Relevant bibliographies by topics / Mucosa nasal

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Mucosa nasal'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Mucosa nasal"

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Chiba, Yoshihiko, Michiko Oshita, Kensuke Matsuo, Hiroyasu Sakai, and Miwa Misawa. "Comparison of Norepinephrine Responsiveness of Mucosal Veins in Vivo with that of Isolated Mucosal Tissue in Vitro in Guinea Pig Nasal Mucosa." American Journal of Rhinology 20, no. 3 (2006): 349–52. http://dx.doi.org/10.2500/ajr.2006.20.2853.

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Background The vascular responsiveness of nasal mucosa has been determined frequently by using isolated mucosal tissues although it is not clear whether the response of the whole tissue truly reflects the response of the vasculature (especially veins) in mucosa. In this study, the in vivo responsiveness of mucosal veins was compared with in vitro responsiveness of isolated mucosal tissue in guinea pig nasal septa. Methods The in vivo venous responsiveness to norepinephrine (NE) of guinea pig nasal septal mucosa was measured by changes in the diameters of mucosal veins, stereomicroscopically. The in vitro responsiveness to NE of isolated nasal septal mucosae from guinea pigs also was determined by standard organ-bath technique. Results Application of NE induced concentration-dependent contractile responses both in vivo and in vitro with the pD2 (negative logarithm for 50% effective concentration [M] of NE) values of 5.23 ± 0.29 and 5.00 ± 0.17, respectively. Conclusion The equal potencies obtained by the in vivo and in vitro experiments suggest that an increase in tension of isolated nasal mucosal tissue might be caused by the contraction of mucosal veins. Both the in vivo and the in vitro methods used in this study might be useful for determining vasoreactivity of nasal mucosa in experimental animals.
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Elsheikh, Ezzeddin, Mohammad El-Anwar, and Hesham Abdel-aziz. "Impact of Successful Choanal Atresia Repair on the Nasal Mucosa: A Preliminary Study." International Archives of Otorhinolaryngology 21, no. 03 (2017): 276–80. http://dx.doi.org/10.1055/s-0037-1601404.

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Introduction The main histological features of the nasal mucosa in choanal atresia are distorted cilia, marked increase of mucous submucosal glands associated with marked reduction of goblet cell density, and lymphocytic cellular infiltration. Objective To study the nasal mucosal changes in cases of choanal atresia after successful repair compared with pre-repair mucosal histological features. Methods Tissue samples were taken from the inferior turbinate of 3 patients (1 bilateral and 2 unilateral) who were successfully operated. Then, the biopsies were subjected to histopathological, histochemical and immunohistochemical studies. After that, the results were compared with pre-repair findings in the choanal atresia side and in the normal side. Results Four biopsies (4 repaired choanal atresia sides) of the mucosa of the inferior turbinate revealed that 1 patient (who had a bilateral choanal atresia repaired), after achieving a patent choana for 8 months, had not completely recovered a normal nasal mucosa. The other 2 patients, after 18 and 23 months of achieving a patent choana, showed normal nasal cavities. Conclusion The main histological features of the nasal mucosa in choanal atresia could be reversed by surgery, making the patients regain their choanal patency, with their mucosae changing back to normal gradually with time.
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Otsuka, Hirokuni, Kimihiro Ohkubo, Harumi Seki, Masaki Ohnishi, and Terumichi Fujikura. "Mast cell quantitation in nasal polyps, sinus mucosa and nasal turbinate mucosa." Journal of Laryngology & Otology 107, no. 5 (1993): 418–22. http://dx.doi.org/10.1017/s002221510012331x.

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The distribution and abundance of mast cells in nasal polyps, the maxillary sinus mucosa of patients with sinusitis and the turbinate mucosa of allergic rhinitis was microscopically examined using different methods of fixation. In the epithelium of the surface and the ducts of nasal polyps (n = 8), the mean number of mast cells was over 20,000 per mm3 using Mota's fixation and the increase was correlated with the epithelial thickness (P<0.05). On the other hand those of the maxillary sinus mucosa (n = 6) and the nasal turbinate mucosa (n = 7) were less than 6,000 per mm3. In the subepithelial layer or areas deeper than the area with the glands, however, mast cell counts were less than 3,200 per mm3 in all diseases. More than 70–90 per cent of all mast cells in the epithelium of the mucosal surface and the ducts of the polyp, the maxillary sinus mucosa and nasal turbinates were formalin sensitive. Most of the mast cells in the subepithelial and deeper areas were formalin resistant in all diseases.These results suggest that conditions for mast cell growth differ between polyps and the other diseases, and that the conditions which affect mast cells may contribute to polyp development.
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Morgan, Payam V., Jeffrey D. Suh, and Catherine J. Hwang. "Nasal Floor Mucosa." Ophthalmic Plastic and Reconstructive Surgery 32, no. 3 (2016): 174–77. http://dx.doi.org/10.1097/iop.0000000000000451.

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Corboz, Michel R., Maria A. Rivelli, Lori Varty та ін. "Pharmacological Characterization of Postjunctional α-Adrenoceptors in Human Nasal Mucosa". American Journal of Rhinology 19, № 5 (2005): 495–502. http://dx.doi.org/10.1177/194589240501900513.

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Background Functional α1- and α2-adrenoreceptor subtype pharmacology was characterized in an in vitro human nasal mucosa contractile bioassay. Methods Nasal mucosa was obtained from 49 donor patients and mucosal strips were placed in chambers filled with Krebs–Ringer solution and attached to isometric force transducers. Results Nonselective α-adrenoreceptor agonists epinephrine, norepinephrine, and oxymetazoline produced concentration-dependent contractions of isolated human nasal mucosa (pD2= 5.2, 4.9, and 6.5, respectively). The α2-adrenoreceptor agonist BHT-920 (10 μM)–induced contractions were blocked by yohimbine (0.01–1 μM) and prazosin (0.01–1 μM) inhibited the contractile response to the α1-adrenoreceptor agonist phenylephrine (10 μM). Histological analysis showed that phenylephrine and BHT-920 differentially contracted the arteries and veins of human nasal mucosa, respectively. Conclusion Our results indicate that functional α1- and α2-adrenoceptors are present and functional in human nasal mucosa. The a 2-adrenoceptors display a predominant role in contracting the veins and the α1-adrenoceptors appear to preferentially constrict the human nasal arteries.
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Saito, Hitoshi, and Toshihito Tsubokawa. "Ciliary Activity of Nasal Polyp and Mucosa in Chronic Sinusitis." American Journal of Rhinology 5, no. 6 (1991): 215–18. http://dx.doi.org/10.2500/105065891781874857.

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Ciliary activity of mucosal cells of nasal polyps and the maxillary sinus mucosa in chronic sinusitis cultured in vitro were measured by a photoelectric method. The findings were compared with those of normal maxillary sinus and inferior turbinate mucosae. The ciliary beating of edematous type of nasal polyp, 955 ± 130 beats/min (mean ± SD), did not differ significantly from the normal control, whereas both the duration and rate of ciliary beating were significantly decreased with cystic and fibrous type polyps. Ciliary activity in chronic sinusitis was significantly inhibited in the order of fibrous, purulent, and edematous types. The total area of ciliated mucosa also was decreased and varied with the type of chronic sinusitis, showing the most marked decrease with fibrous type. The ciliary activity in chronic sinusitis showed impairment with respect to both decreased ciliary rate of beating and reduced ciliated area.
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Tyurin, YU A., E. O. Sukmanskaya, S. N. Kulikov, and R. S. Fassakhov. "Chitinase-like protein YKL-40 from nasal mucosa as a biomarker of allergic rhinitis." Russian Journal of Allergy 9, no. 4 (2012): 13–17. http://dx.doi.org/10.36691/rja677.

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Background. Chitinase-like protein YKL-40 plays an important role in human atopic diseases. The aim of this study was to determine of the level of chitinase-like protein YKL-40 in the secretions of nasal mucosa of patients with chronic allergic rhinitis. Methods. Samples of allergic nasal mucosa were obtained from twelve patients with perennial allergic rhinitis. Measurement of nasal YKL-40 levels was performed with modification in duplicate using commercially available ELISA kits for YKL-40. The amount of nasal eosinophils and neutrophils were also determined. Results. There were significant differences between healthy volunteers and patients with allergic rhinitis for mucosal YKL-40 levels and the amount of nasal eosinophil and neutrophil cells, which have some characteristics closely associated with allergic response. The nasal YKL-40 levels in patients with allergic rhinitis were in tens times more higher than those in controls. Conclusion. Thus, we conclude that the level of chitinase-like protein YKL-40 was upregulated in allergic nasal mucosa compared with normal nasal mucosa, suggesting their roles in the pathogenesis of allergic rhinitis.
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Paulsson, Bodil, Thomas Gredmark, Pawel Burian, and Mats Bende. "Nasal mucosal congestion during the menstrual cycle." Journal of Laryngology & Otology 111, no. 4 (1997): 337–39. http://dx.doi.org/10.1017/s0022215100137259.

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AbstractA relationship between the reactivity of the nasal mucosa and changes in female sex hormones have been debated for a long time, although no evidence has been presented to prove or disprove this relationship. Nasal patency was therefore measured by nasal expiratory peak-flow in 26 women for two months in order to study changes in nasal mucosal congestion during the menstrual cycle. In another eight women, nasal congestion was measured by acoustic rhinometry, and symptoms of nasal stuffiness were registered during periods when there were various levels of plasma oestradiol and progesterone. Finally, nasal mucosal biopsies were taken for preparation of receptors for oestradiol and progesterone. This study could not verify the effects of female sex hormones on the nasal mucosa. This could be explained by the fact that no receptors for oestradiol and progesterone were found.
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Talmi, Yoav P., Jacob Bar-Ziv, David Cohen, Yehuda Finkelstein, and Jona Kronenberg. "Computed Tomography Study of Sinus Involvement in Ozena." American Journal of Rhinology 9, no. 5 (1995): 281–84. http://dx.doi.org/10.2500/105065895781808810.

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Atrophic rhinitis or ozena is a chronic nasal disease characterized by formation of foul smelling nasal crusts with subsequent turbinate mucosal atrophy and resorption of the underlying bone. This symptom complex involves nasal and sinus mucosa with resultant mucosal atrophy, as well as reduced or absent mucocilliary function. The question of the presence of sinusitis in ozena is yet unanswered. Mucosal atrophy may lead to widely patent sinus ostia, but it may well be that the nasal mucosal disease also involves the sinus mucosa with reduced ciliary motility and ensuing sinusitis. We have undertaken a prospective CT study of 11 ozena patients in order to define the occurrence of sinusitis in this entity. These studies, corroborated in part by nasal endoscopies, demonstrate a 70% ethmoid sinus involvement. The sphenoid, frontal, and maxillary sinuses are not usually involved. Other CT criteria of ozena are described.
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Shaw, Chi-kee Leslie, Robert B. Dymock, Allison Cowin, and Peter-John Wormald. "Effect of packing on nasal mucosa of sheep." Journal of Laryngology & Otology 114, no. 7 (2000): 506–9. http://dx.doi.org/10.1258/0022215001906246.

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The effects of packing with ribbon gauze and neuropatties on the nasal mucosa was assessed using sheep as an animal model. Fourteen sheep either underwent ribbon gauze or neuropattie nasal packing. Trauma to nasal mucosa caused by ribbon gauze and neuropatties was compared to mucosa on the lateral aspect of the middle turbinate which was not in contact with any packing. This tissue was used as a control. Ribbon gauze packing resulted in significant loss of 68 per cent of the ciliated surface of the mucosa when compared with the control group with a 15 per cent loss of ciliated surface (p < 0.005). Neuropattie packing also resulted in significant loss of 50 per cent of the ciliated surface of the mucosa when compared with the control group (p < 0.005). There was no significant difference in loss of ciliated mucosa in the specimens packed with ribbon gauze or neuropatties (p = 0.25).Nasal packing results in a significant mucosal injury with loss of cilia. This may influence the mucociliary clearance of the nose in the post-operative healing phase. Pre-operative nasal packing should be used circumspectly and if possible avoided.
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Dissertations / Theses on the topic "Mucosa nasal"

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Ahmed, Shahzada Khuram. "Angiogenesis in the nasal mucosa." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4032/.

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Nasal polyposis is a common disease affecting 2-4% of the general population. The aetiology and pathogenesis are far from clear. Recent publications have suggested up-regulation of several pro-angiogenic factors including VEGF. The aim of this study was to assess and quantify the degree of angiogenesis in nasal polyposis and to determine if angiogenesis was the driving force behind polyposis. We started by developing a novel triple stain to assess remodelling in the nasal mucosa. For the first time we were able to categorically refute the common belief of angiogenesis driven polyposis. We then carried out genomic studies and identified upregulation of genes controlling the cell cycle and apoptosis, suggesting cell turnover is an important part of the pathogenesis of nasal polyps. Our gene expression data was confirmed by TUNEL staining, indicating an increased level of apoptosis in nasal polyp tissue, counterbalancing the increased cell proliferation. Inflammatory genes are also upregulated, however the data collected so far cannot distinguish between different types of inflammatory response. We carried out proteomic studies using the lu minex system but this did not clarify the situation despite using matched samples that were used in the gene array. They highlight the protein differences occurring in the polyps themselves. We have shown chemoattractants for eosinophils & macrophages (which are found in polyps), and significantly in iNOS, which is novel.
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Nicola, Marina Lazzari. "Efeitos do tabagismo sobre o transporte mucociliar nasal, propriedades físicas do muco, pH do condensado do ar exalado, celularidade e citocinas de lavado nasal de jovens." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-29042014-104441/.

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O tabagismo está fortemente associado ao desenvolvimento da Doença Pulmonar Obstrutiva Crônica, porém poucos estudos que relatam alterações funcionais ou inflamatórias nas vias aéreas superiores em jovens são encontrados na literatura. Nosso objetivo foi investigar as alterações funcionais e inflamatórias nas vias aéreas superiores e inferiores em jovens tabagistas com idade igual ou inferior a 35 anos. Setenta e dois indivíduos participaram do estudo: 32 jovens não tabagistas (JNT) saudáveis (21±4 anos, 29 homens) e 40 jovens tabagistas subdivididos de acordo com a carga tabágica: menor que 2,5 anos-maço (< 2,5) (19±2 anos, 20 homens) e igual ou maior que 2,5 anos-maço (>= 2,5) (24 ± 5 anos, 17 homens e três mulheres). Foram avaliados os dados demográficos, os dados clínicos, os sintomas de desconforto das vias aéreas por meio do questionário SNOT-20, os volumes e capacidades pulmonares por meio do teste de função pulmonar, o transporte mucociliar nasal por meio do teste de tempo de trânsito da sacarina, a propriedade de superfície do muco nasal por meio do ângulo de contato, a inflamação na cavidade nasal por meio da contagem total e diferencial das células e citocinas em lavado nasal e a inflamação de vias aéreas inferiores por meio do pH do condensado do ar exalado. Observamos neste estudo que os jovens tabagistas >= 2,5 foram mais velhos comparados aos JNT e com os tabagistas < 2,5 (p < 0,01). Comparados com os JNT, os tabagistas >= 2,5 apresentaram maior índice de massa corporal (p=0,036), de frequência cardíaca (p=0,001) e de pressão arterial sistólica (p=0,036). Os tabagistas >= 2,5 apresentaram maior queixa sobre tosse (p=0,05) e secreção nasal escorrendo para a garganta (p=0,016) quando comparados com os JNT e tabagistas < 2,5. Não encontramos diferenças significativas na pontuação total do questionário SNOT-20 (p=0,140), nos valores do teste de função pulmonar e nos valores do ângulo de contato (p=0,803) entre os grupos. O tempo de trânsito da sacarina foi significativamente menor nos jovens tabagistas (5,9 ± 3,1 minutos) quando comparados aos JNT (7,7 ± 4,1 minutos, p=0,033). Na análise do lavado nasal encontramos maior número de células totais em tabagistas < 2,5 (48+-14) e tabagistas >= 2,5 (37+-25) comparados aos JNT (24+-12, p < 0,001). Encontramos também maior número de macrófagos (p=0,001), células ciliadas (p=0,008) e células caliciformes (p=0,004) nos tabagistas < 2,5 e tabagistas >= 2,5 quando comparados aos JNT, e maiores concentrações de mieloperoxidase nos tabagistas < 2,5 comparados aos tabagistas >= 2,5 (p=0,005). Os valores do pH do EBC foram menores em tabagistas >= 2,5 (7,65 ± 0,42) comparados com os tabagistas < 2,5 (7,83 ± 0,26) e com os JNT (7,90 ± 0,21, p=0,038). Por meio de análise de regressão linear, verificamos um efeito dose-dependente significativo do tabagismo sobre a redução dos valores do pH do EBC (r=-0,47, p < 0,001). Concluímos que o tabagismo em jovens tabagistas com idade igual ou inferior a 35 anos induz alterações do transporte mucociliar nasal, inflamação nasal e inflamação em vias aéreas inferiores e que essas alterações estão associadas à carga tabágica<br>Cigarette smoking is strongly associated with the development of Chronic Obstructive Pulmonary Disease, but few studies that reported functional or inflammatory changes in upper airway in young are found in the literature. We aimed to evaluate the effects of smoking on nasal mucociliary clearance, the mucus surface property and if there is inflammation in the nasal cavity and lower airways in young smokers aged less than 35 years. Of the 200 individuals contacted by telephone, 72 individuals entered in the study: 32 healthy young nonsmokers (YNS) (21 ± 4 years, 29 male) and 40 young smokers, subdivided according to smoking history: less than 2.5 pack-years (< 2.5) (19 ± 2 years, 20 male) and 2.5 pack-years or more ( >= 2.5) (24 ± 5 years, 17 male and three female). We assessed demographic data, clinical data, SNOT-20 questionnaire for symptoms of airway discomfort, the volumes and lung capacities by the pulmonary function test, the nasal mucociliary clearance using the saccharine transit test, the mucus surface property by the contact angle, the inflammation in the nasal cavity by the total and differential count of cells and cytokines in nasal lavage and inflammation of the lower airways by the exhaled breath condensate pH. In this study, we observed that young smokers >= 2.5 were older compared to YNS and smokers < 2.5 (p < 0.01). Compared with YNS, smokers >= 2.5 had higher body mass index (p=0.036), heart rate (p=0.001) and systolic blood pressure (p=.036). Smokers >= 2.5 complained more about cough (p = 0.05) and post-nasal discharge (p=0.016) when compared to YNS and smokers < 2.5. No significant differences were found in the total score of the SNOT-20 (p=0.140), in the pulmonary function test and mucus contact angle (p=0.803) between groups. The saccharine transit time was significantly lower in young smokers (5.9 ± 3.1 minutes) compared to YNS (7.7 ± 4.1 minutes, p=0.033). The number of total cells in nasal lavage fluid were greater in smokers < 2.5 (48±14) and smokers >= 2.5 (37 ± 25) compared to YNS (24 ± 12, p < 0.001). We also found greater number of macrophages (p=0.001), ciliated cells (p=0.008) and goblet cells (p = 0.004) in smokers < 2.5 and smokers >= 2.5 compared to YNS and a higher concentration of myeloperoxidase in smokers < 2.5 compared to smokers >= 2.5 (p=0.005). The EBC pH were lower in smokers >= 2.5 (7.65 ± 0.42) compared with smokers < 2.5 (7.83 ± 0.26) and with YNS (7.90 ± 0.21, p=0.038). Linear regression analysis confirmed a significant dose-dependent effect of smoking in decreasing EBC pH (r= -0.47, p < 0.001). We conclude that cigarette smoking induces changes in nasal mucociliary clearance, nasal inflammation and inflammation in the lower airways in young smokers aged less than 35 years and these changes are associated with smoking history
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Lindbom, John. "Phospholipase A₂ expression in the human nasal mucosa /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med864s.pdf.

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Harries, Helen Elizabeth. "Antibodies in the nasal mucosa : implications for allergic rhinitis." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582540.

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Allergic rhinitis is the outcome of an IgE-mediated allergic response in the nose. Previous studies of IgE produced by B-cells in the nasal mucosa of allergic rhinitis patients have shown an increased usage of the V H5 gene family, compared to the normal blood V H gene repertoire, which has been attributed to superantigen activity. Work reported in this thesis has been undertaken to investigate further how the antibody repertoire is shaped in allergic rhinitis. IgA-expressing B-cells in the nasal mucosa, from allergic and non-allergic donors, were also shown to have an increased usage of VH5 genes compared to the normal blood repertoire, suggesting the nasal environment favours VH5 expansion prior to allergy development. Somatic hypermutation patterns in VH5-Ca sequences were indicative of superantigen selection. FACS analysis of nasal turbinate cells with antibodies to S. aureus enterotoxins (SE) demonstrated TSST -1 + cells in allergic nasal tissue only. Incubation of nasal turbinate tissue with SEs appeared not to influence the VH-Cϵ repertoire in 24 hours, but SED + IL-4 may have inhibited VH-Cϵ transcription in allergic patients. Evidence of local antigen stimulation prior to SE incubation was evident in one of the patients; a large VH5 clonal family exhibiting extensive somatic hypermutation was present throughout the nasal turbinate. FACS sorting of Phl pl-binding plasma cells and single cell RT-PCR enabled cloning of a scFv fragment representing the V regions of a physiological, allergen-specific antibody expressed in allergic nasal mucosa. The scFv cloning protocol has also been applied to VH5 genes of interest, thus facilitating the study of their protein structure and function. This research increases the evidence for local, VH5-selecting, superantigen activity in the nasal mucosa and has developed a platform for further investigation of nasal antibody- superantigen / allergen interactions in allergic rhinitis.
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王敏 and Min Wang. "Control of vascular reactivity of the nasal circulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241153.

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Wang, Min. "Control of vascular reactivity of the nasal circulation /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22233222.

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Bai, Xue-Feng. "Modulation of experimental T cell autoimmunity in the nervous system with emphasis on nasal tolerance /." Stockholm, 1998. http://diss.kib.ki.se/1998ki/19980116baix.

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Dhamankar, Varsha Sudhir. "Cytochrome P450-mediated drug metabolizing activity in the nasal mucosa." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1585.

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Pre-systemic elimination by local enzymatic degradation can play a key role in limiting the bioavailability of intranasally administered drugs. Despite remarkable advancement in the characterization of the nasal biotransformative enzymes, knowledge of the role of the nasal mucosa in limiting bioavailability of therapeutic agents is still inadequate. The aim of this work was to evaluate the expression and substrate biotransformation activity of cytochrome P450 enzymes in the nasal mucosa using bovine olfactory and respiratory explants as in vitro models. Gene expression and localization of major CYP450 isoforms in the nasal mucosa were examined using RT-PCR and immunohistochemistry. The bovine nasal mucosa showed abundant expression of CYP2A6 and 3A4 genes whereas 1A1, 1A2, 2C9, and 2C19 isoforms were expressed at much lower levels. The CYP450 proteins were observed to be present in the epithelial layer and in submucosal glandular cells. The diffusion of melatonin, a CYP1A2 substrate, and the appearance of 6-hydroxymelatonin, its primary metabolite, across bovine olfactory and respiratory explants was measured, and nasal olfactory and respiratory microsomal preparations were used to quantify the kinetic parameters for melatonin 6-hydroxylation. Results indicated that bovine olfactory and respiratory CYP450 isoforms were metabolically active towards melatonin metabolism, and the respiratory mucosa demonstrated the greatest melatonin 6-hydroxylation activity. Numerical simulations were used to probe the effects of the relative magnitudes of the permeability coefficient and enzymatic parameters on net substrate mass transfer across nasal mucosal tissues. The simulations indicated that the concentration gradient of the drug coupled with its permeability coefficient were the most significant factors controlling the transport of drugs across the mucosal tissue. Enzymatic degradation decreased the flux of drugs across the mucosa and had the greatest impact on low permeability compounds. The results from these studies show that the bovine nasal mucosa possesses significant metabolic activity, and the flux of a metabolically labile substrate across the nasal mucosa can be significantly reduced by its enzymatic degradation within the tissue. Use of kinetic modeling to characterize of the extent of biotransformation in the nasal mucosa enables the identification of metabolism-limited bioavailability of intranasally administered drug compounds.
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Al, Khafaji Ammar Sahib Abdulameer. "Understanding the uptake of polystyrene nanoparticles by the nasal mucosa." Thesis, University of Iowa, 2016. https://ir.uiowa.edu/etd/2176.

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Nanoparticles have many proposed advantages for use in nasal drug delivery systems. Nanoparticles can improve uptake and efficacy and lower toxicity compared to the drug alone. In order to study the transport behavior of nanoparticles across nasal tissues, the uptake of non-biodegradable, fluorescently-labeled, carboxylate-modified polystyrene nanoparticles was measured. These 40 nm particles are spherical in shape and loaded with fluorescein, a fluorescent dye that can be measured spectrophotometrically, to determine the number of particles that entered the nasal tissues. In order to identify the pathways involved in the uptake of these particles, different pharmacologic inhibitors were also included in the nanoparticle transport studies. The results indicate that the nanoparticles enter the nasal tissues using several endocytosis mechanisms, namely, macropinocytosis, clathrin-mediated endocytosis, and caveolin-mediated endocytosis. These findings suggest that more than one endocytic pathway is involved in the uptake process in the nasal tissues, and these multiple pathways may help to increase the total nanoparticle uptake in the nasal tissues.
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Brooks, Zachary Edward. "Mechanical Stresses on Nasal Mucosa Using Nose-On-Chip Model." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1578492176817977.

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Books on the topic "Mucosa nasal"

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Drake-Lee, A. B. Nasal mast cells: A preliminary report on their ultrastructure. Headley Brothers, 1987.

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Eriksson, Catarina. Herbicide-induced toxicity in the nasal olfactory mucosa: Studies on Dichlobenil and Chlorthiamid. Sveriges Lantbruksuniversitet, 1995.

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Stubbs, Donald Orok. Dental characteristics associated with nasal obstruction due to nasal mucosal swelling. Faculty of Dentistry, University of Toronto], 1989.

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King, William Phillip. A cephalometric study of a sample of male children with chronic nasal mucosal swelling. s.n.], 1987.

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Division, Medicode (Firm) Med-Index, ed. Midface--sinus & nasal mucosa. Medicode, Med-Index Division, 1994.

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Medicode. Midface--Sinus & Nasal Mucosa (Coding Illustrated). Ingenix - Sta/Medicode, 1995.

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1948-, Hsieh Dean, ed. Drug permeation enhancement: Theory and applications. M. Dekker, 1994.

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Johnson, Nicholas J., and Judd E. Hollander. Management of cocaine poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0324.

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Cocaine is powerful central nervous system (CNS) stimulant derived from the coca plant. It affects the body via a number of mechanisms including blockade of fast sodium channels, increased catecholamine release, inhibition of catecholamine reuptake, and increased concentration of excitatory amino acid concentrations in the CNS. It is rapidly absorbed via the aerodigestive, respiratory, gastrointestinal, and genitourinary mucosa, and also may be injected. When injected intravenously or inhaled, cocaine is rapidly distributed throughout the body and CNS, with peak effects in 3–5 minutes. With nasal insufflation, absorption peaks in 20 minutes. Its half-life is approximately 1 hour. Common clinical manifestations include agitation, euphoria, tachycardia, hyperthermia, and hypertension. Chest pain is a common presenting complaint among cocaine users; 6% of these patients will have myocardial infarction. Other life-threatening sequelae include stroke, intracranial haemorrhage, seizures, dysrhythmias, and rhabdomyolysis. Clinical signs and symptoms, as well as severity of intoxication, should dictate the diagnostic evaluation and treatment of cocaine intoxicated patients. If the patient has chest pain, an ECG, chest radiograph, and measurement of cardiac biomarkers should be performed. A brief observation period may be useful in these patients. Many manifestations of cocaine intoxication, including agitation, hypertension, and chest pain, are effectively treated with benzodiazepines. Beta-blockers should be avoided in patients with suspected cocaine intoxication. Special attention should be paid to pregnant patients and those who present after ingesting packets filled with cocaine, as they may exhibit severe toxicity if these packets rupture.
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AWARE, Oregon, and Oregon. Office of Disease Prevention and Epidemiology., eds. Runny nose (green or yellow mucus) =: Descarga nasal (mucosidad verde o amarilla). Oregon AWARE, Oregon Dept. of Human Services, Office of Disease Prevention & Epidemiology, 2003.

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Reintjes, Staci, and Susie Peterson. Rhinosinusitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0012.

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Rhinosinusitis is inflammation of the nasal passages and paranasal sinuses, commonly caused by allergies or viral infection. Sinusitis occurs after the development of rhinitis or inflammation of the nasal passages. Rhinitis is most commonly caused by allergens, but it also can be to the result of an infectious or autoimmune process. For rhinitis to progress to rhinosinusitis, there must be obstruction within the ostiomeatal complex, which is the draining center for the maxillary, anterior ethmoid, and frontal sinuses. History and physical exam are more specific than imaging for diagnosis. Complications arising from sinusitis can cause extensive morbidity if not recognized early. The most common complication is periorbital cellulitis arising from ethmoidal sinusitis. Evaluate for severe complications in immunocompromised patients. Adjunctive therapies to relieve nasal obstruction include medications that decrease mucosal edema as well as increase clearance of congestion. Consider avoiding antibiotics if symptoms are of short duration and are consistent with viral sinusitis.
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Book chapters on the topic "Mucosa nasal"

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Kerns, William D. "Polypoid Adenoma, Nasal Mucosa, Rat." In Respiratory System. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96846-4_5.

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Bitter, Christoph, Katja Suter-Zimmermann, and Christian Surbera. "Nasal Drug Delivery in Humans." In Topical Applications and the Mucosa. KARGER, 2011. http://dx.doi.org/10.1159/000321044.

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Kerns, William D. "Squamous Cell Carcinoma, Nasal Mucosa, Rat." In Respiratory System. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-96846-4_7.

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Armstrong, Michelle, Shonagh Walker, Jenifer Mains, and Clive G. Wilson. "Drug Delivery Across the Nasal Mucosa." In Mucoadhesive Materials and Drug Delivery Systems. John Wiley & Sons, Ltd, 2014. http://dx.doi.org/10.1002/9781118794203.ch03.

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Krstić, Radivoj V. "Glandular Epithelia. Endoepithelial Gland of Human Nasal Mucosa." In General Histology of the Mammal. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70420-8_36.

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Béné, M. C., G. Faure, and M. Wayoff. "Specific Antibacterial Antibody-Producing Cells in Human Nasal Mucosa." In Recent Advances in Mucosal Immunology. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5344-7_42.

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Pelosi, P., C. Maremmani, and A. Muratorio. "Purification of an Odorant Binding Protein from Human Nasal Mucosa." In Chemosensory Information Processing. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75127-1_9.

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Spranz, E., B. Siegemund, J. Frevert, and H. E. Knoell. "Study on the Penetration of Tetanus Toxoid Through the Nasal Mucosa." In Archives of Toxicology. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-74936-0_59.

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Baumgarten, C. R., R. Schwarting, and G. Kunkel. "Localization of Glandular Kallikrein in Nasal Mucosa of Allergic and Nonallergic Individuals." In Advances in Experimental Medicine and Biology. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4615-9546-5_86.

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Mottura, A. Aldo. "Double-Guarded Osteotome for Internal Lateral Nasal Osteotomies to Prevent Mucosa Tearing." In Advanced Aesthetic Rhinoplasty. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-28053-5_29.

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Conference papers on the topic "Mucosa nasal"

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Jia, Yanlin, Gissela Lieber, Robbie L. McLeod, and John Anthes. "Corticosteroids Induce Vasoconstriction In Porcine Nasal Mucosa." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2778.

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Schmitz, P., and G. Strauß. "Effects of regeneration factors in nasal mucosa dysfunctions." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640904.

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Sooklal, Valmiki, Jesse McClure, Luke Hooper, and Michael Larson. "A laser device for fusion of nasal mucosa." In BiOS, edited by Nikiforos Kollias, Bernard Choi, Haishan Zeng, et al. SPIE, 2010. http://dx.doi.org/10.1117/12.843854.

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Zhu, Rui, Ryan Owen, Tracy Staton, et al. "Characterization of omalizumab partitioning in the nasal mucosa of patients." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa1657.

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Taylor, Donal J., Denis J. Doorly, and Robert C. Schroter. "Airflow in the Human Nasal Cavity: An Inter-Subject Comparison." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206459.

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The human nose is a remarkably complicated biological conduit that plays a significant, perpetual role in respiratory defense and olfaction. It is not a passive organ and has evolved to balance many conflicting requirements, while processing 10,000 litres of inspired air in a typical day [1]. The highly vascularised nasal mucosa heats and humidifies adjacent airflow, whilst the nasal mucosa collects nearly all particles over 5 μm diameter and approximately 50% of those between 2–4 μm [1]. Furthermore, the nasal airways house the olfactory apparatus, which enables humans to sense (smell) the external environment. The research presented here incorporates Computational Fluid Dynamics (CFD) in conjunction with experimental optical measurement techniques to resolve the patterns of flow within the nasal airways of two healthy subjects. This abstract details the experimental and computational methodologies used to simulate constant inspiration at a rate of 100 ml.s−1, which is representative of quiet restful breathing. The results presented focus on a comparison of the upper airway flow distributions in both subjects.
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Carson, Johnny L., Albert M. Collier, and Milan J. Hazucha. "Inflammation And Tight Junction Fragmentation In The Nasal Mucosa Of Active Smokers." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1743.

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Balas, Constantin J., P. N. Christodoulou, E. P. Prokopakis, and Emmanuel S. Helidonis. "Endoscopic machine vision system for blood-supply estimation of the nasal mucosa." In BiOS Europe '96, edited by Gregory B. Altshuler, Fausto Chiesa, Herbert J. Geschwind, et al. SPIE, 1996. http://dx.doi.org/10.1117/12.260714.

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Ducharme, Marie-Eve, Marie-Eve Boulay, Maire-Noelle Corriveau, Pierre Boisvert, Jamila Chakir, and Louis-Philippe Boulet. "Morphological Characteristics Of Nasal Polyp And Mucosa Epithelium Obtained From The Same Subjects." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3639.

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Ickrath, K., A. Scherzad, M. Steinke, and S. Hackenberg. "DNA-stability and -ability of regeneration of human nasal mucosa in culture models." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686889.

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Neto, João Augusto Dugim, Thainá Galvão Nunes, Nathali Da Câmara Hurtado, Jaqueline Ramos De Farias, and Renan Souto Terra. "TUMOR VENÉREO TRANSMISSÍVEL NASAL: RELATO DE CASO." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1885.

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Introdução: O Tumor Venéreo Transmissível (TVT) é uma neoplasia benigna de células redondas que podem afetar cães de ambos os sexos. Ocorre através do contato direto a partir da cópula ou lambedura, acometendo principalmente a mucosa genital externa desses animais, além das cavidades nasal ou oral, pele e reto. Objetivos: Relatar um caso de TVT de um cão, caracterizando a patologia com destaque no diagnóstico e tratamento. Material e métodos: Um cachorro da raça pitbull, fêmea, 2 anos, inteira, resgatada, foi atendida na Clínica Veterinária Tostes, Niterói/RJ, apresentando lesões na região da face, anorexia, mucosas hipocoradas, prostração, dispneia, epistaxe, descarga nasal, espirros e escore de condição corporal abaixo do padrão de normalidade. Foi realizado hemograma completo e citologia da região, observando-se anemia normocítica normocrômica, leucocitose, trombocitopenia, neutrofilia, monocitose e eosinopenia absolutas. Ademais, foram enviadas quatro lâminas de lesão em focinho para avalição citológica, certificando-se na análise: presença de células redondas com alta relação núcleo:citoplasma, anisocariose e anisocariose discretas, citoplasma moderadamente basofílico e núcleo de cromatina frouxa e 1 a 2 nucléolos, o que se constatou tratar de tumor venéreo transmissível. Resultados: No caso clínico apresentado, o animal por não ser castrado e não domiciliado, encontrava-se susceptível a apresentar a doença, pois essa enfermidade acomete mais frequentemente animais com estas características. O tratamento foi realizado com a aplicação endovenosa na dose de 0,025mg/kg de sulfato de vincristina, uma vez por semana, durante quatro semanas. Houve uma considerável diminuição do tamanho da lesão neoplásica do animal, com cessão da hemorragia, do ronco e dos espirros, além da melhora na respiração por redução do tecido tumoral presente na cavidade nasal. Conclusão: O protocolo terapêutico realizado obteve sucesso na regressão do tumor e o TVT apesar de ser uma neoplasia comumente benigna, pode apresentar histopatologicamente características malignas e possui tratamento. Os cães mais acometidos são os classificados como semi-domiciliados e comunitários, tendo em vista que esses animais possuem maior predisposição por estarem em contato com outros cães em situações ambientais e sanitárias desfavoráveis. Sendo assim, torna-se imprescindível que haja um controle populacional, minimizando as chances de propagação entre os mesmos.
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