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Relevant bibliographies by topics / Multi unit particulates (MUPS)

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Journal articles

Academic literature on the topic 'Multi unit particulates (MUPS)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Multi unit particulates (MUPS)"

1

Dr, . M. Sunitha Reddy* Raju Eddagiri S. Muhammad Fazal Hl Haq Dr. V. Venkateswarlu. "DESIGN AND IN-VITRO CHARACTERIZATION OF DELAYED RELEASE MULTI UNIT PARTICULATES USING WURSTER TECHNOLOGY." Indo American Journal of Pharmaceutical Sciences 04, no. 12 (2017): 4315–24. https://doi.org/10.5281/zenodo.1098072.

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The aim of the present research was to design and characterize delayed release Multi Unit Particles (MUPS). These were produced primarily for the purpose of oral modified release dosage forms having gastro resistant and delayed-release properties. During the development of MUPS agglomeration, generations of fines and twins formation are identified as critical issues. The delayed release multiple units were prepared by layering drug suspension using Wurster technology. The prepared multi unit particulates consist of successive layers of drug layer (Esomeprazole), barrier coat and enteric coat (

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2

Parihar, Akshay, Bhupendra Gopalbhai Prajapati, Kiran Patel, and Himanshu Paliwal. "Formulation, evaluation, and optimization of the omeprazole magnesium multi-unit particulate controlled release tablets using different concentrations of polymers." IP International Journal of Comprehensive and Advanced Pharmacology 7, no. 4 (2023): 211–17. http://dx.doi.org/10.18231/j.ijcaap.2022.040.

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Multi-Unit Particulates (MUPs) with matrix pellets are used to develop controlled release products of various active pharmaceutical ingredients. They may allow improvement in solubility and thereby bioavailability of poorly soluble drugs. Omeprazole magnesium is a derivative of benzimidazole which belongs to the group of proton pump inhibitors that exhibits degradation in gastric acid with short biological life and variability in bioavailability. The drug degradation problem was overcome by the coating of pellets with enteric coating agents which disperse in the gastrointestinal tract more hom

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3

Agrawal, Surendra, Ketaki Joshi, and Ram Gaud. "Formulation development of multi unit particulate system (MUPS) for anti-diabetic drugs." Asian Journal of Pharmaceutical Sciences 11, no. 1 (2016): 77–78. http://dx.doi.org/10.1016/j.ajps.2015.10.060.

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4

Čierna, Martina, Pavel Mučaji, Miroslava Špaglová, Mária Čuchorová, and Oliver Macho. "Chitosan and Sodium Alginate Implementation as Pharmaceutical Excipients in Multiple-Unit Particulate Systems." Polymers 14, no. 14 (2022): 2822. http://dx.doi.org/10.3390/polym14142822.

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This study aimed to prepare and evaluate pellets containing acyclovir as a model drug. Pellets were prepared by the extrusion–spheronization process. Aqueous solutions of natural marine polymers (sodium alginate, chitosan) were compared to semi-synthetic hydroxypropyl methylcellulose (HPMC) in the role of binders. The study focused on the characterization of the pellet properties that are crucial for the formulation of the final dosage form, such as in multi-unit pellet system (MUPS) tablets or hard gelatin capsules filled with the pellets. Finally, the mentioned dosage forms were tested for d

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5

Khobragade, Deepak S., K. Vighneshwar, and Mrunali S. Potbhare. "Development and Evaluation of Novel Multi-unit Pellet System Formulation of Metoprolol Succinate for Extended Release." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1219–27. http://dx.doi.org/10.25258/ijddt.12.3.49.

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Metaprolol succinate is a highly water-soluble drug with extensive first-pass metabolism. It needs to be administered about 3-4 times a day for optimum therapeutic effect. Conventional extended-release formulations are available but have their own disadvantages. The study was to designed formulate and evaluate the prolonged-release compressed multiple-unit pellet system of Metoprolol succinate. MUPS are novel formulations with benefits of both single and multi unit dosage forms and can provide extended drug delivery release profile and increase the efficiency profile of the drug. Metaprolol su

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6

Tushar, Tonge* Shilpa Borkar Jagdish Baheti. "A Review on Multiple Unit Pellet System (MUPS) Delivery Systems." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4474–90. https://doi.org/10.5281/zenodo.15533086.

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The pharmaceutical industry is currently concentrating on creating novel drug delivery systems that improve therapeutic efficacy and lessen adverse effects. When a medication product needs to be administered in a modified release pattern to senior patients, the oral drug delivery system becomes problematic, particularly because they have trouble swallowing. The design of solid dosage forms has made extensive use of Multiple Unit Pellet Systems (MUPS) tablets in recent years. One of the more recent and difficult technologies that combines the benefits of tablets with pellet-filled capsules in a

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7

Wanda B. Putri, Friesca S. Nurhaidah, Helmy Yusuf, and Maria L.A.D. Lestari. "Pengaruh Desain Punch Terhadap Mutu Fisik dan Disolusi Tablet MUPS Metformin HCl." MEDICINUS 36, no. 3 (2023): 36–47. http://dx.doi.org/10.56951/af7svb90.

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The compaction of multi-unit pellet system (MUPS) into tablets is a potential alternative for sustained release drugs. Tableting tools (punch and die) affect the compaction process and quality of MUPS tablets. The punch design intends to preserve the desired drug release of compacted pellets. This study aims to investigate the effect of two punch shapes, the flat face radius edge (FFRE) and concave-faced punch (concave), each at two different cup depths, on the physical properties and release profile of metformin HCl MUPS tablets. Drug release parameters, t50 values, showed that the metformin

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8

Drechsler, Salome, Peter S. H. Leeflang, Tammo H. A. Bijmolt, and Martin Natter. "Multi-unit price promotions and their impact on purchase decisions and sales." European Journal of Marketing 51, no. 5/6 (2017): 1049–74. http://dx.doi.org/10.1108/ejm-12-2013-0729.

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Purpose The purpose of this paper is to compare the impact of different multi-unit promotions (MUPs) and a single-unit promotion (SUP) on store-level sales and consumer-level purchase probability and quantity decision. Design/methodology/approach The paper combines two empirical studies. Study 1 applies a hierarchical multiplicative model to store-level sales data for four product categories provided by a large Dutch retail chain. Study 2 presents a laboratory experiment in which the quantity requirements of the two focal MUP frames are manipulated to assess their impact on consumer purchase d

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9

Guo, Su Juan, Guo Zheng Kang, and Cheng Dong. "Numerical Simulations for Uniaxial Ratcheting of SiC_P/6061Al Composites Concerning Particulate Arrangement." Advanced Materials Research 26-28 (October 2007): 317–20. http://dx.doi.org/10.4028/www.scientific.net/amr.26-28.317.

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Based on three dimensional cubic unit cell models containing several particulates with certain particulate arrangements, the monotonic tensile and uniaxial ratcheting behaviors of particulate reinforced metal matrix composites (i.e., T6-treated SiCP/6061Al composites) were numerically simulated by using elastic-plastic finite element code ABAQUS with help of newly developed user material subroutine (UMAT). In the simulations, the effects of different particulate arrangements inside the unit cell models on the monotonic tensile and ratcheting behaviors of the composites were discussed. It is sh

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10

Thio, Daniel Robin, Paul Wan Sia Heng, and Lai Wah Chan. "MUPS Tableting—Comparison between Crospovidone and Microcrystalline Cellulose Core Pellets." Pharmaceutics 14, no. 12 (2022): 2812. http://dx.doi.org/10.3390/pharmaceutics14122812.

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Multi-unit pellet system (MUPS) tablets were fabricated by compacting drug-loaded pellets of either crospovidone or microcrystalline cellulose core. These pellets were produced by extrusion-spheronization and coated with ethylcellulose (EC) for a sustained drug release function. Coat damage due to the MUPS tableting process could undermine the sustained release function of the EC-coated pellets. Deformability of the pellet core is a factor that can impact the extent of pellet coat damage. Thus, this study was designed to evaluate the relative performance of drug-loaded pellets prepared with ei

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