Log in

Relevant bibliographies by topics / Mucoprotective effect and Experimental rats / Journal articles

To see the other types of publications on this topic, follow the link: Mucoprotective effect and Experimental rats.

Journal articles on the topic 'Mucoprotective effect and Experimental rats'

Author: Grafiati

Published: 3 June 2025

Last updated: 13 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Mucoprotective effect and Experimental rats.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Mehnoor, Farheen *. Rahmata Yasmeen *. Samreen Ayesha Sana Sara mizna Saleha sultana. "PHYTOCHEMICAL EVALUATION AND PHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACT OF AERIAL PARTS OF POLYGONUM GLABRUM FOR ANTIULCER ACTIVITY IN WISTAR RATS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 02 (2018): 872–81. https://doi.org/10.5281/zenodo.1175794.

Full text

Abstract:

Polygonum glabrum has been used to treat peptic ulcer disease , but its efficacy has not been validated. The present study was therefore carried out to evaluate the anti-ulcer activity of 75% ethanolic aerial extract of polygonum glabrum in wistar rats. The Antiulcer Activity of 75% ethanolic aqueous extract of aerial parts of Polygonum glabrum at a dose of 200, 400 mg/kg b.w p.o was investigated in Diclofenac induced ulcers in Albino Wistar rats (180-230 gm). In this model parameters evaluated are gastric volume, total acidity, free acidity and ulcer index. There was no mortality up to a dose of 2000 mg/kg b.w p.o indicating the safety of the plant. Preliminary Phytochemical studies showed the presence of Carbohydrates, Flavanoid, Glycosides, Tannins, Protein, Terpenes and Volatile Oils. 75% ethanolic aqueous extract of Polygonum glabrum at a dose of 200,400 mg/kg b.w p.o produced significant reduction of ulcers in diclofenac induced ulcer Model as compared to control group by decreasing gastric volume, total acidity, free acidity and severity of ulcer. The ulcer protective effect of extract was comparable with that of the standard drugs. Results of study suggest that 75% ethanolic aqueous extract of Polygonum glabrum posses Mucoprotective effect which may be due to the presence of flavanoids in the extract as it has an astringent property. Keywords: Antiulcer activity, Polygonum glabrum, Diclofenac, Mucoprotective effect and Experimental rats.

APA, Harvard, Vancouver, ISO, and other styles

2

Eutamene, Hélène, Catherine Beaufrand, Cherryl Harkat, and Vassilia Theodorou. "Effect of Two Mucoprotectants, Gelatin Tannate and Xyloglucan plus Gelatin, on Cholera Toxin-Induced Water Secretion in Rats." Gastrointestinal Disorders 4, no. 4 (2022): 324–32. http://dx.doi.org/10.3390/gidisord4040030.

Full text

Abstract:

Background: Newer antidiarrheal agents include the mucoprotectants gelatin tannate and xyloglucan. Methods: Rat models of cholera toxin (CT)-induced water secretion were used to evaluate the mucoprotective effects of gelatin tannate, xyloglucan, and related compounds. Results: Oral pretreatment for 4 days with gelatin tannate (250 and 500 mg/kg/day), but not tannic acid or gelatin (both 125 mg/kg/day), blocked CT-induced intestinal water secretion. CT-induced intestinal water secretion was also attenuated by oral xyloglucan 12.5 mg/kg + gelatin 125 mg/kg (6 h pre-CT) and gelatin 250 mg/kg (12 h pre-CT), and by local (intra-jejunal loop) administration of gelatin, gelatin tannate and xyloglucan concomitantly with CT. Conclusions: Gelatin tannate and xyloglucan + gelatin attenuated CT-induced intra-loop water secretion in this experimental model, supporting previous evidence that their mechanisms of mucosal protection are closely related to their chemical structures, which confer film-forming properties via the formation of mucoadhesive films.

APA, Harvard, Vancouver, ISO, and other styles

3

Ko, Il-Gyu, Jun-Jang Jin, Lakkyong Hwang та ін. "Evaluating the mucoprotective effect of polydeoxyribonucleotide against indomethacin-induced gastropathy via the MAPK/NF-κB signaling pathway in rats". European Journal of Pharmacology 874 (травень 2020): 172952. http://dx.doi.org/10.1016/j.ejphar.2020.172952.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kemeir. "HEPATOTOXIC EFFECT OF ITRACONAZOLE IN EXPERIMENTAL RATS." American Journal of Animal and Veterinary Sciences 9, no. 1 (2014): 46–52. http://dx.doi.org/10.3844/ajavsp.2014.46.52.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

OKUNO, Takehiko, Yoshiyuki SEYAMA, and Saburo YAMASHITA. "Effect of Elastase on Experimental Atherosclerotic Rats." Journal of Japan Atherosclerosis Society 14, no. 3 (1986): 577–83. http://dx.doi.org/10.5551/jat1973.14.3_577.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kim, Chul Min, Jun Chul Park, In Soo Park, et al. "Effect of Reperfusion Experimental Myocardial Infarction in Rats." Korean Circulation Journal 18, no. 1 (1988): 57. http://dx.doi.org/10.4070/kcj.1988.18.1.57.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Rosa-e-Silva, JC, GG Fortunato, JVC Zanardi, J. Meola, and AA Nogueira. "Effect of Cabergoline in Experimental Endometriosis in Rats." Journal of Minimally Invasive Gynecology 22, no. 6 (2015): S168. http://dx.doi.org/10.1016/j.jmig.2015.08.627.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Sekar, Natesanpillai, Anumanthan Kanthasamy, Samuel William, Natarajan Balasubramaniyan, and Saminathan Govindasamy. "Antioxidant effect of vanadate on experimental diabetic rats." Acta Diabetologica Latina 27, no. 4 (1990): 285–93. http://dx.doi.org/10.1007/bf02580932.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Jaiswal, Dolly, Prashant Kumar Rai, and Geeta Watal. "Antidiabetic effect of Withania coagulans in experimental rats." Indian Journal of Clinical Biochemistry 24, no. 1 (2009): 88–93. http://dx.doi.org/10.1007/s12291-009-0015-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Srinivasan, K., K. Platel, and M. V. L. Rao. "Hypotriglyceridemic effect of dietary vanillin in experimental rats." European Food Research and Technology 228, no. 1 (2008): 103–8. http://dx.doi.org/10.1007/s00217-008-0911-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

mohammed., Baydaa ghanim. "Effect of Sorbitol on Some Physiological and Biochemical Parameters in Diabetic Rats." Al-Anbar Journal of Veterinary Sciences 17, no. 1 (2024): 84–93. http://dx.doi.org/10.37940/ajvs.2024.17.1.11.

Full text

Abstract:

This study aims to estimate the role of sorbitol consumption in diabetic rats. Sixty male rats were purchased, acclimatized and divided into four groups; negative-control rats were received distilled water, positive-control rats were administered glucose orally, experimental-1 diabetic rats were administered sorbitol 100 mg and experimental-2 rats were administered sorbitol 200 mg orally. After 60 days, sera were collected and tested quantitatively by enzyme-linked immunosorbent assay. Glucose elevation was seen in experimental-2 but not in experimental-1; while insulin was increased significantly in rats of both experimental-1 and experimental-2 but decreased in rats of positive-control when compared to those of negative-control. Although catalase, glutathione peroxidase and superoxide dismutase were decreased significantly in experimental-1, experimental-2 and positive-control, malondialdehyde was elevated significantly in these groups when compared to values of negative-control. For lipid profile, lower high-density lipoprotein were showed in experimental-1 and experimental-2 and more severely in the positive-control than negative-control group; while values of low-density lipoprotein were elevated significantly in positive-control but not in experimental-1 and experimental-2 when compared to negative-control. Values of triglyceride varied insignificantly in experimental-1 and experimental-2; however, they increased significantly in comparison with negative-control but not to positive-control. To our knowledge, this experiment represented the first in vivo study to evaluate the effect of sorbitol on biochemical and biomarkers of diabetic rats. Our findings revealed the safety of sorbitol at low dose but the risk might increase at a higher dose. Therefore, it was necessary to investigate the effects of sorbitol consumption in healthy and diseased individuals.

APA, Harvard, Vancouver, ISO, and other styles

12

Cole, Daniel J., Jeffrey C. Nary, Lowell W. Reynolds, Piyush M. Patel, and John C. Drummond. "Experimental Subarachnoid Hemorrhage in Rats." Anesthesiology 87, no. 6 (1997): 1486–93. http://dx.doi.org/10.1097/00000542-199712000-00028.

Full text

Abstract:

Background Hemodilution with diaspirin crosslinked hemoglobin (DCLHb) ameliorates occlusive cerebral ischemia. However, subarachnoid hemoglobin has been implicated as a cause of cerebral hypoperfusion. The effect of intravenous DCLHb on cerebral perfusion and neuronal death after experimental subarachnoid hemorrhage was evaluated. Methods Rats (n = 48) were anesthetized with isoflurane and subarachnoid hemorrhage was induced by injecting 0.3 ml of autologous blood into the cistema magna. Each animal received one of the following regimens: Control, no hematocrit manipulation; DCLHb, hematocrit concentration decreased to 30% with DCLHb; or Alb, hematocrit concentration decreased to 30% with human serum albumin. The experiments had two parts, A and B. In part A, after 20 min, cerebral blood flow (CBF) was assessed with 14C-iodoantipyrine autoradiography. In part B, after 96 h, in separate animals, the number of dead neurons was determined in predetermined coronal sections by hematoxylin and eosin staining. Results Cerebral blood flow was greater for the DCLHb group than for the control group; and CBF was greater for the Alb group than the other two groups (P &lt; 0.05). In one section, CBF was 45.5 +/- 10.9 ml x 100 g(-1) x min(-1) (mean +/- SD) for the control group, 95.3 +/- 16.6 ml x 100 g(-1) x min(-1) for the DCLHb group, and 138.1 +/- 18.7 ml x 100 g(-1) x min(-1) for the Alb group. The number of dead neurons was less in the Alb group (611 +/- 84) than in the control group (1,097 +/- 211), and was less in the DCLHb group (305 +/- 38) than in the other two groups (P &lt; 0.05). Conclusions These data support a hypothesis that hemodilution decreases hypoperfusion and neuronal death after subarachnoid hemorrhage. The data do not support the notion that intravascular molecular hemoglobin has an adverse effect on brain injury after subarachnoid hemorrhage.

APA, Harvard, Vancouver, ISO, and other styles

13

Baliga, R., M. Baliga, and S. V. Shah. "Effect of selenium-deficient diet in experimental glomerular disease." American Journal of Physiology-Renal Physiology 263, no. 1 (1992): F56—F61. http://dx.doi.org/10.1152/ajprenal.1992.263.1.f56.

Full text

Abstract:

We examined the effect of a selenium-deficient diet on two experimental models of glomerular disease, the puromycin aminonucleoside (PAN)-induced nephrotic syndrome, a model of minimal change disease, and passive Heymann nephritis, a complement-dependent and neutrophil-independent model that resembles membranous nephropathy. The specific activity of selenium-dependent glutathione peroxidase was markedly reduced in the liver, the kidney cortex, and in glomeruli in weanling male Sprague-Dawley rats placed on a selenium-deficient diet for 6 wk compared with rats fed a selenium-replete diet, with no significant differences in the specific activities of superoxide dismutase or catalase. PAN-injected selenium-deficient rats had a marked and significantly greater proteinuria throughout the course of the experiment compared with PAN-injected selenium-replete rats with no significant histological differences. In the passive Heymann nephritis model induced by injecting anti-Fx1A immunoglobulin G, rats fed a selenium-deficient diet had significantly higher urinary protein (day 5: 91 +/- 16 mg/24 h, n = 10) compared with rats fed a selenium-replete diet (52 +/- 5 mg/24 h, n = 11) with no differences in the amount of antibody deposited in the kidney. The most likely explanation for the effect of a selenium-deficient diet is that selenium deficiency resulted in a marked reduction of glutathione peroxidase, thus indicating an important role of glutathione peroxidase in these models of glomerular injury.

APA, Harvard, Vancouver, ISO, and other styles

14

Almeida, José Luiz Jesus de, José Jukemura, Sandra Nassa Sampietre, Rosely Antunes Patzina, José Eduardo Monteiro da Cunha, and Marcel Cerqueira César Machado. "Effect of hyperthermia on experimental acute pancreatitis." Arquivos de Gastroenterologia 43, no. 4 (2006): 316–20. http://dx.doi.org/10.1590/s0004-28032006000400014.

Full text

Abstract:

BACKGROUD: Recent studies indicate that hyperthermia can change inflammatory mechanisms and protect experimental animals from deleterious effects of secretagogue-induced acute pancreatitis AIM: To evaluate the effects of hyperthermia post-treatment on cerulein-induced acute pancreatitis in rats METHODS: Twenty animals were divided in two groups: group I (n = 10), rats with cerulein-induced acute pancreatitis undergone hyperthermia, and group II (n = 10), animals with cerulein-induced acute pancreatitis that were kept normothermic. In all groups, amylase serum levels, histologic damage, vascular permeability and pancreatic water content were assessed. Acute pancreatitis was induced by administration of two cerulein injections (20 mcg/kg). A single dose of Evans' blue dye was administered along with the second dose of cerulein. All animals also received a subcutaneous injection of saline solution. After this process, animals undergone hyperthermia were heated in a cage with two 100 W lamps. Body temperature was increased to 39.5ºC and maintained at that level for 45 minutes. Normothermia rats were kept at room temperature in a second cage RESULTS: Control animals had typical edema, serum amylase activity and morphologic changes of this acute pancreatitis model. Hyperthermia post-treatment ameliorated the pancreatic edema, whereas the histologic damage and the serum amylase level remained unchanged CONCLUSIONS: The findings suggest a beneficial effect of the thermal stress on inflammatory edema in experimental acute pancreatitis.

APA, Harvard, Vancouver, ISO, and other styles

15

Suleyman, Bahadir, Renad Mammadov, Adalet Ozcicek, et al. "Effect of benidipine on experimental gastric ulcers in rats." Medicine Science | International Medical Journal 7, no. 4 (2018): 1. http://dx.doi.org/10.5455/medscience.2018.07.8921.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Mikheytseva, Irina N. "Protective Effect of Melatonin in Experimental Glaucoma in Rats." International Journal of Physiology and Pathophysiology 5, no. 1 (2014): 33–39. http://dx.doi.org/10.1615/intjphyspathophys.v5.i1.30.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Govindaraj, Jayamathi, Keerthidaa Govindaraj, U. Vidyarekha, and Kesavaram Padmavathy. "Antiinflammatory effect of Proanthocyanidins in experimental Periodontitis in rats." Research Journal of Pharmacy and Technology 12, no. 10 (2019): 4747. http://dx.doi.org/10.5958/0974-360x.2019.00818.7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gallant, Steven, Maria Kukley, Sergey Stvolinsky, Elena Bulygina, and Alexander Boldyrev. "Effect of Carnosine on Rats under Experimental Brain Ischemia." Tohoku Journal of Experimental Medicine 191, no. 2 (2000): 85–99. http://dx.doi.org/10.1620/tjem.191.85.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

NISHIYAMA, Hitoshi. "Effect of Fluoride on Experimental Periodontal Lesion in Rats." Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 35, no. 1 (1993): 95–112. http://dx.doi.org/10.2329/perio.35.95.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Abd EL Maksoud, Hussine, omnia Abd El Hamid, Mona M., and M. O. Emara. "Biochemical Effect of Cholchicine on Experimental Leukemia in Rats." Benha Veterinary Medical Journal 35, no. 1 (2018): 84–93. http://dx.doi.org/10.21608/bvmj.2018.38203.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

TAKEDA, Satoshi, Toshikazu YOSHIKAWA, Yutaka MORITA, Norimasa YOSHIDA, and Motoharu KONDO. "Effect of Zinc on Experimental Acute Pancreatitis in Rats." Journal of Clinical Biochemistry and Nutrition 26, no. 3 (1999): 213–25. http://dx.doi.org/10.3164/jcbn.26.213.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Subramanian, Perumal, and Selvaraju Subash. "Chronotherapeutic effect of morin in experimental chronic hyperammonemic rats." International journal of Nutrition, Pharmacology, Neurological Diseases 2, no. 3 (2012): 266. http://dx.doi.org/10.4103/2231-0738.99483.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Corsi, Massimiliano M., Chiara Ticozzi, Carmela Netti, et al. "The Effect of Somatostatin on Experimental Inflammation in Rats." Anesthesia & Analgesia 85, no. 5 (1997): 1112–15. http://dx.doi.org/10.1097/00000539-199711000-00028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Corsi, Massimiliano M., Chiara Ticozzi, Carmela Netti, et al. "The Effect of Somatostatin on Experimental Inflammation in Rats." Anesthesia & Analgesia 85, no. 5 (1997): 1112–15. http://dx.doi.org/10.1213/00000539-199711000-00028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Wenzel, U. O., F. Thaiss, U. Panzer, et al. "Effect of renovascular hypertension on experimental glomerulonephritis in rats." Journal of Laboratory and Clinical Medicine 134, no. 3 (1999): 292–303. http://dx.doi.org/10.1016/s0022-2143(99)90210-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Iizuka, Yukisumi, Eiichi Sakurai, Kazumi Maeda, and Nohoru Hikichi. "The preventive effect of selenium on experimental hypercholesterolemia rats." Japanese Journal of Pharmacology 67 (1995): 99. http://dx.doi.org/10.1016/s0021-5198(19)46361-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Pétoux, F., E. Chevalier, M. Chovet, and A. Langlois. "Effect of trimebutine maleate on experimental colitis in rats." Gastroenterology 114 (April 1998): A1060. http://dx.doi.org/10.1016/s0016-5085(98)84314-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Sagara, Nina, Takahiro Kawaji, Akiomi Takano, et al. "Effect of pitavastatin on experimental choroidal neovascularization in rats." Experimental Eye Research 84, no. 6 (2007): 1074–80. http://dx.doi.org/10.1016/j.exer.2007.02.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

MIYAZAWA, Tomoaki, Chie MURAYAMA, and Hidehiko NAKAGAWA. "Effect of lisuride on experimental cerebral infarction in rats." Folia Pharmacologica Japonica 98, no. 6 (1991): 449–56. http://dx.doi.org/10.1254/fpj.98.6_449.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Forcelli, Patrick A., David Kalikhman, and Karen Gale. "Delayed Effect of Craniotomy on Experimental Seizures in Rats." PLoS ONE 8, no. 12 (2013): e81401. http://dx.doi.org/10.1371/journal.pone.0081401.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Giglio, Máximo Juan, and Maria Anabel Lama. "Effect of experimental diabetes on mandible growth in rats." European Journal of Oral Sciences 109, no. 3 (2001): 193–97. http://dx.doi.org/10.1034/j.1600-0722.2001.00032.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

de Kozak, Yvonne, Jean-Phillip Nordman, Jean-Piere Faure, Narsing A. Rao, and George E. Marak, Jr. "Effect of Antioxidant Enzymes on Experimental Uveitis in Rats." Ophthalmic Research 21, no. 3 (1989): 230–34. http://dx.doi.org/10.1159/000266813.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Grauballe, M. C. B., B. H. Bentzen, M. Bjornsson, et al. "The effect of spironolactone on experimental periodontitis in rats." Journal of Periodontal Research 40, no. 3 (2005): 212–17. http://dx.doi.org/10.1111/j.1600-0765.2005.00792.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

SHICHINOHE, Kazuhiro, Masumi SHIMIZU, and Kazuo KUROKAWA. "Effect of M-711 on Experimental Asthma in Rats." Journal of Veterinary Medical Science 58, no. 1 (1996): 55–59. http://dx.doi.org/10.1292/jvms.58.55.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Pang, JiSong, Songchan Han, and Yongsu Ri. "Effect of Propolis on Experimental Allergic Conjunctivitis in Rats." International Journal of Clinical and Experimental Physiology 9, no. 3 (2023): 128–30. http://dx.doi.org/10.5530/ijcep.2022.9.3.30.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Abbassy, Mona Aly, Ippei Watari, and Kunimichi Soma. "Effect of experimental diabetes on craniofacial growth in rats." Archives of Oral Biology 53, no. 9 (2008): 819–25. http://dx.doi.org/10.1016/j.archoralbio.2008.02.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Taniguchi, Shirley F., Ciomar A. Bersani-Amado, Lia S. Sudo, Silvana M. C. Assef, and Seizi Oga. "Effect ofPfaffia iresinoideson the experimental inflammatory process in rats." Phytotherapy Research 11, no. 8 (1997): 568–71. http://dx.doi.org/10.1002/(sici)1099-1573(199712)11:8<568::aid-ptr164>3.0.co;2-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Zakrzeska, Agnieszka, Paweł Kitlas, Alexej Shlyahtun, Natalia Szymańska, Ryszard Jabłoński, and Mikołaj Tomulewicz. "Hypoglycemic Effect of Betulin in Rats With Experimental Diabetes." Acta Poloniae Pharmaceutica - Drug Research 80, no. 5 (2023): 795–804. http://dx.doi.org/10.32383/appdr/172620.

Full text

Abstract:

Betulin is natural pentacyclic triterpenoids lupane-structure, which shows a wide range of biological activity, including possibly hypoglycemic effects. Diabetes mellitus is a metabolic disease, accompanied by chronic hyperglycemia caused by absolute or relative insulin deficiency. The main effective drug in the treatment of type 1 diabetes is insulin injections. In the case of type 2 diabetes, it is an adjuvant therapy. To purpose of this study was to show hypoglycemic action of betulin in a model of experimentally induced diabetes in rats. For the induction of diabetes, alloxan at a dose of 170 mg/kg, i.p. was used. The hypoglycemic effect of betulin was evaluated using doses of 50 and 100 mg/kg/day for 30 days. The activity of glucose metabolism enzymes: liver glycogen phosphorylase, hexokinase and liver and skeletal muscle phosphofructokinase in rats, glucose-6-phosphate dehydrogenase (DG-6-P) of the liver was also evaluated. Betulin in a dose-dependent manner normalized of glycemia, increased the basal insulin concentration in the blood serum, increased the activity of carbohydrate metabolizing enzymes and on the gene expression profile of enzymes involved in carbohydrate metabolism. Betulin also significant improved the morphology of the pancreas. In particular, there was an increase in the area of the islands, their diameter, an increase in the number of β cells in the composition of the islands. We conclude that betulin has hypoglycemic properties, improving glycemia and carbohydrate metabolizing enzymes and pancreatic morphology.

APA, Harvard, Vancouver, ISO, and other styles

39

Honour, J. W., S. P. Borriello, U. Ganten, and P. Honour. "Antibiotics attenuate experimental hypertension in rats." Journal of Endocrinology 105, no. 3 (1985): 347–50. http://dx.doi.org/10.1677/joe.0.1050347.

Full text

Abstract:

ABSTRACT Hypertension was produced in Sprague–Dawley rats by intramuscular injections of either corticosterone or ACTH. Lower increases in blood pressure to these challenges were observed in Sprague–Dawley rats pretreated with neomycin or vancomycin which alone had no effect on blood pressure or growth. The development of high blood pressure in spontaneously hypertensive rats of a stroke-prone substrain was also attenuated by oral administration of neomycin. These results suggest that experimental hypertension can be modulated by the administration of antibiotics. J. Endocr. (1985) 105, 347–350

APA, Harvard, Vancouver, ISO, and other styles

40

Rupeshkumar, Mani. "HYPOGLYCEMIC EFFECT OF ANDROGRAPHIS ECHIOIDES ON STREPTOZOTOCIN INDUCED EXPERIMENTAL RATS." Journal of Applied Pharmacy 7 (2015): 55. http://dx.doi.org/10.21065/19204159.7.55.

Full text

Abstract:

The present study aims to study the hypoglycemic effect of methanol extract of Andrographisechioides (MEAE) in streptozotocin (STZ)-induced diabetic Wistar rats. Hyperglycemia was induced in rats by single intraperitoneal injection of STZ (55 mg/kg bodyweight). Three days after STZ induction, the hyperglycemic rats were treated with MEAE orally at the doses of 200, 500, and 800 mg/kg body weight daily for 21 days. Glibenclamide (1 mg/kg, orally) was used as reference drug. The fasting blood glucose levels were measured on each 7th day during the 21 days of treatment.

APA, Harvard, Vancouver, ISO, and other styles

41

Toygar, Ismail, Aynur Tureyen, Derya Demir, and Sevki Cetinkalp. "Effect of allicin on wound healing: an experimental diabetes model." Journal of Wound Care 29, no. 7 (2020): 388–92. http://dx.doi.org/10.12968/jowc.2020.29.7.388.

Full text

Abstract:

Objective: The aim of this study was to investigate the effect of allicin on wound healing in an experimental diabetes model. Method: In this randomised controlled study, 50 Wistar albino rats (25 females, 25 males) each weighing 200–300g were used. To develop the diabetes model, 30 rats were induced with 50mg/kg streptozotocin (STZ); 20 rats were not induced in order to compare diabetic and nondiabetic rats. The diabetic rats were divided into three groups, according to dressing material used (allicin, physiological serum and control, where no dressing was used), and the nondiabetic rats were divided into two groups (allicin and control, where no dressing was used). The wound area was calculated and recorded on days 0, 7, 14 and 21. In addition, biopsies were taken from the wound area on days 0, 7, 14 and 21 and used for microscopic examination. Day 0 was used as a reference to calculate wound healing percentage. Results: On days 7 and 14, there were statistically significant differences between groups. Wound surface areas were smaller in the allicin group than in other groups on days 7 and 14. There were no statistically significant differences between the groups on day 21. In addition, it was determined that neutrophil, mononuclear cell, intraepithelial oedema and dermal oedema density were lower and fibroblast, angiogenesis and collagen density were higher in the allicin groups on days 7 and 14. Conclusion: In this study, allicin was found to be potentially effective on wound healing. Future research should be conducted in order to clarify how it affects wound healing.

APA, Harvard, Vancouver, ISO, and other styles

42

Le Page, C., A. Ferry, and M. Rieu. "Effect of muscular exercise on chronic relapsing experimental autoimmune encephalomyelitis." Journal of Applied Physiology 77, no. 5 (1994): 2341–47. http://dx.doi.org/10.1152/jappl.1994.77.5.2341.

Full text

Abstract:

We examined whether physical exercise affected the development of an autoimmune response, experimental autoimmune encephalomyelitis (EAE), which is a demyelinating disease leading to paralysis. EAE was inducted on day 0, in rats of both sexes, by injecting them with spinal cord tissue in adjuvant. From days 1 to 10 after injection, exercised rats (n = 55) ran on a treadmill (60–120 min/day) before the onset of the paralytic disease. Clinical signs of the disease (ataxia, paralysis, and body mass loss) were examined in exercised and control rats (n = 54). Three types of EAE were induced: monophasic, acute, and chronic relapsing (CR)-EAE (3 bouts of disease, CR-EAE 1, 2, and 3, separated by remissions). Exercise significantly delayed the onset of CR-EAE 1 (P = 0.001) and the 1st day of maximum severity of CR-EAE 1 (P = 0.001) and CR-EAE 2 (P = 0.002). Moreover, the duration of CR-EAE 1 was significantly decreased in exercised rats compared with control rats (P = 0.004). The peak severity of the different types of EAE was not modified by exercise. The present study indicates that endurance exercise during the phase of induction of EAE diminished lightly only one type of EAE (CR-EAE) and therefore did not exacerbate the autoimmune disease.

APA, Harvard, Vancouver, ISO, and other styles

43

Kaya, CA, R. Guler, MC Yavuz, EC Ozcan, A. Bozoglan, and S. Dundar. "Does Fasting and High-Fatty Diet Effect Ossseointegration: An Experimental Study." Nigerian Journal of Clinical Practice 28, no. 1 (2025): 19–26. https://doi.org/10.4103/njcp.njcp_835_23.

Full text

Abstract:

Background: Hyperlipidemia caused by a high-fat diet (HFD) has many adverse effects on the cardiovascular system, including vascular problems. In addition, a high-fat diet has significant adverse effects on bone health. Aim: This study aimed to investigate the levels of bone–implant connection in rats subjected to fasting and a high-fatty diet. Methods: This study utilized a sample size of 28 female Spraque–Dawley rats. The rats were divided into four groups, with 7 rats in each group; the control group on a normal diet (Group 1) (n = 7), the fasted group (Group 2) (n = 7), the high-fatty diet (HFD) group (Group 3) (n = 7), and the fasted and high-fat diet (Group 4) (n = 7). Machined surfaced titanium implants with a diameter of 2.5 mm and a length of 4 mm were placed in the right tibia bones of the subjects. All rats that continued the administered diet for 12 weeks were sacrificed at the end of the experimental period. The implants and the surrounding bone tissue were surgically removed and subjected to biomechanical analysis to assess bone–implant osteintegration. Results: There was no statistically significant difference in bone–implant osteointegration (P > 0,05) between the rats in the control group and the other three groups. Conclusion: This study determined that fasting or maintaining a high-fat diet does not adversely affect the bone–implant connection in rats’ tibias.

APA, Harvard, Vancouver, ISO, and other styles

44

Begum, Amina, Md Shaiful Islam Patwary, Adity Ara Trisha, and Shorifa Shahjadi. "Effect of sidestream cigarette smoking on memory of male Long-Evans rats." Bangabandhu Sheikh Mujib Medical University Journal 17, no. 1 (2024): e68731. http://dx.doi.org/10.3329/bsmmuj.v17i1.68731.

Full text

Abstract:

Background: Memory impairment is an important presentation of many diseases. Sidestream cigarette smoke (SCS), a form of passive smoke, causes neural complications such as impaired memory. The aim of this study was to assess the effect of sidestream cigarette smoke on memory of male Long-Evans rats. Methods: This experimental study was conducted in the Physiology Department of Bangabandhu Sheikh Mujib Medical University. Twelve male Long-Evans rats, having 150 to 200 grams body weight were collected from central animal house of this University. Rats were divided into fresh air group (control) and experimental group (exposer to SCS for 30 minutes twice daily) for 30 consecutive days. For memory evaluation, Morris water maze (MWM) test was performed. Working memory was measured as escape latency in training and four trial phases. Reference memory (escape latency in acquisition phase and target crossings in probe trial. For estimation of hippocampal antioxidant enzymes, catalase and glutathione peroxidase levels were measured by ELISA. Data were expressed as mean (standard error of mean) and t test was done to compare the two groups. P <0.05 was considered as statistically significant. Results: Two to five times higher escape latency (working memory) was observed in experimental rats compared to those of control rats (P<0.001). Moreover, significantly lower (3.8 versus 7.8) target crossings (P<0.001) were found in experimental rats compared to the control rats. In addition, hippocampal catalase (6.2 versus 17.6 U/mg protein) and glutathione peroxidase (1.9 versus 5.6 U/mg protein) levels were found significantly lower (P<0.001) in experimental rats when compared to control rats. Conclusion: The sidestream cigarette smoke caused memory impairment and decrement of hippocampal antioxidant enzymes level in male Long-Evans rats.

APA, Harvard, Vancouver, ISO, and other styles

45

Nevzorova, V. A., V. M. Chertok, T. A. Brodskaya, R. V. Roshchenko, and N. G. Plekhova. "Experimental modeling of myocardial infarction in old rats." Pacific Medical Journal, no. 2 (June 23, 2022): 72–74. http://dx.doi.org/10.34215/1609-1175-2022-2-72-74.

Full text

Abstract:

The results of modeling acute myocardial infarction on 20 male Wistar rats aged 24 months are presented. Ischemic effect is carried out by local injection of 1.5% sclerosant ethoxysclerol (0.25 ml) into the thickness of the myocardium under general anesthesia using non-traumatic needle with silicone coating, which allows to simulate acute myocardial infarction with minimal invasive effect on the animal's body, minimal trauma, little duration of intervention, low mortality, frequency of complications and absence of systemic action of drugs.

APA, Harvard, Vancouver, ISO, and other styles

46

Li, Jingbo, Shuda Chen, Jing Fan, Gao Zhang, and Reng Ren. "Minocycline attenuates experimental subarachnoid hemorrhage in rats." Open Life Sciences 14, no. 1 (2019): 595–602. http://dx.doi.org/10.1515/biol-2019-0067.

Full text

Abstract:

AbstractBackgroudThe aim of this study was to evaluate the therapeutic effect of minocycline on treating experimental subarachnoid hemorrhage (SAH) in rats and to explore its possible molecular mechanism.MethodsSAH was induced in male Sprague-Dawley rats by endovascular perforation. The rats were treated with minocycline (25 mg/kg or 50 mg/kg) or saline at 2 hand 12 h post SAH. Neurological function, cerebral hemorrhage, and edema were scored at 48 h post SAH. Cell death and P2X4 receptor (P2X4R) expression were observed in the prefrontal cortex (PFC).ResultsTreatment with a highdose of minocycline significantly improved the neurological function score, and attenuated cerebral hemorrhage and edema. Low-dose minocycline could reduce hemorrhage, but the effect on neurological deficits and brain edema was not obvious. Minocycline treatment could alleviate neuronal apoptosis in the PFC, which was related to reduced expression of inflammatory cytokines. Immunofluorescence showed that P2X4R on microglia was activated after SAH. Minocycline treatment inhibited P2X4R activation and further suppressed the phosphorylation of downstream p38 MAPK.ConclusionsMinocycline plays a neuroprotective role by attenuating early brain injury after experimental SAH. The therapeutic mechanism of minocycline may be mediated by the inhibition of P2X4R on microglia.

APA, Harvard, Vancouver, ISO, and other styles

47

Gomes, Lyvia Maria Rodrigues de Sousa, Nicolau Gregori Czeczko, Rayanne Luiza Tajra Mualem Araújo, Maria do Socorro de Sousa Cartagenes, José Osvaldo Barbosa Neto, and João Batista Santos Garcia. "Effect of intra-articular dexmedetomidine on experimental osteoarthritis in rats." PLOS ONE 16, no. 1 (2021): e0245194. http://dx.doi.org/10.1371/journal.pone.0245194.

Full text

Abstract:

Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study assessed the analgesic and anti-inflammatory effects of dexmedetomidine administered via the i.a. route in different doses in an experimental model of rat knee osteoarthritis induced with monosodium iodoacetate. Rats were allocated to four groups with 24 animals in each group. The OA (osteoarthritis), DEX-1 (dexmedetomidine in dose of 1μg/kg) and DEX-3 (dexmedetomidine in dose of 3μg/kg) groups were subjected to induction of osteoarthritis through injection of monosodium iodoacetate (MIA) via the i.a. route on the right knee; the control group was not subjected to osteoarthritis induction. Clinical assessment was performed on day 0 (before osteoarthritis induction) and then on days 5, 10, 14, 21 and 28 after induction. Treatment was performed on day 7 via the i.a. route, consisting of dexmedetomidine in doses of 1 and 3 μg/kg, while group OA received 0.9% normal saline. The animals were euthanized on days 7, 14, 21 and 28. Samples of the synovial membrane were collected for histopathological analysis, and the popliteal lymph nodes were collected for measurement of cytokines (interleukin [IL] IL-6, tumor necrosis factor alpha [TNF-α]). Dexmedetomidine (1 and 3 μg/kg) significantly reduced the animals’ weight distribution deficit during the chronic-degenerative stage of osteoarthritis and improved the pain threshold throughout the entire experiment. Histological analysis showed that dexmedetomidine did not cause any additional damage to the synovial membrane. The TNF-α levels decreased significantly in the DEX-3 group on day 28 compared with the OA group. Dexmedetomidine reduced pain, as evidenced by clinical parameters of osteoarthritis in rats, but did not have an anti-inflammatory effect on histological evaluation.

APA, Harvard, Vancouver, ISO, and other styles

48

Vyas, BhavinA, NiketY Desai, ParasK Patel, ShrikantV Joshi, and DineshR Shah. "Effect of Boerhaavia diffusa in experimental prostatic hyperplasia in rats." Indian Journal of Pharmacology 45, no. 3 (2013): 264. http://dx.doi.org/10.4103/0253-7613.111946.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Liu, Sheng, Xiao-min Wang, and Guo-wang Yang. "EFFECT OF RUANGANJIEDU DECOCTION INHIBIT EXPERIMENTAL HEPATIC FIBROSIS OF RATS." African Journal of Traditional, Complementary and Alternative medicines 14, no. 1 (2016): 242–50. http://dx.doi.org/10.21010/ajtcam.v14i1.26.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Silva, Priscilla Flores, Marcus Vinicius Henriques Brito, Flávia Sirotheau Correa Pontes, Suzana Rodrigues Ramos, Laís Cordeiro Mendes, and Louize Caroline Marques Oliveira. "Copaiba oil effect on experimental jaw defect in Wistar rats." Acta Cirurgica Brasileira 30, no. 2 (2015): 120–26. http://dx.doi.org/10.1590/s0102-86502015002000006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!