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Dissertations / Theses on the topic 'Mucosal immune system'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 January 2023

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1

Etling, Michele R. "THE AGING MUCOSAL IMMUNE SYSTEM IN THE INTERLEUKIN-10-DEFICIENT MOUSE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1184295867.

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2

Ewing, Patricia A., and n/a. "Developmental profiles of mucosal immunity in pre-school children." University of Canberra. Human & Biomedical Sciences, 2000. http://erl.canberra.edu.au./public/adt-AUC20060707.154930.

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Previous studies of the ontogeny of the mucosal immune system have shown a significant increase in salivary Immunoglobulin A levels occurring at about five years of age. This study has monitored a group of 3 and 4 year old children during one year of attendance at Pre-School to examine whether such an increase could be linked to increased antigenic exposure associated with moving into a school like environment. Saliva samples were collected at regular intervals and analysed for immunoglobulin and total protein levels. Daily health records were maintained for each child, and a detailed social a

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3

Blazek, Alisa D. "A Simulated Altitude Device can Improve Endurance Performance without Mucosal Immune System Compromise." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267567607.

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4

Ucan, Uckun Sait. "T cells and cytokines in the lamina propria of the pig." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389234.

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5

Christoforidou, Zoe. "The role of gut microbiota in driving the development of the mucosal immune system." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689676.

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It is now accepted that gut microbiota are crucial for the development of the mucosal immune system. It has been suggested that differences in early life microbial colonisation may be associated with variable predisposition to allergic, auto immune, and inflammatory diseases. The exact underlying mechanisms are difficult to study in human infants, however, the similarities in physiology and nutritional requirements between pigs and humans suggest that piglets can be good models to elucidate the pathways involved. The aim of this PhD project was to investigate how differences in microbiota, ear

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6

Thompson, Fiona Marie. "Activation of the mucosal immune system and growth of the small intestine at weaning /." Title page, abstract and contents only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09pht4677.pdf.

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7

Harris, Cecilia. "Effect of environmental factors on the development of the mucosal immune system in the piglet." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419675.

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8

O’Meara, Connor Patrick. "The development of an effective vaccine against Chlamydia : utilisation of a non-toxic mucosal adjuvant to generate a protective mucosal response." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/61614/1/Connor_O%27Meara_Thesis.pdf.

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Chlamydia is responsible for a wide range of diseases with enormous global economic and health burden. As the majority of chlamydial infections are asymptomatic, a vaccine has greatest potential to reduce infection and disease prevalence. Protective immunity against Chlamydia requires the induction of a mucosal immune response, ideally, at the multiple sites in the body where an infection can be established. Mucosal immunity is most effectively stimulated by targeting vaccination to the epithelium, which is best accomplished by direct vaccine application to mucosal surfaces rather than by inje

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9

Law, Yuet Ching. "Specific Compartmentalization of IgA ASCs in Mouse Salivary Glands via Differential Expression of Chemokines and Chemokine Receptors." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1952.

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The mucosal system, which forms a barrier between internal organ systems and the external environment, is frequently exposed to pathogenic microorganisms. Immunoglobulin A (IgA) antibody secreting cells (ASCs) localize in the lamina propria, and produce IgA antibodies which help protect mucosal tissues. The concept of a common mucosal immune system in which IgA ASCs have the ability to populate any mucosal site has been proposed (1, 2). However, recent research has suggested that IgA ASCs primed in different mucosal sites might possess different sets of chemokine receptors, and therefore migra

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10

Zhang, Min Fen. "The role of milk transforming growth factor-[beta](TGF-[beta]) in the development of the infant gut and gut mucosal immune system." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phz51.pdf.

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In title, [beta] is represented by the Greek letter. Copies of author's previously published articles inserted. Errata pages pasted onto back end-paper. Bibliography: leaves 104-137. Studies milk TGF-[beta] and its receptors in the post-natal gut using a rat model to investigate a link between milk TGF-[beta] and the development of the infant gut and gut mucosal immune system. Finds maternal milk may be a major source of TGF-[beta] to the immature gut and may react with receptors on the cells of the mucosal immune system along the gastro-intestinal tract, modulating infant mucosal immune respo

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11

Stoicov, Calin. "Pathogenesis of the Helicobacter Induced Mucosal Disease: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/477.

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Helicobacter pylori causes chronic gastritis, peptic ulceration and gastric cancer. This bacterium is one of the most prevalent in the world, but affects mostly the populations with a lower socioeconomical status. While it causes gastric and duodenal ulcers in only 20% of infected patients, less then 1% will develop gastric adenocarcinoma. In fact, H. pylori is the most important risk factor in developing gastric cancer. Epidemiological studies have shown that 80% of gastric cancer patients are H. pylori positive. The outcome of the infection with this bacterium depends on bacterial factors, d

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12

Tyrer, Peter Charles, and n/a. "Targeting M-cells for oral vaccine delivery." University of Canberra. Health Sciences, 2004. http://erl.canberra.edu.au./public/adt-AUC20060427.122012.

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An in vitro model of the follicle-associated epithelia that overlie the Peyer's patches of the small intestine was developed and validated to examine the mechanisms of mucosal antigen sampling. This model displays many phenotypic and physiological characteristics of M cells including apical expression of [alpha]5[beta]l integrin and enhanced energy dependent participate transport. CD4+ T-cells were shown to be an important influence on the development of Mlike cells. The model was used to examine the M cell mediated uptake of several putative whole-cell killed bacterial vaccines. Greater numbe

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13

Stange, Jörg. "Studies on host-pathogen interactions at mucosal barrier surfaces using the murine intestinal parasite Eimeria falciformis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16716.

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Wir nutzten in dieser Studie den apikomplexen Parasiten Eimeria falciformis als Modell. Unsere Ergebnisse zeigen, dass das in infizierten Wildtypmäusen dominierende Zytokin IFN-γ für Immunschutz und für die Entwicklung der Darmpathologie entbehrlich war. E. falciformis-infizierte IFN-γR-/- and IFN-γ-/- Mäuse zeigten extremen Körpergewichtsverlust und starke Pathologie im Darm. Die Entwicklung des Parasiten in diesen Mäusen war überraschenderweise reduziert. Diese Beobachtungen gingen mit einer drastisch erhöhten Produktion von parasiten-spezifischem IL-17A und IL-22 durch CD4+ T Zellen einher.

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14

Smart, C. J. "The immune system of the human colonic mucosa : Functional and phenotypic analysis." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384715.

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15

Chen, Hong. "Activation and Role of Memory CD8 T Cells in Heterologous Antiviral Immunity and Immunopathology in the Lung: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/188.

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Each individual experiences many sequential infections throughout the lifetime. An increasing body of work indicates that prior exposure to unrelated pathogens can greatly alter the disease course during a later infection. This can be a consequence of a phenomenon known as heterologous immunity. Most viruses invade the host through the mucosa of a variety of organs and tissues. Using the intranasal mucosal route of infection, the thesis focused on studying modulation of lymphocytic choriomeningitis virus (LCMV)-specific memory CD8 T cells upon respiratory vaccinia virus (VV) infection and the

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16

Ho, Shu-Ying, and 何淑螢. "The Effect of Mushroom Polysaccharides on Intestinal Mucosal Immune System." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17428955621835487187.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>101<br>Mushroom polysaccharides are distinguished as important immunostimulant in animal body. Administrate glucan to animal inducing different isotype immunoglobulin secretion. Immunoglobulin A is the major antibody in the intestinal mucus, and transcytosis of IgA across epithelia is mediated by the poly-Ig receptor. Neutralization is important protection mechanism against antigen by IgA in gut. In the present study simulate acting intestinal mucosal immune system. Further to study the effects of mushroom polysaccharide on immunoglobulin A (IgA), immunoglobulin G (I

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17

Chege, Duncan Mwithiga. "Evaluating the Interaction of HIV and the Immune System in Mucosal Tissues." Thesis, 2013. http://hdl.handle.net/1807/35172.

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90% of Human Immunodeficiency Virus (HIV) infections are acquired across the genital or gastrointestinal mucosa, and infection leads to profound depletion of CD4+ lymphocytes. Antiretroviral therapy can restore blood CD4+ T cells. However, immune dysfunction and defects in mucosal antimicrobial defence persist. Some CD4+ T-subsets, particularly antimicrobial Th17 cells, show enhanced susceptibility to HIV infection and are also preferentially depleted in the course of HIV infection; the latter may allow microbial translocation into the bloodstream. Genital infections have been shown to have di

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18

Dunkley, Margaret Lorraine. "Factors affecting expression of antibody responses in the intestine." Thesis, 1990. http://hdl.handle.net/1959.13/1416102.

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Research Doctorate - Doctor of Philosophy (PhD)<br>The aim of the work presented in this thesis was to examine the role of T helper cells (Th) and other factors affecting the expression of antibody responses in the intestinal niucosa. The experiments described in this thesis demonstrate that in rats, a population of antigen specific Th cells appears in the gut mucosal tissues and PP are an enriched source of these cells if appropriately immunized. These cells have the capacity to migrate via the TDL and in addition to their role in induction sites may also have a role in effector sites such as

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19

Cummins, Adrian Gerard. "Interaction of the mucosal immune system with the epithelium of the small intestine / Adrian Gerard Cummins." 1989. http://hdl.handle.net/2440/18824.

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20

Cummins, Adrian Gerard. "Interaction of the mucosal immune system with the epithelium of the small intestine / Adrian Gerard Cummins." Thesis, 1989. http://hdl.handle.net/2440/18824.

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21

Thompson, Fiona Marie. "Activation of the mucosal immune system and growth of the small intestine at weaning / by Fiona Marie Thompson." Thesis, 1994. http://hdl.handle.net/2440/21494.

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Contains errata sheet in back pocket.<br>Bibliography: leaves 167-211.<br>xviii, 211, [8] leaves, [4] leaves of plates : ill. (some col.) ; 30 cm.<br>Explores the hypothesis that growth of the small intestine at weaning is promoted by an activated mucosal immune system in the gut. Tests by observing rats, guinea pigs and human infants.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1995?

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22

Gannon, Mark. "Immunomodulatory effects of dietary fibre supplementation: effects on cytokine and antibody production and lymphocyte population profiles." Thesis, 2009. http://hdl.handle.net/10155/37.

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Gastrointestinal microflora has been shown to have a bi-directional relationship with the host immune system. A variety of fermentable carbohydrate polymers largely pass through the small intestine, providing fermentable substrates for gut microflora. Dietary fibre supplementation may provide a strategy for manipulating the intestinal bacterial profile, changing the interaction with the mucosal immune system, thereby modulating the host immune system. We used a BBc rat animal model to evaluate the effects of oat bran and wheat bran dietary fibre on the immune system. Previous collaborative eff

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23

Fundová, Petra. "Slizniční imunita v nemocech horního respiračního traktu a autoimunitních onemocnění." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-353440.

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Mucosal immune system comprises not only the major compartment of the immune system but also important interface with the outer environment. It is responsible in maintaining an intricate balance with the danger and non-danger stimuli of the outer world by employing specific anatomical features and unique functional mechanisms. Mucosal immune system has been long understudied, perhaps due to the limited accessibility, and its biological importance is thus still underevaluated. However, it has become evident that it is important to study mucosal immune system not only in local mucosal affections

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24

Lee, Ying, and 李盈. "A study for Immuno-regulatory effect of herbal polysaccharides on mucosal system." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/96918714292348074284.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>95<br>The gut has a complex system to maintain the homeostasis in the battle of limiting inflammatory responses to commensal bacteria while retaining the ability to initiate protective adaptive immune responses to pathogens. Recently, some researches show that intestinal epithelial cells (IECs) may play key role in maintaining the homeostasis, for example, thymic stromal lymphopeitin (TSLP) produced by the IEC is capable of directing dendritic cells towards a Th2 response, and influencing the differentiation properties of monocytes into tissue macrophages. We’d like

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25

Syding, Linn. "The interaction between neuropeptides and the innate immune system in the nasal mucosa of healthy individuals and subjects with allergic rhinitis." Thesis, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-343031.

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Allergic rhinitis is a highly common disease prevalent worldwide. The symptoms include rhinorrhea, itchy eyes and swelling. It is driven by Immunoglobulin E and a type 2 T cell response resulting in inflammation in the upper airways. Allergic rhinitis is often under diagnosed and has no cure, only treatments with varying efficiency. The role of the peripheral nervous system has classically not been thought of as part of the immune system. Recent studies have however, been successful in demonstrating its involvement. One of its most studied mediators, substance P (SP), seems to have a role in p

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