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Journal articles on the topic 'Multi-tracer PET imaging'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mahmutovic Persson, Irma, Nina Fransén Pettersson, Jian Liu, et al. "Longitudinal Imaging Using PET/CT with Collagen-I PET-Tracer and MRI for Assessment of Fibrotic and Inflammatory Lesions in a Rat Lung Injury Model." Journal of Clinical Medicine 9, no. 11 (2020): 3706. http://dx.doi.org/10.3390/jcm9113706.

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Non-invasive imaging biomarkers (IBs) are warranted to enable improved diagnostics and follow-up monitoring of interstitial lung disease (ILD) including drug-induced ILD (DIILD). Of special interest are IB, which can characterize and differentiate acute inflammation from fibrosis. The aim of the present study was to evaluate a PET-tracer specific for Collagen-I, combined with multi-echo MRI, in a rat model of DIILD. Rats were challenged intratracheally with bleomycin, and subsequently followed by MRI and PET/CT for four weeks. PET imaging demonstrated a significantly increased uptake of the co

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Fontana, Igor C., Miriam Scarpa, Mona-Lisa Malarte, et al. "Astrocyte Signature in Alzheimer’s Disease Continuum through a Multi-PET Tracer Imaging Perspective." Cells 12, no. 11 (2023): 1469. http://dx.doi.org/10.3390/cells12111469.

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Reactive astrogliosis is an early event in the continuum of Alzheimer’s disease (AD). Current advances in positron emission tomography (PET) imaging provide ways of assessing reactive astrogliosis in the living brain. In this review, we revisit clinical PET imaging and in vitro findings using the multi-tracer approach, and point out that reactive astrogliosis precedes the deposition of Aβ plaques, tau pathology, and neurodegeneration in AD. Furthermore, considering the current view of reactive astrogliosis heterogeneity—more than one subtype of astrocyte involved—in AD, we discuss how astrocyt

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Lyduine, E. Collij, Heeman Fiona, Salvadó Gemma, et al. "Multi-tracer model for staging cortical amyloid deposition using PET imaging." Neurology 95, no. 11 (2020): 1538–53. https://doi.org/10.1212/WNL.0000000000010256.

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<strong>Abstract</strong> Objective: To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. Methods: Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) from 6 cohorts (European Medical Information Framework for AD, Alzheimer's and Family, Alzheimer's Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3, Alzheimer's Disease Neuroima

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Aboian, Mariam, Vahid Ravanfar, Emma Bahroos, et al. "MLTI-18. PRECISION IMAGING OF METASTATIC AND PRIMARY BRAIN TUMORS AFTER RADIATION WITH 18F-FDOPA PET-MRI IS FEASIBLE AND COST EFFECT." Neuro-Oncology Advances 1, Supplement_1 (2019): i18. http://dx.doi.org/10.1093/noajnl/vdz014.077.

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Abstract PURPOSE: Post-radiation changes in the brain can mimic tumor recurrence on MRI, requiring multiple short term follow-ups to differentiate tumor progression from radiation necrosis. We propose combining functional and anatomic imaging with FDOPA PET tracer in hybrid PET-MRI to improve detection of tumor recurrence. MATERIALS AND METHODS: Seventeen adult patients treated with radiation therapy were identified - four with metastatic disease from breast and lung cancer and thirteen with primary brain glioma (11 IDH wildtype glioblastoma and 2 astrocytoma). Patients were scanned on hybrid

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Haslop, Anna, Lisa Wells, Antony Gee, Christophe Plisson, and Nicholas Long. "One-Pot Multi-Tracer Synthesis of Novel 18F-Labeled PET Imaging Agents." Molecular Pharmaceutics 11, no. 11 (2014): 3818–22. http://dx.doi.org/10.1021/mp500324n.

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Ozsahin, Ilker, Efe Precious Onakpojeruo, Berna Uzun, Dilber Uzun Ozsahin, and Tracy A. Butler. "A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging." Pharmaceutics 15, no. 4 (2023): 1304. http://dx.doi.org/10.3390/pharmaceutics15041304.

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The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer’s disease (AD) is the most prevalent of these tauopathies. Immunohistochemical evaluation allows neuropathologists to visualize paired-helical filaments (PHFs)—tau pathological lesions, but this is possible only after death and only shows tau in the portion of brain sampled. Positron emission tomography (PET) imaging allows both the quantitative and qualitative analysis of pathology over the whole brain of a living subject. The abilit

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Cheng, Xiaoyin, Zhoulei Li, Zhen Liu, et al. "Direct Parametric Image Reconstruction in Reduced Parameter Space for Rapid Multi-Tracer PET Imaging." IEEE Transactions on Medical Imaging 34, no. 7 (2015): 1498–512. http://dx.doi.org/10.1109/tmi.2015.2403300.

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Zinnhardt, Bastian, Hayet Pigeon, Benoit Thézé, et al. "Combined PET imaging of the inflammatory tumor microenvironment identifies margins of unique radiotracer uptake." Cancer Research 77, no. 8 (2017): 1831–41. https://doi.org/10.1158/0008-5472.CAN-16-2628.

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The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated inflammatory response is pivotal to support growth and invasion. Factors of glioma growth, inflammation, and invasion, such as the translocator protein (TSPO) and matrix metalloproteinases (MMP), may serve as specific imaging biomarkers of the glioma microenvironment. In this study, non-invasive imaging by positron emission tomography (PET) with [<sup>18</sup>F]DPA-714 (TSPO) and [<sup>18</sup>F]BR-351 (MMP) was used for assessment of localization and quantification of the expression of TSPO and MMP. Imaging

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Urso, Luca, Luca Filippi, Angelo Castello, et al. "PSMA PET/CT in Castration-Resistant Prostate Cancer: Myth or Reality?" Journal of Clinical Medicine 12, no. 22 (2023): 7130. http://dx.doi.org/10.3390/jcm12227130.

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Background: prostate-specific membrane antigen (PSMA) ligand PET has been recently incorporated into international guidelines for several different indications in prostate cancer (PCa) patients. However, there are still some open questions regarding the role of PSMA ligand PET in castration-resistant prostate cancer (CRPC). The aim of this work is to assess the clinical value of PSMA ligand PET/CT in patients with CRPC. Results: PSMA ligand PET has demonstrated higher detection rates in comparison to conventional imaging and allows for a significant reduction in the number of M0 CRPC patients.

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Chiotis, Konstantinos, Laure Saint-Aubert, Irina Savitcheva, et al. "Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm." Eur J Nucl Med Mol Imaging 43, no. 9 (2016): 1686–99. https://doi.org/10.1007/s00259-016-3363-z.

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PURPOSE: The aim of this study was to explore the cerebral distribution of the tau-specific PET tracer [(18)F]THK5317 (also known as (S)-[(18)F]THK5117) retention in different stages of Alzheimer's disease; and study any associations with markers of hypometabolism and amyloid-beta deposition. METHODS: Thirty-three individuals were enrolled, including nine patients with Alzheimer's disease dementia, thirteen with mild cognitive impairment (MCI), two with non-Alzheimer's disease dementia, and nine healthy controls (five young and four elderly). In a multi-tracer PET design [(18)

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Zhang, Jeff L., A. Michael Morey, and Dan J. Kadrmas. "Application of separable parameter space techniques to multi-tracer PET compartment modeling." Physics in Medicine and Biology 61, no. 3 (2016): 1238–58. http://dx.doi.org/10.1088/0031-9155/61/3/1238.

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Beyer, Leonie, Alexander Nitschmann, Henryk Barthel, et al. "Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury." European Journal of Nuclear Medicine and Molecular Imaging 47, no. 12 (2020): 2911–22. http://dx.doi.org/10.1007/s00259-020-04788-w.

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Abstract Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes

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Romanchek, Gregory, Greyson Shoop, and Shiva Abbaszadeh. "Application of Quantum Entanglement Induced Polarization for Dual-Positron and Prompt Gamma Imaging." Bio-Algorithms and Med-Systems 19, no. 1 (2023): 9–16. http://dx.doi.org/10.5604/01.3001.0054.1817.

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The intrinsic resolution of Positron Emission Tomography (PET) imaging is bound by positron range effects, wherein the radioactive decay of the imaging tracer occurs at a disjoint location from positron annihilation. Compounding this issue are the variable ranges positrons achieve, depending on tracer species (the energy they are emitted with) and the medium they travel in (bone vs soft tissue, for example) – causing the range to span more than an order of magnitude across various study scenarios (~0.19 mm to ~6.4 mm). Radioisotopes, such as Zr-89, exhibit dual emissions of positron and prompt

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Black, Noel F., Scott McJames, and Dan J. Kadrmas. "Rapid Multi-Tracer PET Tumor Imaging With $^{18}{\hbox {F-FDG}}$ and Secondary Shorter-Lived Tracers." IEEE Transactions on Nuclear Science 56, no. 5 (2009): 2750–58. http://dx.doi.org/10.1109/tns.2009.2026417.

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15

Pouliot, Frederic, Fred Saad, Patrick O. Richard, et al. "Prevalence of intra-patient inter-metastatic heterogeneity in mCRPC patients based on triple-tracer PET imaging: The 3TMPO study." Journal of Clinical Oncology 41, no. 16_suppl (2023): 5033. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.5033.

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5033 Background: Intra-patient inter-metastatic heterogeneity (IIH) has been demonstrated in metastatic castration resistant prostate cancer (mCRPC) patients based on genomic and imaging studies, most often after several lines of therapies. IIH is of utmost importance for PSMA radioligand therapy (RLT) eligibility, biopsy-based precision medicine and/or treatment intensification decision-making. The Triple-Tracer strategy against Metastatic PrOstate cancer (3TMPO) study (NCT04000776) is a prospective multicenter PET imaging study that was designed to determine the prevalence of IIH in mCRPC pa

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Sriprapa, Tossaporn, Thanete Doungta, Napamon Sritongkul, and Malulee Tantawiroon. "Development of the Purification Process of Gallium-68 Eluted from Germanium-68/Gallium-68 Generator." Siriraj Medical Journal 76, no. 2 (2024): 90–96. http://dx.doi.org/10.33192/smj.v76i2.266113.

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Objective: 68Ga has a half-life of 68 minutes, with 89% of its decay is through positron emission. It is available from generator systems and possesses suitable property for labeling radioligands. These aspects make 68Ga a promising tracer for positron emission tomography (PET) imaging. This study aims to develop the purification process of the 68Ga eluates from 68Ge/68Ga generator after its recommended shelf-life and ensuring the quality through the radiolabeling process. Materials and Methods: In this study, we explored the development of a purification method for 68Ga eluted from a68Ge/68Ga

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Ghaemi, M. "Differentiating multiple system atrophy from Parkinson's disease: contribution of striatal and midbrain MRI volumetry and multi-tracer PET imaging." Journal of Neurology, Neurosurgery & Psychiatry 73, no. 5 (2002): 517–23. http://dx.doi.org/10.1136/jnnp.73.5.517.

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Dorow, Donna S., Carleen Cullinane, Nelly Conus, et al. "Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033." European Journal of Nuclear Medicine and Molecular Imaging 33, no. 4 (2006): 441–52. http://dx.doi.org/10.1007/s00259-005-0039-5.

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Engel, Brian J., Vincenzo Paolillo, Md Nasir Uddin, et al. "Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging." Cancers 15, no. 15 (2023): 3787. http://dx.doi.org/10.3390/cancers15153787.

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The worldwide incidence of hepatocellular carcinoma (HCC) continues to rise, in part due to poor diet, limited exercise, and alcohol abuse. Numerous studies have suggested that the loss or mutation of PTEN plays a critical role in HCC tumorigenesis through the activation of the PI3K/Akt signaling axis. The homozygous knockout of PTEN in the livers of mice results in the accumulation of fat (steatosis), inflammation, fibrosis, and eventually progression to HCC. This phenotype bears a striking similarity to non-alcoholic steatohepatitis (NASH) which is thought to occupy an intermediate stage bet

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de Bie, Katelijne C. C., Hans Veerman, Yves J. L. Bodar, et al. "Higher Preoperative Maximum Standardised Uptake Values (SUVmax) Are Associated with Higher Biochemical Recurrence Rates after Robot-Assisted Radical Prostatectomy for [68Ga]Ga-PSMA-11 and [18F]DCFPyL Positron Emission Tomography/Computed Tomography." Diagnostics 13, no. 14 (2023): 2343. http://dx.doi.org/10.3390/diagnostics13142343.

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This study aimed to investigate the association between the 68Ga- or 18F-radiolabeled prostate-specific membrane antigen (PSMA) tracer expression, represented by the maximum standardised uptake value (SUVmax) of the dominant intraprostatic lesion, and biochemical recurrence (BCR) in primary prostate cancer (PCa) patients prior to robot-assisted radical prostatectomy (RARP). This was a retrospective, multi-centre cohort study of 446 patients who underwent [68Ga]Ga-PSMA-11 (n = 238) or [18F]DCFPyL (n = 206) Positron Emission Tomography/Computed Tomography (PET/CT) imaging prior to RARP. SUVmax w

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Colovic, Milena, Matthew Nodwell, Leo Escano, et al. "Preclinical In Vivo Imaging of Multiple Myeloma with [ 18f]Fluorohomoleucine (FHL) PET/CT." Blood 142, Supplement 1 (2023): 1935. http://dx.doi.org/10.1182/blood-2023-188363.

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Purpose: Imaging of patients with multiple myeloma (MM) remains challenging due to its multi-focal nature affecting bone marrow, bone structures and soft tissue. As a result, current diagnostic methods like X-rays, CT and MRI scans only provide a partial understanding of disease activity and treatment response, lacking a comprehensive overview. Although 2-deoxy-2-[ 18F]fluoro-D-glucose (FDG) positron emission tomography (PET) has become the standard for detecting multifocal cancer spread, its use in MM patients is limited due to metabolic heterogeneity of MM and limited sensitivity in detectin

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Shang, Qingyao, Rongxi Wang, Jialin Xiang, Zhaohui Zhu, and Xin Wang. "Abstract P2-07-14: Head-to-head comparison of the dual-targeting tracer [68Ga]Ga-RM26-RGD and [18F]FDG for PET imaging of breast cancer." Clinical Cancer Research 31, no. 12_Supplement (2025): P2–07–14—P2–07–14. https://doi.org/10.1158/1557-3265.sabcs24-p2-07-14.

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Abstract Purpose/Background: Radiolabeled RM26 and RGD peptide analogs have been investigated for imaging gastrin releasing peptide receptor (GRPR) and integrin αvβ3 receptor expression in multiple types of tumors. However, the diagnostic efficacy of the RM26-RGD heterodimer for primary lesions and axillary lymph node metastases in breast cancer patients has not been systematically evaluated. This multi-center prospective study provides the first head-to-head comparison of [68Ga]Ga-RM26-RGD with conventional [18F]FDG PET/CT in breast cancer patients. Materials and Methods: This prospective stu

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Fu, Jing, Alan Solomon, Patrick Carberry, et al. "Personalizing Amyloidosis Therapy with Real Time PET Imaging of Fibril-Reactive Monoclonal Antibody Cael-101." Blood 132, Supplement 1 (2018): 1003. http://dx.doi.org/10.1182/blood-2018-99-118177.

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Abstract Background AL amyloidosis is the most common type of systemic amyloidosis in western countries and has a poor prognosis, with a median survival of 12 to 18 months. Despite the improved prognosis gained by eliminating the offending plasma cell clone, mortality remains high due to multi-organ dysfunction caused by persistent, insoluble amyloid fibril deposits. The amyloid fibril-reactive murine monoclonal antibody 11-1F4 was designed to target amyloid deposits by directly binding to a conformational epitope present on human light-chain amyloid fibrils. The murine form of this antibody h

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Hami, Rihab, Sena Apeke, Pascal Redou, et al. "Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images." Journal of Imaging 9, no. 6 (2023): 124. http://dx.doi.org/10.3390/jimaging9060124.

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Despite the intensive use of radiotherapy in clinical practice, its effectiveness depends on several factors. Several studies showed that the tumour response to radiation differs from one patient to another. The non-uniform response of the tumour is mainly caused by multiple interactions between the tumour microenvironment and healthy cells. To understand these interactions, five major biologic concepts called the “5 Rs” have emerged. These concepts include reoxygenation, DNA damage repair, cell cycle redistribution, cellular radiosensitivity and cellular repopulation. In this study, we used a

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Tariq, A., M. Kwok, A. Pearce, et al. "The role of dual tracer PSMA and FDG PET/CT in Renal Cell Carcinoma (RCC) compared to conventional imaging: A multi-institutional case series with intra-individual comparison." European Urology Open Science 33 (November 2021): S176. http://dx.doi.org/10.1016/s2666-1683(21)02749-x.

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Tariq, Arsalan, Michael Kwok, Adam Pearce, et al. "The role of dual tracer PSMA and FDG PET/CT in renal cell carcinoma (RCC) compared to conventional imaging: A multi-institutional case series with intra-individual comparison." Urologic Oncology: Seminars and Original Investigations 40, no. 2 (2022): 66.e1–66.e9. http://dx.doi.org/10.1016/j.urolonc.2021.11.006.

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Zeng, Fuzhen, Jingwan Fang, Amanjule Muhashi, and Huafeng Liu. "Direct reconstruction for simultaneous dual-tracer PET imaging based on multi-task learning." EJNMMI Research 13, no. 1 (2023). http://dx.doi.org/10.1186/s13550-023-00955-w.

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Abstract Background Simultaneous dual-tracer positron emission tomography (PET) imaging can observe two molecular targets in a single scan, which is conducive to disease diagnosis and tracking. Since the signals emitted by different tracers are the same, it is crucial to separate each single tracer from the mixed signals. The current study proposed a novel deep learning-based method to reconstruct single-tracer activity distributions from the dual-tracer sinogram. Methods We proposed the Multi-task CNN, a three-dimensional convolutional neural network (CNN) based on a framework of multi-task l

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Pan, Bolin, Paul K. Marsden, and Andrew J. Reader. "Deep learned triple-tracer multiplexed PET myocardial image separation." Frontiers in Nuclear Medicine 4 (April 11, 2024). http://dx.doi.org/10.3389/fnume.2024.1379647.

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IntroductionIn multiplexed positron emission tomography (mPET) imaging, physiological and pathological information from different radiotracers can be observed simultaneously in a single dynamic PET scan. The separation of mPET signals within a single PET scan is challenging due to the fact that the PET scanner measures the sum of the PET signals of all the tracers. The conventional multi-tracer compartment modeling method (MTCM) requires staggered injections and assumes that the arterial input functions (AIFs) of each tracer are known.MethodsIn this work, we propose a deep learning-based metho

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Sun, Zhuxu, Xi Jiang, Guangbo Fu, Suan Sun, and Weijing Tao. "The Characteristics of Prostate Mucinous Adenocarcinoma Visualized by 68Ga-PSMA, 68Ga-FAPI, and 18F-FDG PET/CT." Clinical Nuclear Medicine, June 5, 2025. https://doi.org/10.1097/rlu.0000000000006004.

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Primary prostate mucinous adenocarcinoma is an exceedingly rare entity with distinct imaging characteristics. We report the case of a 62-year-old man with biopsy-proven prostate mucinous adenocarcinoma. The patient underwent MRI and multi-tracer PET/CT. PET/CT images demonstrated the prostate lesion with moderate uptake of 68Ga-PSMA and 68Ga-FAPI, yet significantly high 18F-FDG uptake. No abnormal radiotracers’ uptake was observed elsewhere in the body. Multi-tracer PET/CT findings suggest that 18F-FDG may be a more suitable radiotracer for the systemic assessment of primary prostate mucinous

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Fang, Jingwan, Fuzhen Zeng, and Huafeng Liu. "Signal separation of simultaneous dual-tracer PET imaging based on global spatial information and channel attention." EJNMMI Physics 11, no. 1 (2024). http://dx.doi.org/10.1186/s40658-024-00649-9.

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Abstract Background Simultaneous dual-tracer positron emission tomography (PET) imaging efficiently provides more complete information for disease diagnosis. The signal separation has long been a challenge of dual-tracer PET imaging. To predict the single-tracer images, we proposed a separation network based on global spatial information and channel attention, and connected it to FBP-Net to form the FBPnet-Sep model. Results Experiments using simulated dynamic PET data were conducted to: (1) compare the proposed FBPnet-Sep model to Sep-FBPnet model and currently existing Multi-task CNN, (2) ve

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Vraka, Chrysoula, Matej Murgaš, Lucas Rischka, et al. "Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-06906-0.

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AbstractSimultaneous characterization of pathologies by multi-tracer positron emission tomography (PET) is among the most promising applications in nuclear medicine. Aim of this work was the simultaneous production of two PET-tracers in one module and test the relevance for human application. [11C]harmine and [11C]DASB were concurrently synthesized in a ‘two-in-one-pot’ reaction in quality for application. Dual-tracer protocol was simulated using 16 single PET scans in different orders of tracer application separated by different time intervals. Volume of distribution was calculated for single

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Ellis, Sam, Andrew Mallia, Colm J. McGinnity, Gary J. R. Cook, and Andrew J. Reader. "Supporting data for 'Multi-Tracer Guided PET Image Reconstruction'." July 10, 2018. https://doi.org/10.5281/zenodo.1308883.

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This dataset contains the data used to produce the paper: '<em><strong>Multi-Tracer Guided PET Image Reconstruction</strong></em>' by Ellis <em>et al</em>, IEEE Transactions on Radiation and Plasma Medical Sciences (2018) DOI: https://doi.org/10.1109/TRPMS.2018.2856581. Please see the article for a full description of methodology used to obtain this data.  The dataset comprises a number of MATLAB data files (.mat) and MATLAB scripts (.m), corresponding to each figure in the article. Running the .m script in MATLAB for each figure will reproduce that figure approxima

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Velasco, Carlos, Adriana Mota-Cobián, Jesús Mateo, and Samuel España. "Development of a blood sample detector for multi-tracer positron emission tomography using gamma spectroscopy." EJNMMI Physics 6, no. 1 (2019). http://dx.doi.org/10.1186/s40658-019-0263-x.

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Abstract Background Multi-tracer positron emission tomography (PET) imaging can be accomplished by applying multi-tracer compartment modeling. Recently, a method has been proposed in which the arterial input functions (AIFs) of the multi-tracer PET scan are explicitly derived. For that purpose, a gamma spectroscopic analysis is performed on blood samples manually withdrawn from the patient when at least one of the co-injected tracers is based on a non-pure positron emitter. Alternatively, these blood samples required for the spectroscopic analysis may be obtained and analyzed on site by an aut

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Muller, Florence M., Elizabeth J. Li, Margaret E. Daube-Witherspoon, et al. "Impact of deep learning denoising on kinetic modelling for low-dose dynamic PET: application to single- and dual-tracer imaging protocols." European Journal of Nuclear Medicine and Molecular Imaging, March 12, 2025. https://doi.org/10.1007/s00259-025-07182-6.

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Abstract Purpose Long-axial field-of-view PET scanners capture multi-organ tracer distribution with high sensitivity, enabling lower dose dynamic protocols and dual-tracer imaging for comprehensive disease characterization. However, reducing dose may compromise data quality and time-activity curve (TAC) fitting, leading to higher bias in kinetic parameters. Parametric imaging poses further challenges due to noise amplification in voxel-based modelling. We explore the potential of deep learning denoising (DL-DN) to improve quantification for low-dose dynamic PET. Methods Using 16 [18F]FDG PET s

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Miao, Ying, Runhua Feng, Rui Guo, et al. "Utility of [68Ga]FAPI-04 and [18F]FDG dual-tracer PET/CT in the initial evaluation of gastric cancer." European Radiology, December 16, 2022. http://dx.doi.org/10.1007/s00330-022-09321-1.

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Abstract Objectives We aimed to investigate the role of [68Ga]FAPI-04 and [18F]FDG dual-tracer PET/CT for the initial assessment of gastric cancer and to explore the factors associated with their uptake. Methods This study enrolled 62 patients with histopathologically confirmed gastric cancer. We compared the diagnostic performance of [68Ga]FAPI-04, [18F]FDG, and combined dual-tracer PET/CT. The standardized uptake value (SUV) and tumor-to-background ratio (TBR) were also measured, and the factors that influence tracer uptake were analyzed. Results [68Ga]FAPI-04 PET/CT detected more primary le

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Pan, Bolin, Paul K. Marsden, and Andrew J. Reader. "Self-supervised parametric map estimation for multiplexed PET with a deep image prior." Physics in Medicine & Biology, January 7, 2025. https://doi.org/10.1088/1361-6560/ada717.

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Abstract Multiplexed positron emission tomography (mPET) imaging allows simultaneous observation of physiological and pathological information from multiple tracers in a single PET scan. Although supervised deep learning has demonstrated superior performance in mPET image separation compared to purely model-based methods, acquiring large amounts of paired single-tracer data and multi-tracer data for training poses a practical challenge and needs extended scan durations for patients. In addition, the generalisation ability of the supervised learning framework is a concern, as the patient being

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Griessinger, Jennifer, Julian Schwab, Qian Chen, et al. "Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis." npj Breast Cancer 8, no. 1 (2022). http://dx.doi.org/10.1038/s41523-022-00398-x.

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AbstractThe staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ. When both invasive ductal carcinoma and coincident ductal carcinoma in situ are present, assessment of the extent and localization of both components is required for optimal therapeutic planning. We have used a mouse model of breast cancer to evaluate the feasibility of applying molecular imaging to assess the local status of cancers in vivo. Multi-tracer positron emi

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Pan, Bolin, Paul K. Marsden, and Andrew J. Reader. "Kinetic model-informed deep learning for multiplexed PET image separation." EJNMMI Physics 11, no. 1 (2024). http://dx.doi.org/10.1186/s40658-024-00660-0.

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Abstract Background Multiplexed positron emission tomography (mPET) imaging can measure physiological and pathological information from different tracers simultaneously in a single scan. Separation of the multiplexed PET signals within a single PET scan is challenging due to the fact that each tracer gives rise to indistinguishable 511 keV photon pairs, and thus no unique energy information for differentiating the source of each photon pair. Methods Recently, many applications of deep learning for mPET image separation have been concentrated on pure data-driven methods, e.g., training a neural

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Nordberg, Agneta K., Konstantinos Chiotis, Igor C. Fontana, et al. "Diagnostic reactive astrogliosis biomarkers in Alzheimer´s disease continuum." Alzheimer's & Dementia 19, S17 (2023). http://dx.doi.org/10.1002/alz.078424.

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AbstractBackgroundThe Alzheimer’s disease (AD) biomarker field is moving rapidly. Creating a platform where multi‐PET tracer approaches and various fluid biomarkers with discriminative power in the early pathological stages could provide deeper insight into the role of reactive astrogliosis in the AD continuum. Accumulating data indicates that reactive astrogliosis may play a critical role in the early stages and, perhaps, precedes other pathological hallmarks of AD. Different PET tracers for imaging reactive astrogliosis are now available along with plasma GFAP showing a direct correlation wi

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Dehsarvi, Amir, Jannis Denecke, Davina Biel, et al. "ADPrep ‐ A fully automated Alzheimer’s Disease Neuroimaging Preprocessing Pipeline for MRI and multi‐tracer PET data." Alzheimer's & Dementia 19, S10 (2023). http://dx.doi.org/10.1002/alz.081918.

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AbstractBackgroundState‐of‐the‐art preprocessing of MRI and PET data is crucial for Alzheimer’s disease (AD) neuroimaging research. Therefore, standardization and harmonization of neuroimaging preprocessing across sites is key to generate comparable and sharable datasets and to reduce potential bias introduced by different preprocessing strategies. Further, neuroimaging preprocessing requires strong expertise in different programming languages (R/MATLAB/Python/Bash) and software packages (SPM/FSL/AFNI/FreeSurfer), i.e., a major barrier for non‐expert users. Therefore, we developed a docker‐bas

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Dehsarvi, Amir, Jannis Denecke, Davina Biel, et al. "ADPrep ‐ A fully automated Alzheimer’s Disease Neuroimaging Preprocessing Pipeline for MRI and multi‐tracer PET data." Alzheimer's & Dementia 19, S16 (2023). http://dx.doi.org/10.1002/alz.079614.

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AbstractBackgroundState‐of‐the‐art preprocessing of MRI and PET data is crucial for Alzheimer’s disease (AD) neuroimaging research. Therefore, standardization and harmonization of neuroimaging preprocessing across sites is key to generate comparable and sharable datasets and to reduce potential bias introduced by different preprocessing strategies. Further, neuroimaging preprocessing requires strong expertise in different programming languages (R/MATLAB/Python/Bash) and software packages (SPM/FSL/AFNI/FreeSurfer), i.e., a major barrier for non‐expert users. Therefore, we developed a docker‐bas

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"Identification of target tissue for glioma gene therapy by multi-tracer PET imaging." European Journal of Cancer 38 (November 2002): S145. http://dx.doi.org/10.1016/s0959-8049(02)81135-2.

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"1198. Identification of Target Tissue for Gene Therapy by Multi-Tracer PET-Imaging." Molecular Therapy 5, no. 5 (2002): S389. http://dx.doi.org/10.1016/s1525-0016(16)44028-1.

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Siebold, Kathrin, Lea Göbel, Paul Konken, Andreas Faust, and Ryan Gilmour. "Design and Synthesis of a Sialic Acid‐Derived Tracer for 18F‐PET Multiple Sclerosis Imaging." European Journal of Organic Chemistry, January 17, 2025. https://doi.org/10.1002/ejoc.202401381.

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Multiple Sclerosis (MS) is a leading cause of nontraumatic neurological disability in young adults, and efforts to understand disease progression continue to be intensively pursued. This is essential in order to reconcile the societal impact of this condition with the conspicuous absence of effective treatment regimes. Whilst magnetic resonance imaging (MRI) has revolutionized the field, enabling MS to be visualized in patients, distinguishing between other diseases that cause myelin sheath damage is a persistent challenge. Positron Emission Tomography (PET) holds great promise in differentiat

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Salimi, Yazdan, Zahra Mansouri, René Nkoulou, Ismini Mainta, and Habib Zaidi. "Deep Learning-Based CT-Less Cardiac Segmentation of PET Images: A Robust Methodology for Multi-Tracer Nuclear Cardiovascular Imaging." Journal of Imaging Informatics in Medicine, May 6, 2025. https://doi.org/10.1007/s10278-025-01528-0.

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Abstract Quantitative cardiovascular PET/CT imaging is useful in the diagnosis of multiple cardiac perfusion and motion pathologies. The common approach for cardiac segmentation consists in using co-registered CT images, exploiting publicly available deep learning (DL)-based segmentation models. However, the mismatch between structural CT images and PET uptake limits the usefulness of these approaches. Besides, the performance of DL models is not consistent over low-dose or ultra-low-dose CT images commonly used in clinical PET/CT imaging. In this work, we developed a DL-based methodology to t

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Harrison, Theresa M., Susan M. Landau, Suzanne L. Baker, Martin Boswell, and William J. Jagust. "The Berkeley PET Imaging Pipeline: Harmonization of Alzheimer’s disease PET biomarkers across studies." Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.095834.

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AbstractBackgroundCollection of neuroimaging data is resource‐intensive. Multi‐site studies have emerged as an effective way to amass large collections of PET scans, but data collected across many sites and scanners require specialized processing approaches. The Berkeley PET Imaging Pipeline (BPIP) and tools for numerical data post‐processing allow us to 1) process multi‐site and multi‐study PET scans using harmonized, largely automated tools and 2) disseminate numerical quantitative data.MethodPET data are harmonized by first using standard, tracer‐specific PET protocols and applying spatial

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Alberts, Ian, Hasan Sari, Clemens Mingels, et al. "Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients." Cancer Imaging 23, no. 1 (2023). http://dx.doi.org/10.1186/s40644-023-00540-3.

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AbstractRecently introduced long-axial field-of-view (LAFOV) PET/CT systems represent one of the most significant advancements in nuclear medicine since the advent of multi-modality PET/CT imaging. The higher sensitivity exhibited by such systems allow for reductions in applied activity and short duration scans. However, we consider this to be just one small part of the story: Instead, the ability to image the body in its entirety in a single FOV affords insights which standard FOV systems cannot provide. For example, we now have the ability to capture a wider dynamic range of a tracer by imag

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Velasco, Carlos, Adriana Mota-Cobián, Jesús Mateo, and Samuel España. "Explicit measurement of multi-tracer arterial input function for PET imaging using blood sampling spectroscopy." EJNMMI Physics 7, no. 1 (2020). http://dx.doi.org/10.1186/s40658-020-0277-4.

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Kang, Han Gyu, Hideaki Tashima, Hidekatsu Wakizaka, et al. "Development of an ultrasensitive small animal PET with 4-layer DOI detectors for sub-second dynamic rodent imaging." Physics in Medicine & Biology, June 4, 2025. https://doi.org/10.1088/1361-6560/ade112.

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Abstract Objective: Dynamic PET imaging is important for preclinical research since it can visualize the functional information of rodent models as a function of time. However, the temporal resolution of small animal PET imaging has been limited to a scale of seconds due to low sensitivity, and it is not sufficient to capture cardiac or brain function accurately. Here, we present an ultrasensitive small-animal PET scanner with total-body coverage for sub-second dynamic imaging of a rat.&#xD;Methods: The ultrasensitive small animal PET scanner has a 155 mm inner diameter and 325.6 mm axial

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Chouliaras, Leonidas, and John T. O’Brien. "The use of neuroimaging techniques in the early and differential diagnosis of dementia." Molecular Psychiatry, August 22, 2023. http://dx.doi.org/10.1038/s41380-023-02215-8.

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AbstractDementia is a leading cause of disability and death worldwide. At present there is no disease modifying treatment for any of the most common types of dementia such as Alzheimer’s disease (AD), Vascular dementia, Lewy Body Dementia (LBD) and Frontotemporal dementia (FTD). Early and accurate diagnosis of dementia subtype is critical to improving clinical care and developing better treatments. Structural and molecular imaging has contributed to a better understanding of the pathophysiology of neurodegenerative dementias and is increasingly being adopted into clinical practice for early an

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