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1

Farage, Miranda A., Christian Surber, and Peter Elsner. Topical applications and the mucosa. Basel: Karger, 2011.

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2

Filaretova, L. P. (Li︠u︡dmila Pavlovna) and Takeuchi K. (Koji), eds. Cell/tissue injury and cytoprotection/organoprotection in the gastrointestinal tract: Mechanisms, prevention, and treatment. Basel: Karger, 2012.

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3

Mucke, Hermann A. M. Transdermal & transmucosal therapeutics: New developments in drug delivery. Westborough, MA: D & MD Publications, 2004.

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4

Khutoryanskiy, Vitaliy V. Mucoadhesive materials and drug delivery systems. Chichester, West Sussex: John Wiley & Sons, Inc., 2014.

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5

C, Srivastava R. Surface activity in drug action. Amsterdam: Elsevier, 2005.

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6

Coșofreț, Vasile V. Pharmaceutical applications of membrane sensors. Boca Raton: CRC Press, 1992.

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7

1931-, Chambers P. L., Tuomisto Jouko, and Chambers C. M, eds. Toxic interfaces of neurones, smoke, and genes: Proceedings of the European Society of Toxicology Meeting held in Kuopio, June 16-19, 1985. Berlin: Springer-Verlag, 1986.

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8

1927-, Segawa Tomio, ed. Physiology and pharmacology of transmembrane signalling: Proceedings of the Uehara Memorial Foundation Symposium on the Mechanism of Transmembrane Signalling, Tokyo, Japan May 12-14, 1988. Amsterdam: Excerpta Medica, 1989.

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9

Alcohol and biological membranes. New York: Guilford Press, 1985.

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10

Khutoryanskiy, Vitaliy V. Mucoadhesive Materials and Drug Delivery Systems. Wiley & Sons, Incorporated, John, 2014.

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11

Sarmento, Bruno, and José das Neves. Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Springer, 2014.

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12

Sarmento, Bruno, and José das Neves. Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Springer, 2016.

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13

C, Aloia Roland, Curtain Cyril C, and Gordon Larry M, eds. Drug and anesthetic effects on membrane structure and function. New York: Wiley-Liss, 1991.

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14

Alois, Roland C., and Cyril C. Curtain. Drug and Anesthetic Effects on Membrane Structure and Function (Advances in Membrane Fluidity, Vol 5). John Wiley & Sons, 1991.

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15

Zimmer. Membrane Structure in Disease and Drug Therapy. CRC, 2000.

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16

Defense of mucosal surfaces: Pathogenesis, immunity and vaccines. Berlin: Springer, 1999.

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17

-P, Kraehenbuhl J., and Neutra M. R, eds. Defense of mucosal surfaces: Pathogenesis, immunity and vaccines. Berlin: Springer, 1999.

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18

(Editor), J. P. Kraehenbuhl, and M. R. Neutra (Editor), eds. Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines (Current Topics in Microbiology and Immunology). Springer-Verlag Telos, 1999.

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19

Membrane Structure in Disease and Drug Therapy. New York: Marcel Dekker, Inc., 2003.

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20

Gram-positive bacteria: Vaccine vehicles for mucosal immunization. Berlin: Springer, 1997.

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21

K, Majumder Hemanta, ed. Drug targets in kinetoplastid parasites. New York: Springer Science+Business Media, 2008.

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22

E, Steele Vernon, ed. Cellular and molecular targets for chemoprevention. Boca Raton, Fla: CRC Press, 1992.

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23

R.C. C. Srivastava (Editor) and A.N. N. Nagappa (Editor), eds. Surface Activity in Drug Action, Volume 21 (Studies in Interface Science). Elsevier Science, 2005.

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24

(Editor), A. J. Camm, Micha Tendera (Editor), and A. John Camm (Editor), eds. Heart Rate Slowing by If Current Inhibition (Advances in Cardiology). S. Karger AG (Switzerland), 2006.

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25

1935-, Strata Piergiorgio, Carbone E. 1948-, and European Neuroscience Association Meeting, eds. Mg²⁺ and excitable membranes. Berlin: Springer-Verlag, 1991.

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26

(Editor), Tomio Segawa, Makoto Endo (Editor), Michio Ui (Editor), and Kenzo Kurihara (Editor), eds. Physiology and Pharmacology of Transmembrane Signalling (International congress series). Elsevier, 1989.

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27

(Editor), T. Kenakin, and J. A. Angus (Editor), eds. The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems (Handbook of Experimental Pharmacology). Springer, 2000.

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28

R, Watson Ronald, ed. Alcohol and neurobiology: Receptors, membranes, and channels. Boca Raton: CRC Press, 1992.

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29

McCracken, Lindsay M., Mandy L. McCracken, and R. Adron Harris. Mechanisms of Action of Different Drugs of Abuse. Edited by Kenneth J. Sher. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199381678.013.010.

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Drugs of abuse represent a spectrum of chemically diverse compounds that are used via various routes of drug administration depending on the drug and its preparation. Although the exact molecular mechanisms by which these agents act to produce their intoxicating effects are not completely understood, many drugs of abuse are known to bind to specific neuronal membrane proteins that produce effects on cellular signaling and ultimately on behavior. With repeated administration of a drug, individuals often develop tolerance, and discontinuation of drug use following chronic administration typically results in withdrawal symptoms. This chapter describes the mechanism of action for the following classes of drugs of abuse: alcohol, cannabinoids, hallucinogens, inhalants, nicotine, opioids, sedative hypnotics, and stimulants. In addition, mechanisms of tolerance and withdrawal are discussed.
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