Relevant bibliographies by topics / Multi-Target-Directed Ligands

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Academic literature on the topic 'Multi-Target-Directed Ligands'

Author: Grafiati
Published: 24 April 2022
Last updated: 18 July 2025

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Journal articles on the topic "Multi-Target-Directed Ligands"

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Bajda, M., N. Guzior, M. Ignasik, and B. Malawska. "Multi-Target-Directed Ligands in Alzheimer's Disease Treatment." Current Medicinal Chemistry 18, no. 32 (2011): 4949–75. http://dx.doi.org/10.2174/092986711797535245.

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Cavalli, Andrea, Maria Laura Bolognesi, Anna Minarini, et al. "Multi-target-Directed Ligands To Combat Neurodegenerative Diseases." Journal of Medicinal Chemistry 51, no. 3 (2008): 347–72. http://dx.doi.org/10.1021/jm7009364.

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Cavalli, Andrea, Maria Laura Bolognesi, Anna Minarini, et al. "Multi-Target-Directed Ligands To Combat Neurodegenerative Diseases." Journal of Medicinal Chemistry 51, no. 7 (2008): 2326. http://dx.doi.org/10.1021/jm800210c.

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Rodríguez-Soacha, Diego Alejandro, Matthias Scheiner, and Michael Decker. "Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands." European Journal of Medicinal Chemistry 180 (October 2019): 690–706. http://dx.doi.org/10.1016/j.ejmech.2019.07.040.

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Knez, Damijan, Izidor Sosič, Anja Pišlar, et al. "Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer’s Disease." Current Alzheimer Research 16, no. 9 (2019): 801–14. http://dx.doi.org/10.2174/1567205016666191010130351.

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Background: Accumulating evidence suggests that multi-target directed ligands have great potential for the treatment of complex diseases such as Alzheimer’s Disease (AD). Objective: To evaluate novel chimeric 8-hydroxyquinoline ligands with merged pharmacophores as potential multifunctional ligands for AD. Methods: Nitroxoline, PBT2 and compounds 2-4 were evaluated in-vitro for their inhibitory potencies on cathepsin B, cholinesterases, and monoamine oxidases. Furthermore, chelation, antioxidative properties and the permeability of Blood-Brain Barrier (BBB) were evaluated by spectroscopy-based
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do Carmo Carreiras, Maria, Lhassane Ismaili, and José Marco-Contelles. "Propargylamine-derived multi-target directed ligands for Alzheimer’s disease therapy." Bioorganic & Medicinal Chemistry Letters 30, no. 3 (2020): 126880. http://dx.doi.org/10.1016/j.bmcl.2019.126880.

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Denya, Ireen, Sarel F. Malan, Adaze B. Enogieru, et al. "Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease." MedChemComm 9, no. 2 (2018): 357–70. http://dx.doi.org/10.1039/c7md00569e.

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Jones, Michael R., Emilie Mathieu, Christine Dyrager, et al. "Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease." Chemical Science 8, no. 8 (2017): 5636–43. http://dx.doi.org/10.1039/c7sc01269a.

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Rossi, Michele, Michela Freschi, Luciana de Camargo Nascente, et al. "Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease." Journal of Medicinal Chemistry 64, no. 8 (2021): 4972–90. http://dx.doi.org/10.1021/acs.jmedchem.1c00048.

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Bhatia, Rohit, Sankha S. Chakrabarti, Upinder Kaur, Gaurav Parashar, Anindita Banerjee, and Ravindra K. Rawal. "Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer’s Disease." Current Alzheimer Research 18, no. 10 (2021): 802–30. http://dx.doi.org/10.2174/1567205018666211208140551.

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Alzheimer’s disease (AZD) is an age-associated neurodegenerative disorder and is one of the common health issues around the globe. It is characterized by memory loss and a decline in other cognitive domains, including executive function. The progression of AZD is associated with complex events, and the exact pathogenesis is still unrevealed. Various mechanisms which are thought to be associated with the initiation of AZD include a decreased concentration of acetylcholine (ACh), deposition of amyloid-β (Aβ) peptide, dyshomeostasis of redox metal ions, and prolonged oxidative stress. Due to the
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Dissertations / Theses on the topic "Multi-Target-Directed Ligands"

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Simoni, Elena <1979&gt. "Multi-target-directed ligands: application to the Alzheimer's disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2848/1/elena.simoni_tesi.pdf.pdf.

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The MTDL (multi-target-directed ligand) design strategy is used to develop single chemical entities that are able to simultaneously modulate multiple targets. The development of such compounds might disclose new avenues for the treatment of a variety of pathologies (e.g. cancer, AIDS, neurodegenerative diseases), for which an effective cure is urgently needed. This strategy has been successfully applied to Alzheimer’s disease (AD) due to its multifactorial nature, involving cholinergic dysfunction, amyloid aggregation, and oxidative stress. Despite many biological entities have been recognized
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Simoni, Elena <1979&gt. "Multi-target-directed ligands: application to the Alzheimer's disease." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2848/.

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The MTDL (multi-target-directed ligand) design strategy is used to develop single chemical entities that are able to simultaneously modulate multiple targets. The development of such compounds might disclose new avenues for the treatment of a variety of pathologies (e.g. cancer, AIDS, neurodegenerative diseases), for which an effective cure is urgently needed. This strategy has been successfully applied to Alzheimer’s disease (AD) due to its multifactorial nature, involving cholinergic dysfunction, amyloid aggregation, and oxidative stress. Despite many biological entities have been recognized
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Pérez, Areales Francisco Javier. "Novel multi-target directed ligands as drug candidates against Alzheimer’s disease." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404781.

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Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, current treatments are only symptomatic, but do not prevent, halt, or delay the disease progression. In the light of the multiple mechanisms involved in its pathogenesis, such as dysfunction of cholinergic and glutamatergic neurotransmitter systems, amyloid and tau pathologies, or oxidative stress, among others, the traditional medicinal chemistry approach of developing drugs b
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Milelli, Andrea <1980&gt. "New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1763/1/milelli_andrea_tesi.pdf.

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Alzheimer's disease (AD) and cancer represent two of the main causes of death worldwide. They are complex multifactorial diseases and several biochemical targets have been recognized to play a fundamental role in their development. Basing on their complex nature, a promising therapeutical approach could be represented by the so-called "Multi-Target-Directed Ligand" approach. This new strategy is based on the assumption that a single molecule could hit several targets responsible for the onset and/or progression of the pathology. In particular in AD, most currently prescribed drugs aim to incr
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Milelli, Andrea <1980&gt. "New Synthetic Polyamines as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease and Cancer: Design, Synthesis and Biological Evaluation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1763/.

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Alzheimer's disease (AD) and cancer represent two of the main causes of death worldwide. They are complex multifactorial diseases and several biochemical targets have been recognized to play a fundamental role in their development. Basing on their complex nature, a promising therapeutical approach could be represented by the so-called "Multi-Target-Directed Ligand" approach. This new strategy is based on the assumption that a single molecule could hit several targets responsible for the onset and/or progression of the pathology. In particular in AD, most currently prescribed drugs aim to incr
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Guiselin, Thomas. "Cοnceptiοn, synthèse et évaluatiοn biοlοgique de ligands sérοtοninergiques multicibles d’intérêt dans la maladie d’Alzheimer". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMC221.

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La Maladie d’Alzheimer (MA) est une maladie neurodégénérative multifactorielle et est considérée comme la démence la plus commune, liée à l’âge. Actuellement, les médicaments disponibles en France sont en majorité des inhibiteurs de l’acétylcholinestérase (AChE) qui n’offrent que peu d’effets symptomatiques accompagnés d’effets secondaires importants. En parallèle, le système sérotoninergique, hypothèse supplémentaire d’apparition de la maladie, est une cible potentielle pour le traitement de la MA. Son origine multifactorielle a mené au recours croissant à la stratégie pléiotrope, visant à in
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Lanthier, Caroline. "Conception, synthèse et évaluation de nouveaux composés à dualité d'action agoniste des récepteurs 5-HT4 et antioxydante, d'intérêt thérapeutique pléiotrope dans la maladie d'Alzheimer Novel multi target-directed ligands targeting 5-HT 4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease Novel potent Benzisoxazoles targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads for Alzheimer disease." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC415.

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La maladie d’Alzheimer est une maladie neurodégénérative caractérisée par des pertes de mémoire et des troubles cognitifs. Bien qu’à l’heure actuelle, les causes physiopathologiques de la MA ne soient pas entièrement connues, un certain nombre de causes moléculaires ont été identifiées telles que l’agrégation des peptides β-amyloïdes, les dégénérescences neurofibrillaires liées à la protéine Tau, le stress oxydant et les phénomènes de neuroinflammation. Les traitements actuels de la MA sont des traitements symptomatiques tels que les inhibiteurs d’acétylcholinestérase ne permettant pas de trai
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Łozińska, Iwona. "Synteza i badania biologiczne nowych inhibitorów cholinoesteraz zawierających ugrupowanie serotoniny i wybranych pochodnych heterocyklicznych." Doctoral thesis, 2016. https://depotuw.ceon.pl/handle/item/1630.

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Projektowanie nowych inhibitorów cholinoesteraz jest bardzo istotnym elementem poszukiwania leków w chorobie Alzheimera. Wśród obecnie stosowanych farmaceutyków w terapii tej choroby znajduje się m.in. takryna i donepezil, odwracalne inhibitory cholinoesteraz – acetylocholinoesterazy (AChE) oraz butyrylocholinowesterazy (BChE), których pochodne stały się elementami budulcowymi do otrzymania inhibitorów, objętych rozprawą doktorską. Etiologia choroby Alzheimera nie jest jeszcze poznana, natomiast wiadomym jest, iż jest to choroba wieloczynnikowa, w leczeniu której działanie na pojedynczy
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Book chapters on the topic "Multi-Target-Directed Ligands"

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Das, Sucharita, and Soumalee Basu. "Strategies for Multi-Target Directed Ligands: Application in Alzheimer’s Disease (AD) Therapeutics." In Methods in Pharmacology and Toxicology. Springer New York, 2018. http://dx.doi.org/10.1007/7653_2018_8.

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Ortiz, Cindy Juliet Cristancho, Matheus de Freitas Silva, Vanessa Silva Gontijo, Flávia Pereira Dias Viegas, Kris Simone Tranches Dias, and Claudio Viegas. "Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease." In Methods in Pharmacology and Toxicology. Springer New York, 2018. http://dx.doi.org/10.1007/7653_2018_2.

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Patil, Vaishali M., Neeraj Masand, Vertika Gautam, Shikha Kaushik, and Dee Wu. "Multi-Target-Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery." In Deciphering Drug Targets for Alzheimer’s Disease. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-2657-2_13.

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Nepovimova, Eugenie, and Kamil Kuca. "Multi-Target-Directed Ligands in Alzheimer’s Disease Therapy." In Neurodegenerative Diseases - Molecular Mechanisms and Current Therapeutic Approaches [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93269.

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"The Development of Multi-Target-Directed Ligands (MTDL) to Treat Alzheimer’s Disease." In Frontiers in Clinical Drug Research – Alzheimer Disorders, edited by John W. Wright and Joseph W. Harding. BENTHAM SCIENCE PUBLISHERS, 2013. http://dx.doi.org/10.2174/9781608057221113010004.

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Ambure, Pravin, and Kunal Roy. "Computer-Aided Drug Design for the Identification of Multi-Target Directed Ligands (MTDLs) in Complex Diseases: An Overview." In Pharmaceutical Biocatalysis. Jenny Stanford Publishing, 2019. http://dx.doi.org/10.1201/9780429295034-19.

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de Freitas Silva, Matheus, Flávia Pereira Dias Viegas, Vanessa Silva Gontijo, et al. "Multi-functional Ligands and Molecular Hybridization: Conceptual Aspects and Application in the Innovative Design of Drug Candidate Prototypes for Neurodegenerative Diseases." In Frontiers in Clinical Drug Research - CNS and Neurological Disorders. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123319123110003.

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The rapid increase in the incidence of dementia has enormous socio.economic impacts and costs for governmental health systems all over the world. Despite this, finding an effective treatment for the different types of neurodegenerative diseases (NDs) so far represents a challenge for science. The biggest obstacles related to NDs are their multifactorial complexity and the lack of knowledge of the different pathophysiological pathways involved in the development of each disorder. The latest advances in science, especially those related to the systems biology concepts, have given new insights for a better comprehension of such multifactorial networks related to the onset and progression of NDs, and how Medicinal Chemists could act in the search for novel disease-modifying drug candidates capable of addressing the multiple pathological factors involved in neurodegeneration. The multi-target directed ligands (MTDLs) concept has captivated and opened new windows for the creativity and rationality of researchers worldwide in seeking innovative drug candidates capable of modulating different molecular targets by a single multifunctional molecule. In fact, in the last two decades, thousands of research groups have dedicated their efforts to the use of molecular hybridization as the main tool for the rational design of novel molecular scaffolds capable of expressing multi-target biological activity. In this way, this chapter addresses the most recent pathophysiological hallmarks of the most high-impact NDs, represented by Alzheimer’s, Parkinson’s, Huntington’s diseases, and amyotrophic lateral sclerosis, as well as the state-of-art in the design of new MTDLs, inspired mostly by natural products with improved druggability properties.
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Gong Cheng-Xin, Liu Fei, and Iqbal Khalid. "Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease." In Advances in Alzheimer’s Disease. IOS Press, 2018. https://doi.org/10.3233/978-1-61499-876-1-105.

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The amyloid cascade hypothesis has been dominating drug discovery for Alzheimer's disease (AD) for the last two decades. The failure of the development of effective drugs for slowing down or reversing the progression of AD warrants the AD field to consider out-of-the-box thinking and therapeutic approaches. We propose the multifactorial hypothesis of AD, emphasizing that AD is caused by multiple etiological factors, which may result in common brain pathology and functional consequences through several separate but integrated molecular pathways. More than one etiological factor and mechanistic pathway may be involved in a single individual with sporadic AD, and different individuals may have different etiological factors, involving different mechanisms/pathways. We urge the recognition of the multifactorial nature of AD and the paradigm shift of AD drug development from a single target to multiple targets, either with the multitarget-directed ligands approach or the cocktail therapy approach. We believe that patient stratification and the use of the precision medicine model will also benefit AD drug discovery.
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Conference papers on the topic "Multi-Target-Directed Ligands"

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West, Ryan, and Stevan Pecic. "Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.183150.

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Tyagi, Ankit, Shikhar Gupta, and C. Gopi Mohan. "In silicoapproach to discover multi-target-directed ligands for the treatment of Alzheimer's disease." In the International Symposium. ACM Press, 2010. http://dx.doi.org/10.1145/1722024.1722032.

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Pecic, Stevan, Jeannes Angelia, and Xiaohui Weng. "Design, Synthesis and Biological Evaluation of Benzothiazole-Phenyl Analogs as Multi-Target Directed Ligands for Treating Pain." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.143050.

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