. T. Kamal. "THE EFFECT OF EXPERIMENTAL ULCEROGENESIS ON THE CARDIAC ELECTRICAL ACTIVITY IN RATS." In MODERN PROBLEMS IN SYSTEMIC REGULATION OF PHYSIOLOGICAL FUNCTIONS. NPG Publishing, 2019. http://dx.doi.org/10.24108/5-2019-confnf-21.

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Almakaeva, D. S. "Effect of alcohol on cognitive functions of rats." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-11-4-8.

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The effect of alcohol on the cognitive abilities of laboratory rats was studied. Individuals systematically received small doses of alcohol for a long time (4 months). Throughout the study, the results of the cognitive functions of animals were recorded, namely the ability to navigate in space and motor activity. At 1 month of alcohol intake, the cognitive abilities of the studied individuals improved significantly, but by the end of the experiment, the experimental subjects showed significantly lower results, thereby revealing the negative effects of alcohol on the body.

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Jiang, W., L. Chen, H. Li, L. Min та Y. Wang. "INFLIXIMAB, A TNF-α INHIBITOR HAS PROTECTIVE EFFECT ON EXPERIMENTAL BENIGN ESOPHAGEAL STRICTURE IN RATS". У ESGE Days 2018 accepted abstracts. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1637439.

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Bernat, A., E. Vallée, J. P. Maffrand, and J. Gordon. "ROLE OF PLATELETS IN EXPERIMENTAL THROMBOSIS INDUCED BY VENOUS STASIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644498.

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Venous stasis in the rat, induced by ligature of the vena cava, provokes thrombosis. This venous thrombosis was initially believed to be platelet-independent because severe thrombocytopenia (95 % reduction in platelet count), aspirin and dipyridamole had little effect. However, the model responded to other platelet anti-aggregators, such as Ticlopidine and its analogue PCR 4099, although these compounds had no effect on coagulation, fibrinolysis or leucocyte functions (Thromb. Res. 37, 279-285, 1985). Both these drugs are known to exert their main antiplatelet effect against aggregation induced by ADP.The aim of the present study was to re-evaluate the role of platelets in this model of venous thrombosis. We have been able to show that :1) complete thrombocytopenia (99 %), achieved with an antiplatelet anti-serum, dramatically inhibited thrombus formation (by 84 % ; p < 0.01).2) partial transfusion of platelets (23 %) from control animals to these thrombocytopenic rats re-established the thrombosis.3) transfusion (under identical conditions) of platelets from rats treated with PCR 4099 had no effect.4) vena cava ligature in Fawn Hooded rats (deficient in platelet dense granules) induced less thrombosis (64 % of control ; p < 0.05).We conclude that this venous stasis model is platelet-dependent. Furthermore, because thrombus formation was reduced in normal rats treated with anti-aggregants acting selectively against ADP, and in rats lacking ADP in their platelet dense granules, it appears that ADP plays a major role in this model of thrombosis.

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Meneguzzo, Daiane T., Cristina Y. Okada, Márcia K. Koike, et al. "Effect of low intensity laser therapy in an experimental model of cranio-encephalic trauma in rats." In Biomedical Optics (BiOS) 2007, edited by Michael R. Hamblin, Ronald W. Waynant, and Juanita Anders. SPIE, 2007. http://dx.doi.org/10.1117/12.702252.

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Khan, Islam A., Asmaa A. Al-Failakawi, Aishah A. Al-Jarallah, and Muddanna A. Rao. "Altered expression of claudin proteins in experimental colitis induced in rats by dextransulphatesodium: Effect of nobiletin." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.143.128871.

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Opanike, Oyetunde, Olugbenga A. Omotosho, Emmanuel O. Akindele, and Omolola O. Yusuf. "Hepatocellular Effect of Copper Poisoning on the Liver and Kidney of Albino Rats (<i>Rattus norvicus</i>)." In 2023 International Conference on Sustainable Engineering and Materials Development. Trans Tech Publications Ltd, 2024. http://dx.doi.org/10.4028/p-vzg5cj.

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Copper and its salt are remarkably non-toxic to mammalian tissue. It is possible to ingest a large number of soluble copper salts such as copper sulphide to produce intoxication, nausea, vomiting, diarrhoea, and abdominal cramp. Copper salts are widely employed in agriculture and veterinary practice. Copper is an essential trace element in life and is a component of several metalloenzymes and other proteins such as cytochrome oxidase, heamocyanin, lysin oxidase, ascorbate oxidase and amine oxidase. When copper is present in the body above a particular dosage of greater than 100ppm in rats, it becomes fatal to rats. Copper is transported by blood, and is distributed to tissue and organs which have different retention capacities with the highest level of copper found in the liver, kidney, spleen and lungs. This study investigated the toxicological effect of copper in the liver and kidney of animals, using albino rats as the experimental animal. The serum chemistry report showed that the protein value of the liver homogenate for most of the experimental rats was higher than that of the control whereas the value of globulin for the control was similar to that of the experimental rats. The kidney homogenate revealed that Calcium ion has higher contents in the experimental rats than that in the control. In conclusion, the effect of copper varies with the groups of rats as compared to the control.

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Zhang, Boyin, Dongxu Zhao, and Chunyang Meng. "Experimental Research on the Effect of Ginsenoside Rb1 in Curing Rats with Spinal Cord Ischemia-reperfusion Injury." In International Conference on Biomedical and Biological Engineering. Atlantis Press, 2016. http://dx.doi.org/10.2991/bbe-16.2016.21.

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A Alsudani, Arjwan. "The Possible Protective Effect of Rutin to Reduce the Effect of Formaldehyde on Lung Tissue and Oxidative Stress in Rats." In IX. International Scientific Congress of Pure, Applied and Technological Sciences. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress9-15.

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This study aims to know the therapeutic role of one of the types of plant flavonoids (rutin) in reducing the negative effects resulting from inhalation of formaldehyde 40% and its effect on lung function and tissues of rats. As well as clarifying the effective role of rutin in enhancing the effectiveness of antioxidants and reducing the oxidation process, as rutin acts as a natural antioxidant and can be found in many plant species. In this investigation, a total of twenty-four white male rats were used, and these rats were randomly assigned to four groups, with six rats in each group. The experiment was conducted over a period of three weeks and the first group served as a control, while the other groups (G1, G2, and G3) served as experimental groups. The results of evaluating some antioxidants (SOD, CAT, GSTs, and TAOC) and some oxidants (MDA, NO). revealed a clear imbalance between oxidants and antioxidants, increased oxidative stress, pathological changes in lung tissue such as enlargement and widening of the alveoli, and an increase in endothelial thickness. On the other hand, the rutin dosage increased antioxidants, decreased oxidative stress, and improved lung tissue to levels equivalent to the control group

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Reports on the topic "Mucoprotective effect and Experimental rats"

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Lawanprasert, Somsong, Chaiyo Chaichantipyuth, Supatra Srichairat, Nuansri Niwattisaiwong, and Laddawal Phivthong-ngam. Subchronic exposure of Pueraria mirifica in normal - and high cholesterol diet fed rats : influence on hepatic cytochrome P450, lipid profile and toxicity. Chulalongkorn University, 2004. https://doi.org/10.58837/chula.res.2004.28.

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Abstract:

Pueraria mirifica airy shaw and suvatabandhu, know locally as Kwao Keur, is a plant in family Leguminosae. In this study, effects of P.mirifica on hepatic cytochrome P450 (CYP), serum lipid profile and subchronic toxicity were investigated in male Wistar rats. Rats were randomly divided into four treatment groups as following: normal diet-fed group; normal diet-fed supplemented with P.mirifica group; high cholesterol diet-fed group; high cholesterol diet-fed supplemented with P.mirifica group. Each group comprised 10 rats. P.mirifica was administered orally at a dosage of 100 mg/kg/day for 90 consecutive days. At the end of the treatment, animals were anesthesized. Blood samples were collected by heart puncture and serum sample were prepared for determination of hematology and clinical blood chemistry, respectively. Microsomes were prepared from livers for enzyme assays. The results showed that body weight of rats given P.mirifica in either normal diet or high cholesterol diet conditions were significantly lower than their corresponding control groups. There was no significant difference of these following hematology and clinical blood chemistry: hemoglobin, hemotocrit, WBC count, %differential WBC, platelet count, RBC morphology, glucose, BUN, SCr, total bilirubin, and direct bilirubin in all experimental groups. P.mirifica did not affect serum level of AST, ALT, and ALP in normal diet-fed condition. High cholesterol diet-fed condition caused a significant increase of AST, ALT, and ALP but P.mirifica attenuated these effects. P.mirifica significantly decreased serum total cholesterol and LDL-C in either normal diet-fed or high cholesterol diet-fed rats. Serum triglyceride was increased in normal diet-fed rats but decreased in high cholesterol diet-fed rats. P.mirifica caused a significant decrease of HDL-C in both normal and high cholesterol diet-fed rats whereas its improvement in the LDL-C/HDL-C ratio was shown only in high cholesterol diet-fed rats. Concerning the effects on CYPs, P.mirifica significantly inhibited CYP2B1&B2 in either normal diet or high cholesterol diet-fed rats. Its inhibitory effect of CYP1A2 and CYP2E1 was found only in normal diet-fed rats. No effect of P.mirifica was found on CYP1A1 and CYP3A. Inhibitory effects of P.mirifica on CYP2B1&2B2 and CYP2E1 were also found in the in vitro study. Although, P.mirifica demonstrated a benefit on lipid profile and did not show any toxic effects on liver, kidney, and blood system in this study, an increment of serum triglyceride in normal rat receiving P.mirifica, howerer, is not favorable. Inhibitory effects of P.mirifica on CYP1A2, CYP2B1&2B2 and CYP2E1 indicated a beneficial potential of this plant regarding the chemical-induced carcinogenesis as well as a possible potential of this plant regarding drug-drug interaction with other medicines that are metabolized by these CYPs. Effects of P.mirifica at various doses, long term used as well as mechanism of effects should be further investigated. Effects of P.mirifica on other isoforms of CYP in human should also be explored.

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