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Dissertations / Theses on the topic 'Multi Drug Resistant (MDR)'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Dandachi, Iman. "Multi drug resistant organisms in Lebanese livestock." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0286/document.

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De nos jours, l'épidémiologie des bactéries multi-résistantes a évolué et ne se limite plus aux milieux hospitaliers. En effet, les animaux sont désormais considérés comme d’importants réservoirs de bactéries multi-résistantes, notamment des Bacilles à Gram négatif sécréteurs de bêta-lactamases et/ou résistant à la colistine. L'émergence de ces bactéries chez les animaux est due principalement à l’utilisation excessive d’antibiotiques en tant que prophylaxie et facteurs de croissance. Le transfert d’organismes multi-résistants aux antibiotiques provenant d’animaux vers les humains est un probl

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2

Firfirey, Nousheena. "Occupational adaptation : the experiences of adult patients with MDR- TB who undergo long- term hospitalisation." University of the Western Cape, 2011. http://hdl.handle.net/11394/5300.

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Magister Scientiae (Occupational Therapy) - MSc(OT)<br>TB is a multi- faceted public health problem spurred on by the biological progression of the disease as well as the social issues associated with it. The treatment of TB is however primarily driven by the medical model where the focus is on the disease and not on a holistic view of the patient. Occupational therapy is a profession concerned with the use of occupation in the promotion of health and well being through the facilitation of the process of occupational adaptation. There is however a paucity of literature pertaining to the

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3

Firfirey, Nousheena. "The evaluation of the integrated client-centred intervention programme (ICIP) for clients with MDR-TB at DP Marais Hospital in the Western Cape." University of Western Cape, 2020. http://hdl.handle.net/11394/7687.

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Philosophiae Doctor - PhD<br>Although TB is a curable communicable disease, poor adherence to TB treatment is a major barrier to TB control in South Africa as it increases the risks of morbidity, mortality and drug resistance at individual and community level. As a result, multi-drug-resistant TB (MDR-TB) has become a serious public health issue. Underpinning this study was the assumption that a client-centred approach to treatment of MDR-TB clients, with a hospital programme which adopts an integrated multidisciplinary approach that is client-centred and is not purely biomedically driven

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4

Vallie, Razia. "Assessing and comparing the effectiveness of treatment for multidrug resistant tuberculosis between specialized TB hospital in-patient and general outpatient clinic settings within the Western Cape Province, South Africa." University of the Western Cape, 2016. http://hdl.handle.net/11394/5600.

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Magister Public Health - MPH<br>Background: Multidrug resistant tuberculosis (MDR TB) is a growing threat globally. The large increase in the incidence and prevalence of MDR TB in South Africa in recent years has impacted on the way in which MDR TB is managed within the health services. It became logistically difficult to manage MDR TB by treating all patients as in-patients in a specialized tuberculosis (TB) hospital. The clinics, which are run by nurses and/or general medical officers, are then required to manage this more complex form of TB, with limited resources, less experience an

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5

Greeff, Wildine Marion. "Ototoxicity Monitoring using Automated Extended High-Frequency Audiometry and the Sensitive Range of Ototoxicity in Patients with MDR-TB." Master's thesis, Faculty of Health Sciences, 2021. http://hdl.handle.net/11427/32696.

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Background: Disabling hearing loss is a global burden. This burden is worsened by the emergence of multi-drug resistant tuberculosis (MDR-TB). Some of the medications used to treat MDR-TB are damaging to the cochlea and auditory nerve (ototoxic) and can lead to permanent hearing loss and/or balance disorders. Ototoxicity monitoring aims to reduce this burden by preventing or minimising the damage caused by ototoxic treatment as it can progress and worsen speech perception difficulties. However, the proposed test battery for ototoxicity monitoring is lengthy and demands active participation whi

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6

Sheth, Disha B. "Multielectrode platform for measuring oxygenation status in multicellular tumor spheroids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301516012.

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7

Jikijela, Olwethu. "Clinical characteristics and treatment outcomes of multi-drug resistant tuberculosis patients attending a hospital in Buffalo City Metropolitan Municipality, Eastern Cape." University of the Western Cape, 2018. http://hdl.handle.net/11394/6423.

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Magister Public Health - MPH (Public Health)<br>The presence of highly effective medicines has made very little impact in reducing deaths as a result of tuberculosis (TB), a curable condition but when managed inappropriately, may result in Drug Resistant TB. TB accounts for about one in four deaths that occur in HIV positive people and HIV has been found to be a risk factor for complex unfavorable outcomes in MDR TB patients and a very strong predictor for death and default. The relationship between diabetes and TB has also been explored, with some authors identifying diabetes as a risk f

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8

Shah, Monic. "Antimicrobial Nanoparticles: A Green and Novel Approach for Enhancing Bactericidal Efficacy of Commercial Antibiotics." TopSCHOLAR®, 2014. http://digitalcommons.wku.edu/theses/1389.

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On the verge of entering the post-antibiotic era, numerous efforts are in place to regain the waning charm of antibiotics which are proving ineffective against most “Superbugs”. Engineered nanomaterials, especially gold nanoparticles (GNPs) capped with antibacterial agents, are proving to be an effective and novel strategy against multidrug resistant (MDR) bacteria. In this study, we report a one-step synthesis of antibioticcapped GNPs (25 ± 5 nm) utilizing the combined reducing and capping ability of a cephalosporin antibiotic, ceftazidime. No signs of aggregation or leaching of ceftazidime f

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9

Giyose, Patela. "Strategies used to implement the national guidelines on preventing and early management of multi-drug resistant tuberculosis (MDR-TB) at the buffalo city municipality clinics in East London Eastern Cape province." Thesis, University of Fort Hare, 2013. http://hdl.handle.net/10353/1297.

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The purpose of the study was to explore and describe the strategies used by nurses to implement the national treatment guidelines to prevent, detect and manage multi-drug resistant tuberculosis (MDR-TB) patients. Tuberculosis remains one of the leading infectious diseases and the major cause of death worldwide with estimates of 9.2 million new TB cases in 2008 and 1.7 deaths including 200 000 in clients co-infected with HIV. South Africa is currently ranked 3rd among the 22 high TB burden countries in the world. The HIV/AIDS epidemic contributes significantly to the upward trend in TB morbidit

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10

Alame, Ghina. "Étude de la réversion du phénotype de Multi Drug Resistance (MDR) par de nouveaux dérivés stéroïdiens, in vitro sur des lignées cellulaires humaines et murines résistantes et in vivo par xénogreffes." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00877481.

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La chimiorésistance des cancers est caractérisée par une résistance pléïotropique à de multiples médicaments. Ce mécanisme est en partie causé par la surexpression des transporteurs à "ATP binding cassette" (Pgp, MRP1, BCRP...). Les inhibiteurs connus de ces transporteurs comme la cyclosporine A, le vérapamil et le RU486 sont toxiques à doses élevées. Dans cette étude, de nombreux dérivés stéroïdiens synthétisés au laboratoire à base de progestérone ou d'acides biliaires ont été évalués pour leur capacité à inhiber les transporteurs ABC et plus spécifiquement les fonctions de transport par la

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11

Wilburn, Kaylee Marie. "Isolation and Characterization of Broad Host Range Phage that infect P. aeruginosa Pathogens." Bowling Green State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1594224687661359.

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12

Aguilar, Mónica Alejandra Pavez. "Análise molecular da expressão do fenótipo multi-droga resistente (MDR) em enterobactérias isoladas de amostras clínicas após exposição in vitro ao Imipenem." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-22062015-153149/.

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Após o surgimento e disseminação das β-lactamases de amplo espectro em membros da família Enterobacteriaceae, os antibióticos carbapenêmicos (imipenem, meropenemeertapenem) têm sido considerados a terapia de escolha devido à estabilidade apresentada contra estas enzimas. A desvantagem destes antibióticos é a sua capacidade de induzir resistência aos β-lactâmicos e a outros antibióticos quimicamente não relacionados. O imipenem tem favorecido a indução de cefalosporinases cromossômicas (AmpC) e também tem sido relacionado, in vivo, com a seleção de mecanismos intrínsecos de resistênci

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13

Morrison, Scott Macdonald. "Elucidation of the structure activity relationship of the multi drug resistance (Mdr) transport protein (NorA) of Escherichia coli and the putative protein (HP1181) of Helicobacter pylori." Thesis, University of Leeds, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270864.

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14

Liu, Miaomiao. "Actinomycetes Sourced From Unique Environments as a Promising Source of New TB-Active Natural Products." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/366523.

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Tuberculosis (TB) is the leading cause of death from infectious diseases in the world, affecting more than ten million patients each year. However, multi-drug resistance (MDR-TB) threatens progress achieved in TB care and control, and there are few drugs available to treat MDR-TB. Our overall aim was to identify anti-TB natural products from microbes sourced from unique environments. This thesis presents efforts to achieve an effective approach to identify anti-TB microbial natural products with the combination of one strain many compounds (OSMAC) strategy, NMR fingerprint and principal compon

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15

AMBIKA, KM. "ROLE OF LACTOSMART AS A NOVEL THERAPEUTIC AGENT IN ANTIMICROBIAL DEFENSE." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18433.

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The emergence of multi – drug resistance (MDR ) in microorganisms against antibiotics has become a global problem [1,2,3]. Various conventional drugs with promised efficacy and specificity are unable to withstand the threat of antibiotic drug resistance [4,5,6]. The rising crisis of MDR bacteria has led to the channelization of relevant research in the direction of antimicrobial molecules from natural sources as potential novel antibiotics. The spectrum of innate immune proteins and their potent fragments herald a promising approach to fight the problem of drug resistance. Among the na

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16

Halley, Patrick D. "DNA Origami as a Drug Delivery Vehicle for in vitro and in vivo Applications." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1480632777328142.

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17

Patel, Fadheela. "Development of a cost-effective drug sensitivity test for multi-drug resistant and extensively drug-resistant tuberculosis." Thesis, Cape Peninsula University of Technology, 2010. http://hdl.handle.net/20.500.11838/1496.

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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2010<br>The World Health Organisation estimates that nine million people are infected with tuberculosis (TB) every year of which ninety-five percent live in developing countries. Africa has one of the highest incidences of TB in the world. but few of its countries are equipped to diagnose drug-resistant TB. This study aimed to develop a robust. yet simple and cost-effective assay. which would require minimal sophisticated instrumentation and specialised personnel that would make drug sensitivity screening for

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18

Smith, Louise. "Resilience of the partners of long term hospitalised patients with multidrug-resistant (MDR) and extreme drug-resistant (XDR) tuberculosis (TB)." Thesis, Nelson Mandela Metropolitan University, 2013. http://hdl.handle.net/10948/d1020913.

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Patients diagnosed with Multidrug-resistant(MDR) and Extreme drug-resistant (XDR) tuberculosis (TB) have to be hospitalised for a period of six to twelve months, according to the MDR/XDR Policy Guidelines on the treatment of drug-resistant TB – until the patient recovers, and is no longer infectious. There are factors associated with both the patients’ and their partners’ (spouses) resistance to long-term hospitalisation. This has resulted in several acts of violence against the hospital property and members of the health-care team. However, there are a small number of partners who assist the

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19

Kuzeljevic, Brigitta. "The Potentials and Difficulties of Two New Drugs, TMC 207 and PA-824, against Drug-Susceptible and Drug-Resistant Strains of Mycobacterium tuberculosis." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-25284.

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Tuberculosis has for decades been the leading cause of death, worldwide, originating from merely one infectious matter i.e. the bacilli Mycobacterium tuberculosis (MTB). It is killing approximately 1.5 million people every year. The World Health Organization (WHO) estimates that 2 billion people might be infected by this specific bacterium, and that there emerges about 9 million new, active cases of TB each year. The aim with this thesis is to elucidate the possibilities and the difficulties with two new drugs against susceptible and resistant, latent and replicating strains of M. tuberculosis

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20

Stoffels, Karolien. "Contribution to the research on drug resistant Mycobacterium tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209194.

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Tuberculosis (TB) is a potentially fatal contagious disease that can affect almost any part of the body but is mainly an infection of the lungs. It is caused by micro-organisms of the Mycobacterium tuberculosis complex. It is the second greatest killer worldwide due to a single infectious agent, after the Human Immunodeficiency Virus (HIV). Without treatment, fatality is 50% in immune competent persons. TB remains the leading cause of death among HIV positive persons, causing one fifth of the deaths. The World Health Organization estimates that one third of the world population is infected by

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21

MATTIONI, MARCHETTI VITTORIA. "Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) Gram-negative bacteria of clinical interest: laboratory diagnosis, clinical management and infection control." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1301308.

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Antimicrobial resistance (AMR) represents one of the major 21st century public health tasks: its increasing has reduced the effective prevention and treatment strategies against infection events. The problem of AMR is especially urgent for Gram-negative bacteria, on which an over-/inappropriate use (incorrect choices, inadequate dosing, and poor adherence to treatment guidelines) of antibiotics have acted as a selective pressure, favouring the survival and multiplication of strains with acquired antibiotic-resistant traits. The aim of my PhD research were: i) to perform an evaluation and chara

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22

Hayes, Cindy. "Prevalence and resistance gene mutations of multi-drug resistant and extensively drug resistant mycobacterium tuberculosis in the Eastern Cape." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/d1020374.

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The emergence and spread of multi-drug resistant (MDR-TB) and extensively drugresistant tuberculosis (XDR-TB) are a major medical and public problem threatening the global health. The objectives of this study were to (i) determine the prevalence of MDR-TB and XDR-TB in the Eastern Cape; (ii) analyze patterns of gene mutations in MDR-TB and (iii) identify gene mutations associated with resistance to second line injectable drugs in XDR-TB isolates. A total of 1520 routine sputum specimens sequentially received within a period of 12 months i.e. February 2012 to February 2013 from all MDR-TB and X

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23

Nhokwara, Primrose Tinashe. "Factors that influence the utilisation of ototoxicity monitoring services for patients on treatment for drug-resistant tuberculosis." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15683.

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Multi-drug resistance is increasingly becoming a challenge to tuberculosis control programmes globally. Treatment of multi-drug resistance tuberculosis (MDR-TB) includes aminoglycoside antibiotics which are known to cause hearing loss. Ototoxicity monitoring services are often provided to patients undergoing treatment for MDR-TB for early detection of ototoxic hearing loss to facilitate alerting the patients and relevant medical staff about the presence and progression of any hearing loss. Previously, models of managing patients with MDR-TB required mandatory hospitalization for at least 6 mon

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Mahfouz, Norhan, Serena Caucci, Eric Achatz, et al. "High genomic diversity of multi-drug resistant wastewater Escherichia coli." Nature Publishing Group, 2018. https://tud.qucosa.de/id/qucosa%3A32482.

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Wastewater treatment plants play an important role in the emergence of antibiotic resistance. They provide a hot spot for exchange of resistance within and between species. Here, we analyse and quantify the genomic diversity of the indicator Escherichia coli in a German wastewater treatment plant and we relate it to isolates’ antibiotic resistance. Our results show a surprisingly large pan-genome, which mirrors how rich an environment a treatment plant is. We link the genomic analysis to a phenotypic resistance screen and pinpoint genomic hot spots, which correlate with a resistance phenotype.

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Hoang, Thi Thanh Thuy. "An analysis of multi drug resistant tuberculosis control in Vietnam." Thesis, Open University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.700287.

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Multi-drug resistant tuberculosis is a major global health problem. Viet Nam is 14th among 27 MDR-TB high burden countries with an estimated about 5,100 MDR-TB cases among notified TB cases per year. Management of MDR-TB in Viet Nam is one of the main objectives of the TB control programme. This thesis provides an understanding of the current situation of MDRlXDR-TB in Vietnam and its control policies focusing on case finding strategy, targeting groups for MDR-TB screening. MDR-TB contacts, one of the high risk groups recommended by the WHO is a focus of this thesis. The thesis presents screen

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Leangapichart, Thongpan. "Phenotypic and genomic analysis of multi-drug resistant bacteria in travelers." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0183.

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La résistance aux antibiotiques chez les bactéries est un problème majeur mondial du fait de son augmentation. Récemment, la transmission des bactéries résistantes aux humains, aux animaux et à l’environnement sont de plus en plus décrits dans la littérature. Ces dernières années, les voyages internationaux ont augmenté massivement ce qui a permis aux bactéries résistantes de se propager d’un lieu à un autre. Les voyageurs internationaux sont les principaux acteurs de l’acquisition et de la propagation des gènes de résistance aux antibiotiques. Le plus grand rassemblement annuel de personnes c

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Gebreyes, Wondwossen Abebe. "Molecular Epidemiology of Multi-drug resistant Salmonella in swine production systems." NCSU, 2001. http://www.lib.ncsu.edu/theses/available/etd-20010928-104421.

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<p>The swine industry is often implicated as one of the most significant contributors to foodborne Salmonella infections in humans. As the trend in swine production in the United States is toward larger and more intensive farms, but fewer farm units, it is likely that antimicrobial usage is also increasing. The purpose of this research was to study antimicrobial resistance and determine phenotypic and genotypic diversity of multi-drug resistant Salmonella in swine production systems. We found resistance to specific classes of antimicrobials including tetracycline, b-lactams and chloramphenicol

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Fleeman, Renee. "Discovering Antibacterial and Anti-Resistance Agents Targeting Multi-Drug Resistant ESKAPE Pathogens." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6839.

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Antibiotic resistance has been a developing problem for mankind in recent decades and multi-drug resistant bacteria are now encountered that are resistant to all treatment options available. In 2014, the World Health Organization announced that this problem is driving us towards a “post-antibiotic era” that will change the face of modern medicine as we know it. If lack of novel antibiotic development and FDA approval continues, by the year 2050, 10 million people will die each year to an antimicrobial resistant bacterial infection. With lack of pharmaceutical industry involvement in developing

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Sultana, Razvan. "High-throughput genotyping and fingerprinting of mycobacterium tuberculosis multi-drug resistant strains." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31612.

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Thesis (Ph.D.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Multiple drug resistance in Mycobacterium tuberculosis poses both significant treatment and epidemiological challenges. Measuring drug resistance in clinical settings is time consuming and prone to errors, pr

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Siu, Kit-hang, and 蕭傑恆. "Molecular characterization of multi-drug resistance mechanisms in mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46076219.

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Al-Maaini, Rahma Ali Saleh. "Honey as an antimicrobial agent against multi-drug resistant Gram negative bacterial rods." Thesis, Cardiff Metropolitan University, 2012. http://hdl.handle.net/10369/3264.

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Honey has been shown to have therapeutic properties, which include immunomodulatory and antibacterial activity in vitro and anti-inflammatory, antipyretic and wound healing properties in vivo. A complex mix of factors such as acidity, osmolality and hydrogen peroxide content contribute to antibacterial activity. Unusually manuka honey has been shown to contain methylglyoxal which is derived from nectar collected from the blossom of manuka trees and this confers high antibacterial activity. Manuka honey is used in licensed wound dressings in the UK. Its ability to inhibit staphylococci has been

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Mekler, Kathryn Ann. "Factors influencing the decentralisation of Multi-Drug Resistant Tuberculosis care: A management perspective." University of the Western Cape, 2018. http://hdl.handle.net/11394/6866.

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Master of Public Health - MPH<br>Decentralisation of multi-drug resistant tuberculosis (MDR-TB) services has resulted in improved access to care, with community-based treatment of MDR-TB shown to be more effective than centralised hospital-based care. Furthermore, increasing bed shortages resulted in the National Department of Health establishing MDR-TB policy guidelines in 2011. However, the extent to which this policy has been implemented by the decentralised MDR- TB sites and the factors influencing implementation of the policy from a management perspective were not well described. The ai

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Willsey, Graham Geier. "Detection Of The Lung Environment By Multi-Drug Resistant Gram-Negative Bacterial Pathogens." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/978.

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Nosocomial lung infections are a growing concern in the United States, with more than 300,000 cases reported annually. More than 30 % of which are caused by the Gram-negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumoniae. Similarly, Gram-negative bacteria establish chronic infections in individuals with cystic fibrosis (CF) that are difficult or impossible to eradicate.P. aeruginosa has historically been one of the most prevalent pathogens of adults with CF. However, as antipseudomonal therapy has improved, more antibiotic resistant species have taken hold, including Stenotrophomo

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Noyce, Jonathan Oliver. "Electrostatic bacterial control." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274692.

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Jönsson, Videsäter Kerstin. "Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-889-0/.

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Ashley, Elizabeth. "New directions inartemisinin-based combination therapy : chemotherapeutic studies of multi-drug resistant falciparum malaria." Thesis, Open University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446295.

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Phee, Lynette. "Unorthodox antimicrobial combination therapies for the treatment of multi-drug resistant Gram-negative infections." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/44695.

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The rise of antimicrobial resistance (AMR) has culminated in the most pressing problem in modern medicine. The situation is most acute with regards to the management of multi- drug resistant Gram-negative infections (MDRGNB) with common infections increasingly untreatable due to rapidly dwindling therapeutic options. A solution to the problem of AMR is unlikely to be easily found, but revisiting and re-purposing existing antimicrobials is a viable approach in the medium term. This study investigated the use of unorthodox antimicrobial combination therapies for the treatment of MDRGNB, with par

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Azores, Molovon Jr Pasagui. "Possible Risk Factors for Multidrug-Resistant Tuberculosis Infection in the Philippines." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3551.

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Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is a leading cause of morbidity and mortality in the Philippines. The purpose of this study was to gain knowledge about the relationship between potential risk factors and MDR-TB. Risk factors (the independent variables) for MDR-TB (the dependent variable) include previous TB treatment, infection with HIV, exposure to patients with drug-susceptible TB/MDR-TB, delays in diagnosis and treatment, employment status, smoking, imprisonment, alcohol abuse, and poor compliance with TB treatment regimens. The study was based on the epidemiological

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Tinzi, Siphokuhle. "Exploration of experiences of patients with the adverse-drug effects of multidrug-resistant tuberculosis treatment in a primary health care facility in the Western Cape." University of the Western Cape, 2017. http://hdl.handle.net/11394/5660.

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Magister Curationis - MCur<br>Multidrug resistant TB (MDR-TB) is a form of TB caused by bacteria (germs) that are resistant to the usual drugs that are used to treat "normal" TB. The duration of treatment for MDR-TB is a maximum of 22 months. People with MDR-TB are treated in specialized tertiary hospitals and in out-patient clinics in the PHC facilities. The treatment includes a six months injectable phase with a wide range of TB drugs. The adverse effects of MDR-TB drugs are among the worst side effects ever reported by patients. The aim of the current study was to explore the experiences of

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Machado, Lisa Santos. "The inhibitory activity of synthetic compounds and ions against transporters of multi-drug resistant bacteria." Master's thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2011. http://hdl.handle.net/10362/7712.

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RESUMO: Sessenta e três derivados de hidantoína foram utilizados para avaliar possíveis efeitos de modulação na actividade das bombas de efluxo (BE) na Salmonella NCTC 13349 utilizando um método fluorimétrico semi-automático. Nenhum dos compostos apresentaram actividade anti-bacteriana até concentrações de 240 mg/L. Entre todos os compostos, SZ-7 demonstrou possuir propriedades de modulação de effluxo na presença de glucose. Para testar esta actividade, estirpes de Salmonella resistentes à ciprofloxacina, induzidas a elevados níveis de resistência com sobre-expressão de BE, foram expostas ao S

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Gounden, Ronald. "Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/3282.

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Includes bibliographical references (leaves 42-47).<br>Background: Nosocomial infections due to multi-drug resistant Acinetobacter baumannii are often treated with colistin, but there are few data comparing its safety and effectiveness with other antimicrobials, particularly the aminoglycosides. Metbods: A retrospective cohort study of patients treated with colistin or tobramycin for A. baumannii infections in intensive care units (ICUs) at Groote Schuur hospital was performed. Colistin was used for A baumannii isolates which were resistant to all other available antimicrobials. Tobramycin was

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42

Prinsloo, Andrea. "Susceptibility and synergism profiles of multi-drug resistant pseudomonas aeruginusa in an intensive care environment." Diss., University of Pretoria, 2003. http://hdl.handle.net/2263/28026.

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43

Hansen, Tarrant William. "Evaluation of molecular methods used for the rapid detection of multi-drug resistant Mycobacterium tuberculosis." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/20723/1/Tarrant_Hansen_Thesis.pdf.

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Tuberculosis remains a major public health issue globally, with an estimated 9.2 million new cases in 2006. A new threat to TB control is the emergence of drug resistant strains. These strains are harder to cure as standard anti-tuberculosis first line treatments are ineffective. Multi Drug Resistant Tuberculosis (MDR-TB) is defined as Mycobacterium tuberculosis that has developed resistance to at least rifampicin and isoniazid, and these strains now account for greater than 5% of worldwide cases. Mutations within the Rifampicin Resistance Determining Region (RRDR) of the rpoB gene are pre

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44

Hansen, Tarrant William. "Evaluation of molecular methods used for the rapid detection of multi-drug resistant Mycobacterium tuberculosis." Queensland University of Technology, 2008. http://eprints.qut.edu.au/20723/.

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Tuberculosis remains a major public health issue globally, with an estimated 9.2 million new cases in 2006. A new threat to TB control is the emergence of drug resistant strains. These strains are harder to cure as standard anti-tuberculosis first line treatments are ineffective. Multi Drug Resistant Tuberculosis (MDR-TB) is defined as Mycobacterium tuberculosis that has developed resistance to at least rifampicin and isoniazid, and these strains now account for greater than 5% of worldwide cases. Mutations within the Rifampicin Resistance Determining Region (RRDR) of the rpoB gene are pre

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45

Heinrich, Anne-Kathrin [Verfasser]. "Overcoming drug resistance by stimulus-sensitive drug delivery systems : a preclinical characterization of polymer-drug conjugates for the treatment of multi-drug resistant cancer / Anne-Kathrin Heinrich." Halle, 2017. http://d-nb.info/1144955262/34.

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46

Katvars, Laura K. "Novel cationic peptides and polymers in the treatment of methicillin-resistant Staphylococcus aureus and multi-drug resistant Acinetobacter spp. skin infection isolates." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228984.

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47

Eaton, Joanna. "Multi-drug resistant Gram-negative bacteria in wastewater treatment plants : -With focus on Acinetobacter baumannii complex." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84457.

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Multidrug-resistant (MDR) pathogens are emerging problems humanity faces today. Increasing MDR Gram-negative bacteria is not only a threat towards humanity itself but also towards food safety. The genus Acinetobacter is an environmental bacterium that can be found in habitats, including aquatic environments, soil, wastewater, food, and animals. Acinetobacter spp. is naturally resistant to a broad spectrum of antibiotics and quickly develop resistance due to their OXA β-lactamases enzyme set. Their broad-spectrum resistance makes infections caused by Acinetobacter hard to treat. The study aimed

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48

Reese, Daysia Marie. "Surveillance for Multi-Drug Resistant Salmonella enterica Serovar Heidelberg in Livestock Markets." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159308819243022.

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49

Diogo, Gil Reynolds. "Characterization of IL-4Δ2 and assessment of its potential in immunotherapy for multi-drug resistant tuberculosis". Thesis, St George's, University of London, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706520.

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Despite the availability of the Bacillus Calmette-Guerin (BCG) vaccine and current drug regimens, tuberculosis (TB) remains an ever growing global health burden, even more so with the emergence of new drug resistant strains. Therefore it is necessary to improve treatment regimens. Disproportionately high levels of the major Th2 cytokine, IL-4, have been linked to poor TB prognosis. However, T-lymphocytes also produce an alternative IL-4 variant (IL-4Δ2) which can antagonise its activity, and it is the ratio of IL-4 and its antagonist that has been associated with clinical status of Mycobacteri

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50

Takeda, Haruhiko. "Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing." Kyoto University, 2018. http://hdl.handle.net/2433/232107.

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