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Journal articles on the topic 'Mucous Membrane, drug effects'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Kotsyumbas, I. Ya, I. P. Patereha, V. I. Kushnir, S. Yа Martynyk, M. I. Zhyla, and М. М. Chudyak. "SETTING OF PARAMETERS OF ACUTE AND SUBACUTE TOXICITY OF THE POWDER BASED ON IODOFORM." Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology 22, no. 1 (2021): 103–9. http://dx.doi.org/10.36359/scivp.2021-22-1.11.

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The article presents the results of establishing the parameters of acute and subacute toxicity of the powder based on iodoform. Determination of acute toxicity parameters of the drug "Iodomin" were performed on 30 white mice 2-3 months of age, weighing 20-23 g and 30 white rats, aged 2-3 months, weighing 170-190 g. The drug was administered intragastrically, once, pre-dissolved in water. As a result of studies to determine acute toxicity by oral administration, it was found that, after administration of the drug in doses of 1000, 3000 and 5000 mg/kg, all animals remained alive. No change

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Vorobyeva, Natalya M., Irina P. Malaya, Vadim D. Zakiev, and Olga N. Tkacheva. "The possibility of using gastroenteroprotector rebamipide to improve the antithrombotic therapy safety." Clinical review for general practice 4, no. 6 (2023): 51–56. http://dx.doi.org/10.47407/kr2023.4.5.00271.

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Antithrombotic drugs (antiplatelet agents and anticoagulants) are widely used in cardiological practice for primary and secondary prevention of thrombotic/thromboembolic complications, however, the use of such drugs is associated with the increased risk of hemorrhagic complications, including gastrointestinal hemorrhage. Assessment by video capsule endoscopy has shown that the damaging effects of antithrombotic drugs are not confined to the upper gastrointestinal mucosa, but also expand to the lower gastrointestinal tract, affecting small and large intestine. That is why it is reasonable to us

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Podolyuk, M. V., L. R. Mateshuk-Vatseba, M. M. Mykhalevych, V. B. Fik, and I. P. Pasichnyuk. "SCANNING ELECTRONIC MICROSCOPY OF MUCOUS MEMBRANE OF THE UTERINE TUBE UNDER THE CONDITIONS OF PHYSIOLOGICAL NORM AND SIX-WEEK ADMINISTRATION OF OPIOID." Art of Medicine 23, no. 3 (2022): 94–98. http://dx.doi.org/10.21802/artm.2022.3.23.94.

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The toxic effects of opioids on the female reproductive system are important for theoretical and practical medicine, because excessive use of narcotic drugs causes pathological changes in organs and tissues and can predict the negative effects of "nalbuphine" on the female genitals. The excessive use of narcotic drugs, the prevalence of drug addiction, the use of opioids by modern medicine for therapeutic purposes, creates the need to carefully study the effects of opioids on the body of women, primarily the organs of the reproductive system, because despite the successes achieved in diagnosis

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4

Carvalho, Flávia Chiva, Marcos Luciano Bruschi, Raul Cesar Evangelista, and Maria Palmira Daflon Gremião. "Mucoadhesive drug delivery systems." Brazilian Journal of Pharmaceutical Sciences 46, no. 1 (2010): 1–17. http://dx.doi.org/10.1590/s1984-82502010000100002.

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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review

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5

Golubeva, M. I., М. V. Bidevkina, I. A. Bobrineva, et al. "EXPERIMENTAL STUDY OF THE TOXICITY AND HAZARD OF QUETIAPINE FUMARATE." Toxicological Review, no. 6 (January 5, 2021): 54–58. http://dx.doi.org/10.36946/0869-7922-2020-6-54-58.

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Quetiapine is a psychotropic drug, a dibenzothiazepine derivative and a representative of the class of neuroleptics (antipsychotic drugs) of a new subgroup – atypical antipsychotic drugs («second-generation antipsychotics»). Quetiapine fumarate belongs to the 3rd hazard class in terms of DL50 when administered in the stomach according to GOST 12.1.007-76 (DL50 1380-1680 mg/kg, mice and rats), has a local irritant effect: pronounced - on the mucous membrane of the eyes and moderately pronounced - on the skin. There are no signs of skin resorptive or cumulative effects of quetiapine fumarate. Wh

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6

Het, Patel*, Patel Jaini, Ghanshyam Patel Dr., Yadav Priyanka, and Divykant Patel Dr. "REVIEW-SUBLINGUAL ROUTE FOR SYSTEMIC DRUG DELIVERY." World Journal of Pharmaceutical Science and Research 2, no. 2 (2023): 45–57. https://doi.org/10.5281/zenodo.10894235.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in ger

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Kiryanova, V. V., V. A. Alexandrova, and A. V. Gordeichuk. "NARROWBAND OPTICAL EMISSION WAVELENGTH OF 540 NMIN THE COMPLEX TREATMENT OF CHILDREN WITH CHRONIC GASTRODUODENITIS." HERALD of North-Western State Medical University named after I.I. Mechnikov 9, no. 1 (2017): 102–6. http://dx.doi.org/10.17816/mechnikov201791102-106.

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Effects of low-intensity narrow-band optical irradiation wavelength of 540 nm on the clinical course of chronic gastroduodenitis in children, the mucous membrane of upper gastrointestinal tract morpho- logical status, the motor function of the gallbladder and esophagus. It was discovered that combina- tion therapy has a definite advantage over drug treatment on elimination of clinical manifestations and morphological and motor indicators of gastrointestinal tract dicfunction

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8

Mykhalevych Marta, Paltov Yevgen та Kryvko Yurii. "ПАТОМОРФОЛОГІЧНІ ЗМІНИ СТРУКТУР ПІДНИЖНЬОЩЕЛЕПНОЇ СЛИННОЇ ЗАЛОЗИ НАПРИКІНЦІ 6-го ТИЖНЯ ЕКСПЕРИМЕТАЛЬНОГО ОПІОЇДНОГО ВПЛИВУ". Science Review, № 3(30) (31 березня 2020): 3–6. http://dx.doi.org/10.31435/rsglobal_sr/31032020/6992.

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    The significant using of drugs and the prevalence of drug addiction in the last decades necessitates the study of the effects of opioids on the structural organization of organs and systems. The people with drug addiction syndrome have functional disorders of the salivary glands earlier than morphological changes in the mucous membrane of oral cavity.Reducing the amount of saliva and changing its composition lead to negative changes in the oral barrier function, salivary pH which is the main natural regulator of oral cavity homeostasis. This publication demonstrates

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Pawar, Poonam P., Hemant S. Ghorpade, and Bhavana A. Kokane. "Sublingual route for systemic drug delivery." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 340–43. http://dx.doi.org/10.22270/jddt.v8i6-s.2097.

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Drug delivery via the oral mucous membrane is considered to be a promising alternative to the oral route. Sublingual route is a rapid onset of action and better patient compliance than orally ingested tablets. Sublingual literally meaning is “under the tongue”, administrating substance via mouth in such a way that the substance is rapidly absorbed via blood vessels under tongue. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first‐pass metabolic processes giving acceptable bioavailability. Sublingual technology is convenient for dosing in geriatric, pedi

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Kishimoto, Hisanao, Caroline Ridley, Katsuhisa Inoue, and David J. Thornton. "Assessment of polymeric mucin–drug interactions." PLOS ONE 19, no. 6 (2024): e0306058. http://dx.doi.org/10.1371/journal.pone.0306058.

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Mucosal-delivered drugs have to pass through the mucus layer before absorption through the epithelial cell membrane. Although there has been increasing interest in polymeric mucins, a major structural component of mucus, potentially acting as important physiological regulators of mucosal drug absorption, there are no reports that have systematically evaluated the interaction between mucins and drugs. In this study, we assessed the potential interaction between human polymeric mucins (MUC2, MUC5B, and MUC5AC) and various drugs with different chemical profiles by simple centrifugal method and fl

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Villa, Afonso Luiz, Ceneviva Reginaldo, Fernanda Viaro, Fernando Ramalho, Antonio Dorival Campos, and Paulo Roberto B. Evora. "The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug." Arquivos de Gastroenterologia 43, no. 3 (2006): 233–37. http://dx.doi.org/10.1590/s0004-28032006000300015.

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BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AI

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More, Mayuri, Prakash Jadhav, Ashish Bhongale, Atish Velhal, Vivek Kumar Redasani, and Nishigandha Naikawadi. "An Overview on Antifungal Drug Therapy." Asian Journal of Pharmaceutical Research and Development 11, no. 3 (2023): 194–200. http://dx.doi.org/10.22270/ajprd.v11i3.1270.

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Nowadays, the majority of fungal infections, including candidiasis, can cause anything from a minor mucous membrane infection to fatal systemic mycoses. Due to the most rapid increase in populations with impaired hosts, such as those with HIV/AIDS, organ transplant recipients, and chemotherapy patients, candida infections present a serious clinical challenge internationally. In addition, a dramatic rise in the number of elderly people who are vulnerable to fungal infections is anticipated in the next decades. Due to the eukaryotic structure of the cells, developing antifungal medications for t

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SV, Patil, Sutar SB, Yesare SA, and Behera AL. "Innovations and Applications in Bioadhesive-Based Pulsatile Drug Delivery Systems." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 955–60. https://doi.org/10.25258/ijddt.14.4.69.

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Recent technological advancements have significantly increased the demand for Novel Drug Delivery Systems (NDDS) in the pharmaceutical industry. Controlled Drug Delivery Systems (CDDS) are a notable example, maintaining consistent drug levels and enhancing bioavailability. However, oral dosage forms can face challenges with fluctuating plasma levels and bioavailability due to variable gastric emptying rates, particularly affecting drugs absorbed in the upper gastrointestinal tract. To address this, Gastroretentive Formulations (GRDFs) have been created to extend gastric retention and improve d

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Szweda, M., J. Szarek, K. Dublan, M. Gesek, and T. Mecik-Kronenberg. "Effect of selected non-steroidal anti-inflammatory drugs on the pathomorphology of the mucous membrane of the canine colon." Veterinární Medicína 58, No. 8 (2013): 430–36. http://dx.doi.org/10.17221/6983-vetmed.

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Non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for the management of chronic pain caused by inflammatory joint disease in dogs. Although effective at relieving pain and inflammation, NSAIDs are associated with a significant risk of serious gastrointestinal side effects. The present study was therefore designed to investigate the effects of carprofen as a poorly-selective COX (cyclooxygenase) inhibitor and robenacoxib as a selective COX-2 inhibitor on the colon mucosa. A biopsy of the gastrointestinal tract was performed before treatment and on the last day of treatment

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15

Ryazantsev, S. V. "Topical therapy algorithm in the treatment of tonsillopharyngitis." Russian Otorhinolaryngology 22, no. 4 (2023): 133–39. http://dx.doi.org/10.18692/1810-4800-2023-4-133-139.

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Acute tonsillopharyngitis (OTP) is an acute infectious inflammation of the mucous membrane and lymphadenoid structures of the oropharynx of viral, bacterial, fungal etiology, is one of the most common diseases in the outpatient practice of a doctor. Due to the frequent irrational use of systemic antibacterial drugs along with the growth of resistance of bacterial pathogens to them, drugs for local therapy attract special attention. In accordance with the clinical guidelines for the treatment of OTP with severe sore throat, taking into account the need, tolerability and age of the patient, the

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Sachuk, R. M., S. V. Zhyhalyuk, I. M. Lukyanik, M. S. Mandyhra, Ya S. Stravsky, and O. A. Katsaraba. "Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”." Veterinary Medicine: inter-departmental subject scientific collection, no. 105 (August 7, 2019): 54–58. http://dx.doi.org/10.36016/vm-2019-105-10.

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The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mic

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Nagorna, L. V. "ФАРМАКО–ТОКСИКОЛОГІЧНА ОЦІНКА ПРЕПАРАТУ «ЦИФЛУР»". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 18, № 3(71) (2016): 214–17. http://dx.doi.org/10.15421/nvlvet7149.

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The results of pharmaco–toxicological evaluation insectoacaricid preparation «Tsiflur», in particular the study of locally irritating effect of the drug on the skin and mucous membranes of rabbits eyes. The preparation «Tsiflur» – representative of synth pyrethroids, in its composition has the active ingredient cyfluthrin, production NPF «Brovafarma». According to the manufacturer's instructions, the preparation recommended for the control of flying midges and other representatives akaroentomofauny that have veterinary importance. The tool is a clear oily solution of a yellowish color.Experime

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Mohammed, Azhar Hussain, GB Kamali, Mohammed Hussaini Syed, Jadhav Kiran, and Naik Vinod. "Herbal medicine induced Steven Johnson Syndrome: A Case Report." American Journal of PharmTech Research 13, no. 1 (2023): 82–88. https://doi.org/10.5281/zenodo.7628227.

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ABSTRACT Steven Johnson syndrome is a severe and potentially lethal disease due to an immune-complex-mediated hypersensitivity reaction involving mucous membranes and skin. Steven Johnson syndrome and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by the detachment of skin and mucous membranes. It has been a common belief that herbal drugs do not cause such as much as side effects and toxicities as pure chemicals. Recently, SJS associated with herbal medicine has been reported. This paper aims to report a case of SJS marked with skin manifestations following the u

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Szumny, Dorota, and Marta Misiuk-Hojło. "Dexpanthenol in the treatment of corneal disorders and injuries." OphthaTherapy. Therapies in Ophthalmology 9, no. 3 (2022): 195–99. http://dx.doi.org/10.24292/01.ot.300922.4.

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Dexpanthenol – a precursor to vitamin B5 – is a compound of natural origin that has a long-known beneficial effect on skin and mucous membrane hydration and epithelial healing. Its anti-inflammatory activity is also used in treatment. Its effects on superficial tissues have been observed in numerous in vitro and in vivo studies, but the exact mechanism of action has not yet been understood. In ophthalmology, dexpanthenol is a well-known and widely used drug in patients with acute and chronic diseases of the ocular surface, as well as for treating the sequelae of corneal injuries.

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S.B., Nishitha, S. Anuradha, and Augustine Mary. "Patterns of Drug Use and Adverse Drug Reactions in Patients with Autoimmune Bullous Disease (AIBD)." International Journal of Current Pharmaceutical Review and Research 14, no. 04 (2022): 97–105. https://doi.org/10.5281/zenodo.12657659.

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Background: AIBD is an autoimmune dermatological disorder affecting predominantly theskin and mucous membrane. Though newer biologic Rituximab has been introduced in thelast decade, systemic corticosteroids form the mainstay of the treatment. Comprehensivestudies reporting drug use pattern, adverse effects and costs involved with treatment havebeen few in India.Objectives: To evaluate the pharmacotherapy its adverse effects of AIBD, and costs incurredfor treatment.Methods and Materials: Prospective observational study that enrolled adults with AIBD, whowere followed up at 1 and 3 months. Data

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Dutra, Luíza Bastos, and Gláucia de Ávila Oliveira. "RELAÇÃO DA TERAPIA MEDICAMENTOSA COM OS EFEITOS ADVERSOS NA CAVIDADE BUCAL: UMA REVISÃO INTEGRATIVA." Revista ft 28, no. 140 (2024): 40–41. http://dx.doi.org/10.69849/revistaft/pa10202411221940.

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OBJECTIVES: To list the main oral manifestations associated with the adverse effects of drugs commonly prescribed in the treatment of systemic conditions. MATERIALS AND METHODS: 24 articles accessed through the Pubmed database published between 2014-2024, in English, Spanish and Portuguese, were evaluated after searching with the keywords “Drug Therapy” AND “Drug-Related Side Effects and Adverse Reactions” AND “Oral Manifestations”. RESULTS: The results of this study, focusing on medications and their corresponding oral manifestations of adverse reactions, were summarized in Table 1, highlight

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Drozdov, V. N., Yu V. Meshcheryakov, S. Yu Serebrova, and E. V. Shikh. "NSAID-induced damage to the gastrointestinal tract: new opportunities for the prevention of gastro- and enteropathies." Medical Council, no. 21 (January 28, 2020): 166–74. http://dx.doi.org/10.21518/2079-701x-2019-21-166-174.

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Nonsteroidal anti-inflammatory drug is one of the most commonly prescribed drugs for the treatment of inflammatory and pain syndromes in the clinical practice of doctors of various specialties. The popularity of this pharmacological group is increasing due to over-the-counter dispensing condition, but at the same time, the significance of issues of likelihood, prevention and treatment of severe adverse drug reactions during intake that is controlled and uncontrolled by medical personnel is increasing. This review is devoted to the issue of non-steroidal anti-inflammatory drug-induced damage to

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Ganesh, C. Patil, S. Jain Akash, R. Patil Divakar., Z. Shaikh Azam, R. Shaikh Sameer, and Sunil P. Pawar Dr. "An Examination of the Mucoadhesive Drug Distribution System." Journal of Advances in Drug Discovery and Development 2, no. 1 (2024): 27–36. https://doi.org/10.5281/zenodo.11379738.

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<em>By creating innovative drug delivery methods, like the mucoadhesive system, medication effects can be improved. </em><em>Mucoadhesive drug delivery techniques interact with the mucus layer covering the mucosal surfaces. </em><em>Mucin molecules and the epithelium surface, prolonging the duration the dose form spends at the absorption site. Drugs that have a local effect or that are best absorbed in the gastrointestinal tract (GIT) need to stay there for a longer period of time.There are now five theories that explain mucoadhesion: electronic, adsorption, wetting, diffusion, and fracture. T

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Marchenkova, L. A., and E. V. Makarova. "Oral bisphosphonates as the therapy of choice in patients with moderate risk of fractures." Meditsinskiy sovet = Medical Council, no. 7 (May 29, 2020): 122–28. http://dx.doi.org/10.21518/2079-701x-2020-7-122-128.

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Nowadays clinicians have access to high-quality diagnostic algorithms to determine the risk of fractures and the need for treatment, as well as the ability to choose the most advanced drug therapy that will be the most suitable, comfortable and safe for the patient with osteoporosis. This algorithm for the selection of therapy is based on an assessment of the fracture risk, which is determined by the presence and severity of low-energy fractures, the level of bone mineral density (BMD), and the 10-year probability of fractures. Patients with a moderate risk of osteoporotic fractures are the mo

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Pomortseva, I. V. "Pharmacological aspects of decongestants use in the treatment of patients with inflammatory diseases of the nose and paranasal sinuses in pediatric practice." Meditsinskiy sovet = Medical Council, no. 7 (May 24, 2025): 100–108. https://doi.org/10.21518/ms2025-162.

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Acute upper respiratory infections are common among children and are often accompanied by inflammation of the mucous membrane of the nose and paranasal sinuses. Vasoconstrictive decongestants are one of the key methods of symptomatic therapy in inflammatory ear, throat, and nose (ENT) diseases. This research explores the pharmacology of decongestants, their classification, mechanism of action, features of administration in pediatric practice, and potential side effects. The safety of drugs in terms of their chemical structure, age groups and duration of use are given special attention. The art

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S.B., Nishitha, S. Anuradha, and Augustine Mary. "Patterns of Drug Use and Adverse Drug Reactions in Patients with Autoimmune Bullous Disease (AIBD)." International Journal of Current Pharmaceutical Review and Research 14, no. 4 (2022): 97–105. https://doi.org/10.5281/zenodo.7612880.

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<strong>Background:</strong>  AIBD is an autoimmune dermatological disorder affecting predominantly the skin and mucous membrane. Though newer biologic Rituximab has been introduced in the last decade, systemic corticosteroids form the mainstay of the treatment. Comprehensive studies reporting drug use pattern, adverse effects and costs involved with treatment have been few in India. <strong>Objectives:</strong> To evaluate the pharmacotherapy its adverse effects of AIBD, and costs incurred for treatment. Methods and Materials: Prospective observational study that enrolled adults with AIB

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Kvolik, Slavica. "Diclofenac: The impact of different routes of administration on the efficiency of the drug." Galenika Medical Journal 3, no. 9 (2024): 36–40. http://dx.doi.org/10.5937/galmed2411034k.

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Diclofenac is a non-steroidal anti-inflammatory drug, which has been on the market for many years. During its clinical use, it has been confirmed as an effective analgesic for the treatment of acute post-traumatic pain, postoperative pain, and chronic pain conditions such as chronic back pain and rheumatoid arthritis. In addition to its analgesic effects, it has also been confirmed as an anti-inflammatory drug and antipyretic. Diclofenac is available on the market in various formulations that allow for its systemic use intravenously, intramuscularly, orally, rectally, or topically on the skin

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Sachuk, R. M. "Determination of toxicity indicators and assessment of the sensibilizing action of the preparation for the external use ‘Ointment for wounds’." Journal for Veterinary Medicine, Biotechnology and Biosafety 5, no. 3 (2019): 22–26. http://dx.doi.org/10.36016/jvmbbs-2019-5-3-5.

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The purpose of the work is a determination of toxicity and sensitizing effects of a new external preparation ‘Ointment for wounds’, based on the essential oils of Siberian pine, eucalypt, tea-tree, cedar, clove, and oil solution of chlorophyllite. The experimental study was performed on rats weighing 160–190 g, 2–3 months of age and mice weighing 18–21 g, 3 months of age. At the stages of preclinical study, it was determined acute and subacute effects of the drug, when administrated on the skin and directly into the stomach of experimental animals. The skin-irritant effect of the phytopreparat

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Srivastava, Bhavana, Reena Bhardwaj, Renu Khanchandani, Zafar Masood Ansari, and Gunjita Belwal. "Rifampicin- and allopurinol-induced Stevens-Johnson syndrome: A case series." Indian Journal of Physiology and Pharmacology 65 (June 2, 2021): 51–54. http://dx.doi.org/10.25259/ijpp_386_2020.

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Stevens-Johnson syndrome (SJS) is a rare, serious disorder and may be life threatening affecting mainly mucocutaneous tissues. It is a type of generalised, multisystemic hypersensitivity reaction directly linked to the drug intake. It is one of the few serious adverse effects of drugs involving skin and mucous membranes which are characterised by rash, bullae and blisters spread on skin, mucous membranes, swelling with erosive lesions on lips and face and hyperpigmentation. Normally, SJS is a self-resolving condition but it has potential to be converted into life-threatening disease. Here, we

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Bharti, Rakesh. "Dasatinib induced penile and scrotal edema a case report." Our Dermatology Online 14, e (2023): e7-e7. http://dx.doi.org/10.7241/ourd.2023e.7.

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Dermatologist’s opinion is often sought for various types of drug reactions/side effects-specially, if the effects are on skin, mucous membranes or genitals. Updating their knowledge about newer molecules (drugs) and their side effects,thus become a necessity. Dasatinib is a new USFD approved Tyrosine kinase inhibitor for the treatment of those Chronic Myeloid Leukemias patients who cannot tolerate Imatinib or are resistant to imatinib. Dasatinib can cause fluid retention in some patients,which can lead to peripheral edema and pleural effusion. Penile and scrotal edema are unusual manifestatio

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Hladkykh, F. V. "Macroscopic assessment of protective effect of cryopreserved placenta extract in ibuprofen-induced gastroenterocolonopathy." GASTROENTEROLOGY 55, no. 3 (2022): 172–79. http://dx.doi.org/10.22141/2308-2097.55.3.2021.241587.

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Background. Over-the-counter use of nonsteroidal anti-inflammatory drugs leads to their uncontrolled consumption among the population, which in some cases makes it impossible to prevent and timely detect adverse drug effects, and their effectiveness does not always satisfy clinicians. The purpose was to characterize the cytoprotective properties of cryopreserved placenta extract according to the condition of the mucous membrane of the proximal (esophagus and stomach) and distal (small and large intestine) parts of the gastrointestinal tract on the model of ibuprofen-induced esophagogastroenter

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Fitrya, Fitrya, Annisa Amriani, Rennie Puspa Novita, and Fadila Kurnia. "Gastroprotective Effects of Dendropthoe pentandra Leaf Ethanol Extract on Peptic Ulcer Animal Models." Science and Technology Indonesia 8, no. 3 (2023): 382–87. http://dx.doi.org/10.26554/sti.2023.8.3.382-387.

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Dendrophthoe pentandra (Loranthaceae) is a semi-parasitic plant with several diverse metabolites and biological activities and is widely used in traditional medicine. This study aims to evaluate the gastroprotective effectiveness of the ethanol extract of D. pentandra leaves in animals induced by an acute peptic ulcer with absolute ethanol. The gastroprotective effect of the extract (100, 250 and 500 mg/kg doses) was evaluated through ulcer index parameters, physicochemical properties of gastric fluid, and histopathological analysis. The study results of the study showed that the ethanol extra

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Pachevska, Alisa V., Alina V. Biloshitska, and Valery M. Istoshyn. "Effects of Prophylactic Use of a Decoction of Blueberry Leaves in Modeling the Lesion of the Gastrointestinal Tract by Non-Steroidal Anti-Inflammatory Drugs." Acta Balneologica 62, no. 4 (2020): 239–44. http://dx.doi.org/10.36740/abal202004107.

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Introduction: Today there is a continuing search for an effective, affordable remedy that can be used to treat and prevent diseases of periodontal, stomach and duodenum during the use non-steroidal anti-inflammatory drugs ( NSAIDs ). Aim: To study the protective effect of phytopreparation (decoction of blueberry leaves) on an experimental model of gastric ulcer and periodontitis. Material and Methods: The study was performed on 30 rats, which were evenly divided into three groups: 1 – control animals, 2 – animals that were modeled with non-steroid gastric ulcer and periodontitis (7 mg/kg diclo

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Galasso, M. "NAPHAZOLINE ABUSE: A RARE CASE OF MINOCA." European Heart Journal Supplements 26, Supplement_2 (2024): ii198. http://dx.doi.org/10.1093/eurheartjsupp/suae036.474.

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Abstract Nasal vasoconstrictors are some of the most widely used over–the–counter drugs, considered by many consumers as relatively safe with few significant side effects. At recommended dosage, the drug produces local vasoconstriction in nasal mucous membranes. However, the use of such drugs has been linked to cardiovascular adverse effects, including hypertension, arrhythmias, prolongation of the QT interval, and angina pectoris. The various cardiovascular adverse effects may occur with both oral and nasal administration and after a single dose or prolonged treatment, without dose–effect and

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Rana, Shubham, Prashant Kumar Gupta, and Sudhansu Ranjan Swain. "Buccal Drug Delivery System: A Comprehensive Review." International Journal of Pharmaceutical Sciences and Medicine 9, no. 6 (2024): 104–18. http://dx.doi.org/10.47760/ijpsm.2024.v09i06.010.

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The buccal area of the oral cavity is an ideal target for administering the desired medicine, as it helps overcome the limitations of conventional drug administration. The occurrence of presystemic metabolism and drug depletion in the digestive tract can be avoided by administering the medicine orally. The buccal drug delivery system is an innovative technique of delivering drugs that offers several advantages, particularly in terms of oral administration. The duration of placing the medicinal formulations at the desired site could be prolonged. The structures directly come into contact with b

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Oltarzhevskaya, N. D., M. A. Korovina, U. A. Barsukov, A. G. Malikhov, D. V. Kuzmichev, and I. Sh Tataev. "DEVELOPMENT AND APPLICATION OF THERAPEUTIC GELS “KOLEGEL” FOR TARGETED DELIVERY OF DRUGS IN TREATMENT OF RECTAL CANCER." Russian Journal of Biotherapy 14, no. 3 (2015): 63–68. http://dx.doi.org/10.17650/1726-9784-2015-14-3-63-68.

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A large part of basic research including medical area studies transportation and delivery of drugs directly to the organs, tissues and cells. This interest has been caused by many reasons, and above all, by huge medical and economic benefits of directed transport, reduced side effects and significant reduction of therapeutic drug doses. LLC «KOLETEX» designs and manufactures therapeutic gels for targeted drug delivery - gels «Kolegel» with various drugs, with the aim to improve effectiveness of radiotherapy and prevent radiation reactions. These gels are widely used in major oncology clinics,

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Gómez-Segura, Lidia, Alexander Parra, Ana C. Calpena, Álvaro Gimeno, and Antonio Boix-Montañes. "Carprofen Permeation Test through Porcine Ex Vivo Mucous Membranes and Ophthalmic Tissues for Tolerability Assessments: Validation and Histological Study." Veterinary Sciences 7, no. 4 (2020): 152. http://dx.doi.org/10.3390/vetsci7040152.

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Carprofen (CP), a non-steroidal anti-inflammatory drug (NSAID), is profusely used in veterinary medicine for its analgesic and anti-inflammatory activity. Some undesirable effects are associated with its systemic administration. Alternative local routes are especially useful to facilitate its administration in animals. The main aim of this paper is to validate the suitability of ex vivo permeation experiments of CP with porcine mucous membranes (buccal, sublingual and vaginal) and ophthalmic tissues (cornea, sclera and conjunctiva) intended to be representative of naïve in vivo conditions. Chr

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Yaskiv, G.I. "Primary toxicological evaluation of nitroxoline on laboratory animals." Medicni perspektivi 22, no. 1 (2017): 111–14. https://doi.org/10.26641/2307-0404.2017.1.101440.

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Nitroxoline is an effective antibacterial agent that is industrially produced by chemical and pharmaceutical enterprises in Ukraine. Parameters of its toxicity are determined under conditions of acute and subchronic toxicological experiments on 3 kinds of laboratory animals, by administering the drug orally and by application onto the skin and mucous membranes. The duration of acute experiment was 14 days, subchronical - 24 days. It was found that median lethal dose (DL<sub>50</sub>) for white female rats is 980 (852:1127) mg/kg, of white male rats – 835 mg/kg, white male mice&

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Starostina, L. S. "Treatment of respiratory diseases with inhalation patches." Medical Council, no. 11 (July 18, 2019): 89–94. http://dx.doi.org/10.21518/2079-701x-2019-11-89-94.

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The high incidence of respiratory infections at an early age requires constant attention of doctors of various specialties. It should be born in mind that the development of the respiratory tract in young children has unique features, and that different drugs can have different effects on the mucous membrane and ciliated epithelium. Also take into account the possibility of using different ways drugs can be administered to prevent and treat respiratory infections with due account for the age of the child, the effectiveness of action and adverse events risk reduction.

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Porfiryeva, N. N., I. I. Semina, R. I. Moustafine, and V. V. Khutoryanskiy. "Intranasal Administration as a Route to Deliver Drugs to the Brain (Review)." Drug development & registration 10, no. 4 (2021): 117–27. http://dx.doi.org/10.33380/2305-2066-2021-10-4-117-127.

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Introduction. Intranasal drug delivery from nose-to-brain is one of the promising approaches for the treatment of brain diseases including neurodegenerative diseases, stroke, brain tumors, etc.Text. Delivery of drugs through the nose has a number of advantages, including the rapid onset of a pharmacological effect, the ability to bypass the blood-brain barrier, avoidance of some side effects and fast and non-invasive route of administration. However, the significant disadvantages of this route are rapid elimination of the drug from the surface of the mucosal membrane, poor penetration of the d

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Kandolf-Sekulović, Lidija. "An update on diagnosis and treatment of toxic epidermal necrolysis / Novine u dijagnostici i lečenju toksične epidermalne nekrolize." Serbian Journal of Dermatology and Venerology 3, no. 2 (2011): 53–64. http://dx.doi.org/10.2478/v10249-011-0037-5.

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Abstract Toxic epidermal necrolysis is an idiosyncratic drug reaction which manifests with extensive epidermal detachment due to the massive keratinocyte apoptosis, mucous membrane involvement, and potentially lethal outcome. It is caused by adverse reactions to drugs, mostly idiosyncratic, unpredictable and independent of the applied dose, which develops 7-21 days after initiation of the drug, and is most commonly caused by the following drugs: sulfonamides, allopurinol, carbamazepine, phenobarbitone, phenytoin and oxycam group of nonsteroidal anti-inflammatory drugs. The treatment outcome de

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Morokhina, S. L., R. N. Alyautdin, D. A. Kaperko, E. V. Shubnikova, I. I. Snegireva, and Yu A. Smirnova. "Adverse Reactions of Drugs Containing Valeriana and Corvalol: Analysis of Spontaneous Reporting." Safety and Risk of Pharmacotherapy 6, no. 4 (2018): 162–73. http://dx.doi.org/10.30895/2312-7821-2018-6-4-162-173.

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Abstract. Valerianа officinalis rhizomes whis roots, monocomponent and complex herbal drugs based on Valerianа officinalis, and the drug Corvalol containing chemically synthesized α-bromizovalerianic acid ethyl ester (ethyl bromovalerianate) are OTC drugs and are widely used. At the same time, in the database of drug adverse effects «Pharmacovigilance» AIS Roszdravnadzor from 2009 to 2018, 147 spontaneous reports of adverse reactions were registered when taking Valeriana rhizomes whis roots and Corvalol. The aim of the study was the analisis of spontaneous reporting about adverse reactions whe

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Малгожата, Зыгмунт, and Сапа Яцек. "Progesterone – a new look at an old drug." REPRODUCTIVE ENDOCRINOLOGY, no. 33 (February 24, 2017): 17–25. https://doi.org/10.18370/2309-4117.2017.33.17-25.

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On the basis of the literature the role of progesterone in contemporary medicine was described, having regard to different routes of administration. Review of the available literature on the role of progesterone in modern obstetric practice says that after 80 years of application of this steroid, it has the potential to continue to be used in clinical practice. The replacement of exogenous progesterone is a recognized treatment for a hormonal deficiency, which occurs in the II phase of the menstrual cycle and during pregnancy endangered, and his future in gynecology and obstetrics is not under

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Ryazantsev, S. V., G. P. Zakharova, and N. I. Ivanov. "Drug therapy possibilities for various forms of chronic rhinitis accompanied by dry nose syndrome." Meditsinskiy sovet = Medical Council, no. 1 (February 26, 2024): 123–32. http://dx.doi.org/10.21518/ms2024-008.

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Introduction. Dry nose syndrome is a polyetiological condition that is common among patients of all age groups from infancy to profoundly old age. The low effectiveness of treatment is associated with the progression of atrophic mucous membrane degeneration, which also affects the cartilaginous and bony parts of the nasal cavity. Significant impairment of the protective, respiratory and olfactory function leads to decreased quality of life of patients, delayed adaptation, and arrested psychosomatic and physical development of children. Herbal medications refer to the agents that have minimal t

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Mameli, Antonello, Martina Salvatorina Murgia, Germano Orrù, and Cinzia Casu. "Extended Erosive Oral Lichen Planus Treated with a very Low-Level Laser Therapy: A Case Report." Open Dentistry Journal 14, no. 1 (2020): 687–91. http://dx.doi.org/10.2174/1874210602014010687.

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Background: Oral lichen planus is a chronic idiopathic inflammatory disease that affects the skin and mucous membrane and involves about 1-2% of the population. The management of this pathology aims to control symptoms. Clinically, it can appear as a plaque, in reticular form, or an erythematous/atrophic form. The treatment options include different classes of drugs and non-drug therapies such as a laser. In addition, most drug treatments include numerous side effects. Objective: The aim of this work is to evaluate the clinical effectiveness of a particular type of very Low-Level-Laser Therapy

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Sharma, Deepak, Amit Sharma, and Rajeev Garg. "Preparation, Physicochemical Evaluation and Characterization of Mucoadhesive Buccal Gels Impregnated with Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis: Effect of Different Grades of HPMC Polymer on In vitro and Ex vivo Performance." Drug Delivery Letters 9, no. 4 (2019): 341–57. http://dx.doi.org/10.2174/2210303109666190529123029.

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Background: Drug delivery across the buccal mucosal epithelium membrane is one of the promising routes to treat various recurrent ailments of the oral cavity. Aphthous stomatitis is an inflammatory oro-mucosal disorder associated with mucous membranes of mouth, cheek, lips, tongue or gingival region. Benzydamine Hydrochloride was designated as a drug of choice by virtue of its anesthetic, antimicrobial, analgesic, anti-inflammatory and antibacterial action. The medication administration through the buccal route is very testing because of restricted absorption area, shorter residence time and m

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Wang, Ruxuan, Xiaoyi Yang, Shen You, et al. "Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice." Pharmaceuticals 15, no. 11 (2022): 1327. http://dx.doi.org/10.3390/ph15111327.

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Chlorogenic acid (CGA) is a phenylpropyl substance synthesized through the shikimic acid pathway. In addition to its anti-tumor, anti-inflammatory, and antioxidant abilities, CGA also has immunomodulatory effects. The aim of the present study is to investigate the therapeutic effects of CGA on the skin damage and arthritis caused by systemic lupus erythematosus (SLE) in an MRL/lpr mouse model. In the SLE model, female MRL/lpr mice at the age of 10 weeks old were treated with CGA daily or cyclophosphamide (CTX) weekly via intraperitoneal injection for three months. After treatment, CGA can sign

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Essler, Jennifer L., Paige G. Smith, Danielle Berger, et al. "A Randomized Cross-Over Trial Comparing the Effect of Intramuscular Versus Intranasal Naloxone Reversal of Intravenous Fentanyl on Odor Detection in Working Dogs." Animals 9, no. 6 (2019): 385. http://dx.doi.org/10.3390/ani9060385.

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Fentanyl is a potent opioid used clinically as a pain medication and anesthetic but has recently seen a sharp rise as an illicit street drug. The potency of fentanyl means mucous membrane exposure to a small amount of the drug can expose first responders, including working canines, to accidental overdose. Naloxone, a fast-acting opioid antagonist administered intranasally (IN) or intramuscularly (IM) is currently carried by emergency personnel in the case of accidental exposure in both humans and canines. Despite the fact that law enforcement relies heavily on the olfactory abilities of canine

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Krivopalov, A. A., S. V. Ryazantsev, E. Yu Mironov, A. M. Korkmazov, and N. V. Kornova. "Brief history of adrenomimetics and improved combinations in treatment of upper respiratory tract diseases." Russian Otorhinolaryngology 23, no. 1 (2024): 101–10. http://dx.doi.org/10.18692/1810-4800-2024-2-101-110.

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One of the important components in the treatment of inflammatory diseases of the upper respiratory tract is the use of topical adrenomimetics, the irrational use of which leads to the development of local and systemic side effects. To minimize the negative effects, it is necessary to use modern vasoconstrictive drugs that have a complex effect due to the addition of medicines to their composition that improve mucociliary clearance, moisturize the mucous membrane of the nasal cavity and paranasal, regeneration processes. The aim of the work was to study the possibility of effective use of a dec

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Pizova, N. V. "Effects of dipyridamole and its use in neurology." Meditsinskiy sovet = Medical Council, no. 19 (December 1, 2021): 41–48. http://dx.doi.org/10.21518/2079-701x-2021-19-41-48.

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Dipyridamole has been on the pharmaceutical market since 1959 and, as a pyrimidyl-pyrimidine compound, has a variety of mechanisms of action. The very first action of dipyridamole was its antianginal effect. In subsequent years, attention was drawn to the antiplatelet properties of dipyridamole, which are related to inhibition of platelet phosphodiesterase as well as to blocking adenosine transport. Another important property of dipyridamole is its effect on the deformability of red blood cells, thereby improving microcirculation. Dipyridamole affects changes in the dynamics of platelet activi

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